LOCUS       NZ_CP095376            25512 bp    DNA     circular CON 06-NOV-2024
DEFINITION  Amycolatopsis sp. FBCC-B4732 chromosome, complete genome.
ACCESSION   NZ_CP095376
VERSION     NZ_CP095376.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FBCC-B4732
  ORGANISM  Amycolatopsis sp. FBCC-B4732
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10190959)
  AUTHORS   Choi,A.
  TITLE     Complete Genome Sequence of Amycolatopsis pretoriensis strain
            FBCC-B4732
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10190959)
  AUTHORS   Choi,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-APR-2022) Bioresources Collection & Research Team,
            Nakdonggang National Institute of Biological Resources, Donam 2-gil,
            Sangju-si, Gyeongsangbuk-do 37242, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 75.1x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_023008405.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 10:39:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,364
            CDSs (total)                      :: 9,298
            Genes (coding)                    :: 9,177
            CDSs (with protein)               :: 9,177
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 121
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 50 of 121
            Pseudo Genes (incomplete)         :: 81 of 121
            Pseudo Genes (internal stop)      :: 14 of 121
            Pseudo Genes (multiple problems)  :: 19 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:14:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4191104
            Orig. end                         :: 4216616
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP095376.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from NNIBR.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25512
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="25"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..25512
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25512
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15512](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15512)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(22..36)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.79"
                     /tool="antismash"
     misc_feature    781..792
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.1"
                     /tool="antismash"
     gene            complement(1145..2572)
                     /locus_tag="MUY14_RS18300"
                     /old_locus_tag="MUY14_18300"
     CDS             complement(1145..2572)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225277.1"
                     /locus_tag="MUY14_RS18300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18300"
                     /product="APC family permease"
                     /protein_id="WP_247024215.1"
                     /transl_table=11
                     /translation="MSSPTRSGAPQPALERKIGPLQATAINMTQMCGIGPFVTIPAMVA
                     TMGGPQAMFGWIIGAIVALADGLIWAELGAAMPGAGGTYLYLREAFQYRTGRLMPFLFV
                     WSAVLFIPLIMSTGIIGLVQYLGYLIPGVTDDAGTTPLGKIIGVGITLVIVAALFRKIG
                     QIGKLTTVLFVVMLIAVLTTVVAAFTHFSGAQAFAFTPGAFSSAGTGTFWGGLGAGLII
                     AIYDYLGYNTSAYLGGEVRDPGRTLPRSILFSIVGIMSLYFLLQVGVLGSVPLEELKTA
                     TSVASTVLEQAWGTVTAKIVTVFIVVAAIGSVFAGLLGGSRVPFEAARDKVFLSMFGKL
                     HPKLNLPTAGVLTMGAITIIGSLFTLTDVINAAVSTLVIIQSLAQVAAIWTLRRRQPEL
                     KRPYRQWLYPLPTLLALVGWVYIYVSATPLSIGLSLGWIALGALAYLVYAKTENTWPFG
                     PKEIKEAFAADPEGAQA"
     misc_feature    complement(2599..2613)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.41"
                     /tool="antismash"
     misc_feature    2603..2616
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.01"
                     /tool="antismash"
     gene            2711..3883
                     /locus_tag="MUY14_RS18305"
                     /old_locus_tag="MUY14_18305"
     CDS             2711..3883
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466961.1"
                     /locus_tag="MUY14_RS18305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18305"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_247025165.1"
                     /transl_table=11
                     /translation="MRALNQRLVLDRLRGQGEATRPQIAADTGLSKPTVGQALLDLEQH
                     GLVRTTGRSLAGPGRAAVVYQAAPDAGHVVGVDIGRRAIRIAVADLEGSIVARLDEPNR
                     CRSASALVRTVSESVERAVAAAGLRPHEVVATVVGTPGVPDPATGTVHRAPNLPGWERR
                     GLLHELVAALAVAGSDVVVENDANLCAVGEHALGAALGVDVLVCLTVGTGIGMGLLVDG
                     KLFRGAHGAAGEIADLPYGPLPAGAAARRPGPVETAAAGQAVVDAARALGLTKARTAKD
                     VFRLARSGDARALRVVEEEAEKLAYVVSAVTAVLDPRLIVLGGGIGGNADLLAEPMRRA
                     LAATIPVVPEIAAGQLGEDAVLAGAIATALGTARELVFDRRGLHRTASGA"
     gene            complement(3888..6842)
                     /locus_tag="MUY14_RS18310"
                     /old_locus_tag="MUY14_18310"
     CDS             complement(3888..6842)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017539.5"
                     /locus_tag="MUY14_RS18310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18310"
                     /product="NACHT domain-containing NTPase"
                     /protein_id="WP_247024216.1"
                     /transl_table=11
                     /translation="MVDPVTAKLAGVAAETILKRIRRMAARRGYVKDSAVAVTERKLEN
                     QYEGYWPASLMRLLPPGRTQRDIDRFVRTPELQAFTRLLIAAHMLDGRPELRKRLFGSI
                     QDALLDFLPPVFVADREVPSEPEQRIARYQAALRKYGAEFCEHLSASCDAAAEDIKQRS
                     EDPAVAHAWAYNLVATDILQAVEGSLAHLARDVRERTSLDWVPRYREQFVAYHREINSP
                     DVNDRKTIDYEDLFVGPTVLQSDPKTLRPFDDIGAQRPETTFRRFWETLDQAVLLGDPG
                     AGKSTSSTVAAIELCRHAGVVPFVVVLREVPDPGFYLPELLVRVLRKYEVAVTPDSLEK
                     LLREGSSLVVFDGLDEIADASRRADLAKKIETVACAYPFLKILVTCRKVGYRTAALSDR
                     RFSVFQVGPFSRGQTREYVTKWFTTQAGLSGRYVEYSVHDFLAASKEMQDLTQNPLLLA
                     FMCVLYRGLRTLPTDRPSLYDKCVQLLLGDRDKGIIDNVPSIEDTKTALSRIASVELEG
                     GDQVGLTRSQIVEDLVPFLVSTVFATERGAERFVRDMLAWCRGRAWMFTDFGPGDDHRD
                     LFTFTHASFREYFGALYFVRTHPDVESVVAHLYPLVRDGKSEIYAQVCCALFEQGRLSG
                     ASSVISAIVERLKADYPVLLDRDLRAIGTGQDRAHVDRVRSVGSAYLAGMADGLPLSPE
                     ATRSLVRLALEQTALGDSASVARLLDPAYRHHESILELMVEDLIASVGALRGEAFARRQ
                     VWFAIHARYLLAGAAQGVPIRRKAVESLNGVVKAIGPYLKRYDGVLDIEYAMFVQSGNT
                     ESENFVKLDGSQFCQVFAFLFEQYTVPIPGVGPSSTIRWVFDSFRSEHREAMPVARVAA
                     FLRSFGAAVDAHLDRLYELSPPQHAAIADFGFEAVLARIAAYPVECRSSLLFLIAAQME
                     LNERLDPVSTYSEDRGVVEGWARQVGVGERVAVLLEQWARGVIDLWSPFDQGTS"
     misc_feature    complement(4689..4691)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6916..7146)
                     /locus_tag="MUY14_RS18315"
                     /old_locus_tag="MUY14_18315"
     CDS             complement(6916..7146)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020646884.1"
                     /locus_tag="MUY14_RS18315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18315"
                     /product="hypothetical protein"
                     /protein_id="WP_247024217.1"
                     /transl_table=11
                     /translation="MTAEELMIEFALTRLDHPDLDLEDIAALVVRRGGPERELEFASRN
                     LADRGELRGTAFRTAVEYVLRVVLTLRGPSA"
     misc_feature    complement(7246..7266)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.03"
                     /tool="antismash"
     gene            7257..8744
                     /locus_tag="MUY14_RS18320"
                     /old_locus_tag="MUY14_18320"
     CDS             7257..8744
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015100938.1"
                     /locus_tag="MUY14_RS18320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18320"
                     /product="MFS transporter"
                     /protein_id="WP_247024218.1"
                     /transl_table=11
                     /translation="MTTTRAPIRQTLSPRRRWAALGVLVGAVLLLAIDGTVLYLAVPSL
                     TRELAPTATEILWIGDIYSLALAGLLVTAGNLADRFGRKKVLLLGTAAFGLASVLAAFS
                     PTAGVLVLARLLLGVAGATIMPSTLSLIRTLFTDPRERTRAVAIWSAGSGGGIALGPLV
                     GGTLLEHYWWGSVFLINVPVVVVFLIAGAFLLPESRDPNPGRFDLLSAALSMVAIVPLV
                     YAVKHAVSEGLDAQAAVAAVLGVAAGVLFLRRQRRAADPLIDVGLFRNGAFSGAVLANF
                     ISVFALMGLLFFFSQYLQLVRGFSPLRAGLAEMPATLASIVVVGAVGVVVRRLGQGRAV
                     AAGLAVAALGLTLVAVAEQAPQYWWLGLTLVPVGLGVGLALTLTVDSVLSAVPRDKAGS
                     ASAISETAYELGAALGIALLGSLVTVVYRAFLPTGAPGEVRESLASAVSALDPASDLAQ
                     AARDAFTGAMQVTSLAAAAVTAVAALIAWRTIPSGKD"
     gene            8747..9304
                     /locus_tag="MUY14_RS18325"
                     /old_locus_tag="MUY14_18325"
     CDS             8747..9304
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225273.1"
                     /locus_tag="MUY14_RS18325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18325"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_247024219.1"
                     /transl_table=11
                     /translation="MPRKAGRSPEETRRALLDAAATAIRTRGISASLDDIARVAGVSKG
                     GLLYHFPAKDALVRTLAQDILDTFRTEVHAALDPADTAPGRLVRAYVRASLDTSQDEVA
                     IRENIALIAQLISIPEIAGLARADAERWDRELHDDGLPADVVTLVVAAADGASTAPLWG
                     VGIDVAAARRLERQLLDLTRGT"
     misc_feature    complement(9330..9346)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.1"
                     /tool="antismash"
     misc_feature    9391..9407
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            9453..10007
                     /locus_tag="MUY14_RS18330"
                     /old_locus_tag="MUY14_18330"
     CDS             9453..10007
                     /EC_number="3.4.24.-"
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225272.1"
                     /locus_tag="MUY14_RS18330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18330"
                     /product="snapalysin family zinc-dependent metalloprotease"
                     /protein_id="WP_247024220.1"
                     /transl_table=11
                     /translation="MSRKFALVGAAALALTMTPLAAGTASAATDQEAAVTTVYYSTASA
                     PSFRSVINAGAANWNNSVTNVRLVERNSGASLRYTEGNDPRGSYASTNGHGSGTIFIDY
                     TQARQYNPTRIAAHETGHALGLPDHYSGPCSELMSGGGPGPSCTNAVPNSAERSRVNSL
                     WANGLVATNAQERVYETVYGY"
     gene            complement(10001..11221)
                     /gene="mftD"
                     /locus_tag="MUY14_RS18335"
                     /old_locus_tag="MUY14_18335"
     CDS             complement(10001..11221)
                     /EC_number="1.4.3.26"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR03966"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156396.1"
                     /locus_tag="MUY14_RS18335"
                     /note="MftD, an enzyme found in the mycofactocin
                     biosynthesis locus, performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases; Derived
                     by automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="MUY14_18335"
                     /product="pre-mycofactocin synthase MftD"
                     /protein_id="WP_247024221.1"
                     /sec_met_domain="TIGR03966 (E-value: 1.5e-210, bitscore:
                     697.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTWFESVAEAQRRAKKRLPASVYSALIAGSEKGLTLADNLGAFD
                     ELRFAPRTAGHHGQRDLATHVLGRDVALPVLISPTGVQAVHPDGEVAVARAAAARGTSI
                     GLSSFGSKPIEEVVAANPNTYFQVYWTGTRDDIERRLDRARAAGAVGIILTLDWSFSHS
                     RDWGSPHIPERLTPRELLRFAPEGIARPRWLLDYVKTRRLPDLSVPNMASPGEEAPTFF
                     GAYGQWMQTPPPSWEDVAWLRAQWDGPFLLKGVIRVDEARRAVDAGVSALSVSNHGGNN
                     LDGTPATIRALPSIADAVGSEVEVLLDGGIRRGSDVVKALALGAKAVLIGRAYLWGLAA
                     GGQAGVENVLDVLRNGIDSTVLALGKKSVHELTREDVLVPAGFAAELGAAHEGGPDRSP
                     GHLQRTQ"
     gene            complement(11218..12627)
                     /gene="mftF"
                     /locus_tag="MUY14_RS18340"
                     /old_locus_tag="MUY14_18340"
     CDS             complement(11218..12627)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076812.1"
                     /locus_tag="MUY14_RS18340"
                     /note="Members of this protein family, MftF, are
                     glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969).; Members of this protein family, MftF,
                     are glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969).; Members of this protein family, MftF,
                     are glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969); Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18340"
                     /product="mycofactocin biosynthesis glycosyltransferase
                     MftF"
                     /protein_id="WP_247024222.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.5e-19,
                     bitscore: 68.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPLPPGFRIALDRDTKQLTADLLFGGSPARVLRLTAAGQAALRE
                     LADGPVSSAATGALARHLTDAGLAHPLPPEPDRAADVTVVVPVLGRPGPLARCLAGLGD
                     RHPVLIVDDGSEDPAAIAGVAAAHGAGLVRRDVNGGPGAARNTALDHVPTELVAFVDSD
                     CVPAPGWVEPLAAHFADPLVAAVAPRVCPLAADTAAGRYTRAASSLDLGDRPARVAPGT
                     RTSYVPTAALVVRRSALVEAGAFDPALRVGEDVDLVWRLHAAGYRVRYAPDVTVGHHEP
                     ETWRALLGRRARYGTSAAPLAKRHPGALAPLGVHPWPALTVGALLAGRPLLAAGGFAGA
                     VGGMVGTLRAHDVPPDGVVRAMATAVHQTWLGCGRYGTQFAAPLLAALLVPRGWGRRAA
                     VASLLLGPPLTAWAKTRPGLDPVRYTAAAIADDVAYGGGVWAGCLAHRTLEPVRPALVR
                     RPLRFTTKGTR"
     gene            complement(12624..13409)
                     /locus_tag="MUY14_RS18345"
                     /old_locus_tag="MUY14_18345"
     CDS             complement(12624..13409)
                     /NRPS_PKS="Domain: PKS_KR (4-178). E-value: 3.1e-14. Score:
                     45.2. Matches aSDomain:
                     nrpspksdomains_MUY14_RS18345_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658593.1"
                     /locus_tag="MUY14_RS18345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18345"
                     /product="mycofactocin-coupled SDR family oxidoreductase"
                     /protein_id="WP_247024223.1"
                     /transl_table=11
                     /translation="MTRRTALVTGAARGIGAATVLRLAQQGYAVLAVDVAADEPALPYP
                     MGTEADLAAVVEKAGEHAAAFVADVRDPAAMAAAVREAERRWGGLDVAIAAAGVIAGGV
                     PLWEVPEDQERAVLEVDLHGVVHLARAAVPALLRRPKPRSGRFLAVASAAATRGLPMLA
                     AYCAAKAGVAGLVRALGAELGETGVTANAVSPGSTDTPILAESARLYALPDAAAFAAQQ
                     PVHRLLDAGEVAAVLAFLAGPDSGAVTGAVVPVDGGLAL"
     aSDomain        complement(12876..13397)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MUY14_RS18345_PKS_KR.1"
                     /evalue="3.10E-14"
                     /label="MUY14_RS18345_PKS_KR.1"
                     /locus_tag="MUY14_RS18345"
                     /protein_end="178"
                     /protein_start="4"
                     /score="45.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TALVTGAARGIGAATVLRLAQQGYAVLAVDVAADEPALPYPMGTE
                     ADLAAVVEKAGEHAAAFVADVRDPAAMAAAVREAERRWGGLDVAIAAAGVIAGGVPLWE
                     VPEDQERAVLEVDLHGVVHLARAAVPALLRRPKPRSGRFLAVASAAATRGLPMLAAYCA
                     AKAGVAGLVRA"
     CDS_motif       complement(13329..13391)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MUY14_RS18345_0001"
                     /evalue="3.00E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="MUY14_RS18345"
                     /protein_end="27"
                     /protein_start="6"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LVTGAARGIGAATVLRLAQQG"
     gene            complement(13406..14089)
                     /gene="mftE"
                     /locus_tag="MUY14_RS18350"
                     /old_locus_tag="MUY14_18350"
     CDS             complement(13406..14089)
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076817.1"
                     /locus_tag="MUY14_RS18350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18350"
                     /product="mycofactocin biosynthesis peptidyl-dipeptidase
                     MftE"
                     /protein_id="WP_247024224.1"
                     /transl_table=11
                     /translation="MVRLADLSSPGVAARAAAGAILAVPIGATEQHGPHLPLTTDTDIA
                     LALCDGLAAARPEVLVAPAVPYGSSGEHAGFAGTLSIGQGATELLLLELGRSAAETFGR
                     LLFVSAHGGNTGPVTRAAARLRAESRDVSVFRPRWPGEPHAGRAETALQLTMRPGSVRM
                     ERAVVGDRRPIGELLPLLREGGVRAVTATGVLGDPTGATAVEGKELLAGLTAALVSHVD
                     EWRRV"
     gene            complement(14089..15231)
                     /gene="mftC"
                     /locus_tag="MUY14_RS18355"
                     /old_locus_tag="MUY14_18355"
     CDS             complement(14089..15231)
                     /EC_number="1.3.98.7"
                     /EC_number="4.1.99.26"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983863.1"
                     /locus_tag="MUY14_RS18355"
                     /note="MftC is a radical SAM/SPASM enzyme that catalyzes
                     the first two steps in biosynthesis of the electron carrier
                     mycofactocin from the terminal Val-Tyr dipeptide of the
                     precursor peptide MftA.; MftC is a radical SAM/SPASM enzyme
                     that catalyzes the first two steps in biosynthesis of the
                     electron carrier mycofactocin from the terminal Val-Tyr
                     dipeptide of the precursor peptide MftA; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="MUY14_18355"
                     /product="mycofactocin radical SAM maturase"
                     /protein_id="WP_247024225.1"
                     /sec_met_domain="PF04055 (E-value: 6.8e-24, bitscore: 84.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1e-06, bitscore: 27.4,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-13, bitscore:
                     50.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLVDEFQYGLDAPICLTWELTYACNLSCVHCLSSSGRRDPRELS
                     TVECKALIDEFERMQIFYVNIGGGEPTVRPDFWELVDYATGHHVGVKFSTNGVKITPEV
                     ARRLAGSDYVDVQISLDGATAEVNDHVRGPGSYATAIRAMEHLADAGFENFKISVVMTR
                     HNIAQLDAFKAIADRYRAQLRITRLRPSGRGADTWDELHPTAAQQRELYDWLVAHGENV
                     LTGDSFFHLAGYGGGGLPGLNLCGAGRVVCLVDPVGDVYACPFAIHDTFLAGNTRSEGG
                     FTRVWRESELFTELRSPQSAGACTSCSAFDACRGGCMAAKFFTGLPLDGPDPECVRGHG
                     ELALAGVTSVPKPSLDHSHRRRPVPVTIGMRRPCDENPLA"
     gene            complement(15231..15512)
                     /gene="mftB"
                     /locus_tag="MUY14_RS18360"
                     /old_locus_tag="MUY14_18360"
     CDS             complement(15231..15512)
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Mycofactocin_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076821.1"
                     /locus_tag="MUY14_RS18360"
                     /note="MftB, a small protein, is a peptide chaperone that
                     assists the radical SAM enzyme MftC in performing two
                     modifications to the C-terminal Val-Tyr dipeptide of the
                     mycofactocin precursor peptide, MftA. MftB's role is
                     analogous to the role of PqqD in the biosynthesis of PQQ, a
                     cofactor that derives entirely from a Tyr and a Glu in the
                     precursor PqqA.; MftB, a small protein, is a peptide
                     chaperone that assists the radical SAM enzyme MftC in
                     performing two modifications to the C-terminal Val-Tyr
                     dipeptide of the mycofactocin precursor peptide, MftA.
                     MftB's role is analogous to the role of PqqD in the
                     biosynthesis of PQQ, a cofactor that derives entirely from
                     a Tyr and a Glu in the precursor PqqA.; MftB, a small
                     protein, is a peptide chaperone that assists the radical
                     SAM enzyme MftC in performing two modifications to the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     peptide, MftA. MftB's role is analogous to the role of PqqD
                     in the biosynthesis of PQQ, a cofactor that derives
                     entirely from a Tyr and a Glu in the precursor PqqA;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18360"
                     /product="mycofactocin biosynthesis chaperone MftB"
                     /protein_id="WP_247024226.1"
                     /sec_met_domain="Mycofactocin_RRE (E-value: 2.3e-28,
                     bitscore: 97.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTEPFDLDAAWRLDSRVAIRPERFGALLYHFGTRRLSFLKSPAL
                     LDVVRSLDAHPSARAACAGAGVAAPELPRYRAALAALAESRMIQPRSL"
     aSDomain        complement(15249..15488)
                     /aSDomain="Mycofactocin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a mycofactocin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MUY14_RS18360_Mycofactocin_RRE.1"
                     /evalue="6.90E-31"
                     /identifier="RREFam016.1"
                     /label="MUY14_RS18360"
                     /locus_tag="MUY14_RS18360"
                     /protein_end="88"
                     /protein_start="8"
                     /score="97.3"
                     /tool="antismash"
                     /translation="DAAWRLDSRVAIRPERFGALLYHFGTRRLSFLKSPALLDVVRSLD
                     AHPSARAACAGAGVAAPELPRYRAALAALAESRMI"
     gene            complement(15502..15603)
                     /gene="mftA"
                     /locus_tag="MUY14_RS18365"
                     /old_locus_tag="MUY14_18365"
     CDS             complement(15502..15603)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947188.1"
                     /locus_tag="MUY14_RS18365"
                     /note="Mycofactocin is a small molecule electron carrier
                     derived from the final two amino acids, Val-Tyr, of MftA,
                     the mycofactocin precursor. It plays a role in redox
                     homeostasis and the metabolism of alcohols and aldehydes in
                     Actinobacteria, including Mycobacterium tuberculosis;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18365"
                     /product="mycofactocin precursor MftA"
                     /protein_id="WP_125307730.1"
                     /transl_table=11
                     /translation="MTEKIAEEPVEETPVAEDLLVEEVSIDGMCGVY"
     misc_feature    15632..15652
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.3"
                     /tool="antismash"
     gene            15713..16333
                     /gene="mftR"
                     /locus_tag="MUY14_RS18370"
                     /old_locus_tag="MUY14_18370"
     CDS             15713..16333
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0036042 - long-chain fatty acyl-CoA
                     binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="mftR"
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082061.1"
                     /locus_tag="MUY14_RS18370"
                     /note="MftR, the mycofactocin system transcriptional
                     regulator, is an uncharacterized TetR family DNA-binding
                     transcription factor. Its role is inferred by context. It
                     occurs as part of the biosynthesis locus for mycofactocin,
                     a partially characterized electron carrier derived from the
                     terminal Val-Tyr dipeptide of the precursor peptide MftA,
                     through a radical SAM enzyme-mediated process.; MftR, the
                     mycofactocin system transcriptional regulator, is an
                     uncharacterized TetR family DNA-binding transcription
                     factor. Its role is inferred by context. It occurs as part
                     of the biosynthesis locus for mycofactocin, a partially
                     characterized electron carrier derived from the terminal
                     Val-Tyr dipeptide of the precursor peptide MftA, through a
                     radical SAM enzyme-mediated process; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="MUY14_18370"
                     /product="mycofactocin system transcriptional regulator"
                     /protein_id="WP_247024227.1"
                     /transl_table=11
                     /translation="MTQRTPAARRGRPPGTSARELEVIALRLFTERGFHETTVDEIAAT
                     AGVSRRTFFRYYDAKSDVLWNEFDAEVAAITEHLAAADGTLPVLDAVREAVIAANHYRA
                     EDVTELRMRMHLLSSVPELAASATRHYDAWERAVSAYVGARTGQPADALYPLAVGRAVL
                     ATCRAAYERWSARADADLTVYLDAALRALATGFADPSPIEPGN"
     gene            16678..16836
                     /locus_tag="MUY14_RS18375"
                     /old_locus_tag="MUY14_18375"
     CDS             16678..16836
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MUY14_RS18375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MUY14_18375"
                     /product="hypothetical protein"
                     /protein_id="WP_247024228.1"
                     /transl_table=11
                     /translation="MSTDAAARERETPSGRGEPIIGQSPKRKVGNSVYVSVPGRVPVIK
                     AKRAKKD"
     gene            complement(16846..18531)
                     /locus_tag="MUY14_RS18380"
                     /old_locus_tag="MUY14_18380"
     CDS             complement(16846..18531)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024685.5"
                     /locus_tag="MUY14_RS18380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18380"
                     /product="SIR2 family protein"
                     /protein_id="WP_247024229.1"
                     /transl_table=11
                     /translation="MAEGSPSRMLDPDLFDRGDIFCFDAQPYLGELFETVRARKKPLTV
                     VVGAGVSMNSSLPSWRDLIDKMTNEIKNASTKKIALRDDSDLMRKAEIVLQILKDGGQD
                     VEDHTIIRRALYSDSHATPGVLADSIARLVCANRKYAGKRARLLTTNFDEILEAALRAY
                     FEEEDVESFSLKPGGSSAWKAWDRRLGRIGVMHLHGLVRQDGDPEEPIVLTESQFLKHG
                     AQVRDVISNALEGACTIFIGLGMSDPNLIGPLYATAEARPPRFSLVVPPGVNGVTTTEA
                     ARYAISSARYLEDKLGLRPIFLKSYSQLNQVISDLALAVVEPRRYRPTVKSDASLVYRR
                     RLTRALDDCYTGVGCGKGAEIPTGQAAEELTTRLHLALEIDDGPLQVLRELARQYGHPL
                     GGGAGENFGLFLWLRSRELEDERHRYILNLVGTSVYAHREDWSLRHHVKISRETEFAAA
                     QAVFTGNVQATNLTPTPIAQIWRGIFATPILLAGIGSDQMIGEDPADVLTVGAITLNST
                     FVIRTNGERVADEDLSLISKLDSAAKNLLLDSLDKAAQYAIHPN"
     misc_feature    complement(18567..18587)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.46"
                     /tool="antismash"
     misc_feature    complement(18603..18619)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.38"
                     /tool="antismash"
     gene            complement(18633..20015)
                     /locus_tag="MUY14_RS18385"
                     /old_locus_tag="MUY14_18385"
     CDS             complement(18633..20015)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007034931.1"
                     /locus_tag="MUY14_RS18385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18385"
                     /product="APC family permease"
                     /protein_id="WP_247024230.1"
                     /transl_table=11
                     /translation="MTTPALRRGLRTLGTLLITLSAISPASSVFIIAPGVLAGAGTGAF
                     FSFAAAAVVGVFMAFVYAELASAFPVAGGEYAIVARTLGRLPGFAVLGLMIITQVLIVA
                     VIALGVGTYLGVLFPGLPGPAAAAVTCVLAAVVGVFDIKLNAWVTGVFLAIEILALVVV
                     SALGLLHPARPLTDLVAHPVAAGGGPATIGAIAIAMSVAMFAYNGYGSAVYFGEETQDA
                     PRGIARAILLALAITVVAELVPVTAVLLGAPDLGALFGSENMLSTFITARGGSTLDTVL
                     SLAVALAIMNAVLAIVLISSRLVFSSGRDRAWPGAVNRALAAVHPRFGTPWVATVGTGI
                     VAAALCFVDPQLLLVVTSTSIVAVYAALCLGAIVGRRTGVTAHAQYRMPWFPVAPVLAL
                     AVLAFVVYQNVVDPAVGRPSLIVTAGIVLLAVGYYVLVLRRRGGWQLAEPVEHTSDSRT
                     NS"
     misc_feature    20101..20110
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.63"
                     /tool="antismash"
     misc_feature    20103..20117
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.23"
                     /tool="antismash"
     gene            20135..20737
                     /locus_tag="MUY14_RS18390"
                     /old_locus_tag="MUY14_18390"
     CDS             20135..20737
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159096.1"
                     /locus_tag="MUY14_RS18390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18390"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_247024231.1"
                     /transl_table=11
                     /translation="MARPSRAPERRAELIAVARRAVVERGILNLRLRDIADGAGLSSGS
                     VLYYFPTLTDLLREVQQEAVERFCTQREDAARGGTPRERLLATIRSGLPTGPSDELCVL
                     LYELGTIARRDPAYAARHVALFERQVRIYTGILEAGAATGEFTLTAEPVAIARNLVALE
                     DGYGLHLTQAVPTVDRATAEAMLLSFARTACSLEDLS"
     gene            20734..21801
                     /locus_tag="MUY14_RS18395"
                     /old_locus_tag="MUY14_18395"
     CDS             20734..21801
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159097.1"
                     /locus_tag="MUY14_RS18395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18395"
                     /product="P1 family peptidase"
                     /protein_id="WP_247024232.1"
                     /transl_table=11
                     /translation="MTRARDLGITLPGRPGTHNALTDVAGVEVGYTTVLEGDSVRTGVT
                     AVLPRGRADFAVPCAAGTFSLNGNGEMTGTAWLAETGSLALPVLITNTHAVGPCHRGVI
                     DWVVRERPDVAAEWLLPVVAETWDGYLNDINAPTIHSGYAGAALDAARGGALDEGSVGG
                     GTGMTCYGFKGGTGTASRLVPYGSDEYTVGVLVQANFGSRRELTVAGDHVGPRLAADDP
                     MAHWAPAPPGAGSVIVVVGTDAPLLPGQCTALARRVPLGLARTGTTGSHFSGDLFLAFS
                     TANPGALTSAFPRTAEAEYEQLRFVPWGRIDPFFEAVVQAVEEAVLNALVANREMTGHR
                     GHRAPAFPADFSRRN"
     gene            complement(21847..23718)
                     /locus_tag="MUY14_RS18400"
                     /old_locus_tag="MUY14_18400"
     CDS             complement(21847..23718)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225263.1"
                     /locus_tag="MUY14_RS18400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18400"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_247024233.1"
                     /transl_table=11
                     /translation="MKLRVLLSVLLAFAGVVPGAGVAAAAEAPVPAPAMGWASWNTFAA
                     KIDYATIKAQADALVSTGLKDAGYTYVNIDEGWWQGTRDGSGNITVDTAEWPGGMKAIA
                     DYLHGKGLKAGIYTDAGRDGCGYYYPTGRPAAPGSGSEGHYLQDMLQFQRWGFDFVKVD
                     WCGGDAEGLDPASTYRAISDANTAATAQTGRTLTLSICDWGKKNPWNWGAGTAPMWRTS
                     TDIIYYGQTATLPQALTNFDQAQHPVSQHTGYVNDPDMLTVGMPGLSAAQGRTEFGMWA
                     VSGAPLLAGNNLATMSTETANVLKNREVIAVDQDPRGLQGVKVAEDAAGLQVYGKVLAG
                     SGKRAVLLLNRTSSAATMTARWADLGLTAATAKVRNLWSASDQGSYANGYSVSVPADDS
                     VLLTVQGTDAAATHGTTITAAATGSAVATFTYNATTTRTATLAVNGQQPTVVAFPATGG
                     AARTVSAVVSLGKGTNNLTFSGTPPQLTDVAVLPLPGTNGVQVAGTQSGRCLDIDDNSI
                     TNGVQAQLWDCAGGPNQTWVPARGQLVVNGTKCLDAYDNGTANGTAVVSWDCNGRRNQQ
                     WTLNANGTITNAVSGLCLDASGAATGNGTKIILWACGGGANQQWTRR"
     gene            complement(23836..24315)
                     /locus_tag="MUY14_RS18405"
                     /old_locus_tag="MUY14_18405"
     CDS             complement(23836..24315)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MUY14_RS18405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MUY14_18405"
                     /product="hypothetical protein"
                     /protein_id="WP_247024234.1"
                     /transl_table=11
                     /translation="MRYVRVTRTGGADVVNFLDPEPYLRELPGLALPVGARAFAADSDH
                     YDFTGSRCVKDLRVGQLAVREAGFAKLAAELTFLPNRFKHFSGLVVRYDGVTNIDLDAN
                     RSGPGTRVWPASPSLGDLQLDEILPTAGGCSHEIAFTGGTLLVECADLEAEWLSE"
     gene            24532..24684
                     /locus_tag="MUY14_RS18410"
                     /old_locus_tag="MUY14_18410"
     CDS             24532..24684
                     /GO_component="GO:0032993 - protein-DNA complex [Evidence
                     IEA]"
                     /GO_process="GO:0006276 - plasmid maintenance [Evidence
                     IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225262.1"
                     /locus_tag="MUY14_RS18410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18410"
                     /product="CopG family transcriptional regulator"
                     /protein_id="WP_247024235.1"
                     /transl_table=11
                     /translation="MGDDDVKQFNVYLPIGLIRQLKHRAVETEQSLSALVAEALRAYLG
                     TEEEH"
     gene            24687..25031
                     /locus_tag="MUY14_RS18415"
                     /old_locus_tag="MUY14_18415"
     CDS             24687..25031
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225261.1"
                     /locus_tag="MUY14_RS18415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MUY14_18415"
                     /product="glyoxalase/bleomycin resistance/extradiol
                     dioxygenase family protein"
                     /protein_id="WP_247024236.1"
                     /transl_table=11
                     /translation="MTTEGIDAVYLETHNWGKAAKFFQALGYEIDFATDHNSGLLRNGD
                     GPHLFIAEVPGSQEPRQQVVFKVPDADAFRADDIVEVITPFEDTHYGTREMTVRDPDGR
                     TWTLSAPAAG"
ORIGIN
        1 tccggcgcga agccgccgcc gcggaacacg aagtccctgc cgttgatcgt gaactgccgc
       61 gcgccctccg gcagggccgc ggacttcccg accaggcgcg aggtcaccgt gcggataccg
      121 aaggtgctct tcgacgacgt cgagagcgtg ccgtcctgcg agaccgcggt gctcagcgtg
      181 tacagcggct ggtcgcccat cgagtacggc caccagacgc gcgggtgcgc gatcttcacc
      241 ggcgcgaacg ccacggtccg cttggtgttc gcggggatcg tcacgcgctg cttgacgacg
      301 accggcgcgc ccgagggcgg ggtgatcgtc gcggcgacgt cgccggtctg cggcgcggcc
      361 gcgtcgttgg tgacgtcgac cttcaccgtc agcttcgagc tcgacaggtc ggcggcgttg
      421 tcctgcacga cgtgggcgtt gtcgccggtg agcgcgtcgg acacctgcag ggtcggcggg
      481 aactggatgc cggtgttgtt gtccggcggg atctggcccc agtcgacctg gtcgagggtg
      541 tacatcttca gcgggtcgtt cgggtagacc ttgatcgcca gggtgttctt gcccggcttg
      601 accagcttcg tgacgtcgaa ggtgtgcccg gcgaacgcgc cgctgacgat gtccttcgtg
      661 gcgacgagct tgccgttcac ccagacgtcg ccttcgccga cgatgcccgg gatggtcagc
      721 ttcgcgtgct ggccggcctt gaagccggga gcgaagtcgg tccggtacca ccacgggtcg
      781 gagaacggtt tcgtgacgac ggggccgagc ttgtccacgt acccgaagca cttgcgcatg
      841 ttgtccgagt agaagacgtt cgggcacttg ccgttctgga cgagggcggt gatctcggtg
      901 ccgggcgcgc cggcgtcgtc cggcttcacc ggcagccagc cacgggtggc gtaccccggc
      961 gtggagacct tttccccgcc gtccttgacg ttcgcggtgg tcagcacctg ccagccctgc
     1021 gtgccgatgg tggtgagccc gtgcggcttg gcgaacgcct gcgtgtcttg agcggcggcc
     1081 gggccggcga ccgcgagcac gccggggacg agcaccagtg cggccaccgc cgcgagtttc
     1141 cgggtcatgc ctgggcccct tccgggtcgg cggcgaaagc ttccttgatc tccttgggac
     1201 cgaacggcca cgtgttctcc gtcttggcgt agacgaggta cgcgagcgcg ccgagggcga
     1261 tccagcccag cgacagcccg atggacagcg gcgtcgcgga aacgtagatg tagacccagc
     1321 cgaccagcgc gagcagcgtc ggcagcgggt agagccactg ccggtagggc cgcttcagct
     1381 ccggctggcg gcggcgcagc gtccagatgg ccgcgacctg ggccagcgac tggatgatga
     1441 ccagggtgga gacggcggcg ttgatgacgt cggtcagcgt gaacagcgag ccgatgatcg
     1501 tgatggcgcc catggtgagc acgcccgcgg tcggcaggtt cagcttgggg tgcagcttgc
     1561 cgaacatgga caggaacacc ttgtcccgcg cggcttcgaa cggcacgcgc gagccgccga
     1621 gcaggccggc gaacaccgag ccgatggccg cgacgacgat gaagacggtg acgatcttcg
     1681 ccgtcacggt gccccacgcc tgctccagca cggtcgaggc gaccgaggtg gcggtcttca
     1741 gctcttccag cggaaccgag ccgaggacgc cgacctgcag caggaagtac aggctcatga
     1801 tgcccacgat ggagaagagg atcgaccgcg ggagcgtccg tcccgggtcg cggacctcgc
     1861 cgccgaggta ggcgctggtg ttgtagccga ggtagtcgta gatcgcgatg atcaggccgg
     1921 cgccgaggcc gccccagaac gtgcccgtgc cggccgaact gaacgcgccc ggggtgaagg
     1981 cgaacgcctg cgcgccgctg aagtgcgtga acgcggcgac gacggtggtg agcaccgcga
     2041 tcagcatgac cacgaacagc accgtcgtga gcttgccgat ctggccgatc ttgcggaaca
     2101 gcgcggcgac gatgacgagc gtgatgccga cgccgatgat cttgcccagc ggcgtggtgc
     2161 ccgcgtcgtc ggtgacgccg gggatcaggt agccgaggta ctggacgagc ccgatgatgc
     2221 cggtggacat gatcagcggg atgaacagca ccgcgctcca cacgaacagg aacggcatca
     2281 gccgtccggt gcggtactgg aacgcttcgc gcaggtacag gtaggtgccg ccggcgcccg
     2341 gcatggcggc gccgagttcg gcccagatga gcccgtcggc cagcgcgacg atcgccccga
     2401 tgatccagcc gaacatcgcc tgcggcccgc ccatggtggc gaccatggcg gggatcgtga
     2461 cgaacgggcc gataccgcac atctgcgtca tgttgatcgc ggtcgcctgc agcgggccga
     2521 tcttgcgctc aagggccggt tgcggcgccc ctgaacgagt gggtgaactc acgacgtgcc
     2581 tccggctagt agttagtaaa gtttcttaac atagaacggg cggagtcgaa agagttccgt
     2641 ggataaactt gcggcaacac aggaggattc agtggggcaa aacgggccgc aggtgggaac
     2701 cccggcgaac atgcgggcgc tgaaccagcg cctggtcctg gaccggcttc gcggccaggg
     2761 cgaggcgacg cgaccgcaga tcgcggcgga cacgggactt tcgaaaccca cggtcggaca
     2821 ggcgctgctc gacctcgagc agcacggact ggtccggacc actgggcgca gcctggccgg
     2881 gccggggcgc gcggcggtcg tctaccaggc cgcgccggac gccgggcacg tcgtcggcgt
     2941 cgacatcggg cggcgcgcga tccggatcgc cgtcgccgac ctcgaaggca gcatcgtcgc
     3001 ccggctcgac gagcccaacc ggtgccgctc ggcgagcgcg ctggtgcgca cggtgagcga
     3061 atccgtcgaa cgcgcggtgg ccgcggccgg gctgcggccg cacgaggtcg tggcgacggt
     3121 cgtcggcacc cccggcgtcc ccgacccggc gaccggcacg gtgcaccgcg cacccaacct
     3181 gcccggctgg gagcggcgcg ggctgctgca cgaactcgtc gcggcgctgg ccgtcgccgg
     3241 ctcggacgtc gtggtggaga acgacgcgaa cctgtgcgcg gtcggcgagc acgccctcgg
     3301 cgcggcgctc ggcgtcgacg tgctggtgtg cctgacggtc ggcaccggca tcggcatggg
     3361 cctgctggtc gacggcaagc tgttccgcgg cgcgcacggc gcggcgggcg agatcgcgga
     3421 cctgccctac ggcccgctgc ccgccggcgc ggccgcccgc cgccccggcc cggtcgaaac
     3481 ggcggccgcg ggccaggcgg tggtcgacgc ggcccgcgcg ctgggcttga cgaaggcacg
     3541 cacggcgaag gacgtgttcc ggctggcccg gtcaggcgac gcgcgggcgc tgcgcgtggt
     3601 cgaggaagaa gccgagaagc tggcgtacgt ggtctcggcg gtgacggccg tcctggaccc
     3661 ccgcctgatc gtgctgggcg gcggcatcgg cggcaacgcg gacctgctgg ccgagccgat
     3721 gcggcgcgcg ctggcggcga cgatccccgt cgtcccggag atcgcggccg gccagctggg
     3781 cgaggacgcg gtgctggcgg gcgcgatcgc gacggcgctg ggcacggccc gcgagctggt
     3841 cttcgaccgc cgcggcctgc accgcacggc cagcggcgcc tgaccggtca gctggttccc
     3901 tgatcgaacg ggctccacag gtcgatcacg ccgcgcgccc actgctccag cagcaccgcg
     3961 acccgctcgc cgaccccgac ctgcctcgcc cagccctcga ccacgccgcg atcctcgctg
     4021 taggtggaca cggggtccag tcgttcgttg agttccatct gcgcggcgat caggaagagc
     4081 aggctggatc ggcactcgac cgggtaggcg gcgatccggg ccagcacggc ctcgaagccg
     4141 aagtccgcga tcgcggcgtg ttgagggggc gacagctcgt acaaccggtc gaggtgcgcg
     4201 tcgacggcgg caccgaagct ccggaggaag gccgcgaccc gggcgacggg catcgcctcg
     4261 cggtgttcgc tgcggaagga gtcgaacacc caccgaatgg tggaactcgg cccgacgccg
     4321 ggaatcggaa cggtgtactg ctcgaagagg aacgcgaaga cctggcagaa ctggcttcca
     4381 tccagcttga cgaagttctc cgactcggtg ttcccgctct gaacgaacat cgcgtactcg
     4441 atgtccagca cgccgtcgta ccgcttcagg tagggaccga tcgccttgac gaccccgttg
     4501 agtgattcga cggccttgcg ccggatcggt actccttgcg cggcgccggc cagcaggtag
     4561 cgcgcgtgga tggcgaacca gacctggcga cgggcaaacg cttcgccccg cagggcgccg
     4621 acactggcga tgaggtcttc gaccatcagt tcgaggatcg actcgtgatg ccggtaggcg
     4681 ggatccagta acctggcgac cgaagcgctg tcaccgagcg ccgtctgctc gagggccagc
     4741 cgaaccagcg aacgggtcgc ctccgggctg agcgggaggc catcggccat ccccgcgagg
     4801 tacgcggacc cgacggaccg cacgcggtcc acgtgggcgc ggtcctgccc ggttccgatg
     4861 gcccgcaggt cccggtcgag cagcaccggg tagtcggcct tcaaccgctc cacgatggcc
     4921 gagatcaccg atgaggcgcc ggaaagccgc ccctgctcga acagcgcgca gcagacctgc
     4981 gcgtagattt cggatttgcc gtccctgacc agcgggtaga ggtgggccac cacgctctcg
     5041 acatcgggat gggttcgtac gaagtagagc gctccgaagt actcccggaa gctcgcatgg
     5101 gtgaaggtga acaggtcacg gtggtcgtcg ccgggaccga aatccgtgaa catccacgcc
     5161 cggccgcggc accaggccag catgtcgcgc acaaaccttt ccgccccccg ctcggtggcg
     5221 aacaccgtcg agacgaggaa gggaaccagg tcctcgacga tctgcgaccg ggttagcccg
     5281 acctggtccc cgccctccag ttcgacggag gcgatacggg acaacgccgt cttcgtgtcc
     5341 tcgatgctcg gaacattgtc gatgattccc ttgtcccggt cgccgaggag cagctgcacg
     5401 cacttgtcgt acaacgacgg gcgatccgtc ggaagcgtgc gcaagccccg gtagagcacg
     5461 cacatgaacg cgagcaggag ggggttctgg gtgaggtctt gcatttcctt gctggcggcg
     5521 aggaagtcgt ggaccgaata ctcgacgtac cgaccgctca gcccggcctg ggtggtgaac
     5581 cacttggtca cgtactcccg ggtctgccct cgcgagaagg gaccgacctg gaagacgctg
     5641 aaccgccggt cgctgagcgc cgccgtccgg taccccacct tccggcaggt gaccaggatc
     5701 ttgaggaacg ggtacgcaca tgcgaccgtt tcgatcttct tcgccaggtc cgcccgccgg
     5761 ctggcgtccg ctatctcgtc caggccgtcg aagacgacca gggaacttcc ttctcgaagc
     5821 agcttctcca gagagtccgg tgtcaccgcg acttcgtact ttcgcaacac gcggacgagc
     5881 agctcaggta ggtagaagcc ggggtccggc acctcgcgga gcacgacgac gaacggcacc
     5941 acaccggcgt ggcggcacag ttcgatggca gccacggtgc tggacgtcga cttcccggct
     6001 cccgggtcgc cgagcagcac ggcttggtcg agggtttccc aaaaccggcg aaaggtggtt
     6061 tccggccgct gagcaccgat gtcgtcaaag ggtcgcaggg tcttcgggtc gctctgcagc
     6121 acggtcgggc cgacgaacag gtcctcgtag tcgatcgtct tccggtcgtt gacgtcgggg
     6181 gagttgatct cgcggtggta ggcgacgaac tgctcccggt accgcggaac ccagtccagg
     6241 ctcgtccgct cgcggacgtc acgggcgagg tgggccagcg agccttcgac ggcttggagg
     6301 atgtcggtgg cgaccaggtt gtacgcccag gcgtgagcca ccgcaggatc ttccgaacgt
     6361 tgcttgatgt cctccgccgc ggcatcgcag ctggcactga ggtgctcaca gaactccgcg
     6421 ccgtacttgc gcaaggccgc ttggtagcgg gcgatccgct gttcgggttc cgaggggact
     6481 tcccgatccg cgacgaagac cggcgggagg aagtcgagca gggcgtcctg aatcgacccg
     6541 aacaagcgct tccggagttc cgggcgaccg tccagcatgt gcgcggcgat cagcaaccgc
     6601 gtaaacgcct ggagctccgg agtccggaca aagcggtcga tgtcccgctg ggtgcgcccg
     6661 ggcggcagca accgcatgag cgaagccggc cagtaccctt cgtactggtt ctcgagcttc
     6721 cgctccgtga ccgcgacggc ggagtccttc acgtagccac gacgagccgc catccggcgg
     6781 atccgcttga ggatcgtctc cgcggcgacg ccggccagct tggccgtgac cggatcgacc
     6841 acttgcactc tcctgccccc gaagccagct gttcctggaa cagtcgcggc gccggaggcg
     6901 gttattacag gtgaactagg ccgagggtcc gcgcagggtc agcaccaccc gcaggacgta
     6961 ctcgaccgcc gtccggaagg ccgtgccgcg cagttcgccg cggtcggcca ggttgcggga
     7021 ggcgaactcc agctctcgct cggggccgcc ccggcggacg accagtgccg cgatgtcctc
     7081 gaggtcgagg tccgggtggt cgagccgggt cagcgcgaac tcgatcatca gctcttcggc
     7141 cgtcatcccg ctcctcccga ctcctccagc gtagccacaa ccgccgggcc gggaccggca
     7201 ttccgtggcc gagctcaccc gcgttactgt accgtccaga cggtatagta gtcggcatga
     7261 ccacgacccg cgccccgatc cggcagaccc tcagcccccg tcgccggtgg gccgcgctgg
     7321 gcgtgctcgt cggcgcggtg ctcctgctcg cgatcgacgg caccgtgctg tacctcgccg
     7381 tgccgtccct gacccgcgag ctcgcgccga ccgccaccga aatcctgtgg atcggcgaca
     7441 tctactcgct cgcgctggcc ggcctgctcg tcacggcggg caacctcgcc gaccgcttcg
     7501 gccgcaagaa ggtgctgctc ctcggcacgg ccgcgttcgg cctcgcctcc gtgctggccg
     7561 ccttctcccc caccgccggc gtgctcgtcc tcgcgcggct gctgctcggc gtcgcgggcg
     7621 cgacgatcat gccctcgaca ctctcgctga tccgcacgct gttcaccgac ccgcgtgagc
     7681 gcacccgcgc cgtcgcgatc tggtcggccg ggtccggcgg cggcatcgcg ctcggcccgc
     7741 tcgtcggcgg caccctgctg gagcactact ggtggggttc ggtgttcctg atcaacgtgc
     7801 cggtcgtcgt ggtcttcctg atcgcgggcg cgttcctgct gccggagtcg cgggacccga
     7861 acccgggccg cttcgacctg ctctcggcgg ccctctcgat ggtggcgatc gtgccgctgg
     7921 tgtacgcggt caagcacgcc gtcagcgagg gcctcgacgc ccaggcggcc gtggccgctg
     7981 tgctcggcgt cgccgccggc gtgctgttcc tccgccgtca gcggcgggcg gccgacccgc
     8041 tgatcgacgt cgggttgttc cgcaacggcg ccttcagcgg cgcggtgctc gcgaacttca
     8101 tctcggtctt cgcgttgatg ggactgctgt tcttcttctc gcagtacctg cagctggttc
     8161 gcggcttctc gccgctgcgg gccgggctcg ccgagatgcc cgcgacgctg gcctcgatcg
     8221 tcgtcgtggg cgccgtcggc gtggtcgtcc ggcggctcgg gcagggccgg gcggtcgccg
     8281 cgggcctggc cgtcgccgcg ctcgggctga ccctggtcgc ggtcgccgag caggcgccgc
     8341 agtactggtg gctgggcctg acgctggtac cggtcgggct cggcgtcggc ctggcgctga
     8401 cgctgaccgt cgactcggtg ctgtccgccg tcccgcggga caaggcgggc tcggcgtcgg
     8461 cgatctccga aacagcctac gaactcggtg cggcgctggg catcgcgctc ctcggctcgc
     8521 tggtcaccgt ggtgtaccgc gctttcctgc ccaccggggc gcccggcgag gtccgggagt
     8581 ccctcgcctc ggcggtgtcc gcgctcgacc cggcgtcgga cctcgcccag gcggcccggg
     8641 acgccttcac cggcgccatg caggtcacgt cgctggcggc ggccgccgtc accgccgtcg
     8701 cggcgctgat cgcctggcgt acgattccgt ccggaaagga ctgagcatgc ctcgcaaagc
     8761 cgggcgcagc ccggaggaaa cgcgccgggc gctgctcgac gcggccgcga ccgccatccg
     8821 cacgcgcggg atctcggcgt ccctcgacga catcgcgcgg gtggccgggg tgtcgaaagg
     8881 cgggctgctg taccacttcc cggcgaagga cgcgctggtg cgcacgctcg cccaggacat
     8941 cctcgacacc ttccgcaccg aggtccacgc ggcgctcgac ccggccgaca ccgccccggg
     9001 ccggctcgtg cgcgcctacg tccgggcgtc gctggacacg tcgcaggacg aggtcgcgat
     9061 ccgggagaac atcgcgctga tcgcccagct gatctcgatc ccggagatcg ccgggctggc
     9121 ccgcgcggac gccgagcggt gggaccgcga gctgcacgac gacggcctgc cggcggacgt
     9181 ggtcacgctg gtggtcgcgg cggccgacgg ggcgagcacg gcaccgctgt ggggcgtcgg
     9241 catcgacgtc gcggcggcgc ggaggctgga gcggcagctg ctcgacctga cccggggcac
     9301 ctgaccaggg tcgtgtcaac ccgtcgaagg tgttggtaaa tcaccacttc ccggccccta
     9361 cgttagtcgg ctccggcgaa cgtgtcttcc gggtaaattt tcgacagcgc gcgcaattcc
     9421 ggcaaatccc cgtccccacg aggagttctc cgatgtcgag gaagttcgcc ctggtcggcg
     9481 cagccgcact cgccctgacc atgaccccgc tcgccgcggg gaccgcgtcg gccgccacgg
     9541 accaggaagc cgcggtcacg acggtgtact acagcaccgc cagcgcaccg tcgttccgct
     9601 cggtgatcaa cgccggtgcc gccaactgga acaacagcgt gaccaacgtc agactggtcg
     9661 agcgcaactc cggcgccagc ctgcgctaca ccgagggcaa cgacccgcgt gggtcctacg
     9721 cctcgaccaa cggtcacggc agcggcacca tcttcatcga ctacacccag gcccggcagt
     9781 acaacccgac ccgcattgcg gcgcacgaga ccggtcacgc cctcgggctg ccggaccact
     9841 actcgggccc gtgctcggag ctgatgtcgg gtggcggccc cggcccgtcc tgcaccaacg
     9901 cggtgccgaa ctcggccgag cgcagccgcg tgaactcgct gtgggccaac ggcctcgtgg
     9961 cgacgaacgc gcaggagcgc gtctacgaaa ccgtgtacgg ctactgagtt cgctgaaggt
    10021 ggcccgggct ccggtccggg ccaccttcgt gcgcggcccc gagttcggcc gcgaagcccg
    10081 ccggcaccag cacgtcctcc cgggtgagtt cgtggacgct cttcttgccc agcgccagca
    10141 ccgtcgaatc gatcccgttg cgcagcacgt cgaggacgtt ttccaccccg gcctgccctc
    10201 ctgcggccag gccccacagg tacgcgcggc cgatcaggac cgccttggcg cccagcgcca
    10261 gcgctttcac gacgtcgctg ccgcggcgga tcccgccgtc cagcaggact tccacctccg
    10321 agccgaccgc gtccgcgatc gagggcaggg cgcggatcgt agccggggtg ccgtcgaggt
    10381 tgttgccgcc gtggttggac accgacagtg cgctgacgcc ggcgtcgacc gcgcggcggg
    10441 cctcgtcgac ccggatcaca cccttgagca ggaatggccc atcccactgc gcacgcagcc
    10501 aggccacgtc ctcccacgac ggcggcggcg tctgcatcca ctggccgtac gcgccgaaga
    10561 acgtcggtgc ttcttcgccc ggcgacgcca tgttcggcac gctcaagtcg ggcagccgcc
    10621 gcgttttgac gtagtccagc agccagcgcg ggcgggcgat gccttccggg gcgaaccgca
    10681 gcagctcgcg cggggtcagc cgctcgggga tgtgcgggct gccccagtcg cggctgtgcg
    10741 agaacgacca gtcgagcgtc aggatgatgc cgacggcccc cgcggcgcgg gcccggtcca
    10801 gccgccgctc gatgtcgtcg cgggtgcccg tccagtagac ctggaagtac gtgttcgggt
    10861 tcgcggcgac cacctcctcg atcggcttgc tgccgaagga ggacagcccg atcgacgtcc
    10921 cgcgcgcggc ggccgccctg gccaccgcga cctcgccgtc ggggtgcacg gcctgcaccc
    10981 cggtcgggga gatcagcacc gggagggcga cgtcgcggcc gagcacgtgc gtggccagat
    11041 cgcgctgccc gtggtggccg gccgtgcgcg gcgcgaaccg cagttcgtcg aacgcgccga
    11101 ggttgtcggc cagcgtgagg cccttctccg agcccgcgat gagggcggag tagaccgaag
    11161 cgggcagccg tttcttcgcg cgccgctggg cctccgcgac ggattcgaac caggtggtca
    11221 tcgggttccc ttcgtggtga agcgcagcgg gcgccggacg agcgccgggc ggaccggctc
    11281 gagcgtgcgg tgggccaggc agccggccca gacgccgccg ccgtacgcga cgtcgtcggc
    11341 gatcgccgcc gcggtgtagc ggacgggatc gagtccgggc cgggtcttgg cccacgcggt
    11401 cagcggcggg ccgagcagca gcgacgccac ggcggcgcgg cggccccacc cccgcgggac
    11461 gaggagggcg gcgagcagcg gcgccgcgaa ctgcgtgccg tagcggccgc agccgagcca
    11521 cgtctggtgc acggcggtgg ccatcgcgcg cacgacgccg tcgggcggga cgtcgtgggc
    11581 gcgcagggtg ccgaccatgc cgcccaccgc gccggcgaac ccgcccgcgg cgagcagcgg
    11641 acggccggcc agcagcgcgc cgacggtcag cgcgggccac gggtgcaccc cgagcggcgc
    11701 aagcgcgccc gggtgccgct tcgccagcgg cgcggcggaa gtgccgtagc gggcgcgccg
    11761 gcccagcagg gcgcgccagg tttccggttc gtggtggccg acggtgacgt cgggggcgta
    11821 ccggacccgg tacccggccg cgtgcagccg ccagaccagg tcgacgtcct cgccgacgcg
    11881 cagcgcgggg tcgaacgcgc cggcctcgac gagcgcgctc cggcggacga cgagcgcggc
    11941 ggtcggcacg tacgacgtcc gggtgccggg cgcgacccgc gcgggccggt cgccgaggtc
    12001 gagactggag gcggcgcgcg tgtaccggcc ggccgcggtg tccgcggcga gcgggcacac
    12061 ccggggcgcg accgcggcga cgagcgggtc ggcgaagtgc gcggccagcg gctccaccca
    12121 gccgggcgcg ggcacgcaat cactgtccac aaaggccacc agctcggtgg gaacgtggtc
    12181 cagcgcggtg ttgcgcgcgg cgccggggcc gccgttgacg tcccggcgca cgagtcccgc
    12241 gccgtgcgcg gcggccaccc cggcgatggc ggcggggtct tcggagccgt cgtcgacgat
    12301 gaggacgggg tgccggtcgc cgagtccggc gaggcagcgg gccagaggtc cgggccggcc
    12361 gaggaccggg acgacgaccg tgacgtccgc ggcgcggtcc ggttcgggcg gcagcgggtg
    12421 ggcgagcccg gcgtcggtga ggtgccgggc aagcgcgccg gtggccgcgg aagagaccgg
    12481 gccgtcggcg agttcgcgca gcgcggcctg cccggcggcg gtcaaccgca ggacccgggc
    12541 cggggagccg ccgaagagga ggtcggcggt cagctgcttg gtgtcgcggt cgagggcgat
    12601 gcggaacccg ggtggcaacg gcgtcacagg gccagcccgc cgtccacggg cacgacggcc
    12661 ccggtcacgg ccccgctgtc cggcccggcg aggaacgcca gcacggcggc gacttcgccg
    12721 gcgtcgagca ggcggtgcac gggttgctgc gcggcgaagg cggccgcgtc gggcagggcg
    12781 tagaggcggg cgctttcggc gaggatcggg gtgtcggtcg agcccgggct gacggcgttg
    12841 gcggtcacgc cggtctcccc cagttcggca ccgagcgcgc ggacgagccc ggcgaccccg
    12901 gctttcgcgg cgcagtaggc ggcgagcatg ggcaaccccc gcgtggcggc ggccgaagcg
    12961 acggccagga accgccccga tcgcggtttt ggcctgcgga gcagtgcggg cacggcggcg
    13021 cgggcgaggt ggacgacgcc gtggaggtcg acctccagga cggcccgctc ctggtcttcg
    13081 ggcacctccc acaggggtac tcccccggcg atgaccccgg cggcggcgat ggcgacgtcg
    13141 aggccacccc agcgtcgttc ggcttcccgg acggcggcgg ccatggccgc gggatccctc
    13201 acgtcggcga cgaaagcggc ggcgtgctca ccggcttttt cgacgacggc ggcgaggtcg
    13261 gcttcggtcc ccatgggata gggcagggcg ggctcgtcgg cggccacgtc gacggcgagg
    13321 acggcgtagc cctgctgcgc caggcgcagg acggtggcgg ccccgatccc ccgcgcggcc
    13381 ccggtgacga gcgccgtccg gcgcgtcata cccgcctcca ttcgtccaca tgcgacacca
    13441 gcgcggccgt cagcccggcc agcagttcct tgccttccac cgcggtcgcg ccggtcgggt
    13501 cgccgagcac gccggtcgcc gttaccgccc gcaccccgcc ctcccgcagc aacggcagca
    13561 gctccccgat cgggcgccga tcccccacga ccgctcgttc catccggacg ctgcccggcc
    13621 gcatcgtcag ctgcagagcc gtttccgccc ggcccgcgtg cggctccccc ggccaccgcg
    13681 gccggaacac cgacacgtcc cgcgactccg cccgcaaccg ggccgccgca cgcgtcaccg
    13741 gcccggtgtt gccgccgtgc gcggacacga acagcagccg cccgaacgtc tccgccgccg
    13801 agcggcccag ctccagcagc agcaactccg tcgccccctg gccgatcgac agcgtccccg
    13861 cgaaccccgc gtgctcgccg ctcgagccgt acggcaccgc gggcgccacc aggacttccg
    13921 ggcgggccgc cgccaggccg tcgcacaggg cgagggcgat gtcggtgtcc gtcgtcagcg
    13981 gcaggtgcgg gccgtgctgc tcggtcgcgc cgatcggaac cgccaggatc gcgcccgccg
    14041 ccgcgcgggc ggcgacgccg ggcgaggaca ggtccgcgag gcgcaccatc aggccagcgg
    14101 gttttcgtcg caggggcggc gcatcccgat ggtgaccggg accggacgcc gccggtgcga
    14161 gtggtccagc gacggcttcg ggacgctggt gacacccgcc agcgcgagtt cgccgtggcc
    14221 gcgcacgcac tccgggtccg ggccgtcgag cggcaggccg gtgaagaact tcgcggccat
    14281 gcagccgccg cggcaggcgt cgaacgccga gcacgacgtg cacgcgcccg cgctttgcgg
    14341 gctgcgcagt tccgtgaaca gctcggattc gcgccagacg cgtgtgaagc cgccctcgga
    14401 ccgggtgttg ccggccagga aggtgtcgtg gatggcgaac gggcaggcgt agacgtcgcc
    14461 gaccgggtcg accaggcaca ccacccgccc ggcgccgcac aggttcaggc ccggcagccc
    14521 gccgccgccg tagccggcca ggtggaagaa cgagtcgccg gtgagcacgt tctcgccgtg
    14581 cgccacgagc cagtcgtaga gctcccgctg ctgggcggcg gtcgggtgga gctcgtccca
    14641 ggtgtcggcg ccgcggccgg acgggcgcag ccgcgtgatc cgcagctggg cgcggtagcg
    14701 gtcggcgatc gccttgaacg cgtcgagctg ggcgatgttg tgccgcgtca tgacgaccga
    14761 gatcttgaag ttctcgaaac cggcgtcggc gaggtgctcc atggcgcgga tcgcggtggc
    14821 gtaggagccg gggccgcgga cgtggtcgtt gacctcggcg gtggcgccgt ccagggagat
    14881 ctggacgtcg acgtagtcgc tcccggccag ccgtcgcgcc acttcgggcg tgatcttgac
    14941 gccgttggtg gagaacttga cgccgacgtg gtgcccggtg gcgtagtcga cgagctccca
    15001 gaagtccggg cgcacggtcg gctcgccgcc gccgatgttg acgtagaaga tctgcatgcg
    15061 ctcgaactcg tcgatcagcg ccttgcactc cactgtggac agttcgcgcg ggtcgcgccg
    15121 cccggaggag gaaaggcagt gcacgcagga aaggttgcag gcgtaggtca gttcccaggt
    15181 gaggcagatg ggcgcgtcga gcccgtactg gaattcgtcc acgagggaca tcagagactc
    15241 ctcggctgga tcatccgcga ctcggccagt gcggcgagcg cggcgcggta gcgcggcagc
    15301 tcgggggccg cgaccccggc accggcgcag gcggcgcggg cgctcgggtg cgcgtccagc
    15361 gaccggacga cgtccagcag ggccgggctc ttcaggaacg acaggcggcg ggtgccgaag
    15421 tggtagagca gcgccccgaa ccgttccggc cggatcgcga cccggctgtc gagccgccag
    15481 gccgcgtcca ggtcgaacgg ctcagtagac accgcacatc ccgtcgatcg agacctcctc
    15541 gaccagcagg tcttcggcga cgggggtctc ttcgacgggc tcttcggcga tcttctcggt
    15601 catcgtgact ccttcggcac gggactccta tttcgacaca ctgtgacgaa tatcgagcag
    15661 agtaatgtca cgcagtgtcg gaaacaaccc ccggaaaggg aacggcaccc ggatgaccca
    15721 acgcacgccc gcggcccgcc gcggcaggcc acccggcacg agcgcccgcg agctggaggt
    15781 catcgcgctg cgcctgttca ccgaacgcgg cttccacgag acgacggtcg acgagatcgc
    15841 cgcgaccgcg ggcgtcagcc gccgcacgtt cttccgctac tacgacgcca agtccgacgt
    15901 cctgtggaac gagttcgacg cggaggtcgc cgcgatcacc gagcacctcg ccgcggccga
    15961 cggcaccctg ccggtcctgg acgcggtccg cgaggcggtc atcgcggcca accactaccg
    16021 cgccgaggac gtcacggaac tccgcatgcg catgcacctg ctcagttcgg tcccggaact
    16081 ggcggcgagc gcgacccgcc actacgacgc gtgggagcgc gcggtgagcg cgtacgtcgg
    16141 cgcgcgcacg ggccagccgg cggacgcgct gtacccgctg gcggtcggcc gcgcggtgct
    16201 ggccacgtgc cgcgcggcgt acgagcgctg gtcggcccgc gcggacgcgg acctgacggt
    16261 gtacctggac gcggctctgc gagcgttggc caccggcttc gccgacccgt cccccatcga
    16321 acccgggaac tgagggcggc cgctgaaaaa cagggccgcg ccgattcggc ttcccgcggt
    16381 aacagttcgg ccggggccgg cgacttcggt agcaaccaga ttgcccactg ataccaccgc
    16441 ccgtaacata ttcactgcga tctgccatat tgaggcaggt ccggcgttgg taccccgaag
    16501 tgatctgatc agccgactgg atgcggaggg tgatcgcatg aatgcctgga aaccgtgggc
    16561 agcgacatca acccccgatc ggcgtaatgt gggtagcggg gagtgttctt caaccactcc
    16621 tcaaggccgc tgtggcaccc tccgcacaga ggtcgtccga cgcgaagggt tgacgccatg
    16681 agcacagacg cggcggcgcg cgaacgggaa acccccagcg gacgcggcga gccgatcatc
    16741 ggccaatccc ccaagcggaa agtcggcaac tcggtctacg tttccgtgcc cggccgcgtg
    16801 ccggtcatca aggcgaagcg cgccaagaag gactgacgcc cgccctcagt tcgggtggat
    16861 cgcgtactgc gcggccttgt ccaggctgtc gagcagcagg ttcttggccg ccgaatccag
    16921 cttgctgatc aaggacagat cctcgtccgc cacgcgctcg ccgttggtcc tgatcacgaa
    16981 cgtcgagttg agcgtgatgg cacccaccgt gaggacgtcg gccgggtcct ccccgatcat
    17041 ctggtcactc ccgatcccgg ccagcaggat gggggtggcg aagatccccc gccagatctg
    17101 ggcgatcggg gtcggcgtca ggttcgtcgc ctgcacgttg ccggtgaaga ccgcttgcgc
    17161 ggccgcgaac tccgtttccc ggctgatctt cacgtggtgg cgcaacgacc aatcttcacg
    17221 gtgcgcgtac accgacgtcc cgacgaggtt gaggatgtag cggtgccgct cgtcttcgag
    17281 ttcccggctg cgcagccaca ggaacaggcc gaagttctcg cccgcgccac cgccgagcgg
    17341 atgaccgtac tgccgggcga gttcccgcag gacctgcagc gggccgtcgt cgatttccag
    17401 cgccaggtgc aatcgggtcg tgagttcttc ggcggcctgg ccggtgggga tttccgcgcc
    17461 tttcccgcag cccacgcccg tgtagcagtc gtccagcgcc cgcgtgagcc gccggcggta
    17521 gacgagcgag gcgtcgctct tcacggtggg ccggtaccgc cgcggttcca cgacggcgag
    17581 cgcgagatcc gagatgacct ggttcagctg tgagtaggac ttcaggaaga tcggccggag
    17641 ccccagcttg tcctcgaggt agcgcgccga actgatggcg tagcgagcgg cctcggtcgt
    17701 ggtgactccg ttgacgccgg gcggcaccac cagggagaag cgcggcggcc gcgcctccgc
    17761 ggtcgcgtag agcgggccga tgaggttcgg gtccgacatg cccagcccga tgaagatcgt
    17821 gcaggcaccc tcgagcgcgt tcgagatgac gtcccgcacc tgcgcaccgt gcttcaggaa
    17881 ttgggactcg gtcaggacga tcggctcctc cggatcgccg tcctggcgga ccaggccgtg
    17941 caggtgcatc acgccgatcc ggccgaggcg ccgatcccag gccttccacg cggaactgcc
    18001 gcccggcttg agcgagaacg attccacgtc ttcttcctcg aagtacgccc tcagcgccgc
    18061 ttcgaggatc tcgtcgaagt tcgtcgtcag cagccgcgcc ctcttgccgg cgtacttccg
    18121 gttcgcgcag accagccggg cgatcgaatc cgccagcact cccggcgtgg cgtgcgagtc
    18181 ggaatagagc gctcgccgga tgatcgtgtg gtcctcgacg tcctgcccgc cgtccttcag
    18241 gatctgcagg acgatttcgg ccttccgcat caaatcggaa tcatcgcgca gcgcgatctt
    18301 cttcgtgctc gcgttcttga tctcgttggt catcttgtcg atgaggtccc gccaggacgg
    18361 caggctggag ttcatcgaca ccccggcgcc gacgacgacg gtcagcggct tcttccgcgc
    18421 ccgcacggtt tcgaacagtt cgccgaggta gggctgcgcg tcgaagcaga agatgtcgcc
    18481 ccggtcgaac agatcggggt cgagcattct cgacggagaa ccttcggcca tgcgcaaacc
    18541 tcggtgcatc gtattcgttt cgtccggata tcgcctccgc taggtcgtgc aacgcactgg
    18601 tcctgttaca aggttcccgc acgcacgagt tgtcaactat ttgtccggga atcggaagtg
    18661 tgttcaaccg gttcggccag ctgccacccg cctcggcgcc gcagcaccag gacgtaatac
    18721 cccaccgcca gcaggacgat ccccgccgtc acgatcaggc tcgggcggcc gaccgccggg
    18781 tccacgacgt tctggtacac cacgaacgcc agcaccgcca acgccagcac cggggccacc
    18841 gggaaccacg gcatccggta ctgcgcgtgg gccgtcaccc cggtgcggcg gccgacgatc
    18901 gcacccaggc aaagggccgc gtacaccgcc acgatcgacg tgctcgtcac caccagcagc
    18961 agctgcgggt ccacgaaaca cagcgccgcg gcgacgatcc cggtgccgac cgtcgccacc
    19021 cacggggtgc cgaagcgggg gtggaccgcc gccagggctc ggttgaccgc gcccggccag
    19081 gctcggtcgc ggccgctgct gaagaccagg cgggagctga tcaggacgat cgccaggacc
    19141 gcgttcatga tcgccagcgc caccgccagg ctgagcaccg tgtcgagcgt gctgccgccg
    19201 cgggcggtga tgaacgtcga cagcatgttc tccgagccga acagcgcgcc caggtcgggc
    19261 gcgcccagca ggaccgccgt caccgggacc agctcggcga ccaccgtgat cgccagcgcc
    19321 aggaggatcg cgcgggcgat gccgcgaggg gcgtcctggg tctcctcgcc gaagtacacc
    19381 gccgagccgt agccgttgta ggcgaacatc gccaccgaca tcgcgatcgc gatggcgccg
    19441 atcgtcgcgg ggccgccgcc ggccgccacc gggtgggcga ccaggtcggt gagcgggcgg
    19501 gccgggtgga gcagcccgag cgcgctgacc accaccagcg ccaggatctc gatcgccagg
    19561 aagacgcccg tcacccaggc gttcagcttg atgtcgaaca ccccgacgac ggcggccagc
    19621 acgcacgtca ccgccgcggc cgccgggccg ggcaggcccg ggaacagcac ccccaggtac
    19681 gtcccgacgc cgagcgcgat caccgcgacg atcagcacct gcgtgatgat catcagcccc
    19741 agcacggcga acccgggcag ccgccccagc gtgcgggcca cgatcgcgta ctcgccgccc
    19801 gcgaccggga acgccgaggc gagctcggcg tagacgaagg ccatgaacac gccgaccacc
    19861 gcagcggccg cgaagctgaa gaacgcgccg gtcccggcgc cggcgagcac ccccggcgcg
    19921 atgatgaaca ccgacgacgc ggggctgatc gccgagagcg tgatgagcag ggtgccgagg
    19981 gtgcgcaggc cacggcgcag ggcgggggtg gtcacgagcg ggcctccagt tctttgaagc
    20041 tccttcgaac aaccaggtga ccacgcatca aaggcgctcg tgacagacaa gtcaaggtct
    20101 tgttttttcc gaagttcctt cgaagaatgg ccccatggca cgaccgagca gggcccccga
    20161 acggcgggcc gagctgatcg cggtggcgcg ccgcgccgtc gtcgaacgcg gcatcctcaa
    20221 cctgcggttg cgggacatcg ccgacggcgc cggcctgtcc tcgggctcgg tcctctacta
    20281 cttccccacc ctgaccgacc tcctgcgcga ggtgcagcag gaagccgtcg agcgcttctg
    20341 cacccagcgc gaggacgccg cccggggcgg gacaccgcgc gaacgcctgc tggccacgat
    20401 ccgcagcggc ctgcccaccg gcccgtccga cgaactgtgc gtgctgctct acgaactcgg
    20461 cacgatcgcc cgccgcgacc ccgcctacgc cgcccggcac gtcgccctgt tcgagcggca
    20521 ggtgcggatc tacaccggca tcctcgaagc cggggcggcg accggcgaat tcaccctgac
    20581 cgccgagccg gtcgcgatcg cgcgcaacct cgtcgcgctc gaggacggct acggcctgca
    20641 cctcacccag gcggtgccca cagtggaccg ggccaccgcc gaagcgatgc tgctctcctt
    20701 cgcccgcacc gcctgcagct tggaggacct gtcatgaccc gtgcccgcga cctgggcatc
    20761 accttgcccg gccggcccgg cacgcacaac gcgctcaccg acgtcgccgg cgtcgaagtc
    20821 ggctacacga cggtgctcga aggcgattcg gtgcgcaccg gcgtcaccgc ggtcctcccc
    20881 cgcggccggg cggacttcgc cgtgccgtgc gcggccggga cgttctccct gaacggcaac
    20941 ggcgagatga ccggcaccgc gtggctcgcc gagaccgggt cgctggccct gccggtgctg
    21001 atcaccaaca cccacgccgt cgggccgtgc caccgcggcg tgatcgactg ggtggtgcgc
    21061 gagcgccccg acgtcgccgc ggaatggctg ctgccggtgg tcgccgagac gtgggacggc
    21121 tacctcaacg acatcaacgc cccgacgatc cacagtggat acgcgggcgc ggccctcgac
    21181 gccgcccggg gcggagcgct cgacgaaggt tcggtcggcg gcggcaccgg gatgacctgc
    21241 tacggcttca agggcggcac cggcacggcg tcccggctgg tgccctacgg ttccgacgag
    21301 tacaccgtgg gcgtgctggt gcaggcgaac ttcggcagcc gccgcgagct cacggtcgcg
    21361 ggcgaccacg tgggaccccg gctggcggcg gacgacccga tggcgcactg ggcaccggcc
    21421 ccgcccggcg cgggttcggt catcgtcgtg gtcggcacgg acgcgccgtt gctgccgggg
    21481 cagtgcacgg cgctcgcccg gcgcgtcccg ctcggcctgg cccgcaccgg cacgaccggt
    21541 tcacacttct cgggcgacct gttcctcgcc ttcagcacgg cgaaccccgg cgcgctgacg
    21601 agcgcgttcc cccgcaccgc ggaagccgag tacgagcaac tgcggttcgt gccgtggggc
    21661 cggatcgacc cgttcttcga ggcggtcgtg caggcggtgg aggaagcggt gctcaacgcg
    21721 ctcgtcgcga accgcgagat gaccggccac cgcgggcacc gcgcgcccgc atttccggcc
    21781 gatttttccc ggcggaactg accggaccag cccccgacgg tgcgcccggc ggtccggccg
    21841 cctgggtcac cgccgggtcc actgctggtt ggcgccgccg ccgcaggccc acaggatgat
    21901 cttcgtgccg ttcccggtgg ccgcgccact ggcgtccagg cagagcccgg acaccgcgtt
    21961 cgtgatggtc ccgttcgcgt tcagggtcca ctgctggttg cgccggccgt tgcagtccca
    22021 gctgaccacc gcggttccgt tggcggtgcc gttgtcgtag gcgtccaggc acttcgtgcc
    22081 gttgacgacg agctggccgc gggccggcac ccacgtctgg ttcggtcccc cggcgcagtc
    22141 ccacagctgc gcctggacgc cgttggtgat gctgttgtcg tcgatgtcga ggcaccggcc
    22201 cgactgcgtg ccggccacct ggacgccgtt cgtcccgggc agcggcagga cggcgacgtc
    22261 ggtgagctgc ggtggcgtgc ccgagaacgt gaggttgttg gtgcccttgc ccagggagac
    22321 gacggcggag acggtcctgg ccgctccccc ggtcgccggg aaggcgacga cggtcggctg
    22381 ctggccgttc accgcgaggg tcgcggtccg ggtggtggtc gcgttgtagg tgaaggtcgc
    22441 gacggccgat cccgtcgcgg ccgcggtgat cgtggtgccg tgcgtggccg cggcgtcggt
    22501 gccctggacg gtcagcagca cggagtcgtc ggccgggacg ctcacgctgt atccgttggc
    22561 gtaactgcct tggtcggaag cgctccagag gttccggacc ttcgcggtgg cggcggtgag
    22621 gccgaggtcg gcccaccgcg cggtcatggt cgccgccgac gacgtccggt tgagcagcag
    22681 caccgcgcgt ttcccggagc cggccaggac cttgccgtac acctggagcc cggcggcgtc
    22741 ctcggcgacc ttcacgccct gcaggccgcg cggatcctgg tcgacggcga tgacttcgcg
    22801 gttcttgagg acgttcgccg tctccgtgct catcgtcgcg aggttgttgc ccgcgagcag
    22861 cggcgccccg gagaccgccc acatcccgaa ctcggtccgc ccctgcgcgg cggacagccc
    22921 cggcatcccg acggtcagca tgtcggggtc gttgacgtac ccggtgtgct gcgaaacggg
    22981 gtgctgcgcc tggtcgaagt tggtgagcgc ctgcgggagg gtcgcggtct ggccgtagta
    23041 gatgatgtcc gtgctggtcc gccacatcgg ggcggtgccg gcgccccagt tccacgggtt
    23101 cttcttgccc cagtcgcaga tcgagagggt gagcgtgcgc ccggtctgcg cggtggcggc
    23161 tgtgttggcg tcgctgatcg cccggtaggt gctcgccggg tcgaggcctt cggcgtcgcc
    23221 gccgcaccag tcgaccttga cgaagtcgaa gccccagcgc tggaactgca gcatgtcctg
    23281 caggtagtgg ccttcactgc cggacccggg cgccgcgggc cgcccggtcg ggtagtagta
    23341 cccgcaaccg tcccgcccgg cgtcggtgta gatgcccgcc ttcaacccct tgccgtgcag
    23401 gtaatccgcg atggctttca tcccgccggg ccattcggcg gtgtcgacgg tgatgttgcc
    23461 ggagccgtcg cgggtgccct gccaccagcc ttcgtcgatg ttgacgtagg tgtagccggc
    23521 gtccttgagc ccggtggaga cgagcgcgtc ggcctgcgct ttgatggtgg cgtagtcgat
    23581 cttggcggcg aaggtgttcc aggaggccca gcccatcgcc ggagcgggca ccggcgcctc
    23641 agcggcggcg gcgacccctg cgccggggac gactccggcg aacgccagga gcacggacag
    23701 cagaacgcgc agcttcatcg catcgctccg acctcgtcgt caggaatgtt agcgttaaca
    23761 aacggtgctg gtccagcatt ctgaacggcg ggacgatcgc ccgtcaagcg gcgaacggct
    23821 gaccttcggc agcacctact cgctgagcca ttccgcttcg agatccgcgc actcgaccaa
    23881 gagggtcccg ccggtgaacg cgatctcgtg cgaacagcca ccggcggtcg gaagtatctc
    23941 gtccagctga agatcaccga gactcggaga ggccggccac acgcgcgtgc ccgggcccga
    24001 ccggttcgca tcgagatcga tgttcgtgac gccgtcgtag cggaccacca gaccggagaa
    24061 gtgcttgaac cggttcggca ggaacgtcag ctcggccgcc aacttcgcga accccgcctc
    24121 gcgaacggcc agctgcccca cccggagatc cttgacgcac ctcgaaccgg tgaagtcgta
    24181 gtgatcggag tccgcggcga aggcacgcgc accgaccggg agggcaagtc ccggtagctc
    24241 acgcagatag ggctccggat ccaggaaatt cacgacatcg gcacccccgg tccgagtcac
    24301 ccgcacatag cgcatcaacg accaccggtt ccggtcacgg caatccggtc gaacacggcc
    24361 gaacgccgcc gcggagaccg gcccagcacc agggcgcgat gcacgagacg cccggcgccg
    24421 gcacaggtga gtgcagcggc tttcttcatg atcccccctc ggtcagcaga ttgatcgacc
    24481 cacagcccgc gggtattatc tctagcttgc tagcatgcta ggatcgacca cgtgggcgat
    24541 gacgacgtca aacagttcaa cgtgtacctg ccgatcggcc tgatccggca gctcaagcac
    24601 cgagccgtcg aaaccgaaca atcgctgtcg gcgctcgtcg ccgaagcgct gcgcgcctat
    24661 ctaggaaccg aagaggagca ctgaacatga cgaccgaggg catcgacgcc gtgtacctgg
    24721 agacgcacaa ctggggcaag gccgccaagt tcttccaagc actgggctac gaaatcgact
    24781 tcgcgaccga ccacaactcg gggctgctcc gcaacggcga cggaccccat ttgttcatcg
    24841 ccgaggtacc cgggagccag gaaccgcggc agcaggtcgt cttcaaggtc ccggacgccg
    24901 acgccttccg ggccgacgac atcgtcgaag tgatcacccc gttcgaagac acccactacg
    24961 ggacccgcga gatgaccgtc cgcgatccgg acgggcggac ctggacgctc tccgcgccgg
    25021 cggcgggctg acgatgaccg cgccggacag caccgcggcg cggaccgcct tgtggcgggc
    25081 gctgcacgtc gccgtcgatc cgccgccgca cgtgttcgac gacgaactcg ggctgcggct
    25141 ggccgatccg ggcgagggct ggcgggaccg ggacgacatg gacccggcca ccgccgggcg
    25201 gtaccgggcc gggatggtcg cgcgggcgcg gttcgtcgaa gatctcgtcg tcgaccaggc
    25261 gagccgcggg gtcgggcagt acgtcctcct cggggccggg ctggacacct tcgcccagcg
    25321 ccgcccggaa gtcgcggcgc ggctgcgcgt gttcgaggtc gaccagcccg gcccgcaggc
    25381 ctggaaacgc gcgcgcctcg acgaactcgg cctcggcgtc cccgagtggc tgcggctggt
    25441 gccggtcgac ttcgagacca cgtcgtggtg ggaccggctc acggacgcgg gtttcgcggc
    25501 ggacgaaccc gc
//
