LOCUS       NZ_CP094676            10216 bp    DNA     linear   CON 30-MAY-2024
DEFINITION  Streptomyces sp. CB09030 chromosome, complete genome.
ACCESSION   NZ_CP094676
VERSION     NZ_CP094676.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB09030
  ORGANISM  Streptomyces sp. CB09030
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Genomic of Streptomyces sp. CB09030
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2022) Xiangya International Academy of
            Translational Medicine, Central South University, Changsha, Hunan
            410013, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: Canu v. v1.5; Racon v. v3.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1510.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022827705.1-RS_2024_05_30
            Annotation Date                   :: 05/30/2024 05:11:20
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,205
            CDSs (total)                      :: 7,118
            Genes (coding)                    :: 7,015
            CDSs (with protein)               :: 7,015
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 40 of 103
            Pseudo Genes (incomplete)         :: 75 of 103
            Pseudo Genes (internal stop)      :: 10 of 103
            Pseudo Genes (multiple problems)  :: 21 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:41:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3815010
            Orig. end                         :: 3825226
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094676.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="22"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5216)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(1796..4018)
                     /locus_tag="L6J92_RS16370"
                     /old_locus_tag="L6J92_16370"
     CDS             complement(1796..4018)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978106.1"
                     /locus_tag="L6J92_RS16370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_16370"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_194274480.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2e-39, bitscore:
                     133.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAQETRGRRRAAPPRRSVPKSGAKTVRTPTVLQMEAVECGAAS
                     LAMVLGHYGRHVPLEELRIACGVSRDGSRASNLLKAARSYGFTAKGMQMDLAALAEVAT
                     PAILFWEFNHYVVYDGMGRRFGRRGVFINDPGKGRRFVSLEDFDGSFTGVVLTMEPGAD
                     FTRGGRRPGVLGAMPARLRGTAGTLPAAVLASLLLVAVGAAVPALSRTYIDMFLIGGQT
                     SLLGVLFASMAACVLLTVLLTWLQQANLLHGRIISSTLSSARFLRHLLRLPVTFFSQRS
                     PADLVQRLQSNDAVAETLARDLAAAGVDAIVVVLYAVLLYTYDPQLTFVGIGVALLNIL
                     AMRVVVRLRATRTAKLRADTARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHATTLE
                     EQQRLGVPSAWLGVVAPTLATLNSGLILWIGGMRAVEGHISVGLLVAFQSLVVRFTAPL
                     TRLNGVAGRIQDFAADVARLKDVENFRTDPLYDRPGGPDSTRRLQGHVELQNVSFGYNP
                     LDTPLLTGFDLTVGPGQQVALVGGSGSGKSTVSRLISGLYAPWDGVIRIDGQRLEDVPR
                     GALAASVSFVDQDVFLFEGSVRDNVALWDPSIPDTAVVDALKDAALYDVVMRRPGGIGS
                     PVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETELVVMDNLRRRGCACV
                     VIAHRLSTVRDSDEIVVLEHGSVVERGRHEQLVAHGGAYAALVRER"
     gene            complement(4015..4821)
                     /locus_tag="L6J92_RS16375"
                     /old_locus_tag="L6J92_16375"
     CDS             complement(4015..4821)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="L6J92_RS16375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_16375"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_031031872.1"
                     /transl_table=11
                     /translation="MQFRQQALSKLQSPDELDLPVRLARPQGWLVLSVTVVAMAAASVW
                     AVGGSVTSTVSAPAILTHGQGSYLLQSPVSGQVTAVLARPGQRLGADAPVLKVRTADGE
                     SVVRTVDAGRVSALAATVGQIIQTGANVASVEKVAHTGDPLYATVYVPADNAAAVPANA
                     SVDLTVQSVPTQQYGVLHGKVKSVDRSAQSAQTIGAFLGDSQLGEQFTKDGRPVAVTVR
                     LTASESTKSGYAWSSADGPPFELTSMTLASGSIRLADQRPVDWLLP"
     gene            complement(5001..5216)
                     /locus_tag="L6J92_RS16380"
                     /old_locus_tag="L6J92_16380"
     CDS             complement(5001..5216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="L6J92_RS16380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_16380"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_194274478.1"
                     /sec_met_domain="strepbact (E-value: 1.3e-36, bitscore:
                     123.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSIPQVETAEISDADLDNVSGGLNVNAVGTVTGLVDGVAPVSGL
                     VNTAVGTVEGVTGLNTAPVTGLVAGL"
     gene            5823..7193
                     /locus_tag="L6J92_RS16385"
                     /old_locus_tag="L6J92_16385"
     CDS             5823..7193
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007500817.1"
                     /locus_tag="L6J92_RS16385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_16385"
                     /product="S1 family peptidase"
                     /protein_id="WP_243781471.1"
                     /transl_table=11
                     /translation="MSHKRIPKRKAAMAAGGVVALGAAAILLPNANASQDGGGSHDAAA
                     APRTLKAADASDLASQLAGQLGDAFAGSYYDAGAQRLVVNVVPGDDDQVAVRAQRAGAE
                     IREVDNSMTELHGGAQTLKSEATIPGTSWAIDPRTNKILVTADSTVTGEKWDRLESTVG
                     RLGSGMATLEKSAGTFKTFVSGGDAIFGGGARCSLGFNVTAGDDSPAFLTAGHCGVAAD
                     AWSDAQDGQPIGTVDQAVFPGEGDFALVTYDDPATEAPSEVNLGDQTLQISGAAEATVG
                     EQVFRMGSTTGLADGQVLGLDATVNYPEGTVSGLIQTDVCAEPGDSGGSLFTQDGLAIG
                     LTSGGSGDCTAGGETFFQPVTTALEAVGATLGDDAGDGAGEQPGGEEAGGAGAGGDEAG
                     GDGAGGGDAVGGGDEAGGEQPGGDDAGDSTGAGGSVSGSGSDDGTGTGAGDGSGPLG"
     misc_feature    7429..7443
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.6"
                     /tool="antismash"
     gene            7523..9970
                     /locus_tag="L6J92_RS16390"
                     /old_locus_tag="L6J92_16390"
     CDS             7523..9970
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068579.1"
                     /locus_tag="L6J92_RS16390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_16390"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_195887370.1"
                     /transl_table=11
                     /translation="MGGEGAAERGSRTLRAEGALKAIAAGPDRQERTRRVLEQALVFAG
                     ASCAALYTPGDHRDLLCLVESAGVPRTLYGVRDSYPASGGSPVADAHRGGAAVWVGPEE
                     FAGSAESRRVPSSGLSLAALPVRGDGGGCLLALTGHPDGFGAEDRACLELIAEALTCPV
                     PTEAAEGGELRPTAFTLAMDSGRVEVGDGVLRLFGLAPGEFDGRVETLLGLTVPEDLPS
                     LMSVTEADHMTIGDRELEFRVLQPTGPPKWLRLSGRLLPGGEGRPTRLLGTVADASTLR
                     PDVTDVARVQRLAAALATAGTVRDVSQAVVAALRRPLRADRIALAELENERLVVTVLDP
                     PDPESWPELWRLEWRTEWPDAPVRAMPTLAAALREGRARIWPAGTGDLEPALADVGPGG
                     LAVLPLPAGGRMAGACLIGWDAPHDFGPDERALLTASAGLAGQALMRAHAFDAEHELVG
                     MLQRQLLPRRLPELPGAVAVARYLPSTAGLELGGDWYDVIPLPDHHVALVIGDVQGHSA
                     GAATLMGQMRTALRAYAAEGHPPDVVVSHANRLLVDMETDLFATCVYVDLDMEAGAAWC
                     VRAGHLPPVLRHPDGSTEIAEAEGGPPLGVVPQADFPMSPLRLRPGTLIALTTDGLVET
                     PESDIDAGLDRFAHALAGSDPAHLGLLADALLGEARRSDDVALLLVRYDGMDLRPLRES
                     WSVWRLPEAVRHARRFARRTLRSWDVPDDTTDGVLLIVSELVTNALVHTDGQVRLDLAL
                     IGGRLRVAVADASPRTPAKPTSIGWEATGGRGILLVEAMSAAWGTLPVGGGKQVWSEIA
                     LEE"
     misc_feature    10082..10097
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.08"
                     /tool="antismash"
     misc_feature    complement(10085..10100)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.64"
                     /tool="antismash"
ORIGIN
        1 gaaccgttcc gcccacgccg cgtaggcgta gttctccgcc gccgccaccc gcagcttcgg
       61 gaggccgcgc agtgtctgga acgcctggtt gttcagcttg ttggtgagct tgaccagccg
      121 ccgctgccag cgcacctgcc acagcccgag gcccaggaag accccggcca cgaccaccag
      181 catgccgatc gccgccagcg ccatcggcac gctgaaccag agcagtagcc ccaggttcat
      241 cgccccgacg gtcaccgact gggccaccgt cgggccgacg cccgccagca gccggcggat
      301 cgcgctgatg cccatcgccg cgctcgccag ctcgccggtc gagcgctcgg tgaagaactt
      361 cgtcggcagc ctcagcagcc ggtcccacac ggccggttgc agcgtcgcct cgacccggcc
      421 ttccagccgc aggatggtga ggttctgcaa cagcatgaag gccgccgcga cgacaccgct
      481 cagcatcacc gcgagacaca cctgcacgat cagcccggtc tgcgccgtcg gcacgaactc
      541 gccgagcacc cggcccgtcg cgatcggcac cagcgcgccg agccccaccg tcaccaggcc
      601 gctcagcagc agcccggtca gatcccggcg ggtgcccgcc aggcagaacc gcagcagccc
      661 gagcggaccg agccggccct ccggcagcgg ccggtagaac atcaccgcgc tcggctcgaa
      721 ctcctcggcg ttgtcccgct ccaccggagt ctcccggccg gtcgccggat gcacggccgc
      781 atagccgccg cgccgccaca gcagcgccac cggcgccccc gacagactcc ggtgcccgac
      841 cagcggcccc acgtcgtccc gccaccagcc gtcctccagc cgcaccgtgc gggtccgcag
      901 ccgcgaggcg agggcgaccc gctcgaccgg atcgagccgc tcgctctccg tgccgccccg
      961 cgcgggctcg gcgagcggga tcccggcggc gcgggcgacc agccggcacg ccgcgtacga
     1021 ggcgtcggcg tcggcggccg tggcgcgccc cgccgaccgc ttcccgatgg aggccagcag
     1081 ggtccggtcg gcctgcgcgc gcacggcctc acccgccttg attccggccg ccgtccgcgt
     1141 ctcgtgggtg cgctccaact gctcgatcca gcggtccagc gtcgtcagca gccggtactg
     1201 ctggtcgacc aggctctgcc acagcgccgg gtccatcagc aggtcggcgg cggcctcctc
     1261 gccgtacacc gccccgtact gcacgctgcc cggcggcacc tgcatccaga acacgtcgtc
     1321 gtcggtgggc gcggcggccc gttccgcggc catcggcgcc tggaacagga ccgtcaggcc
     1381 gcggcccacg ccgagcgcca gggcgtactc cagcgggctc gtcgtcggcg gcacgtactg
     1441 cgggttgccg tactcgtcgt acgaccacgt ctgcgtgggc gccggctggt acagctcgcg
     1501 cagcccgatg cggtgcacca cgcagtcccg cagcggacgc gcgaccaggg tgtgctgcgg
     1561 gcccgccacc ggaccgagca gcgccgagcc cgcctccagc cgccccaggt ggtgccagtg
     1621 gccctgctcc ccggcgtcga ccgcgaacag gtcgaccgcg ccggacgcca ccagccacag
     1681 cacctgtggc ccctccaggt cgaggcggtt gagcccggcg cagtccaccc gcgtgcccag
     1741 cgcgccgagc gccccgagga cgaggtcgcc ctgtccgtcg tgcacggccg tcatctcacc
     1801 gctccctgac cagcgccgcg tacgcaccgc cgtgcgccac cagctgctcg tgccgtccgc
     1861 gctccacgac gctgccgtgc tccaggacga cgatctcgtc gctgtcccgc acggtgctca
     1921 gccggtgcgc gatcaccacg caggcgcagc cgcgccggcg caggttgtcc atgaccacca
     1981 gctccgtctc cgcgtccagc gcgctggtca cctcgtccag gaccaggatg ctgggacggc
     2041 gcaccagggc ccgcgcgatc tccaggcgct ggcgctgccc gccggagaag ttgcggccgt
     2101 cctgctcgac cgggctgccg atgccgccgg gacgccgcat cacgacgtcg tacagtgccg
     2161 cgtccttgag cgcgtccacc accgcggtgt ccgggatcga cgggtcccac agcgccacgt
     2221 tgtcgcgcac cgagccctcg aacaggaaca cgtcctggtc gacgaaggag accgaggcgg
     2281 ccagcgcccc gcgcggcacg tcctccagcc gctgcccgtc gatgcggatg accccgtccc
     2341 acggggcgta caggcccgag atcagccggg acaccgtgga cttgccgctg cccgagccgc
     2401 ccaccagcgc cacctgctgc ccggggccca cggtcaggtc gaagccggtc agcagcggtg
     2461 tgtcgagcgg gttgtagccg aaggagacgt tctgcagctc gacgtgcccc tgcagccggc
     2521 gggtggagtc cgggccgccg gggcggtcgt agagcgggtc cgtgcggaag ttctccacgt
     2581 ccttcagccg cgccacgtcc gccgcgaagt cctggatgcg gcccgccacg ccgttcaggc
     2641 gggtcagcgg ggccgtgaaa cggaccacca gcgactggaa ggcgaccagc agcccgaccg
     2701 agatgtgccc ctcgaccgcg cgcatgccgc cgatccacag gatcagcccg ctgttcagcg
     2761 tcgccagggt cggcgcgacc accccgagcc aggcactcgg cacccccagc cgctgctgct
     2821 cctccagcgt ggtggcgtgc tgccccgccc acttgcggaa gtagccgtcc tcgccgcccg
     2881 tcgccttcat cgtctcgatc agctgcaggc cggtgtacgc ggtgttcgtc agccgcgccg
     2941 tgtcggcccg cagcttcgcc gtacgggttg cccgcagccg cacgacgacc cgcatcgcga
     3001 ggatgttgag cagcgccacg ccgatcccga cgaaggtcag ctgcgggtcg tacgtgtaca
     3061 gcagcaccgc gtacaggacg accacgatcg cgtccacgcc cgccgccgcg aggtcgcggg
     3121 ccagcgtctc ggcgacggcg tcgttggact gcaggcgctg caccaggtcg gccgggctgc
     3181 gctgcgagaa gaacgtcacc ggcagccgca gcagatgacg caggaagcgg gcgctggaga
     3241 gggtggagga gatgatgcgg ccgtgcagca ggttggcctg ctggagccag gtgagcagga
     3301 ccgtgagcag cacgcaggcc gccatcgagg cgaacagcac accgagcagc gaggtctgcc
     3361 cgccgatcag gaacatgtcg atgtaggtgc ggctgagcgc gggcaccgcc gcgccgaccg
     3421 ccaccaggag caggctggcc agcacggcgg ctggcagcgt cccggcggtg ccccgcagcc
     3481 gggccggcat cgcgccgagc acgccgggcc tgcggccgcc ccgggtgaag tccgcgcccg
     3541 gctccatggt caggacgacg ccggtgaagc tgccgtcgaa gtcctccagg gacacgaaac
     3601 gccggccttt gcccgggtcg ttgatgaata cccctcgccg cccgaaccgg cggcccatgc
     3661 cgtcgtagac gacgtagtgg ttgaactccc agaacaggat ggccggcgtc gccacctcgg
     3721 cgagcgcggc caggtccatc tgcatgccct tggcggtgaa cccgtaactg cgggcggcct
     3781 tcaggaggtt gctcgcccgg gagccgtcgc gggagacgcc gcaggcgatc cgcagctcct
     3841 ccagcggaac gtgccggccg tagtggccga gcaccatcgc gagggaggcg gcgccgcact
     3901 cgacggcttc catctggagc acggtggggg tgcggacggt cttcgcgccg ctcttcggca
     3961 cgctgcgccg gggcggggcg gcgcggcgtc tgccgcgggt ctcctgggcg gtactcacgg
     4021 cagcagccaa tcgacgggac gctggtcggc caggcggatc gagcccgagg ccagggtcat
     4081 ggaggtcagt tcgaacggcg gcccgtccgc cgacgaccac gcgtagccgc tcttcgtcga
     4141 ctccgaggcc gtcagccgca ccgtcacggc caccggcctg ccgtccttgg tgaactgctc
     4201 gccgagctgg ctgtccccga ggaacgcgcc gatcgtctgc gccgactgcg ccgagcggtc
     4261 caccgacttc accttcccgt gcaggacccc gtactgctgg gtcggcaccg actgcacggt
     4321 caggtcgacg gaggcgttcg cgggtacggc ggcggcgttg tccgccggca cgtagacggt
     4381 ggcgtacagc gggtcgccgg tgtgggcgac cttctcgacc gaggcgacgt tcgcgccggt
     4441 ctggatgatc tggccgacgg tggcggcgag cgcgctgacc cggccggcgt cgaccgtgcg
     4501 gaccacgctc tcgccgtcgg cggtgcggac cttcagtacg ggggcgtcgg cgcccagccg
     4561 ctgacccggc ctggcgagga ccgcggtgac ctgcccggag acggggctct gcaggaggta
     4621 actgccctgg ccgtgcgtga gaatggcggg cgcggagacg gtggaggtca ccgagccgcc
     4681 caccgcccac acggacgcgg cggccatcgc gaccacggtc acggacagca ccagccagcc
     4741 ctgcggacgg gcgagacgca ccggaagatc gagctcatcc ggcgactgga gcttggagag
     4801 ggcctgttgg cggaactgca cggcggacgt accccagtga ttcccgtgat tccccgtgat
     4861 tcgccgtgct cccgaagagc ctcgtgagca cgagaggacc gggtgggacg agtgggttgg
     4921 cggaaggaag gcgtcgggtg gaacggccga agagccccgg agcctgggcg gctccgggac
     4981 tcagcggcac aagggcgcga tcagagaccg gcgaccaggc ccgtgaccgg ggcggtgttc
     5041 agaccggtga caccctcgac ggtgccgacg gcggtgttga ccaggccgga gaccggggcg
     5101 acgccgtcca ccaggccggt gacggtgccg acggcgttca cgttcaggcc gccggagacg
     5161 ttgtcgaggt cggcgtcgga gatctcggcg gtctcaacct gggggatgga gttcatgtgg
     5221 gaacttccct tcgtatagcc atttcacaag gggggagcgg ccccctctgg ggacagatga
     5281 cggccgcgac cgcggacacc gggcgcccgt ttccggagcg tccccggcct ccgcggtgcg
     5341 atggatcaaa gcacgcgtgc cgtccgggct tccaatcaac caccccctcc caccagggga
     5401 cttgcaacgc cgacgcgccc aacggtgcag ggccgggcac gccttcgggg cgacttcttc
     5461 acaccgtgcg cgacatcggc ccggacgccc cccttgccgg gccccggccg attggggcac
     5521 tcccgcccca aagacgtacc gcccggcggc gggttgtgca gatccgccaa cgaggatgac
     5581 cgggttgggc attcgatgtg cagattcacg gaagcgccga ttccgcccca ggatcggcac
     5641 gccgggtcgc cggccggcca cggggagtgg cgggtggtgg gggtgtgcgg gtgcggcccc
     5701 gggtgcgggg gagggccggt ctgaacgcac cgcgcggtcc gtgcgtacca acagccgtca
     5761 aggcgccccc aacagcagcc gggccggtgg cacggtccac cggccccagg aggtcgagta
     5821 ggttgagtca caagcgaatt ccgaagcgca aggccgcgat ggccgcgggc ggtgtggtgg
     5881 cgctcggcgc ggccgccatc ctcctgccga acgccaacgc ctcgcaggac ggcggcggtt
     5941 cacacgacgc cgcggcggcc ccgcggaccc tcaaggcggc ggacgcctcg gacctcgcct
     6001 cgcagctcgc cggccagctc ggcgacgcct tcgccggctc gtactacgac gccggtgcgc
     6061 agcggctcgt cgtgaacgtc gtccccggtg acgacgacca ggtcgcggtg cgggcccagc
     6121 gggcgggcgc ggagatccgc gaggtcgaca acagcatgac cgagctgcac ggcggcgcgc
     6181 agacactgaa gtccgaggcg accatccccg gcacctcgtg ggcgatcgac ccgcgcacca
     6241 acaagatcct ggtgaccgcc gacagcaccg tcaccggcga gaagtgggac cggctggagt
     6301 ccacggtcgg gcgcctcggc tccggcatgg cgacgctgga gaagtccgcc ggcaccttca
     6361 agaccttcgt gtcgggcggc gacgccatct tcggcggcgg cgcgcgctgc tcgctcggct
     6421 tcaacgtcac cgcgggggac gattccccgg ccttcctgac ggccgggcac tgcggcgtcg
     6481 cggccgacgc gtggtccgac gcccaggacg ggcagccgat cggcaccgtc gaccaggcgg
     6541 tcttccccgg cgagggcgac ttcgcgctcg tcacgtacga cgacccggcg accgaggccc
     6601 ccagcgaggt caacctcggc gaccagaccc tgcagatctc cggggccgcg gaggcgaccg
     6661 tcggcgagca ggtcttccgc atgggcagta cgaccgggtt ggccgacggc caggtcctcg
     6721 gcctggacgc caccgtcaac tacccggagg gcacggtcag cggcctcata cagaccgacg
     6781 tctgcgccga gcccggcgac agcggcggct ccctgttcac gcaggacggg ctcgcgatcg
     6841 ggctgacgtc cggtggcagc ggcgactgca cagccggcgg cgagacgttc ttccagccgg
     6901 tcaccaccgc cctggaggca gtcggcgcca ccctcggcga cgacgcgggc gacggcgccg
     6961 gggagcagcc cggcggcgag gaggccggag gggccggcgc cggcggtgac gaggccggcg
     7021 gcgacggagc cgggggcggt gacgccgtcg gcggtggcga cgaggccggc ggcgagcagc
     7081 ccggcggcga cgacgcgggc gacagcaccg gcgcgggcgg ctccgtctcc ggttccggct
     7141 ccgacgacgg aacgggtacc ggcgccgggg acggctccgg cccgctcggc tgaccggggc
     7201 gccaacggga tcgaccggca cttcgacggc ggtccggtcc tccggcggga ggaccggacc
     7261 gccgcggtgt ccgtcgggag tactgggccg ccgcggtgca cgtccccgtc cctccccacg
     7321 cgcaccgccg gcctcgtgcg gaggtgatcg cacccggggc cgcccagcgc gggggcctcc
     7381 cacgcatcct ccgggtccgg cccgctcggg tgccgtcccg gccgggcgcg ggcgcgctcc
     7441 cacgcacgta cacacgcccc gcaccaccgg taacagctcc gcaggggctg cgcgggcgtc
     7501 gctttggcgc tgtaatggcg aagtgggcgg agagggtgct gcggaacgag ggtcgaggac
     7561 cctgcgggcc gagggcgccc tgaaggcgat cgccgccgga ccggaccgcc aggagcgcac
     7621 gcgccgggtc ctggagcagg cactggtctt cgcgggtgcc tcctgcgccg ccctctacac
     7681 gcccggcgac caccgcgacc tgctctgcct ggtcgagtcg gccggtgtgc cgcgcaccct
     7741 gtacggcgtg cgtgacagct atccggcatc cggcggctcc ccggtcgccg acgcccaccg
     7801 gggcggcgcc gcggtgtggg tcggtccgga ggaattcgcc ggttcggcgg agtcgcggcg
     7861 cgtgccgtcc agcggcctct cgctcgccgc gctgccggta cgcggggacg gcggcggctg
     7921 cctgctcgcc ctgaccgggc atccggacgg cttcggcgcc gaggaccgcg cctgcctgga
     7981 actgatcgcc gaggccctga cctgccccgt ccccaccgag gccgccgaag gcggggaact
     8041 gcggcccact gccttcaccc tcgcgatgga cagcggccgg gtcgaggtcg gcgacggcgt
     8101 cctgcggctg ttcggcctcg cccccggtga gttcgacggc cgggtcgaga cgctgctcgg
     8161 cctcaccgtg ccggaggacc tgccctcact gatgtcggtg accgaggccg accacatgac
     8221 catcggcgac cgcgaactgg agttccgcgt actgcagccc accgggccgc cgaagtggct
     8281 ccggctcagc gggcgcctgc tgcccggcgg cgagggtcgg ccgacccgcc tgctcggaac
     8341 cgtcgccgac gcctccacgc tgcgcccgga cgtcaccgac gtcgcccgcg tccagcggct
     8401 cgccgccgcc ctcgcgaccg ccgggaccgt ccgcgacgtc agccaggccg tggtcgccgc
     8461 cctgcgcagg ccgctgcgcg ccgaccggat cgcgctggcc gagctggaga acgaacggct
     8521 cgtggtcacg gtcctcgacc cgcccgaccc cgagtcctgg cccgagctgt ggcggctgga
     8581 gtggcgcacc gagtggccgg acgcgccggt acgggccatg cccaccctcg ccgccgccct
     8641 gcgcgagggc cgcgcccgga tctggcccgc cggcaccggc gacctggagc ccgcgctcgc
     8701 cgacgtgggc cccggtgggc tcgccgtgct gccgctgccc gccggcgggc gtatggccgg
     8761 cgcctgcctg atcggctggg acgccccgca cgacttcggc cccgacgaac gcgccctgct
     8821 caccgcctcc gccggcctcg ccggacaggc cctgatgcgg gcccacgcct tcgacgccga
     8881 acacgaactg gtcggcatgc tccagcgcca gctgctgccg cgccgcctgc cggagctgcc
     8941 cggcgcggtc gccgtcgccc gctacctgcc cagcacggcc ggactcgaac tgggcggcga
     9001 ctggtacgac gtgatcccgc tgcccgacca ccacgtggcc ctcgtcatcg gcgacgtcca
     9061 gggccacagc gccggcgccg ccacgctgat gggccagatg cgcaccgccc tgcgcgccta
     9121 cgcggccgag gggcacccgc cggacgtggt ggtctcgcac gccaaccggc tgctggtcga
     9181 catggagacc gacctcttcg ccacctgcgt ctacgtcgac ctcgacatgg aggcgggggc
     9241 cgcctggtgc gtgcgggccg ggcacctgcc gccggtgctg cgccatcccg acggcagcac
     9301 ggagatcgcc gaggccgagg gcggcccgcc gctcggcgtg gtgccgcagg ccgacttccc
     9361 gatgagtccg ctgcggctgc ggcccggcac cctgatcgcc ctcaccacgg acggcctggt
     9421 ggagacgccg gagagcgaca tcgacgcggg cctcgaccgg ttcgcccacg cgctggccgg
     9481 ctccgacccc gcccacctgg ggctcctcgc cgacgccctg ctcggcgagg cccgccgcag
     9541 cgacgacgtc gccctgctcc tggtgcgcta cgacggcatg gacctgcgcc cgctgcggga
     9601 gagctggtcg gtgtggcggc tgccggaggc cgtgcggcac gcccgccgct tcgcccggcg
     9661 caccctgcgc tcctgggacg tcccggacga caccaccgac ggcgtcctcc tgatcgtctc
     9721 cgaactcgtc accaacgccc tcgtgcacac cgacggccag gtccgcctcg acctcgccct
     9781 gatcggcggc cggctgcgcg tggcggtcgc cgacgcctcg ccccgtacac cggccaaacc
     9841 gaccagcatc ggctgggagg ccaccggcgg gcgcggcatc ctcctcgtcg aggcgatgtc
     9901 ggcggcgtgg gggacgctgc cggtcggcgg gggcaagcag gtctggagcg agatcgcgct
     9961 ggaggagtga acggcgtccc ggtccggccc gtgggccgcc gtgcccggtg tttcacggag
    10021 cccggtccgg ggacccgccc gggcgagtgc accggacgcg gaagcgacgc gccagaagca
    10081 gaaggaagat gatgctcgtg accacggaca ccagcggcaa agccgctgtc cgtcgggtgg
    10141 agaccggatg gtcgaaggcc cgccggctgc gggggagtgg cctgatgcgc acctgcgtac
    10201 ccgccgtcga ggacgg
//
