LOCUS       NZ_CP094676            21137 bp    DNA     linear   CON 30-MAY-2024
DEFINITION  Streptomyces sp. CB09030 chromosome, complete genome.
ACCESSION   NZ_CP094676
VERSION     NZ_CP094676.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB09030
  ORGANISM  Streptomyces sp. CB09030
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Genomic of Streptomyces sp. CB09030
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2022) Xiangya International Academy of
            Translational Medicine, Central South University, Changsha, Hunan
            410013, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: Canu v. v1.5; Racon v. v3.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1510.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022827705.1-RS_2024_05_30
            Annotation Date                   :: 05/30/2024 05:11:20
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,205
            CDSs (total)                      :: 7,118
            Genes (coding)                    :: 7,015
            CDSs (with protein)               :: 7,015
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 40 of 103
            Pseudo Genes (incomplete)         :: 75 of 103
            Pseudo Genes (internal stop)      :: 10 of 103
            Pseudo Genes (multiple problems)  :: 21 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:41:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4802523
            Orig. end                         :: 4823660
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094676.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21137
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="29"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21137
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21137
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11137](-)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11137)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     misc_feature    complement(166..186)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            333..896
                     /locus_tag="L6J92_RS20100"
                     /old_locus_tag="L6J92_20100"
     CDS             333..896
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031691.1"
                     /locus_tag="L6J92_RS20100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20100"
                     /product="TerB family tellurite resistance protein"
                     /protein_id="WP_031032661.1"
                     /transl_table=11
                     /translation="MAMWDKIKDQAKTFQQSQGTRGASGSGQGAQASGRPGSSGGSKTQ
                     LIGMFKSQLASVKTELKSGSYRDASMAMCALVAAADGHVEPAERTRVEELIVSNEVLQN
                     FPADQLRQRFNQHVDRLLANVEQGRSEALQVIAKASKKPEEARAVIQTGMVVAGADGVF
                     EPSEQQAIREACSALGISPAEFGV"
     gene            complement(972..2411)
                     /locus_tag="L6J92_RS20105"
                     /old_locus_tag="L6J92_20105"
     CDS             complement(972..2411)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128726.1"
                     /locus_tag="L6J92_RS20105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20105"
                     /product="hypothetical protein"
                     /protein_id="WP_243783088.1"
                     /transl_table=11
                     /translation="MHRRSRPAVVAAALAAVFLGTLGNVSAAPARAAVEPTAGQPVAAD
                     CPPALAEKATCYTGQDENGAYYTMAVPHRWNGSLVVHAHGGPDLGDTSDPARSTEDLGR
                     WAVMVDEGYAWAGSSYRRGGYGARMAAADTENVRRLFTDRFGRPERTYLHGQSWGGNVA
                     AKVAETYGGRPGAYDGVLLTNGVLGGGSRGYDYRVDLRVVYQYYCHNHPRPTEPQYPLW
                     QGLRAGSTMTTAGLRARLQECTGYASDPADRTGPQQRNLDDILAVTGIPERTLESHLRF
                     ATFTFRDIVANRLDGRNPWSNRGVRYTGSHDDKALNAGVERFSADPTARRDLSYDSDLT
                     GKVSLPVLTMHAIDDPTAFVEHEAAYRATLRGAGRGGNLVQTFTKEHEHSSLSDSEYAN
                     SMAALDTWVSTGRRPSPRAIAASCAAFDATYGDGCFYDPGFRPAPYASRVLPRPGGLTW
                     PAMTAARERAWSSIQGVGIAP"
     gene            complement(2687..3793)
                     /gene="paaE"
                     /locus_tag="L6J92_RS20110"
                     /old_locus_tag="L6J92_20110"
     CDS             complement(2687..3793)
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaE"
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388024.1"
                     /locus_tag="L6J92_RS20110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20110"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaE"
                     /protein_id="WP_243781777.1"
                     /transl_table=11
                     /translation="MAPTAPVPAAPARARRRPAFHRLRVAAVERLCADAVAVRFEVPDE
                     LAGAYAFAPGQSLTLRREVDGRDERRSYSICAAAGSAPRIGVRVVPGGLFSAWLVDEVR
                     PGDTVEVMTPTGLFTPDLTVPGHHVLIAAGSGITPMVSIAESVLAADDRSTVTLFYGNR
                     RTGTVMFADELADLKDLHPARFQLAHVLSREPREAELLSGRLDAERLTALVGSLVEVEA
                     AGHWWLCGPQGMVADAQQVLAGLGVPADRVHRELFFAGDEPVREVHHEEGGPRGPVSEV
                     TVTLDGRSTTASLSRERSILDGAQQTRPDLPFACKGGVCGTCRALVTDGKADMRRNYAL
                     EAAEVDAGYVLTCQSYPVSEQLTVDYDS"
     gene            complement(3793..4308)
                     /gene="paaD"
                     /locus_tag="L6J92_RS20115"
                     /old_locus_tag="L6J92_20115"
     CDS             complement(3793..4308)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388025.1"
                     /locus_tag="L6J92_RS20115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20115"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaD"
                     /protein_id="WP_194279017.1"
                     /transl_table=11
                     /translation="MVTAGPALPDAHRARRVAERVPDPELPMLTLADLGVLRDVETRAD
                     GTVVASLTPTYSGCPAMAEMRADVAARLRAAGYARVEIRTVLDPPWTSDWITESGRRKL
                     AEHGIAPPGRAPRGPVPLLLSPTRPAVPCPRCGSRETEETSRFAATSCKALWRCRACRE
                     PFEYVKEI"
     gene            complement(4302..5129)
                     /gene="paaC"
                     /locus_tag="L6J92_RS20120"
                     /old_locus_tag="L6J92_20120"
     CDS             complement(4302..5129)
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326306.1"
                     /locus_tag="L6J92_RS20120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20120"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaC"
                     /protein_id="WP_243781778.1"
                     /transl_table=11
                     /translation="MSDDHVYLTLAEGHEDDTRWAYGTGFEDPLHGVDTTVPEGVDAAG
                     LAAECVALADDALVGAQRLAEWITRAPELEEEVALANIGLDLLGQARLLYTRAGQADGT
                     GRDEDAYAYFRDAADFRNVTLAELPGGDFAFTVVRLLVLSSWRLAHFRGLVDHPDPVLA
                     AVAAKGVKELTYHRQYAAQWCVRLGDGTDESHRRMRAALEQVAPYLGELHTAHDVRDEV
                     AADLRQVTDAAGLPLPVYRPLPGSGRAGEHTEHLAPLLTELQGIARAHPEATW"
     misc_feature    5136..5150
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.93"
                     /tool="antismash"
     gene            complement(5139..5441)
                     /gene="paaB"
                     /locus_tag="L6J92_RS20125"
                     /old_locus_tag="L6J92_20125"
     CDS             complement(5139..5441)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988149.1"
                     /locus_tag="L6J92_RS20125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20125"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaB"
                     /protein_id="WP_195887697.1"
                     /transl_table=11
                     /translation="MSADRPERQGWPLYEVFVRGKRGLNHVHVGSLHAADDAMALTHAR
                     DLYTRRNEGVSIWVVRSEHIAASTRDEKDPFFAPSADKVYRHPTFYDIPDDVPHI"
     gene            complement(5438..6424)
                     /gene="paaA"
                     /locus_tag="L6J92_RS20130"
                     /old_locus_tag="L6J92_20130"
     CDS             complement(5438..6424)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003132.1"
                     /locus_tag="L6J92_RS20130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20130"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaA"
                     /protein_id="WP_243781779.1"
                     /transl_table=11
                     /translation="MTMTHAAEAPPPQEPGGLQEHFDATVARDQRVEPRDWMPDGYRKT
                     LIRQIAQHAHSEIIGMQPEGEWITRAPSLRRKAILFAKVQDEAGHGLYLYSAAETLGAD
                     RDDLTERLIEGRQKYSSIFNYPTLSFADVGVIGWFVDGAAICNQVPLCRSSYGPYARAM
                     VRICKEESFHQRQGYELLMTMMRGTPAQREMVQDAVDRWWWPSLMMFGPPDDASPNSAR
                     SMAWKIKRHSNDELRRRFVDMTVPQAEKLGVTLPDPELRWNEEAGHHDFGTPDWDELTR
                     VIKGDGPCNAQRTERRRTAHEEGAWVREAATAHAAKQAARTQKGAAV"
     misc_feature    6443..6456
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.77"
                     /tool="antismash"
     misc_feature    6563..6578
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.17"
                     /tool="antismash"
     gene            6603..7172
                     /gene="paaI"
                     /locus_tag="L6J92_RS20135"
                     /old_locus_tag="L6J92_20135"
     CDS             6603..7172
                     /EC_number="3.1.2.-"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031682.1"
                     /locus_tag="L6J92_RS20135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20135"
                     /product="hydroxyphenylacetyl-CoA thioesterase PaaI"
                     /protein_id="WP_308027093.1"
                     /transl_table=11
                     /translation="MVGEVSQAAEQTPAEVMFAADRASRGLGIELVEQGAGSAVVRMTV
                     TPAMVNGHRIAHGGFLFLLADTAFACACNSHGPVTVAAGADIVFVAPAREGDVLVARAE
                     ERARYGRSGIYDVSVRRGDEVIAEFRGRSRSARGDGVGPRARDDGNGHHARDDEDGHDA
                     RRDEITHRAREGAARGTPGTTTKESR"
     gene            7169..8515
                     /gene="paaK"
                     /locus_tag="L6J92_RS20140"
                     /old_locus_tag="L6J92_20140"
     CDS             7169..8515
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (109-352). E-value: 2.7e-19.
                     Score: 60.9. Matches aSDomain:
                     nrpspksdomains_L6J92_RS20140_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971673.1"
                     /locus_tag="L6J92_RS20140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20140"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_243781780.1"
                     /sec_met_domain="AMP-binding (E-value: 8.1e-25, bitscore:
                     85.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSEPTTGAAPATRRGEPLPHDLLDDAERLSSEQLQELQLDRLRA
                     TLRHAYDNVELYRKKFDAAGVVPDDCRSLADLSRFPFTTKADLRETYPFGMFAVPMAAV
                     RRVHASSGTTGRATVVGYTDNDLSAWADVVARSIRAAGGRPGHKVHVSYGYGLFTGGLG
                     AHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPSYMLTLLDEFERQGVDPRTT
                     SLQVGIFGAEPWTEEMRREIEERAGIHAVDIYGLSEVMGPGVAQECVETKDGLHVWEDH
                     FYPEVVDPLTDAVLPGGEEGELVFTSLTKEALPVVRYRTRDLSRLLPGTARPAFRRMSK
                     VTGRCDDMIILRGVNVFPTQIEEIVLRTPGVAPHFQIRLTARGRMDHLTVRVEARPDAG
                     PEQREAAARAIGQSVKDGVGVSVEVEIVDPETLERSLGKLHRVKDLRTA"
     aSDomain        7496..8224
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L6J92_RS20140_AMP-binding.1"
                     /evalue="2.70E-19"
                     /label="L6J92_RS20140_AMP-binding.1"
                     /locus_tag="L6J92_RS20140"
                     /protein_end="352"
                     /protein_start="109"
                     /score="60.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="SSGTTGRATVVGYTDNDLSAWADVVARSIRAAGGRPGHKVHVSYG
                     YGLFTGGLGAHYGAERAGCTVIPASGGMTARQVQIIQDFRPEIIMVTPSYMLTLLDEFE
                     RQGVDPRTTSLQVGIFGAEPWTEEMRREIEERAGIHAVDIYGLSEVMGPGVAQECVETK
                     DGLHVWEDHFYPEVVDPLTDAVLPGGEEGELVFTSLTKEALPVVRYRTRDLSRLLPGTA
                     RPAFRRMSKVTGRCDDMIILR"
     CDS_motif       8192..8254
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_L6J92_RS20140_0001"
                     /evalue="2.60E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="L6J92_RS20140"
                     /protein_end="362"
                     /protein_start="341"
                     /score="13.8"
                     /tool="antismash"
                     /translation="TGRCDDMIILRGVNVFPTQIE"
     gene            8625..9923
                     /locus_tag="L6J92_RS20145"
                     /old_locus_tag="L6J92_20145"
     CDS             8625..9923
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMO-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971674.1"
                     /locus_tag="L6J92_RS20145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20145"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_224293427.1"
                     /sec_met_domain="FMO-like (E-value: 1.3e-78, bitscore:
                     263.4, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.3e-10, bitscore:
                     38.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVCVIGAGLSGLAVAHALKERGIPFVCLEKAPDVGGIWRQPGAG
                     ERGPGYLSLHLNTAKQLTGYADFPMPSSYPLYPRHSQFAAYLRSFAEWAGLLGHVELRT
                     EAVSVRQDADGGWTVVSRDADGAETSRRFEQVVVASGHHTDPALPDPLPAGADSFTGTI
                     LHSLDYRDGGDFDGRRVVVVGLGASAVDIAADLSRHAEQTLLSVRRGLHIVPKQLFGMS
                     VDEIAEAPWWTEMSFAEQRRWVERALLVARGRLGDYGLPEPDHPVFSSATTLSDEILSR
                     IRHGAVTPKPAIGSFDGDRVVFTDGTSVTADAVVYCTGFRMTFPFLPAGCPVAADGSVE
                     LYRRVVPADRPGLYFVGLVRPVGSITRLVEAQAQWVARLVDGEAELPAAGEMREEIATY
                     LAGIVQRYGRAPGASVQVDVGPYLAEFRESLPV"
     gene            complement(10001..11137)
                     /locus_tag="L6J92_RS20150"
                     /old_locus_tag="L6J92_20150"
     CDS             complement(10001..11137)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971675.1"
                     /locus_tag="L6J92_RS20150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20150"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_243781781.1"
                     /sec_met_domain="indole_PTase (E-value: 3.3e-143, bitscore:
                     475.7, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAPTGADLRGTPTLGALTGGQLRRLAAVAGLSATDTAAYVRVL
                     ADSLGPVAARPLSLPPPTRTFLSDDHTPVEYSLSFRPDAAPALRVLLEPGCGADSLARN
                     GRVGLEAVRRMARRWHFATDALDEIEDLFLPSGPQGPLALWCALELRPGGVPGVKVYLN
                     PAANGAERSAATVREALHRLGHRRAFAALPHGAGYPFLALDLGEWAQPRVKVYVRHDNL
                     TAGRAGRLSRTDWGPGPAAIEGFFRAAAALGPDVAGLGRRPALSCHSFTDTAAVRPSGF
                     TLHIPVRDYVRHDGEALARAARVLRHHGMDPSVLVRALAAVTARRLEDGAGLVAYLALA
                     HQQGHPPRVTAYLSAEAYAVRPAVGGSAPTAMPAMPVG"
     misc_feature    11133..11148
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     misc_feature    complement(11263..11276)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.73"
                     /tool="antismash"
     gene            complement(11345..12691)
                     /locus_tag="L6J92_RS20155"
                     /old_locus_tag="L6J92_20155"
     CDS             complement(11345..12691)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972616.1"
                     /locus_tag="L6J92_RS20155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20155"
                     /product="cytochrome P450"
                     /protein_id="WP_194279010.1"
                     /transl_table=11
                     /translation="MNAHDPAPVPPPGCPAHGSGARVPLHGPEFAADPQAYYEYLRHYG
                     AAAPVELAPGVEATLVTDYTAALQLLQDSGSFRKDARRWRAFNEGKVSPDSPVAPLLAY
                     RPNCMFADGADHLRLRQAVTDSMARVDTRRLSRSTEQISRYLISQFAARGSADLLGDYA
                     KQLPLFVFNELFGCPADIGDRVLFGISGMFDGVNAEKATEVLFQAVGELVALKREKPGD
                     DVTSWLMRHEAGLDDEEMVHQLALLLGAGAEPLRNLIGNTLHRLLTHERYAREGGLIDE
                     ALDDTLWENPPMSNYAPHYPAADTEFAGQQLQAGDLVLVSFAAANTGPALKASRQAGSN
                     RAHLAWSAGPHACPSKEPARHITVTAIEHLLNELPDVALAVPEDSLAWRPGPFNRALAT
                     LPARFTPVRSVRRTEPRPAPAAEQEKAAAPARPAERAGMWSQFLNWLTR"
     misc_feature    complement(12684..12695)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     gene            complement(12707..13297)
                     /locus_tag="L6J92_RS20160"
                     /old_locus_tag="L6J92_20160"
     CDS             complement(12707..13297)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005331.1"
                     /locus_tag="L6J92_RS20160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20160"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_037770300.1"
                     /transl_table=11
                     /translation="MGSAPSLDERDYVREGATQTAVKILVVGHFAVGKTTLIGSISEIE
                     PLSTEETMTQAAEPVDDLKGVKGKTTTTVAMDFGRLTISDRIVLYLFGTPGQQRFVQMW
                     EDMARGALGALVLVDPERLADSFPVIDLIEHYGLDYAIAVNHFDGAPARDERALREALD
                     LLDDTPVVTCDARDEKSSAAALTTLVRHLLDRA"
     gene            complement(13272..13649)
                     /locus_tag="L6J92_RS20165"
                     /old_locus_tag="L6J92_20165"
     CDS             complement(13272..13649)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971677.1"
                     /locus_tag="L6J92_RS20165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20165"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_194279009.1"
                     /transl_table=11
                     /translation="MTGRDGWTPESAALVRPYVITKGRNLPDEDALSLLTLVTASAEDA
                     RRPARLSPEEQSLLDLCSAGYLSVAEIAGHTHFPLGVVRILLASLMEGGYLLTRPPVAR
                     ARLADREILEEVLNGLRAKFG"
     misc_feature    complement(13608..13610)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13646..14047)
                     /locus_tag="L6J92_RS20170"
                     /old_locus_tag="L6J92_20170"
     CDS             complement(13646..14047)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971678.1"
                     /locus_tag="L6J92_RS20170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20170"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_031032694.1"
                     /transl_table=11
                     /translation="MNDDLSWMLDSALEIPGALHAVLISADGLLMARTQDFDKDDADRV
                     AAAMSGVQSLSRTLSFFCEDPGQNWRQTLVEFDGGWVFLISAGEGAYLGVSASPEVDMA
                     DITFRMQQLVAQLGKRLTTPPRENLGARS"
     gene            complement(14044..15225)
                     /locus_tag="L6J92_RS20175"
                     /old_locus_tag="L6J92_20175"
     CDS             complement(14044..15225)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971679.1"
                     /locus_tag="L6J92_RS20175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20175"
                     /product="ATP-binding protein"
                     /protein_id="WP_037770293.1"
                     /transl_table=11
                     /translation="MTEYTANPLLWVLLVALVAAAVLVSRQRRAARALRQQVQGLRDRY
                     TQLENNYGKSVQAAQERAEDETKTVLKSAMRTLQGLAAEQQLVLSRLQSKYGESALLED
                     LLEIDHTNSQFGRRAQSVAVLCDGWLGGRRDTASVYDVVRSAQGRIRHFRRVDILSRVD
                     FGITSRAVEPVALALAELLDNATSYSSPDTVVEINIRTVPKGICVVVDDAGVGMSDEER
                     ARADKLLATERASGVAALGNPPQFGFAVIGLLCERFGFEVSVDSSSPYGGVRAVVLLPH
                     DMLTAMPEKKAPAPADRPTARPVPDGGPEAAPAASRTDDGLPRRRRKRPMAIVPGSASA
                     PRPAGRSDSEQARVMGAFQRGTRSGRGTEPENAENADRTSSTPGASSEGHEVS"
     misc_feature    complement(15411..15420)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.82"
                     /tool="antismash"
     gene            15558..16310
                     /locus_tag="L6J92_RS20180"
                     /old_locus_tag="L6J92_20180"
     CDS             15558..16310
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324211.1"
                     /locus_tag="L6J92_RS20180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20180"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_194962956.1"
                     /transl_table=11
                     /translation="MAAVFAAGVGAGAINSVVGSGTLITFPVLLATGLSPVTATVSNAL
                     GLIPGSISGAIGYRKELTGQRRRVLKLGAGALLGGLAGATLLLSLPPDAFETIVPVLVG
                     LALVLVAFQPQIGRLVQRRRERTGASPRRDGGPLLLVGLTLASVYGGYFTAAQGIIYLS
                     LMGMLLDEPMQRLNGVKNVLSAVVNTVAALFFLFAADFDWTAVGLLAVGSALGGWFGAK
                     VGRRFSPLVLRILVVTVGTVALAQLLLR"
     misc_feature    16427..16442
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.79"
                     /tool="antismash"
     gene            16491..17849
                     /locus_tag="L6J92_RS20185"
                     /old_locus_tag="L6J92_20185"
     CDS             16491..17849
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016639923.1"
                     /locus_tag="L6J92_RS20185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20185"
                     /product="cytochrome P450"
                     /protein_id="WP_194279006.1"
                     /sec_met_domain="p450 (E-value: 1.6e-77, bitscore: 259.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVAPPPIPRAAGSLPFLGHAVQLMRDNLGFVAALRTTYGPLVE
                     ITLQPGTRTLVVQDPGLIRTMLTDLGPSLDKGRFFEKMGQLLGDSVVTAAGQVHVRKRR
                     QLQPAFAREQIARYVDTMRAETDAAVDDWVPGRPLDVREAMVGLSLNMLAKTIFSGSLD
                     DATFRRLRADLSIVMNGVGARVMLPDWVERLPLPANRRFNSARDGVRATIERAVSDLQD
                     SGHDTGDMLSLLLRTTDEETGEPLTGHQISSEILTLAVAGTETTASVLSWMLYELARNP
                     EIGARVLEELDEVLGDRPVAFDDLGRLPYLGRVVEETLRMHHTGWLVTRRTVTETRLGP
                     WTVPPGTELAYCQHALHRDPLLFRDPLEFDPDRWLDDPGPRPTQGFLPFGAGKHKCIGD
                     RFAFTELVTAVATIVRRVRLELAPGQTVRPVAAATVRPRTLLMTVREKEGQGA"
     misc_feature    17926..17944
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.64"
                     /tool="antismash"
     gene            17985..18821
                     /locus_tag="L6J92_RS20190"
                     /old_locus_tag="L6J92_20190"
     CDS             17985..18821
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324209.1"
                     /locus_tag="L6J92_RS20190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20190"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_195887703.1"
                     /transl_table=11
                     /translation="MTGRTASSPTPDHDDAVLRLQDVSVRRLTTDQLILDGVDWSVRPG
                     EHWALLGANGAGKTTLLRLLGALMHPTTGTVEVLGSRLGRVDVRELRARIGHVNSAQRV
                     PQDLTAHAVVLTGHSGTVQPLWRTYDDEVRERARGLLTELGVKELADRPYGVCSGGQRA
                     RILIARALMADPALLLLDEPFNALDLPSREDLVEAMHQLTEGRPRLATVTVTHHLEELF
                     PAVSHTLLLREGRILSRGPVDDVLTDDLLTACFGREITVARRDGRWSAYSGRRTRG"
     gene            complement(19048..19413)
                     /locus_tag="L6J92_RS20195"
                     /old_locus_tag="L6J92_20195"
     CDS             complement(19048..19413)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992805.1"
                     /locus_tag="L6J92_RS20195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20195"
                     /product="transglycosylase family protein"
                     /protein_id="WP_243781782.1"
                     /transl_table=11
                     /translation="MICRRNALQGNVRRPHGRTIRTAVAALLAAAALAATTGAAASPSV
                     SLRTDWDSIAACESGGDWQANTGNGYYGGLQFAPSSWAAAGGLKYAPRADLATRAEQIA
                     VAKRLAGLQGMSAWGCA"
     gene            complement(19516..20985)
                     /locus_tag="L6J92_RS20200"
                     /old_locus_tag="L6J92_20200"
     CDS             complement(19516..20985)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324207.1"
                     /locus_tag="L6J92_RS20200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_20200"
                     /product="sialate:H+ symport family MFS transporter"
                     /protein_id="WP_195887704.1"
                     /transl_table=11
                     /translation="MSSARTTAKPRPWYREITRQKWKSFFAAWIGYLLDGFDFVLITLV
                     LTEIADDFGLSTVESASLVSGAFITRWLGGAVLGALGDRFGRRSAMVASILLYSVGTFA
                     CGFAWDYTSLFTARLLIGMGMAGEYSASATYVLESWPARLRNRASGFLISGFSLGGVLA
                     AEVYEHVVPGHGWRWLFYIGLFPVVVALWVRRSLPEADDWEARVGATGERPNPFRPLFA
                     GRRRASVNTVLAVVATGSLFAVFTPLGAGAVPVLSVVATACLAAFAVQLGGRRRWLLFV
                     ALCATVFCAFLYSWPVQALLPTYLKTELGFTPAQVSDALYYAGFGTMAGCIVTGFVGDR
                     FGTRRAYACTLAVGIAFVFPVFAIRDSQLQLGILLFLMLACMQGISGLLPKYIAGHFPT
                     ETRAASLGFTYNVGALGGAVAPVLGARLASSMSLGQSLAVLTFSLTLVVILLIGFDVPS
                     RLNRLVDPEAVPDYLATEAAADGAPSVPSAK"
ORIGIN
        1 gggggccacc acaggcgcag cgcccagtac agcagcgcct gacccgcggt cgacacgacg
       61 ccgatcgcga cgaaccagcc gacctgccgc gaccacaccg tacgctcccg cccggccgcc
      121 ggttcggcgg cctctgtcgg cgcagcctac tccgccccca tcagcctctt tgccttttct
      181 ttgcctttag ggaaccctgt ggtgccacgg cccgttcatc ctggtggctg cggaaacccc
      241 gcgggagacc gcgggttggg accgggccgg aacgcacgac ggccggacgc acaacagcca
      301 gacgcacaac aacagaagcc gaggtggcac gagtggcgat gtgggacaag atcaaggacc
      361 aggccaagac cttccagcag tcccagggca ctcggggagc gagcggatcc ggccagggcg
      421 cgcaggcgag cggccggccg ggttcctccg gaggctccaa gacgcagctg atcgggatgt
      481 tcaagtccca gctcgcgtcg gtcaagaccg agttgaagag cggctcctac cgggacgcca
      541 gcatggccat gtgcgcgctg gtcgccgcgg ccgacgggca cgtggaaccg gcggagcgca
      601 cgcgcgtgga ggagctgatc gtctccaacg aggtgctgca gaacttcccc gcggaccagc
      661 tccgtcagcg gttcaaccag cacgtggacc ggctcctcgc caacgtcgag cagggcagga
      721 gcgaggccct gcaggtgatc gccaaggcgt cgaagaagcc cgaggaggct cgtgccgtca
      781 tccagaccgg catggtcgtc gccggggccg acggggtctt cgagccctcc gagcagcagg
      841 cgatccgcga ggcctgctcc gccctgggca tctcgcccgc ggagttcggc gtctgacaca
      901 ccactaggtc cgcccggcgc actcgacgtg ccgggcggac cgggcggacc gggcggaccg
      961 gaccggaccg gctagggagc gatccccacg ccctggatgc tgctccacgc ccgctcccgc
     1021 gcggcggtca tggcgggcca ggtgaggccg cccggccggg gcagcacccg cgaggcgtac
     1081 ggcgcggggc ggaaaccggg gtcgtagaag cagccgtcgc cgtacgtcgc gtcgaaggcg
     1141 gcgcaggagg ccgcgatcgc acgcgggctc ggccgccggc cggtgctgac ccaggtgtcc
     1201 agcgcggcca tggagttggc gtactcggag tcgctcagcg agctgtgctc gtgctccttc
     1261 gtgaacgtct ggacgaggtt cccgccccgt cccgcgcccc gcagggtggc gcggtaggcc
     1321 gcctcgtgct ccacgaaggc cgtcgggtcg tcgatggcgt gcatcgtgag gacggggagg
     1381 gacaccttgc cggtgaggtc gctgtcgtag gacaggtcac ggcgcgcggt ggggtcggcc
     1441 gagaagcgtt cgacgcccgc gttgagcgcc ttgtcgtcgt gcgagccggt gtagcgcaca
     1501 ccccggttgc tccacgggtt ccgcccgtcg agccggttgg ccacgatgtc ccggaacgtg
     1561 aaggtggcga accgcagatg cgactccagg gtgcgctcgg gaatgcccgt gacggcgagg
     1621 atgtcgtcga ggttgcgctg ctgcggcccg gtccggtcgg ccgggtccga ggcgtaaccc
     1681 gtgcactcct ggaggcgggc gcgcagcccg gcggtcgtca tcgtggagcc ggcccgcagc
     1741 ccctgccaca gggggtactg cggctcggtc gggcgcgggt ggttgtggca gtagtactgg
     1801 tagaccaccc gcaggtcgac gcggtagtcg tagccgcgcg aaccgccgcc gagtacgccg
     1861 ttggtcagca gcaccccgtc gtaggcgccg gggcgcccgc cgtacgtctc ggcgaccttg
     1921 gccgcgacgt tgccgcccca ggactggccg tgcaggtagg tccgctccgg gcggccgaac
     1981 cggtcggtga acaggcgccg cacgttctcg gtgtcggcgg ccgccatgcg ggccccgtaa
     2041 ccgccgcgcc ggtaggagga acccgcccag gcgtacccct cgtcgaccat caccgcccag
     2101 cgtcccaggt cctcggtgct gcgggcgggg tcggaggtgt cgccgaggtc ggggccgccg
     2161 tgggcgtgca cgacgaggga gccgttccag cggtggggca cggccatcgt gtagtaggcc
     2221 ccgttctcgt cctgcccggt gtagcaggtg gccttctcgg cgagggcggg cgggcagtcg
     2281 gcggccaccg gctgcccggc cgtcggctcc acggccgccc gggcgggggc ggcggagacg
     2341 ttgccgaggg tgccgaggaa cacggccgcc agcgcggcgg ccaccaccgc ggggcggctt
     2401 ctgcggtgca tggccccggt ggcatgcgtg ggagcgtcgg gtgtggtcaa ggtgcggctc
     2461 ctgtacgtgc tgcgtgcggg cgcgattttg cgctgcgagc cgggatgtta ggaaccgtcc
     2521 ggagccgggg ccagcctttg gatcattgcg ttcatagtgt tcgcccgtcc cggcggcggc
     2581 cggccgggac gggcgtgcgc tcggcagtcg tgccactggg cggtcgtcgt ctccgcggtc
     2641 gtgcgctcgg cagtcgtccg cgctgctgtg ggccgctcgc gcggcctcag ctgtcgtagt
     2701 ccacggtcag ctgctcggag accgggtagg actggcaggt cagcacgtaa ccggcgtcga
     2761 cctcggccgc ctccagggcg tagttgcggc gcatgtcggc cttgccgtcg gtgaccaggg
     2821 cgcggcaggt gccgcacacg ccgcccttgc aggcgaaggg gaggtcgggc cgggtctgct
     2881 gggcaccgtc gaggatgctc cgctcccggg agagggaggc ggtggtggag cggccgtcca
     2941 gggtgacggt gacctcgctg accggccccc gggggccacc ctcctcgtgg tggacctcgc
     3001 gcacgggctc gtcgccggcg aagaacagct cgcggtggac gcggtccgcg ggcacgccga
     3061 ggccggccag gacctgctgg gcgtcggcga ccatgccctg cggcccgcac agccaccagt
     3121 ggccggcggc ctccacctcc accagggagc cgaccagcgc ggtcagccgc tcggcgtcca
     3181 ggcggccgga gagcagctcg gcctcgcgcg gttcgcggga gaggacgtgg gcgagctgga
     3241 agcgggccgg gtggaggtcc ttcaggtcgg ccagttcgtc ggcgaacatc accgtgccgg
     3301 tgcggcggtt gccgtagaag agggtgacgg tggagcggtc gtcggcggcg agcaccgact
     3361 cggcgatgga caccatcggc gtgatgcccg aaccggccgc gatcagcacg tggtggcccg
     3421 ggacggtcag gtcgggcgtg aagaggccgg tgggcgtcat cacctcgacg gtgtcgcccg
     3481 ggcgcacctc gtccaccagc caggcggaga acaggccgcc cggcaccacc cgcaccccga
     3541 tgcggggagc cgaaccggcc gccgcgcaga tcgagtagga acggcgctcg tcccggccgt
     3601 cgacctcgcg ccgcagggtg agcgactgtc cgggcgcgaa ggcatacgcc ccggcgagct
     3661 cgtccgggac ctcgaagcgc acggccaccg cgtccgcgca cagccgctcc acggccgcga
     3721 cgcgcaggcg gtggaaggcg gggcggcggc gggcgcgtgc gggggccgcc ggtacggggg
     3781 cggtcggggc catcagatct ccttgacgta ctcgaacggc tcgcggcagg cccggcagcg
     3841 ccacagtgcc ttgcaggagg tggcggcgaa gcgcgaggtc tcctcggtct cccgcgaccc
     3901 gcagcggggg cagggcaccg cgggccgggt gggcgacagc agcagcggga ccgggccgcg
     3961 gggagcgcgg ccgggcgggg cgatgccgtg ctcggcgagc ttgcggcggc cggactccgt
     4021 gatccagtcg ctggtccagg gcgggtccag gacggtgcgg atctccacgc gcgcgtaccc
     4081 cgccgcgcgc agccgtgcgg cgacgtccgc gcgcatctcc gccatggccg gacaccccga
     4141 gtaggtgggg gtcaggctcg cgaccacggt gccgtccgcc cgcgtctcga cgtcgcgcag
     4201 gacgcccagg tcggcgaggg tcagcatggg cagctcgggg tccggcacgc gctcggcgac
     4261 gcgccgggcg cggtgggcgt ccgggagggc ggggccggcg gtcaccatgt cgcctccggg
     4321 tgggcgcggg cgatgccctg caactcggtg agcagcggcg ccagatgctc ggtgtgctcg
     4381 cccgcgcggc cggagccggg cagcgggcgg tagaccggca ggggcagtcc ggcggcatcg
     4441 gtgacctggc gcaggtcggc ggcgacctcg tcccgcacgt cgtgggccgt gtgcagttcg
     4501 ccgaggtagg gggcgacctg ctccagcgcc gcccgcatcc ggcggtgcga ctcgtccgtg
     4561 ccgtcgccca ggcgtacgca ccactgggcg gcgtactgcc ggtggtaggt cagctccttg
     4621 acgcccttgg cggcgaccgc cgcgaggacc gggtccgggt ggtccaccag cccccggaag
     4681 tgcgccaggc gccagctgga gagcaccagc agccgtacga cggtgaacgc gaagtcgccg
     4741 ccgggcagtt ccgccagcgt cacgttgcgg aagtcggcgg cgtcgcggaa gtaggcgtag
     4801 gcgtcctcgt cgcggccggt gccgtcggcc tgcccggcgc gggtgtagag caggcgggcc
     4861 tggccgagga ggtcgaggcc gatgttggcc agcgccacct cctcctccag ctcgggcgca
     4921 cgggtgatcc actcggcgag ccgctgggcg ccgacgaggg cgtcgtcggc cagcgccacg
     4981 cactccgcgg ccagtccggc ggcgtcgacg ccctcgggca cggtggtgtc gacgccgtgc
     5041 agcgggtcct cgaaaccggt gccgtaggcc cagcgggtgt cgtcctcgtg tccctcggcc
     5101 agggtgaggt agacgtggtc gtcgctcatg ccctgctcct agatgtgggg gacgtcgtcg
     5161 gggatgtcgt agaaggtcgg gtgccggtag accttgtcgg cgctgggggc gaagaagggg
     5221 tccttctcgt cgcgggtgga ggcggcgatg tgctcggagc gcaccaccca gatgctcacg
     5281 ccctcgttgc gccgggtgta gaggtcgcgt gcgtgggtga gggccatggc gtcgtcggcg
     5341 gcgtgcagcg agccgacatg gacgtggttg aggccgcgct tgccgcgcac gaacacctcg
     5401 tacagcggcc agccctgccg ctcgggccgg tcggcgctca taccgccgct cccttctgcg
     5461 tgcgggccgc ctgcttggcg gcgtgggcgg tggccgcctc gcgcacccag gcgccctcct
     5521 cgtgcgcggt gcgccgtcgc tccgtgcgct gggcgttgca cggcccgtcg cccttgatga
     5581 cgcgcgtcag ctcgtcccag tcgggggtgc cgaagtcgtg gtgccccgcc tcctcgttcc
     5641 agcgcagctc ggggtcgggc agggtgacgc cgagcttctc cgcctgcggg accgtcatgt
     5701 cgacgaagcg ccggcgcagt tcgtcgttgc tgtgccgctt gatcttccag gccatcgacc
     5761 gcgccgagtt gggtgaggcg tcgtcgggcg ggccgaacat catcagtgag ggccaccacc
     5821 agcggtccac ggcgtcctgg accatctcgc gctgcgccgg ggtgccgcgc atcatcgtca
     5881 tcagcagctc gtagccctgc cgctggtgga aggactcctc cttgcagatg cgcaccatcg
     5941 cgcgcgcgta cggcccgtag gaactgcggc acagcggcac ctggttgcag atcgcggcgc
     6001 cgtccacgaa ccagccgatc acgccgacgt cggcgaagct cagggtcggg tagttgaaga
     6061 tcgacgagta cttctggcgc ccctcgatca gccgctcggt gaggtcgtcg cggtccgcgc
     6121 cgagggtctc ggccgccgag tacagataga gcccgtggcc ggcctcgtcc tggaccttgg
     6181 cgaacaggat cgccttgcgg cgcagtgacg gggcccgcgt gatccactcg ccctcgggct
     6241 gcatgccgat gatctccgag tgcgcgtgct gggcgatctg ccggatcagc gtcttccggt
     6301 agccgtccgg catccagtcg cgcggttcga cgcgctggtc gcgcgcgacg gtcgcgtcga
     6361 agtgctcctg gagtccgccc ggctcctgcg ggggcggtgc ctcggcggcg tgtgtcatgg
     6421 tcatcgtcac cagcttccca accgaccatt cgttcggtat cagtgtgacg ggtttccggt
     6481 cgccgggcaa gaccccggaa ccccgccgcc cgcacccttg acagggcgag cggccggctg
     6541 gattactggg ccgtgccgca agctgaccga atggtcggtc ggggtaccgg ccgggataca
     6601 gggtggtggg agaggtgtcg caggccgccg agcagacgcc cgcggaggtg atgttcgccg
     6661 cggaccgggc ttcccgcggg ctgggcatcg agctggtgga gcagggcgcg ggatccgcgg
     6721 tggtccggat gaccgtgacc ccggcgatgg tcaacggcca ccggatcgcc cacggcggct
     6781 tcctgttcct gctggccgac accgcgttcg cctgcgcgtg caacagccac ggccccgtga
     6841 ccgtcgcggc cggcgccgac atcgtcttcg tcgccccggc ccgcgagggc gacgtgctcg
     6901 tggcccgcgc cgaggagcgt gcccgctacg ggcgcagtgg gatctacgac gtgagcgtgc
     6961 ggcgcggcga cgaggtgatc gcggagttcc gcggccgcag ccgcagcgcg cggggcgacg
     7021 gggtcggtcc ccgcgcccgg gacgacggaa acggccacca cgcgcgcgac gacgaggacg
     7081 gccacgacgc gcggcgcgac gagatcacgc accgcgcgcg ggagggcgcg gcgcgcggga
     7141 cgccgggcac gacgacgaag gagtcgcgat gagcagcgag ccgacgaccg gggccgcccc
     7201 ggcaacccga cggggcgagc ccctccccca cgacctgctc gacgacgccg agcgcctctc
     7261 ctccgagcag ctccaggagc tccagctcga ccggctgcgg gcgaccctgc ggcacgcgta
     7321 cgacaacgtg gagctgtacc gcaagaagtt cgacgccgcc ggggtcgtgc cggacgactg
     7381 ccgcagcctg gcggacctgt cgcggttccc cttcaccacc aaggccgacc tgcgggagac
     7441 ctaccccttc gggatgttcg ccgttccgat ggccgccgta cggcgcgtgc acgcctccag
     7501 cggcaccacc ggccgcgcca ccgtggtcgg atacacggac aacgacctgt cggcgtgggc
     7561 ggacgtcgtc gcccgctcga tccgggccgc cggcggccgg cccggccaca aggtgcacgt
     7621 ctcctacggc tacggcctgt tcaccggcgg cctcggcgcg cactacggcg ccgaacgcgc
     7681 cggttgcacc gtgatccccg cctccggcgg gatgacggca cgccaggtgc agatcatcca
     7741 ggacttccgg cccgagatca tcatggtcac gccgtcctac atgctcaccc tgctcgacga
     7801 gttcgaacgg cagggcgtcg acccgcgcac cacctccctc caggtcggca tcttcggcgc
     7861 ggagccgtgg accgaggaga tgcggcgcga gatcgaggag cgggcgggca tccacgccgt
     7921 cgacatctac ggcctgtccg aggtgatggg cccgggcgtg gcccaggagt gcgtcgagac
     7981 caaggacgga ctgcacgtgt gggaggacca cttctacccc gaggtggtcg acccgctcac
     8041 ggacgccgta ctgcccgggg gcgaggaggg ggagctcgtc ttcacctccc tgaccaagga
     8101 ggcgctgccc gtcgtccgct accgcacgcg cgacctgtca cggctgctgc cgggcaccgc
     8161 ccgccccgcc ttccggcgga tgagcaaggt caccggccgc tgcgacgaca tgatcatcct
     8221 gcgcggcgtg aacgtcttcc ccacccagat cgaggagatc gtgctgcgca cgcccggcgt
     8281 cgccccgcac ttccagatcc ggctcaccgc acgcggccgc atggaccacc tgaccgtacg
     8341 cgtggaggcc cgcccggacg cgggtcccga gcagcgcgag gccgccgccc gggcgatcgg
     8401 acagagcgtc aaggacggtg tgggcgtgag cgtggaggtg gagatcgtgg acccggagac
     8461 gctggagcgc tccctgggca aactccaccg ggtcaaggac ctgcgcacgg cgtgaaacgt
     8521 gaggacggac acgcctgttc gctcctcggt ccggtgtgcg agtcggtacg gatgggcagg
     8581 aagtccatga tcgggggagg tttgagcttt ctggggggaa tcccgtgcgc gtgtgtgtga
     8641 tcggtgcagg cctgtcgggg ctggcggtgg cgcacgccct caaggagcgc ggcatcccgt
     8701 tcgtctgcct ggagaaggcg ccggacgtcg gcgggatctg gcgtcagccg ggggccggcg
     8761 agcgggggcc gggctatctg tcgctgcacc tcaacaccgc caagcagctg accggttacg
     8821 cggacttccc gatgccgtcc tcgtatccgc tctacccccg gcacagccag ttcgccgcct
     8881 acctgcgctc cttcgccgag tgggccggcc tgctcggcca cgtcgagctg cgcaccgagg
     8941 cggtctcggt gcgccaggac gcggacggcg ggtggacggt cgtcagccgg gacgcggacg
     9001 gcgccgagac ctcgcgccgg ttcgagcagg tggtcgtcgc ctccggccac cacaccgacc
     9061 cggccctgcc cgaccccctg ccggccggcg ccgactcctt caccggaacg attctgcact
     9121 cgctcgacta ccgcgacggc ggcgacttcg acggccgccg cgtcgtcgtg gtgggcctcg
     9181 gcgcgtcggc ggtggacatc gcggcggacc tctcccggca cgccgagcag accctgctgt
     9241 cggtgcggcg cgggctgcac atcgtgccca agcagctctt cgggatgtcg gtcgacgaga
     9301 tcgccgaggc cccgtggtgg accgagatgt ccttcgccga gcagcgccgg tgggtggagc
     9361 gggccctgct cgtcgcccgc ggcagactcg gggactacgg tctgcccgag ccggaccacc
     9421 cggtgttctc gtccgcgacc accctctcgg acgagatcct cagccggatc cggcacggcg
     9481 ccgtgacgcc gaagcccgcg atcggctcgt tcgacggcga ccgggtcgtc ttcaccgacg
     9541 gcacctccgt gaccgcggac gcggtcgtct actgcaccgg cttccgcatg accttcccct
     9601 tcctgccggc gggctgcccg gtggcggcgg acggctcggt cgagctgtac cgcagggtcg
     9661 tcccggccga ccgtccgggt ctgtacttcg tgggtctggt ccgcccggtg ggctcgatca
     9721 cccggctggt ggaggcccag gcccagtggg tggcgcgact cgtcgacggc gaggcggaac
     9781 tgccggccgc cggggagatg cgcgaggaga tcgccacgta cctcgccggc atcgtccagc
     9841 ggtacggccg ggcgccgggc gcctccgtcc aggtcgacgt gggtccgtac ctggcggagt
     9901 tccgggagtc cctgcccgtg tagcgggacc gcggcgcgct tcaccgctcg ggctcccggt
     9961 ggcgtccacc gggagccctg ccgtgtccgg acgggcccgc tcagcccacc ggcatcgccg
    10021 gcatcgccgt gggagcgctc ccgccgaccg cgggcctgac cgcgtacgcc tccgcggaga
    10081 ggtaagcggt cacccgcggc gggtggccct gctggtgggc cagcgccagg taggcgacga
    10141 gtcccgcgcc gtcctcgagg cgccgtgcgg tgacggcggc cagggcgcgg acgaggaccg
    10201 aggggtccat gccgtggtgc cgcagcacgc gcgccgcccg cgcgagggcc tccccgtcgt
    10261 ggcggacgta gtcccggacg gggatgtgca gggtgaagcc gctcggccgg acggcggcgg
    10321 tgtcggtgaa ggagtggcag gacagggcgg gccgccggcc gaggcccgcc acgtcgggac
    10381 cgagggccgc ggcggcgcgg aagaacccct cgatcgcggc gggccccggg ccccagtccg
    10441 ttcgggacag ccgcccggcc cgccccgccg tgaggttgtc gtgccgcacg tagaccttca
    10501 cccggggctg cgcccactcc cccaggtcca gggcgaggaa cgggtacccg gcaccatggg
    10561 gcagggcggc gaaggcccgc cggtggccga gccggtgcag cgcctcgcgc accgtcgcgg
    10621 cggaacgttc cgccccgttg gccgccgggt tcagatagac cttgacgccg ggtacaccgc
    10681 cgggtctgag ctccagcgcg caccacaggg ccagcggccc ctggggaccg gagggcagga
    10741 acaggtcctc gatctcgtcc agtgcgtcgg tggcgaagtg ccagcgtcgc gccatccgcc
    10801 gcaccgcctc cagtccgacg cggccgttgc gggccaggct gtctgcgccg cagcccggtt
    10861 ccaggagcac ccgcagggcg ggcgccgcgt cgggccggaa ggagagggag tactcgacgg
    10921 gggtgtggtc gtcggagagg aaggtacggg tgggcggggg cagactcaac ggccgtgcgg
    10981 ccaccgggcc cagcgagtcg gccagcaccc ggacgtaggc cgcggtgtcc gtcgcggaga
    11041 gtcctgcgac ggccgcgagc cttcgcaact gcccgcccgt gagggccccg agcgtcggtg
    11101 tgccccgcag atcggcgccc gtcggtgcgg cggtcaccgg cccgtccccg gtcggagccg
    11161 gacaaagcga tacccgcctg gcgaggcggg tatcggggtt ctctgcggcc ggaaagcggc
    11221 gttcgtggat atgtggtcca cgacacctcc ttttactcgt aagcaacttg aatgccgcgt
    11281 tgctcactac ccgtgccgtt caaacttcat gcgaggggtg cgggttgggg agatgttgcg
    11341 gaggtcaccg cgtgagccag ttgaggaact ggctccacat gcctgcgcgc tcggccggac
    11401 gggccggggc ggccgccttc tcctgctcgg ccgccggagc cgggcggggc tcggtgcgcc
    11461 gcacggagcg gacgggggtg aacctggccg ggagcgtggc cagggcccgg ttgaaggggc
    11521 ccggacgcca ggccaggctg tcctcgggga cggcgagcgc gacgtcgggc agttcgttga
    11581 gcaggtgctc gatggccgtg acggtgatgt gccgggccgg ctccttggag gggcaggcgt
    11641 gcggacccgc gctccaggcc aggtgggccc ggttgctgcc ggcctggcgc gaggccttga
    11701 gggccggccc ggtgttggcc gcggcgaagc tcaccaggac gaggtcgccc gcctggagct
    11761 gctgaccggc gaactccgtg tcggcggccg ggtagtgcgg ggcgtagttg gacatcggcg
    11821 ggttctccca cagcgtgtcg tcgagcgcct cgtcgatcag gcctccctca cgggcgtacc
    11881 gctcgtgggt caggagccgg tgcagggtgt tgccgatgag gttgcgcagg ggttcggcgc
    11941 ccgcgccgag gagcagggcg agctggtgga ccatctcctc gtcgtcgagc cccgcctcgt
    12001 ggcgcatcag ccaggaggtg acgtcgtcac cgggcttctc ccgcttgagc gccacgagtt
    12061 ccccgaccgc ctggaagagc acctcggtgg ccttctcggc gttcactccg tcgaacatgc
    12121 cggagatgcc gaacagtacc cggtccccga tgtcggcggg gcagccgaag agttcgttga
    12181 acacgaacag cggcagctgc ttggcgtagt ccccgagcag gtcggcggag ccgcgggcgg
    12241 cgaactgcga gatgaggtag cgggagatct gctcggtgct ccggctcagc cgccgggtgt
    12301 cgacccgcgc catgctgtcg gtgacggcct ggcggagcct gaggtggtcg gcgccgtcgg
    12361 cgaacatgca gttgggccgg tacgcgagca ggggcgcgac cgggctgtcc gggctcacct
    12421 tgccctcgtt gaaggcccgc cagcggcggg cgtccttgcg gaacgagccg gagtcctgca
    12481 gcagctggag cgccgccgtg tagtccgtga ccagcgtggc ctcgacgccg ggggccagct
    12541 cgacgggggc cgcggccccg tagtggcgca ggtactcgta gtacgcctgc gggtcggcgg
    12601 cgaactccgg tccgtgcaac ggcacccggg cgccggatcc gtgggccggg cagccgggcg
    12661 gcggcaccgg cgcggggtcg tgggcgttca tgtctgcttc cggctcctag gctctgtcga
    12721 gcagatggcg gacgagggtg gtcagtgcgg cggccgagga cttctcgtcg cgggcgtcgc
    12781 aggtgacgac gggggtgtcg tcgagcaggt cgagcgcctc gcgcagcgcc cgttcgtcgc
    12841 gcgccggcgc gccgtcgaag tggttgacgg cgatggcgta gtcgagtccg tagtgctcga
    12901 tgaggtcgat caccgggaag gagtccgcga gccgctcggg gtcgaccagg acgagggcgc
    12961 cgagcgcgcc gcgggccatg tcctcccaca tctgcacgaa acgctgctgg ccgggggtgc
    13021 cgaacaggta gagcacgatg cggtcgctga tggtgaggcg gccgaagtcc atggcgaccg
    13081 tggtggtggt cttgcccttc acacccttga ggtcgtcgac cggctcggcg gcctgcgtca
    13141 tcgtctcctc ggtggacagc ggctcgatct cggagatgga gccgatgagg gtggtcttgc
    13201 ccaccgcgaa gtgtccgacg acgaggatct tgaccgcggt ctgggtcgct ccctcgcgca
    13261 cgtagtcccg ctcatccaaa cttggcgcgg agcccattga gcacctcctc caggatctcc
    13321 ctgtccgcga ggcgggcgcg ggccaccggc ggacgggtca ggaggtaccc gccctccatc
    13381 agggacgcca gcaggatccg caccacgccc agcgggaagt gggtgtgccc ggcgatctcg
    13441 gcgaccgaga ggtagccggc ggaacacagg tcgagcaggc tctgctcctc gggggagagc
    13501 cgggcgggcc gccgcgcgtc ctcggcggac gcggtgacca gggtgaggag cgagagggcg
    13561 tcctcgtcgg gcaggttgcg gcccttggtg atgacgtacg gacgtactaa tgcggcggac
    13621 tcgggcgtcc agccgtcgcg gccggtcatg agcgggcgcc gaggttctcg cgcggcggtg
    13681 tcgtcagccg cttgccgagc tgggcgacga gttgctgcat gcggaaggtg atgtcggcca
    13741 tgtccacctc cggggaggcg gagacgccga ggtaggcgcc ctcgccggcg gagatcagga
    13801 agacccagcc gccgtcgaac tcgacgaggg tctggcgcca gttctggccc gggtcctcac
    13861 agaagaagga gagggtgcgg ctgagcgact gcacaccgct catcgcggcg gccacccggt
    13921 cggcgtcgtc cttgtcgaag tcctgcgtcc gggccatcag caggccgtcg gcggatatca
    13981 ggaccgcgtg cagggccccc ggaatctcca gggcgctgtc gagcatccat gacagatcgt
    14041 cgttcacgag acctcatgtc cttcactgct tgcaccaggt gtgctgctcg tccggtcggc
    14101 gttctcggcg ttctccggct cggtgccccg gccggagcgc gttccgcgct ggaaggcgcc
    14161 catgacccgg gcctgctcgg agtcggagcg tccggcgggg cgcggggcgg aggcgctgcc
    14221 gggcacgatg gccatcggcc gcttgcggcg ccgccggggc agaccgtcgt cggtccggga
    14281 ggcggcgggc gcggcctccg gtccgccgtc cgggaccggc cgggcggtgg ggcggtcggc
    14341 cggtgcgggc gccttcttct cgggcatggc ggtgagcatg tcgtgcggca gcagaaccac
    14401 cgcccgtacg cctccgtagg gagaggagga gtccaccgac acctcgaacc cgaagcgctc
    14461 gcacagcagg ccgatgacgg cgaagccgaa ctgcggcggg ttgccgagag ccgccacgcc
    14521 cgaggcgcgc tcggtggcga gcagcttgtc ggcgcgcgcc cgttcctcgt cgctcatgcc
    14581 gacgccggcg tcgtccacga ccacgcagat gcccttgggc acggtgcgga tgttgatctc
    14641 cacgacggtg tccgggctgg agtagctggt ggcgttgtcg agcagttcgg cgagggccag
    14701 cgcgacgggc tcgacggcgc ggctggtgat gccgaagtcg acccgggaga ggatgtccac
    14761 ccggcggaag tgccggatgc gtccctgcgc gctgcggacc acgtcgtaca ccgaggcggt
    14821 gtcgcgccgg ccgcccagcc agccgtcgca caggaccgcg acggactgcg cgcgccggcc
    14881 gaactgcgag ttggtgtggt cgatctccag caggtcctcg agcagggccg attcaccgta
    14941 cttgctctgc agccgggaga gcaccagctg ctgttcggcg gcgaggccct ggagagtccg
    15001 catggccgat ttcagcacgg tcttcgtctc gtcctcggcc cgctcctgag cggcctgcac
    15061 ggatttcccg tagttgttct ccagctgggt gtagcggtcc cggagcccct ggacctgctg
    15121 ccgcaacgcc cgggccgccc tgcgctggcg gctgacgagc acggcggcgg cgacgagggc
    15181 gacgagcagg acccagagca atgggtttgc cgtgtattcc gtcataagac tctcttcagg
    15241 cgacttacgg ccggtttgct gtgttccggt ccacgcgggc ggtccggcgg accgccggcg
    15301 cccgggtggc cgcccgggct gtccctgaag tcggggatgc cgtctttcac cgcacccgcc
    15361 cgctctgcaa acgcggtgat cgtatcaccg catgatcagg tgaattaacg tcaaagaacg
    15421 cccatcacgg accggttgag accgggggcc gggtccgccg gagcggtggg tacagtcggg
    15481 cccgtgaaag acgcacaagg cacgttccgg ctgagtacgg gcccggcgcg cggcggcacg
    15541 gggtgacgcc cgaggccatg gccgcggtct tcgcggcggg cgtcggagcc ggcgccatca
    15601 acagcgtcgt cggctccgga accctgatca ccttccccgt actgctggcc acgggactgt
    15661 cgccggtgac cgcgacggtg tccaacgcgc tgggtctgat ccccggctcc atcagcggtg
    15721 ccatcggcta ccgcaaggag ctgaccggcc agcgccggcg cgtcctgaag ctgggcgccg
    15781 gggccctgct cggcggcctg gcgggcgcca ccctgctgct gtcgctgccg ccggacgcct
    15841 tcgagacgat cgtgccggta ctggtgggcc tcgccctggt actggtggcg ttccagccgc
    15901 agatcggccg gctggtgcag cgccgccggg agcgcaccgg tgcctctccc cgccgggacg
    15961 gcggtccgct gctcctcgtc ggcctgaccc tcgccagcgt ctacggcggc tacttcaccg
    16021 ccgcccaggg gatcatctac ctgtccctga tgggcatgct cctcgacgaa cccatgcaac
    16081 gcctcaacgg cgtcaagaac gtcctctccg ccgtcgtcaa caccgtcgcc gccctcttct
    16141 tcctcttcgc cgcggacttc gactggaccg ccgtcggact gctcgcggtc ggctcggccc
    16201 tgggtggctg gttcggcgcc aaggtgggcc gacgtttcag ccccctggtt ctgcggatac
    16261 tggtggtgac ggtcggcacg gtcgccctgg cgcagctgct gctgcgctag ccaggggcca
    16321 ccggtgtcgg gggcggacgg gagtggaatc tgcccaaccg cctccccggc caatcatttc
    16381 cggccatccg ggacacgtgg gaaatgccac gttccgtggc cgattgacgt cggtagcgat
    16441 cagggaagcc atggagcgcc catgatcgat gcgaagggac agaccccacc gtgacgctcg
    16501 tagcgcctcc ccccataccc agggcagcgg gttcgctgcc gttcctgggc cacgcggtac
    16561 agctcatgcg cgacaacctc ggcttcgtcg ccgcgctgcg caccacctac ggccccctgg
    16621 tcgagatcac cctccagccc ggcacccgca ccctcgtcgt gcaggatccc ggcctcatcc
    16681 gcaccatgct gaccgacctg ggaccgagcc tcgacaaggg ccggttcttc gagaagatgg
    16741 gacagctcct cggcgactcc gtcgtcaccg cggccggcca ggtccacgtc cgcaagagac
    16801 gccagctgca acccgccttc gcccgcgagc agatcgcccg gtacgtcgac accatgcgcg
    16861 ccgagacgga cgccgccgtc gacgactggg tccccggccg gccgctggac gtccgcgagg
    16921 ccatggtcgg gctcagcctg aacatgctgg ccaagacgat cttctcgggc agtctcgacg
    16981 acgccacgtt ccgccggctg cgcgccgacc tgtcgatcgt gatgaacggc gtgggcgccc
    17041 gcgtcatgct gcccgactgg gtcgagcggc tcccgctgcc cgccaaccgc cgcttcaact
    17101 cggcgcgcga cggcgtgcgg gccaccatcg aacgcgccgt gagcgacctc caggactccg
    17161 gccacgacac cggtgacatg ctctcgctgc tgctgcgcac caccgacgag gagaccggag
    17221 agccgctgac cggccaccag atctcctccg agatcctcac cctggccgtc gccggcaccg
    17281 agaccaccgc ctcggtcctg tcctggatgc tgtacgaact cgcccgcaac ccggagatcg
    17341 gggcgcgggt cctggaggag ctcgacgagg tcctcggcga ccggccggtg gccttcgacg
    17401 acctcggccg gctgccgtac ctgggccggg tggtggagga gacgctgcgg atgcaccaca
    17461 ccgggtggct cgtcacccgg cgcaccgtca ccgagacccg gctcggcccc tggacggtgc
    17521 cccccggcac cgaactcgcc tactgtcagc acgccctgca ccgcgacccg ctgctgttcc
    17581 gcgacccgct ggagttcgac cccgaccgct ggctggacga cccggggccg cggcccactc
    17641 aagggttcct gcccttcggc gccggcaagc acaagtgcat cggcgaccgg ttcgcgttca
    17701 ccgaactcgt caccgccgtc gccaccatcg tgcggcgggt acggctggag ctcgcgcccg
    17761 gccagacggt gcgccccgtc gccgcggcca cggtccggcc ccgcaccctg ctgatgaccg
    17821 tccgcgagaa ggaggggcag ggggcatagg aagcagaggg gagaacaggg gagaagagag
    17881 cggcagcggc cgggcgtcca ggaaccggac ggtccggcag gcatgtggtg gatacatcta
    17941 ctgtgcacgg tgaccgagga cgtcccgtac gaaggagtca cggcatgacc ggccggaccg
    18001 ccagctcccc cacgcccgac cacgacgacg ccgtactccg gctccaggac gtgagcgtcc
    18061 gccgcctcac cacggaccag ctgatcctgg acggcgtcga ctggtcggtc cgcccgggcg
    18121 agcactgggc cctgctgggg gccaacggcg ccgggaagac gaccctgctg cggctgctcg
    18181 gcgcgctcat gcaccccacg accggcacgg tcgaggtgct cggcagccgg ctcggccggg
    18241 tcgacgtgcg ggagctgcgg gcgcgcatcg gccatgtgaa ctccgcccag cgggtgccgc
    18301 aggacctcac cgcgcacgcg gtcgtgctga ccggccacag cggcacggtc cagcctctgt
    18361 ggcggacgta cgacgacgag gtgcgggagc gggcccgcgg cctgctgacc gagctgggcg
    18421 tcaaggagct ggcggaccgg ccctacggcg tctgctcggg cggtcagcgg gcgcggatcc
    18481 tcatcgccag ggcgctgatg gccgacccgg cgctgctcct cctggacgag cccttcaacg
    18541 ccctggacct gccgtcccgg gaggacctcg tcgaggcgat gcaccagctg accgaggggc
    18601 gcccccggct ggccacggtg acggtcaccc accacctgga ggagctgttc ccggccgtca
    18661 gccacaccct gctgctgcgc gagggccgga tcctgtcccg ggggccggtg gacgacgtcc
    18721 tcacggacga cctgctgacc gcctgcttcg gccgcgagat cacggtcgcc aggcgcgacg
    18781 gccgctggtc ggcctactcc ggccggcgca cccggggtta gtcccaccac cgccgccgtc
    18841 cgaaagggcg gagcggtccc ggacgtgtcg gcgtgcggaa cgtccggggc cgcccctcgg
    18901 ctcccccgcc ggggactgcc caatcggcgc tccggacaaa cggaacgccc cggaggccgg
    18961 gcccggttca cgcccgcggg tgaccccggt caacacgcgt ccccgtcgag cgcggacccc
    19021 gcgcccggga cgtcccgggc cgtggtctca ggcgcagccc caggccgaca ttccctgcag
    19081 gccggccagg cgcttcgcga cggcgatctg ctcggcgcgg gtcgcgaggt ccgcgcgcgg
    19141 ggcgtacttc aggccgccgg ccgcggccca gctcgacggg gcgaactgca ggcccccgta
    19201 gtagccgttg ccggtgttcg cctgccagtc gccgcccgac tcgcaggcag cgatggagtc
    19261 ccagtccgtg cgcagcgaga ccgacgggga ggcggccgcc ccggtggtcg cggcgagtgc
    19321 ggccgcggcg aggagagcgg ccacggcggt ccggatcgtg cgaccgtgcg gacggcgcac
    19381 gttgccctga agagcatttc gtctacagat catacttgga ctgttacccc acgtgagggc
    19441 gggccgccgc cccgcccggc gccgccctac gccggtcgga gcacccgaac caccctgttc
    19501 gccgtggagt ccgcgtcact tcgccgacgg cacggacggc gcgccgtccg ccgccgcctc
    19561 cgtggcgagg tagtccggca cggcctccgg gtcgaccagc cggttgaggc ggctgggcac
    19621 gtcgaacccg atcagcagga tgaccacgag tgtcagcgag aaggtcagca ccgcaagcga
    19681 ctggccgagc gacatggaag aggccagcct ggccccgagc accggcgcga cggcgccgcc
    19741 cagcgcaccg acgttgtagg tgaagcccag ggacgcggcc cgggtctcgg tcgggaagtg
    19801 cccggcgatg tacttcggca gcagccccga gatgccctgc atgcaggcga gcatcaggaa
    19861 cagcaggata cccagctgca gttggctgtc gcggatcgcg aagacgggga agacgaaggc
    19921 gatcccgacc gccagcgtgc acgcgtacgc ccggcgggtg ccgaaccggt cgccgacgaa
    19981 cccggtgacg atgcagcccg ccatcgtgcc gaacccggca tagtagagcg cgtcgctgac
    20041 ctgggcgggg gtgaagccca gttcggtctt gaggtaggtg ggcagcaggg cctggaccgg
    20101 ccagctgtag aggaaggcgc agaacacggt ggcgcagagc gccacgaaca gcagccacct
    20161 cctgcgcccg cccagctgga ccgcgaaggc ggcgaggcag gccgtcgcca ccacggacag
    20221 gacgggcacc gcaccggcgc cgagcggggt gaacaccgcg aacagcgagc cggtggcgac
    20281 caccgccagc accgtgttga cgctcgcccg gcgccgcccc gcgaacagcg ggcggaaggg
    20341 gttgggccgc tcgccggtgg cccccacccg ggcctcccag tcgtcggcct cgggcagcga
    20401 ccgccgcacc cacagggcga cgaccaccgg gaacagcccg atgtagaaca gccagcgcca
    20461 gccgtgtccc ggcaccacgt gctcgtagac ctcggccgcc agcacgccgc ccagcgagaa
    20521 gccggagatg aggaatccgg aggcgcggtt gcgcagccgg gcgggccagc tctccagtac
    20581 gtaggtggcg ctggcgctgt actcgccggc catgcccatg ccgatcagca ggcgcgcggt
    20641 gaacaggctg gtgtagtccc aggcgaagcc gcaggcgaag gtgccgaccg agtacagcag
    20701 gatgctggcc accatggcgc tcctgcggcc gaagcggtcg ccgagcgcac cgagcacggc
    20761 gccgccgagc cagcgggtga tgaacgcacc ggacaccagg ctcgcggact cgacggtcga
    20821 cagtccgaag tcgtcggcga tctcggtcag tacgagggtg atgaggacga agtcgaagcc
    20881 gtcgaggaga tagccgatcc aggcggcgaa gaaggacttc cacttctgcc gggtgatctc
    20941 tctgtaccag gggcggggct tcgcggtggt gcgcgcagat gacatgacgg gtccaatgcg
    21001 gggtgcggat tcgcgcgtcg gggacgggga gcgggcagga ccggggccgg gcctgcggcc
    21061 ccggtccgcg ggtcacagga gaccggcctc ggtgagccgg tcgcggaccc gggccacggc
    21121 gcgttcgtcg aggggca
//
