LOCUS       NZ_CP094676            26329 bp    DNA     linear   CON 30-MAY-2024
DEFINITION  Streptomyces sp. CB09030 chromosome, complete genome.
ACCESSION   NZ_CP094676
VERSION     NZ_CP094676.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB09030
  ORGANISM  Streptomyces sp. CB09030
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Genomic of Streptomyces sp. CB09030
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2022) Xiangya International Academy of
            Translational Medicine, Central South University, Changsha, Hunan
            410013, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: Canu v. v1.5; Racon v. v3.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1510.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022827705.1-RS_2024_05_30
            Annotation Date                   :: 05/30/2024 05:11:20
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,205
            CDSs (total)                      :: 7,118
            Genes (coding)                    :: 7,015
            CDSs (with protein)               :: 7,015
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 40 of 103
            Pseudo Genes (incomplete)         :: 75 of 103
            Pseudo Genes (internal stop)      :: 10 of 103
            Pseudo Genes (multiple problems)  :: 21 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:41:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7717071
            Orig. end                         :: 7743400
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094676.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26329
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="37"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26329
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26329
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16329](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16329)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    381..395
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 20.02"
                     /tool="antismash"
     gene            428..946
                     /locus_tag="L6J92_RS33035"
                     /old_locus_tag="L6J92_33035"
     CDS             428..946
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326510.1"
                     /locus_tag="L6J92_RS33035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33035"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_224293955.1"
                     /transl_table=11
                     /translation="MATGHTEVQVRPGSEDDLKALTDLYNHYVRETPITFDTEPFAPEE
                     RRPWLLSHPEDGPYRLRVATDADSQEILGYATSGPYRPKPAYATSVETTVYVAPHAGGR
                     GIGSLLYASLFDALAGEDVHRAYAAVAQPNEASARLHARFGFRPVGTYREVGRKFGRYW
                     DVAWYERRL"
     gene            complement(991..1752)
                     /locus_tag="L6J92_RS33040"
                     /old_locus_tag="L6J92_33040"
     CDS             complement(991..1752)
                     /EC_number="1.13.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051213 - dioxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016825841.1"
                     /locus_tag="L6J92_RS33040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33040"
                     /product="class III extradiol ring-cleavage dioxygenase"
                     /protein_id="WP_037772701.1"
                     /transl_table=11
                     /translation="MPALYLSHGAPPLADDPVWPGELAAWSADLPRPRAILVVSAHWEE
                     APLALGATRTVPLVYDFWGFPEHYYQVRYEAPGAPALAESVRGLLRAPGTPVQDVPDRG
                     LDHGAYVPLVEMYPGADIPVLQVSMPTLDPVRLMEIGRRLAPLRDEGVLIMGSGFFTHN
                     LAALRQGGIPSWSAEFDHWGRSALESGDVDGLLDFARKSPAGRLAHPRTEHFAPLFVAM
                     GAADATGELDRRRSVIDGFWMGLAKRSVQFG"
     gene            1916..2512
                     /locus_tag="L6J92_RS33045"
                     /old_locus_tag="L6J92_33045"
     CDS             1916..2512
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009189131.1"
                     /locus_tag="L6J92_RS33045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33045"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_224296731.1"
                     /transl_table=11
                     /translation="MNTAPTPASSAGPEAPAEPPTPATPAAPEAPAAGHAPDEPRWLTA
                     GEQFVWRSYIEAATLLEDHLDRQLQRDAGMPHVYYGLLVKLAESPRRRLRMTELAKYAK
                     ITRSRLSHAVARLEKNGWVRREDCPSDKRGQFAILTEEGYEVLRRTAPGHVNAVRQAVF
                     DRLTPQQQESLGEIMRIVAEGLQPSEAGADLPWLR"
     gene            complement(2625..4169)
                     /locus_tag="L6J92_RS33050"
                     /old_locus_tag="L6J92_33050"
     CDS             complement(2625..4169)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388796.1"
                     /locus_tag="L6J92_RS33050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33050"
                     /product="MFS transporter"
                     /protein_id="WP_031044493.1"
                     /transl_table=11
                     /translation="MSQSAVKASGVSDAPDAGRWKALVFIALAQLMVVLDATIVNIALP
                     SAQQDLGISDGNRQWVVTAYALAFGGLLLFGGRIADLWGRKRTFVTGLAGFAVASALGG
                     AATNEAMMFGSRALQGVFGALLAPAALSLLAVMFTDAKERAKAFGIYGAIAGGGGAVGL
                     ILGGFLTEYLNWRWTFFVNIPFAVIAAAGAYLVIREPKGSRNRSPLDIPGVVLSTLGLV
                     ALVYGFTRAESNGWSDATTVGMFVGAAVLLLSFVFVEARVKAPLLPLRVITERNRGGIY
                     LSLGLAVIAMFGLFLFLTYYLQVVKGYTPVKTGFAFLPMIAGMITGSTQIGARLMTRVA
                     PRLLMGPGFLVAAAGMLFLTQLEINTSYAGVLLPGMLLLGLGMGTAFMPAMSMATMGVE
                     PRDAGVASAMVNTSQQVGGAIGTALLNTIAASATTSYIADHMGGASSRSQQQLVQLQGQ
                     VQGYTSAIWFAVGILVVAAAIALTFVNAGRPGGPAVSGSGAGDAAEDELPIPVVAH"
     misc_feature    4324..4339
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.35"
                     /tool="antismash"
     gene            complement(4361..5014)
                     /locus_tag="L6J92_RS33055"
                     /old_locus_tag="L6J92_33055"
     CDS             complement(4361..5014)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388795.1"
                     /locus_tag="L6J92_RS33055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33055"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_243782746.1"
                     /transl_table=11
                     /translation="MQTAIPDQRKVARPRADALRNRERIVTAAREMFVEHGPDVPLDDV
                     ARRAGVGNATVYRNFPDRDALVREVVCSVMDRTARAAELALAETGDAFEALERFVHASA
                     DERISALCPMVSSTFDQFHPDLEAARERVERLVAEVMDRAKVAGQLRGDVGVSDLMIAA
                     AQLSRPPAGTGCLSADRFVHRHLQLLLDGLRAPARTALPGTQVTMEDLRRPCDQ"
     misc_feature    complement(5078..5093)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.69"
                     /tool="antismash"
     misc_feature    5211..5226
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            5409..6695
                     /locus_tag="L6J92_RS33060"
                     /old_locus_tag="L6J92_33060"
     CDS             5409..6695
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975609.1"
                     /locus_tag="L6J92_RS33060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33060"
                     /product="M6 family metalloprotease domain-containing
                     protein"
                     /protein_id="WP_224349947.1"
                     /transl_table=11
                     /translation="MQPQPPSRRIRPRRLAAIGTVTALTLALSTSAGTGRLAPGTSTAG
                     PGPAALSRSSAHGPCMISGGSEIQMSEGVPTSAGYARSTGTVRALTLMIDFSDAPGEGK
                     ALDRYAEFFPQTAKWFRTSSYGRLDYRPETPIRSWLRMPKSFAEYGIERGAPFEPGYRK
                     MVQDMVAAADAKVDFREYDLVNVLVTPNAGPSALDTVLSVTFAGNKEAPVADGVPVANA
                     SFVYSRQDDGSGSYGETGYRVLPHENGHVFGLPDLYTQEGGGAAGHWDIMSEDWGANND
                     LLGWHKWKLGWLDPSQVHCASAPGATEYTLTPLARKGGDKLVVVPLNGRTGYAIELRTR
                     EGNDEAVCRPGVLIYRVDADVDTGMGPVRVYDSQRDSGGCTRSANVHAELSDAAFRPGE
                     TFKDPRRGITIAVSATDGNGEQRVRITRR"
     gene            6801..8471
                     /locus_tag="L6J92_RS33065"
                     /old_locus_tag="L6J92_33065"
     CDS             6801..8471
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007382694.1"
                     /locus_tag="L6J92_RS33065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33065"
                     /product="IclR family transcriptional regulator C-terminal
                     domain-containing protein"
                     /protein_id="WP_243782747.1"
                     /transl_table=11
                     /translation="MTAKPTNEPAPDRTALNSAVPESARPESVAPESVAPEASVPNEAV
                     GPLLRGITVLRRLTEADGVTLSLSGLEKATGLARSTVDRVTATLARMGYVRLDGRDVTL
                     APRLMELGNAYLAALRLPALLSSRADALADELDESVSLAVGDRDGIRFIHQATRRRAMS
                     LSFRIGDRLPAERTAPGPLFATEWTPADWHRWHTRRAGDPQDATFPAVPPRDPATPDPA
                     PSFEHRTTQAATEGWCVDDQLIEPGLVAVSVPVRDPGTGRLACVASVVSHTSRHTAPDL
                     RAALLPRLREAVTTMENDLRAAPPPAPGQPRTDLATWTSASKQELGREFVESLARGLTV
                     LTAFGEGRSRLTLTEVARATGLTRATARRALITHTHAGLITASRDHTFSLTPRVLSLGF
                     PPLSRASLPDIAQPHLTALAARVGESTALAVLSDSGEEIQYTARAAAGRVLTAHVPVGT
                     RLPAHATALGRVLLPHPEARTQGYALVDEELEAGLRAIAAPVRDRTGTVVAAVNVAMHT
                     ARRTREACESDILPELLHTTSHIEADLRVAGRFILIPPT"
     tRNA            8554..8626
                     /anticodon=(pos:7725658..7725660,aa:Arg,seq:cct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="L6J92_RS33070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="L6J92_33070"
                     /product="tRNA-Arg"
     gene            8554..8626
                     /locus_tag="L6J92_RS33070"
                     /old_locus_tag="L6J92_33070"
     gene            complement(8762..9913)
                     /locus_tag="L6J92_RS33075"
                     /old_locus_tag="L6J92_33075"
     CDS             complement(8762..9913)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982953.1"
                     /locus_tag="L6J92_RS33075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33075"
                     /product="hypothetical protein"
                     /protein_id="WP_243782748.1"
                     /transl_table=11
                     /translation="MDPHGPTAQRFPLVARFRPACLPLPERVRSLVYLADAAVNKTDQG
                     LASAVYNQAALIASDLGLPDLAREMCHQHATAYLHACPLPGMSAIRGLEPVVNLARLQI
                     RAGRADEGRQRLLDLYKAVEAGTAARFEGVNVPADLTTTDEDRQEVRAWLWRVLLADGT
                     RTLTTEGRWAEALAHIKAHHGIGKRMLDGRQVAVLAALAAGDTAWAAVLLADTMPGDPW
                     EQAITACLTVLCRRDAGQPIDGHLANLVTAYLARKTEPGMTVFDTRLGLTVLNAIGPAG
                     TLAAHRIVEHLHRRTTDAEDGYAARENLAHPLFTEIATDRQVQDCRTLVRACSLGAGIL
                     PDELRGELTAALSVSGRVIQGSLADSSLGPVHRERSRPGAPAG"
     gene            complement(10001..12082)
                     /gene="fxlM"
                     /locus_tag="L6J92_RS33080"
                     /old_locus_tag="L6J92_33080"
     CDS             complement(10001..12082)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543781.1"
                     /locus_tag="L6J92_RS33080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33080"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_243782749.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.6e-25, bitscore:
                     86.6, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 4.7e-46, bitscore: 155.9,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPDHWQQHNITFVDREIAQRAIAERLGPALIEAEADGQLIGWWF
                     MNKQPWPLRYLADKPSPAIGSLLSDLIGDGVAVSCLPGVYEPETDAFGGPEAIDAAHEL
                     FHSDSRHLLTYQPNPTRFGRRETAVLLASVMMRGAGLDWFEQGDVWAKVAALRPATNPP
                     HPERAAGLAPPMRKLMTADAHSLCRLGGPLHAHEEWVTAFERAGATLADLADRGALTRG
                     LRAVIAHHVIFHANRAGLLRDDQSALSHIAREAVMGTSDHTASPTEATADIDSVSAVNT
                     DTITTPTADAERLRNVLVDQLRADGHARTPAVETALRTVPRHVFVPEASVEDAYANAPV
                     HIKYDTDGTSISCASQPGVVALMLDQLDAQPGERILELGAGTGYNAGLLAHLVGENGHV
                     TTLDVDDDLVEGARTHLAAAGITNVEAVTRDGALGYAEAAPYDRIIATVGAHGVPHAWL
                     QQLAPGGRLLVPQRLKGTVSRSIAYEQHDGRWVSLGSEMNTFMPLRRGIADDDRRVIPL
                     STDGAVRLQAPAGLSIDADALAGVLDQPRTEEWTGMTVRGMESPEWMELFVTCSLPSGL
                     IRMLFCQSAKGTLLTEDPYPSSTAVVDKGAVTYLARRRSKRKTPEGDKLWEFGVIGHGP
                     GSDELAAKVADAIRTWDRDYRDREATFEIQPLDAPEIEQRPGLFALNTPLNRIVVDWR"
     misc_feature    complement(12038..12052)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            complement(12104..13378)
                     /locus_tag="L6J92_RS33085"
                     /old_locus_tag="L6J92_33085"
     CDS             complement(12104..13378)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543780.1"
                     /locus_tag="L6J92_RS33085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33085"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_243782750.1"
                     /sec_met_domain="LANC_like (E-value: 1.1e-40, bitscore:
                     138.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVHPVLGLVDAIAAQLADPDTVPLGSRTLSSDRQHLAYGPPGIA
                     LLHIERAASGLGPWHHAHAWLAAACRQPLTSGPDSHPFYGAPAFAHAVTCAADHLPGSY
                     QRALDALDGQIAVNVGRRLDAAHRRIDAGRLPQLAEFDAIRGLTGYGAYLLRRNPGSST
                     MRAVLDYCVRLTEPITHHGEPLPGWWTETGPSGSPDDRFPGGHANTGMAHGIGGVLALL
                     ALAARNGSVTDGHHAALHTILTWLDRWKEKADGGPVWPYWVTRGELRRARLAPSAPGRP
                     SWCYGTAGLARAQQLAALALGDTRRQIDAENALVAALTGPEQLKATTDNGLCHGFAGLA
                     HTAARTADDAHPSTAGNLRAAILALLAAVTPPDTDPELTAMALIQDEEGGPGLLDGAAG
                     IALALLAPSTAAPPRSAWDACLLIA"
     gene            complement(13375..16329)
                     /locus_tag="L6J92_RS33090"
                     /old_locus_tag="L6J92_33090"
     CDS             complement(13375..16329)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543779.1"
                     /locus_tag="L6J92_RS33090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33090"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_243782751.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.9e-197,
                     bitscore: 655.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 9e-19,
                     bitscore: 66.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.9e-19, bitscore:
                     66.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAWLRAAWADKDVAEALRYSSPVLAAQVGALCTAEHPVLRDVQRA
                     ALPVARYLLRAQHRATPFGLFAGVATAEFGPQARADWSEEHVTVGRAGAEWLAALVARL
                     ESCPDLLERLPVVINNTVTYRGDRLIVPFQPDAQDDRTRAVEASLALTGPVRAVLAATG
                     VPIRFGTLVDKLQAEFPEAGPAKARQLLAELIRRRVLITGLHAPSKETDALGYLVGQLD
                     AVDAGSLAPVAETVRELHAIRAGLEECATHGGRDSVAARMRDLVPGLRRHPVALDLRLD
                     ARLVLPEAVAREIERAALVLTRLSIRPYGTAAWKEYHQRFYERYGIGTMVPLAEVVADS
                     GTGYPDGYPGAPVGARRPRVSARDDALVRMAQAAALDGRDEVILTDEQIESLDVGPDEP
                     RLPPHLEIGVRVHAASLEELQRGRFRLEVMSVPRGAGVSTGRFLSVLTPADRDALVAEL
                     ADLPAADGNTVPAQLSFPPLLPESAHVTRAPQVLPTVISLQEHRVPQDTVLTPEDLAVG
                     CDGRRMYLAVPERGHRVEVVGMHALNLRTHTPPLVRFLTELSRAQCAQVTVFDWGAATA
                     MPFLPRLRYGRTVLAPARWRLEASELPGHARPRAEWDAALSDWRARRRLPRRVHLVEDD
                     RRLFLDLDETGHRALLRRHLNRTRLAVLVEAPEPDAYGWCGGRAHEVVVPLKATRPPTW
                     PPLPAPSRARALSADQMQTPASSSVLLAALYGDPRRQGFLLSRHLPGLLEQLGNPPWWF
                     IRFRDPDQHLRVRIALPDPEAFADTARTVSAWADELRSIGLLADLRYPTSYREMGRWGA
                     GAAWEAAEEVFRADSRAILAQLAQPQRPGLRGLVVAHTVAIASAFLGSTAAGMRWLIDH
                     IPPTAPAPVPRPQFTDAVRLADPSDDWAGLRRVPGGDAIVSGWGDRDTALAAYRPHLPG
                     PDTQGIAVDDVLTSLLHVHFVRHVAVNFPEEEVCLYLARAAALAWTARTRGRAS"
     aSDomain        complement(15709..15984)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_L6J92_RS33090_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.50E-21"
                     /identifier="RREFam001.1"
                     /label="L6J92_RS33090"
                     /locus_tag="L6J92_RS33090"
                     /protein_end="207"
                     /protein_start="115"
                     /score="66.7"
                     /tool="antismash"
                     /translation="VVINNTVTYRGDRLIVPFQPDAQDDRTRAVEASLALTGPVRAVLA
                     ATGVPIRFGTLVDKLQAEFPEAGPAKARQLLAELIRRRVLITGLHAP"
     gene            complement(16547..16726)
                     /locus_tag="L6J92_RS33095"
                     /old_locus_tag="L6J92_33095"
     CDS             complement(16547..16726)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016825826.1"
                     /locus_tag="L6J92_RS33095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33095"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_016825826.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 5e-13, bitscore:
                     47.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRSTVVPSRTEVRPQIPGASDGFDLDVSLVEIADPAGLVNLTDD
                     NCGSTCGACTTNVA"
     gene            complement(16913..17101)
                     /locus_tag="L6J92_RS33100"
                     /old_locus_tag="L6J92_33100"
     CDS             complement(16913..17101)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337811.1"
                     /locus_tag="L6J92_RS33100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33100"
                     /product="hypothetical protein"
                     /protein_id="WP_243782752.1"
                     /transl_table=11
                     /translation="MEWPWITGDCWLGCGRTGVLVIWLGPVQWDGQHAPFDACEPCLDR
                     LQAQALAYFMERRPASA"
     gene            complement(17328..17774)
                     /locus_tag="L6J92_RS33105"
                     /old_locus_tag="L6J92_33105"
     CDS             complement(17328..17774)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004000003.1"
                     /locus_tag="L6J92_RS33105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33105"
                     /product="ATP-binding protein"
                     /protein_id="WP_243782753.1"
                     /transl_table=11
                     /translation="MTSLRKPVEVPSVGHPTYSQTFPCEPSTAEIGRDLVRAVLGVWHI
                     DGLADRAALIVTELIANAARHTPCPEIRLTVGRPSATRVRVGVVDREPTRLPILGQAGD
                     DDESGRGLLLVDAVADRWGYDLHGSGRRPWGKEVWAELSTGGGE"
     gene            18014..19300
                     /locus_tag="L6J92_RS33110"
                     /old_locus_tag="L6J92_33110"
     CDS             18014..19300
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004000004.1"
                     /locus_tag="L6J92_RS33110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33110"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_243782754.1"
                     /transl_table=11
                     /translation="MDTTRNTVLEAWMTEHGYSSNSLAEAVNRAIERLTGRPGGLDGSS
                     VRAWKAGRVTWPKSAARSALEAVTGLPAVALGFVPRGLPSSTPATPQQEDPDMKRRTLV
                     GSIAAAAAAAAAAPGTASPRRIGMSDVNRLNKRFAEIIASDHRHGGQLGIEQRAAALAD
                     EALNLQNAGSATERVRSNLYASAAAFRSSAMWAAIDGRRYDVAKAHMREAQALAEMSGD
                     QAIKFRIWSHAGTMYRHMGRPADALAANDVARNLHLTRRDPLFASLGLARQGAIHGTAQ
                     DRTGTRRACEQAQDAMLRADPADYRPVWMLAFYDQAELDSLALSAHLALGDYSTAEYHA
                     HRCLSALRPHMIRSRAITTTRLAHAQLAQGAPDAATATAMKVPAEAATQHARVTRMLQE
                     FGAALRATAPGSSTVQTWTEHSAAWRMAA"
     misc_feature    18239..18241
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19297..19836
                     /locus_tag="L6J92_RS33115"
                     /old_locus_tag="L6J92_33115"
     CDS             19297..19836
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337821.1"
                     /locus_tag="L6J92_RS33115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33115"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_243782755.1"
                     /transl_table=11
                     /translation="MTTAPAIELRTFTTLDTARGDLLDVYADVRAPLLHLPNYAVTAFG
                     ERLDRHGAEPGFTAVLAYADGHPVGYAYGNTIEHGDRYWQRTSPTPAEKYTERPAVALK
                     EIGVRPTWRKTGTARRIHDALLTTRNEPYVTLMVNPAAGDGKVHVLYKSWGYGDIGQSQ
                     PSPASPVLTVMIRAIR"
     gene            20191..21371
                     /locus_tag="L6J92_RS33120"
                     /old_locus_tag="L6J92_33120"
     CDS             join(20191..20475,20478..21371)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611786.1"
                     /locus_tag="L6J92_RS33120"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="L6J92_33120"
                     /product="IS3 family transposase"
                     /protein_id="WP_243780900.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MPKPYPKEFREDVVRVARNREPGVTLEQIAADFGVHPITLSKWLR
                     RADTEEGTRPATASGESAELREARKRIRLLEQENEVLRRAAAYLSQANLPKMMYPLVRE
                     LAAAAAPCRVPVAVTCRVLGLARQPYYRWLARPATDAELTEAYRANALFDAHRDDPEYG
                     HRFLLDEARAAGEAMAERTAWRICRDNGWWSAFGKRRGRGKNAKAGPPVHDDLVRRNFT
                     ADGPNRLWLTDITEHATGEGKLYLCAVKDAFSGRIVGYSIDARMQSRLAVRALESAVAR
                     RGPVAGCIVHSDRGSQFRSRKVAAVLTRHGLVGSMGRVGAAGDNAAMESFFALLQKNVL
                     DRRTWVTRQELRIAIVTWIERTYHRRRRQRRLGRLTPVEYETIMTPPAALAA"
     gene            21498..21902
                     /locus_tag="L6J92_RS33125"
                     /old_locus_tag="L6J92_33125"
     CDS             21498..21902
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021594.4"
                     /locus_tag="L6J92_RS33125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_33125"
                     /product="DUF2326 domain-containing protein"
                     /protein_id="WP_279575313.1"
                     /transl_table=11
                     /translation="MYGSGRQAYLEFDAGPSSLRIVPHVDSDDSRGIGNMVIFCFDLTM
                     AVVAHRHGRGPNFLVHDSHLFDGVDDRQLRDALELAAEVTEREGMQYVVTLNSDDLEKA
                     QRKGYDASGRVLPVRLDDEYDDGGLFGFRF"
     gene            complement(22019..22474)
                     /locus_tag="L6J92_RS33130"
                     /old_locus_tag="L6J92_33130"
     CDS             complement(22019..22474)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L6J92_RS33130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L6J92_33130"
                     /product="hypothetical protein"
                     /protein_id="WP_243782756.1"
                     /transl_table=11
                     /translation="MALGRMIREAAQLEFRLELTARILCESHYGELLILAESSSRTIKV
                     CHVLVDAHEELTAHAREDLKGMLRESNELFTERHRYVHGAAMFGGDDGPVTMRTRRLKM
                     GLEIAPLVQKDVASLADRFAALTSGITAWITDLINGRLRDGADPVTE"
     misc_feature    complement(22488..22503)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     gene            complement(22703..26071)
                     /locus_tag="L6J92_RS33135"
                     /old_locus_tag="L6J92_33135"
     CDS             complement(22703..26071)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L6J92_RS33135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L6J92_33135"
                     /product="hypothetical protein"
                     /protein_id="WP_243782757.1"
                     /transl_table=11
                     /translation="MTDGDTNAHFLCLGPLPTDEVARQAVSAAVLDDVVRLHAAGRRLT
                     GIFVLGTVGVRMPAEELVFEVQLACVDLGYEPFVVPIPGPADLRLPATRLLARSLTEDW
                     ARTAPELWAGELTEDIVAPLETKVLSDITAWHADTARAIEGWHRGLLPGDGSLSVEVGG
                     RTLGLVSVNTVFRMVAEDAAPGLAGCFREQLDLAVGGDFAAWAEGNALTLVAAGQSGAW
                     PELPSETAPLVKLAGSGESSAGWVLPAGDAVRHRLLRTQFGDRRVVVKDAGDGQTISTA
                     VRPGSAVRGPQLRVVQPAEEPYDEKPLLDAFHQNLSTGRMALVLVSGPEAGPPIGLDEL
                     NHQLAEAVFGAVPSPSAPPLRETWAAAQSQLTGEQRAQYLSELCVPDGEVPANVHRLMR
                     APWSRIYDFTGSDLLKLARAADTTDRISLVNACEEPPTDKREVLEVVAMHGLPQEEISQ
                     NFGDAEDESPRHARRQWLRRFRAELLERPVLFVALSPNSPALWDTLRMAGRLSGEYEFP
                     GFLVAPEGTATDRARLRQTRLQHIRTAPSDFVSRQLAPGNQSLVLGKRLLTQEHAGALR
                     DVGVQRVAQLVQDTPPGYASFLEGRDPTWGDIKDRKISAQLSLIDAIATRTQPSAEGRM
                     PVVLVKGSAGSGKTTALMQLAYKLHRKSSHVGWVDRAANLTSGAVAAQARQQNLDAIFV
                     DDVNIFTRSASDLMHSLNDGGKRLVVAAIRVTRQSEIPEGFPAEVVDFDCPLTDGDLKN
                     LVKALQKNALIGDLKKYRPMQAKVDRLRDLSEKGLLAAMIEAVTGSTLREKVVSEYEDL
                     SKYGQVYQWAYAAVCIVNSDDIFRQIGISSTGLLEVISYPDPPDRSHREAIKGLQEMGL
                     LVAMSGGLLRCRQRTIADTVVHTVLTKRLKELETVMTKLLVSYAERACHSEDDQHPDRR
                     AMIRLLSHNVMREFGLPPEAARRTYHAAHELLQDDRHYWLQRAEFEIDQGRFDLARNYL
                     AAGRACRYGQDDRLLRTADARVRLRDSVAHPNDVRRLQDAVDAVQELHDVVRGPEGRKA
                     PHAFVALARDGASWLLQCGQALGHQQYVDLLEQVTDDVSYGKVCCAGRNEVKAAAAVFD
                     GKRGRLQDRVPGFPI"
ORIGIN
        1 gccgcgcgaa cacaccggcc tcgatggtct gggacagctc gacctccttg gcggcgtcga
       61 gcaggggtgt gcgggcgatc tcgtcgaggt acatgccgac cagatcgcgg tcggcgagct
      121 ctccgccgtt ggcgcggacg ctggttgccg cgccggaggt ctcgccggtg gcggacttac
      181 gacgggcgac ggcacgggtt gccatgcgtg ctcccttgcg atggtggttc agcgggtggt
      241 ccttcggacg tccggacgcc gtacggtgtg tcccagcggc cggatttcgc ctccagcccc
      301 tgacgggact ctcctcgggt gccctgcatc cgatggaaac aacgactgga aaccggacag
      361 aattcccaac ccgtccctcg atttttctga tcatgcagta ccctgtgccg ccacacgagg
      421 aggcgggatg gcgacggggc acacggaggt ccaggtcaga ccggggagcg aggacgatct
      481 caaggccctc accgacctct acaaccacta cgtgcgtgag acgcccatca ccttcgacac
      541 cgagcccttc gctcccgagg agcgccgccc ttggctgctc tcccatcctg aagacggccc
      601 gtaccgcctg agggttgcga cggacgcgga ctcacaggag attctgggct acgccacctc
      661 cggcccctac cgaccgaagc ccgcctacgc gacctcggtg gagaccaccg tctacgtcgc
      721 cccgcacgcc ggcggccgcg gcatcggctc cctgctctac gcgtccctct tcgacgccct
      781 ggccggcgag gacgtgcacc gcgcctacgc ggccgtcgcc cagccgaacg aggcctcggc
      841 ccggctgcac gcccgcttcg gcttccggcc cgtgggcacg taccgcgagg tgggccgcaa
      901 gttcggccgc tactgggacg tggcctggta cgagcggcgc ctgtagcccg ccccggccgc
      961 ggcccacccc gacggatccc ttccagcccc tcagccgaac tgcaccgacc tcttggccag
     1021 gcccatccag aacccgtcga tcacggaccg gcgccggtcc agctcaccgg tggcgtccgc
     1081 cgcgcccatc gccacgaaca gcggcgcgaa gtgctccgtg cgcgggtggg cgagccgtcc
     1141 cgccggggac ttgcgggcga agtcgagcag cccgtccacg tcgccggact ccagcgcgga
     1201 ccggccccag tggtcgaact ccgcggacca cgaggggatg ccgccctggc gcagcgcggc
     1261 caggttgtgg gtgaagaagc cggagcccat gatcagtacg ccctcgtcgc gcagcggcgc
     1321 gagcctgcgg ccgatctcca tgagccgcac cgggtcgagg gtcggcatgg agacctggag
     1381 gaccggtatg tcggcgccgg ggtacatctc gaccagcggg acgtaggcgc cgtggtccag
     1441 gccgcggtcg gggacgtcct gcaccggcgt gccgggggcg cgcagcagcc cgcgcacgga
     1501 ctcggcgagc gcgggggcgc cgggggcctc gtaccgcacc tggtagtagt gctccgggaa
     1561 gccccagaag tcgtagacga gagggacggt acgggtggca ccgagcgcga gcggagcctc
     1621 ctcccagtgg gcggagacga cgaggatcgc cctggggcgg ggcaggtcgg cggaccaggc
     1681 ggcgagttca ccgggccaga cggggtcgtc ggcgagcggc ggcgcgccgt gactgaggta
     1741 gagggcgggc atgcggtcct gcgtggcggc ggccatggcg cgactcccaa tccggtacgt
     1801 gacccagcac atgaaccagt acttcaacca gtacttgaac tctcaatctt tacttgccaa
     1861 caatctacgc ctaagttgtt caacattcaa ggagtcgtct cttacagtgg gatacatgaa
     1921 cacggcaccc accccggcgt cctccgccgg gcccgaagcg cccgccgagc cccccacgcc
     1981 cgccacaccg gccgcccccg aagcccccgc cgcaggccac gcacccgacg agccccgctg
     2041 gctcaccgcc ggggagcagt tcgtgtggcg ctcctacatc gaggccgcca ccctcctgga
     2101 ggaccacctc gaccggcagc tccagcgcga cgcgggcatg ccgcacgtct actacggcct
     2161 gctggtcaaa ctggccgagt caccgcgccg gcggctgcgg atgacggagc tggccaagta
     2221 cgcgaagatc acccgctccc ggctctcgca cgcggtcgcc cgcctggaga agaacggctg
     2281 ggtacgccgc gaggactgcc cctccgacaa gcgcggccag ttcgccatcc tcaccgagga
     2341 ggggtacgag gtgctgcgcc ggaccgcgcc ggggcacgtg aacgccgtac gccaggcggt
     2401 cttcgaccgg ctcaccccgc aacagcagga gtccctcggc gagatcatgc ggatcgtcgc
     2461 cgagggactc cagcccagcg aagcgggcgc ggacctgccc tggctgcgct gagcgcgcag
     2521 ccggggcagg tcctgggaac cgtgcgcggg ggcgtcccct cccccttgcg cacgggtgga
     2581 tcagagggcc cgaaaggccc gagcgggtac cgcgtccggt gtcgtcagtg ggcgacgacc
     2641 gggatcggca gctcgtcctc ggccgcgtcg cccgcaccgg agccgctgac cgcggggccg
     2701 ccggggcggc cggcgttgac gaaggtcagg gcgatcgcgg ccgccacgac caggatgccg
     2761 acggcgaacc agatggcgct ggtgtagccc tgcacctggc cctgcagctg caccagctgc
     2821 tgctgggagc gggaggacgc gccgcccatg tggtcggcga tgtacgaggt ggtcgccgag
     2881 gcggcgatcg tgttcagcag tgccgtaccg atcgcgccgc ccacctgctg cgaggtgttg
     2941 accatcgccg aggcgacacc ggcgtcccgc ggctccacgc ccatggtggc catggacatc
     3001 gccggcatga acgccgtacc catgccgagg ccgagcagga gcatgccggg cagcagcaca
     3061 ccggcgtagg aggtgttgat ctccagctgg gtgaggaaca gcatgccggc ggcggcgacc
     3121 aggaagccgg ggcccatcag cagccggggc gcgacccggg tcatcagccg ggcgccgatc
     3181 tgggtggagc ccgtgatcat gcccgcgatc atcggcagga aggcgaagcc ggtcttgacc
     3241 ggcgtgtagc ccttcacgac ctgcaggtag taggtcagga agaggaacag gccgaacatc
     3301 gcgatgacgg ccaggcccag cgagaggtag atcccgccgc ggttgcgctc ggtgatgacg
     3361 cgcagcggca gcagcggggc cttgacccgg gcctcgacga acacgaagga caggagcagc
     3421 acggcggcgc cgacgaacat gccgaccgtc gtggcgtcgc tccagccgtt ggactcggca
     3481 cgggtgaagc cgtacacgag cgcgaccaga ccgagggtgg acaggaccac gccggggatg
     3541 tcgagcggcg agcggttgcg gctgcccttc ggctcacgga tgaccaggta cgcaccggcc
     3601 gcggcgatga cggcgaacgg gatgttcacg aagaacgtcc agcgccagtt caggtactcg
     3661 gtgaggaacc cgccgaggat cagacccacg gcaccgccgc caccggcgat cgcgccgtag
     3721 atgccgaagg ccttggcgcg ctccttggcg tcggtgaaca tcacggcgag cagggagagc
     3781 gcggcgggcg cgagcagcgc gccgaagacg ccctggaggg cgcgggagcc gaacatcatc
     3841 gcctcgttgg tggccgcgcc gccgagcgcc gaggccacgg cgaagccggc caggccggtg
     3901 acgaaggtgc gcttgcggcc ccacaggtcg gctatccgac cgccgaacag cagcagaccg
     3961 ccgaaggcga gggcgtaggc cgtgacgacc cactgccggt tgccgtcgga gatgccgagg
     4021 tcctgctggg cggagggcag ggcgatgttc acgatggtgg cgtcgaggac caccatcagc
     4081 tgggcgagcg cgatgaagac gagcgctttc cagcgtccgg cgtccggggc gtcggagacg
     4141 ccggacgcct tgacggctga ctgagacatg gggataccca cttcgggact tcgtgacgga
     4201 aaaaggtgag taaagggacg agcggaccgc ggcgaggccg cgaccgtccc ggacgacgac
     4261 cggaaggcca ccgtccagag ctagggacta ctgggctact ggactgctcc agagctacgg
     4321 gctactggac tactccagag cgctacggag tactggacta ctactggtcg cagggccggc
     4381 gcaggtcctc catggtgact tgcgtgcccg gcagggcggt gcgggccgga gcccgcaacc
     4441 cgtccaggag cagctgcaga tggcgatgga cgaaccggtc ggcactcagg caccccgtac
     4501 cggccggggg ccggctgagc tgggccgcgg cgatcatcag atcgctcacg cccacgtcac
     4561 cacggagctg accggccacc ttcgcccggt ccatgacctc ggcgacgagc cgttcgaccc
     4621 gttcgcgcgc cgcttccagg tccgggtgga actggtcgaa cgtgctggac accatggggc
     4681 acagggcgct gatccgctcg tcggcggagg cgtgcacgaa gcgctccagc gcctcgaacg
     4741 cgtcgccggt ctccgcgagg gccagttcgg ccgcccgtgc cgtgcggtcc atgaccgagc
     4801 agacgacctc gcggacgagg gcgtcgcggt cggggaagtt gcggtacacc gtggcgttgc
     4861 cgacgccggc ccggcgggcg acgtcgtcga gcggcacgtc agggccgtgc tcgacgaaca
     4921 tctcacgggc ggcggtgacg atccgctccc ggttgcgcag ggcgtcggcg cggggcctgg
     4981 ccaccttgcg ctggtcgggg atcgcggtct gcacggcgta ctccttcggt ctgtgagggt
     5041 gtttctcttc ttgattggtc ttgctggtct cgaccgagct ggtctcgacc ggtcttgctg
     5101 gtcttgctgg tcttgactgg cgatccgggg accccgtccc cgtttcgctc ggacacaggt
     5161 ctaaacgggc agacggtccc cggttatttc ccgctcccga agaactttcc ggtgacctgg
     5221 ctcacaccgc cctcggctgc tccctcctca cggtcggtga ggggtcggac cctctcaccc
     5281 gatcggcggc taccggtggg aaacccacga tcggccgccc cagcgcgcgc ccgcgcaccc
     5341 cccggcacag ggtgaggcca tgggtgcagc cggtgccggg cgggctgccg tggtccgggg
     5401 aggtccgcat gcagccgcag ccgccgagcc gacgcatacg cccgcgccgg ctggccgcga
     5461 tcgggaccgt caccgccctg accctcgcgc tcagcacctc ggcgggcacc ggccgcctcg
     5521 cccccggcac ctcgaccgcg ggcccgggcc ccgccgccct ctcccgctcc tccgcgcacg
     5581 gcccctgcat gatcagcggc ggctccgaga tccagatgtc cgagggcgtg cccacctccg
     5641 ccggttacgc ccgttcgacg ggcaccgtcc gcgccctgac cctgatgatc gacttctccg
     5701 acgcgcccgg cgagggcaag gcgctcgacc ggtacgcgga gttcttcccg cagaccgcga
     5761 agtggttccg caccagcagc tacggccgcc tcgactaccg ccccgagacc ccgatccgca
     5821 gctggctgcg gatgcccaag tcgttcgccg agtacggcat agagcgcggc gcccccttcg
     5881 aacccggcta ccgcaagatg gtccaggaca tggtcgcggc ggccgacgcg aaggtcgact
     5941 tccgcgagta cgacctcgtg aacgtcctgg tcaccccgaa cgccggcccc tccgccctgg
     6001 acacggtcct gtccgtgacc ttcgccggca acaaggaggc ccccgtcgcc gacggcgtcc
     6061 cggtcgccaa cgcctcgttc gtctactccc gccaggacga cggttccggc tcctacggcg
     6121 agaccggcta ccgggtcctc ccccacgaga acggccacgt cttcggcctg ccggacctct
     6181 acacccagga aggcggcggg gcggccggcc actgggacat catgagcgag gactggggcg
     6241 ccaacaacga cctgctcggc tggcacaagt ggaaactggg ctggctcgac ccgtcccagg
     6301 tgcactgcgc gtccgcgccg ggcgcgacgg agtacacgct gactccgctg gcccgcaagg
     6361 gcggcgacaa gctggtggtc gtcccgctga acggcaggac gggttacgcc atcgagctgc
     6421 gcacccgcga gggcaacgac gaggcggtgt gccggccggg ggtgctgatc tacagggtcg
     6481 acgcggacgt ggacaccggc atgggcccgg tccgggtcta cgactcccag cgggacagcg
     6541 gcggctgcac ccgcagcgcg aacgtccacg ccgaactctc cgacgccgcc ttccgtcccg
     6601 gcgagacctt caaggacccg cgccggggca tcacgatcgc ggtgtcggcg acggacggca
     6661 acggcgagca gcgggtgcgg atcacgcgca ggtgagaagg ggcgggcggc aacgcctgcg
     6721 ggccgggacc gccgggacgg ccgacgggct tacggtgggc acgctctgac cgccgtaccg
     6781 gaaagtcgac gaccgccccg atgaccgcca aaccgaccaa cgagcccgca ccggaccgga
     6841 ccgccctgaa ctcagcggta ccggaatcag cgagaccgga atcagtggca ccggaatcag
     6901 tggcacccga agcatcggtg ccgaacgagg cggtcggccc cctcctgcgc ggcatcacgg
     6961 tcttgcgccg cctgaccgag gcggacggcg tcaccctctc cctcagcggc ctcgagaagg
     7021 ccaccggcct ggcccgctcc acggtcgacc gcgtcacggc gaccctggcc cgcatgggct
     7081 acgtccgcct ggacggccgc gatgtgaccc tcgccccccg cctgatggaa ctgggcaacg
     7141 cctacctggc cgccctgcgc ctgcccgccc tgctctcctc ccgcgccgac gccctggccg
     7201 acgaactgga cgagtcggtg tcgctggcgg tcggcgaccg tgacggcatc cgcttcatcc
     7261 accaggccac ccgccgccgc gcgatgtccc tgagcttccg catcggcgac cgcctcccgg
     7321 ccgaacgcac ggcgcccggc ccgctgttcg ccacggagtg gaccccggcc gactggcacc
     7381 gctggcacac ccgcagggca ggcgacccgc aggacgcgac gttccccgcc gtaccacccc
     7441 gcgaccccgc cacccccgat cccgccccct ccttcgaaca ccgcaccaca caggcggcga
     7501 ccgaagggtg gtgcgtggac gaccagttga tcgaaccggg cctggtagcg gtctccgtcc
     7561 ccgtacggga ccccggcacg ggtcggctgg cctgcgtggc gagcgtcgtg agccacacca
     7621 gccgccacac ggcaccggac ctgcgggccg ccctcctccc ccggctgcgc gaggcggtca
     7681 cgacgatgga gaacgacctg cgcgccgccc cgcccccggc accgggacaa ccccgcaccg
     7741 acctggccac ctggacgagc gcgtcgaagc aggaactggg ccgggagttc gtcgagtccc
     7801 tggcccgcgg cctgaccgta ctgaccgcct tcggcgaggg ccgctccagg ctgaccctca
     7861 cggaggtggc gagggccacc ggcctgaccc gcgccacggc ccggcgggca ctgatcaccc
     7921 acacccacgc aggcctgatc accgcgtccc gggaccacac cttctccctc accccccggg
     7981 tcctctccct cggcttcccg cccctctccc gcgcgtccct ccccgacatc gcccagcccc
     8041 acctgaccgc cctggccgcc cgcgtcggcg agtcgacggc gctggccgtc ctctccgact
     8101 cgggcgagga gatccagtac acggcccgag ccgccgcagg ccgcgtcctg accgcccacg
     8161 tcccggtcgg cacccgcctc ccggcccacg cgacggccct gggccgcgtc ctcctgcccc
     8221 accccgaggc ccggacgcag ggctacgccc tggtcgacga ggaactggag gccggcctgc
     8281 gcgcgatcgc cgccccggtt cgcgaccgca cgggcacggt ggtggcggcc gtcaacgtgg
     8341 ccatgcacac ggcccgccgc acgagagagg cctgcgagtc ggacatcctc cccgagctcc
     8401 tccacacgac gtcccacatc gaggccgacc tccgcgtggc aggccgcttc atactgatcc
     8461 ccccgacctg accccaccca ccctccccac caccgatgcc acccctcccc ccgatccgct
     8521 aacctgttgt cacgccgccc acaacggcgc cccgccttcg tagctcaggg gatagagcac
     8581 cgctctccta aagcgggtgt cgcaggttcg aatcctgccg ggggcacaac gcgttaccgc
     8641 tctgacctgg aggttctccc cctcagggag ggctcctact cggcctcgga ctcctcgtcc
     8701 ggggccgttt tcgtgaccgg acggagagtt gatctcccaa atatccccta aaggatcagc
     8761 atcatccagc gggggctccg ggccgggacc gctccctgtg gacgggaccg agagaggaat
     8821 ctgcgaggct tccttgaatc actcggccgc tgacgctcag agccgccgtc agctctcctc
     8881 gtagctcgtc cgggaggatc ccagcgccga gggagcaggc gcgcaccagc gtgcgacagt
     8941 cctgcacttg ccggtccgtg gcgatctcgg tgaacagagg gtgagccaag ttctcgcggg
     9001 ccgcgtagcc gtcttctgcg tccgtcgtcc tgcggtggag gtgctcgacg atgcggtgcg
     9061 cggcgagcgt cccggcggga ccgatcgcgt tgaggactgt gagtccgagc cgggtgtcga
     9121 agacggtcat ccctggttcg gtcttccgtg cgaggtaggc cgtcaccagg ttcgccaggt
     9181 gaccgtcgat gggctgcccg gcgtcgcggc ggcatagaac ggtcaggcat gccgtgatgg
     9241 cttgttccca tgggtcgccg ggcatcgtgt cggcaaggag gacagctgcc cacgcggtgt
     9301 cacccgcggc gagggcagcg agtacggcga cctgtcgacc gtcgagcatc cgtttcccga
     9361 tgccatggtg ggctttgatg tgcgccaggg cctcggccca tcgtccctcg gtggtgaggg
     9421 tgcgtgtgcc gtccgcgagg aggacgcgcc acagccaggc gcgaacctcc tggcggtctt
     9481 catcggtcgt agtgaggtcc gcgggtacgt tgacgccttc gaagcgggcg gctgtgcccg
     9541 cctcgacggc cttgtacagg tcgagcagtc gctgacgccc ctcgtctgcg cggccggcgc
     9601 ggatctggag gcgggccagg ttgacgaccg gttccaaccc tcggatcgcg ctcatgccgg
     9661 ggaggggaca ggcgtggagg tacgcagtgg cgtgctggtg gcacatctcg cgggcgagat
     9721 cgggaaggcc gaggtcggag gcgatgagcg cggcctggtt gtagacagcc gacgcaagcc
     9781 cttggtcggt cttgttcacc gcggcgtcgg ccaggtagac gagactgcgt acacgctcgg
     9841 gcaggggcag gcaggcgggc cggaatcggg cgacgagcgg gaagcgctgg gctgtgggtc
     9901 cgtgcggatc catgggtccc ccagtgtgtg cgtgagggct ggtggggcga cggtgcccgc
     9961 cgcctgcgtg ccgcaggcac cgtccgctac acgtggggcg tcaccgccag tcgacgacga
    10021 tgcggttcag cggggtgttg agggcgaaga gaccggggcg ctgctcgatc tcgggggcgt
    10081 cgaggggctg gatttcgaac gtggcctcac ggtcgcggta gtcgcggtcc catgtgcgaa
    10141 tggcgtcggc gaccttcgcg gccagctcgt cgctgccggg gccgtggccg atgacgccga
    10201 actcccagag cttgtcgccc tcgggagtct tcctcttcga ccggcgccgg gcgaggtagg
    10261 tgacggcacc cttgtcgacg accgcggtcg acgaggggta ggggtcctcg gtgagcagag
    10321 tgcccttggc gctctggcag aacagcatcc ggatcaggcc ggagggcaag gagcaggtaa
    10381 cgaacagttc catccactcc ggtgactcca taccgcggac cgtcatgccg gtccactcct
    10441 cggtgcgcgg ctggtcaagt acgcccgcga gagcatcggc gtcgatgctg agcccggcgg
    10501 gggcctggag tcgtacggca ccgtccgtgc tgagagggat cactcggcgg tcgtcgtcag
    10561 cgatgccccg ccgaagcggc atgaaggtgt tcatctcgct gccgagggag acccaccggc
    10621 cgtcatgctg ctcgtaggca atggagcggg acaccgtgcc cttgagacgc tgggggacga
    10681 gaagccgacc gccgggggca agctgctgca gccaggcgtg cggcacgccg tgcgcgccca
    10741 cggtggcgat gatccggtcg tacggcgctg cttcggcgta gccgagggcc ccgtcgcggg
    10801 tcacggcctc gacgttggtg atcccggcgg cggcgaggtg cgtgcgggca ccctccacga
    10861 ggtcgtcgtc aacgtcgagg gtggtcacgt gtccgttctc accgaccagg tgggcgagca
    10921 gaccggcgtt gtaaccggtg ccggcgccga gttcgaggat gcgctcgcct ggctgggcgt
    10981 cgagctggtc cagcatgagg gcgacgacgc ccggctgcga ggcgcaggag atggacgtgc
    11041 cgtcggtgtc gtacttgatg tgcaccggtg cattggcgta ggcgtcttcg accgatgcct
    11101 cgggcacgaa cacgtggcgg ggcacggtcc gcaacgcggt ctcgacagcg ggcgtgcggg
    11161 cgtgtccgtc cgcacggagc tggtcgacca ggacgttgcg gaggcgctcg gcgtccgccg
    11221 tgggggtggt gatcgtgtcg gtgttcaccg cgctgacgct atcgatgtcg gccgttgcct
    11281 cggtgggcga cgcggtgtgg tcactcgttc ccatgactgc ctctcgtgcg atgtgggaca
    11341 gggcgctctg gtcgtcccgg aggagaccgg cgcggttggc atggaagatc acgtggtggg
    11401 cgatgacggc tcgcagaccg cgggtgaggg cgccgcggtc tgcgaggtcg gcgagcgtgg
    11461 caccagcccg ttcgaaggcg gtcacccatt cctcgtgcgc gtggagtggg ccgcccaggc
    11521 ggcagaggct gtgggcgtcg gcggtcatga gcttccgcat gggcggagcc agtccggcgg
    11581 cccgttcggg gtgtggtgga ttggtggccg ggcgaagggc cgcaaccttc gcccatacgt
    11641 cgccctgttc gaaccagtcg agtccagcgc cgcgcatcat gacgctcgcc agcaggacgg
    11701 cggtctcccg gcgcccgaag cgcgtcgggt tcggctggta ggtgagcagg tggcgggagt
    11761 cgctgtggaa cagttcgtga gccgcgtcta tggcctcggg tccgccgaat gcgtcggtct
    11821 cgggctcgta aacgcctggc aggcacgaca cggccacgcc gtcgccgatg agatcgctca
    11881 ggagcgaccc aatggctggt gagggcttgt ccgcgaggta acgcagcggc cagggctgct
    11941 tgttcatgaa ccaccagccg atgagctgcc cgtcggcctc agcctcgatc agggcggggc
    12001 ctaggcgttc agcgatggcg cgctgggcaa tctcgcggtc gacgaaggtg atgttgtgct
    12061 gctgccagtg gtcgggaggc atagaggtcc ttcggtcggt ggatcaagcg ataaggaggc
    12121 atgcgtccca ggcggaccgg ggcggtgcgg cggtgctggg cgcgaggagg gccagggcta
    12181 tgccggcggc gccgtccagt aggccggggc cgccttcctc gtcctggatg agtgccatgg
    12241 ccgtgagttc ggggtcggtg tccggtggag tgaccgcagc caggagggcc aggatcgcgg
    12301 cgcggagatt tcccgcggtc gaggggtggg cgtcgtcggc cgtacgcgcg gcagtgtggg
    12361 cgagacccgc gaacccgtgg cagaggccgt tgtccgtggt ggccttcagc tgctcgggac
    12421 cggtgagggc ggccacgagc gcgttctccg cgtcgatctg gcgtcgggtg tcgccgaggg
    12481 cgagcgcggc aagttgctgg gcgcgggcga ggccggcggt gccgtagcac caggacggtc
    12541 gcccgggcgc ggacggggcg agacgcgccc tgcgcagctc gccccgagtg acccagtacg
    12601 gccagaccgg cccgccgtcg gccttctcct tccagcggtc cagccaggtc aggatggtgt
    12661 gcagtgccgc gtggtgcccg tcggtcacgg agccgttccg agcggcgagg gccaggagcg
    12721 cgagcacgcc gccgatgccg tgcgccatac cggtgttggc gtgtccgccg ggaaatcggt
    12781 catccgggct gccggaggga ccggtctccg tccaccagcc cggcaggggc tcgccgtggt
    12841 gggtgatcgg ttcggtgagg cgcacgcagt agtcgagaac tgcgcgcatc gtggagctgc
    12901 cggggtttcg gcgcagtagg taggcgccgt atccggtgag gccccggatg gcgtcgaact
    12961 cggcgagctg cggcaggcgt ccggcatcga tgcggcggtg cgcggcatcg agacggcgcc
    13021 cgacgttgac ggcgatctgt ccgtccaacg cgtcgagggc tcgctggtag gagccgggaa
    13081 ggtggtcggc ggcacaggtc acggcgtggg cgaaggcggg cgccccgtag aacgggtggc
    13141 tgtccgggcc gctggtgagc ggctgccgac aggcggcggc gagccaggcg tgggcgtggt
    13201 gccacgggcc gaggccgctc gcggcccgct cgatgtgcag cagcgcgatt ccgggagggc
    13261 cgtaagcaag atgctgccgg tccgaggaca gcgtcctgga gccgaggggc acggtgtcgg
    13321 gatcggcgag ttgggcggcg atggcatcga ccaggccgag cacggggtgg acggtcacga
    13381 agccctcccc ctggtgcggg ctgtccaggc cagggcggcg gcgcgcgcca ggtagaggca
    13441 cacctcttcc tccgggaagt tcacggcgac gtggcgcacg aagtggacgt gcagcaggga
    13501 ggtcaggacg tcgtcgacgg cgatgccctg agtgtccggg ccgggcaggt gcggccggta
    13561 cgcggcgagc gccgtatccc ggtcgcccca tcccgacacg atggcgtccc cgcccgggac
    13621 acggcgcagc cccgcccagt cgtcgctcgg gtcggcgagc cgtacggcat cggtgaactg
    13681 cgggcgagga acgggagcgg gggctgtcgg cgggatgtgg tcgatcagcc accgcatccc
    13741 ggctgcggtg ctgccgagga acgcggaggc gatggcgacc gtgtgggcca ccactagccc
    13801 gcgcagtccg gggcgctgtg gctgcgcgag ttgggccagg atggcgcgcg agtccgcccg
    13861 gaaaacctcc tcggcagcct cccatgcggc gccggcgccc cagcggccca tctcccggta
    13921 ggaggtggga tagcgcaggt cggccagcag gccgatgctt cgtagctcgt cggcccaggc
    13981 gctcaccgtt cgggccgtgt cggcaaaggc ttcggggtcg gggagggcga tgcgtacgcg
    14041 aaggtgttgg tccgggtcgc ggaagcgaat gaaccaccac ggcgggttgc cgagctgttc
    14101 gaggaggccg ggcaagtgcc gggagagcaa gaagccttgg cggcgggggt caccgtacag
    14161 ggcggccaga agaaccgagg aagaggcagg cgtctgcatc tggtccgcag acagggcacg
    14221 agcccggctg ggggctggca gaggtggcca cgtcggcggt cgggtcgcct tgagcggaac
    14281 tacgacctcg tgggctcgcc cgccgcacca gccgtacgca tcaggttccg gggcctcgac
    14341 gagtacggcc aggcgcgtac ggttgaggtg tctgcgcagg agcgcacggt ggccggtctc
    14401 gtcgaggtcg aggaagagac gtcggtcgtc ctctactaga tggacgcggc gcggcagtct
    14461 ccgccgggca cgccagtcgc tgagcgcggc gtcccactca gcccgagggc gggcatggcc
    14521 gggcagttcg gacgcttcca accgccagcg tgccggggcc agcacagtgc ggccgtaccg
    14581 cagacgtgga aggaacggca tcgccgttgc ggcgccccag tcgaagacgg tgacctgcgc
    14641 gcactgggcg cgggacagtt cggtgaggaa ccgcaccagt ggtggggtgt gggtgcgcag
    14701 gttcagcgcg tgcattccaa cgacctccac gcggtggcct cgctcaggga cggcgaggta
    14761 catgcggcgg ccgtcgcacc ccacggccaa gtcctccggg gtgaggacgg tgtcctgcgg
    14821 aacgcggtgc tcctgaaggc tgatcacagt gggcaggacc tgtggggcgc gagtgacgtg
    14881 ggcgctctcg gggagcaaag gcgggaaaga gagctgcgcg ggcacggtgt tgccatctgc
    14941 ggccgggagg tcggcaagct ctgcgaccag ggcatcccgg tcggcggggg tcagcacgct
    15001 gaggaaccgg cccgtggaga cgccggcgcc tcggggcaca ctcatgacct ccagccggaa
    15061 ccgcccgcgc tgcaactcct ccaggctggc tgcatgcacc cgcaccccga tctccaagtg
    15121 cggcggcagc cgaggctcgt cgggccccac gtccagggac tcaatctgtt cgtccgtgag
    15181 gatcacttcg tcacgcccgt cgagcgcggc ggcctgagcc atccgtacga gggcgtcatc
    15241 ccgagcggag acgcggggcc tacgtgcgcc gaccggagcg cctgggtagc cgtcgggata
    15301 gccggtgcca ctgtccgcga cgacctccgc gagcggcacc atcgtgccga tgccgtaccg
    15361 ctcgtagaac cgctggtggt actccttcca ggcggcggtc ccgtacgggc ggatgctcaa
    15421 gcgggtcaga acgagagcgg cgcgctcgat ctctcgggcg accgcttccg gcagaacgag
    15481 ccgcgcatcc aggcggaggt cgagcgcgac gggatggcga cgcaggcccg gcacgagatc
    15541 tcgcatccgc gccgcgacgc tgtcccggcc gccgtgcgtg gcgcactcct ccaggcccgc
    15601 ccggatggcg tggagttcgc gtacggtctc ggcgaccggg gcgaggctgc cggcgtcgac
    15661 cgcgtcgagt tggcccacca gatacccgag ggcgtcggtc tccttgctcg gagcgtgcag
    15721 acccgtgatc agtacccgcc gccggatcag ctccgccagc agttgacgcg ccttcgcggg
    15781 accggcctcg gggaactccg cctggagctt gtccacgagg gtgccgaacc ggatcggcac
    15841 cccggtcgcg gccaggaccg cgcgcaccgg tccagtcagg gccaaagacg cctcgaccgc
    15901 gcgagtccgg tcgtcctggg cgtcgggctg gaacggcacg atgagccggt ctccccgata
    15961 cgtcacggtg ttgttgatga cgacgggcag ccgttcgagg aggtccgggc atgactccag
    16021 ccgtgcgacc agggccgcca gccactccgc ccctgcccgg ccgacggtca cgtgctcctc
    16081 gctccagtcg gcccgcgcct gggggccgaa ctccgcggtg gccacgccgg cgaacaggcc
    16141 gaagggcgtc gcccggtgtt gggctcgcag caggtagcgg gccacgggca gcgccgcgcg
    16201 ctgcacatcc cggaggactg ggtgctcggc cgtgcacagg gcccctacct gcgcggccag
    16261 gaccgggctg gagtaccgga gggcctcggc gacgtccttg tccgcccagg ccgcgcgtag
    16321 ccacgccaca caggcagacg caccactggg cgagcggtcg tcgaggtcag ggcatggagg
    16381 aaacggcagc gagggccggg ccacggcacg cacgagagcg gtggaaccgg cgcggaacac
    16441 tgcaggcgaa gcaaccacca agtacctccg aaggtgaggg ggcgggcggc tggtgccgcc
    16501 gcgcggagac gcggcggcac cagaccgggc tgacctgagg gccgggttag gcgacgttgg
    16561 tggtgcaagc gccgcaggtg gatccgcagt tgtcgtcggt caggttgacc agacccgccg
    16621 ggtcggcgat ctcgacgagg gagacgtcca ggtcgaagcc gtccgaggcc cccggaatct
    16681 gcgggcgtac ttcggtacgg ctgggaacta cggtgctgcg cgtcatgctt caactcctcg
    16741 taatcgttgt ggtgttactg ggctggagcg cccaccaggt gcccacggga gcggtgccgg
    16801 atggctgctc ctcgacagct cctggctgcc cggcgcgagg tgacgtgctc cgcgtaggaa
    16861 gtcctcgcgg gctgcctgca tcacgccggg aagtcgtttg cggggactct gatcaagcgg
    16921 acgccggccg ccgctccatg aagtaggcga gcgcctgggc ctgcaggcga tcgaggcacg
    16981 gctcgcacgc gtcgaagggt gcgtgctgcc cgtcccactg caccggtccg agccagatca
    17041 ccaggactcc ggtacgcccg cagccgagcc agcagtcacc ggtgatccac ggccactcca
    17101 tggaaggacg tccccttttc agctggtcgg gatggtcgat ctggcggcct ggcagtgggg
    17161 agcgcaggcc cagagctggt acggcaggcc ccggtggcgt atctcgccca gccgtcgccc
    17221 actcgctccc agccagcggg cgcagagggc gcagtccatg gccatctgct ggcggggccg
    17281 gagtctggcg agatccggaa ggggcgaggg tgccgtggcc gggatactca ctcgccgccc
    17341 ccggtgctga gttccgccca gacctctttg ccccaggggc gtctgcccga gccatgcagg
    17401 tcgtagcccc agcggtcggc gacagcatcg acgaggagca gcccacgccc cgactcgtcg
    17461 tcgtcacccg cctggccgag tatgggcaga cgcgtcggtt cccggtccac gaccccaaca
    17521 cgcactcgcg tcgcgctcgg ccgcccgacc gtgaggcgga tctcgggaca cggagtgtgc
    17581 cgggcggcgt tcgcgatcag ctccgtgacg atcagcgcgg cacggtcggc gaggccgtcg
    17641 atgtgccaca caccgaggac ggctcggacg aggtcgcggc cgatctcggc cgtggacggc
    17701 tcgcacggga aggtctggct gtacgtgggg tggccgacgg atgggacctc aactggtttc
    17761 ctcagactcg tcattgggtg gagccttcgt gtcgtctcgg cgcccggccc gcccccgcgg
    17821 gggaaacctc gggggcgggc cgggccgtca acagccgccc gcgaggtggg catgcgagcg
    17881 accagcaccc agacaactcc ccttcccagc aggctggtta ggacgttcag gtggtcagcc
    17941 gacggaccga cctagggcgt tttgactccc cctttacctg gcgggcgggg attgtgcggg
    18001 ctaccgtgcc cgcatggaca ccacccgcaa caccgttctt gaggcgtgga tgaccgaaca
    18061 cggctacagc tccaacagcc tcgccgaggc cgtgaacagg gccattgaac ggttgaccgg
    18121 gcgccctgga ggactcgacg gctcgtcggt ccgggcatgg aaagcgggcc gggtcacgtg
    18181 gccaaagtcc gctgctcgca gcgcacttga ggccgtcacc ggactacccg ccgtcgcttt
    18241 agggttcgtg ccacggggcc tgccttcgtc caccccggcc acaccgcagc aggaggaccc
    18301 cgacatgaag cgccgtaccc tcgtcggcag catcgcggcg gctgccgcag cagcagccgc
    18361 cgcacccggc accgcatcgc cgcgccgtat cggcatgagc gacgtcaacc gcctcaacaa
    18421 gcgcttcgcc gagatcatcg ccagcgacca ccgccacggc ggacaactcg gcatcgaaca
    18481 gcgggccgcc gccctcgccg acgaggcact caacctccag aacgccggca gcgccaccga
    18541 gcgcgtacgc agcaacctct acgcctccgc agccgccttc cgctcctccg cgatgtgggc
    18601 cgccatcgac ggccggcgct acgacgtcgc caaggcgcac atgcgcgagg cccaggccct
    18661 cgccgagatg tccggcgacc aggcgatcaa gttccgcatc tggagccacg cgggaaccat
    18721 gtatcgccac atgggccgac ccgccgacgc actcgccgcc aacgacgtcg cccgcaacct
    18781 gcacctcacc cgccgagacc ccctgttcgc ctccctcggc ctggcccgcc agggcgccat
    18841 ccacggcacg gcacaggacc gcacgggcac ccgccgtgcc tgcgagcagg ctcaggacgc
    18901 catgctgcgc gccgatcccg ccgactaccg gccggtgtgg atgctcgcct tctacgacca
    18961 agccgagttg gactccctgg ccctctccgc gcacttggcg ctcggcgact actcgaccgc
    19021 cgagtaccac gcccaccgct gcctgtccgc cctccggccc cacatgatcc ggtctcgggc
    19081 catcaccacg acccggctcg cacacgccca gctcgcacag ggcgcccccg acgccgccac
    19141 ggccaccgcg atgaaggtcc ccgccgaggc cgccacccag cacgccaggg tcacgcgcat
    19201 gctgcaggag ttcggggccg cactgcgcgc caccgcgccg ggcagctcca ccgtgcaaac
    19261 ctggaccgag cacagcgccg cctggaggat ggctgcatga caacggcgcc cgccatcgaa
    19321 ctgcgcacct tcaccaccct cgacacagcc cgcggcgacc tcctcgacgt gtacgccgac
    19381 gtacgcgccc cactgctcca cctgccgaac tacgcggtca ccgcgttcgg cgaacgtctg
    19441 gaccggcacg gcgccgagcc gggcttcaca gccgtcctcg catacgcaga cgggcacccg
    19501 gtcggctacg cctacggcaa caccatcgag cacggcgacc gctactggca gcgcaccagc
    19561 ccgacgccgg ccgagaagta cacagaacgc ccggccgtgg ccctgaagga gatcggcgtc
    19621 cgcccgacct ggcggaagac cggcaccgcc cggcgtatcc atgacgcact cctcaccaca
    19681 cgcaacgagc cgtacgtcac gctcatggtc aaccctgccg ccggcgacgg aaaggtccac
    19741 gtgctctaca agtcgtgggg ctacggagac atcgggcaga gccagccgtc accggcctca
    19801 ccggtcctca ccgtgatgat ccgagccatc cgctgacaga tccccacgac agcccgctgt
    19861 gctcgagcga cgcggcgcaa acgcgacggt catgccctcg gccacacggg acgcgcaagg
    19921 gcgactcagt ctcggcacac gcgcagcatc ttggcctgaa acatcctctt ccacgggaat
    19981 cgcgtggggc ttcaccacac gtcagcaagc catctgggca cgagcggctc gggagacgat
    20041 cttcggcagc tgccgctccg gggcaagcga accgacggtg cctcccccgc gcagggggta
    20101 tgtcatcgtc gggaacaaga gtcgggactg gtgcagggtt gggtgacacc tgacctggct
    20161 tgctgagagg cggcctggaa ggatgtcgca gtgcccaagc cgtatcccaa ggagttccgc
    20221 gaggacgtcg tgcgggtcgc gcgcaaccgc gagcccggcg tcacgctgga gcagatcgcc
    20281 gccgacttcg gcgtccaccc gatcacgctg tcgaagtggc tgcgccgcgc cgataccgaa
    20341 gagggcacca ggcccgcaac ggcatcgggt gagtcggctg agctgcgcga ggcccgcaag
    20401 cggatccggc tgctggagca ggagaacgag gtgctcagga gggctgcggc gtatctgtcg
    20461 caggcgaatc tgccggcaaa atgatgtacc cgctcgtccg cgagctggcc gccgccgctg
    20521 ccccatgccg ggtgccggtg gcggtgacgt gccgggtgct cgggctggcc cgccagccct
    20581 actaccggtg gctggcccgg cctgccaccg acgccgaact gaccgaggcc taccgggcca
    20641 acgccctgtt cgacgcacac cgcgacgatc ccgagtacgg ccaccgcttc cttctcgacg
    20701 aggcccgcgc tgccggtgag gcgatggccg agcggaccgc ctggcggatc tgccgggaca
    20761 acggctggtg gagtgccttc ggcaaacgca ggggccgcgg aaagaacgcc aaagccgggc
    20821 cgccggtcca cgatgacctg gtgcggcgga acttcacagc ggacgggccg aaccggttgt
    20881 ggctcacgga catcaccgag cacgcgaccg gcgagggcaa gctgtacctg tgcgccgtca
    20941 aggacgcttt ctcgggccgc atcgtgggct attccatcga cgcccgcatg cagtcccgcc
    21001 tcgcggtcag agccctggag tccgccgtcg cccgccgcgg ccccgtcgcg gggtgcatcg
    21061 tgcactccga ccgcggatcg caattccgct cccgcaaggt cgccgccgtc ctcacccggc
    21121 acggcctggt cggctcaatg ggccgggtcg gcgccgccgg cgacaatgcc gcgatggaga
    21181 gcttcttcgc gctgctgcag aaaaacgtcc tcgaccgccg tacctgggtc acccgccagg
    21241 agttgcggat cgcgatcgtc acctggatcg aacggaccta ccaccggcgc cgacggcaac
    21301 gacgcctggg ccgattgacc cccgtcgagt acgagaccat catgacccca cccgcagctc
    21361 tggctgcata aaacccgctg tcacccgatc atgcagcagt ccctctcgac ctccaacgcg
    21421 cactcaagga agaccttgac gaacgagcta cgcagaccag cgaggccaca gtcctcttct
    21481 ccgagttcgc ccagcgcctg tacggctcag gacgccaggc atacctggag ttcgacgccg
    21541 gccctagcag cctgcgaatc gtcccgcatg tggacagcga cgacagtcgc ggcatcggca
    21601 acatggtgat cttctgcttc gacctcacca tggcggtcgt cgctcaccgc cacggtcgcg
    21661 gtcccaactt cctcgtccac gacagccacc tcttcgacgg cgtcgacgac cggcaactcc
    21721 gcgacgccct ggaactggca gcggaggtca cagaacggga aggcatgcag tacgtcgtca
    21781 cactcaactc cgacgacctg gagaaggcgc agcgcaaggg atacgacgcg tcggggaggg
    21841 tactgcctgt gcggttggac gacgagtacg acgacggggg gctattcggg ttccgcttct
    21901 gagagtgtaa gcgcagccag gtctcaatca tccccatctg acgcagtacc ccgaactgcc
    21961 tccacccccg cgcccctcac gccgtgagcc gtatgcagta gtccatcagg ccgcgtggtc
    22021 actccgttac cggatcggcc ccgtcacgga gtcgcccatt gatgagatca gtgatccagg
    22081 ccgtgatacc cgaggtgagg gcagcgaacc tgtctgccaa tgaggcgaca tccttttgaa
    22141 cgagcggagc tatctctagc cccatcttta ggcggcgcgt ccgcatcgtg acgggcccgt
    22201 cgtctccacc gaacatcgcc gcgccgtgga cgtacctgtg ccgctcggtg aacaattcgt
    22261 tgctctcccg cagcatgccc ttcaagtcct cgcgcgcatg ggccgtgagc tcttcgtgtg
    22321 cgtcaacgag gacgtggcac accttgatgg tgcggctgct gctctcggcg aggatcagca
    22381 actcgccgta gtggctctca cagagaatgc gtgccgtcag ctccaggcgg aactccagct
    22441 gagcggcctc tctgatcatg cgtccgagtg ccatgtcgag agcactcgtt tcggtatcgg
    22501 cgtgaggagg cgtcatcctc gaagctacca cggcagccgc aacgcagttt gggtacgatc
    22561 cctggcggtt atgcagctca cgggagcgta ctgcagcgca gctgaggcgc agcccagtgc
    22621 cgggcagcca cctctcaggc gcgtcgctcc cggtgacgca tgccgaaccg ccaccatccg
    22681 atctggctga ccgggcgacc ggtcagatcg ggaacccggg cactctgtcc tgcagcctgc
    22741 ccctctttcc atcgaacacg gctgctgccg ccttgacctc gttccttccg gcgcaacaga
    22801 cctttccgta gctcacgtcg tccgtgacct gctcgagaag atccacgtac tgctgatgtc
    22861 caagtgcctg accgcactgc agaagccagc tggcgccgtc acgagccagg gctacaaaag
    22921 cgtgtggggc ctttctgcct tcggggcctc taaccacgtc atgcagctcc tgcacggcgt
    22981 ccacagcgtc ctgcaggcgc ctcacatcgt tcggatgggc cacggagtcc cgcagccgga
    23041 cccgcgcgtc ggcagtgcgc aggagacgat cgtcctgacc ataccggcat gccctgcccg
    23101 ccgccagata gttccgggcg aggtcgaatc taccctggtc gatctcgaat tcggctcgct
    23161 gcagccaata gtgccggtcg tcctgcaaca gctcgtgggc tgcgtgataa gtccgacgcg
    23221 ccgcttcggg gggcaggccg aattcgcgca taacgttgtg actcagcaac cgaatcatcg
    23281 cccgccggtc ggggtgttgg tcgtcctcgc tatgacaggc gcgctccgcg taggagacca
    23341 gcagcttggt catcacggtc tccaactcct tcagccgctt cgtcagcacg gtgtgcacaa
    23401 cggtgtccgc gatggtgcgc tgccggcagc ggagcagccc tccggacatg gctacaagca
    23461 gccccatttc ctggagtccc ttgatggcct cccggtgcga ccggtccggc gggtcggggt
    23521 aggagatgac ctccaagagg ccggtcgaac ttataccaat ctgccggaaa atgtcatctg
    23581 aattgacgat acaaacggcc gcatatgccc actggtaaac ctgaccgtac ttactgaggt
    23641 cttcgtattc actcaccacc ttctctcgga gcgtggaacc cgtcaccgcc tcgatcattg
    23701 cggcaagcaa ccccttctcg gacaggtccc gcaaacgatc cacttttgcc tgcataggcc
    23761 ggtacttctt cagatcgcca ataagcgcgt tcttctgcag agccttgacg agattcttca
    23821 gatcaccgtc ggtcaagggg cagtcgaagt cgacgacctc cgccggaaat ccctcaggga
    23881 tctccgactg ccgagtcaca cgaatggctg cgacgaccag cctcttgccg ccgtcattca
    23941 gactgtgcat gaggtccgac gcgctccgcg tgaaaatatt gacgtcgtcc acgaagatcg
    24001 catcaaggtt ctgttgccgt gcctgcgctg ccacggcccc cgaggtcagg ttggccgcgc
    24061 ggtcgaccca acccacatgc gaactctttc tgtgcagctt ataagcaagt tgcatcaacg
    24121 cggtcgtctt ccccgaacca gcgctgccct tcactagaac gaccggcatc cgcccttcgg
    24181 ccgagggctg cgtgcgggtg gcaatggcgt cgatgagtga gagctgggcg ctgatcttcc
    24241 tgtccttgat gtcaccccac gtggggtccc gtccctccag gaacgatgcg taaccgggag
    24301 gcgtgtcctg caccagctgc gccacccgct ggacccctac gtcgcgcagg gcccctgcgt
    24361 gctcctgcgt cagcaagcgc ttgcccaaga ccagggactg gtttccgggc gcaagttgtc
    24421 tgctgacaaa gtccgaagga gcggtgcgga tgtgctgcag cctcgtctga cgcagccgtg
    24481 cccgatcggt cgcggtcccc tccggagcta cgagaaatcc cggaaactcg tactccccgg
    24541 agagccggcc cgccatgcgc agggtgtccc acagagccgg gctgttcggc gatagcgcca
    24601 caaagagcac cggccgttcc agcagttcag cgcggaagcg gcggagccac tggcggcggg
    24661 catgacgcgg tgactcgtcc tcggcgtcgc cgaagttctg tgagatctcc tcctggggca
    24721 ggccatgcat cgcaacgacc tccaggacct cgcgcttgtc ggtcgggggt tcctcgcagg
    24781 cgttgactag cgagatgcgg tccgtcgtgt ccgcggcccg ggctagcttg aggaggtcac
    24841 taccggtgaa gtcgtagatc cgcgaccagg gcgcgcgcat caggcgatgc acgttggcgg
    24901 gtacctcgcc gtccgggacg cacagctcac tcaggtactg ggctcgttgt tccccggtca
    24961 actgcgactg agccgcagcc caggtctcgc gaaggggcgg cgcggagggc gacggcactg
    25021 ctccgaacac agcttcggcg agctggtggt tcagttcgtc gaggccgatg ggaggcccgg
    25081 cctcggggcc tgagacgagc acgagggcca tccgtccggt ggacaggttc tggtggaaag
    25141 catcgaggag gggcttctcg tcgtagggtt cctccgcggg ctggacgacg cgcagctgcg
    25201 ggccccggac agcactcccg ggccggacag ccgtactgat cgtctggccg tcgccagcat
    25261 ccttgaccac tacccgcctg tcgccgaatt gtgtgcgcag cagccggtgc ctcacggcat
    25321 cgcccgctgg cagcacccac cccgcgctcg actcaccgct tccggcgagc ttcaccaagg
    25381 gcgcggtctc cgaaggcagt tcgggccagg cgccagactg gccagccgcc accagtgtga
    25441 gggcgttgcc ttcggcccag gctgcgaagt cgcccccgac ggcgaggtcc agctgctccc
    25501 tgaagcatcc cgcgaggccg ggagcggcat cttcggcgac catgcggaac accgtgttga
    25561 cgctgaccag gcccagcgtt cgtccaccga cctcgacgct cagggatccg tcaccgggca
    25621 gcagaccgcg gtgccatcct tcgatagcac gcgccgtatc ggcatgccag gccgtgatgt
    25681 ccgaaagcac cttagtctcc agcggcgcga caatgtcttc cgtcagctct ccggcccaca
    25741 gctcgggggc ggtccgcgcc caatcctccg tcaggctgcg cgccagaagt cgtgtggcgg
    25801 ggagccgcag gtcggcaggt ccggggatag gtacgacgaa cggttcgtag ccaaggtcga
    25861 cgcatgccaa ctgcacctca aagacaagct cttcggctgg catccggacg ccaaccgtgc
    25921 cgagcacgaa gatgccggtc aaccgacggc ccgccgcgtg taggcggacc acatcgtcca
    25981 gcaccgcggc gctcacggcc tgcctcgcca cctcatccgt aggcaacggc cccaggcaga
    26041 ggaagtgcgc gttcgtatca ccgtcagtca tcttgccacc tcaccgcctt taccttgccc
    26101 cgcggcacct gcagggtcgt gccctgcgtc gtacagacgc ccttgtccgg cctgatttcg
    26161 acgaactgcg ccttgagcga gtccttcact atctccccgc tgacaagtcc cgtgtcagca
    26221 gccttcttgg aacacagagc ccccagagcc gcccgatagc cggagtcgac tacgacggtg
    26281 cctgaaacga cctcctgcgc ggggtccgtc acgatgctca ccgcgaacg
//
