GCF_022983255.1 - 11 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP095274.1 (Clavibacter michiganensis subsp. michiganensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	NRPS-like	161,046	204,441
Region 1.2	NRP-metallophore,NRPS	389,141	445,573	High	coelibactin	NRPS:Type I
Region 1.3	NAPAA	719,898	754,067	High	ε-Poly-L-lysine	NRPS:Type I
Region 1.4	lipolanthine,lanthipeptide-class-iii	782,153	811,760
Region 1.5	hydrogen-cyanide	927,758	941,001
Region 1.6	T3PKS	1,731,614	1,772,834
Region 1.7	terpene-precursor,betalactone	2,118,170	2,153,844
Region 1.8	lanthipeptide-class-ii	2,226,573	2,249,734	High	michiganin A	ribosomal:RiPP:Lanthipeptide
Region 1.9	NI-siderophore	2,365,414	2,395,930	Low	legonoxamine A/desferrioxamine B/legonoxamine B	other:other
Region 1.10	azole-containing-RiPP	3,124,460	3,146,749
Region 1.11	terpene	3,229,127	3,253,548	Low	carotenoid	terpene

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	NRPS-like	161,046	204,441
Region 1.2	NRP-metallophore,NRPS	389,141	445,573	High	coelibactin	NRPS:Type I
Region 1.3	NAPAA	719,898	754,067	High	ε-Poly-L-lysine	NRPS:Type I
Region 1.4	lipolanthine,lanthipeptide-class-iii	782,153	811,760
Region 1.5	hydrogen-cyanide	927,758	941,001
Region 1.6	T3PKS	1,731,614	1,772,834
Region 1.7	terpene-precursor,betalactone	2,118,170	2,153,844
Region 1.8	lanthipeptide-class-ii	2,226,573	2,249,734	High	michiganin A	ribosomal:RiPP:Lanthipeptide
Region 1.9	NI-siderophore	2,365,414	2,395,930	Low	legonoxamine A/desferrioxamine B/legonoxamine B	other:other
Region 1.10	azole-containing-RiPP	3,124,460	3,146,749
Region 1.11	terpene	3,229,127	3,253,548	Low	carotenoid	terpene

No secondary metabolite regions were found in these records:: NZ_CP095275.1 (Clavibacter michiganensis subsp. michiganensis)

Compact view

NZ_CP095274.1 - Region 1 - NRPS-like

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Location: 161,046 - 204,441 nt. (total: 43,396 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

MU580_RS00735: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: PPTase carboxylase

MU580_RS00775: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

MU580_RS00800: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase

MU580_RS00740: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: dehydratase

MU580_RS00795: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease transporter

MU580_RS00720: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

MU580_RS00790: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000893.5	0.45	NRPS	chloramphenicol	Streptomyces venezuelae ATCC 10712
BGC0001873.3	0.44	NRPS	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001948.3	0.42	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0001377.5	0.42	PKS	uncialamycin	Streptomyces uncialis
BGC0000234.5	0.42	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001441.5	0.42	other (other)	belactosin A, belactosin C	Streptomyces sp.
BGC0002387.2	0.41	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0001500.3	0.41	PKS	allocyclinone A, allocyclinone B, allocyclinone C, allocyclinone D	Actinoallomurus sp. ID145698
BGC0000275.4	0.41	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001850.4	0.40	other (shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000893.5	0.45	NRPS	chloramphenicol	Streptomyces venezuelae ATCC 10712
BGC0001873.3	0.44	NRPS	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001948.3	0.42	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0001377.5	0.42	PKS	uncialamycin	Streptomyces uncialis
BGC0000234.5	0.42	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001441.5	0.42	other (other)	belactosin A, belactosin C	Streptomyces sp.
BGC0002387.2	0.41	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0001500.3	0.41	PKS	allocyclinone A, allocyclinone B, allocyclinone C, allocyclinone D	Actinoallomurus sp. ID145698
BGC0000275.4	0.41	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001850.4	0.40	other (shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (10):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.52 out of 21.55

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.99 out of 30.97

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.19 out of 28.14

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.17 out of 35.63

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.60 out of 30.11

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.00 out of 20.01

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.79 out of 19.52

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 161045 - 204441:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

MU580_RS00795: X

AMP-binding (24..465): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: RHALHLTGRSSAVFICTSAHDLYGSTEAGGILHD
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description

NZ_CP095274.1 - Region 2 - NRP-metallophore,NRPS

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Location: 389,141 - 445,573 nt. (total: 56,433 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

MU580_RS01885: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

MU580_RS01905: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: PPTase acetyltransferase kinase

MU580_RS01870: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

MU580_RS01965: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

MU580_RS02055: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Hydrolases: esterase

MU580_RS01935: thioesterase

smcogs: SMCOG1004: thioesterase

Isomerases: isomerase

MU580_RS01970: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

MU580_RS01880: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

MU580_RS01955: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MU580_RS01960: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transporter

MU580_RS02060: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000412.5	0.63	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0001833.4	0.61	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.60	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.58	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.58	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	0.58	NRPS	HC-toxin	Alternaria jesenskae
BGC0000307.4	0.57	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000412.5	0.65	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.64	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	0.62	NRPS	HC-toxin	Alternaria jesenskae
BGC0000307.4	0.62	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.92 out of 32.74

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.79 out of 25.31

Confidence: medium

Additional weak hits (21):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.53 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.30 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.04 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.09 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.25 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.56 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.18 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.16 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.32 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.65 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.67 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.20 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.68 out of 29.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.29 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.28 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 14.87 out of 31.73

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.86 out of 30.22

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.39 out of 29.65

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.17 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.03 out of 28.19

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.30 out of 20.01

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 389140 - 445573:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - Cys) + (Me-Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

MU580_RS01950: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (543..955): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDIAFDLSVFDGNSLLSGDVSLGGATEAAIWSVH
Nearest Stachelhaus code(s):: Cys DLFNLSLIWK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

MU580_RS01955: Ser - Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (588..991): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TSLSFDLSVYDANTLLGGDLALGGMTEATIHSTV
Nearest Stachelhaus code(s):: Ser DLYNLGLIHK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1653..2052): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TAVSFDLSVFDGDTLVSGDVALGGATEAAIWSNA
Nearest Stachelhaus code(s):: Cys DLFNLSLIWK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)

MU580_RS01960: X

AMP-binding (44..464): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: NAALFTLACPGGALQVGGAQQVYGMAEGLVCMTG
Nearest Stachelhaus code(s):: Sal TLPAQGVICK (79% 8Å match); n-oh-nitropheBut TLPSQGVVCK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
FuR variant 2	Ferric Uptake Regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP095274.1 - Region 3 - NAPAA

Download region GenBank file

Download region SVG

Location: 719,898 - 754,067 nt. (total: 34,170 nt) Show pHMM detection rules used

NAPAA: (AMP-binding and TIGR02353)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

MU580_RS03490: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

MU580_RS03600: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: PPTase aminotransferase

MU580_RS03500: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

MU580_RS03535: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Lyases: dehydratase

MU580_RS03560: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase

MU580_RS03510: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002174.2	0.77	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0002276.2	0.62	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001833.4	0.59	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001132.4	0.59	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002174.2	0.77	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0002276.2	0.62	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001833.4	0.59	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001132.4	0.59	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 24.94 out of 30.11

Confidence: medium

Additional weak hits (6):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.07 out of 33.73

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.76 out of 21.84

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.06 out of 28.19

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.71 out of 27.18

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.02 out of 26.85

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 3, location 719897 - 754067:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

MU580_RS03510: X

AMP-binding (56..456): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FAELFDASCEELSTIFGGEWNTYGPTEATVVACA
Nearest Stachelhaus code(s):: Lys DAEDIGTVVK (71% 8Å match); Gln or Tyr DAESVGTVVK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CelR	Cellobiose uptake repressor

NZ_CP095274.1 - Region 4 - lanthipeptide-class-iii,lipolanthine

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Location: 782,153 - 811,760 nt. (total: 29,608 nt) Show pHMM detection rules used

lipolanthine: (micKC and Flavoprotein)
lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

MU580_RS03830: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

MU580_RS03855: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase

MU580_RS03815: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase

MU580_RS03895: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: ligase synthase

MU580_RS03820: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MU580_RS03825: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000513.3	0.32	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.31	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0002711.2	0.30	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001152.5	0.27	NRPS, PKS	fusaricidin B	Paenibacillus polymyxa
BGC0000520.5	0.26	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000255.5	0.26	PKS	pederin	Uncultured bacterium
BGC0000516.4	0.25	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000626.3	0.24	ribosomal	thuricin	Bacillus thuringiensis
BGC0000546.3	0.24	ribosomal	SAL-2242	Streptomyces albidoflavus
BGC0002591.2	0.24	PKS, terpene	aurachin C, aurachin D, aurachin SS	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002711.2	0.47	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000513.3	0.46	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.46	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001152.5	0.45	NRPS, PKS	fusaricidin B	Paenibacillus polymyxa
BGC0000255.5	0.44	PKS	pederin	Uncultured bacterium
BGC0001869.4	0.42	NRPS, other (phenazine)	griseoluteic acid, demethoxygriseoluteic acid, phenaszentine A, phenaszentine C, phenaszenketide C, phenaszenketide D	Xenorhabdus szentirmaii DSM 16338
BGC0000516.4	0.42	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000520.5	0.42	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0001895.4	0.42	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002591.2	0.41	PKS, terpene	aurachin C, aurachin D, aurachin SS	Streptomyces sp.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.53 out of 21.84

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.36 out of 21.84

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.99 out of 26.85

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description

NZ_CP095274.1 - Region 5 - hydrogen-cyanide

Download region GenBank file

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Location: 927,758 - 941,001 nt. (total: 13,244 nt) Show pHMM detection rules used

hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

MU580_RS04455: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

MU580_RS04480: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Hydrolases: peptidase

MU580_RS04445: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.53	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000538.3	0.39	ribosomal	nisin Z	Lactococcus lactis
BGC0002382.3	0.39	ribosomal	grimoviridin	Grimontia marina
BGC0001289.5	0.39	ribosomal	penisin	Paenibacillus ehimensis
BGC0000500.5	0.39	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002064.2	0.37	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0000497.3	0.37	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000541.5	0.37	ribosomal	paenicidin A	Paenibacillus polymyxa

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.53	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000538.3	0.39	ribosomal	nisin Z	Lactococcus lactis
BGC0002382.3	0.39	ribosomal	grimoviridin	Grimontia marina
BGC0001289.5	0.39	ribosomal	penisin	Paenibacillus ehimensis
BGC0000500.5	0.39	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002064.2	0.37	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0000497.3	0.37	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000541.5	0.37	ribosomal	paenicidin A	Paenibacillus polymyxa

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.57 out of 26.33

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP095274.1 - Region 6 - T3PKS

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Location: 1,731,614 - 1,772,834 nt. (total: 41,221 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

MU580_RS08185: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

MU580_RS08235: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: acetyltransferase

MU580_RS08250: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase

MU580_RS08135: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Isomerases: isomerase

MU580_RS08285: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: synthase

MU580_RS08225: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.3	0.51	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001905.4	0.51	PKS	violapyrone B	Streptomyces somaliensis
BGC0002332.2	0.50	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001077.4	0.50	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0001831.3	0.46	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001529.5	0.45	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0002362.3	0.43	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0002151.2	0.43	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.3	0.51	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001905.4	0.51	PKS	violapyrone B	Streptomyces somaliensis
BGC0002332.2	0.50	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001077.4	0.50	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0001831.3	0.46	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001529.5	0.45	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0002362.3	0.43	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0002151.2	0.43	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 26.01 out of 29.65

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.65 out of 24.78

Confidence: medium

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 24.83 out of 29.65

Confidence: medium

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 26.01 out of 29.65

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.65 out of 24.78

Confidence: medium

Additional weak hits (6):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.03 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.21 out of 24.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.31 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.56 out of 28.14

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.53 out of 21.84

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
LexA variant 1	Repressor of DNA damage response
LexA variant 2	Repressor of DNA damage response

NZ_CP095274.1 - Region 7 - betalactone,terpene-precursor

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Location: 2,118,170 - 2,153,844 nt. (total: 35,675 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

MU580_RS10015: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acyltransferase carboxylase

MU580_RS09995: acyltransferase

smcogs: SMCOG1141: acyltransferase

MU580_RS10020: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: deformylase

MU580_RS10010: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

Ligases: ligase synthetase

MU580_RS09970: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

MU580_RS10005: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.31	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002309.2	0.29	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001911.3	0.26	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.26	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000664.5	0.26	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.26	terpene	isorenieratene	Streptomyces argillaceus
BGC0002561.3	0.25	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000633.3	0.25	terpene	carotenoid	Streptomyces avermitilis
BGC0000936.5	0.25	other (other)	pyocyanine	Pseudomonas aeruginosa PAO1
BGC0000649.3	0.25	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002309.2	0.47	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5	0.46	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001911.3	0.43	terpene	raimonol	Streptomyces anulatus
BGC0000649.3	0.43	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002284.3	0.43	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001910.4	0.43	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000664.5	0.43	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.42	terpene	isorenieratene	Streptomyces argillaceus
BGC0002561.3	0.42	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000678.5	0.42	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

MU580_RS09970: PT_FPPS_like

Domain 1 (45 - 371): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.21 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.77 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

NZ_CP095274.1 - Region 8 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 2,226,573 - 2,249,734 nt. (total: 23,162 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

MU580_RS10465: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	1.00	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.4	0.50	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000527.5	0.48	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000503.5	0.48	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002346.3	0.47	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000525.5	0.44	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000539.5	0.44	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001787.3	0.44	ribosomal	suicin 3908	Streptococcus suis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	1.00	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.4	0.50	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000527.5	0.48	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000503.5	0.48	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002346.3	0.47	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000525.5	0.44	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000539.5	0.44	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001787.3	0.44	ribosomal	suicin 3908	Streptococcus suis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for MU580_RS10465

MU580_RS10460

Leader:

MNDILETETPVMVSPRWDMLLDAGEDTSPSVQTQIDAEFRRVVSPYM

Core:

SSSGWLCTLTIECGTIICACR

Core with dehydrations:

DhaDhaDhaGWLCysDhbLDhbIECysGDhbIICysACysR

antiSMASH-DB 4.0 matches for MU580_RS10460

100.0%

NC_009480.1and 10 others:

NZ_CP033724.1 Lanthipeptides: EFE39_RS10220_lanthipeptideNZ_CP047051.1 Lanthipeptides: GRD74_RS10365_lanthipeptideNZ_CP047054.1 Lanthipeptides: GRD61_RS10460_lanthipeptideNZ_CP053860.1 Lanthipeptides: DQP62_RS10825_lanthipeptideNZ_CP076352.1 Lanthipeptides: KN218_RS09900_lanthipeptideNZ_CP085137.1 Lanthipeptides: LHJ48_RS10290_lanthipeptideNZ_CP085140.1 Lanthipeptides: LHJ47_RS10305_lanthipeptideNZ_CP095274.1 Lanthipeptides: MU580_RS10460_lanthipeptideNZ_PSTW01000024.1 Lanthipeptides: C5C03_RS09675_lanthipeptideNZ_SISU01000002.1 Lanthipeptides: EOG37_RS09890_lanthipeptide

Lanthipeptides: CMM_RS10575_lanthipeptide

1

SSSGWLCTLTIECGTIICACR

21

SSSGWLCTLTIECGTIICACR

1

SSSGWLCTLTIECGTIICACR

21

90.5%

NZ_CP028130.1:

Lanthipeptides: C7V51_RS14690_lanthipeptide

2

SSGWLCTLTIECGTIICACR

21

SSGW+CTLTIECGTIICACR

2

SSGWMCTLTIECGTIICACR

21

90.5%

NZ_CP061274.1and 1 other:

NZ_JADKRR010000001.1 Lanthipeptides: ITJ40_RS10085_lanthipeptide

Lanthipeptides: H9X71_RS09850_lanthipeptide

1

SSSGWLCTLTIECGTIICACR

21

+SSGWLCTLTIECGT ICACR

1

ASSGWLCTLTIECGTFICACR

21

with 109 more sequence matches

Only the first 10 are displayed here.

85.7%

NZ_AUBN01000022.1:

Lanthipeptides: G448_RS16025_lanthipeptide

1

SSSGWLCTLTIECGTIICACR

21

+SSGW CTLTIECGT ICACR

1

ASSGWFCTLTIECGTFICACR

21

81.0%

NZ_CP015515.1and 1 other:

NZ_PSUO01000011.1 Lanthipeptides: C5C18_RS08595_lanthipeptide

Lanthipeptides: A6122_RS12855_lanthipeptide

2

SSGWLCTLTIECGTIICACR

21

SSGW+CTLTIECGT++CACR

2

SSGWMCTLTIECGTVVCACR

21

81.0%

NZ_JAGPXN010000019.1:

Lanthipeptides: KBX06_RS22045_lanthipeptide

2

SSGWLCTLTIECGTIICACR

21

SSGW+CTLTIECGT++CACR

1

SSGWVCTLTIECGTVVCACR

20

76.2%

NZ_CP036455.1:

Lanthipeptides: EKD16_RS25235_lanthipeptide

2

SSGWLCTLTIECGTIICACR

21

SSGW+CTLTIECGT++CAC+

1

SSGWVCTLTIECGTLVCACQ

20

76.2%

NZ_JAODUN010000003.1:

Lanthipeptides: BXY51_RS10560_lanthipeptide

2

SSGWLCTLTIECGTIICAC

20

SSGW+CTLTIECGT++CAC

1

SSGWVCTLTIECGTLVCAC

19

76.2%

NZ_KB895893.1and 1 other:

NZ_KB900614.1 Lanthipeptides: SALPAC6_RS0114155_lanthipeptide

Lanthipeptides: C569_RS0129325_lanthipeptide

2

SSGWLCTLTIECGTIICACR

21

SSGW+CTLTIECGT++CAC+

1

SSGWVCTLTIECGTVVCACQ

20

40.9%

NZ_CP034669.1:

Lanthipeptides: EJ065_RS32040_lanthipeptide

1

SSSGWLCTLTIECG

14

+S G++CTLT ECG

8

NSCGYVCTLTTECG

21

40.9%

NZ_NIHT01000008.1and 1 other:

NZ_NIHT01000008.1 Lanthipeptides: CDL23_RS06740_lanthipeptide

Lanthipeptides: CDL23_RS06745_lanthipeptide

1

SSSGWLCTLTIECGTIICAC

20

+ SGWL T+T +C I C

2

NGSGWLPTITDDCPNSIFVC

21

38.1%

NZ_CP022413.2and 1 other:

NZ_JAQEYW010000009.1 Lanthipeptides: PG422_RS09400_lanthipeptide

Lanthipeptides: CGC63_RS01420_lanthipeptide

3

SGWLCTLTIECGTII

17

SG +CT+++ECG+I

1

SGVVCTISVECGSIF

15

38.1%

NZ_CP036073.1and 11 others:

NZ_CP036073.1 Lanthipeptides: EXW45_RS04930_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04925_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04920_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04915_lanthipeptideNZ_CP036073.1 Lanthipeptides: EXW45_RS04910_lanthipeptideNZ_NUEG01000031.1 Lanthipeptides: CN905_RS18915_lanthipeptideNZ_NUEG01000031.1 Lanthipeptides: CN905_RS18910_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05275_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05270_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05265_lanthipeptideNZ_PVRT01000001.1 Lanthipeptides: C6359_RS05260_lanthipeptide

Lanthipeptides: EXW45_RS04935_lanthipeptide

4

GWLCTLTIECGTIICAC

20

GWLCT+T +C + C

4

GWLCTVTDDCPNSVFVC

20

MIBiG 4.0 matches for MU580_RS10460

26.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

SSSGWLCTLTIEC

13

++ GW CTLT EC

14

NNGGW-CTLTKEC

25

25.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

2

SSGWLCTLTIEC

13

+ G CTLT+EC

12

NKGAYCTLTVEC

23

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

7

CTLTIEC

13

CTL+ EC

28

CTLSKEC

34

allorf_2244227_2244355

Leader:

MLLMSLTSLPAS

Core:

ATATATATATATRSCTCTCTCTCTGESWNI

Core with dehydrations:

ADhbADhbADhbADhbADhbADhbRDhaCysDhbCysDhbCysDhbCysDhbCysDhbGEDhaWNI

antiSMASH-DB 4.0 matches for allorf_2244227_2244355

100.0%

NZ_CP095274.1:

Lanthipeptides: allorf_2244227_2244355_lanthipeptide

1

ATATATATATATRSCTCTCTCTCTGESWNI

30

ATATATATATATRSCTCTCTCTCTGESWNI

1

ATATATATATATRSCTCTCTCTCTGESWNI

30

26.7%

NZ_JAEQNB010000006.1:

Lanthipeptides: JJB07_RS18750_lanthipeptide

16

TCTCTCTCTGESWN

29

TCTC CT +G W

11

TCTCLCTISGCDWR

24

23.3%

NZ_CP022163.1:

Lanthipeptides: MEBOL_RS31095_lanthipeptide

3

ATATATATATRSCTCTCTC

21

T +T T +++ C CTC

5

PTTVSTGTGSKNPPCQCTC

23

with 2 more sequence matches

18.9%

NZ_KB913021.1:

Lanthipeptides: NATTI_RS0124330_lanthipeptide

1

ATATATATATATRSCTCTCTCTCT

24

A T + A + TC CTC CT

27

ALEVMTEISEAKYTFTCICTCKCT

50

17.0%

NZ_KZ859514.1:

Lanthipeptides: DPQ64_RS19145_lanthipeptide

6

TATATATRSCTCTCTCTCT

24

T T S C+CTC C+

20

TEKITGIWSLDCSCTCMCS

38

MIBiG 4.0 matches for allorf_2244227_2244355

13.3%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

20

TCTCTG

25

TC C G

2

TCECVG

7

13.3%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

14

SCTCTC

19

SC C C

1

SCNCVC

6

allorf_2244352_2244492

Leader:

MWVLARPIRALLARCQLAFA

Core:

TVFTSGPSHRKVTARLLCQRASSPKR

Core with dehydrations:

DhbVFDhbDhaGPDhaHRKVDhbARLLCysQRADhaDhaPKR

antiSMASH-DB 4.0 matches for allorf_2244352_2244492

100.0%

NZ_CP095274.1:

Lanthipeptides: allorf_2244352_2244492_lanthipeptide

1

TVFTSGPSHRKVTARLLCQRASSPKR

26

TVFTSGPSHRKVTARLLCQRASSPKR

1

TVFTSGPSHRKVTARLLCQRASSPKR

26

19.2%

NZ_LIVW01000004.1:

Lanthipeptides: allorf_700442_700657_lanthipeptide

9

HRKVTARLLCQRASSP

24

HR+ R++C ++P

1

HREAVRRVICSDRNAP

16

17.0%

NZ_CP013140.1:

Lanthipeptides: allorf_2947523_2947699_lanthipeptide

13

TARLLCQRASSPKR

26

AR +C RASS +R

29

AARRMCGRASSAQR

42

with 1 more sequence matches

15.8%

NZ_LMHM01000013.1:

Lanthipeptides: allorf_293905_294090_lanthipeptide

9

HRKVTARLLCQRASSP

24

R+V R +C+R +P

17

DRRVNDRPVCKRGRAP

32

allorf_2246823_2246945

Leader:

MRVWVCSPVRKPSHGG

Core:

KAERRVRRCTIRRPVLPIQFSRRR

Core with dehydrations:

KAERRVRRCysDhbIRRPVLPIQFDhaRRR

antiSMASH-DB 4.0 matches for allorf_2246823_2246945

100.0%

NZ_CP095274.1:

Lanthipeptides: allorf_2246823_2246945_lanthipeptide

1

KAERRVRRCTIRRPVLPIQFSRRR

24

KAERRVRRCTIRRPVLPIQFSRRR

1

KAERRVRRCTIRRPVLPIQFSRRR

24

28.0%

NZ_JAGGRJ010000002.1:

Lanthipeptides: allorf_29706_29855_lanthipeptide

7

RRCTIRRPVLPIQ

19

+ C IRRP P+Q

9

KGCEIRRPRTPLQ

21

18.5%

NZ_CP012673.1:

Lanthipeptides: SOCE26_RS54770_lanthipeptide

9

CTIRRPVLPI

18

CT RP P+

15

CTTGRPAWPL

24

with 1 more sequence matches

17.1%

NZ_FWXV01000001.1:

Lanthipeptides: B9C43_RS03005_lanthipeptide

4

RRVRRCTIRRPVL

16

R CT RPV

21

SRCSSCTASRPVF

33

allorf_2246863_2247063

Leader:

MGVKLNGVCVDAPYGGPSCPSSSLDAVDRDRTTAAM

Core:

MCSTVSCAGSCSRYRRTVRRRPWRLAVALT

Core with dehydrations:

MCysDhaDhbVDhaCysAGDhaCysDhaRYRRDhbVRRRPWRLAVALDhb

antiSMASH-DB 4.0 matches for allorf_2246863_2247063

100.0%

NZ_CP095274.1:

Lanthipeptides: allorf_2246863_2247063_lanthipeptide

1

MCSTVSCAGSCSRYRRTVRRRPWRLAVALT

30

MCSTVSCAGSCSRYRRTVRRRPWRLAVALT

1

MCSTVSCAGSCSRYRRTVRRRPWRLAVALT

30

24.2%

NZ_CP029560.1and 1 other:

NZ_JADOZM010000015.1 Lanthipeptides: allorf_00761_00913_lanthipeptide

Lanthipeptides: allorf_0494409_0494561_lanthipeptide

4

TVSCAGSCSRYRRTVRR

20

++ CAGSC R +V R

16

SIGCAGSCVRSTISVYR

32

20.9%

NZ_JAPVBQ010000001.1:

Lanthipeptides: O2V63_RS05715_lanthipeptide

4

TVSCAGSCSRYRRTVRRRPWRLAVAL

29

+V C + R RRRP+R +A+

4

SVLCLRGSAEQDRAGRRRPYRAFMAI

29

with 4 more sequence matches

20.0%

NC_016109.1:

Lanthipeptides: KSE_RS45575_lanthipeptide

4

TVSCAGSCSR

13

++SC GSC+R

2

SLSCEGSCTR

11

17.1%

NZ_CP113114.1and 1 other:

NZ_FZDV01000015.1 Lanthipeptides: CFW84_RS08635_lanthipeptide

Lanthipeptides: OTU45_RS07045_lanthipeptide

3

STVSCAGSCSRY

14

+T+SC G CS +

21

NTISCNGHCSIH

32

16.7%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12785_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15570_lanthipeptide

Lanthipeptides: GTU71_RS12785_lanthipeptide

1

MCSTVSCAGSC

11

+C T SC G C

26

LCPTFSCTGEC

36

13.6%

NZ_CP098485.1:

Lanthipeptides: allorf_6386562_6386786_lanthipeptide

3

STVSCAGSCSR-YRRTVRR

20

S + AG C YR T+RR

15

SPIGPAGGCGEAYRGTIRR

33

MIBiG 4.0 matches for allorf_2246863_2247063

16.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

4

TVSCAGSCS

12

TV C SC+

20

TVECMPSCN

28

allorf_2247381_2247521

Leader:

MGQRAVAQLGS

Core:

ALDWGSRGRRFKSCQPDGHASEGPMGPAGAFVILG

Core with dehydrations:

ALDWGDhaRGRRFKDhaCysQPDGHADhaEGPMGPAGAFVILG

antiSMASH-DB 4.0 matches for allorf_2247381_2247521

100.0%

NZ_CP095274.1:

Lanthipeptides: allorf_2247381_2247521_lanthipeptide

1

ALDWGSRGRRFKSCQPDGHASEGPMGPAGAFVILG

35

ALDWGSRGRRFKSCQPDGHASEGPMGPAGAFVILG

1

ALDWGSRGRRFKSCQPDGHASEGPMGPAGAFVILG

35

68.8%

NZ_CP033724.1and 2 others:

NZ_CP085137.1 Lanthipeptides: allorf_2198282_2198461_lanthipeptideNZ_CP085140.1 Lanthipeptides: allorf_2198287_2198466_lanthipeptide

Lanthipeptides: allorf_2198300_2198479_lanthipeptide

1

ALDWGSRGRRFKSCQPDGHASEGPMGPAGAFVI

33

ALDWGSRGRRFKSCQPDGHASEGPMGPAGAFVI

1

ALDWGSRGRRFKSCQPDGHASEGPMGPAGAFVI

33

66.7%

NZ_CP047051.1and 1 other:

NZ_CP076352.1 Lanthipeptides: allorf_2115916_2116095_lanthipeptide

Lanthipeptides: allorf_2221797_2221976_lanthipeptide

1

ALDWGSRGRRFKSCQPDGHASEGPMGPAGAFVIL

34

ALDWGSRGRRFKSCQPDGHASEGP GPAGAFV+L

1

ALDWGSRGRRFKSCQPDGHASEGPSGPAGAFVVL

34

with 6 more sequence matches

56.0%

NZ_SISU01000002.1:

Lanthipeptides: allorf_784456_784641_lanthipeptide

1

ALDWGSRGRRFKSCQPDGHASEGPMGPAGAFVI

33

ALDWGSRGRRFKSCQPDGHASEGP GP+ AF +

1

ALDWGSRGRRFKSCQPDGHASEGPNGPSEAFFV

33

51.0%

NZ_JADKRR010000001.1:

Lanthipeptides: allorf_2147485_2147667_lanthipeptide

1

ALDWGSRGRRFKSCQPDGHASEGPMG

26

ALDWGSRGRRFKSCQPDGHASEGP G

1

ALDWGSRGRRFKSCQPDGHASEGPDG

26

28.6%

NZ_AP022871.1:

Lanthipeptides: allorf_10021069_10021233_lanthipeptide

5

GSRGRRFKSCQPDGHASEG

23

G+RG R SC P G S G

2

GARGARTSSCVPRGSLSGG

20

26.3%

NZ_JAEDVW010000007.1:

Lanthipeptides: allorf_22564_22716_lanthipeptide

4

WGSRGRRFKSCQPDGHASEGPMGPAGAFV

32

W R RR HAS+ P P G

3

WSCRVRRT------AHASKAPSSPHGEVT

25

25.7%

NZ_CP071090.1:

Lanthipeptides: allorf_11048315_11048452_lanthipeptide

5

GSRGRRFKSCQPDGHASEGPMGPAGAFV

32

G R R KS Q HA + + +V

1

GERPRVCKSIQAPTHAMRCTVVTSKTYV

28

22.9%

NZ_JADKRR010000001.1:

Lanthipeptides: allorf_2147511_2147642_lanthipeptide

25

MGPAGAFVI

33

MGPAGAFV+

14

MGPAGAFVV

22

MIBiG 4.0 matches for allorf_2247381_2247521

10.3%

BGC0001229.4 (SBI_06990)and 1 other:

BGC0002110.3 (QKV49893.1) Lanthipeptide: birimositide

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

12

KSCQPDGH

19

K CQP+ +

32

KECQPNCN

39

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.46 out of 27.55

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.48 out of 23.79

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.00 out of 27.18

Confidence: medium

Additional weak hits (13):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.23 out of 25.88

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.02 out of 29.38

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.07 out of 36.54

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.63 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.83 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.81 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.53 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.76 out of 30.25

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.19 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.10 out of 26.06

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.44 out of 26.85

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

MU580_RS10460 - Class II

Cleavage pHMM score: -3.60

RODEO score: 0

Monoisotopic mass: 2108.0 Da

Molecular weight: 2109.5 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2127.5 Da N = 1; 2145.5 Da N = 2

allorf_2244227_2244355 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 2766.2 Da

Molecular weight: 2768.1 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 2786.1 Da N = 1; 2804.1 Da N = 2; 2822.1 Da N = 3; 2840.1 Da N = 4; 2858.2 Da N = 5; 2876.2 Da N = 6; 2894.2 Da N = 7; 2912.2 Da N = 8

allorf_2244352_2244492 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 2756.6 Da

Molecular weight: 2758.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2776.2 Da N = 1; 2794.2 Da N = 2; 2812.2 Da N = 3; 2830.3 Da N = 4; 2848.3 Da N = 5; 2866.3 Da N = 6

allorf_2246823_2246945 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 3012.8 Da

Molecular weight: 3014.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3032.6 Da N = 1

allorf_2246863_2247063 - Class II

Cleavage pHMM score: -4.30

RODEO score: 0

Monoisotopic mass: 3315.8 Da

Molecular weight: 3317.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3335.9 Da N = 1; 3354.0 Da N = 2; 3372.0 Da N = 3; 3390.0 Da N = 4

allorf_2247381_2247521 - Class II

Cleavage pHMM score: -5.70

RODEO score: 0

Monoisotopic mass: 3572.8 Da

Molecular weight: 3575.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3593.0 Da N = 1; 3611.0 Da N = 2

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
NrdR	Represses ribonucleotide reductase encoding genes

NZ_CP095274.1 - Region 9 - NI-siderophore

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Location: 2,365,414 - 2,395,930 nt. (total: 30,517 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

MU580_RS11105: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

MU580_RS11120: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

MU580_RS11140: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

MU580_RS11170: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase

MU580_RS11090: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: decarboxylase

MU580_RS11145: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.3	0.69	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0001478.5	0.66	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.3	0.64	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2	0.61	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001453.5	0.60	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0000244.4	0.60	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0000940.5	0.60	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0002620.2	0.57	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002690.2	0.53	other (other)	FW0622	Verrucosispora sp. FIM060022

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.3	0.69	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0001478.5	0.66	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.3	0.64	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2	0.61	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001453.5	0.60	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0000244.4	0.60	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0000940.5	0.60	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0002620.2	0.57	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002690.2	0.53	other (other)	FW0622	Verrucosispora sp. FIM060022

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 30.88 out of 36.53

Confidence: medium

Additional weak hits (23):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.11 out of 26.33

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.07 out of 33.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.42 out of 26.12

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.36 out of 27.78

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.33 out of 36.54

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.37 out of 26.85

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.37 out of 36.54

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.10 out of 25.88

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.38 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.83 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.92 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.02 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.49 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.25 out of 30.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.81 out of 29.65

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.88 out of 28.19

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.76 out of 35.63

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.65 out of 29.65

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.16 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor

NZ_CP095274.1 - Region 10 - azole-containing-RiPP

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Location: 3,124,460 - 3,146,749 nt. (total: 22,290 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MU580_RS14740: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Hydrolases: hydrolase

MU580_RS14745: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Translocases: transporter

MU580_RS14765: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002144.3	0.47	ribosomal	phazolicin	Rhizobium sp. Pop5
BGC0002013.4	0.47	ribosomal	curacozole	Streptomyces curacoi
BGC0000569.5	0.42	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0000571.3	0.41	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000845.5	0.40	other (non-nrp beta-lactam)	clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0000515.4	0.39	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0002346.3	0.39	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0001928.2	0.39	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000188.5	0.39	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000537.3	0.39	ribosomal	nisin U	Streptococcus uberis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002144.3	0.47	ribosomal	phazolicin	Rhizobium sp. Pop5
BGC0002013.4	0.47	ribosomal	curacozole	Streptomyces curacoi
BGC0000569.5	0.42	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0000571.3	0.41	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000845.5	0.40	other (non-nrp beta-lactam)	clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0000515.4	0.39	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0002346.3	0.39	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0001928.2	0.39	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000188.5	0.39	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000537.3	0.39	ribosomal	nisin U	Streptococcus uberis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

Additional weak hits (4):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 18.77 out of 33.73

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.66 out of 28.19

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.15 out of 32.93

Confidence: weak

(Thi)azol(in)e containing peptide predictions

(Thi)azol(in)e containing peptide(s)

MU580_RS14730

Leader:

MSLLMEPTRTTAPEVAPAAGGEAASDALLAEAFGFTITHRGAEEELVMGDVTLCCS

Core:

TTCSSSGSGHQQPR

Core with dehydrations:

DhbDhbCysDhaDhaDhaGDhaGHQQPR

antiSMASH-DB 4.0 matches for MU580_RS14730

23.1%

NZ_CP012109.1:

Lanthipeptides: allorf_4705695_4705880_lanthipeptide

3

CSSSGSGHQQPR

14

CS +G G + PR

3

CSDAGGGVRTPR

14

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Types:

Type I: Featuring genes encoding indolic acid side ring (series e)
Type II: Featuring the gene coding for quinaldic acid moiety formation (series a, b, and c)
Type III: No genes for synthesizing L-Trp derivatives (series d)

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production

Core peptide predictions

MU580_RS14730

Putative Type III

Cleavage pHMM score: 6.10

RODEO score: 30

Monoisotopic mass: 1431.6 Da

Molecular weight: 1432.5 Da

Predicted peptide features:
Central ring: pyridine trisubstituted

Alternative weights: (assuming N unmodified Ser/Thr residues); 1450.5 Da N = 1; 1468.5 Da N = 2; 1486.5 Da N = 3; 1504.6 Da N = 4; 1522.6 Da N = 5; 1540.6 Da N = 6

NZ_CP095274.1 - Region 11 - terpene

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Location: 3,229,127 - 3,253,548 nt. (total: 24,422 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MU580_RS15290: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

MU580_RS15320: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase

MU580_RS15335: isochorismatase

smcogs: SMCOG1027: isochorismatase

Ligases: synthetase

MU580_RS15295: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Translocases: transport

MU580_RS15315: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000644.3	0.63	terpene	carotenoid	Dietzia sp. CQ4
BGC0000637.3	0.58	terpene	carotenoid	Corynebacterium glutamicum
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000648.3	0.56	terpene	carotenoid	Myxococcus xanthus
BGC0000650.3	0.51	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000636.3	0.48	terpene	carotenoid	Brevibacterium linens
BGC0000664.5	0.48	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002309.2	0.46	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000649.3	0.46	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000642.3	0.46	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000644.3	0.63	terpene	carotenoid	Dietzia sp. CQ4
BGC0000637.3	0.58	terpene	carotenoid	Corynebacterium glutamicum
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000648.3	0.56	terpene	carotenoid	Myxococcus xanthus
BGC0000650.3	0.51	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000636.3	0.48	terpene	carotenoid	Brevibacterium linens
BGC0000664.5	0.48	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002309.2	0.46	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000649.3	0.46	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000642.3	0.46	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

MU580_RS15280: Lycopene_cycl

Domain 1 (1 - 107): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

MU580_RS15285: Lycopene_cycl

Domain 1 (4 - 92): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

MU580_RS15290: PT_phytoene_like

Domain 1 (33 - 301): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

MU580_RS15295: PT_FPPS_like

Domain 1 (49 - 332): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (7):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.70 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.48 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.61 out of 29.38

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.03 out of 26.33

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 19.95 out of 30.98

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.06 out of 28.19

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.24 out of 20.01

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description