LOCUS       NZ_CP063142            23546 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Priestia filamentosa strain GN1 chromosome.
ACCESSION   NZ_CP063142
VERSION     NZ_CP063142.1
KEYWORDS    RefSeq.
SOURCE      Priestia filamentosa
  ORGANISM  Priestia filamentosa
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Priestia.
REFERENCE   1  (bases 1 to 5133640)
  AUTHORS   Buch,A., Patel,D. and Chandnani,M.
  TITLE     HCA producing B. filamentosus GN1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5133640)
  AUTHORS   Buch,A., Patel,D. and Chandnani,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAY-2020) Department of Biological Sciences, P D Patel
            Institute of Applied Sciences, Charotar University of Science and
            Technology, Changa, Anand, Gujarat 388421, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. v-3.13.0
            Assembly Name                     :: CHAR_BFil_1.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina Nextseq500
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022811745.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 08:14:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,159
            CDSs (total)                      :: 5,093
            Genes (coding)                    :: 5,023
            CDSs (with protein)               :: 5,023
            Genes (RNA)                       :: 66
            rRNAs                             :: 2, 1 (5S, 16S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 70
            CDSs (without protein)            :: 70
            Pseudo Genes (ambiguous residues) :: 0 of 70
            Pseudo Genes (frameshifted)       :: 21 of 70
            Pseudo Genes (incomplete)         :: 52 of 70
            Pseudo Genes (internal stop)      :: 15 of 70
            Pseudo Genes (multiple problems)  :: 15 of 70
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:46:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4988824
            Orig. end                         :: 5012370
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP063142.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr Aditi Buch, Department of
            Biological Sciences, P D Patel Institute of Applied Sciences,
            CHARUSAT.
FEATURES             Location/Qualifiers
     region          1..23546
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="15"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23546
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23546
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13546](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13546)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    284..299
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.25"
                     /tool="antismash"
     gene            complement(515..1285)
                     /locus_tag="HPB58_RS24920"
                     /old_locus_tag="HPB58_24850"
     CDS             complement(515..1285)
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (10-129). E-value: 1.2e-11.
                     Score: 36.7. Matches aSDomain:
                     nrpspksdomains_HPB58_RS24920_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010331469.1"
                     /locus_tag="HPB58_RS24920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24850"
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_243515877.1"
                     /sec_met_domain="adh_short (E-value: 1.2e-33, bitscore:
                     114.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 6.4e-34, bitscore:
                     116.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKANFDLTGKVAFVTGAGRGIGRTIAEGLASAGADVILLARTEGE
                     VGEAAADIAEKTGRKTLPIVCDVTNSSSIQEAVDFALQQFHKIDILINNAGTSVRKTSF
                     ELLEEEWDTVIDVNFKSVFLLSKVIGKHMVEQKWGRIINIASVASSLTLSSGTPYGPSK
                     AGVVQLTRQLANEWAKEGITVNAISPWFFKTSLNEEALDNKDFRTMIENRTPMKRLGNL
                     EELITPVIMFCADGAGYITGQNLFVDGGVTHYGF"
     aSDomain        complement(899..1255)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HPB58_RS24920_PKS_KR.1"
                     /evalue="1.20E-11"
                     /label="HPB58_RS24920_PKS_KR.1"
                     /locus_tag="HPB58_RS24920"
                     /protein_end="129"
                     /protein_start="10"
                     /score="36.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAFVTGAGRGIGRTIAEGLASAGADVILLARTEGEVGEAAADIAE
                     KTGRKTLPIVCDVTNSSSIQEAVDFALQQFHKIDILINNAGTSVRKTSFELLEEEWDTV
                     IDVNFKSVFLLSKVI"
     CDS_motif       complement(1163..1246)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HPB58_RS24920_0001"
                     /evalue="6.50E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="HPB58_RS24920"
                     /protein_end="41"
                     /protein_start="13"
                     /score="15.6"
                     /tool="antismash"
                     /translation="VTGAGRGIGRTIAEGLASAGADVILLAR"
     gene            complement(1499..2482)
                     /locus_tag="HPB58_RS24925"
                     /old_locus_tag="HPB58_24855"
     CDS             complement(1499..2482)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019394025.1"
                     /locus_tag="HPB58_RS24925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24855"
                     /product="carbohydrate kinase"
                     /protein_id="WP_243515880.1"
                     /transl_table=11
                     /translation="MQKTIKKNSSVVCIGELLIDFFCTDIDVDLTRGKQFLKNAGGAPA
                     NVSAAIAKLGGDALFSGKVGADSFGYFLKQTLENLNVDTSMLVMDKEAITTLAFVSLTN
                     DGERDFMFHRGADALLTIDDINQDKIDSAKILHFGSATALLENPFQETYLTLMKKANED
                     RIFTSFDPNYRIDLWKGRIGEFVDLAKVAISSSDFVKVSEEELHLITDTTDDLAGIDFL
                     HGLGAKIVAVTLGKRGTLLSNGKRAELVKSLPVVAIDSTGAGDAFVGATLYKLAGKENL
                     EDIYTNFEQLYEIISFANKVGAHVCTKIGAIAALPSIEELHELSIS"
     gene            complement(2538..3938)
                     /locus_tag="HPB58_RS24930"
                     /old_locus_tag="HPB58_24860"
     CDS             complement(2538..3938)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015486 -
                     glycoside-pentoside-hexuronide:cation symporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003328516.1"
                     /locus_tag="HPB58_RS24930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24860"
                     /product="glycoside-pentoside-hexuronide (GPH):cation
                     symporter"
                     /protein_id="WP_243515882.1"
                     /transl_table=11
                     /translation="MIERERTVIQENSNKRLSYSNSRLSWLERFGYGLGDMSYNIIFQF
                     VNAYLLFYYTDIGGISPGIIATLFIVVRVLDAIFDPIMGVILDKTNTRWGKARPYLLWV
                     SIPFGLFTVLCFTTPDFGANGNIAYAYITYILLGMTFSMQTIPVNSLTGRITNNIQERT
                     LLTTTRMILVYIGILLSISCATPLATALGGENQAVGFQLTAIIYAAVSIVLNLMSFFTV
                     RERVKPKKSKKYGIKKTLSVLFKNKPLLILASSFLAFAIGFNIKLSTMVYYFTYNVDRK
                     DLVFMGTLLFFGAALISNLFIPYFSNRWGRKNVMIVTAALSLFTYAGLQFTSYSSLTFI
                     FILLFASGFFTTPLNTLAWGMVADCVDYAEWKTGVRADGVVISSMSFTNKLGVALAGSF
                     AALYLGKNGYVANTEQTLHSLDAIKNMNALVPGVFILLSIIIICFYPLNEKKYKKMMEE
                     LNQKPSHK"
     gene            complement(4027..5088)
                     /locus_tag="HPB58_RS24935"
                     /old_locus_tag="HPB58_24865"
     CDS             complement(4027..5088)
                     /NRPS_PKS="Domain: PKS_ER (18-269). E-value: 4.5e-15.
                     Score: 47.5. Matches aSDomain:
                     nrpspksdomains_HPB58_RS24935_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388496.1"
                     /locus_tag="HPB58_RS24935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24865"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_243515884.1"
                     /sec_met_domain="ADH_N (E-value: 1.5e-34, bitscore: 116.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 8.5e-33, bitscore:
                     111.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNNVPTTMKAAVMHSIRDIRIETLPVPQLKDDEVLVKVMAVGIC
                     GSDLHYYTDGRIGHYKVEKPIILGHECAGEVAAIGANVNRVKVGDRVAAEPGVTCGACE
                     ACKEGRYNLCPDVEFLATPPVDGAFVQYIKMRQDFVFQIPDTLSYEEAALIEPFSVGIH
                     AATRTKLQAGEIVAIMGMGPVGLMAVAAAKAVGASKIIVTDLEPLRLEAAKQMGATHTI
                     NIAEQDPAGEISKITSGKGVDVAWETAGNPAALQSALSSLRRGGRLAIVGLPAQNEIPL
                     NIPFIADNEVDIYGIFRYANTYPKGINFLSSGIVDAEKLVTDRYGLEDTMEAMERALNH
                     KNECLKIVVYPNQ"
     aSDomain        complement(4282..5034)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HPB58_RS24935_PKS_ER.1"
                     /evalue="4.50E-15"
                     /label="HPB58_RS24935_PKS_ER.1"
                     /locus_tag="HPB58_RS24935"
                     /protein_end="269"
                     /protein_start="18"
                     /score="47.5"
                     /tool="antismash"
                     /translation="DIRIETLPVPQLKDDEVLVKVMAVGICGSDLHYYTDGRIGHYKVE
                     KPIILGHECAGEVAAIGANVNRVKVGDRVAAEPGVTCGACEACKEGRYNLCPDVEFLAT
                     PPVDGAFVQYIKMRQDFVFQIPDTLSYEEAALIEPFSVGIHAATRTKLQAGEIVAIMGM
                     GPVGLMAVAAAKAVGASKIIVTDLEPLRLEAAKQMGATHTINIAEQDPAGEISKITSGK
                     GVDVAWETAGNPAALQSALSSLRRGGRLA"
     misc_feature    5267..5285
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 26.8"
                     /tool="antismash"
     gene            5330..7870
                     /locus_tag="HPB58_RS24940"
                     /old_locus_tag="HPB58_24870"
     CDS             5330..7870
                     /GO_function="GO:0043531 - ADP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019394028.1"
                     /locus_tag="HPB58_RS24940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24870"
                     /product="NB-ARC domain-containing protein"
                     /protein_id="WP_243515886.1"
                     /transl_table=11
                     /translation="MAELERHEEFAALLSKGVKSLKHHPNYKIKRNRSESASLGQSYLD
                     KIAYQIGVSSNTLKSWMGQMGLKYIPGRIDDGKLFGILWTIIKEEYMNKEWFTNVLATT
                     SIPTITPPIPVWITSCFRKAKILRNDSSFGPPNEEEINEVISKLFDSPPSHPNPEIKEE
                     PLMHNLPTRGSGQFIGRHHELEVIRQWIHSPSPVCLIAGWAGMGKTTIALEAAYLCIEQ
                     LNRNQEWPVFKRIIWINGDWKGLSFNDFLDTIAYQLGRAEQIDKSIAEKRLVVRNVLAI
                     YSQQQPLLLIVDSIDKAESEIYEFVMGLPQGVKVILTARENLNQKYKAGFLEINTIQLK
                     GFEEGEAGDFFSYEISRHLQTYLSSSKKTKIEQLSNIPLNVQKELILATAGNPKALSLS
                     IAYILDNNIPVEQLIQKIRNAGYSLVELFDFLFGSTWDKCNEDTQRLWQVLCFFHSPPD
                     EKSWATAAGLDSRKFYYAVEKLRTHALVQQNYIGDKPHYLAHQTVVTYGKQHLDADEDF
                     EKNSRKRWSQYYIQYLDTHLKREQPQFIYWSYLLGRDLEKIKQEWPNILKALEWASKHA
                     EKELVMNLILRLSHFLSRVNLPLRIQYGIEAANYAHQMNDKISEALIRIDIIGWALMEV
                     NKLEEAYSQIEEGLLILKATDEIHQEGHDLKIWGLALKSKLFLKTERIEEAKNILKKIC
                     NVPVAPVIKHRVLLMQGDFCLLTKNYKEAIHFYELANEKSMLYGGEKTIEAYFNLGLAY
                     MHCDFYEKAEKMFNNLLYNQNKPNQIELIYCYYGKAQILARKRKYKEAYDLNEKVINLI
                     HSWEPTINIRQEVEKFHKSMNENLLKNTHIRDGI"
     gene            complement(7902..8951)
                     /locus_tag="HPB58_RS24945"
                     /old_locus_tag="HPB58_24875"
     CDS             complement(7902..8951)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019394029.1"
                     /locus_tag="HPB58_RS24945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24875"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_243515888.1"
                     /transl_table=11
                     /translation="MEIGISTFVETTPDVRTGEVISHAQRIREVVEEIVLADQVGLDVF
                     GVGEHHREDYAASSPAVVLAAAASQTKNIRLTSAVTVLSSADPVRVFQDFATLDGISNG
                     RAEIMAGRGSFIESFPLFGYDLRDYEELFDEKLDLLLKLQTSEKITWSGKHRPAIENLG
                     VYPRPVQKPLPIWIGSGGNQESVIRAGLLGLPLVLAIIGGSPLHFAPLVELYKKAAEHA
                     GHDSSKLKVASHSHGFIADDTETAADKFFPPTQYAMNKLGKERGWGPYNRSSFDAARSF
                     EGALYVGDADTVAEKIIHLRKNVGIERFMLHVPVGTMPHEDVMRAIELLGTRVAPKVKE
                     EVARWESVQ"
     gene            complement(8982..9329)
                     /locus_tag="HPB58_RS24950"
                     /old_locus_tag="HPB58_24880"
     CDS             complement(8982..9329)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HPB58_RS24950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HPB58_24880"
                     /product="hypothetical protein"
                     /protein_id="WP_243515891.1"
                     /transl_table=11
                     /translation="MSKIIEDEHYYNNCYKVIDDILEFERVYMVDEYQFNKETYEMLGK
                     VYKSLPCYLRDHVDSPHWYGCEEKGDPYFISVSFEMSGLQFWGKVPITQFSQWEKALHK
                     GIEDFPFKYQV"
     gene            complement(10001..11578)
                     /locus_tag="HPB58_RS24955"
                     /old_locus_tag="HPB58_24885"
     CDS             complement(10001..11578)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003252868.1"
                     /locus_tag="HPB58_RS24955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24885"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_243515893.1"
                     /sec_met_domain="PF00881 (E-value: 2.5e-07, bitscore: 29.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLEEFLYNLHFDIDKANQPNWEADWEDAPLAYKLYRGLPVVPLS
                     TEVPLTLTGGEPPARLDLNRVGHFLWYVFGFTQLSQSAFPMDSTEQDSYPLQSYRRFAP
                     SGGALYPNELYVYLKVEGLPDGVYHYDVAHHSLVLLREGNFDSYLARALGNRCDISSCF
                     GIVFVSTMFWKNFFKYNNFAYRLQGLDAGVLLGQLMEVAKRFGFASGVYFQFLDTAINH
                     LLGLSEQEESIYSVIPLSVEATIWSPTGRNLYENIISEELRKELPAIQPEHFERSLSVK
                     EYPMITAMNAASKLDSTRSFRVMGGRGTAERVDPAVALPHIEPLSYDLAEACRNRFSPD
                     MDFVLGMVSQQQLATLFREATASFSYRNDLDEAYRSNVPRVTIYSCLYNVEGISNGAYY
                     YDSTKHMLREICPGDHRLHLQTGMSLDNVNLLEIPLCLHVAGDKEFYKAELGYRGYRIQ
                     QMEAGMLVQRLLLAAQALGMGGHPLLGFDANLSDELYKMDQQGKTSLIQIPIGPYRPRP
                     WLRGSLHS"
     gene            complement(11600..13546)
                     /locus_tag="HPB58_RS24960"
                     /old_locus_tag="HPB58_24890"
     CDS             complement(11600..13546)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03882"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013877478.1"
                     /locus_tag="HPB58_RS24960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24890"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_243515895.1"
                     /sec_met_domain="TIGR03882 (E-value: 1.5e-44, bitscore:
                     150.3, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 5.1e-76, bitscore: 254.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 3.2e-126, bitscore:
                     419.4, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSFVLVVGEGVLADLVSEELSAHHLVIRKPNFEEGVPKNTDLAL
                     FLDDDWEPSVHQKAEEVLRKTGTPWLRGFVSFGEGVVGPLVRPGAAGCSQCADMRRLMG
                     GRDRTEMQQVQQRLAVTGGIGSDPWASSTGLLQMAYLIGVEVQNLLQGNQAYSEGKIYL
                     IDLKTLNSSWHSFLPNPLCSVCGRLPDDSQTLARISLQPSPKLSSSIFRCRQLDEMKKV
                     IVKDYLDNRTGLLNSKMYDLVTPFADASVNLPMFDGDEGTAGRTHSYAESVLTAILEGL
                     ERHCGLEPRGKRTVIHDSFHNLENQALNPLKVGVHAKEQYAQPSFPFKSFDPDRSINWV
                     WGYSLLEGRPILVPELLAYYSVGCASQGFIYETSNGCALGGSLEEAIFYGIMEVVERDS
                     FLMTWYAKLNLPRLDPFTAGDQELELMVERMRAVAGYDLYLYNSTMEHGIPSIWAIAKN
                     RKEKGLNLICAAGAHLDPVRAVKSAVQELAGMMLNLDEKFEANQEEYERMLHDSSLVRQ
                     MEDHGMLYGLPQAEERLSFLLDDNSPMRSFKEEFRWKSNHTDLTDDLQDILQVFRQLNL
                     DVVIIDQTTPETIRNGLYCVKVLIPGMLPMTFGHHLTRLTGLERVFRVPMELGYTNKPL
                     TPEQFNPHPHPFP"
     gene            complement(13543..15498)
                     /locus_tag="HPB58_RS24965"
                     /old_locus_tag="HPB58_24895"
     CDS             complement(13543..15498)
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019394033.1"
                     /locus_tag="HPB58_RS24965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24895"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_243515897.1"
                     /sec_met_domain="TIGR03693 (E-value: 4.3e-234, bitscore:
                     776.6, seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     5.1e-50, bitscore: 165.6, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 4.5e-14,
                     bitscore: 50.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNLNPSMRLKVKRDTFYLPEPNRGVYFRNNLSSFRIEGSGIDQW
                     IEKLLPMFNGEYTLGNLTNGLPGPYRERVYEIAEVLYTNGYVRDLSQDLPHQLSGYQLK
                     KHASQIEFVDNLVGSGAARFQDFRQNKVLAVGSGPILNSLVSSLIESGLTKVRVLITDE
                     VPTNRQRLKELVEHARKIDSEVDLKEIPQKKEGWREIVKPFDSILYVSQEGELEELRHL
                     HIVCREEKKMFLPAICLQQVGLAGPLVHPDSEVCWETAWRRLHHSALFKNGQFPAFSAT
                     PGSLLANVIVFELFKEVTGVMELEQKNRVFLLNLDTLEGNWHSFLPHPLVTSSISAEWV
                     EDVGSRLQVGLEKVESGKLLLYFNQLTSEESGIFHIWEEGDLKQLPLAQCRVQAVDPLS
                     EGPAELMQDIVCSGLTHEEARREAGLTGIETYVSRMVSLIVNTLPLNKNVDGSVVVPED
                     IVGVGAGESFVEGVGRGLQKCLAEELSKQQLNQKYSVSRVQLSVIEDERCRFYLEALTT
                     MQGAPIIGRGKELFGFPVVWVGTKDGWYGSADLNITMALRKALQQALIKVQNKPDSSNE
                     LACEVTSVLLEEKMPISLSIPACDERIQADILKEAMEILEHKGKRVLVFELGIEPVFKE
                     QLDGVFGVLLREEESH"
     aSDomain        complement(15202..15498)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HPB58_RS24965_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="2.80E-52"
                     /identifier="RREFam011.1"
                     /label="HPB58_RS24965"
                     /locus_tag="HPB58_RS24965"
                     /protein_end="99"
                     /protein_start="0"
                     /score="165.6"
                     /tool="antismash"
                     /translation="MTNLNPSMRLKVKRDTFYLPEPNRGVYFRNNLSSFRIEGSGIDQW
                     IEKLLPMFNGEYTLGNLTNGLPGPYRERVYEIAEVLYTNGYVRDLSQDLPHQLS"
     aSDomain        complement(15232..15477)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HPB58_RS24965_Thiopeptide_F_RRE.1"
                     /evalue="2.50E-16"
                     /identifier="RREFam004.1"
                     /label="HPB58_RS24965"
                     /locus_tag="HPB58_RS24965"
                     /protein_end="89"
                     /protein_start="7"
                     /score="50.4"
                     /tool="antismash"
                     /translation="MRLKVKRDTFYLPEPNRGVYFRNNLSSFRIEGSGIDQWIEKLLPM
                     FNGEYTLGNLTNGLPGPYRERVYEIAEVLYTNGYVRD"
     misc_feature    complement(15625..15639)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            complement(15657..15938)
                     /locus_tag="HPB58_RS24970"
                     /old_locus_tag="HPB58_24900"
     CDS             complement(15657..15938)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03601.1"
                     /locus_tag="HPB58_RS24970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24900"
                     /product="heterocycloanthracin/sonorensin family
                     bacteriocin"
                     /protein_id="WP_243515899.1"
                     /transl_table=11
                     /translation="MNDFQNELQMLNVGDFQATQAVTWDQNQYYTDQDRQIVGVGFGFG
                     RCFRCFSCFNCFNCFNCFNCFNCFNCSRCSRCGGGGRCGGGGRCGGGS"
     gene            complement(16864..17256)
                     /gene="rpsI"
                     /locus_tag="HPB58_RS24975"
                     /old_locus_tag="HPB58_24910"
     CDS             complement(16864..17256)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002009728.1"
                     /locus_tag="HPB58_RS24975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24910"
                     /product="30S ribosomal protein S9"
                     /protein_id="WP_019394038.1"
                     /transl_table=11
                     /translation="MAQVQYYGTGRRKSSVARVRLVPGNGNIVVNGREIENYLSSAALR
                     EVVKQPLAATETLGNYDVLVNVNGGGFTGQAGAIRHGIARALLQADPEYRATLKPEGLL
                     TRDARMKERKKYGLKGARRAPQFSKR"
     gene            complement(17277..17714)
                     /gene="rplM"
                     /locus_tag="HPB58_RS24980"
                     /old_locus_tag="HPB58_24915"
     CDS             complement(17277..17714)
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388030.2"
                     /locus_tag="HPB58_RS24980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24915"
                     /product="50S ribosomal protein L13"
                     /protein_id="WP_019394039.1"
                     /transl_table=11
                     /translation="MRTTYMAKASEVERKWLVIDAEGKTLGRLASEVASILRGKHKPTY
                     TPHVDTGDHVIILNAAKIELTGKKLTDKIYYRHSQHPGGLKSRTALEMRTNYSEKMLEL
                     AIRGMLPKGSLGRQMFKKLHVFAGDTHPHEAQKPEVYELRG"
     gene            complement(17858..18601)
                     /gene="truA"
                     /locus_tag="HPB58_RS24985"
                     /old_locus_tag="HPB58_24920"
     CDS             complement(17858..18601)
                     /EC_number="5.4.99.12"
                     /GO_function="GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="truA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000439681.1"
                     /locus_tag="HPB58_RS24985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24920"
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="WP_243515901.1"
                     /transl_table=11
                     /translation="MRRIQCTVAYDGTLFSGYQIQPNARTVQEEIEKALTRLHGGKEVK
                     IHASGRTDASVHAKGQVFHFDTISTISVSQLERGANALLPEDIVVVDTKETSEDFHARF
                     SVKKKEYRYKVLCSKSRDVFLRHYMHHVPYELDRKVMKEAIKSVIGTHDFTSFCSAKTE
                     IEDKVRTIYEAEIIEEGDVLTFRFVGNGFLYNMVRILVGTLLDLGSGKSFTKDISGMLE
                     AKNRTLTGKTAPGHGLYLWKVYYDN"
     gene            complement(18614..19411)
                     /locus_tag="HPB58_RS24990"
                     /old_locus_tag="HPB58_24925"
     CDS             complement(18614..19411)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019394041.1"
                     /locus_tag="HPB58_RS24990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24925"
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="WP_243515903.1"
                     /transl_table=11
                     /translation="MMNNMIIGQYVPGDSFIHRMDPRAKLIIVFFYVAVIFLANNIVSY
                     SIIGLFAILAVLVSRVPIYFIIKGLKPILFIIIFTFLLHIFMTREGEVIADIGFLKIYE
                     GGVIQGIYISLRFLFLILLTTLLTLTTTPIEVTDGMETLLHPLKKVRFPVHELALMMSI
                     SLRFIPTLMDETDKILKAQTARGVDFSSGPLKDRLKAVVPLLIPLFISAFKRAEELATA
                     MEARGYQGGEGRTKYRQLSWGAIDTMALIIFVIVAAALFIVRV"
     gene            complement(19401..20273)
                     /locus_tag="HPB58_RS24995"
                     /old_locus_tag="HPB58_24930"
     CDS             complement(19401..20273)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019394042.1"
                     /locus_tag="HPB58_RS24995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24930"
                     /product="energy-coupling factor ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_243515911.1"
                     /transl_table=11
                     /translation="MEIIFKNVEHRYQLKTPFERLALEDVSLSIPSGQFVSLIGHTGSG
                     KSTVIQHLNALLKPTKGSIQIGDRTIESGKKEKHLKEIRKRVGVVFQFPEHQLFDETVE
                     KDICFGPMNFGVSEEEAKKRANELATIVGLPKEVLQKSPFDLSGGQMRRVAIAGILAME
                     PQVLVLDEPTAGLDPRGRNEIMNLISSLNKEQGLTIVLVTHSMEDAAQYADRIIVMDKG
                     KVSMSGTPKEIFKQYEKLKEIGLDIPEPLQFILDLEQRLGVSLSHGAITFQKAVEEVTK
                     LFGGQAHDE"
     gene            complement(20249..21088)
                     /locus_tag="HPB58_RS25000"
                     /old_locus_tag="HPB58_24935"
     CDS             complement(20249..21088)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019394043.1"
                     /locus_tag="HPB58_RS25000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24935"
                     /product="energy-coupling factor ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_243515913.1"
                     /transl_table=11
                     /translation="MSNSVIEVKDLYFRYEEDGPYVLNNLSLNVYKGEWLAIAGHNGSG
                     KSTLAKILNGLILPEQGSVKVADLMLTEDSVWDVRRHIGMVFQNPDNQFVGSTVEDDVA
                     FGLENNGFPYEEMRKRVGEAIEVVGMKGFEKYEPHRLSGGQKQRIGIAGVVAMAPDVIL
                     LDEATSMLDPKGRSEVLETIRLLKNQRNLTIISITHDLNEVAKADRAIVLNKGELFATG
                     TPSEIFELGSKLTEIGLDFPFASQISHVLRDKGISLEYIHLTTDNLVEELWRLYSKM"
     misc_feature    complement(21183..21199)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 21.87"
                     /tool="antismash"
     gene            complement(21263..21625)
                     /gene="rplQ"
                     /locus_tag="HPB58_RS25005"
                     /old_locus_tag="HPB58_24940"
     CDS             complement(21263..21625)
                     /GO_component="GO:0005762 - mitochondrial large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388025.1"
                     /locus_tag="HPB58_RS25005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24940"
                     /product="50S ribosomal protein L17"
                     /protein_id="WP_040056346.1"
                     /transl_table=11
                     /translation="MGYQKLGRTSAQRKALLRDLATDLIISERIETTEPKAKELKSVVE
                     KLITLGKRGDLHARRQAAAYIRHEVANEETGQDAVQKLFSDVATRYADRQGGYTRIMKL
                     GPRRGDGAPMAIIELV"
     gene            complement(21662..22606)
                     /locus_tag="HPB58_RS25010"
                     /old_locus_tag="HPB58_24945"
     CDS             complement(21662..22606)
                     /EC_number="2.7.7.6"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003899 - DNA-directed 5'-3' RNA
                     polymerase activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003178382.1"
                     /locus_tag="HPB58_RS25010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24945"
                     /product="DNA-directed RNA polymerase subunit alpha"
                     /protein_id="WP_019394045.1"
                     /transl_table=11
                     /translation="MIEIEKPKIETVEISDDGKFGKFVVEPLERGYGTTLGNSLRRILL
                     SSLPGAAVTSIQIDGVLHEFSTIPGVVEDVTNIILNVKKLALKIYSDEEKTLEIDVQGK
                     GVVTAADIQGDSDVEILNPDLHIATLETDAQFRMRLTAQTGRGYDAAVENKHEDQPIGV
                     IPIDSIYTPVTRVSYYVENTRVGQMTNFDKLTLDVWTDGSIEPEKAVALGAKILTEHLN
                     IFVGLTDEAQKAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQELANKT
                     EEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD"
     gene            complement(22781..23170)
                     /gene="rpsK"
                     /locus_tag="HPB58_RS25015"
                     /old_locus_tag="HPB58_24950"
     CDS             complement(22781..23170)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016998822.1"
                     /locus_tag="HPB58_RS25015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_24950"
                     /product="30S ribosomal protein S11"
                     /protein_id="WP_019394046.1"
                     /transl_table=11
                     /translation="MARKTNTRKRRVKKNIESGIAHIRSTFNNTIVTITDMQGNAISWS
                     SAGALGFRGSRKSTPFAAQMAAETAAKTGMENGLKTLEVTVKGPGAGREAAIRALQAAG
                     LEVTAIKDVTPVPHNGCRPPKRRRV"
     misc_feature    23280..23295
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.33"
                     /tool="antismash"
ORIGIN
        1 tagaaaatcc taatattatt gaatgccatc gattaactgg ttctgttaac tatttattga
       61 aagctgctgt ttcaagtatg aagcatttaa gtcagcttat agattccctg cttccatttg
      121 gtcatgctaa tacatctatt gtcctttcat cacccattcc ttttaaatgc attgttcctg
      181 atatagctca tcaagaataa gagttcttaa aagtatcgga aagaaaatct aaaaattctt
      241 ccatacttca aaaataatga gttgagggta tcttccctta acaattttca attgtaaaaa
      301 agcaaaatta agataggaac acttccatac ttaaagccca gttttagttc taaaatatca
      361 acagtaataa cttaaatcag aaaatgcacc aaatcataat gatttggtgc attttctcta
      421 caataattca gaattcctta tatcattata ttgtcatgca ttcttcattt aaaacgatta
      481 cggtaaataa ataactcttc ctacttagtt attatcaaaa gccgtaatgc gttactcccc
      541 catctacaaa taaattctgt cctgttatgt agcctgctcc atctgcacaa aacataataa
      601 caggtgtaat caattcttca agatttccta atctcttcat aggggtgcga ttttctatca
      661 ttgttctaaa atccttatta tctaaagctt cttcattcaa ggacgtttta aagaaccacg
      721 gacttattgc atttactgtt atcccttcct tagcccattc atttgctaac tgacgtgtta
      781 gttgaacaac tccagcttta cttggtccat atggagttcc agatgataat gttaaagaag
      841 aagcaacaga agctatatta ataatcctgc cccatttctg ttccaccata tgctttccaa
      901 taacttttga aagcaagaaa acagatttaa agttcacatc tattacagtg tcccattctt
      961 cttctaacag ctcgaagctc gtctttctca cacttgttcc agcattatta attaaaatat
     1021 cgattttatg aaattgctga agagcaaaat caacagcttc ttggatagag gaactgttcg
     1081 ttacatcgca cacaatcggt aaagtttttc ttcctgtctt ttcagcaata tcagcagcag
     1141 cctccccaac ttcaccttcc gttcttgcta aaaggataac atcagctcca gcacttgcta
     1201 atccttcagc tattgttctt cctattcctc ttccagcccc tgtaacaaat gcgactttac
     1261 ctgttaagtc aaaatttgct ttcaatgtgt gattccctcc aatattctgc gtttattatg
     1321 ttcctttatg agctccccta aagacctctt acataatatt taccctttaa atactttcat
     1381 gctaacgttt atactttcct tcttacctta ggcagttata aaaataaaga caaaagacta
     1441 agcaaagaaa tagtacattg cttagtcttt tatctttgta tatgtttgtc tatatcaact
     1501 aacttatact caactcatga agttcctcaa tacttggcaa ggctgctatt gctcctattt
     1561 ttgtacaaac atgagcaccc actttattgg cgaaagaaat aatttcatac agctgttcaa
     1621 aattcgtata aatatcttca aggttttctt tacctgctag tttatataat gttgctccaa
     1681 caaaggcatc tcccgctcct gtagaatcaa tagcaacgac tggaaggctt ttaacaagct
     1741 ctgctctctt cccattagat agaagcgtcc cccttttacc tagagtaacg gcaacaattt
     1801 tagcaccaag accatgaaga aaatcaatac ctgctagatc atctgtagtg tctgtaataa
     1861 ggtgtaattc ttcttcgctt actttaacaa agtcacttga agaaatagct acttttgcga
     1921 gatctacaaa ctcacctatt cttcctttcc acaaatcaat tcgataattt ggatcaaaag
     1981 aggtgaatat tctatcctca ttagcttttt tcataagtgt taaatatgtc tcttgaaaag
     2041 gattttctaa taatgctgtt gcagacccaa agtgtagaat cttggcacta tctattttat
     2101 cttgattaat atcatctatt gtgagcaacg catctgctcc tctatggaac atgaaatctc
     2161 gctctccatc gtttgttaaa gaaacaaatg ctagagttgt tattgcttcc ttgtccatca
     2221 caagcattga agtatctaca ttgagattct ctaatgtttg ttttaaaaag tagccaaaag
     2281 agtcagcccc tacctttcca ctaaataagg catctccacc tagcttagca atggcagcag
     2341 agacattagc aggtgcacca ccagcatttt ttaaaaactg ttttcctctt gttaaatcaa
     2401 catcaatatc tgtacaaaag aaatcaatta gtagctcccc aatacaaaca actgatgagt
     2461 ttttctttat ggtcttttgc attttatcac tctcatttta ttttttaacc ttaaaaaggc
     2521 atagcatatg tttcttctta tttatgggaa ggtttttgat ttaactcttc catcatcttt
     2581 ttatacttct tctcatttaa aggatagaaa caaataataa taatggatag taatataaac
     2641 actcctggca ctaatgcatt catattttta atagcatcta aagaatggag ggtttgttct
     2701 gtatttgcta catatccgtt ctttcctaaa taaagtgctg caaacgatcc tgctaaggca
     2761 acccctagtt tatttgtaaa actcatacta gagattacta ccccatctgc tcttactcct
     2821 gttttccatt ctgcatagtc tacgcaatct gcaaccatcc cccaagcaag tgtattcaaa
     2881 ggtgttgtaa aaaagcctga agcaaagagt aaaataaaga tgaaggtgag agacgaatat
     2941 gatgtaaact gcagtccagc ataagtaaac agcgatagtg ctgctgttac aatcataacg
     3001 ttctttcttc cccaccgatt agagaagtac ggaataaata gattactaat taaagcagcc
     3061 ccgaaaaata gcaatgttcc cataaacact aaatctttac gatcaacatt atacgtaaag
     3121 tagtacacca ttgtacttaa cttaatatta aatccaattg caaaggctaa aaaggatgaa
     3181 gctagaataa gtaatggctt atttttaaat aatactgata acgttttctt aataccgtat
     3241 ttcttacttt ttttcggttt aactctctcg cgaacggtaa agaaactcat aagatttagg
     3301 acaatactta ctgctgcata aatgatagct gttaattgaa acccaacagc ttgattctct
     3361 cctcctaagg cagttgcaag tggtgttgca catgagatgg acagaaggat tccaatataa
     3421 acaagaatca tacgtgttgt tgttaataga gttctttctt ggatgttgtt tgtaatgcgc
     3481 cctgttaaac tgttaacagg aattgtttgc atactaaatg tcatccctaa tagaatatac
     3541 gtaatataag cataggctat gtttccattt gcgccaaaat ccggtgttgt gaaacatagt
     3601 acagtgaata acccaaaagg aatggaaacc cataataaat atggtcttgc ttttccccat
     3661 cttgtatttg ttttatctaa aatgacgccc attataggat caaagatagc atctagtaca
     3721 cgcacaacaa taaataatgt tgcaataatc cccggtgaga ttccaccaat atctgtgtaa
     3781 taaaaaagta gataagcatt tacaaattga aagataatat tgtaggacat atccccaagt
     3841 ccatacccaa atcgttctaa ccatgataag cgagaatttg aataagacag cctcttattc
     3901 gaattttctt gtattacggt tcgttctctc tctatcataa ctacacccct agaatccgtt
     3961 ttcattgtta tgttttgtaa tgcagattaa aagatattaa cctgcacatc tatttccctt
     4021 ttctagttac tgatttggat acacaacaat ttttaaacat tcatttttat ggttgagtgc
     4081 tcgttccata gcttccatcg tatcctctag tccatatcga tcagtaacca atttttcagc
     4141 atcaactatc cctgaagaaa gaaaattaat tccttttgga tatgtgttgg cataacggaa
     4201 gataccataa atatcaactt cattatctgc aataaatgga atattaagag gaatttcatt
     4261 ttgagcaggc agccctacaa ttgcaagtct tccaccacgc cgtaatgaag aaagagcaga
     4321 ttgaagagca gctgggtttc ccgctgtttc ccacgcaaca tctacgccct tgccacttgt
     4381 aatcttgcta atctcaccag caggatcttg ttctgcaata ttaattgtat gtgttgctcc
     4441 catttgtttt gccgcttcaa gtcgtaatgg ttctaagtct gttacgataa ttttacttgc
     4501 cccaactgct ttagctgccg caacagccat taaaccaact ggtcccattc ccatgatagc
     4561 tactatctcg cctgcttgaa gctttgttct tgttgccgca tgaattccta ctgaaaaagg
     4621 ttcaattaaa gctgcttctt catatgaaag ggtatctgga atttgaaaaa caaagtcctg
     4681 tctcattttt atatattgaa caaatgctcc atcaacagga ggagttgcta aaaactctac
     4741 atctggacaa agattatatc ttccttcctt acaggcttca catgcaccac aagtgacacc
     4801 aggttcagct gcaacacgat ccccaacttt cacccgatta acattagctc caatagcggc
     4861 cacttctcct gcgcattcat ggccaagaat aattggtttt tctactttat aatgaccaat
     4921 tcttccatct gtatagtaat gtaaatcaga accacaaatt ccaacagcca ttactttaac
     4981 taaaacctca tcatccttta gttgtggtac tggtaaagtt tcaattcgaa tatctcttat
     5041 actatgcata accgctgctt tcattgttgt aggtacattg ttagtcatca tcattttcct
     5101 ttctaataaa agagttaaga atgtggatcc cttttctata taacactctt tgtttctcaa
     5161 gttgactatc atactcccta gaattatgat gtaagtgcat acattttgga atctgtatta
     5221 tacaatttca ttctatatat ttatctagat atacagtagc tttttacgct gtataaaagt
     5281 acagtctcac tgtacttttc atcttataac caagacagga gtgggcaata tggctgaact
     5341 tgaacggcat gaggagtttg ccgccttgct atcaaagggt gttaagtcat taaagcatca
     5401 ccctaattac aaaataaaaa gaaacagaag tgagagcgct tctttaggtc aatcttattt
     5461 agataagatt gcgtatcaaa taggtgtttc ttctaacact cttaagagtt ggatgggaca
     5521 aatgggttta aaatatatcc cagggcggat agatgatgga aaactttttg gaatcttgtg
     5581 gactattatc aaggaagagt atatgaacaa agaatggttc acaaatgtat tagcaacaac
     5641 ttcaattcct actattacac cgccaattcc tgtttggata acttcttgtt ttaggaaggc
     5701 aaagatatta agaaatgatt cttcatttgg tccaccaaat gaagaagaaa tcaacgaggt
     5761 tatttctaaa ctatttgatt cccctccctc tcatccaaat cctgaaataa aggaagaacc
     5821 gttaatgcat aacttgccta cccgaggatc aggacaattt attggtcgtc accatgaact
     5881 agaagttatt agacaatgga ttcattctcc ttccccagtt tgtcttattg caggatgggc
     5941 aggcatgggc aaaactacaa tagcccttga agctgcatat ttatgtattg aacagttaaa
     6001 cagaaaccag gaatggcctg tgtttaaacg tattatttgg attaatggcg attggaaagg
     6061 attaagtttt aatgacttct tagatacgat tgcctaccaa ctaggacgtg cagagcaaat
     6121 tgacaaatct attgcagaaa aacgccttgt tgttcggaat gtcttggcca tttattctca
     6181 acaacagcct ctacttctta ttgtagatag tatcgacaaa gctgaaagtg agatttatga
     6241 atttgtcatg ggtcttcctc aaggagtgaa ggtcatttta accgctcggg aaaatttaaa
     6301 tcaaaaatat aaagcaggct ttttagaaat aaatacgatt caacttaaag ggtttgagga
     6361 gggagaagca ggagattttt tctcttatga aataagtcga catctccaaa cttacctttc
     6421 ctcaagtaaa aaaacaaaga tagagcaatt atcaaatatt cctttaaatg ttcaaaagga
     6481 gcttatttta gctactgccg gcaatcctaa agcactatca cttagtattg cttatattct
     6541 agataataat atccctgttg aacagcttat ccaaaaaata agaaatgccg gttactctct
     6601 tgttgagcta tttgattttt tatttggcag tacatgggac aagtgtaatg aagatactca
     6661 acgactttgg caagtgctct gtttctttca tagcccccct gatgagaaaa gttgggctac
     6721 agccgctggg ttggactctc gaaaatttta ttatgctgtt gagaagttgc gaactcatgc
     6781 tcttgtacaa cagaattata ttggggataa accacattat ttagcacatc aaacagtagt
     6841 aacttatggt aaacaacatt tagatgctga tgaagatttt gagaaaaact caagaaagcg
     6901 ttggagtcag tattatattc agtatttaga tactcattta aaacgagaac aaccacaatt
     6961 catatattgg agttacttac ttggacggga tttagagaaa attaaacaag aatggcccaa
     7021 tattttaaaa gccttagaat gggcaagtaa acatgctgag aaagaattag taatgaattt
     7081 aattctccgc ctcagccatt ttctaagtcg cgttaatcta ccgctaagaa ttcagtacgg
     7141 gatagaggct gctaattacg ctcatcaaat gaatgataag atttctgagg ctttgattcg
     7201 aattgatatt attggatggg cacttatgga agtaaataaa ttagaagaag catatagtca
     7261 aatagaagaa ggactcctca tattaaaagc aacagatgag attcatcaag aagggcacga
     7321 tcttaagatt tggggacttg ccttaaaatc aaagcttttt ttaaaaacgg agcggataga
     7381 agaagcaaag aacatattaa agaaaatatg taatgtccct gttgcacctg ttatcaaaca
     7441 tcgtgtttta ttaatgcaag gagatttttg tttactgact aaaaattata aagaagctat
     7501 tcatttttat gaattagcaa atgagaaaag tatgttatac ggaggcgaaa aaacgattga
     7561 agcatacttc aacctaggct tagcctatat gcattgcgat ttctatgaaa aagcagaaaa
     7621 gatgttcaat aaccttcttt ataatcaaaa taaacccaat caaattgagc tcatctactg
     7681 ctattatggc aaagctcaaa tacttgctcg aaaaagaaag tacaaggaag catatgattt
     7741 aaatgaaaag gtcattaatt taattcactc atgggaacca actattaata tccgccagga
     7801 agtagagaaa tttcataaat caatgaatga aaacttacta aaaaatacac atataaggga
     7861 tggcatctag ccatccctta tatgtgtata ttgaacattc tttattggac tgattcccag
     7921 cgcgcaacct cttccttcac tttcggcgct actcttgtcc ctaggagctc aatggctctc
     7981 ataacgtctt catgtggcat tgtcccaact ggaacatgaa gcataaagcg ttctattcca
     8041 acattcttac gaagatgaat aattttctcc gctactgtat ctgcatcccc tacgtaaaga
     8101 gctccttcaa aacttcgggc cgcatcgaag cttgagcggt tataaggtcc ccagccacgt
     8161 tcttttccaa gcttgttcat cgcatattgt gtaggaggga aaaacttatc agcagctgtt
     8221 tctgtatcat ctgcaataaa cccatgagaa tgggaagcta cttttaattt ggatgaatca
     8281 tgacctgcat gctctgctgc ttttttatat agctccacaa gcggggcaaa atgaagcggg
     8341 ctgcccccga taatcgccaa cacaagtgga agcccaagaa gccctgctct tataacagac
     8401 tcttggtttc ctccacttcc aatccaaatt ggtaacggtt tttggacagg ccttgggtag
     8461 acacctaaat tctcaatagc tggtctatgc tttccgctcc atgtaatctt ctcagatgtt
     8521 tgtagcttta aaagcaaatc tagcttttca tcaaacagtt cttcataatc tcttaaatca
     8581 taaccaaaga gcggaaatga ctcaataaaa gaccctctcc ctgccataat ctcagcacgc
     8641 ccatttgaaa tgccatcaag cgttgcaaag tcttgaaaaa cgcgaacagg atctgctgag
     8701 gaaagaacag taacagcgct tgttaagcga atattcttgg tctgtgaagc cgctgctgcc
     8761 aatacaacag caggagaaga agcagcatag tcttcacgat gatgctctcc taccccaaat
     8821 acgtctaatc caacttggtc tgccagaaca atttcctcta ctacttctcg aatacgttgt
     8881 gcatgactaa ttacttctcc tgtccttaca tctggagttg tttctacaaa ggtgctaatt
     8941 cctatctcca tttatcgtat cctccttcag aatcacggtc tttatacttg atatttaaaa
     9001 ggaaagtctt ctatcccctt atgcaaagct ttttcccatt gtgaaaattg tgtgatgggc
     9061 actttgcccc agaactgtag tccagacatt tcaaatgaaa cactaataaa atatggatcc
     9121 cctttctctt cacaaccata ccaatgaggg gaatcaacgt gatctcttaa ataacatggc
     9181 aagctcttgt ataccttccc tagcatttca tatgtctctt tattaaattg gtattcatcc
     9241 accatatata ctcgttcaaa ttctaatata tcgtctataa ctttgtagca gttattgtaa
     9301 taatgttcat cttctataat tttgctcacc acgattcttc tccttatgtt atttaacctt
     9361 tatactatct tgtacataag ccctaacaac tgtatttaca gaccaagtag caatagctta
     9421 tatgtattgg aaagagtatt catagattct gtacttgtct taaataaaat gtatgttgaa
     9481 tttctccttt tgtttattct aattaacact gtaatcttaa taataaggcc tcatgtgcca
     9541 ataaaaaagc aatatactca cgtgttttaa aataataatt tgtagttaga gaaacagcgg
     9601 ctagttttta ataccattgc atacattgtt aaagaaaaga aatttattta aataaacaaa
     9661 aacccttcct cggaaatccg agaaaaagac cgtattttta cgttttttta tttatatatt
     9721 aaaagagaat tcgatgttat ccgttaatta ggattgatta ctgattagtt ttttcatagg
     9781 cgattagtca atcctctata aatctacttg agtaaatcgt ttgtcctaaa taactccact
     9841 gtctttccct cttaaaacca agtaaaaaaa cagcactttc cagaaggtgg agtgctgttt
     9901 taaatatgga tatcatttta ttttatgtta aatatgtgga tactttaatg ggagtagttt
     9961 tcttaaccta taactaagta aatatcgccc tataccttaa ttagctgtgc aaacttcccc
    10021 tcagccaagg acgagggcga tagggaccaa ttggaatttg gattaggctg gtctttcctt
    10081 gttgatccat tttatagagt tcatcactca aattcgcgtc aaatccaaga agcggatgcc
    10141 ctcccatccc gagagcttgt gctgccaaaa gcaatcgttg cacgagcatg cctgcttcca
    10201 tctgttggat tcggtagccc ctgtatccta attctgcttt ataaaattcc ttgtccccag
    10261 ccacatgcag gcaaagcggt atctcgagca aattcacatt atccagagac atcccagtct
    10321 gtaaatggag tcgatggtct cctgggcata tttctcttaa catgtgtttc gtgctgtcat
    10381 aatagtacgc cccatttgaa ataccttcaa cattatataa acaactgtaa attgttacac
    10441 gagggacgtt actcctatat gcttcatcta aatcatttcg gtatgaaaaa gaagccgttg
    10501 cttctcggaa aagggtggct agttgttgtt gactcaccat ccccaacacg aaatccatgt
    10561 cgggagaaaa ccgatttctg caggcctcgg ccagatcata tgacagaggc tctatgtgag
    10621 gcaatgccac cgcgggatcc acacgttctg cagttcccct cccccccatc acccgaaatg
    10681 aacgtgtgga atccagctta gaagctgcgt tcattgcagt tatcatcgga tattctttaa
    10741 cactaagtga cctctcgaaa tgttctggtt gaatcgctgg tagctctttt ctcaattctt
    10801 ccgatataat attttcgtat aggttccttc cggtaggaga ccaaatggtg gcttccaccg
    10861 atagtgggat tacactatat atgctctcct cttgctcgga tagtccaagc agatgattga
    10921 ttgcggtatc aagaaattga aagtacaccc ctgaggcgaa gccaaaccgt ttcgctacct
    10981 ccattagctg tccaagcagc acaccagcat ccaacccttg gagtcggtac gcaaagttgt
    11041 tgtatttaaa gaaatttttc cagaacattg tcgacacaaa gacaatacca aaacacgagg
    11101 agatatcaca ccgattgcct agagctctgg ctaaatagga atcgaaattc ccttccctca
    11161 gcaataccag gctatggtgt gctacatcat aatggtagac cccatcaggg agtccctcca
    11221 ccttcaaata tacgtacaat tcattagggt acaacgctcc acctgaagga gcaaaccgcc
    11281 gatacgactg taaagggtag gaatcttgct ccgtggaatc cattggaaag gctgattggc
    11341 tcaattgagt aaaaccaaat acataccaga gaaaatgacc gactctatta aggtccaatc
    11401 ttgcgggagg ttctcctcca gtaagcgtca gcggtacttc cgtggacagt ggaacaaccg
    11461 gtaatccacg atagagctta tatgcaagcg gtgcatcctc ccaatctgct tcccagttcg
    11521 gctgatttgc cttatcaata tcaaaatgca gattgtatag aaattcttcc agactcatcc
    11581 tctacctcct aatcactgct tatggaaacg gatgcggatg tggattgaat tgttcgggtg
    11641 ttaatggttt attcgtatac ccaagctcca tggggactcg gaatactctc tcaagacccg
    11701 tcaggcgggt aaggtgatgc ccgaatgtca tcggcaacat ccccggaatc agtactttta
    11761 cacaatacaa tccgtttcgt atcgtttccg gtgtcgtctg gtctattata actacatcaa
    11821 ggtttaactg acggaacacc tgaaggatgt cttgcaaatc atcggtaaga tcggtatgat
    11881 ttgacttcca cctaaactcc tctttaaaag atcgcattgg gctattgtcg tcaagcaaaa
    11941 agcttaagcg ctcttctgct tgcggcaaac cgtacagcat gccgtggtcc tccatctgcc
    12001 gcactaggga agaatcatgc agcattcttt catactcctc ctggttcgcc tcaaattttt
    12061 catcaagatt cagcatcata ccagcaagct cttgaactgc gcttttcacc gcccgtaccg
    12121 gatccaggtg agctccggcc gcacagatga gattcaatcc cttttccttt ctgtttttag
    12181 caattgccca aatacttgga ataccgtgtt ccattgtgga gttatacaaa tacaaatcat
    12241 acccagcaac cgctcgcatc cgttcgacca ttaattctaa ttcctggtcg ccagctgtaa
    12301 aaggatccag tcgcggaagg ttcagcttcg cgtaccaagt catcaggaat gaatcacgtt
    12361 cgaccacttc cataattccg tagaaaatgg cctcctctaa acttcctcct agcgcacatc
    12421 cattggaagt ttcatagata aaaccttgtg acgcgcatcc aacactgtaa taggcaagga
    12481 gttctggaac tagaattgga cgcccttcta acaacgaata accccatacc caattaatag
    12541 aacgatcagg atcgaacgat ttaaatggaa aactaggctg cgcatattgt tcttttgcat
    12601 gtacgcctac cttcaatgga ttgagcgctt gattttccag gttatgaaaa ctatcatgga
    12661 tcactgtccg tttgccacgt ggttctaaac cgcaatgtcg ctccaatccc tctaaaatgg
    12721 ctgtcaacac actttctgca tatgaatgag tccggccagc tgttccctcg tccccgtcaa
    12781 acataggaag attaacactc gcatcagcaa atggagtcac taggtcatac attttactat
    12841 tcaaaaggcc ggtacgatta tccagatagt ctttgacaat aacttttttc atctcatcca
    12901 actgacggca tcgaaaaata ctggaactga gtttcgggct tggctgcagt gaaattcggg
    12961 ctaatgtctg tgaatcgtcg ggtaatcgac cacagaccga acacaacggg ttcggcagaa
    13021 aagaatgcca tgagctattc agtgttttca agtcaattag atatatctta ccttccgaat
    13081 aagcctgatt accttgtaat aaattctgta cctcaacccc aatcaggtaa gccatttgca
    13141 aaaggccggt acttgaagcc cacgggtcac ttcctattcc tccggtcaca gccagcctct
    13201 gttgcacctg ttgcatctct gtgcgatcac gtcctcccat gagacgtctc atgtccgcac
    13261 attgggagca acctgctgca cctggtcgta cgagcggacc aactacacct tctccaaatg
    13321 aaacgaagcc tctgagccag ggagtaccag tctttcgtaa cacttcttcc gccttttgat
    13381 gaacagaggg ttcccaatcg tcatccaaaa aaagagccaa atcagtattc tttggcacgc
    13441 cttcctcaaa attgggctta cgaataacta gatggtgtgc tgacagttct tcgcttacaa
    13501 ggtccgccag caccccttct ccgacaacca gcacgaagga actcaatgtg attcctcctc
    13561 tcgcagcaaa acaccaaaca ctccgtctag ttgctcttta aaaacaggtt cgatccctaa
    13621 ttcaaatact aagacccttt ttcctttatg ctccaatatt tccatagctt cctttaggat
    13681 atccgcttgt atcctctcgt cacatgcagg aatgctaaga ctaattggca ttttctcttc
    13741 caaaagtacg gacgttacct cacaggctag ttcattagag gaatccggtt tgttttgcac
    13801 tttgataagt gcctgttgca atgccttccg taacgccatt gttatattta aatctgcact
    13861 gccataccat ccatcttttg tacctaccca tactacagga aaaccgaata attcctttcc
    13921 tcttccgata attggtgctc cctgcatcgt agtcagtgcc tctaaataga accggcatct
    13981 ctcatcttct ataacactca actgtactcg agaaacagaa tacttctgat taagttgttg
    14041 cttgctaagt tcctctgcca aacacttttg caatccacgg ccaacacctt ccacaaaaga
    14101 ttcaccagct ccaaccccga caatatcctc cggtactact acacttccat caacattttt
    14161 atttagcggc agagtattaa cgatcaaact gaccattcgt gacacatacg tttcaatccc
    14221 agttagtcct gcttctcttc gtgcctcctc atgagtcaaa cctgaacaga caatgtcttg
    14281 catcaactca gctggtccct ccgacaacgg gtcgactgcc tgaacgcggc actgagctaa
    14341 cggaagctgc tttaaatctc cctcctccca aatatgaaat attcccgatt cctctgatgt
    14401 caactggttg aaataaagta gtaatttacc tgactcaact ttctctaagc ctacttggag
    14461 acggcttccg acatcttcaa cccattctgc agatatactg cttgttacca gtgggtgagg
    14521 taaaaacgaa tgccagtttc cctccaatgt atctaaattc agaagaaaaa ccctattttt
    14581 ctgttccaat tccatgacac ctgtaacctc tttaaacaat tcaaatacga tcacattggc
    14641 taacaacgat cccggagtgg cagagaaggc agggaattgc ccatttttga ataaggcaga
    14701 atggtgtaaa cggcgccatg ctgtctccca acacacctcg gaatctggat gtactaatgg
    14761 acctgctaaa cctacctgtt gcagacatat agcggggaga aacattttct tctcttccct
    14821 gcaaactata tgaagatgtc taagttcctc aagttctccc tcctgactca catacaaaat
    14881 cgaatcaaag ggcttcacta tttctcgcca tccctccttc ttttgtggaa tctcctttaa
    14941 gtcaacctct gagtctattt ttcgtgcatg ttccacaagt tcttttaatc tctgtctatt
    15001 ggtgggaacc tcatctgtga ttagcactcg gaccttagtc aaaccagatt caatcaacga
    15061 agaaaccaat gaatttaaaa taggaccaga gccaactgcc agcactttgt tctgacgaaa
    15121 atcttgaaaa cgggccgccc cagaaccaac taaattgtcc acaaattcaa tttgagatgc
    15181 atgcttttta agttgataac ctgacaattg atgcggaagg tcctgactta aatctcgaac
    15241 atacccattc gtatacagca cttctgcgat ttcatatacc cgttcccgat atggtccagg
    15301 caatccgtta gtcaaattcc ctaaagtata ctccccattg aacatcggta acaacttttc
    15361 aatccactga tcgatcccac tgccttcgat acggaatgaa cttaagttgt ttcgaaaata
    15421 cacacctctg tttggttcag ggagatagaa cgtgtccctc ttcactttca gacgcataga
    15481 agggttcaaa tttgtcatct ctctcctcct taccccttgt aaccataaat gttcaatatc
    15541 actaccatta tcatcgtatg tacagcaatt tgtccgttat gtctcatctt atagagaaag
    15601 acccctgcaa caatgcaggg gtccttctca aatagaaaaa taaactacta accggcttag
    15661 ctgccgccac cacaacggcc accgccacca caacggccac caccgccgca tctagagcaa
    15721 cgagaacaat taaagcaatt aaagcagtta aaacagttaa aacagttaaa acagttaaaa
    15781 cagctaaagc atctaaagca tcggccaaaa ccaaatccca caccaacaat ttgtcgatcc
    15841 tgatcagtat agtactgatt ttgatcccaa gtgactgcct gagtcgcttg gaaatcacca
    15901 acattcaaca tttgaagttc attttggaaa tcattcattt tcttttcctc ctcaaataaa
    15961 ttaacaaagg tgccagcaat ttaaaacggg aacaaccgag ttaaatagaa aaaactgtac
    16021 accagatgaa tacattaaat gtttcaaata ctcttcaaca aattatgtac aatagatggg
    16081 tattgttact gatacaaaag cctaatttaa agaaactgga aaaagccgtt caaaacgaaa
    16141 acaggatgat tataaaaaaa acgcctgaat cggcggctga atcatcaaaa ctggtgtatt
    16201 atttttagct attcatatgc tcaatacttt taccttcaac aacggcttta tttgctccaa
    16261 tcgacagcct cgcgacaaat ataaacataa gcattgcact aagcaattgg acgctttgga
    16321 gcatcgtaaa gaaccaaggg actggacggt taaagtctct acacttgata aaatactcat
    16381 ttccaccgcg ctgatatcct tctcagtaaa attggactct tttatgttaa ataaaagttc
    16441 ctttgtagct gtagaatact gttttttcct tgctttatta cgtaaagttt ctattaaaaa
    16501 tacattaaag atattattat ctgaagcaac tgttaaaaca aaaaggtata actatgactg
    16561 aattgtatga gattacagaa atctctcaga atgctttgat ccttatttca aatggtaaaa
    16621 gtaatggaat tcaatttaat acattagata aaatactaga agcaactaat tccaaaattg
    16681 aggaacttat tgaatatggt gaggagctat attctctttt tatcagatta gaacataata
    16741 acagcaagaa tctaatttct taggttgggg attcaaaggg tagtcatttt acatctaaat
    16801 aaataaaaaa ccctttctcg aaaatccgag aaagggttgt aaaacgttga tatataaaaa
    16861 atattaacgt tttgagaact gaggtgcacg acgagcgcct ttaagaccgt attttttacg
    16921 ttctttcata cgagcgtcac gagttaatag accttcaggt tttagtgttg cgcgatattc
    16981 tgggtctgct tgtaatagtg cacgagcgat accgtggcgg attgctccag cttgaccagt
    17041 gaatcctcca ccgtttacgt ttactaatac atcatagttc ccaagagttt ctgttgcagc
    17101 aagaggttgt tttacaactt ctcttagtgc tgccgatgaa agatagttct cgatttcacg
    17161 accgttaaca acgatgtttc cgttacctgg tactagacgt acacgagcaa cagagctttt
    17221 acgacgacct gttccgtaat attgtacctg tgccaatata attccctcct tacgtattat
    17281 ccgcgaagtt cgtaaacttc tggtttttgt gcttcatgtg gatgagtgtc tcctgcaaac
    17341 acatgtaatt ttttaaacat ttgacgacct aagctacctt ttggaagcat tccacggatt
    17401 gctagttcaa gcattttctc tgaatagtta gtacgcattt caagagccgt gcgagattta
    17461 agtccgcctg gatgttggct gtgacggtag taaatcttgt cagtcaattt tttacctgtt
    17521 aattcgattt ttgctgcatt aagaatgatt acatgatcac cagtatcaac gtgtggtgtg
    17581 taagttggtt tgtgtttccc gcgtagaata gaagcaactt cgctagcaag acgacctaaa
    17641 gttttacctt ctgcgtcaat tacaagccat ttgcgctcta cttcacttgc tttcgccata
    17701 taagttgtac gcatgtttta ccctcctaga atttcaactt tcgaacgttt tattttaaac
    17761 acgattaatt tccggggcta atcgtgggtt taaaattaca tacatatgtt atattagcct
    17821 gttgtattcc caatgtcaag aggatgttac accaggttta gttgtcatag taaactttcc
    17881 acaagtatag cccatgtcca ggtgcagttt tgcctgttag agtgcgattt ttcgcctcta
    17941 gcatccctga aatatctttt gtgaaacttt ttccgctacc aagatcaaga agtgttccca
    18001 ctagaattcg gaccatatta taaagaaatc cgtttcctac aaatctaaat gtaagcacgt
    18061 ctccttcttc aataatttcc gcttcataga ttgttctcac tttatcttct atctccgtct
    18121 ttgctgaaca aaaacttgta aaatcatgtg taccaattac gctctttata gcttccttca
    18181 tcaccttacg atctaactcg tatggaacat ggtgcatata atgccttaag aacacatcgc
    18241 gacttttgct gcaaagcact ttgtaacggt attccttttt tttcacgcta aaacgagcat
    18301 gaaaatcttc tgacgtttcc tttgtatcaa ctactacaat atcttctggc aagagcgcat
    18361 tggctcctcg ctcaagctgg cttacgctga tagtacttat agtatcaaag tgaaacacct
    18421 gccctttagc atggacagac gcatctgtgc ggcctgaggc atggattttt acttccttac
    18481 ctccatggag acgggtaagg gccttttcaa tctcttcttg cacagtacgg gcattaggct
    18541 gaatttgata gcctgaaaaa agtgttccgt catatgctac agtacattga attcttcgca
    18601 tctctcacat ctcctagact cttacgataa atagagcagc agcaacaata acaaatatga
    18661 taagggccat ggtatcaata gccccccagc taagctgacg atactttgtc cgtccttctc
    18721 caccttgata ccctcttgct tccatagctg ttgctagctc ttctgcacgt ttaaaagcac
    18781 taataaaaag cggaattaag agtggcacaa cggcctttag acgatcttta agaggcccgc
    18841 tcgaaaagtc tactccacgt gctgtttgag ccttcaagat tttgtctgtt tcatccatca
    18901 aagtgggaat aaaacgaagc gaaatagaca tcataagtgc taattcatga acagggaaac
    18961 ggactttctt taatggatgt aaaagtgtct ccatgccatc tgttacctca attggtgttg
    19021 ttgtaagagt taacagggtt gtaagtaaaa ttaaaaataa gaacctaagc gaaatataaa
    19081 tcccttgaat aactccgcct tcatagatct tcagaaaacc aatatctgcg attacttctc
    19141 cttccctcgt cataaaaata tgaaggagaa aggtaaaaat aataataaac aatattggct
    19201 ttagcccttt aataataaaa taaatcggaa ctcgacttac aagtactgct aaaatagcaa
    19261 acaaaccaat aatgctgtag cttacaatat tattcgcaag aaaaataaca gctacataga
    19321 aaaaaacgat aataagcttt gcacgaggat ccatacgatg aataaaagaa tctcctggaa
    19381 catactgacc aataatcata ttattcatca tgagcttgtc ctccaaaaag ctttgtgacc
    19441 tcttctacgg ccttttgaaa tgtaatagcc ccgtgactaa gggagacgcc caaacgctgt
    19501 tctagatcca atatgaactg cagaggctct ggaatatcta atccaatctc tttaagcttt
    19561 tcatattgct taaagatttc ctttggtgtt ccgctcattg aaactttccc tttatccatt
    19621 acaataatgc gatctgcata ttgtgctgca tcttccatac tgtgcgttac aagtacaatc
    19681 gttaatcctt gttctttatt taaagaggag attaaattca taatctcatt acgccctctt
    19741 ggatcaagtc ctgctgttgg ctcatcaaga acaagcactt gcggttccat cgctaaaatc
    19801 cctgcaattg ccacacggcg catctgtcca ccgcttaaat caaacggtga tttctgcaga
    19861 acttcctttg gcaaaccaac tattgtagca agctcatttg cccttttttt cgcttcctct
    19921 tctgaaaccc caaagttcat cggaccaaaa caaatatctt tttcaacagt ctcatcaaag
    19981 agctgatgtt caggaaactg aaagacaacg ccaacgcgtt tgcgaatttc ttttaaatgc
    20041 ttttccttct taccactttc aattgtacga tctcctattt gaatactccc tttagttggc
    20101 ttcaaaaggg cattcaaatg ctggataact gttgacttac cagagcctgt atgaccgatt
    20161 aacgatacga actgaccaga gggaatggat agtgatacat cttctaatgc taatcgttca
    20221 aaaggtgttt taagctgata acgatgttct acatttttga atataatctc catagttcct
    20281 ccactaagtt gtccgttgtt aaatgaatat attctaaaga aattcctttg tctcttagaa
    20341 catgactaat ttgactagca aatggaaaat caaggccaat ctcagtcaat ttgctgccaa
    20401 gttcaaaaat ctctgaaggt gttccagttg caaaaagttc tcctttattg aggacaattg
    20461 ctctatcagc tttcgctact tcattgaggt catgggtaat ggagataatc gttagattgc
    20521 gttgattttt taacaaacga atggtttcga gaacttcact acgtcctttt ggatcaagca
    20581 ttgatgttgc ttcatctaaa aggataacat caggtgccat tgcaacaaca ccagcaatac
    20641 caattcgctg cttctgacca ccagatagac gatgcggctc atacttctcg aaccctttca
    20701 ttccaacaac ttcaattgct tcccctactc tttttctcat ttcttcatac ggaaagccat
    20761 tattctctaa cccaaaagca acgtcgtctt caactgttga acctacaaat tgattatcag
    20821 gattttgaaa taccattcca atatggcgac gtacatccca tacagaatct tctgtaagca
    20881 taagatctgc tactttcaca gaaccttgtt caggtagaat gaggccgttt aaaattttag
    20941 caagcgttga tttccctgag ccattatgtc ctgcaattgc aagccattct cccttataaa
    21001 cgttaagaga taagttgttt agcacataag gtccatcttc ttcgtaccga aaatacaagt
    21061 ctttcacttc tatgactgag tttgacatat acagccccct ctactatgct cctctaagct
    21121 aattcgtttc aacatataaa aaaagggcat tgagcagttg agaataactg tcacgccctt
    21181 gtagcaccta tattgttcaa atgggcgtca gacactttct ttaaaaaaga agagaatcca
    21241 tacgccctaa gaacttcata tattaaacta actcgatgat agccattgga gcaccgtcac
    21301 cacgacgagg tccaagtttc ataatacgag tgtagccacc ttgacggtca gcataacgag
    21361 tagccacgtc gctgaaaagt ttttgaacag cgtcttgacc agtctcttcg tttgctactt
    21421 cgtggcggat gtatgctgca gcttgacggc gagcatgtag atctccacgt ttaccaagag
    21481 tgattagttt ttctacaaca gacttaagtt cttttgcttt tggttctgtt gtttcaatgc
    21541 gctcactgat gattaagtca gttgctaaat cgcgaagaag tgctttacgt tgtgcacttg
    21601 tacgacctaa tttttgatat cccatgagta tttccctcct tcgttactaa ttcgctatct
    21661 atcaatcgtc tttacgtagt ccaagaccaa gctcttcaag tttagctttc acttcttcaa
    21721 gagatttacg tcctaagtta cgtactttca tcatatcttc ttctgtttta ttcgcaagct
    21781 cttgtactgt gttgatgcca gcacgtttta agcagttgta agaacgtaca gaaaggtcaa
    21841 gttcttcaat cgtcatttca agaactttct ctttttgatc ttcttctttt tcaaccataa
    21901 tctctgcttt ttgtgcctca tctgttaatc ccacaaagat gtttaaatgc tctgttagga
    21961 ttttagcacc tagtgctaca gctttttcag gctcaatact accgtcagtc caaacatcaa
    22021 gcgtaagctt atcgaagttt gtcatttgac caacacgtgt attttcaaca tagtaagaga
    22081 cgcgcgtaac aggcgtgtag attgaatcaa ttggaattac accaattggt tgatcttcat
    22141 gcttgttctc aaccgcagca tcataaccac gacctgtttg agctgttaga cgcatgcgga
    22201 actgtgcatc tgtttcaagt gttgcaatat gaagatctgg atttaagatc tcaacatcac
    22261 tatctccttg aatgtcagca gcagttacaa cacctttgcc ttgaacatca atttctaacg
    22321 tcttctcttc atcagagtag atttttaatg caagcttctt cacatttaaa atgatgtttg
    22381 ttacgtcttc aacaactcca ggaattgttg agaactcatg taaaacacca tcgatttgaa
    22441 tagatgttac agcagcacca gggagagagg ataataggat acgacgtaag gagttaccca
    22501 aagtagtacc atatccacgc tcaagtggtt cgacgacgaa cttaccgaac tttccatcat
    22561 cgctgatttc taccgtttcg atttttggct tttcaatctc tatcatttat taaaccctcc
    22621 ttcaaaacgt cgaaacccca gttagatcat ttagatccta aatgatctaa ccgaaattcc
    22681 ctcttagaca gttcccgaat gtgcacaaca tttgaccgga aaaaaatctg tatcatatcc
    22741 cattatagac gataaaatga aatatataca gatgaattaa ttatacacga cgacgttttg
    22801 gcggacggca tccattatga ggtactggtg taacatcttt aattgctgtt acttcaagtc
    22861 ctgctgcttg aagagcacgg atagctgctt cacgaccagc accagggcct ttaactgtaa
    22921 cctctaatgt ttttaaacca ttttccatac ctgttttagc agctgtttca gcagccattt
    22981 gtgcagcgaa tggagtagat ttacgagatc cacggaatcc aagtgcacca gcactagacc
    23041 aagaaatcgc attaccttgc atatcagtga tcgttacaat cgtattgttg aaagttgaac
    23101 gaatgtgagc gatacctgac tcaatattct ttttcacacg acgtttacga gtgtttgttt
    23161 tacgagccat gttggataac ctcccttact tattatttct ttttgttagc tactgtacga
    23221 cgtggacctt tacgtgtacg agcattgttt ttagtatgtt gaccacgaac tggtaagcta
    23281 cgacggtggc gaagaccacg gtaagaacca atttcgatta gacgtttgat gtttagagaa
    23341 acttcacgac gaagatctcc ttctacttta tatccgtcaa caatttcacg aattttattt
    23401 aattcatctt ctgttagatc gcgaacgcga gtatcttcag aaacgccagc ttcagctaag
    23461 attttttgag ctgttacttt accgattccg aaaacgtaag tcattgagat aactacgcgc
    23521 ttatcacgag ggatatctac acctgc
//
