LOCUS       NZ_CP094676            10627 bp    DNA     linear   CON 30-MAY-2024
DEFINITION  Streptomyces sp. CB09030 chromosome, complete genome.
ACCESSION   NZ_CP094676
VERSION     NZ_CP094676.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB09030
  ORGANISM  Streptomyces sp. CB09030
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Genomic of Streptomyces sp. CB09030
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2022) Xiangya International Academy of
            Translational Medicine, Central South University, Changsha, Hunan
            410013, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: Canu v. v1.5; Racon v. v3.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1510.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022827705.1-RS_2024_05_30
            Annotation Date                   :: 05/30/2024 05:11:20
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,205
            CDSs (total)                      :: 7,118
            Genes (coding)                    :: 7,015
            CDSs (with protein)               :: 7,015
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 40 of 103
            Pseudo Genes (incomplete)         :: 75 of 103
            Pseudo Genes (internal stop)      :: 10 of 103
            Pseudo Genes (multiple problems)  :: 21 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:41:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7076379
            Orig. end                         :: 7087006
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094676.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10627
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="35"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10627
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10627
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5627](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5627)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            439..1776
                     /locus_tag="L6J92_RS30180"
                     /old_locus_tag="L6J92_30180"
     CDS             439..1776
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978040.1"
                     /locus_tag="L6J92_RS30180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_30180"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_243782527.1"
                     /transl_table=11
                     /translation="MFSLAMRSVRHRPGRFGATLLASFLGAAIIMAFNSLHDTAGAPGV
                     DDVSSETLGLAAGVVGGYGTLLVFFAVASTLTVNVRQRDEEIALLRSAGATPAQIRWMV
                     VGEAAAVAVVAALLAVGPAVLGGQALLTGFQDSGQVAKDVDHVFGPVAVAAGFGVTVPA
                     SMGAAFLAVRRATRAAAGTARASGRWRRLGGWAALALGTAAVCATFTFDATDPGLMAAP
                     AYGAILLSVGLAVFSPALLRVLLDRLERPLGTLFGASGLLAVQNMRRRATQLSGVLMPL
                     VLFTGMATGTLYMQSIENDAIDASGLTRSVEDKNLETLNLTVVGIIVVFSCIMLINSLY
                     AATSYRRREFGQQRLAGATPGQVLGMVGVEALVLTVSGVVLGSAAAVAGILPFSSVRAS
                     ALVPDQGLGTWLGIVAVAAAATLATSVVTARRTLRTPAVRAVAATA"
     gene            1938..2903
                     /locus_tag="L6J92_RS30185"
                     /old_locus_tag="L6J92_30185"
     CDS             1938..2903
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325456.1"
                     /locus_tag="L6J92_RS30185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_30185"
                     /product="D-2-hydroxyacid dehydrogenase family protein"
                     /protein_id="WP_224292191.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 2.6e-51, bitscore:
                     172.2, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRCAVLDDFQQVAKEAADWSPVAGEVDVVSFDAHLPDEDALAA
                     ALADFDIVVTLRERVAFPGSLLARLPRLRLIVASGMRNSVIDYAAAEAHGVTVCGTASS
                     STPPVELTWALLLGLARGLVRESNGLREGGPWQQTVGADLHDRRLGLLGLGKIGSRVAQ
                     VGLAFGMRVSAWSQNLTRERADEVGVELAPSREELLRTADFVSVHLALGERTRGLLGPA
                     ELALLKPTAYLVNTSRAAIVDQDALLAALHEGRIAGAGVDVFDTEPLPAGHPMRTAPRL
                     LATPHLGYVSQANYATYYGQAVEAIRSYLAGSPVRRLPAP"
     gene            complement(2953..3525)
                     /locus_tag="L6J92_RS30190"
                     /old_locus_tag="L6J92_30190"
     CDS             complement(2953..3525)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976102.1"
                     /locus_tag="L6J92_RS30190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_30190"
                     /product="DUF2087 domain-containing protein"
                     /protein_id="WP_243783133.1"
                     /transl_table=11
                     /translation="MASAVAALPALFAEESRVRAFAAVALGAGDAAQVARAAGLSAKET
                     AGALRRLREHGVVTSGDDGALVVAQGRFRELARAARPAAAAGTPGAAGGGREGMILRTF
                     VKDGRLVRLPARWTRKKVVLRHIAEQTFAPGVEYPERTVDGKLRAWCEDGEVDHVTLRR
                     HLVDFGHLRRSGGTYWRPAEPARAGTA"
     misc_feature    complement(3653..3668)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.87"
                     /tool="antismash"
     gene            3769..4047
                     /gene="chpF"
                     /locus_tag="L6J92_RS30195"
                     /old_locus_tag="L6J92_30195"
     CDS             3769..4047
                     /codon_start=1
                     /gene="chpF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028524.1"
                     /locus_tag="L6J92_RS30195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_30195"
                     /product="chaplin ChpF"
                     /protein_id="WP_031040144.1"
                     /transl_table=11
                     /translation="MSRIAKAAGVVLGAGAVALSGTGMAMADAGAQGAAVGSPGVLSGN
                     VVQVPVHVPVNVCGNTIDVIGLLNPAFGNSCENESGHHSDKSGGYGG"
     gene            complement(4151..5017)
                     /locus_tag="L6J92_RS30200"
                     /old_locus_tag="L6J92_30200"
     CDS             complement(4151..5017)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325459.1"
                     /locus_tag="L6J92_RS30200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_30200"
                     /product="tyrosinase family protein"
                     /protein_id="WP_243782528.1"
                     /transl_table=11
                     /translation="MAYTRKDVSTLTRTEKRRFVNALLEIKRRGEYDEFVRTHIEYYVS
                     DGENGLRTAHMAPSFLPWHRRFVLDLEEALRRVDSSVTVPYWDWTKDRGAKSTPWTADL
                     LGGTGRHSDRRVTTGPFAHAEGNWTLRENVTDTEYLTRDLGRAADPIDLPSKSDLEWAL
                     DDATYDTSPYDSTVRKGFRNKLEGWGTGRGSVSWRNHNRVHRWVGGAMVGGASVNDPVF
                     WLHHAFIDLQWSRWQARHRGARYLPAEPPGRGSAQRGRIVARHEKLPPWDVTPDEMEDV
                     GRIYRYA"
     gene            complement(5001..5627)
                     /locus_tag="L6J92_RS30205"
                     /old_locus_tag="L6J92_30205"
     CDS             complement(5001..5627)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028525.1"
                     /locus_tag="L6J92_RS30205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_30205"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_243782529.1"
                     /sec_met_domain="melC (E-value: 1.8e-46, bitscore: 156.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVNAGAPVSGAERKREHPPEGGGLAGNGSSGGGAADGGPASGRA
                     TSAAAASGTRRQMMRGLLAPALAVTLVPLVAASRPFRAEATAQGADAAPPGPRAAERAG
                     QETGGTAFDETYRGRRIRGIRSAAGRAVGAGTWHVTVDGRPLHLMRRADGSWLSMIDHY
                     RSYPTPLAAARGAVDELGPAEQVRDTPGDDAGHDHHTGGRHGVHA"
     gene            complement(5750..6265)
                     /locus_tag="L6J92_RS30210"
                     /old_locus_tag="L6J92_30210"
     CDS             complement(5750..6265)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976098.1"
                     /locus_tag="L6J92_RS30210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_30210"
                     /product="hypothetical protein"
                     /protein_id="WP_194277642.1"
                     /transl_table=11
                     /translation="MRPTTRRTLAAVVTGVAAALGAAATPAAAAGAVPVPVPLDGAETA
                     LGMELPEVTGALPVPTAGAPEGPRYVEGRLLPERTLPQLPVHAGLPGADVRQPLPRVLG
                     DDFDHAALDAPAAELRTLAPGLSLDAPLTAPNPEALGLPSAKLPEVGVLTPVLQTGPVA
                     DLGVGPGL"
     gene            complement(6343..6633)
                     /locus_tag="L6J92_RS30215"
                     /old_locus_tag="L6J92_30215"
     CDS             complement(6343..6633)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325462.1"
                     /locus_tag="L6J92_RS30215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_30215"
                     /product="hypothetical protein"
                     /protein_id="WP_031040135.1"
                     /transl_table=11
                     /translation="MKSLKAAAVVAGSLVAAGSAVPAFAYDAADTAALTPTSLNGAVNA
                     LTAEPIDIMPIKHQSDALDTENKDSLLHTVKGATTDLNSAGGLLGGLPLGR"
     gene            complement(6805..7593)
                     /locus_tag="L6J92_RS30220"
                     /old_locus_tag="L6J92_30220"
     CDS             complement(6805..7593)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325463.1"
                     /locus_tag="L6J92_RS30220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_30220"
                     /product="hypothetical protein"
                     /protein_id="WP_243782530.1"
                     /transl_table=11
                     /translation="MRLPARRIATSALCAGLLIGLSGPAVMAADGDPVRERTRAASLAP
                     LPDAEELQGQVGSLAGLGDMLAPVTDMLDAILKADSGRLSATDADKLAAAVKDALAKAD
                     AADTGTDTGDAATTPGTTTPGTSTPAQPPAAPDADTPVTLPAPVTAQSDDPAAAAPDLA
                     ATAYAELQKQVDALTEATTAGDAAKVSPAVKEVVTGIVNVVAATMVGNGLPAADLAGLP
                     GVPTAPEAATPEATTPEATAPEAAAPEAAAPANPLPADPS"
     gene            complement(7869..8108)
                     /gene="chpG"
                     /locus_tag="L6J92_RS30225"
                     /old_locus_tag="L6J92_30225"
     CDS             complement(7869..8108)
                     /codon_start=1
                     /gene="chpG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449696.1"
                     /locus_tag="L6J92_RS30225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_30225"
                     /product="chaplin ChpG"
                     /protein_id="WP_007449696.1"
                     /transl_table=11
                     /translation="MSRIAKGLALTSVAAAAVAGTAGVAAADSGAQAAAAHSPGVLSGN
                     VVQVPVHIPVNVCGNTIDVIGLLNPAFGNECEND"
     gene            8371..9846
                     /locus_tag="L6J92_RS30230"
                     /old_locus_tag="L6J92_30230"
     CDS             8371..9846
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325465.1"
                     /locus_tag="L6J92_RS30230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_30230"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_243782531.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 8.6e-22,
                     bitscore: 76.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHLPPIGLRPRVLHVTQPVDGGVARVVTDLTRAQLAAGLRVSVAC
                     PEGGLADRLRALRADVRPWAATRSPGRALPVEVGRLARVIEEVRPDLVHAHSAKAGLAA
                     RLAVRGRVPTVFQPHAWSFEAAGGPTGVLALGWERWAARWAARTVCVSEAERLRGARAG
                     IRGRWAVVPNGVDTDRFHAGSGPGPDDAQDVRRRHGIGPHTPLVVCVGRLCRQKGQDVL
                     LTAWESVLARVPDARLVLAGDGPDRAALTARASANGLLDEPGAAAPPGRHTPARHTPAP
                     PGRHTPAPPPGRGAAASVLFTGAVADASGWYRAADLVVLPSRWEGMALAPLEAMACGRP
                     VVVTDVDGAREALPPALAPRCLVPPEDPEALADAVAGLLLDAPLRASLARDGHAHVRSA
                     HDVRHTATAVARLYGAVLDAARPSDRATAPGPHRALACDDTRTTARRPAPATTGPAARR
                     PAPGDLGQADVPRKHGMPLKRVEPFECRESTHP"
ORIGIN
        1 ccgctcaggc tggcccggcg gcgcgtggac ggggcccgcg cccgggagat cctcacccag
       61 gtcggtctcg gcgaccgcct cgacgccctg cccgaccagc tctccggcgg ccagcgccag
      121 cgcgtcgcca tcgcccgcgc gctggtcacc gagcccagcg tggtcttcgc cgacgaaccg
      181 acgggggcac tcgacacgcg cagcgcccgg gacgtgctgc ggctgctgca ggaggcggtg
      241 cggctgcacg gccggaccgt cgtcatggtg acgcacgacc cggtggccgc ctcgtacgcc
      301 gactccgtcg tcttcctcgc ggacggacgg cccgccggac acctgaccgc accgaccgtg
      361 gacgccgtcg ccgagcggct cgcgcacctg ggcgaccccg ctcccgcggg cgacaccgcc
      421 ggtctggagg tgtgagccgt gttctccctg gccatgcgtt ccgtcaggca ccgccccggg
      481 cgcttcggcg ccacgctgct cgcctcgttc ctgggcgccg cgatcatcat ggcgttcaac
      541 tcgctgcacg acaccgccgg agcgccgggc gtcgacgacg tcagctccga gacgctcggc
      601 ctcgccgcgg gcgtggtggg cggctacggc accctgctgg tgttcttcgc cgtcgcgtcc
      661 acgctgaccg tcaacgtccg gcagcgcgac gaggagatcg ccctgctgcg cagcgccggc
      721 gccaccccgg cgcagatccg gtggatggtg gtgggcgagg ccgccgcggt cgccgtggtg
      781 gcggcgctgc tggccgtcgg cccggccgtg ctcggcggac aagccctgct gaccgggttc
      841 caggacagcg gccaggtcgc gaaggacgtg gaccacgtgt tcgggccggt cgcggtggcg
      901 gccgggttcg gggtcaccgt accggcctcc atgggggccg ccttcctcgc ggtgcgccgc
      961 gcgacgcggg ccgcggcggg cacggcgcgg gcctccggac ggtggcggcg gctgggcggc
     1021 tgggcggcgc tcgccctcgg cacggcggcg gtgtgcgcca cgttcacgtt cgacgcgacg
     1081 gatcccgggc tgatggcggc ccccgcgtac ggcgcgatcc tgctctccgt cggtctcgcc
     1141 gtcttctccc cggcgctgct gcgcgtcctc ctcgaccggc tggagcggcc gctgggcacg
     1201 ctgttcgggg cgagcggcct gctggccgtg cagaacatgc ggcggcgggc cacgcagttg
     1261 tccggcgtac tgatgccgct ggtcctgttc accggcatgg cgaccgggac gctgtacatg
     1321 cagtccatcg agaacgacgc gatcgacgcc tcgggcctca cccgctccgt cgaggacaag
     1381 aacctggaga ccctcaacct cacggtggtc ggcatcatcg tggtcttctc ctgcatcatg
     1441 ctgatcaaca gcctgtacgc cgcgacctcg taccgccgcc gggagttcgg ccagcagcga
     1501 ctggccgggg cgacgccggg tcaggtcctc ggcatggtcg gtgtggaggc cctggtgctc
     1561 acggtgtccg gcgtcgtcct cggcagtgcg gccgccgtgg cgggcatcct gccgttcagc
     1621 tcggtgcgcg cctccgcgct cgtgccggac cagggcctgg ggacatggct gggcatcgtg
     1681 gcggtcgccg ccgcggcgac gctggccacc agcgtggtga cggcccggcg cacgctgcgc
     1741 acaccggcgg tacgtgcggt ggcggccacc gcctgaccct ggaggcccgc cgtacgtacg
     1801 ttgggcggac ggcaggcccg ccgtgcctgc gttgggcgcc gcaccccgtc gtacacgggg
     1861 cgcggcgccc gctgtacgtt gggccgggcg ccccgccggg ggtgtcactg cccgctcggc
     1921 ggaagggacc ggacgacgtg cgactgcgct gcgcggtact cgacgacttc cagcaggtgg
     1981 cgaaggaggc cgcggactgg tccccggtcg ccggcgaggt cgacgtcgtg tccttcgacg
     2041 cccacctccc cgacgaggac gccctcgccg ccgcgctcgc cgacttcgac atcgtggtca
     2101 ccctgcgcga acgcgtggcc ttccccggct cgctgctggc ccggctgccc cgcctgcggc
     2161 tgatcgtcgc ctccggcatg cgcaacagcg tgatcgacta cgccgccgcc gaggcgcacg
     2221 gcgtcaccgt gtgcggcacg gcctcctcct caaccccgcc cgtcgaactg acctgggccc
     2281 tgctgctcgg cctggcccgc gggctcgtcc gggagagcaa cgggctgcgc gagggcggcc
     2341 cctggcagca gacggtgggc gccgacctgc acgaccgccg gctcgggctg ctgggcctgg
     2401 ggaagatcgg cagccgggtg gcgcaggtcg gcctcgcctt cggcatgcgg gtgagcgcgt
     2461 ggagccagaa cctcacccgg gagcgcgccg acgaggtcgg cgtcgaactg gcgccctcca
     2521 gggaagagct cctgcggacc gccgacttcg tctccgtcca cctggccctc ggcgagcgca
     2581 cccgcggtct gctgggcccc gccgaactgg ccctgctcaa gccgaccgcc tacctggtca
     2641 acacctcgcg tgcggccatc gtcgaccagg acgccctgct ggccgcactg cacgagggcc
     2701 gcatcgccgg cgccggcgtg gacgtcttcg acaccgagcc gctgcccgcc ggccacccga
     2761 tgcgcaccgc cccgcgcctg ctcgccaccc cccacctcgg ctacgtctcg caggccaact
     2821 acgccacgta ctacggccag gcggtcgagg cgatccggtc ctacctggcc ggatctcccg
     2881 tacgccgcct gcccgcgccg taggctcgcg cggtcaggcg gttcggacag gcaggtcggt
     2941 caggcaggtc ggtcacgcgg ttcccgcacg ggcgggctcc gcggggcgcc agtaggttcc
     3001 gccgctccgg cgcaggtggc cgaagtccac gagatggcgc cggagcgtca catggtcgac
     3061 ctccccgtcc tcgcaccagg cccgcagctt cccgtcgacg gtgcgctcgg ggtactccac
     3121 tccgggggcg aaggtctgct cggcgatgtg ccgcagcacc accttcttgc gtgtccagcg
     3181 cgccggaagc cggaccagcc gcccgtcctt gacgaaggtc cgcaggatca tgccctcccg
     3241 gccgccgccg gccgccccgg gggtgccggc cgccgccgcg gggcgtgcgg cgcgcgccag
     3301 ttcccggaaa cggccctggg cgacgacgag tgcaccgtcg tccccggagg tcaccacgcc
     3361 gtgttcccgc agccggcgca gcgcgcccgc cgtctccttc gcggagaggc cggccgcgcg
     3421 ggccacctgc gcggcgtcgc ccgcgcccag cgccacggcc gcgaaggcgc gtacccggct
     3481 ctcctcggcg aagagggcgg gcagcgcggc cacggcggac gccacgccgg ccccggtggc
     3541 cggagggaac gcgtgggaca ggtcgttcgg gtcgttcgac atgccgggag gctagtggac
     3601 gccccggcgc gcaggggaac ggttttccgt cgcccctccc tctcgccctc ccgttcaaaa
     3661 agggtgatcc tcacattctc cccgtgaccc gctgcgaccg ggtgcgttga acctgcagtg
     3721 cggcggcgcg tcctgccgtc gcgctccccg agtcagaagg agtacgtgat gtctcgcatc
     3781 gcgaaggccg ccggtgtcgt cctcggcgcc ggtgccgtgg cgctcagcgg caccgggatg
     3841 gccatggcgg acgcgggcgc gcagggcgcg gccgtcggtt cgcccggcgt cctgtccggc
     3901 aacgtcgtcc aggtcccggt gcacgtgccg gtcaacgtgt gcggcaacac catcgacgtg
     3961 atcggcctgc tgaacccggc cttcggcaac agctgcgaaa acgagagcgg ccaccactcc
     4021 gacaagagcg gtggctacgg cggctgagtg ccccgcaggc agcgaagagc cccggccgcc
     4081 ccggccgggg ctcttcccct gcccgcccgt tcagaccttc aagccttcag atctccagat
     4141 ctccaagcct tcaggcgtac cggtagatcc ggccgacgtc ctccatctcg tccggcgtca
     4201 cgtcccacgg cggcagcttc tcgtgccgtg cgacgatccg tccgcgctgc gcgctgcccc
     4261 ggccgggcgg ctcggcgggg aggtagcggg cgccgcggtg gcgggcctgc cagcgcgacc
     4321 actgcaggtc gatgaaggcg tggtgcagcc agaagaccgg gtcgttgacg gaggcgccgc
     4381 cgaccatggc gccgccgacc cagcggtgca cgcggttgtg gttgcgccag gagacactgc
     4441 cccggccggt gccccagccc tccagcttgt tgcggaaccc cttgcggacc gtggagtcgt
     4501 acggcgaggt gtcgtacgtc gcgtcgtcca gcgcccactc caggtcgctc ttggagggca
     4561 ggtcgatggg gtcggccgcg cgtccgaggt cccgggtgag gtactccgtg tcggtgacgt
     4621 tctccctgag ggtccagttg ccctcggcgt gggcgaaggg gccggtggtg acgcgccggt
     4681 cggaatgccg cccggtgccg cccagcaggt cggcggtcca gggcgtcgac ttggcgccgc
     4741 ggtccttcgt ccagtcccag tacggcacgg tgaccgacga gtcgacccgg cgcagcgcct
     4801 cctccaggtc cagcacgaac cggcggtgcc acggcaggaa ggacggcgcc atgtgcgccg
     4861 tacgcaggcc gttctcgccg tcggagacgt agtactcgat gtgggtgcgc acgaactcgt
     4921 cgtactcacc gcgccgcttg atctccagca gcgcgttgac gaaccggcgc ttctcggtgc
     4981 gggtcagcgt gctgacgtcc ttacgcgtgt acgccatgcc gccccccggt gtggtggtcg
     5041 tgcccggcgt cgtcgcccgg cgtgtcgcgc acctgctcgg cggggccgag ttcgtcgacg
     5101 gcgccccggg ccgcggccag gggggtggga tacgagcggt agtggtcgat catgctcagc
     5161 cagctgccgt cggcccggcg catcaggtgc agcgggcggc cgtccacggt gacgtgccag
     5221 gtgccggcgc cgacggcccg ccccgcggcg gaccggatgc cgcggatgcg ccggccgcgg
     5281 tacgtctcgt cgaaggcggt gcccccggtc tcctgccccg cccgttcggc ggcgcgtggc
     5341 ccgggaggcg cggcgtccgc cccctgcgcg gtggcctcgg cccggaacgg ccgggaggcg
     5401 gcgaccaggg ggaccagcgt cacggcgagg gccggggcga gcagcccccg catcatctgc
     5461 cgccgcgtac cggacgccgc ggcggcggac gtcgccctcc cggacgccgg tcccccatcg
     5521 gccgcaccac cacccgacga accgttgccc gccaggcctc cgccctccgg cgggtgctct
     5581 ctcttccgct ccgcgccgct caccggcgca cccgcgttga cgaccatgac tcgctcctcg
     5641 tccgattccg gtggtttccc accgctaacc gcacggcaag ccccgcggtc actgtccgca
     5701 gggccagtcg gagcacggcc gcgccacgga gcgcggagta cgcctggagc tacagccccg
     5761 ggccgacgcc caggtcggcc accggccccg tctgcagcac gggggtgagc acgccgacct
     5821 cgggcagctt ggcggacggc aggccgaggg cctcggggtt cggcgcggtg agcggggcgt
     5881 ccagggacag gcccggcgcc agggtccgca gctcggcggc gggagcgtcg agggcggcgt
     5941 ggtcgaagtc gtctccgagg acgcgcggca gcggctggcg cacgtcggcg ccggggaggc
     6001 cggcgtgcac cggcagttgc gggagggtcc gctcgggcag cagccgtccc tcgacgtacc
     6061 ggggcccctc gggggcgccc gcggtcggca cgggcagtgc gccggtcacc tccggcagtt
     6121 ccatgccgag ggcggtctcg gcgccgtcca gcggcaccgg cacgggaacc gcgccggccg
     6181 cggcggccgg ggtcgcggcc gcacccaggg cggcggccac gccggtgacg acggcggcca
     6241 gggttcgtct ggtggtcggc ctcatgtcag gcacggcccc tttcgagaat gcggggaaac
     6301 agtgggggga agagcggagg aggatgccga gggagaagcg gctcagcggc ccagcgggag
     6361 gccgccgagg aggccgcctg cggaattcag gtcggtggtc gcgcccttca cggtgtgcag
     6421 cagggagtcc ttgttctcgg tgtcgagcgc gtccgactgg tgcttgatcg gcatgatgtc
     6481 gatgggctcg gcggtcagtg cgttcacggc gccgttgagg ctggtggggg tgagggcggc
     6541 ggtgtcggcg gcgtcgtacg cgaaagcggg cacggcggaa ccggcggcga ccagggaacc
     6601 ggcgacgacg gcggcggcct tgagggactt catcgtgttc ctttcttcga cttttcctcc
     6661 ctaacgatct gccgaggacc cggaaactcc gccgtccgga agacatatga gatctccgga
     6721 gccgagattg cccgaatagc ggaaaggccg ccgcgccgtc cgacagggag gcgcggcggc
     6781 ccgtgaggcc gacgtcggag aaggtcagga ggggtcggcg ggcagcgggt tcgcgggcgc
     6841 ggcggcctcg ggggcggcgg cttccggagc cgtggcctcc ggagtggtgg cctcgggagt
     6901 cgcggcctcc ggcgcggtcg gtacgccggg caaaccggcc aggtccgcgg cgggcaggcc
     6961 gttgccgacc atggtggcgg cgacgacgtt gacgatgccg gtcaccacct ccttgaccgc
     7021 cgggctcacc ttcgcggcgt caccggcggt ggtggcctcg gtcagggcgt cgacctgctt
     7081 ctgcagctcg gcgtacgcgg tggccgccag gtcgggcgcc gccgcggcgg ggtcgtcgct
     7141 ctgcgcggtg acgggcgccg gcagcgtgac gggggtgtcg gcgtccggcg cggccggggg
     7201 ctgggccggg gtgctggtgc cgggggtggt cgtaccgggg gtggtcgccg cgtcgccggt
     7261 gtccgtgccg gtgtcggcgg cgtcggcctt cgcgagggcg tccttgacgg cggcggcgag
     7321 cttgtccgcg tccgtggcgg agagccggcc gctgtcggcc ttgaggatcg cgtcgagcat
     7381 gtcggtgacc ggagcgagca tgtcgcccag accggccagg ctgccgacct ggccctgcag
     7441 ctcctcggcg tcggggaggg gcgcgaggga ggccgcgcgg gtgcgttccc ggaccgggtc
     7501 gccgtcggcc gccatcaccg ccggacccga gagaccgatc agcaggccgg cgcagagagc
     7561 ggaggtggcg attcgccgtg cgggcagacg catgaggggg ttcctttcgg tggcgcgtcg
     7621 gatcttgtgc ccaccgtgga agcggccccg gcgctctgca accgagcggt gacccggtgt
     7681 gcccggccgc accggccgcc gttcgcgtct tacctggtga gacgccctgt caaggtccgt
     7741 gatccgtgtc ggcgcccgga ccccccattc ggggcagcac accaccgtcc gcgcggcaac
     7801 gcgaaccggc cgcccgctcg cggaagaacc gcggtacgga cggccggtgc gggagtcgcg
     7861 agccgacgtc agtcgttctc gcactcgttg ccgaacgccg ggttcagcag gccgatgacg
     7921 tcgatggtgt taccgcagac gttgaccggg atgtggaccg gaacctgcac cacgttgccg
     7981 gacaggacgc ccggggagtg ggcggcggcg gcctgcgcgc cgctgtcggc ggcggcgaca
     8041 ccggcggtgc ccgccaccgc ggcggcggcg acggaggtca gggccaggcc cttcgcgata
     8101 cgcgacatgg agaagtgctc cttggggttg cgacatacat ccgggcgggg gtgcccggcg
     8161 cagtgtcaac gcgtggcagg tacgggagtt gtgccgccaa aggggtgatg tcgccgggga
     8221 ccgccattca caaatccaac acacttcccg gtttcaccgt attagtacgg atagcggcta
     8281 gagtcccaca ccgttcgacg cacctctgtc acgcccctgt cgcactccgt ttgcgcccct
     8341 gtctcaccca tgccgcgcaa ggacacgcgt atgcacctgc caccgatcgg cctacggcca
     8401 cgggttctgc atgtcaccca gccggtggac ggcggggtcg cccgggtggt gacggacctg
     8461 acgcgtgctc agctcgccgc cgggctgcgg gtgtccgtcg cctgccccga gggaggtctc
     8521 gccgaccggc tccgcgccct gcgtgcggac gtgcggccct gggcggcgac gcgctcgccg
     8581 ggccgggcgc tgccggtgga ggtgggacgc ctcgcccgtg tgatcgagga ggtgcggccc
     8641 gacctggtcc acgcccacag cgccaaggcc ggtctggccg cgcggctcgc cgtacggggg
     8701 cgggtcccga ccgtgttcca gccgcacgcc tggtcgttcg aggcggccgg cggacccacc
     8761 ggggtcctcg cgctcggctg ggagcggtgg gccgcgcggt gggcggcgcg cacggtgtgc
     8821 gtgagcgagg cggagcggct gcgcggggcg cgggccggga tccgcgggcg gtgggcggtg
     8881 gtcccgaacg gcgtcgacac ggaccgcttc cacgccgggt ccggccccgg cccggacgac
     8941 gcgcaggacg tacggcgacg gcacggcatc ggcccgcaca ccccgttggt ggtctgcgtg
     9001 gggcggctgt gccggcagaa gggccaggac gtgctgctca ccgcgtggga gtcggttctc
     9061 gcgcgcgtgc cggacgcccg gctggtcctg gccggtgacg gaccggaccg cgccgcgctc
     9121 accgcgcggg cgtcggcgaa cggcctcctc gacgaaccgg gcgccgccgc gccgcccggc
     9181 cggcacaccc ccgcgcggca cacccccgcg ccacccggcc ggcacactcc cgcgccgccg
     9241 cccgggcggg gcgccgcggc gtccgtgctg ttcacgggtg ccgtggccga cgcctccggc
     9301 tggtaccggg ccgccgacct ggtcgtcctg ccgtcgcgct gggagggcat ggcgctggcc
     9361 ccgctggagg cgatggcctg cgggcgcccc gtggtggtga ccgacgtgga cggtgcccgc
     9421 gaggccctgc cgcccgcgct cgcgccgcgc tgcctggtgc cgcccgagga cccggaagcc
     9481 ctggccgatg cggtcgccgg cctcctgctc gacgcgcccc tgcgcgcgtc gctcgcccgc
     9541 gacggccacg cccacgtccg ctccgcgcac gacgtacggc acacggccac ggcggtcgca
     9601 cggctgtacg gcgccgtact cgacgccgca cgtccgtccg accgggccac ggcccccggt
     9661 ccccaccggg ccctggcctg cgacgacacc cggactaccg cacggcgccc ggcccccgcc
     9721 accaccgggc ccgccgcacg gcgcccggcc cccggcgact tggggcaggc cgacgtgccc
     9781 cgcaagcacg gcatgcccct caagcgcgtc gagcccttcg agtgcaggga gtccacccac
     9841 ccgtgaccgc ggaaagcacc gtccccaccc ccgccggccg gcctcggggc ctcggcccgt
     9901 cccccgtctc ggtgctgccg cagcgggccg gtgcggcggg cggcggcccg cgactgcccg
     9961 cccggcgtac cgccgcccgg cccgactccc cgctgccgtt gctcgtcgcg gacggcacgg
    10021 cggccctgcc gggctcgctg atgctcaccg gcgccccgca ccagcccctg ctcgccgccc
    10081 tgctggtcgg cacctcgctc ctgctgcgcc ggaagccgga cccggccgcc gcccggccgg
    10141 tcttcggcgt gctggacgaa ctgccggcgc tgtgcgcccg catcgcggtg gtctggctgg
    10201 cactggcggc gctcgtcgcg gcgtacgccc cggcgcaggc gctgtccgcc cgcacgctgc
    10261 tcgccggttt cctgctgcac gcggcgacgg gctgcgccgg ccggggcgcc gtgcaccgca
    10321 ggcgccgcag ggcgctgtcg aaccgtcccc gcgcggccct cgtcgtcggg cccgccgcga
    10381 ccgcccagcg ggtggcgtcg gcgctgctgc gccacccgcg ctgcggggtg cgtcccgtcg
    10441 gggtcgtcac cgacgacccg gacggcaccg cgggcctgcc cgtgctgtcc acgggtgagg
    10501 aggcgcggcg ggcggtggtg cagaacggcg tgcgggacgt cctcgccgtg gcttccgccg
    10561 tacgtccccg gcaggcggcg ctgctgcgga cgctggccga gtcgggctgc acggtgtggg
    10621 aggtcga
//
