LOCUS       NZ_CP094676            10399 bp    DNA     linear   CON 30-MAY-2024
DEFINITION  Streptomyces sp. CB09030 chromosome, complete genome.
ACCESSION   NZ_CP094676
VERSION     NZ_CP094676.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB09030
  ORGANISM  Streptomyces sp. CB09030
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Genomic of Streptomyces sp. CB09030
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2022) Xiangya International Academy of
            Translational Medicine, Central South University, Changsha, Hunan
            410013, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: Canu v. v1.5; Racon v. v3.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1510.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022827705.1-RS_2024_05_30
            Annotation Date                   :: 05/30/2024 05:11:20
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,205
            CDSs (total)                      :: 7,118
            Genes (coding)                    :: 7,015
            CDSs (with protein)               :: 7,015
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 40 of 103
            Pseudo Genes (incomplete)         :: 75 of 103
            Pseudo Genes (internal stop)      :: 10 of 103
            Pseudo Genes (multiple problems)  :: 21 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:41:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6078186
            Orig. end                         :: 6088585
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094676.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="34"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(231..1322)
                     /locus_tag="L6J92_RS25890"
                     /old_locus_tag="L6J92_25890"
     CDS             complement(231..1322)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989359.1"
                     /locus_tag="L6J92_RS25890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_25890"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_194278194.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 9.6e-18, bitscore:
                     63.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRAVLHVKGRVLVGPEEVRDEVWVIDGRISYDRPAGAADVRTV
                     EGWALPGLVDAHCHVGLDRHGAVPADAAEKQALSDREAGTLLLRDAGSPSDTRWIDDRD
                     DLPKIIRAGRHIARTRRYIRNYAWEVEPDDLVAYVAQEARRGDGWVKLVGDWIDRDLGD
                     LSACWPRGAVEAAIAEAHRLGARVTAHCFAEDSLRDLVEAGIDCVEHATGLTDDTIPLF
                     AERGVAIVPTLVNIATFPALADGGESRFPRWSAHMRRLHERRYDTVRNAYDAGIPVFVG
                     TDAGGALAHGLAGAEVAELVTAGIPPVEALSATTWAARRWLGRPGLDEGAPADLVVFDR
                     DPRADVRVLTDPRRVVLNGRVVG"
     gene            1527..2654
                     /locus_tag="L6J92_RS25895"
                     /old_locus_tag="L6J92_25895"
     CDS             1527..2654
                     /NRPS_PKS="Domain: Aminotran_5 (53-299). E-value: 4.1e-29.
                     Score: 93.6. Matches aSDomain:
                     nrpspksdomains_L6J92_RS25895_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976957.1"
                     /locus_tag="L6J92_RS25895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_25895"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_224297931.1"
                     /sec_met_domain="Aminotran_5 (E-value: 4.7e-22, bitscore:
                     77.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLAPLGAGRFAAIEDRVARLLGTGQDVVVMQGEALLPLE
                     GAIRAAAGPGTVALNVVTGPYGQTFGDWLRDCGATVHDLAVPFHTAVSAGQVREALAAH
                     PETDFVSLVHAEAATGNTNPVGEIGEVVRAHGALFYLDAVASVGAEPVLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWARMAANPGAPRRSYLSLLDWKERWIDGGRKALLHAP
                     AQLEMLALEACVERIEAEGPETVMARHAAAAAATRAGALALGGLEPYVYEAKDAAPVAT
                     TLRTPSDVDASALVARALESDPALPLAAGGGALAGEMIRVNHYGRDATRGAVHGSLAAL
                     GAALAEKGLKADPEAARRAADRAWDGQGGAVLSGD"
     aSDomain        1686..2423
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L6J92_RS25895_Aminotran_5.1"
                     /evalue="4.10E-29"
                     /label="L6J92_RS25895_Aminotran_5.1"
                     /locus_tag="L6J92_RS25895"
                     /protein_end="299"
                     /protein_start="53"
                     /score="93.6"
                     /tool="antismash"
                     /translation="PGTVALNVVTGPYGQTFGDWLRDCGATVHDLAVPFHTAVSAGQVR
                     EALAAHPETDFVSLVHAEAATGNTNPVGEIGEVVRAHGALFYLDAVASVGAEPVLPDAW
                     GVDLCVIGAQKAMGGPAGVSAVSVSERAWARMAANPGAPRRSYLSLLDWKERWIDGGRK
                     ALLHAPAQLEMLALEACVERIEAEGPETVMARHAAAAAATRAGALALGGLEPYVYEAKD
                     AAPVATTLRTPSDVDASALVARAL"
     misc_feature    complement(2685..2698)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.14"
                     /tool="antismash"
     misc_feature    complement(2728..2744)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.39"
                     /tool="antismash"
     misc_feature    2801..2818
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.57"
                     /tool="antismash"
     misc_feature    complement(2803..2818)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    2813..2828
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    2874..2890
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.88"
                     /tool="antismash"
     misc_feature    2947..2959
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.5"
                     /tool="antismash"
     misc_feature    complement(2959..2974)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.79"
                     /tool="antismash"
     gene            2984..3496
                     /gene="ectA"
                     /locus_tag="L6J92_RS25900"
                     /old_locus_tag="L6J92_25900"
     CDS             2984..3496
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448158.1"
                     /locus_tag="L6J92_RS25900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_25900"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_031046591.1"
                     /transl_table=11
                     /translation="MTAAQADLQIDRPRVADGAALWRIARDSKVLDLNSSYSYLLWCRD
                     FAATSAVARDGHGVPVGFITGYVRPDRPDTLLVWQVAVDEAHRGRRLAASMLDGLAART
                     VTELGLTTLETTVSPDNTASQRLFASFAERHGARLEREVLFDTGLFPDGPHEPEVLHRI
                     GPLSAAG"
     gene            3628..4899
                     /gene="ectB"
                     /locus_tag="L6J92_RS25905"
                     /old_locus_tag="L6J92_25905"
     CDS             3628..4899
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (29-366). E-value: 6.1e-72.
                     Score: 234.4. Matches aSDomain:
                     nrpspksdomains_L6J92_RS25905_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="L6J92_RS25905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_25905"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_031046586.1"
                     /sec_met_domain="Aminotran_3 (E-value: 4.3e-77, bitscore:
                     258.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETVESEVRSYCRGWPTVFDRALGSRMYDEDGHEY
                     LDFFAGAGSLNYGHNNAVLKRALIDYLERDGVTHGLDMSTTAKRRFLETFQNIILRKRD
                     LPYKVMFPGPTGTNAVEAALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVEDFMWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARV
                     EWLRALADLCERQDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGMPMA
                     LTLFKPELDVWEPGEHNGTFRGNNPAFVTATATLETYWADGSAMEKQTRKRGEQVEQHM
                     IAITEENLADIKEYRGRGLVWGLEFHDKDRAGRVAKRAFELGLLIETSGPESEVVKLLP
                     ALTITPEELDEGMKTLARAVRETA"
     aSDomain        3715..4725
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L6J92_RS25905_Aminotran_3.1"
                     /evalue="6.10E-72"
                     /label="L6J92_RS25905_Aminotran_3.1"
                     /locus_tag="L6J92_RS25905"
                     /protein_end="366"
                     /protein_start="29"
                     /score="234.4"
                     /tool="antismash"
                     /translation="DRALGSRMYDEDGHEYLDFFAGAGSLNYGHNNAVLKRALIDYLER
                     DGVTHGLDMSTTAKRRFLETFQNIILRKRDLPYKVMFPGPTGTNAVEAALKLARKVKGR
                     ESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVEDFMWFERL
                     LEDQGSGLNKPAAVIVETVQGEGGINVARVEWLRALADLCERQDMLLIVDDIQMGCGRT
                     GAFFSFEEAGITPDIVTVSKSISGYGMPMALTLFKPELDVWEPGEHNGTFRGNNPAFVT
                     ATATLETYWADGSAMEKQTRKRGEQVEQHMIAITEENLADIKEYRGRGLVWGLEFH"
     gene            5001..5399
                     /locus_tag="L6J92_RS25910"
                     /old_locus_tag="L6J92_25910"
     CDS             5001..5399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010037840.1"
                     /locus_tag="L6J92_RS25910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_25910"
                     /product="ectoine synthase"
                     /protein_id="WP_037770517.1"
                     /sec_met_domain="ectoine_synt (E-value: 2.5e-52, bitscore:
                     174.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKELEGTDRHVKSASGTWETKRIVLAKEKVGFSLHETILY
                     AGMETEMWYANHIEAVVCTKGDAELTDRETGKKYHITPGTMYLLNGHERHTLKVNEEFH
                     CICVFNPPVTGREDHDENGVYPLLTEEV"
     gene            5406..6302
                     /gene="thpD"
                     /locus_tag="L6J92_RS25915"
                     /old_locus_tag="L6J92_25915"
     CDS             5406..6302
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448161.1"
                     /locus_tag="L6J92_RS25915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_25915"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_194278192.1"
                     /sec_met_domain="PhyH (E-value: 1.1e-40, bitscore: 138.9,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTNVTDLYPTRGATEVATPRQDPVVWGSPDTPGPVSQGDLQA
                     LDRDGFLAIDQLIGPDEVEVYQRELERLTTDPAIREDERSIVEPQSKEIRSVFEVHRIS
                     EVFAKLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLAN
                     MRTISVSIALTENYDTNGGLMIMPGSHKTFLGCAGATPKDNYKKSLQMQDAGIPSDEAL
                     TKMASEYGVKLFTGKAGSATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFSA
                     PIRRPEFIGARDFTPVR"
     gene            complement(6460..7554)
                     /locus_tag="L6J92_RS25920"
                     /old_locus_tag="L6J92_25920"
     CDS             complement(6460..7554)
                     /NRPS_PKS="Domain: Aminotran_5 (28-358). E-value: 4.2e-25.
                     Score: 80.3. Matches aSDomain:
                     nrpspksdomains_L6J92_RS25920_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448151.1"
                     /locus_tag="L6J92_RS25920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_25920"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_194278191.1"
                     /sec_met_domain="Aminotran_5 (E-value: 3.2e-19, bitscore:
                     67.8, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGEVPGPHSGAMESFENLVRAEFAPKTTYLNTASTGLLPARTLV
                     AMRDAAARAAEGQPLDMFADVEAARAAYARLMGVPATRVATGSSVATFSGLVAASLPEG
                     AEVLTAEADFASLVNPLYTRGGLKVRSVPLDRLAESVGPDTALVAVSSVQSADGRLADL
                     PALRDAARAHGARTLIDVSQSNGWLPTAADDFDYVAAVAYKWVLCPRGVAFLVVPEDLG
                     AAAGLRPLFAGWASGEHPWDSCYGPVEELAHSARRFDESPALFSYTGARQSLDLIGELG
                     VDAVHAHDTGLADRFRAGVRSLGHEPVPAPGSAIVSVPGLGHRQGVLSSAGVQVSDRAG
                     NLRAAFHVYNTAADVDRLLDVLAG"
     aSDomain        complement(6481..7470)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L6J92_RS25920_Aminotran_5.1"
                     /evalue="4.20E-25"
                     /label="L6J92_RS25920_Aminotran_5.1"
                     /locus_tag="L6J92_RS25920"
                     /protein_end="358"
                     /protein_start="28"
                     /score="80.3"
                     /tool="antismash"
                     /translation="TYLNTASTGLLPARTLVAMRDAAARAAEGQPLDMFADVEAARAAY
                     ARLMGVPATRVATGSSVATFSGLVAASLPEGAEVLTAEADFASLVNPLYTRGGLKVRSV
                     PLDRLAESVGPDTALVAVSSVQSADGRLADLPALRDAARAHGARTLIDVSQSNGWLPTA
                     ADDFDYVAAVAYKWVLCPRGVAFLVVPEDLGAAAGLRPLFAGWASGEHPWDSCYGPVEE
                     LAHSARRFDESPALFSYTGARQSLDLIGELGVDAVHAHDTGLADRFRAGVRSLGHEPVP
                     APGSAIVSVPGLGHRQGVLSSAGVQVSDRAGNLRAAFHVYNTAADVDRL"
     gene            complement(7630..8343)
                     /locus_tag="L6J92_RS25925"
                     /old_locus_tag="L6J92_25925"
     CDS             complement(7630..8343)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067467.1"
                     /locus_tag="L6J92_RS25925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_25925"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_243782177.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFDKALAAFPHRDGVEVVHRSFELDP
                     GRAKDDVQPVLTMLTAKYGMSEAQAQAGEDNLGAQATAEGLDYRTRDRDHGSTFDMHRL
                     LHLAKERNLHAELLDAFYRGNFADERSVFNDDERLVELSVAAGLDADEVRAVLADPAAH
                     ADAVRADEREAAQLGATGVPFFVLDRAYGVSGAQPAEVFTQALTQAWGERTPLKLIDDG
                     DAEACGPDGCAVPRS"
     gene            complement(8419..8922)
                     /locus_tag="L6J92_RS25930"
                     /old_locus_tag="L6J92_25930"
     CDS             complement(8419..8922)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329308.1"
                     /locus_tag="L6J92_RS25930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_25930"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_243782178.1"
                     /transl_table=11
                     /translation="MIDERATGRRVIRTVLPAEAGTLAALHHRARSTYYPDGLPEDGTD
                     WAAVWRTAVERPDGHVLCAVEHGRIVALASFRVPEGGGRDTVKLFQFHVDPGHWRSGIG
                     TALHTACVEQWRADGHRDAVLDVHVDNKRAQAFYARLGWLPDPHNPPAEGDHHLFLRFG
                     VLGE"
     misc_feature    complement(9494..9509)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     misc_feature    complement(9698..9713)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.08"
                     /tool="antismash"
ORIGIN
        1 gtggcgaggc ggcgtgcggg catgcggaag gtgttgccgt tcaaggtggt gggaccccca
       61 gtgagacatg cgtgtgggac acacatgagc gacgtgcttg ggacccggaa agaatctccc
      121 cgcgtacgcc ccaccgtcag cgatccggag tcacttcacc ccttcgtggg gttttggcgc
      181 atcctttcga atcccacggc acacgcgttc tcccagatca ctcgcgtcgg ctagccgacg
      241 acccgcccgt tcagcaccac ccggcgcgga tcggtgagca cgcgcacgtc ggcgcgcggg
      301 tcccggtcga acaccaccag gtccgccggc gcgccctcgt ccaggccggg gcgcccgagc
      361 cagcgccggg cggcccaggt cgtggcggag agcgcctcga cgggcgggat gccggcggtg
      421 accagctccg cgacctccgc gcccgccaga ccgtgggcga gggcgcctcc ggcgtcggtg
      481 ccgacgaaga ccgggatccc ggcgtcgtag gcgttgcgga cggtgtcgta gcggcgttcg
      541 tgcagccggc gcatgtgggc cgaccagcgc gggaagcggg actcgccgcc gtcggccagc
      601 gcggggaagg tggcgatgtt gacgagggtc ggcacgatgg cgacgccgcg ctcggcgaag
      661 agcgggatgg tgtcgtcggt cagccccgtg gcgtgttcga cgcagtcgat cccggcctcg
      721 accaggtcgc gcagggagtc ctcggcgaag cagtgcgcgg tgacccgggc gcccaggcgg
      781 tgggcctcgg cgatggccgc ctccacggcg ccgcgcggcc agcacgcgga caggtcgccg
      841 aggtcgcggt cgatccagtc gccgaccagc ttcacccagc cgtcgccgcg ccgggcctcc
      901 tgggcgacgt acgcgacgag gtcgtcgggc tctacctccc aggcgtagtt gcggatgtag
      961 cggcgggtgc gggcgatgtg ccggccggcc cggatgatct tcggcaggtc gtcgcggtcg
     1021 tcgatccagc gggtgtcaga gggcgagccc gcgtcgcgga ggagcagggt gcccgcctcg
     1081 cggtcggaca gggcctgctt ctcggcggcg tccgccggga ccgcgccgtg ccggtcgagg
     1141 ccgacgtggc agtgcgcgtc gaccaggccg ggcagcgccc acccctcgac ggtgcgcacg
     1201 tcggcggcgc cggcggggcg gtcgtaggag atccgcccgt cgatcaccca cacctcgtcc
     1261 cggacctcct cgggcccgac gagcacccgc cccttcacgt gcagcaccgc gcgatcagtc
     1321 atgcccgcac cctaacggtg cccgtacagg cgtccgggcg ggccgccggc cctcggcccg
     1381 gggccgttcc ggccgtagcg gaagctacga ttccgggcgt gggggtgtcg caacggaagg
     1441 gctccggcgt gagtgccggc ctgggccgtg gttactctcg ttccactacg tgtcgtccac
     1501 ctgcccgtga gtgaagagag ccccgcatga cccacccgtt cctggacctc gcaccgctgg
     1561 gcgccggccg tttcgccgcg atcgaggacc gggtcgcgcg gctgctcggc accgggcagg
     1621 acgtcgtggt catgcagggc gaggcgctgc tgccgctgga gggcgcgatc cgcgccgccg
     1681 ccggtccggg caccgtcgcg ctgaacgtcg tcaccggccc ctacgggcag acgttcggcg
     1741 actggctgcg ggactgcggg gcgaccgtgc acgacctcgc cgtgccgttc cacacggctg
     1801 tgagcgccgg gcaggtgcgg gaggcgctcg ccgcgcaccc ggagaccgac ttcgtgtccc
     1861 tggtgcacgc cgaggcggcg accgggaaca ccaacccggt cggggagatc ggcgaggtgg
     1921 tgcgggcgca cggcgcgctg ttctacctgg acgccgtggc ctccgtcggc gccgagccgg
     1981 tgctgccgga cgcgtggggc gtggacctgt gcgtcatcgg cgcgcagaag gcgatgggcg
     2041 gcccggccgg ggtgtcggcg gtgtcggtca gcgagcgggc gtgggcgcgg atggcggcga
     2101 acccgggcgc cccgcgccgg tcctacctct ccctcctcga ctggaaggag cgctggatcg
     2161 acggtggccg aaaagcgctg ctgcacgcgc cggcccagtt ggagatgctc gcactggagg
     2221 cctgcgtgga gcgcatcgag gcggagggcc cggagacggt gatggcgcgg cacgcggcgg
     2281 ccgcggcggc cacccgggcc ggcgcgctcg ccctgggcgg cctggagccg tacgtgtacg
     2341 aggcgaagga cgcggcgccg gtcgcgacga cgctgcggac cccctcggac gtcgacgcct
     2401 cggcactggt ggcccgggcc ctggagtcgg atccggcact gccgctggcc gccggcggag
     2461 gtgcgctggc cggggagatg atccgggtga accactacgg ccgggacgcc acgcgcgggg
     2521 cggtgcacgg ctccctggcg gcactgggtg ccgcgctggc ggagaagggc ctcaaggccg
     2581 atccggaggc cgcccggcgg gcggcggacc gggcatggga cggacagggc ggggcggttc
     2641 tttcgggaga ctgaattccc gggaattccc gaactataca caaactgaat taaagaatat
     2701 ggatcagcac aggttcccat attcttctgc ccgctttctc ttgacctaaa cacaaagatt
     2761 ccgcgaacct cgattctcgc atttcggaca cgtctcgcat cggttacgcg attgtgaccc
     2821 gatccacatg cggcccgctt cgcacctttt gaccggtaca aatcgccaca ttgcgcacac
     2881 ttctcgcgcg gtggcacgcg cccgcgtgat aacacaggac gcctgcatcc gtaaccccgt
     2941 cccgcgatgc aatttccaat ttccctgggt aaattcgatt tacatgactg ccgcgcaagc
     3001 agacctgcaa atcgatcgtc cgagagtggc cgacggcgcc gccctgtggc gcatagcgag
     3061 ggattccaag gtcctcgacc tgaactcgtc ctacagctat ctgctctggt gccgggactt
     3121 cgccgccacg tcggccgtcg cccgtgacgg gcacggcgtg ccggtcggct tcatcaccgg
     3181 ctacgtccgc ccggaccggc cggacaccct gctggtctgg caggtggcgg tggacgaggc
     3241 gcaccgcggg cgccggctcg ccgcctcgat gctcgacggg ctcgccgccc ggaccgtgac
     3301 ggagctcggg ctgaccaccc tcgagaccac cgtctccccc gacaacacgg cgtcccagcg
     3361 actgttcgcc tcgttcgccg agcggcacgg tgcccggctg gagcgcgagg tgctcttcga
     3421 caccggcctg ttcccggacg ggccgcacga accagaggtc ctccaccgca tcggccccct
     3481 gtccgcggcc ggctgacccg ccggccgccc ggacgccggg cacccccggc agtccggccc
     3541 ctcagacttc ccggccggga ccgcaccggt tccgccggac cgtacgacct tcctctgaca
     3601 ccctcaccca acgaggagcg attcgtcgtg accatcaccc agcccgacct cagcgtcttc
     3661 gagaccgtcg agtccgaggt gcgcagctac tgccgcggct ggcccaccgt cttcgaccgt
     3721 gcgctcggca gccgcatgta cgacgaggac ggccacgagt acctcgactt cttcgccgga
     3781 gcgggttcgc tcaactacgg gcacaacaac gccgtcctga aacgcgcgct gatcgactac
     3841 ctggagcggg acggcgtcac gcacgggctc gacatgtcga ccaccgccaa gcgccgcttc
     3901 ctggagacgt tccagaacat catcctgcgc aagcgcgacc tgccgtacaa ggtcatgttc
     3961 ccgggcccga cgggcaccaa cgccgtcgag gccgcgctga agctggcgcg caaggtcaag
     4021 ggccgcgagt cgatcgtgtc cttcaccaac gccttccacg gcatgtcgct gggctcgctg
     4081 gccgtgaccg gcaacgcgtt caagcgggcc ggcgccggca tcccgctggt gcacggcacg
     4141 cccatgccgt tcgacaacta cttcgacggc accgtcgagg acttcatgtg gttcgagcgg
     4201 ctgctcgagg accagggctc cggtctgaac aagccggccg ccgtgatcgt ggagaccgtg
     4261 cagggcgagg gcggcatcaa cgtcgcccgc gtcgagtggc tgcgcgccct ggccgacctg
     4321 tgcgagcgcc aggacatgct gctcatcgtg gacgacatcc agatgggctg cggccgtacc
     4381 ggcgccttct tctccttcga ggaggcgggc atcacgccgg acatcgtcac cgtctccaag
     4441 tcgatcagcg gctacggcat gccgatggcg ctgaccctgt tcaagcccga gctggacgtc
     4501 tgggagccgg gtgagcacaa cggcaccttc cgcggcaaca acccggcctt cgtcacggcg
     4561 accgccacgc tggagacgta ctgggccgac ggctcggcga tggagaagca gacccgcaag
     4621 cgcggtgagc aggtcgagca gcacatgatc gccatcaccg aggagaacct cgcggacatc
     4681 aaggagtacc ggggccgcgg cctggtctgg ggcctggagt tccacgacaa ggaccgcgcg
     4741 ggccgggtcg ccaaacgcgc cttcgagctc gggctgctca tcgagacgtc cggccccgag
     4801 agcgaggtcg tcaaactcct gccggcgctc accatcacgc ccgaagagct ggacgagggc
     4861 atgaagaccc tcgcccgggc cgtgcgcgag acggcctgac cgctccggca ccgccctccc
     4921 tgcttccggc gcctcgggcc tcgcggcccg gggcgccggg gaccatggca cacccttcac
     4981 ctaggaggca tcgcaacacc gtgatcgtcc gttcgttcaa ggaactggaa ggcaccgacc
     5041 gccacgtgaa gtcggcgtcg gggacctggg agaccaagcg catcgtcctc gccaaggaga
     5101 aggtcggctt ctccctgcac gagacgatcc tgtacgcggg tatggagacc gagatgtggt
     5161 acgcgaacca catcgaggcc gtcgtctgca cgaagggcga cgcggaattg accgaccgcg
     5221 aaacggggaa gaagtaccac atcacgcccg gcaccatgta cctcctgaac ggccatgagc
     5281 ggcacacgct caaggtcaac gaggagttcc actgcatctg cgtcttcaat ccccccgtga
     5341 ccggacggga ggaccacgac gagaacggcg tctacccgct gctcaccgag gaggtgtgag
     5401 tcaccgtgac cacgaccacg aacgtcactg acctctatcc cacccgcggc gccaccgagg
     5461 tggcaacccc ccggcaggac ccggtggtct ggggctcccc ggacacaccc ggtcccgtct
     5521 cccagggcga cctccaggcc ctggaccgcg acgggttcct cgccatcgac cagctcatcg
     5581 ggccggacga ggtcgaggtc taccagcggg agctggagcg gctcaccacc gacccggcca
     5641 tccgcgagga cgagcgctcg atcgtcgagc cgcagtccaa ggagatccgg tcggtcttcg
     5701 aggtgcacag gatcagcgag gtcttcgcga aacttgtgcg cgacgagcgc gtggtcgggc
     5761 gggcccggca gatcctcggc tcggacgtct acgtccacca gtcgcggatc aacgtcaagc
     5821 cgggcttcgg agccagcggc ttctactggc actcggactt cgagacctgg cacgccgagg
     5881 acggcctggc gaacatgcgt acgatctcgg tctcgatcgc actcaccgag aactacgaca
     5941 ccaacggcgg tctcatgatc atgccggggt cgcacaagac gttcctcggg tgcgcggggg
     6001 ccacgccgaa ggacaactac aagaagtcgc tgcagatgca ggacgcgggg atcccgtccg
     6061 acgaggcgct gacgaagatg gcgtcggagt acggcgtcaa gctgttcacc ggcaaggccg
     6121 gctcggcgac ctggttcgac tgcaactgca tgcacggttc gggcgacaac atcacgccgt
     6181 tcccgcgcag caacgtgttc atcgtgttca acagcgtgga gaacacggcg gtcgagccgt
     6241 tctcggcgcc gatcaggcga ccggagttca ttggggcgcg ggacttcact cccgtccggt
     6301 gacccggctc ggccgggggt ccgggggttg tcccccggat gtcgcagcat cgcggcgcgg
     6361 gacttcactc cggtgaagtg agccgcatct gatctcgggc aggggcctct tcgtgtggga
     6421 cgggaggctc ctgcccgatg ctgttccggg gctcttccct cagcccgcca gtacgtcgag
     6481 gagccggtcc acgtcggccg cggtgttgta cacgtggaag gcggcccgca ggttgcccgc
     6541 ccggtcggac acctggacgc cggcgctgct cagcacgccc tgccggtggc cgagccccgg
     6601 cacggacacg atcgcggaac ccggcgcggg caccggctcg tggcccagcg agcgcacccc
     6661 cgcgcggaag cggtcggcga gaccggtgtc gtgggcgtgc acggcgtcga cgcccagttc
     6721 cccgatcagg tccagggact gccgggcgcc ggtgtacgag aacagggcgg ggctctcgtc
     6781 gaagcgccgg gcggagtgcg cgagttcctc gacggggccg tagcagctgt cccaggggtg
     6841 ctcgcccgac gcccacccgg cgaacagcgg ccgcagcccg gccgccgctc ccagatcctc
     6901 cggtacgacg aggaaggcga cgccgcgcgg gcagagcacc cacttgtagg cgacggcggc
     6961 gacgtagtcg aagtcgtccg cggccgtcgg cagccagccg ttcgactggg acacgtcgat
     7021 cagggtccgc gccccgtgcg cgcgggcggc gtcccgcagc gcgggcaggt cggcgagccg
     7081 cccgtcggcc gactgcacgg agctgaccgc gacgagcgcg gtgtccgggc ccaccgactc
     7141 ggcgagccga tccagcggca cactgcgcac cttcaggccg ccgcgcgtgt acagggggtt
     7201 caccagcgag gcgaagtcgg cctcggcggt gaggacctcg gcgccctcgg gcagcgaggc
     7261 ggcgacgagc ccgctgaacg tggcgaccga cgagccggtc gcgacccggg tggcgggcac
     7321 ccccatgagg cgggcgtacg cggcccgggc cgcctcgacg tcggcgaaca tgtcgagcgg
     7381 ctgcccctcg gccgcacggg ccgccgcgtc acgcatggcg acgagggtcc gggcgggcag
     7441 caggccggta ctggcggtgt tcaggtacgt ggtcttcggg gcgaactcgg cgcggacgag
     7501 gttctcgaag ctctccatgg caccactgtg cggtcccggg acctccccgt ccattgcgta
     7561 tttcttagcg gtttccccaa gcaacgctta tgcacggccg ccgacctgcg gttccgaggg
     7621 gcggggccct cagctccggg gcaccgcaca cccgtcgggg ccgcaggcct ccgcgtcccc
     7681 gtcgtcgatc agcttgagcg gcgtccgctc gccccaggcc tgcgtcagcg cctgcgtgaa
     7741 gacctcggcg ggctgggcgc cggagacgcc gtaggcccgg tcgagcacga agaacggcac
     7801 gccggtggcc ccgagctgcg cggcctcgcg ctcgtcggcg cgcaccgcgt cggcgtgggc
     7861 ggcggggtcg gcgagcaccg cgcggacctc gtccgcgtcg agtccggcgg cgacggacag
     7921 ctccacgagc cgctcgtcgt cgttgaacac ggagcgctcg tcggcgaagt tgccccggta
     7981 gaaggcgtcc agcagttccg cgtgcaggtt ccgctccttg gccaggtgca gcagccggtg
     8041 catgtcgaag gtgctgccgt ggtcgcggtc ccgggtgcgg tagtcaaggc cctcggcggt
     8101 ggcctgcgcg ccgaggttgt cctcaccggc ctgcgcctgc gcctcgctca tgccgtactt
     8161 ggcggtgagc atcgtcagta ccggctgcac gtcgtccttg gcccggccgg ggtccagctc
     8221 gaaggaccgg tggaccacct cgacgccgtc ccggtgcggg aaggccgcga gcgccttatc
     8281 gaagcgggcc ttgcccacgt agcaccacgg gcaggcgatg tcgctccaga tctcgacgcg
     8341 catgtctcgg ctcttctcca ggtcgtaccg ctgcggaggc cctccccgcc tcgtgcgtga
     8401 acgttcaagc agccggtctc attccccgag cacgccgaac cgcaggaaga ggtggtggtc
     8461 gccctccgcg ggcgggttgt gcgggtcggg gagccagccg aggcgggcgt agaaggcctg
     8521 ggcacgcttg ttgtccacgt gcacgtcaag gaccgcgtcc cggtggccgt cggcccgcca
     8581 ctgctcgacg caggccgtgt gcagggcggt gccgatgccg gagcgccagt ggccggggtc
     8641 gacgtggaac tggaagagct tgacggtgtc gcgcccgcct ccctccggca cccggaagga
     8701 ggcgagggcg acgatgcgcc cgtgctccac ggcgcacagc acgtgtccgt cggggcgctc
     8761 gacggcggtg cgccacacgg ccgcccagtc ggtaccgtcc tcgggcagcc cgtccgggta
     8821 gtacgtcgac cgcgcccggt ggtgcagcgc ggcgagggtc ccggcctcgg cgggcagcac
     8881 ggtacggatc acccggcgcc cggtcgcacg ttcatcgatc atgcacacca ggacgcgcga
     8941 gcccggccgc gcggttgcgc gcagtcccgg tgggggaaat cgccccaggg gcgcggggaa
     9001 ctgcgcgaca ggccacgacg gcgagtcggc cgcagtacca ccgcacccct acggcgcgac
     9061 cgcgaaccgc taccgctcca gcaccccgtt gaaccgccgc ggcagcccga gggggttccc
     9121 gtcccgcacc tcgggcggca gcagcgcctc cggcaccccc tggtaggcca ccggccgcag
     9181 ccaccgctcg atcgccgtgc cgcccaccga cgtggacgtc gacgtggtcg ccgggtacgg
     9241 ccccccgtgg tgctgggccg ccgccacggc gacccccgtc ggccagccgt tcaccagcac
     9301 ccgcccggcc agcggcgtca cctcggcgag gacctcggcc ccgcgcccct cccccgccgc
     9361 ttccccggcg gagatctgca cggtcgccgt gaggttgccc ggcagccggg agagcacggc
     9421 ccgcacctcg tcggcgtcct ggtagcggac cacgacggtg accggcccga agcactcctc
     9481 cagaagcagg tcgtgctcgc cctcggcggc cagccgcgcg gccggcacgg tgaggaaccc
     9541 ggcggcgacg gtgtgctcgc cgcccgagcc gggcgtcacc ggcgagtcca cgtcgggcag
     9601 cgccacccgc tcggcgacgc cggccacgaa gttgtcccgc atgcggtggt cgaggaggac
     9661 accggcgtcg gtgtcgctga ccgcgtccgt gagggtcttg accagcccgt caccggcggc
     9721 gcccgcgggc acgaggacca ggccgggctt gacgcagaac tggccgacgc ccagggtcat
     9781 cgaaccggcc agccccgcgc cgatcgcgtc cgcccgctcg gcggcggcgg cctcggtgac
     9841 gacgaccggg ttcagcgagc ccagctcgcc gtggaagggg atcggcaccg gccgtgccgc
     9901 cgccgcgtcg aagagcgcgc ggcccccgcg tacggacccg gtgaagcccg ccgccgcgac
     9961 cagcgggtgc ttgaccagct cgacgcccgc ctcgaagccg tggacgaggc cgacgacgcc
    10021 ctcggggacg ccgtgccggg cggcggcgcg gcgcagcacc ttggcgacca gctcggacag
    10081 ggccgggtgg tcggggtggg ccttgacgac gaccgggcag ccggccgcga gggcgctcgc
    10141 ggtgtcgccg ccggggaccg agaaggcgaa ggggaagttg gacgccgagt agacggcgac
    10201 gacgccgagc ggcaccttgt agcggcgcag gtccgggatg ggcggggtgg cggtgtcgtc
    10261 ggggtggttg acgaccacgc cgaggaactc gccctcgtcg acgatgtcgg cgaaggcccg
    10321 cagttggtag ctggtgcggg cgagttcgcc ggtgaggcgg accgggccga gcgcggtctc
    10381 cgcgtcggcg acctcgacc
//
