LOCUS       NZ_CP094676            25558 bp    DNA     linear   CON 30-MAY-2024
DEFINITION  Streptomyces sp. CB09030 chromosome, complete genome.
ACCESSION   NZ_CP094676
VERSION     NZ_CP094676.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB09030
  ORGANISM  Streptomyces sp. CB09030
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Genomic of Streptomyces sp. CB09030
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8368456)
  AUTHORS   Shi,J. and Huang,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2022) Xiangya International Academy of
            Translational Medicine, Central South University, Changsha, Hunan
            410013, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2021
            Assembly Method                   :: Canu v. v1.5; Racon v. v3.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1510.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022827705.1-RS_2024_05_30
            Annotation Date                   :: 05/30/2024 05:11:20
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,205
            CDSs (total)                      :: 7,118
            Genes (coding)                    :: 7,015
            CDSs (with protein)               :: 7,015
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 103
            CDSs (without protein)            :: 103
            Pseudo Genes (ambiguous residues) :: 0 of 103
            Pseudo Genes (frameshifted)       :: 40 of 103
            Pseudo Genes (incomplete)         :: 75 of 103
            Pseudo Genes (internal stop)      :: 10 of 103
            Pseudo Genes (multiple problems)  :: 21 of 103
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:41:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1406081
            Orig. end                         :: 1431639
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP094676.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25558
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="4"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25558
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25558
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15558](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15558)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     misc_feature    212..225
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.43"
                     /tool="antismash"
     misc_feature    complement(280..295)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 24.73"
                     /tool="antismash"
     gene            complement(618..1160)
                     /locus_tag="L6J92_RS06375"
                     /old_locus_tag="L6J92_06375"
     CDS             complement(618..1160)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437887.1"
                     /locus_tag="L6J92_RS06375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06375"
                     /product="PPA1309 family protein"
                     /protein_id="WP_195889897.1"
                     /transl_table=11
                     /translation="MSNTPMAASPLTRAVLEIDEYVSGLGWDQPARLFALVDTARLRAD
                     QPSLADRLGLQDEPESSGLTPIEQDEIPTAQPLDEFLGTIAWPDAVVGCALAVERLMLP
                     PSAEAQVPEGLDETKLARWVAEHPERQEVRMTVAVLRDGARDSALRLREKDSATEVLTG
                     SDLVPGLAQALTATFAE"
     gene            1326..4262
                     /locus_tag="L6J92_RS06380"
                     /old_locus_tag="L6J92_06380"
     CDS             1326..4262
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009190532.1"
                     /locus_tag="L6J92_RS06380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06380"
                     /product="UPF0182 family protein"
                     /protein_id="WP_243783012.1"
                     /transl_table=11
                     /translation="MPDRGGGPPTGPRIRVGRPSRRVRTLLLTLGVLAVLAMAFTMFAG
                     FWTDWLWYRSVHYSSVFTTTLWTKIGLFFVFGLLMALAVGFNIWLAHRLRPPLSAMSME
                     QQNLDRYRMGIAPYKKWLLLGITALVGLIAGASASGQWRTWLMWVNGVPFGQKDPQFKL
                     DVSFYAFDLPWYRFLLGFGFAAVIISVIAAALTHYLYGGLRVTSPGARATAAATGHLSV
                     LIGVFVALKAVAYWLDRYGLAVKSSDFKATDNWTGLRYVDANAYLPAKTILFCIAVICA
                     LLFFATLWRRTWQLPVIGFGLMVLSAILIGGLYPALVQKFQVQPNEQAKEAPYVEKNLA
                     ATRDAYGIEGTQVTEYAGKSETKDKTKLRGDVDAAASIRIMDPNVVSPTFQQLQQMRNY
                     YAFPTNLDVDRYSKDGKDQDTVIGLRELNLAGIPKKNWINNHFRYTHGYGVVAAKGTAV
                     DSEGRPVFTESDLPSKGDLGEYEQRVYYGEKTTTYSIVGGPQKEIDYSDDTGEKTFSYK
                     GDSGVDLSNAVNRAAYAAAFGEPQILYSGAIGDGSRILYNRTPKERVEAVAPWLTIDGD
                     AYPAVVDGRIQWIVDAYTTTNGYPYASRTTLGDTTADSLTANNNSRAVVAQENQVNYIR
                     NSVKATVDAYSGDVKLYQWDTKDPVLKTWMKAFPDTVQDKGEISKELMAHLRYPQDLFK
                     VQRELLTRYHVKDANTFLSGSEVWQVPDDPTNKSSDSVPPYYLSMKMPDQKQQAFSLTT
                     TFTPNGRDNLSAFMAVDAEAGTSDYGKIRILKLPTSTTVNGPKQVQSQLNSEQDIAETI
                     RLLRGGDSEVEYGNLLTVPVDGGLLYVEPVYVRGGDLKYPLLRKVLVSYGGNTAFENTL
                     DEALSKVFGAQAAENEQPPDEGDDTTEPPPTSTNPTVKEALGDAQKAFDAGQKALEQKD
                     LGAYAEAQKDLEEALQRAEDAQAKADQGTGKNGDENGGGDTGGGSDTG"
     tRNA            4341..4414
                     /anticodon=(pos:1410456..1410458,aa:Met,seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="L6J92_RS06385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="L6J92_06385"
                     /product="tRNA-Met"
     gene            4341..4414
                     /locus_tag="L6J92_RS06385"
                     /old_locus_tag="L6J92_06385"
     misc_feature    complement(4486..4499)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.13"
                     /tool="antismash"
     gene            4652..6541
                     /locus_tag="L6J92_RS06390"
                     /old_locus_tag="L6J92_06390"
     CDS             4652..6541
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1295: Sel1 domain
                     protein repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030113.1"
                     /locus_tag="L6J92_RS06390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06390"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_243780656.1"
                     /transl_table=11
                     /translation="MGDMANLFGTGRFAQPSGQEEATDEAQEAADEAAEEVRLLLAVDG
                     GDAEAMSVLGAMLLRRGDFEGAESHLRAATAAGDRAAANNLGVLLHQRGYADEAAGWWR
                     IAAVAGSVPAAHALGRHFRERGDEPAAEYWLCQSAEQGHVLGAYALADLLEHRGDDTGA
                     ERWMRAAAERGHREAAYRLARTLDRRAGEAGCAGQSGRRAGQGRDGGRDGGRAGASGGD
                     LGADSGTGEVEQWYRQAAARGHRRAALQLGAILEKRGELKEAGRWYLTSAKDGEARAAC
                     ALGFLLRDAGDTESAAVWWLRAAQDGDGNAANALGALHAERGETQTAERWYRAAMDAGD
                     DNGAYNLGLLCAEQGRTAPAEQWYRRAAYAGHREASNALAVLLLRAGDRTGAEPWFSKA
                     AEAGSVDAAFNLGILHAGRGEEKVALRWYERAAAAGHTEAALQVGIARLRAGDERDAER
                     FLRCAAGGGSAEAAYRLATLLDARRPPAPAHELGEPEQGKSECEEWYERAASQGHRRAQ
                     VRVGMLAAARGDVVEAARWYREAAEAGSRNGAFNLGLLLAREGSEPEAVVWWRRAADAG
                     HGRAALRLALVFARRGELAEGQRWADLAVSLGPVEVGKRAARLRDALRQELSA"
     misc_feature    complement(4656..4666)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     tRNA            complement(6782..6855)
                     /anticodon=(pos:complement(1412900..1412902),aa:Met,
                     seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="L6J92_RS06395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="L6J92_06395"
                     /product="tRNA-Met"
     gene            complement(6782..6855)
                     /locus_tag="L6J92_RS06395"
                     /old_locus_tag="L6J92_06395"
     gene            complement(6907..7323)
                     /locus_tag="L6J92_RS06400"
                     /old_locus_tag="L6J92_06400"
     CDS             complement(6907..7323)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1266: hydrogen
                     peroxide sensitive repressor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005480466.1"
                     /locus_tag="L6J92_RS06400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06400"
                     /product="Fur family transcriptional regulator"
                     /protein_id="WP_031033214.1"
                     /transl_table=11
                     /translation="MSDLLERLRGRGWRMTAQRRVVAEVLDGEHVHMTADEVHSRAVDK
                     LPEISRATVYNTLGELVTLGEVLEVATDKRAKRYDPNAHQPHHHLVCARCGAIRDVHPT
                     GNPLADLPDSERFGFTVSDVEVTYRGTCPNCATA"
     misc_feature    complement(7390..7403)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.45"
                     /tool="antismash"
     gene            7470..8921
                     /locus_tag="L6J92_RS06405"
                     /old_locus_tag="L6J92_06405"
     CDS             7470..8921
                     /EC_number="1.11.1.6"
                     /GO_function="GO:0004096 - catalase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980376.1"
                     /locus_tag="L6J92_RS06405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06405"
                     /product="catalase"
                     /protein_id="WP_194276049.1"
                     /transl_table=11
                     /translation="MTQGPLTTEAGAPVADNQNSETAGVGGPVLVQDQLLLEKLAHFNR
                     ERIPERVVHARGAGAYGTFTVTADVTRYTRAAFLSEVGKETETFLRFSTVAGNLGAADA
                     VRDPRGFALKFYTEEGNYDLVGNNTPVFFIKDAIKFPDFIHTQKRDPYTGSTEMDNVWD
                     FWGLSPESTHQVTWLFGDRGIPASYRHMDGFGSHTYQWSNAAGEAFWVKYHFKTDQGIK
                     TLTQAEADKLAGADPDSHQRDLRQAIERGDFPSWTVGVQVMPVAEAAQYRFNPFDLTKV
                     WPHADYPIVWFGKLELNRNPENVFAEVEQSIFSPSHFVPGIGPSPDKMLQGRLFAYGDA
                     HRYRVGINADHLPVNRPHATEARTNSRDGHLYDGRHKGAKNYEPNSFGGPFQTDRALWQ
                     PVAVSGATGETEAPSHAEDNDFVQAGNLYRLMTDGEKERLIENLAGALSDVSRDEIVER
                     AVGNFRQADGDFGKRLEAAVQALRG"
     gene            complement(9006..10004)
                     /locus_tag="L6J92_RS06410"
                     /old_locus_tag="L6J92_06410"
     CDS             complement(9006..10004)
                     /EC_number="1.13.12.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016703 - oxidoreductase activity, acting
                     on single donors with incorporation of molecular oxygen,
                     incorporation of one atom of oxygen (internal
                     monooxygenases or internal mixed function oxidases)
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076851.1"
                     /locus_tag="L6J92_RS06410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06410"
                     /product="nitronate monooxygenase"
                     /protein_id="WP_194276048.1"
                     /transl_table=11
                     /translation="MTRIATPLTELLGIDLPVVQAGMSWASSSSALPLAVSRAGGLGVV
                     AAGPMRLPDLARTLDETAAGTDRPWAVNLPLYRAGADEVVELLLARRPPVLIASQGGPR
                     RYLDRFHDVGTVCLHVVAGVEHARKAADAGVDGLVVVGAEAGGHPPPAMVATQVLVRAV
                     VSAVPGVPVVASGGVADGAGLAAMLALGADGAQFGTRFLATEEATVHPGYKAAVVAAGV
                     DSTRTVGRGLGTIRALDNDFTRRMTRLEEDGTELDVRRGAFASASLKDAALDGLVDTGK
                     VEAGQSAGLVDAVLPAREVVDRIVAEYRRAVTRLPLPTEEPRPAPAGTAGA"
     gene            complement(10001..11629)
                     /locus_tag="L6J92_RS06415"
                     /old_locus_tag="L6J92_06415"
     CDS             complement(10001..11629)
                     /NRPS_PKS="Domain: AMP-binding (18-433). E-value: 4.9e-85.
                     Score: 277.5. Matches aSDomain:
                     nrpspksdomains_L6J92_RS06415_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076853.1"
                     /locus_tag="L6J92_RS06415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06415"
                     /product="AMP-binding protein"
                     /protein_id="WP_195889895.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-96, bitscore:
                     322.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLDLAAACPLTAHAALERAALLAPDVEAVVTAAERITYRDLAA
                     EVVRVRAALTAAGIGRGDRVGLCLGNGPRWVALFVALGSVGAVTVPVNTRYSADEVRHT
                     LAHARVGTLFVADRVLNVDFHAVLREIGIGADATPTCPALPALERVVVCGDAVPGWATP
                     WPEFLARGTGEVPATGTPDDVLLVQYTSGTTARPKGVLLTHRSMCADGFFSGARLGLRP
                     GDRFHSARPFFHVAGSTLSVLACLQHATTLVTMPRFEPAEALRLLEEERCTHFSGNDTI
                     ALLLLNHPDLAHRALRLRGAWVAASPTVIRRVIDELGAAECVAGYGLSEASPNVAQSCW
                     WEPDEVRASGAMLAEPGVEVRIRALDGSRDCGPGEPGSILVRGWNVMQGYLDDPAATAA
                     AVDPDGWLATGDVGVLDASGRLHFTGRTKDIIRVGGENVAPADVEDVLHRHPGVRQAVV
                     VGVPDERLMEVPFAFVVLTGPGPTEQELIDWARTRMAGFKVPRHLRIVDGFEGIGMTAS
                     SKVQKNRLAAHARTLLGHDGTGAAA"
     aSDomain        complement(10331..11575)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L6J92_RS06415_AMP-binding.1"
                     /evalue="4.90E-85"
                     /label="L6J92_RS06415_AMP-binding.1"
                     /locus_tag="L6J92_RS06415"
                     /protein_end="433"
                     /protein_start="18"
                     /score="277.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ERAALLAPDVEAVVTAAERITYRDLAAEVVRVRAALTAAGIGRGD
                     RVGLCLGNGPRWVALFVALGSVGAVTVPVNTRYSADEVRHTLAHARVGTLFVADRVLNV
                     DFHAVLREIGIGADATPTCPALPALERVVVCGDAVPGWATPWPEFLARGTGEVPATGTP
                     DDVLLVQYTSGTTARPKGVLLTHRSMCADGFFSGARLGLRPGDRFHSARPFFHVAGSTL
                     SVLACLQHATTLVTMPRFEPAEALRLLEEERCTHFSGNDTIALLLLNHPDLAHRALRLR
                     GAWVAASPTVIRRVIDELGAAECVAGYGLSEASPNVAQSCWWEPDEVRASGAMLAEPGV
                     EVRIRALDGSRDCGPGEPGSILVRGWNVMQGYLDDPAATAAAVDPDGWLATGDVGVLDA
                     SGRLHFTGRTKDIIRV"
     CDS_motif       complement(10430..10513)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_L6J92_RS06415_0002"
                     /evalue="3.50E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="L6J92_RS06415"
                     /protein_end="400"
                     /protein_start="372"
                     /score="22.6"
                     /tool="antismash"
                     /translation="PGEPGSILVRGWNVMQGYLDDPAATAAA"
     CDS_motif       complement(11018..11071)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_L6J92_RS06415_0001"
                     /evalue="3.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="L6J92_RS06415"
                     /protein_end="204"
                     /protein_start="186"
                     /score="22.8"
                     /tool="antismash"
                     /translation="VQYTSGTTARPKGVLLTH"
     gene            complement(11626..12576)
                     /locus_tag="L6J92_RS06420"
                     /old_locus_tag="L6J92_06420"
     CDS             complement(11626..12576)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (37-275). E-value: 5.9e-49. Score:
                     158.5. Matches aSDomain:
                     nrpspksdomains_L6J92_RS06420_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076854.1"
                     /locus_tag="L6J92_RS06420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06420"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_243780657.1"
                     /transl_table=11
                     /translation="MADAETPGADVPGAETPGADTPGAGTPDAETVRVRCDVADGVARV
                     RLARPRARNAVDLEMCLRLRAVFEDLDADDDVRVVLLSAEGPAFCAGADLKERAGRDAA
                     WVRRRRQASFAAYDAVERCRRPVVALVHGAVVGSGGEITLAADFAVAAEDTTFRFPEAH
                     WGTVGATQRLQRVIGRRRAKELLFTNRVMPAAEAADLGVVTRVVPGDRLARAGEEIAAS
                     IAGAPPLAMALTKRAVDLGGETDLDRGIRIEMAAIEQCLADGGWREGVDRFARRRDGGQ
                     GGTGGAGGPGGTDGAGSTDGHGSTDGHGSTEEEEK"
     aSDomain        complement(11752..12465)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L6J92_RS06420_ECH.1"
                     /evalue="5.90E-49"
                     /label="L6J92_RS06420_ECH.1"
                     /locus_tag="L6J92_RS06420"
                     /protein_end="275"
                     /protein_start="37"
                     /score="158.5"
                     /tool="antismash"
                     /translation="VADGVARVRLARPRARNAVDLEMCLRLRAVFEDLDADDDVRVVLL
                     SAEGPAFCAGADLKERAGRDAAWVRRRRQASFAAYDAVERCRRPVVALVHGAVVGSGGE
                     ITLAADFAVAAEDTTFRFPEAHWGTVGATQRLQRVIGRRRAKELLFTNRVMPAAEAADL
                     GVVTRVVPGDRLARAGEEIAASIAGAPPLAMALTKRAVDLGGETDLDRGIRIEMAAIEQ
                     CLADGGWREGVDRFAR"
     gene            complement(12563..13783)
                     /locus_tag="L6J92_RS06425"
                     /old_locus_tag="L6J92_06425"
     CDS             complement(12563..13783)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076855.1"
                     /locus_tag="L6J92_RS06425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06425"
                     /product="CaiB/BaiF CoA-transferase family protein"
                     /protein_id="WP_243780658.1"
                     /transl_table=11
                     /translation="MSAPTAPRPLEGVTVLDFSRVLAAPMATQILAELGATVVKVERPG
                     GGDETRGFEPRLPHGESAYFFAFNRGKRSVALDLKDPRGRDVARRLAARADVVVENFLP
                     GAMDRLGLGYDDLAAGNPGLVYVSATGFGQSGPDRTRKGYDTVFQALSGVMAMTGEPDG
                     PPSKTGIPVADMTSGLWVAIAVLTGLAGRGVSGRGRHFDVSMMDVQLSLHALNAARLFA
                     LDEDPARTGTQHPGRVPSAAFETADGGWLHISGSDQHWVPLCEVLGLDGLAADPELRHN
                     AGRIARREDVMTALRAAIARRERDPLLKELLAADVPAGAVRGVREALADPHARARGVVT
                     EFEHPTEGTFRALRTPLRETDGAPPVAGAPPLLGADTDAVLADLAGLGDEEIDELRAAG
                     VIQDGGR"
     gene            complement(13780..14550)
                     /locus_tag="L6J92_RS06430"
                     /old_locus_tag="L6J92_06430"
     CDS             complement(13780..14550)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (24-234). E-value: 4.4e-54. Score:
                     175.3. Matches aSDomain:
                     nrpspksdomains_L6J92_RS06430_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076856.1"
                     /locus_tag="L6J92_RS06430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06430"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_243780659.1"
                     /transl_table=11
                     /translation="MTVTTSGRPAAPSDPAADVLLVEDRGAVRVLTLHRPDKLNALNTA
                     LTRALSDALTAAEGDAGVRAVVLTGAGRAFCAGADLSEFSGLTPDQPDAVLERAALTAR
                     LQTQMQDMGTPVVSAVRGAAVGGGAGLAIGADMAVAGTDLKFGYPELRHSIVPALVMTG
                     LQRHLGRKLAFELVSTGRLLSAVEAAEHGLVNRVVEPDEVEGAALEIAERWAAVEPRAI
                     RAAKDLFYRVADLPTEAAMRAGQDVNALMRAFRR"
     aSDomain        complement(13849..14478)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L6J92_RS06430_ECH.1"
                     /evalue="4.40E-54"
                     /label="L6J92_RS06430_ECH.1"
                     /locus_tag="L6J92_RS06430"
                     /protein_end="234"
                     /protein_start="24"
                     /score="175.3"
                     /tool="antismash"
                     /translation="RGAVRVLTLHRPDKLNALNTALTRALSDALTAAEGDAGVRAVVLT
                     GAGRAFCAGADLSEFSGLTPDQPDAVLERAALTARLQTQMQDMGTPVVSAVRGAAVGGG
                     AGLAIGADMAVAGTDLKFGYPELRHSIVPALVMTGLQRHLGRKLAFELVSTGRLLSAVE
                     AAEHGLVNRVVEPDEVEGAALEIAERWAAVEPRAIRAAKDLFYRVAD"
     gene            complement(14611..15558)
                     /locus_tag="L6J92_RS06435"
                     /old_locus_tag="L6J92_06435"
     CDS             complement(14611..15558)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076858.1"
                     /locus_tag="L6J92_RS06435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06435"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_243780660.1"
                     /sec_met_domain="HMGL-like (E-value: 6.2e-41, bitscore:
                     139.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDAVTICECFARDGLQHEPGFVPTDTKISLLESFAAAGFRRVEA
                     TSYSHPRWVPAFADASEVLAGITHRPGVAFKATCPNPRAVRRALEDLGRGTGAEELSLL
                     VSASESHTQRNLRSTREEQWHRVAEMTELAGGRFRLVGVVSVAFGCPFEGHVDPGRVAE
                     DVARFVELGADAVTLGDTTGVATPGSVAALFRRLERAHPGLPVIAHFHNTRGTGIANAV
                     AALEAGCRHFDSALGGVGGHPSQIGYGAGLTGNVCTEDLVGLFDAMGVETGLDLDALAA
                     ASRACEEALGRPLHSMVARAGFDRFPTPAATTAA"
     gene            complement(15666..16151)
                     /locus_tag="L6J92_RS06440"
                     /old_locus_tag="L6J92_06440"
     CDS             complement(15666..16151)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024212.4"
                     /locus_tag="L6J92_RS06440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06440"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_194276043.1"
                     /transl_table=11
                     /translation="MQKREGGSDLVPISELLSYRLSRTSSALSRSAALRYRREFDVSLG
                     EWRTIALIAADPTLTLNRLARRAGLDKAQMSRVVRGLVERDLVRRTEGSGRTRQLALTE
                     AGVVLYRGLIAAANERDAAFAAALSPEESGALERALEKLADLALTMEHQERDRLDDT"
     misc_feature    16248..16260
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     gene            16283..17650
                     /locus_tag="L6J92_RS06445"
                     /old_locus_tag="L6J92_06445"
     CDS             16283..17650
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076862.1"
                     /locus_tag="L6J92_RS06445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06445"
                     /product="MFS transporter"
                     /protein_id="WP_243780661.1"
                     /transl_table=11
                     /translation="MVDPSTSTSASTESPGPPAAGAASVDRDATYRTIAWRVMPLLVVC
                     YVVSFIDRTNIGIAEQGLERDLGFGSAVYGLGVTLFFVGFIVFEVPSASLLARFGARRT
                     LVRIMASWGVVTVATALVQDEVTFYVARFLLGVAEAGFFPGALYFLACWFPSARRTRMT
                     AVFFAGVPVSGVLGSLMSGWIMHTFGGVGGLADWQWLFVIEGIPPILLAVAVLVWLVDA
                     PEQARWLSPAQKTAVRADLVADQQRKTGEEKGHGGLRLALRDPKVWIIGLCACGAYTLA
                     NAVSFWTPRIIADAGVGDVLNLGFFSALPPLLGIVVMQIVGRHSDRTLERRWHAALSWT
                     VAACAMAALSLSEGSVVVVVVLLAVLAAAHYSGLTVFYSIPSIYLGERAAATGIAFVTS
                     MGSFAAAASPSLLGFIQARTGSLALGLQISAAIVLLAVVLLLVGVKARDLRERRPG"
     gene            complement(17784..18494)
                     /locus_tag="L6J92_RS06450"
                     /old_locus_tag="L6J92_06450"
     CDS             complement(17784..18494)
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713394.1"
                     /locus_tag="L6J92_RS06450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06450"
                     /product="3-oxoacid CoA-transferase subunit B"
                     /protein_id="WP_243780662.1"
                     /transl_table=11
                     /translation="MNTDRRPAPQETPVPDVRGPQDAPGPLGQDAVAALVARDIPHGAF
                     VNLGIGRPTSVADHLAADSGVVLHTENGMLNMGPAARGDAVDPDLTNAGKVPVTELPGA
                     AYFHHADSFAMMRGGHLDICVLGAFQVSAAGDLANWHTGAPDAIPAVGGAMDLAIGAKQ
                     VFVMMTLFTRSGAPKLVPRCAYPLTGQGCADRVYTDHAVFDITPEGVVVRETFGTGVDE
                     LAGRLDLPLLSPGG"
     gene            complement(18491..19159)
                     /locus_tag="L6J92_RS06455"
                     /old_locus_tag="L6J92_06455"
     CDS             complement(18491..19159)
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020553869.1"
                     /locus_tag="L6J92_RS06455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06455"
                     /product="3-oxoacid CoA-transferase subunit A"
                     /protein_id="WP_243780663.1"
                     /transl_table=11
                     /translation="MTTQLCADADEAVAGVEDGSTVLVGGFGMAGMPVALIDALIRQGA
                     KDLTVVSNNAGNGDTGLAALLAEGRVRKVICSFPRQTDSHVFDGLYRAGRIELEVVPQG
                     SLAERMRAAGAGIGAFYCPTGAGTLLAKGKETRVIDGRPHVLEYPIRGDVALIGAHRAD
                     RMGNLVYRKTARNFGPVMATAATTVVAQVREIVETGALDPETVVTPSIYVDRVVQEGTA
                     "
     gene            complement(19156..20361)
                     /locus_tag="L6J92_RS06460"
                     /old_locus_tag="L6J92_06460"
     CDS             complement(19156..20361)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006635 - fatty acid beta-oxidation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824303.1"
                     /locus_tag="L6J92_RS06460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06460"
                     /product="thiolase family protein"
                     /protein_id="WP_195889889.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 8.9e-05, bitscore:
                     20.9, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDSYLYAAARTPFGRFSGALAGVRPDDLAALAVNGVLAKVPEFA
                     ADGLDDVVWGNANGAGEDNRNVGRMAVLLAGLPTSVPATTVNRLCGSSLDAAIIASRAI
                     ETGDADVVLTGGVESMSRAPWVLPKPHRAYPAGDMTAVSTTLGWRLVNERMPKEWTVSL
                     GEANEQLAERFPIPRRRQDEFAARSHELADAAWNAGFYEDLVVPVPVDGKGGTLGRDEG
                     IRPGSTADGLAALKPAFRPDGVITAGNASPLSDGASAVLLGSRSAAARIGADPLARIAG
                     RGVFALDPQLFGFAPVEAANRALRGAGISWSDVSAVELNEAFAVQALACVDAWGIDPAT
                     VNAKGGAIALGHPLGASGGRLLGTLAHRLKESGGRWGLAAICIGVGQALAVVLENVTEA
                     GR"
     gene            20454..21341
                     /locus_tag="L6J92_RS06465"
                     /old_locus_tag="L6J92_06465"
     CDS             20454..21341
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020553871.1"
                     /locus_tag="L6J92_RS06465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06465"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_194276040.1"
                     /transl_table=11
                     /translation="MELRQVRYFLALAEECHFGRAAARLHVAQPALSQQIKQLERELGT
                     ALFHRSTRHVDLTEAGRDLVGYARALLAEEQRARAHMAELAGGGAGRVSVGFIGTATYD
                     VLPRVSRTVRARLPGISLELHGEVLTPQLLDGLLTGAYDLAVCRPDTAGIAQVRTAPLL
                     TESLMAVLPARHPLAARPVLPLRDLADEPFVIHSSQPRSSMYDRVLSACDRAGFRPSSL
                     VEVGETATLVVFVAAGHGVALVPQSVRSLRLDGVTYVPLAEPEPVDLVLARRTRPDSPA
                     VERVASVIEQCVRG"
     gene            complement(21362..21769)
                     /locus_tag="L6J92_RS06470"
                     /old_locus_tag="L6J92_06470"
     CDS             complement(21362..21769)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973765.1"
                     /locus_tag="L6J92_RS06470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06470"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_194276039.1"
                     /transl_table=11
                     /translation="MLVHEVMSTVVLTIGPAHTLRQAAALMSARHVGAAVVHDPDAGGI
                     GILTERDVLVSVGRGQNPDTEHAHAHTTTDVVFAAPTWTVEEAAGAMTHGGFRHLIVLD
                     GGEPAGIVSVRDIIRCWAPARPRHNAPAVTA"
     gene            complement(21951..22751)
                     /gene="hisN"
                     /locus_tag="L6J92_RS06475"
                     /old_locus_tag="L6J92_06475"
     CDS             complement(21951..22751)
                     /EC_number="3.1.3.15"
                     /GO_function="GO:0004401 - histidinol-phosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207: inositol monophosphatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522878.1"
                     /locus_tag="L6J92_RS06475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06475"
                     /product="histidinol-phosphatase"
                     /protein_id="WP_070390411.1"
                     /transl_table=11
                     /translation="MPDYLDDLRLAHVLADAADAATMDRFKALDLKVETKPDMTPVSEA
                     DKAAEELIRGHLARARPRDSVQGEEFGVAGAGPRRWVIDPIDGTKNYVRGVPVWATLIA
                     LMEAGEGGYQPVVGLVSAPALGRRWWGVLDHGAFTGRSLTSASRLHVSQVSTLKDASFA
                     YSSLGGWEEQGRLDGFLDLTREVWRTRAYGDFWPYMMVAEGSVDICAEPELALWDMAAA
                     SVIVTEAGGTFTGLDGRPGPHSGNAAASNGRLHDELLGYLNQRY"
     misc_feature    23006..23021
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.26"
                     /tool="antismash"
     gene            23068..23679
                     /locus_tag="L6J92_RS06480"
                     /old_locus_tag="L6J92_06480"
     CDS             23068..23679
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973763.1"
                     /locus_tag="L6J92_RS06480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06480"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_224300281.1"
                     /transl_table=11
                     /translation="MPAARESLLDAAYTALARRPWAAVRMVDVAASAGVSRQTLYNEFG
                     SKDGLARALVRREADGYLAGVERALSGPSDPRERLTATAEWMMSAAHDNVLVRALLTGC
                     WNERLPAPALSAVPSSSGVPAQRRADGPLPSPGDFVTLVRDRAVAVLNGGGPLAPPAAG
                     ELARSCELAVRLALSCVAAPPAEGGVADLVRTALPRRLTA"
     gene            complement(23683..24006)
                     /locus_tag="L6J92_RS06485"
                     /old_locus_tag="L6J92_06485"
     CDS             complement(23683..24006)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845570.1"
                     /locus_tag="L6J92_RS06485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06485"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_031033194.1"
                     /transl_table=11
                     /translation="MAWLLVIVAGVLETGFAVCLKLSHGFTRLWPTIAFCAFALGSFGL
                     LTMSLKKLDVGPAYAVWTGIGAAGTAIYGMIFLGDLVSVLKLVSISLVIIGVIGLQLSG
                     SAH"
     gene            complement(24148..25161)
                     /gene="rsgA"
                     /locus_tag="L6J92_RS06490"
                     /old_locus_tag="L6J92_06490"
     CDS             complement(24148..25161)
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0043022 - ribosome binding [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rsgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142295.1"
                     /locus_tag="L6J92_RS06490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L6J92_06490"
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="WP_031033192.1"
                     /transl_table=11
                     /translation="MRRYGKHTDEDDIRTRPHRKGNRPRTHIRPKHEDAAGGLVLTVDR
                     GRLTCLVEDRVVMAMKARELGRKAAVVGDRVALVGDLSGKKDTLARIVRIEERTSVLRR
                     TADDDDPYERVVVANADQLAVVTALADPEPRPRLIDRCLVAAFDGGLTPLLVMTKSDLA
                     PPDELLELYGALDIPYVVTSREGLENGAAAELVREHLDGKITAFVGHSGVGKTTLVNTL
                     VPEDRRRVTGHVNAVTGRGRHTTTSALALPLSSEGGGWVVDTPGVRSFGLAHIDPSRVI
                     NAFPDLVPGTEGCPRACSHDEPDCALDAWVEEGHADPARLYSLRRLLSTRERREGD"
ORIGIN
        1 cgaccgtcaa ggagcccacc gacgtctccg aactggtgac caagcacaag cccggcgagg
       61 acgtcgactt caccatcgtg cccgccaagg agcaggccgc cgcggagaag gagcgccgga
      121 cgcccacgaa gacggagaag gtcacggtca ccaccgagac ctcggacgac gggggcgagg
      181 cgcgcgccat cgtggggatc tccgccggga ccgatcacac gttcccgttc gacatcgaca
      241 tcaagctggc cgacgtcggc ggcccgagcg ccggtctgat gttcgccctc ggcctctacg
      301 acaagctcac gccgggcgac ctcaccggcg gcaagttcgt cgccggtacc gggacgatcg
      361 acgacaccgg caaggtcggc ccgatcggcg gcatcggcat gaagaccatc ggagcgcacg
      421 acaagggcgc ccagtacttc ctgacgcccg ccgacaactg cgcgaccgcc gccgaggaca
      481 cccccgacgg gctcaccctc gtgaaggtgg acaccatcga cgacgccctc ggcgcgctca
      541 aggacatcag ctccgggaag accgacgacc tgccggagtg cacgaagggg tagccacccg
      601 gcagccgtcc ggcccggcta ctccgcgaag gtcgccgtca aggcctgcgc cagaccaggc
      661 accaggtcgg aacccgtgag gacctccgtg gcggagtcct tctcccgcag ccgcagggcc
      721 gagtcccggg caccgtcgcg caggaccgcg accgtcatcc ggacctcctg ccgttccggg
      781 tgctccgcca cccagcgcgc cagcttcgtc tcgtccagac cctccggaac ctgcgcctcg
      841 gcggacggcg gcagcatcag gcgctccacg gcgagcgcgc agccgaccac cgcgtcgggc
      901 caggcgatgg tgcccaggaa ctcgtcgagc ggctgggccg tgggaatctc gtcctgctcg
      961 atcggagtca ggccggagct ctccggctcg tcctgcagac cgagccggtc cgcgagcgag
     1021 ggctgatcgg ccctcagacg tgcggtgtcg accagtgcga agaggcgtgc gggctggtcc
     1081 cagccgagtc ctgagacgta ctcgtcgatc tcgagtacgg cccgggtgag ggggctcgcc
     1141 gccatggggg tgttggacat agtcacaatc ctgcctcgtt catggcccga atcgggaacc
     1201 gagtaaacgt tgagtaagtt gcataagtgt gggcccacga tcacgcgggc gcacgggggg
     1261 cccgcgaacc cgagggcctg acgtctcaac agcgaacttt cgaggtgcgc accttggctt
     1321 tccagatgcc ggaccgcggc ggaggccccc cgacggggcc gcggatcaga gtgggccgcc
     1381 cgtcccggcg cgtccgaacc ctgctgctga cacttggtgt cctggccgtg ctggccatgg
     1441 cgttcaccat gttcgcggga ttctggacgg actggctctg gtaccggtcg gtccactact
     1501 cgtcggtgtt cacgacgacc ctgtggacca agatcgggct cttcttcgtc ttcggcctgc
     1561 tgatggcgct cgccgtcggg ttcaacatct ggttggccca ccgcctgcgc ccgccgctga
     1621 gcgccatgtc gatggagcag cagaacctcg accggtaccg catgggcatc gccccgtaca
     1681 agaagtggct gctgctcggg atcaccgccc tggtcggcct gatcgccggc gcctcggcgt
     1741 ccggtcagtg gcgcacgtgg ctgatgtggg tcaacggcgt gcccttcggg cagaaggacc
     1801 cccagttcaa actggacgtc tccttctacg ccttcgacct gccctggtac cggttcctgc
     1861 tcggcttcgg cttcgcagcc gtgatcatct ccgtgatcgc cgccgcgctc acccactacc
     1921 tgtacggcgg gctccgcgtc accagcccgg gcgcgcgcgc cacggccgcg gccaccgggc
     1981 acctgtcggt gctcatcggc gtcttcgtcg ccctcaaggc ggtcgcctac tggctcgacc
     2041 ggtacggcct ggccgtgaag tccagcgact tcaaggccac ggacaactgg acgggcctca
     2101 ggtacgtcga cgccaacgcc tacctgccgg ccaagacgat cctgttctgc atcgccgtca
     2161 tctgtgcgct gctcttcttc gccaccctgt ggcggcgcac ctggcagctg ccggtgatcg
     2221 gcttcggcct gatggtgctc tccgcgatcc tcatcggcgg cctgtacccg gcgctcgtcc
     2281 agaagttcca ggtccagccg aacgagcagg ccaaggaagc gccgtacgtc gagaagaacc
     2341 tcgcggccac acgcgacgcg tacggcatcg agggcaccca ggtcaccgag tacgcgggca
     2401 agagcgagac caaggacaag accaagctcc gtggcgacgt ggacgccgcg gcgtccatcc
     2461 ggatcatgga cccgaacgtg gtctcgccga ccttccagca gctccagcag atgcgcaact
     2521 actacgcgtt cccgaccaac ctggacgtgg accgctactc gaaggacggc aaggaccagg
     2581 acaccgtcat cggcctgcgc gagctgaacc tggcgggcat tccgaagaag aactggatca
     2641 acaaccactt ccgctacacc cacgggtacg gagtggtcgc cgccaagggc acggcggtcg
     2701 actccgaggg ccgtccggtc ttcaccgagt cggacctgcc gtccaaggga gacctcggag
     2761 agtacgagca gcgggtctac tacggcgaga agaccaccac ctactcgatc gtcggcggcc
     2821 cccagaagga gatcgactac tcggacgaca ccggggagaa gaccttcagc tacaagggcg
     2881 acagcggcgt cgacctgtcg aacgcggtca accgcgcggc gtacgcggcg gcgttcggcg
     2941 agccgcagat cctgtactcc ggcgcgatcg gagacggctc gcggatcctg tacaaccgca
     3001 cgcccaagga gcgcgtcgag gcggtcgccc cgtggctgac catcgacggc gacgcctacc
     3061 cggcggtcgt ggacggccgg atccagtgga tcgtcgacgc ctacacgacg acgaacggct
     3121 atccgtacgc ctcccgcacg acgctgggcg acacgaccgc cgactcgctg acggcgaaca
     3181 acaactcgcg cgcggtggtg gcccaggaga accaggtcaa ctacatccgc aacagtgtca
     3241 aggcgaccgt cgacgcctac agcggtgacg tcaagctcta ccagtgggac accaaggacc
     3301 cggtcctcaa gacctggatg aaggcgttcc cggacacggt gcaggacaag ggcgagatct
     3361 ccaaggagct gatggcgcac ctgcgctatc cgcaggacct gttcaaggtc cagcgcgagc
     3421 tgctcacgcg ctaccacgtg aaggacgcca acacgttcct cagcggcagc gaggtgtggc
     3481 aggtcccgga cgacccgacg aacaagtcga gcgactcggt accgccgtac tacctgagca
     3541 tgaagatgcc cgaccagaag cagcaggcct tctcgctgac gacgacgttc acacccaacg
     3601 gacgtgacaa cctcagtgcg ttcatggccg tcgacgccga ggcggggacc agcgactacg
     3661 gcaagatcag aatcctgaaa ctgccgacca gtacgaccgt caacggaccc aaacaggtcc
     3721 agagccagtt gaactccgag caggacatcg ccgagaccat caggctgctg agaggcggcg
     3781 actccgaggt cgagtacggc aacctgctga cggtgccggt cgacggcgga ctgctgtacg
     3841 tcgaaccggt ctacgtccgc ggtggcgacc tcaagtaccc gctgctgcgc aaggtgctgg
     3901 tgagttacgg aggcaacacg gccttcgaga acacgctcga cgaggccctc agcaaggtct
     3961 tcggagcaca ggccgccgag aacgagcagc caccggacga gggcgacgac acgaccgagc
     4021 cgccacccac gtcgaccaac ccgacggtca aggaagcgct gggtgacgcg cagaaggcct
     4081 tcgacgccgg gcagaaggcc ctggaacaga aggacctggg cgcgtacgcc gaggcgcaga
     4141 aggacctgga ggaggccctg cagcgggccg aggacgccca ggccaaggcc gaccagggaa
     4201 ccggcaagaa cggtgacgag aacggtggtg gtgacaccgg cggcggatcg gacacgggct
     4261 gaccgtccgg tcgtgcaggg gccggccttc gggctggtca aggcccatcc cgcgccgtgc
     4321 tagggttgtg aacacaacgg cgcggggtgg agcagctcgg tagctcgctg ggctcataac
     4381 ccagaggtcg caggttcaaa tcctgtcccc gctactgaag tcgtggctgt gtgcgacgac
     4441 cacaaaggcc cggattccga aagggatccg ggcctttgtg atgtgcgaac gcatgtaccg
     4501 ggagaaccga cggccgcgcc gccaggggga gttggactca tctgtgtttg acttgtctcc
     4561 ctgtgggcat gtcgacaaaa cgctgaagtg acctcactga ctgcggtata ccggatgtac
     4621 cgaggttgca ggtggtgcga cgatggacgt tatgggggac atggcaaatc tgttcgggac
     4681 agggcgtttt gcccagccgt ccggtcagga ggaggccacg gacgaggccc aggaagcggc
     4741 cgacgaggca gccgaggaag tacggctgct gctcgccgtc gacggcggtg acgccgaggc
     4801 catgagcgtc ctcggcgcga tgctgctgcg ccgcggcgac ttcgagggtg ccgagtccca
     4861 tctgcgtgcc gccaccgcgg ccggtgaccg ggccgccgcc aacaacctgg gtgtcctgct
     4921 gcaccagcgc ggctacgcgg acgaggcggc cggctggtgg cgcatcgccg ccgtcgccgg
     4981 gtccgtaccg gccgcccacg cgctggggcg gcacttccgt gagcgcgggg acgagccggc
     5041 cgccgagtac tggctgtgcc agtccgccga acagggccac gtactgggcg cctacgccct
     5101 cgccgacctg ctggagcacc gcggcgacga caccggggcc gagcggtgga tgcgggccgc
     5161 ggccgagcgc gggcaccggg aggccgcgta ccggctggcg cggacgctgg accggcgggc
     5221 gggggaggcc ggatgtgccg ggcagtccgg acggcgggcc gggcaagggc gcgacggagg
     5281 ccgcgacggc gggcgggcgg gcgcctccgg gggtgacttg ggcgccgact ccgggaccgg
     5341 cgaggtcgag cagtggtacc ggcaggcagc cgcgcgcggc caccgtcggg ccgcgctgca
     5401 gctcggggcg atcctggaga agcggggcga gctcaaggag gccggccgct ggtacctcac
     5461 gtccgccaag gacggcgagg cccgtgccgc ctgcgcgctc ggcttcctgc tgcgggacgc
     5521 cggggacacc gagagcgccg cagtgtggtg gctgcgcgcc gcccaggacg gcgacggcaa
     5581 cgccgccaac gccctgggcg cgctgcacgc cgagcgtggc gagacccaga ccgccgagcg
     5641 ctggtaccgg gccgcgatgg acgccggcga cgacaacggg gcgtacaacc tcgggctgct
     5701 ctgcgccgag cagggccgca ccgcgccggc cgagcagtgg taccggcggg ccgcgtacgc
     5761 cgggcaccgg gaggcctcca acgcgctggc cgtcctgctg ctgcgtgccg gggaccggac
     5821 cggcgccgag ccgtggttct ccaaggccgc cgaggccggc agtgtcgacg cggccttcaa
     5881 cctcgggatc ctgcacgccg ggcggggcga ggagaaggtg gcgctgcgct ggtacgagcg
     5941 agccgcggcg gccgggcaca cggaggcggc actgcaggtc ggcatcgcgc ggctgcgggc
     6001 cggcgacgag cgcgacgcgg agcggttcct gcggtgcgcg gcggggggcg gcagcgcgga
     6061 ggccgcctac cggctcgcga cgctcctcga cgcgcgccga ccgcccgcgc ccgcacacga
     6121 actgggcgag ccggagcagg ggaagtccga gtgcgaggag tggtacgagc gggcggcctc
     6181 ccaggggcac cgccgggccc aggtccgggt cgggatgctg gccgctgcgc ggggcgacgt
     6241 ggtggaggcg gcccggtggt accgggaggc ggccgaggcc gggtcccgca acggcgcgtt
     6301 caacctgggg ctgctgctgg cccgcgaggg gagcgagccg gaggccgtgg tgtggtggcg
     6361 cagggcggcc gacgcgggac acgggcgggc ggcgctgcgg ctcgcgctgg tgttcgcgcg
     6421 gcggggagag ctggccgagg ggcagcggtg ggcggacctc gcggtgtcgc tggggccggt
     6481 ggaggtgggc aagcgggcgg cgcggttgcg ggacgcgctg cggcaggagt tgtcggcgtg
     6541 acgcgtgacg cgtgacgcgt gacgctgcgc tgggcttggg tgcctttgtg aggtgcctgg
     6601 tgcttgtgcg gtgcccggtg ctggtgccgg gcgggggtgg gtcgcgcggc ccggcgctga
     6661 ggggtgccgc tgcgcccacc cgtgccgccc tgcggcacga ttgcccgcag ctacgcgcgg
     6721 gactgcccgc agccatacga ctgagaccgg aatcctttgg attccggtct cagtctttca
     6781 gtagcgggga caggatttga acctgcgacc tctgggttat gagcccagcg agctaccgag
     6841 ctgctccacc ccgcgtcgat gaacagaaca ctacgtcagc ccgaaggcga gaagcaaatc
     6901 cggggctcac gccgtcgcgc agttcgggca ggtgccgcgg tacgtgacct cgacgtccga
     6961 gacggtgaag ccgaagcgct ccgagtcggg gaggtcggcc agcgggttgc cggtcgggtg
     7021 gacgtcgcgg atcgcgccgc accgggcgca gaccaggtgg tggtgcggct ggtgcgcgtt
     7081 cgggtcgtac cgcttggcgc gcttgtccgt cgcgacttcc agcacctcgc cgagcgtgac
     7141 cagctcgccc agggtgttgt agaccgtcgc cctggagatc tcggggagct tgtccacggc
     7201 ccgggaatgc acctcgtcgg ccgtcatgtg gacgtgttcg ccgtcgagga cctcggccac
     7261 cacgcgtcgc tgcgcggtca tgcgccatcc gcgtccacgc aaccgttcca gtaggtcact
     7321 catgcgaacc agcctagcag taggggggac caggtcccga acaggtgtga ctttggagcc
     7381 ttacttgact tagacattgt ccattgtagg atcgactacg gcattagcca agggacaggt
     7441 tttacgcagg attggcgcag gaggcgtacg tgactcaggg accgctcact acggaggccg
     7501 gtgctccggt agccgacaac cagaacagcg agaccgcggg cgtcggcggc cccgtgctcg
     7561 tccaggacca gctgctcctc gagaagctgg cccacttcaa ccgtgagcgc atcccggagc
     7621 gcgtcgtgca cgcgcgcggc gccggtgcct acggcacctt cacggtcacc gccgatgtca
     7681 cccggtacac gcgcgccgcg ttcctctccg aggtcggcaa ggagacggag accttcctcc
     7741 gcttctccac cgtggccggc aacctgggcg cggcggacgc cgtccgcgac ccgcgcggct
     7801 tcgcgctgaa gttctacacc gaagagggca actacgacct cgtcggcaac aacaccccgg
     7861 tgttcttcat caaggacgcc atcaagttcc ccgacttcat ccacacccag aagcgcgacc
     7921 cctacaccgg gtccacggag atggacaacg tctgggactt ctggggcctg tcgccggagt
     7981 cgacgcacca ggtgacctgg ctgttcggcg accgcggcat cccggcgtcg taccgccaca
     8041 tggacggctt cggctcgcac acctaccagt ggagcaacgc ggccggcgag gccttctggg
     8101 tcaagtacca cttcaagacg gaccagggca tcaagaccct cacgcaggcc gaggccgaca
     8161 agctcgccgg tgcggacccc gactcccacc agcgcgacct gcggcaggcc atcgagcgcg
     8221 gcgacttccc gtcctggacc gtcggcgtgc aggtcatgcc cgtcgccgag gcggcgcagt
     8281 accgcttcaa cccgttcgac ctgaccaagg tgtggccgca cgcggactac ccgatcgtct
     8341 ggttcggcaa gctggagctc aaccggaacc cggagaacgt cttcgcggag gtcgagcagt
     8401 cgatcttctc gccgtcccac ttcgtgcccg gcatcgggcc gtccccggac aagatgctcc
     8461 agggccgcct cttcgcctac ggcgacgccc accgctaccg cgtcggcatc aacgccgacc
     8521 acctgccggt gaaccgcccg cacgccaccg aggcccgtac caactcccgt gacggccacc
     8581 tgtacgacgg ccgccacaag ggcgcgaaga actacgagcc gaacagcttc ggcggcccgt
     8641 tccagacgga ccgggccctg tggcagccgg ttgcggtctc cggtgccacc ggcgagacgg
     8701 aggccccgtc gcacgccgag gacaacgact tcgtccaggc gggcaacctc taccggctga
     8761 tgacggacgg cgagaaggag cggctgatcg agaacctggc cggtgccctc tccgacgtct
     8821 cgcgcgacga gatcgtcgag cgtgcggtcg gcaacttccg tcaggccgac ggtgacttcg
     8881 gcaagcggct ggaggccgcg gtccaggccc tgcgcggctg acagccgaca ctggaccgct
     8941 tgccgtagcg gcgggccgga ttcccggggg acggggatcc ggcccgttgg ccgttcacgc
     9001 gccggtcacg ccccggcggt cccggccggg gcaggacgcg gttcctcggt gggcaggggc
     9061 agccgggtga ccgcccggcg gtactcggcg acgatgcggt ccaccacctc ccgcgcgggc
     9121 agcaccgcgt cgaccagccc cgcggactgg cccgcctcca ccttgccggt gtccaccagg
     9181 ccgtccagcg cggcgtcctt cagactcgcg gaggcgaacg cgccccggcg cacgtccagc
     9241 tccgtcccgt cctcctccag ccgggtcatc cggcgggtga agtcgttgtc cagggcgcgg
     9301 atcgtgccga ggccgcggcc gaccgtacgg gtggagtcga ctccggcggc gacgacggcc
     9361 gccttgtagc cggggtgcac ggtggcctcc tcggtggcga ggaaccgggt cccgaactgg
     9421 gcgccgtccg cgccgagggc gagcatcgcg gccaggccgg cgccgtccgc gacccctccg
     9481 gaggcgacga ccggcacgcc gggcacggcg gagaccaccg cgcgcaccag cacctgcgtg
     9541 gcgaccatcg cgggcggcgg gtgcccgccg gcctcggcgc cgacgacgac gagcccgtcc
     9601 actccggcgt cggcggcctt gcgggcgtgc tcgaccccgg cgacgacgtg caggcagacg
     9661 gtgcccacgt cgtggaagcg gtccaggtag cggcgcggtc cgccctggga ggcgatcagc
     9721 accggcggac gccgggccag cagcagttcg acgacctcgt cggcgcccgc gcggtagagg
     9781 ggcaggttga ccgcccaggg gcggtcggtg ccggcggccg tctcgtccag ggtgcgggcg
     9841 aggtcgggca ggcgcatcgg gcccgcggcg accacgccga ggccgccggc ccggctgacc
     9901 gccaggggca gcgcggagct ggaggacgcc caggacatgc cggcctgcac gacgggcaga
     9961 tcgatgccga gcagctcggt gaggggcgtg gcgatacggg tcatgccgcg gccccggtgc
    10021 cgtcgtggcc cagcagggtg cgggcgtggg cggcgaggcg gttcttctgc accttggagc
    10081 tggcggtcat accgatgccc tcgaagccgt ccacgatgcg cagatgcctg ggcaccttga
    10141 agcccgccat gcgggtcctg gcccagtcga tcagctcctg ctcggtgggg ccgggaccgg
    10201 tgagtacgac gaaggcgaac ggcacctcca tcagccgctc gtcgggcacg ccgaccacca
    10261 ccgcctgccg tacccccggg tggcggtgca ggacgtcctc gacgtcggcc ggggcgacgt
    10321 tctcgccgcc gacccggatg atgtccttgg tacggcccgt gaagtgcagc cggccggacg
    10381 cgtcgaggac gccgacgtca ccggtggcga gccagccgtc cggatcgacg gcggcggcgg
    10441 tggccgcggg gtcgtcgagg tagccctgca tcacgttcca gccgcggacc aggatcgagc
    10501 cgggttcgcc gggcccgcag tcgcggctgc cgtccagcgc ccggatgcgc acctcgacgc
    10561 ccggttccgc cagcatcgcg ccggaggccc gtacctcgtc cggctcccac cagcaggact
    10621 gggcgacgtt cggggacgcc tccgacaggc cgtacccggc gacgcactcg gccgcgccca
    10681 gctcgtcgat gacccggcgg atcacggtgg gggaggcggc gacccaggcg ccgcgcagcc
    10741 gcagcgcgcg gtgggcgagg tcggggtggt tgagcagcag cagggcgatg gtgtcgttgc
    10801 cggagaagtg ggtgcagcgc tcctcctcca gcagccgcag cgcctccgcg ggctcgaagc
    10861 gcggcatggt caccagcgtc gtggcgtgct ggaggcaggc gagcacggac agggtgctgc
    10921 cggcgacgtg gaagaagggc cgggcgctgt ggaagcggtc ccccggacgc aggccgagcc
    10981 gggcgcccga gaagaagccg tcggcgcaca tgctgcggtg ggtgagcagg acgcccttgg
    11041 ggcgtgcggt ggtgccggag gtgtactgga cgagcaggac gtcgtccggg gtcccggtgg
    11101 cgggcacctc gccggtgccc cgggccagga actccggcca cggcgtggcc cagccgggca
    11161 ccgcgtcgcc gcacaccacg acccgctcca gggcgggcag ggccggacag gtgggcgtgg
    11221 cgtcggcgcc gatgccgatc tcgcgcagca ccgcgtggaa gtcgacgttc agcacgcggt
    11281 cggcgacgaa gagcgtgccg acccgggcgt gggccagcgt gtgccggacc tcgtcggcgc
    11341 tgtaccgggt gttgaccggc acggtcaccg cgccgaccga gcccagcgcg acgaacaggg
    11401 cgacccagcg cggcccgttg cccaggcaga ggccgacccg gtcgccgcgg ccgatgccgg
    11461 cggcggtcag cgccgcccgg acgcggacga cctcggcggc gaggtcgcgg taggtgatcc
    11521 gctccgcggc ggtgaccacg gcctccacgt cgggggcgag cagcgcggca cgctccagtg
    11581 ccgcgtgcgc ggtcaggggg catgcggcgg cgagatcgag atccgtcact tctcttcctc
    11641 ctctgtactg ccgtggccgt ccgtactgcc gtggccgtcc gtactcccgg cgccgtccgt
    11701 accgccggga ccgccggcgc cgccggtgcc gccttgaccg ccgtcgcggc ggcgggcgaa
    11761 gcggtcgacg ccctcgcgcc agccgccgtc cgcgaggcac tgctcgatgg ccgccatctc
    11821 gatccggatg ccccggtcga ggtcggtctc gccgccgagg tcgacggcgc gcttggtcag
    11881 cgccatggcc agcggcggcg ccccggcgat cgaggcggcg atctcctcgc cggcccgggc
    11941 caaccggtcg cccggcacga cccgggtgac gacgcccagg tcggcggcct cggcggccgg
    12001 catgacccgg ttggtgaaca gcagctcctt ggcgcggcgc cgcccgatga cgcgctgcag
    12061 gcgctgggtg gcgccgaccg ttccccagtg tgcctcggga aaccggaagg tggtgtcctc
    12121 ggcggcgacg gcgaagtccg ccgccagcgt gatctcgccg ccgctgccca cgaccgcgcc
    12181 gtgcaccagc gcgacgacgg ggcggcggca gcgctccacg gcgtcgtagg cggcgaagga
    12241 cgcctggcgc cggcggcgca cccaggcggc gtcccggccg gcccgctcct tgagatcggc
    12301 ccccgcgcag aacgccgggc cctcggcgga cagcaggacg acccgtacgt cgtcgtcggc
    12361 gtcgaggtcc tcgaagacgg cccgcagccg caggcacatc tccaggtcga cggcgttgcg
    12421 ggcgcgcggc cgggcgagcc gtacgcgtgc gacgccgtcg gcgacgtcgc accgtacccg
    12481 gaccgtctcc gcgtccggtg tcccggcgcc cggggtgtcc gcgcccggcg tctcagcgcc
    12541 cggtacgtcc gcgcccggcg tctcagcgtc cgccatcctg gatcaccccc gctgcccgca
    12601 gctcgtcgat ctcctcgtcg ccgagaccgg ccaggtcggc cagtacggcg tcggtgtcgg
    12661 cgcccagcag cggcggggcg ccggccacgg gcggggcacc gtcggtctcg cgcagcgggg
    12721 tgcgcagggc acggaaggtg ccctcggtgg ggtgctcgaa ctcggtgacg acgccgcggg
    12781 cccgcgcgtg cggatcggcc agcgcctcgc ggaccccgcg caccgcaccg gccgggacgt
    12841 cggcggcgag cagctccttc agcagcgggt cgcgctcccg ccgggcgatc gcggcgcgca
    12901 gcgcggtcat cacgtcctcg cgccgggcga tccgcccggc gttgtgccgc agctccgggt
    12961 cggcggcgag gccgtcgagg ccgaggacct cgcacagcgg cacccagtgc tggtcgctgc
    13021 cgctgatgtg cagccagccg ccgtcggccg tctcgaacgc cgcggagggc acccggccgg
    13081 ggtgctgcgt gccggtgcgc gcggggtcct cgtccagcgc gaagagccgg gccgcgttga
    13141 gggcgtgcag gctgagctgg acgtccatca tcgatacgtc gaagtggcgg ccccggccgc
    13201 tgacgccgcg cccggcgagg ccggtgagca cggcgatggc gacccagagc ccggaggtca
    13261 tgtcggcgac cgggatgccc gtcttgctgg gcggcccgtc gggttcgccg gtcatcgcca
    13321 tcacgccgga cagcgcctgg aagacggtgt cgtagccctt gcgggtgcgg tcggggccgc
    13381 tctgcccgaa gccggtcgcg gagacgtaga ccaggccggg attgcccgcg gcgagatcgt
    13441 cgtagccgag accgagccgg tccatcgcgc cgggcaggaa gttctccacc acgacgtccg
    13501 cgcgggcggc gagccggcgg gcgacgtccc ggccgcgggg gtccttgagg tcgagggcga
    13561 cggagcgctt gccccggttg aaggcgaaga agtaggcgct ctcaccgtgc ggcagcctgg
    13621 gctcgaagcc gcgggtctcg tcgccgccgc ccggccgctc caccttgacg acggtggcgc
    13681 ccagctcggc gaggatctgg gtggccatcg gggccgccag cacccgggag aagtccagga
    13741 cggtgacgcc ctccagcggg cggggtgcgg tcggcgcgct caccgacgga acgcccgcat
    13801 cagcgcgttg acgtcctgcc ccgcccgcat ggcggcctcg gtgggcaggt cggcgacgcg
    13861 gtagaagagg tccttggccg cgcggatcgc ccgcggttcg acggcggccc accgttcggc
    13921 gatctccagc gcggcgccct ccacctcgtc cggctcgacc acccggttga ccaggccgtg
    13981 ctccgcggcc tcgacggcgc tcagcagccg gccggtgctg accagttcga aggcgagctt
    14041 gcggcccagg tggcgctgga gcccggtcat cacgagggcg ggcacgatgg agtgccgcag
    14101 ctccggatag ccgaacttca ggtcggtccc ggccacggcc atgtcggcgc cgatcgccag
    14161 tccggccccg ccgcccaccg cggcgccgcg cacggcggag acgaccggcg tgcccatgtc
    14221 ctgcatctgc gtctggagcc gcgcggtgag cgccgcccgc tccagtacgg cgtccggctg
    14281 gtccggggtg agcccggaga actcggagag gtcggcgccc gcgcagaagg cccggcccgc
    14341 gccggtgagg acgacggcac ggacaccggc gtccccctcg gccgcggtga gggcgtcgct
    14401 cagcgcccgg gtcagggcgg tgttcagcgc gttgagcttg tcggggcggt gcagggtcag
    14461 gacgcggacg gcgccgcggt cctcgacgag cagcacgtcg gcggccgggt cgctcggggc
    14521 ggccggccgt ccgctggtcg tgacggtcac gtgggatctc ctcgttccgg agaaagtggg
    14581 gcggcagtgg aagggcgggt gcgcgggcgg tcaggccgcc gtggtcgccg ccggtgtcgg
    14641 gaagcggtcg aagccggccc gcgccaccat gctgtgcagc ggccggccca gcgcctcctc
    14701 gcaggcccgt gaggcggcgg ccagggcgtc caggtcgagg ccggtctcga cgcccatcgc
    14761 gtcgaagagg ccgacgaggt cctcggtgca gacgttgccg gtcagcccgg cgccgtagcc
    14821 gatctgcgac ggatggccgc cgacgccgcc caaggcgctg tcgaagtgcc ggcagcccgc
    14881 ctccagggcg gcgaccgcgt tggcgatgcc cgtaccgcgc gtgttgtgga agtgggcgat
    14941 caccggcagc ccggggtggg cccgctccag ccggcggaac agcgcggcga cggagccggg
    15001 cgtggcgacg ccggtggtgt cgcccagcgt cacggcgtcc gcgcccagct cgacgaagcg
    15061 ggcgacgtcc tcggccaccc ggccggggtc gacgtgtccc tcgaaggggc agccgaaggc
    15121 gacggacact acgccgacca gccggaaccg gccgccggcc agctccgtca tctccgccac
    15181 ccgatgccac tgctcctcgc gggtggagcg caggttgcgc tgcgtgtggc tctcgctggc
    15241 ggacaccagc aggctcagct cctcggcgcc ggtgccccgg ccgaggtcct ccagggcgcg
    15301 tcgtacggcc ctggggttgg ggcaggtcgc cttgaacgcc acgccggggc ggtgggtgat
    15361 gcccgccagc acctcactgg cgtccgcgaa ggcgggcacc caccgcggat ggctgtagct
    15421 cgtcgcctcg acgcggcgga agccggccgc ggcgaaggac tccagcaggc tgatcttcgt
    15481 gtcggtcggc acgaacccgg gttcgtgctg gagaccgtcc cgggcgaagc actcgcagat
    15541 cgtgaccgcg tcggtcatcg ggccacctcc tcgtggatga cccgaccaga atcacccccg
    15601 ggtgttgata aagtcaacac cggtcgatcg ctggtcgatc gctgggcggc ccgtcccgtg
    15661 cgtcctcacg tgtcgtcgag gcggtcccgc tcctggtgct ccatggtcag cgcgaggtcg
    15721 gccagcttct ccagggcccg ctccagcgcg cccgactcct cgggcgagag ggcggccgcg
    15781 aacgcggcgt cgcgctcgtt ggccgccgcg atcagtcccc ggtacagcac cactccggcc
    15841 tcggtcaggg ccagttgccg ggtgcgcccc gagccctcgg tgcggcggac cagatcccgc
    15901 tccaccagac cccgcaccac ccggctcatc tgcgccttgt ccagtccggc gcgacgggcg
    15961 agccggttga gggtcagggt cgggtcggcc gcgatgagcg cgatggtgcg ccactcgccg
    16021 aggctgacgt cgaactcgcg ccggtagcgc agtgccgcgc tgcgcgacag cgccgacgac
    16081 gtgcgcgaca accggtagga caacagctcc gagatcggga cgaggtctga gccaccctca
    16141 cgcttctgca tggcggacat cgtatcgccg gcgacttcct ccgatccctc caaggtgttg
    16201 actttatcaa cacctcaggt cgagactcgc accggtcgcg gccctctgcg accctgtcac
    16261 ttcacgcaag gagtcgtaca tcgtggtcga cccctccact tccacctccg cgtccacgga
    16321 gtccccggga ccgccggcgg ccggcgccgc gtccgtcgac cgtgacgcca cctaccgcac
    16381 catcgcctgg cgcgtgatgc cgctgctggt cgtgtgctac gtcgtcagct tcatcgaccg
    16441 caccaacatc ggcatcgccg agcagggtct cgaacgcgac ctcggcttcg gctccgccgt
    16501 gtacggcctc ggcgtgacgc tgttcttcgt cggcttcatc gtcttcgagg tgccgagcgc
    16561 gagcctgctc gcccggttcg gtgcccgccg gaccctggtc cgcatcatgg cgtcctgggg
    16621 tgtcgtcacc gtcgccaccg ccctcgtgca ggacgaggtg accttctacg tcgcccggtt
    16681 cctgctcggc gtcgccgagg ccggcttctt ccccggggcg ctgtacttcc tggcctgctg
    16741 gttcccctcc gcgcggcgca cccggatgac cgcggtgttc ttcgcgggcg tgcccgtctc
    16801 cggggtcctc ggctccctga tgtccggctg gatcatgcac accttcggcg gcgtcggcgg
    16861 cctcgccgac tggcagtggc tgttcgtcat cgagggcatc ccgccgatcc tgctcgccgt
    16921 cgccgtcctc gtctggctcg tcgacgcgcc cgagcaggcc cgctggctct ccccggccca
    16981 gaagaccgcc gtccgcgccg acctggtcgc cgaccagcag cgcaagaccg gcgaggagaa
    17041 ggggcacgga gggctgcggc tcgcgctgcg cgaccccaag gtgtggatca tcggcctgtg
    17101 cgcctgcggc gcctacacgc tcgccaacgc cgtctccttc tggaccccgc gcatcatcgc
    17161 cgacgcgggg gtgggcgacg tcctgaacct gggcttcttc tccgcgctgc cgccgctgct
    17221 cggcatcgtc gtcatgcaga tcgtgggccg gcactccgac cgcaccctgg agcgccgctg
    17281 gcacgcggcg ctgagctgga cggtcgccgc ctgcgccatg gcggcgctct cgttgtccga
    17341 ggggagcgtc gtcgtggtcg tcgtcctgct ggccgtgctg gccgccgccc actactcggg
    17401 gctcaccgtc ttctactcga tcccctcgat ctacctcggc gagcgcgccg cggccaccgg
    17461 catcgccttc gtcacctcga tgggttcctt cgccgccgcg gcctccccgt ccctgctcgg
    17521 cttcatccag gccaggaccg gcagcctcgc tctcggcctg cagatcagcg ccgccatcgt
    17581 gctgctcgcc gtcgtcctgc tcctcgtcgg cgtcaaggcc cgcgacctgc gcgaacgccg
    17641 cccgggctga cggccggacg gcgttcgcgg cgccttccgc ggggcgccac ccgcgcgacg
    17701 ccttccgcgg ggcgccaccc gcgagacgcc ttccgcgggg cccctccgcg ggacgtcctt
    17761 cgcggggcgc cctccgcgcg gtgtcagccg ccgggcgaca gcagcggcag gtccaggcgc
    17821 cccgcgagct cgtcgacgcc ggtcccgaag gtctcccgca ccaccacgcc ctccggcgtg
    17881 atgtcgaaca ccgcgtggtc ggtgtagacg cggtcggcgc agccctgccc cgtcaggggg
    17941 taggcgcacc gcgggaccag cttgggcgcg ccggacctgg tgaacagcgt catcatgacg
    18001 aacacctgct tcgccccgat cgccaggtcc atggctccgc cgacggcggg gatggcgtcg
    18061 ggtgcgccgg tgtgccagtt ggcgaggtcg ccggccgcgg agacctggaa ggcgcccagg
    18121 acgcagatgt ccaggtggcc gccgcgcatc atggcgaagg agtccgcgtg gtggaagtac
    18181 gccgcccccg gcagctcggt gacgggcacc ttgcccgcgt tggtgaggtc cgggtcgacc
    18241 gcgtcgccgc gggccgcggg ccccatgttg agcatgccgt tctcggtgtg cagcacgaca
    18301 ccggagtcgg ccgccagatg gtcggcgacc gacgtcggcc ggccgatgcc gaggttgacg
    18361 aaggcgccgt gggggatgtc gcgggcgacg agggcggcga cggcgtcctg gcccagcgga
    18421 ccgggtgcgt cctgcggacc gcgtacgtcc ggaacgggtg tctcctgcgg ggcgggtcgt
    18481 cggtcggtgt tcatgcggtc ccctcctgca ccactcggtc gacgtagatg ctcggcgtga
    18541 cgacggtctc ggggtcgagc gcaccggtct cgacgatctc gcggacctgc gcgaccacgg
    18601 tcgtggcggc ggtggccatg accggcccga agttgcgggc cgtcttgcgg tagacgaggt
    18661 tgcccatgcg gtcggcccgg tgggcgccga tcagcgccac gtcgccccgg atcgggtact
    18721 ccaggacgtg cgggcggccg tcgatgacgc gggtctcctt gcccttagcc agcagggtgc
    18781 ccgctccggt ggggcagtag aaggcgccga tgccggcccc ggccgcccgc atccgctcgg
    18841 ccaggctgcc ctgcggcacg acctccagct cgatccggcc ggcccggtac agcccgtcga
    18901 agacgtggga gtcggtctgg cgggggaagg agcagatcac cttgcggacc cggccctcgg
    18961 cgagcagcgc ggccagcccc gtgtcgccgt tgccggcgtt gttggacacc acggtcaggt
    19021 ccttcgcacc ctggcggatg agggcgtcga tcagggcgac cggcatcccg gccatcccga
    19081 agccgccgac gaggacggtc gaaccgtcct ccacaccggc caccgcttcg tcggcgtcgg
    19141 cgcacagctg cgtggtcatc ggcccgcctc cgtgacgttc tccaggacca cggcgagtgc
    19201 ctggcccact ccgatacaga tcgcggcgag gccccatcgc ccgccggact ccttcagccg
    19261 gtgggccagc gtgccgagca gccggccgcc ggaggcgccc agggggtggc cgagggcgat
    19321 ggcgccgccc ttggcgttga ccgtcgcggg atcgatcccc caggcgtcca cgcaggccag
    19381 cgcctgtacg gcgaacgcct cgttgagctc gaccgcggag acgtcggacc aggagatgcc
    19441 cgcaccgcgc agcgcccggt tcgccgcctc caccggggcg aagccgaaca gctgcgggtc
    19501 cagcgcgaag accccgcgcc ccgcgatccg cgccagcgga tcggcaccga tgcgggcggc
    19561 ggccgaccgc gagccgagca gcaccgccga ggccccgtcg ctcagcggcg aggcgttgcc
    19621 cgcggtgatc acgccgtcgg ggcggaaggc gggcttcagc gcggcgagcc cgtcggccgt
    19681 ggagccgggc cggatgccct cgtcccggcc gagggtgccg cccttgccgt ccaccggaac
    19741 cggcaccacc aggtcctcgt agaagccggc gttccaggcc gcgtcggcga gttcgtggga
    19801 ccgcgcggcg aactcgtcct gccgccggcg ggggatgggg aaccgttcgg ccagctgctc
    19861 gttggcctcg cccagggaga ccgtccactc cttcggcatg cgctcgttga ccagccgcca
    19921 gcccagggtg gtggacaccg cggtcatgtc cccggcggga taggcgcggt gcggtttggg
    19981 cagcacccac ggagcccgcg acatcgactc caccccgccc gtcagtacga cgtcggcgtc
    20041 cccggtctcg atggcccggg aggcgatgat cgccgcgtcc aaagaggagc cgcacagccg
    20101 gttgacggtg gtggcgggaa cgctggtggg cagtccggcc agcaggacgg ccatcctgcc
    20161 gacgttgcgg ttgtcctcac cggcgccgtt ggcgttcccc cagacgacgt cgtcgaggcc
    20221 gtccgccgcg aactccggca ccttggccag gaccccgttg acggcgagcg ccgccaggtc
    20281 gtcgggccgg acgccggcga gggcgcccga gaagcgtccg aagggtgttc ttgccgctgc
    20341 gtagagataa ctgtcggtca cgccgccacg gtaggagcgc gcgcttgttc acgtccaaga
    20401 cctaatggcg agtgattgag aagcactgct tatcaaggcc gtacagtgac cccatggagc
    20461 tccggcaggt ccgctacttc ctcgctctcg ccgaggagtg ccacttcggc cgtgcggcgg
    20521 cccgcctgca cgtcgcccag cccgcgctct cccagcagat caagcagctg gagcgcgagc
    20581 tgggcaccgc cctgttccac cgctccaccc gccatgtcga cctcaccgag gcggggcggg
    20641 acctggtcgg gtacgcccgc gccctgctcg ccgaggagca gcgcgcgcgg gcccacatgg
    20701 cggagctggc cggcggcggc gcgggacggg tctccgtcgg tttcatcggc accgccacct
    20761 acgacgtgct gccgcgcgtc tcccgcacgg tgcgggcccg gttgccgggc atctcgctgg
    20821 agctgcacgg cgaggtgctc accccgcagc tcctcgacgg cctgctcacc ggcgcgtacg
    20881 acctcgcggt gtgccgcccc gacacggccg ggatcgcgca ggtccgcacg gcgccgctgc
    20941 tcaccgagtc cctgatggcc gtactgcccg cacgccaccc gctggccgcc cgcccggtcc
    21001 tgccgctgcg tgacctggcc gacgaaccct tcgtcatcca ctcctcgcag ccccggtcct
    21061 ccatgtacga ccgggtcctg tccgcctgcg accgggccgg gttccggccc tcgtccctcg
    21121 tcgaggtcgg cgagacggcc accctggtcg tcttcgtcgc cgcggggcac ggcgtggcgc
    21181 tcgttccgca gtccgtccgg agcctgcggc tggacggcgt gacgtacgtg ccgctcgccg
    21241 agccggaacc ggtggacctc gtcctggccc gccggacccg ccccgactca ccggcggtcg
    21301 agcgggtcgc ctcggtgatc gagcagtgcg tacggggctg acggcgggga ccggaactcc
    21361 ctcaggcggt caccgccggc gcgttgtgcc gcgggcgtgc cggtgcccag cagcggatga
    21421 tgtcgcgcac cgagacgatg ccggcgggct cgcccccgtc gaggacgatg aggtgccgga
    21481 agccgccgtg cgtcatcgcc ccggccgcct cctccaccgt ccaggtcggc gcggcgaaca
    21541 cgacgtcggt ggtggtgtgg gcgtgcgcgt gctcggtgtc cgggttctgg ccccggccga
    21601 cggagaccag gacgtcgcgt tcggtgagga tgccgatgcc gccggcgtcc gggtcgtgca
    21661 ccacggccgc gcccacgtgg cgggccgaca tcagggcggc ggcctggcgc agtgtgtggg
    21721 cggggccgat ggtcaggacg accgtgctca tgacttcgtg gacgagcatg gggtgaagcc
    21781 acctcctgcc ggtgatccat gagtgtgttc atggattcac aagttcacaa gtgggggaac
    21841 cctcagagtg tcaggcagag cgcgggtcaa caagggggcg cggaagtgaa gtcggggcgt
    21901 gaagggcgtg cgcggcgctc cgtggcgccg gaccggtgtg ttcggccggg ctagtagcgc
    21961 tggttgaggt agccgagcag ctcgtcgtgg agcctgccgt tcgaggccgc cgcgttgccg
    22021 ctgtgcgggc cggggcggcc gtcgaggccg gtgaaggtgc cgcccgcctc cgtgacgatg
    22081 accgaggcgg ccgccatgtc ccagagcgcc agctcgggtt cggcgcagat gtcgaccgag
    22141 ccctcggcca ccatcatgta cggccagaag tcgccgtacg cgcgggtgcg ccacacctcg
    22201 cgggtcaggt cgaggaagcc gtcgagccgg ccctgctcct cccagccgcc gagcgaggag
    22261 tacgcgaacg aggcgtcctt gagcgtggag acctgggaga cgtggagccg ggaggccgag
    22321 gtcaggctgc ggccggtgaa cgcgccgtgg tccagcaccc cccaccagcg gcggccgagc
    22381 gcgggtgcgg agaccaggcc gacgaccggc tggtagccgc cctctcccgc ctccatgagg
    22441 gcgatgagcg tggcccagac ggggacgccg cgcacgtagt tcttggtgcc gtcgatcggg
    22501 tcgatcaccc agcggcgggg gccggcgccc gccacgccga actcctcgcc ctggaccgag
    22561 tcgcgggggc gggcgcgggc gaggtggcca cggatgagtt cctcggcggc cttgtccgcc
    22621 tcgctcaccg gggtcatgtc cggcttcgtc tcgaccttga ggtcgagggc cttgaagcgg
    22681 tccatcgtcg cggcgtcggc ggcgtcggcg agaacgtggg cgaggcggag gtcgtcgagg
    22741 tagtcgggca tgcgggtcac ggtatctgtc gggggtggta cggggccacc aggggtttgg
    22801 cgggcgtggc gggccgcggg ccgcgtgcgc ggtgcgggtg cgttcagttc gtatccgggg
    22861 ttggtgcggg gcgggggtgg gtcgcgcagc ccggcgctga cggggtgccg ctgcgcccac
    22921 ccgtgccgcc ccagcggcgc gactgcccgc agctggggcg gcaggactgc ccgcaggggc
    22981 gcggtggtga tgtgcgcgcg ggctcttgac agtgttgtcg ggcgcgtcaa atctgggcag
    23041 cgagtcggtc ggccgaggga ggcgagggtg cctgcagccc gggagtccct gctcgacgcc
    23101 gcttacacgg cgctggcgcg ccggccgtgg gccgccgtgc ggatggtgga cgtggccgcg
    23161 tcggccgggg tgtcccggca gacgctctac aacgagttcg gcagcaagga cggtctcgcg
    23221 cgggcgctcg tcagacgcga ggccgacggc tacctcgccg gcgtggagcg cgcgctctcg
    23281 ggccccagcg acccgcgtga acggctcacc gcgaccgccg aatggatgat gtccgccgcc
    23341 cacgacaacg tgctcgtccg cgccctgctc accggctgct ggaacgagcg gctgcccgca
    23401 ccggccctgt cggccgtgcc ctcctcctcc ggcgtcccgg cccagcgccg ggccgacggt
    23461 ccgctgccct cgcccggcga cttcgtgacc ctcgtccgcg accgcgccgt ggccgtcctg
    23521 aacggcgggg gcccgctcgc gccgccggcc gccggcgagt tggcccgctc ctgcgaactc
    23581 gccgtgcggc tcgccctgtc ctgcgtcgcc gcgccgcccg ccgagggcgg ggtcgccgac
    23641 ctcgtacgca ccgccctgcc ccgccggctg acggcgtagc ggctagtggg cggagcccga
    23701 gagctggagg ccgatcacgc cgatgatgac caggctgatc gagacgagct tgagaaccga
    23761 gaccaggtcg ccgaggaaga tcatgccgta gatggcggtg cccgccgcgc cgatgcccgt
    23821 ccacacggcg tacgccggac cgacgtcgag cttcttcagg gacatcgtca gcagaccgaa
    23881 gctgcccagc gcgaaggcgc agaaggcgat cgtgggccag agccgggtga agccgtgcga
    23941 cagcttcaga cagacggcga agccggtttc gagcaccccg gccactatga ccagcagcca
    24001 cgccattgct tgtcctcccg tagttcccgt accgcgaccg ctgcgtcgtc gccgatccgg
    24061 cgactcgtcc ggctttgctc gggcttggtt ccggcttggt gcgattatgc acttaccggt
    24121 ggcacgccac ggcaaacaac gcggaggtca gtcgccctcc ctgcgttccc gcgtcgacag
    24181 cagccggcgc agcgagtaca gccgtgccgg gtcggcgtgc ccctcctcga cccaggcgtc
    24241 cagcgcgcag tcgggctcgt cgtgactgca cgcgcgcggg cagccctccg tgccgggcac
    24301 caggtccggg aaggcgttga tcacccggga cgggtcgatg tgcgcgaggc cgaacgaccg
    24361 tacgcccggg gtgtcgacga cccagccgcc cccctcggag gagagcggca gcgcgagggc
    24421 ggaggtcgtg gtgtgccggc cgcggcccgt caccgcgttg acgtgtcccg tcacccggcg
    24481 gcggtcctcc ggtaccaggg tgttgaccag ggtcgtcttg ccgacacctg agtggcccac
    24541 gaaagccgtg atcttgccgt ccaggtgctc gcgcacgagt tcggccgcgg cgccgttctc
    24601 cagcccctcg cggctggtga ccacgtacgg gatgtccagc gcgccgtaga gctccaggag
    24661 ttcgtccggc ggggccaggt ccgacttggt catcaccagc agcggggtga ggcccccgtc
    24721 gaaggccgcg accaggcagc ggtcgatgag gcgcgggcgc ggctcggggt cggcgagggc
    24781 ggtgacgacg gcgagctggt cggcgttggc gacgaccacc cgctcgtagg ggtcgtcgtc
    24841 gtccgccgtg cggcgcagca cggaggtgcg ctcctcgatg cgcacgatgc gggcgagggt
    24901 gtccttcttg cccgagaggt cgccgaccag ggccacccgg tcgcccacga ccgcggcctt
    24961 gcggcccagt tcgcgggcct tcatcgccat gacgacccgg tcctcgacca ggcaggtcag
    25021 ccggccccgg tccaccgtga ggaccaggcc gccggcggcg tcctcgtgct tgggccggat
    25081 atgggtccgc ggccggttgc ccttgcggtg gggccgggtg cggatgtcgt cctcgtcggt
    25141 gtgcttgccg tagcgccgca tggcgaaccg tccctacgcc ccgagcatcc cggtccacag
    25201 gtcggggaag tcgggcaggg tcttcgcggt cgtcgccacg ttctcgatcc gtacgtcctc
    25261 gacggcgagg ccgaggaccg cgccggcggt ggccatgcgg tggtcgtcgt aggtgtggaa
    25321 gatgccttcg tgcagggggc gcgggcggat gtgcagaccg tcggcggtct cggtgacgtc
    25381 gccgccgagt tcgttgatct ccttggtgag cgcggccagg cggtccgtct cgtgcaggcg
    25441 caggtgcgcc accccgcgca gggtggaggg ggagtccgcg agggcggcga cggccgcgat
    25501 gcccggggtc agctcgccga cctcgccgag gtcgacgtcg atgccgtgga tcgcgccc
//
