LOCUS       NZ_CP063142            20879 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Priestia filamentosa strain GN1 chromosome.
ACCESSION   NZ_CP063142
VERSION     NZ_CP063142.1
KEYWORDS    RefSeq.
SOURCE      Priestia filamentosa
  ORGANISM  Priestia filamentosa
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Priestia.
REFERENCE   1  (bases 1 to 5133640)
  AUTHORS   Buch,A., Patel,D. and Chandnani,M.
  TITLE     HCA producing B. filamentosus GN1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5133640)
  AUTHORS   Buch,A., Patel,D. and Chandnani,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAY-2020) Department of Biological Sciences, P D Patel
            Institute of Applied Sciences, Charotar University of Science and
            Technology, Changa, Anand, Gujarat 388421, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. v-3.13.0
            Assembly Name                     :: CHAR_BFil_1.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina Nextseq500
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022811745.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 08:14:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,159
            CDSs (total)                      :: 5,093
            Genes (coding)                    :: 5,023
            CDSs (with protein)               :: 5,023
            Genes (RNA)                       :: 66
            rRNAs                             :: 2, 1 (5S, 16S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 70
            CDSs (without protein)            :: 70
            Pseudo Genes (ambiguous residues) :: 0 of 70
            Pseudo Genes (frameshifted)       :: 21 of 70
            Pseudo Genes (incomplete)         :: 52 of 70
            Pseudo Genes (internal stop)      :: 15 of 70
            Pseudo Genes (multiple problems)  :: 15 of 70
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:46:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 896439
            Orig. end                         :: 917318
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP063142.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr Aditi Buch, Department of
            Biological Sciences, P D Patel Institute of Applied Sciences,
            CHARUSAT.
FEATURES             Location/Qualifiers
     region          1..20879
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20879
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20879
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10879](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10879
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            145..657
                     /gene="spoIIIAB"
                     /locus_tag="HPB58_RS04630"
                     /old_locus_tag="HPB58_04630"
     CDS             145..657
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013084997.1"
                     /locus_tag="HPB58_RS04630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04630"
                     /product="stage III sporulation protein SpoIIIAB"
                     /protein_id="WP_243517746.1"
                     /transl_table=11
                     /translation="MKLFGALFILVATTWFGFDLAKQLNARPKQLRQLKSALRSLEAEI
                     MYSHRPLPQIARLLTEQVPKPIASFFDSFATYLEKGQKSAGEAWLLSIEENWRLTALKQ
                     GEKEALKQFGQTLGQHDRYSQQKHIVLTLNHLEREEADAVDRQTRYEKMVKSLGFLTGL
                     LLVILLL"
     gene            678..884
                     /gene="spoIIIAC"
                     /locus_tag="HPB58_RS04635"
                     /old_locus_tag="HPB58_04635"
     CDS             678..884
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_390321.1"
                     /locus_tag="HPB58_RS04635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04635"
                     /product="stage III sporulation protein AC"
                     /protein_id="WP_019391532.1"
                     /transl_table=11
                     /translation="MGVDINTIFQIAGVGIIVAFLVTVLEQMGKKDFANWVTLIGFIYI
                     LFMVASIVQDLFQKIKSVFLFQG"
     misc_feature    720..733
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.73"
                     /tool="antismash"
     gene            906..1292
                     /gene="spoIIIAD"
                     /locus_tag="HPB58_RS04640"
                     /old_locus_tag="HPB58_04640"
     CDS             906..1292
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003249238.1"
                     /locus_tag="HPB58_RS04640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04640"
                     /product="stage III sporulation protein AD"
                     /protein_id="WP_019391533.1"
                     /transl_table=11
                     /translation="MIQIVGLGLIATFLTIILKEQKSSIAFLLVVFVGCVIFLFLVDKI
                     SEIIGMVEVLSRQAGVNVIYVETILKIIGIAYIAEFGAQITKDAGQGSIASKIELGGKI
                     LILSMAIPILTVVIETIISMLPTT"
     gene            1316..2488
                     /gene="spoIIIAE"
                     /locus_tag="HPB58_RS04645"
                     /old_locus_tag="HPB58_04645"
     CDS             1316..2488
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013059149.1"
                     /locus_tag="HPB58_RS04645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04645"
                     /product="stage III sporulation protein AE"
                     /protein_id="WP_243517748.1"
                     /transl_table=11
                     /translation="MKKKKSLFCLVLLLFLFFLPDSVQAFPNADEMVDEQVDQLGIDEI
                     KGFWNNIMTEYGGFLPESQKGSLVEFLKGDKELSLEEWLKGLMKFFLHEIIANGKLLGT
                     LIMLTIFCVFLQNLQNAFEKTTVSKVAYALVYLVLIVIALNSFHIAISYATEAIQTMIH
                     FIIALIPLLLALMASSGGVMSAAFFHPVIIFLMNTSGLLIQYVVMPLLFLSALLSIVST
                     ISEQYKVTQLAQLMRNVSIGVLGGFLTIFLGVISVQGTSSAVADGITVRTAKFITGNFV
                     PVVGRMFTDATDTVLSASLLLKNTVGLVGVAILLFITAFPALKLLSIAIIYKLAAALIQ
                     PVGGGPIISCLSIISRSVIYIFAALAVVSLMFFLCITLVITASNITMMVR"
     misc_feature    complement(2500..2514)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.05"
                     /tool="antismash"
     gene            2500..3135
                     /gene="spoIIIAF"
                     /locus_tag="HPB58_RS04650"
                     /old_locus_tag="HPB58_04650"
     CDS             2500..3135
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013059148.1"
                     /locus_tag="HPB58_RS04650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04650"
                     /product="stage III sporulation protein AF"
                     /protein_id="WP_243517750.1"
                     /transl_table=11
                     /translation="MGALTEWVTNIILFILLATIIDLLLPSSSMQKYAKMVIGLLLMLI
                     ILTPVFSIFKVNVDKLFTAINSSSISQENSSKNLLDLKKKEIQASQDAYILEQMAVQLE
                     EGVKEELVKEYGVEVSGVEIHMKDEKGEKSFENISSISLSVQPKENKHTASVSEVEVVS
                     INTSEPIKKEKTENDEKLKKVQSFLSKKWDMDKKQIIVTMGGGEADER"
     misc_feature    2501..2515
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 19.47"
                     /tool="antismash"
     gene            3125..3790
                     /gene="spoIIIAG"
                     /locus_tag="HPB58_RS04655"
                     /old_locus_tag="HPB58_04655"
     CDS             3125..3790
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIIIAG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391536.1"
                     /locus_tag="HPB58_RS04655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04655"
                     /product="stage III sporulation protein AG"
                     /protein_id="WP_243517752.1"
                     /transl_table=11
                     /translation="MSDKESNKKKNFLARLSSSDPPKKNRKLAYVILLLAAGVFVMLYG
                     NFQSSTTKPDAVETKGSGDSQQETEEVETFGSGKEKQARTISDYEKKYEAELTDVLESM
                     MGIDNVQVFVNVDATEEKVYEHNTVNQSQTTEENDREGGTRNIEDNSVDQQLVIVRNGD
                     KEQPVVVKTLKPDIRGVLVVAKGADNIKVKKSVVDAVTRVLDVPSHRVAVTPKKTKGD"
     gene            3796..4374
                     /locus_tag="HPB58_RS04660"
                     /old_locus_tag="HPB58_04660"
     CDS             3796..4374
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391537.1"
                     /locus_tag="HPB58_RS04660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04660"
                     /product="SpoIIIAH-like family protein"
                     /protein_id="WP_276517227.1"
                     /transl_table=11
                     /translation="MLLKKQTVWLLTMLSLVVVLSVYYITSPSPQSDNVAFTDKEESKE
                     KESAKQTDKETEQKGASTTEKNGETVVSTVENEDQFLAMRMQITDERSKEIEKLEDVVA
                     SNEASVEEKSEAKDKVEELSKLNEKEQTIETLIKEKGYDDALVRAEENGVRIVVKSKED
                     SKKQANEIMNIVTQEIGAKKVAVEFEPIK"
     gene            4618..5109
                     /gene="accB"
                     /locus_tag="HPB58_RS04665"
                     /old_locus_tag="HPB58_04665"
     CDS             4618..5109
                     /EC_number="6.4.1.2"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="accB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008358617.1"
                     /locus_tag="HPB58_RS04665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04665"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="WP_019391538.1"
                     /transl_table=11
                     /translation="MLKIQEIREIIRLVDQSSIEEFMYEHEGSKIKLKKKGALAAQQKV
                     VIQEQPVQQIPAQPSVQPVVQQNEPQQPVHTEEKKEESNLHKITSPMVGTFYNSSSPEA
                     GPYVQTGTKVKQDSVVCIVEAMKLFNEIEAEVTGEIVEILVENGQLVEYGQPLFLVKPE
                     "
     gene            5123..6478
                     /gene="accC"
                     /locus_tag="HPB58_RS04670"
                     /old_locus_tag="HPB58_04670"
     CDS             5123..6478
                     /EC_number="6.3.4.14"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_function="GO:0004075 - biotin carboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="accC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015375375.1"
                     /locus_tag="HPB58_RS04670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04670"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_243517754.1"
                     /sec_met_domain="RimK (E-value: 8.1e-08, bitscore: 30.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 1e-06, bitscore: 26.6,
                     seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1e-08, bitscore:
                     33.2, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKKLLIANRGEIAVRIIRACKELNVESVAIYSEADKESLHVRLA
                     DEAYCVGPTASKDSYLNFTNIMGVAMLTGCDAIHPGYGFLSENADFAELCRECNVTFVG
                     PTSESISKMGTKDVARETMREAGVPIVPGSQGIIESVEDAVTIAEEIGYPVIIKATAGG
                     GGKGIRVARDESSLRKGVEITQQEAATAFGNPGVYLEKYIEDFRHVEIQVLADEFGNTI
                     HLGERDCSIQRRLQKLVEETPSPALDGEMRAKMGEAAVKAAQAVQYRGAGTVEFIYDYR
                     ERKFYFMEMNTRIQVEHPVTEMVTGIDLIKEQIKVANHEKLSYTQEDVTFSGWAIECRI
                     NAENPAKNFMPSPGEINMYLPPGGFGVRVDSAVYSGYKIPPFYDSMIAKLIVHAPTREE
                     AVARMRRALSEFVIEGVDTTIPFHLNLFQHEKFIEGEFNTKFLEEHEVMKSK"
     gene            6499..6903
                     /locus_tag="HPB58_RS04675"
                     /old_locus_tag="HPB58_04675"
     CDS             6499..6903
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013059143.1"
                     /locus_tag="HPB58_RS04675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04675"
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="WP_019391540.1"
                     /transl_table=11
                     /translation="MNENHVLDMGENENALGKVEIAPEVIEVIAGIAASEVAGVGQMRG
                     NFASGVVEKLGKKNHGKGVKVELSEEGIKIDVFCSMNYGVSIPTVASQVQDNIREALKN
                     MTALELAEVNVHIVGVIFESPQKEEEIDSI"
     misc_feature    7033..7050
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.7"
                     /tool="antismash"
     gene            7089..7478
                     /gene="nusB"
                     /locus_tag="HPB58_RS04680"
                     /old_locus_tag="HPB58_04680"
     CDS             7089..7478
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="nusB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009373884.1"
                     /locus_tag="HPB58_RS04680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04680"
                     /product="transcription antitermination factor NusB"
                     /protein_id="WP_040056772.1"
                     /transl_table=11
                     /translation="MKRRTAREKALQALFQCEIGQNSPEEAIDNVVEEEAVDAFLRQLV
                     LGVSENKEEIDSLISANLEKWTLDRLANVDRIILRLAVYEMKYEEDIPQNVSINEAIEL
                     AKTFGDDQSGRFINGVLSKISASNS"
     gene            7553..8404
                     /gene="folD"
                     /locus_tag="HPB58_RS04685"
                     /old_locus_tag="HPB58_04685"
     CDS             7553..8404
                     /EC_number="1.5.1.5"
                     /EC_number="3.5.4.9"
                     /GO_function="GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /gene="folD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391542.1"
                     /locus_tag="HPB58_RS04685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04685"
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD"
                     /protein_id="WP_243517757.1"
                     /transl_table=11
                     /translation="MSAQLINGKELASEKRESMKKEVEMLKEQGVKPGLAVILVGQDPA
                     SETYVRSKHRACENTGIHSVSIKLPDTVSEEELLGHIDKLNEDDAIDGILVQLPLPKHI
                     NEDAVIERISPKKDVDGFHPISVGKMMIGQETFLPCTPHGVLEMVRKTGIEVSGKHVVV
                     IGRSNIVGKPVGQLFLNENATVTYCHSRTQNMQKHTRDADILIVAVGIPNFVKAQDVKE
                     GAVVIDVGINRVDGKLCGDVDFEEVKEVAGAITPVPGGVGPMTITMLLENTIQSAKARV
                     RS"
     gene            8423..9772
                     /gene="xseA"
                     /locus_tag="HPB58_RS04690"
                     /old_locus_tag="HPB58_04690"
     CDS             8423..9772
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009373881.1"
                     /locus_tag="HPB58_RS04690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04690"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_019391543.1"
                     /transl_table=11
                     /translation="MSELKPLTITALTKYIKRKFDVDPHLQDVWLKGEISNFKQHSRGH
                     MYFTLKDEHARMSAVMFSSQNKNLPFTPENGMKVLARGEVSVYEGSGNYQLYIRDMQPD
                     GVGSLHLAYEQLKNKLEGEGLFDPRIKKPLPLYPNLVGVVTSPTGAAVRDIMTTIKRRY
                     PVAQIILIPALVQGDRAPASIVSGIKKAKDINADVLIIGRGGGSIEELWGFNDEKVARA
                     IYESTLPIISAVGHETDFTIADFVADMRAPTPTAAAELAVPNLTEVLERISQRKIRLTR
                     AISSHITAKKTRLERTEKSYAFRYPTKLLEQKEQQLDLLLDRLHKESKRIAMRKEEKFS
                     YIKRRLLTHHPYARLKEADRERERLTRLLQKDITTVLNAKKMLLSSQMAKLNALSPLKI
                     MERGYSLVYNEEEKLVKSTKGVAKGETVTLRLKDGSIDCLVEDIRSGENE"
     gene            9765..10004
                     /locus_tag="HPB58_RS04695"
                     /old_locus_tag="HPB58_04695"
     CDS             9765..10004
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017755722.1"
                     /locus_tag="HPB58_RS04695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04695"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_019391544.1"
                     /transl_table=11
                     /translation="MSEEKEYTFEEAMEELEKIVDKLEEGDVPLEEAIDRFQEGMKLSK
                     FCHDRLQKIETQMEQILQEDGNLAPFSVGEEGDK"
     gene            10001..10879
                     /locus_tag="HPB58_RS04700"
                     /old_locus_tag="HPB58_04700"
     CDS             10001..10879
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391545.1"
                     /locus_tag="HPB58_RS04700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04700"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_243517759.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.7e-61, bitscore:
                     206.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIALESYLKEYKKLVEELLPTQIEALQMPSLLKESMLYSLTAGGK
                     RIRPILLLATLEAFGKDKSLGYEAACAVEMIHTYSLVHDDLPSMDDDDLRRGKPTNHKV
                     FGEAAAILAGDALLTYSFQIVTKANLSPEIKLLVIEELARAAGAEGMVGGQMADIEGEE
                     KKLSLKELEYIHEHKTGKLLSFGIIAGAIIAGASEDQLSHLKHFSYHLGLAFQIQDDIL
                     DIEGNEQLLGKPVGSDTGNDKATYPALLGMENAKEKLKYHMDQAIMELEKAEIQDSMLK
                     ELSYYIAWRQQ"
     misc_feature    complement(10960..10973)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.9"
                     /tool="antismash"
     misc_feature    10960..10974
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.5"
                     /tool="antismash"
     gene            11083..12987
                     /gene="dxs"
                     /locus_tag="HPB58_RS04705"
                     /old_locus_tag="HPB58_04705"
     CDS             11083..12987
                     /EC_number="2.2.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009240 - isopentenyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dxs"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391546.1"
                     /locus_tag="HPB58_RS04705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04705"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_243517761.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 1.4e-118,
                     bitscore: 393.3, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.1e-05, bitscore:
                     22.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLTSIKNPAFLKKMSTSELESLGEDIRRFLIENLSVTGGHIGPN
                     LGVVELTIALHKIFDSPKDKFLWDVGHQSYVHKILTGRACKFDTLRKYKGLCGFPKRNE
                     SEHDVWETGHSSTSLSAAMGMAIARDLKKTDDYIIPIIGDGALTGGMALEALNHIGHEQ
                     KDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYHWVKDELEFLLKKVPSVGGRLASTA
                     ERVKDGLKYMFVSGMFFEELGFTYLGPVDGHNYEELFDNLRYAKKTKGPILVHVLTKKG
                     KGYLPAESDKIGTWHGTGPYKIESGDFIKPKDTPPAWSKVISDTVQKVAREDDRVVAIT
                     PAMPVGSKLEAFQKEFPERMYDVGIAEQHATTVAAGLATQDMKPFLAIYSTFLQRAYDQ
                     VVHDVCRQNLNVFFGIDRAGLVGADGETHQGVFDIAFMRHIPNMVMMMPKDENEGQHLV
                     YTALQYNDGPIAIRYPRGNGLGVPMDKELKTIPIGTWEVLKEGHDATILTFGPSIEMAM
                     EAREKMAKNGVSVKIVNARFIKPLDHNMLHELFKENKPIMTIEEAVLEGGFGSAVLEFA
                     SDHGYDSSLIDRMGIPDYFVEHGSVDRLLEEIEFTTEHVVTRLQKRVNVKKTKGLEAR"
     misc_feature    11112..11125
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.73"
                     /tool="antismash"
     gene            12984..13808
                     /locus_tag="HPB58_RS04710"
                     /old_locus_tag="HPB58_04710"
     CDS             12984..13808
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391547.1"
                     /locus_tag="HPB58_RS04710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04710"
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_243517763.1"
                     /transl_table=11
                     /translation="MTKKERVDVLLVERGLVETREKAKRTVMAGLVYTNEQRLDKPGEK
                     ISVDTPLTVKGKVMPYVSRGGFKLEKALKEFDLTVKDKVMLDIGASTGGFTDCALQNGA
                     QLSYALDVGYNQLAWKMRQDERVVVMERTNFRYVTPDQLQFGMPQFASIDVSFISLKLI
                     FPVLKTLLVPNSDVVALVKPQFEAGREQVGKKGIVRDRAVHEDVLQEICTFVLHEGYDI
                     ASLTYSPITGGDGNIEFLLHLKWSGEKEVGETFSETTIEQAVTEAHAALKKG"
     misc_feature    complement(13947..13958)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.77"
                     /tool="antismash"
     gene            14007..14456
                     /gene="argR"
                     /locus_tag="HPB58_RS04715"
                     /old_locus_tag="HPB58_04715"
     CDS             14007..14456
                     /codon_start=1
                     /gene="argR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015594883.1"
                     /locus_tag="HPB58_RS04715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04715"
                     /product="transcriptional regulator ArgR"
                     /protein_id="WP_019391548.1"
                     /transl_table=11
                     /translation="MNKGQRHIKIREVIANNDIETQDDLVDILKSLGFNVTQATVSRDI
                     KELHLVKVPMLDGRYKYSLPADQRFNPLQKLKRALTDAFIKIDAAENLLVMKMLPGNAN
                     VVGALIDHLDWEEILGTICGDDTCLIICRTSEEAKTISNRFLEML"
     gene            14471..16180
                     /gene="recN"
                     /locus_tag="HPB58_RS04720"
                     /old_locus_tag="HPB58_04720"
     CDS             14471..16180
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391549.1"
                     /locus_tag="HPB58_RS04720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04720"
                     /product="DNA repair protein RecN"
                     /protein_id="WP_243517765.1"
                     /transl_table=11
                     /translation="MLAELSIKNFAIIESLSLSFEKGLTVLTGETGAGKSIIIDAIHLL
                     VGGRGSAEFVRHGTDRAEIEGLFLIEKSHPCFEKAESLGIEVEDEMVVLRRSITASGKS
                     ICRINGKLVTLAILREVGGTLVDIHGQHEHQDLMNGDRHLTLLDQYGGSTIEKALGVYG
                     SLYDEYISLKKQMEKLTENEQQRAHRLDLIQFQLNEIKTAELVPKEDENLFEEKIKISN
                     YEKIYSSLRDAYYALHGEQRGLDLVSVAMNNTGEIADLEDDYKEISETVSNCFYQLEDV
                     SYSIRQQLDALEFDPNRLDIIEARLNEINHLKRKYGQSVEEILAYADAIEEEIDTIQNR
                     DTHISKIEKQLEALMSELFKEAKNVSHIRQKLAEELTEKIHHELQALYMAKTVFKIQFA
                     KRGEEAPLSEKDVKFTKSGIDHVEFYISTNPGEPLKPLSKVASGGELSRIMLALKSIFS
                     HHQGVTSIIFDEVDTGVSGRVAQAIGEKIYQISTGSQVFCISHLPQVAAMADTHLFIAK
                     KSVNNRTQTSVTPLSSNEKIIEIGRMIAGVEVTDLTKEHAKELLELAHQLKK"
     gene            16344..17621
                     /gene="spoIVB"
                     /locus_tag="HPB58_RS04725"
                     /old_locus_tag="HPB58_04725"
     CDS             16344..17621
                     /EC_number="3.4.21.116"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="spoIVB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391550.1"
                     /locus_tag="HPB58_RS04725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04725"
                     /product="SpoIVB peptidase"
                     /protein_id="WP_243517767.1"
                     /transl_table=11
                     /translation="MDRYRKWIGTILLVSLIVIGFIPSVQQYVKIPTNITLFENQTLPI
                     QSAQQVSSNQPNVSVEPEKESSTWQVSGNNAGESKLVVQAGAFPAKEVDVKVLPDFKVY
                     PGGQSIGVKLNSKGVLVVGYHQVDTKDGKKSPGEIAGIQVGDMITEINGKNIEKMSDVT
                     PFIKQAGKSGDPLNITVTRDDQSIKTKLYPLKDKGDYAYRIGLYIRDSAAGIGTMTFFE
                     PNSKKYGALGHVISDMDTKKPIVVKDGQIMKSTVTSIEKGSDGAPGEKLARFSSERSVI
                     GDITRNSPFGIYGKLTEQVENNIVNKPLPIALSNQVKKGPAKILTVIEENKVEEFSVEI
                     VSTVDQKFPATKGMVVKVTDPKLLEKTGGIVQGMSGSPIIQDGRLVGAVTHVFVNDSTS
                     GYGVHIEWMLNEAGIDIYEHPRQKAS"
     misc_feature    complement(17824..17838)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.86"
                     /tool="antismash"
     gene            17867..18658
                     /gene="spo0A"
                     /locus_tag="HPB58_RS04730"
                     /old_locus_tag="HPB58_04730"
     CDS             17867..18658
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /GO_process="GO:0042173 - regulation of sporulation
                     resulting in formation of a cellular spore [Evidence IEA]"
                     /codon_start=1
                     /gene="spo0A"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_390302.1"
                     /locus_tag="HPB58_RS04730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04730"
                     /product="sporulation transcription factor Spo0A"
                     /protein_id="WP_019391551.1"
                     /transl_table=11
                     /translation="MKKIKVCLVDDNRELVSLLEDYLSTQEDIEVVGAAYNGQECLSLV
                     KEQKPDVLLLDIIMPHLDGIAVLTKLREMELEKAPNVIMLTAFGQEDVTKKAVDLGAAY
                     FILKPFDMENLVNNIRQVSGKAPTFTTRPQNSAIKVQRENKSNNLDANITSIIHEIGVP
                     AHIKGYMYLREAIAMVYRDIELLGSITKVLYPDIAKKYNTTASRVERAIRHAIEVAWSR
                     GNIESISSLFGYTVSMSKAKPTNSEFIAMVADKLRLEHKAS"
     gene            complement(18721..19038)
                     /locus_tag="HPB58_RS04735"
                     /old_locus_tag="HPB58_04735"
     CDS             complement(18721..19038)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010284710.1"
                     /locus_tag="HPB58_RS04735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04735"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_019391552.1"
                     /transl_table=11
                     /translation="MDRSLICPRFEKAMSILSQRWTGLVIYQLLTGPQRFCHIESSIGI
                     SGRVLSERLKDLEHEGIVKREVFPETPVRIEYSLTEKGAALEPLMNEIEKWSQNWLEAQ
                     N"
     gene            19188..19574
                     /locus_tag="HPB58_RS04740"
                     /old_locus_tag="HPB58_04740"
     CDS             19188..19574
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019637932.1"
                     /locus_tag="HPB58_RS04740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04740"
                     /product="DoxX family protein"
                     /protein_id="WP_019391553.1"
                     /transl_table=11
                     /translation="MTGYRVGSALLRVFLGITFFIHGLQKFQGGIENTVAFFESVGFPG
                     FSAYVVATIELVGGILMVLGVGTRIIAALFFFVLAGAILKVKLSAGFVGGYEVDLALLV
                     MAVHLAIVKNTAYSLENLWAKKEK"
     gene            19577..20419
                     /locus_tag="HPB58_RS04745"
                     /old_locus_tag="HPB58_04745"
     CDS             19577..20419
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391554.1"
                     /locus_tag="HPB58_RS04745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HPB58_04745"
                     /product="VOC family protein"
                     /protein_id="WP_243517769.1"
                     /transl_table=11
                     /translation="MKFQRYPIQHVELKVENLERSLSFYKKVIGFSVLKKTEKEAFLTA
                     DGETSLLSLKELEHYSPKQGKTTGLYHFAILLPERMYLASILKHFLKQGIELGASDHLV
                     SEALYLSDPDGNGIEVYADRDSSTWKWQNNEVVMDTKPLDGHNLLNELPKDEEWKGLPH
                     KTLIGHIHLHVRSLEEAEKFYKEGLGLDIVTNYGGHALFLSFHRYHHHIGVNVWAGKDA
                     KNPQPEHVGLKSFALFYDTKEQRDKAIERLISLGFHVKVQDDVFTVEDESGNKIKLVF"
     misc_feature    20771..20780
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
ORIGIN
        1 aaggccttca ttaaaagcgc taatagacgc ttgcattatc gaccgttttg tacttctttc
       61 aaatcgaaat ggacctggca ctgtggaagg ggtttttcag caggaagtaa aacgaaagaa
      121 agatggaata gaaggtgtaa gaaaatgaaa ctttttgggg ctttgtttat tttagttgcg
      181 acaacatggt ttggatttga tcttgcaaaa cagctcaatg caagaccaaa acagcttcgc
      241 cagcttaaaa gtgctctaag atcacttgag gcagaaatta tgtatagtca tcgtcctcta
      301 ccacagattg cccgtttatt aacagaacaa gtaccaaaac caatcgcttc cttttttgat
      361 tcttttgcaa catatttaga aaaaggtcaa aaaagtgctg gagaggcttg gctgcttagt
      421 atagaagaaa attggcgtct aactgcttta aagcaggggg agaaagaagc tttaaaacaa
      481 tttggacaga cgcttggaca gcatgatcgg tattcacagc aaaagcatat tgtgttaacg
      541 cttaaccatt tagagcggga ggaagcagac gctgttgaca ggcaaacgcg ctacgagaag
      601 atggtgaaaa gcctagggtt cctaacaggg ttattgttag tcattttatt actgtagctg
      661 taggaggatg aaacaaaatg ggggtagaca tcaataccat ttttcaaatt gccggagtag
      721 gcattatcgt tgctttttta gtaaccgttc tagaacaaat gggcaaaaaa gattttgcaa
      781 actgggttac gctcattggt tttatttata ttttgtttat ggtcgcgtca attgtacaag
      841 acttgtttca aaaaattaaa tctgtattcc tttttcaagg ctaaaggagg tgatgggaga
      901 ttgaaatgat ccaaattgtt ggccttggtt taattgccac gtttttaacg attattttaa
      961 aagaacaaaa atcctccatc gcttttcttc ttgttgtatt tgttggctgc gttattttct
     1021 tgtttctcgt tgataaaatc agcgaaatta ttggaatggt tgaagtcctt tcgcgtcaag
     1081 ccggggtcaa tgttatatat gtagaaacta ttttaaagat tattgggatt gcttatattg
     1141 ctgaattcgg cgctcaaatt acgaaagatg ctggacaagg ttccattgct tcaaaaatcg
     1201 agttaggagg gaaaatcctc attttatcaa tggcaatacc aattttaaca gtagtgattg
     1261 aaaccattat ttcaatgttg ccaacaacct aatgaatgag gattgaggtg cgcacatgaa
     1321 aaagaaaaaa agcttatttt gtttagtgtt gctgcttttt cttttttttc tacctgacag
     1381 tgtacaagct tttccaaatg ctgatgaaat ggtagatgaa caagtggatc agcttggcat
     1441 tgatgagata aaagggtttt ggaataatat catgacagag tatggtggtt ttttgccgga
     1501 aagtcagaaa ggaagtcttg tcgagttttt gaaaggagac aaagaacttt cgttagagga
     1561 gtggttgaaa gggcttatga agttctttct tcatgaaatt attgcaaatg gaaaactcct
     1621 cggtacgctc attatgctca caatcttttg cgtattcctc cagaatcttc agaatgcatt
     1681 tgagaaaaca accgttagta aagtagctta tgcacttgtt tatcttgtgc ttattgtcat
     1741 tgctttaaat agcttccaca ttgctatctc atatgcaacg gaagctatac agacgatgat
     1801 tcattttatt atcgcgctta ttcctcttct tctagctctt atggcttctt cgggaggcgt
     1861 gatgtcagcc gctttttttc atccagttat tatttttctt atgaacacaa gcggattgct
     1921 tattcagtat gttgtaatgc cgcttttatt tctttctgcc ctgttaagca ttgtaagtac
     1981 aatttcagaa caatacaaag tgacacagct tgctcagctt atgagaaatg tgagtattgg
     2041 agttcttggt gggtttctca ctattttttt aggcgttatt tctgttcagg ggacaagctc
     2101 ggctgtagca gatgggatca ctgtgagaac cgcaaaattt attacaggaa actttgttcc
     2161 tgttgtagga cggatgttta cagatgcaac agatacagta ttaagtgcct ctcttctatt
     2221 gaaaaatacg gtgggccttg ttggagtagc gattttactt tttattacag cttttcctgc
     2281 tcttaaactc ctttcaattg cgattattta caagcttgct gcagctctga tccagcctgt
     2341 tggaggagga ccaatcatct cctgtttgag catcattagc agaagcgtta tttatatttt
     2401 tgctgctctt gctgttgttt ctttaatgtt tttcttatgt attacgcttg ttattactgc
     2461 aagtaatatt acgatgatgg tcagataagg agggtgttga tgggagcgtt aacagaatgg
     2521 gttacaaata ttattctgtt tatcttgctt gctaccatta ttgatctgtt gttaccaagc
     2581 tcatctatgc agaagtacgc aaagatggtt attggtctac ttcttatgct tattattttg
     2641 acacctgttt tcagcatatt caaagtgaac gttgataaac tgtttaccgc cattaactct
     2701 tcttctatct ctcaagaaaa ctcttcaaaa aatttgctag atttaaagaa aaaagaaata
     2761 caagcgtcac aagatgcata tattttagaa cagatggctg tccaactaga agagggagta
     2821 aaagaggagt tggtgaagga atatggagta gaagtttcag gcgtagaaat tcatatgaaa
     2881 gacgagaaag gtgaaaaaag ttttgaaaat attagttcca tctctctgtc tgttcagcca
     2941 aaggagaata agcatacagc atcagtctca gaagttgaag ttgtttccat taatacgtcg
     3001 gaacctatta aaaaagagaa aacagaaaac gacgagaagc taaagaaagt acaaagtttt
     3061 ctttctaaaa aatgggatat ggataaaaaa caaattatag tcacaatggg aggaggagaa
     3121 gcagatgagc gataaggaga gcaacaagaa aaagaacttc ttagcgagac tatcttcttc
     3181 agatccacct aagaaaaacc gcaagcttgc atatgtgatt ttacttttgg ccgctggggt
     3241 ttttgtcatg ctctatggga attttcaaag ctcaacaaca aaaccagacg ccgttgaaac
     3301 gaaaggctca ggagatagcc aacaagaaac agaggaagta gaaacgtttg gaagtggaaa
     3361 agaaaagcag gctagaacaa tttcagacta tgaaaaaaaa tacgaagcag aacttacaga
     3421 tgtgctagaa agtatgatgg gcattgataa tgtgcaagta tttgtaaatg ttgatgctac
     3481 agaagagaaa gtttatgagc ataacacagt aaaccaaagt caaacaacag aagaaaatga
     3541 ccgtgaaggc ggtacaagga atattgaaga taactcagtg gatcaacagc tcgttattgt
     3601 tcgtaacggt gataaggaac agcccgttgt tgtaaaaaca ttaaaacctg atattagggg
     3661 cgttcttgtc gttgcgaagg gagctgataa tataaaagtg aaaaagtcgg ttgtggacgc
     3721 agttacgaga gtgctcgatg ttccaagtca tcgcgtggca gtcacgccta aaaagacgaa
     3781 gggggattaa attatatgtt gctgaaaaaa caaaccgttt ggttattaac aatgcttagc
     3841 ttagttgttg ttttatctgt ttattatatt acgtctccaa gcccacagag tgataacgtc
     3901 gcttttacag ataaagaaga aagtaaagaa aaagaaagcg caaagcaaac ggataaagaa
     3961 acagagcaaa agggagcttc aacaacagag aaaaacggtg aaacagttgt ttcaactgtg
     4021 gaaaatgaag accaattttt ggcgatgcgt atgcaaatta cagacgagag aagtaaagaa
     4081 attgagaaac ttgaggacgt tgtcgcatca aatgaggctt cagtagaaga gaaaagtgaa
     4141 gcaaaggaca aagtagaaga actttcaaaa cttaatgaaa aagagcaaac aattgaaaca
     4201 ttaatcaaag aaaaagggta tgatgatgcc cttgtacgcg ctgaagaaaa tggtgtacgt
     4261 atcgttgtaa aatcaaaaga agatagcaaa aaacaagcaa atgaaattat gaatatcgtg
     4321 acgcaagaaa ttggagctaa gaaagtagcg gtagaatttg agcctattaa ataatgaaat
     4381 aaaaaaaggc gacttctgtc gccttttttt tatttgaact tattttgcat ccgaagcaag
     4441 actgaaatat aatagttaat gataacacta ggtaataact agtacattgt caaagaaaag
     4501 aagtttactt aaaatagaaa aggacggttg tccaaagcat acggctgttg aaattttaag
     4561 ggcagttagc gtatgatgtt aagtattcac tagtcgatga aatggagtgt aaaagagatg
     4621 ttaaaaattc aagagattcg cgaaattatt cgccttgttg atcagtcatc tatcgaagaa
     4681 tttatgtacg agcatgaagg atcaaaaatt aagttgaaaa agaagggtgc tcttgcagca
     4741 caacagaaag tagttattca ggaacagcct gttcaacaaa taccggctca gccatcagtg
     4801 cagcctgttg tgcaacaaaa tgaaccacaa caaccggtac atacagaaga gaaaaaagaa
     4861 gagagcaacc ttcataaaat tacatcacca atggttggaa ctttttataa ttcttcttca
     4921 ccagaagcag gtccatatgt tcaaacggga accaaagtta aacaagatag cgtagtttgt
     4981 attgtggaag cgatgaaact attcaacgaa attgaggctg aggtaacagg agaaatcgtt
     5041 gaaatacttg ttgaaaatgg tcagcttgta gaatatggtc aaccactttt cttagttaaa
     5101 ccagaataaa gggagatcaa ttatgataaa aaaattgctt attgcgaacc gcggagaaat
     5161 cgccgtaaga attatccgcg catgtaaaga attaaatgtc gagtctgttg cgatttattc
     5221 agaagcagat aaagagtcac tgcacgttcg tcttgctgat gaagcatatt gtgtaggtcc
     5281 taccgcttca aaagacagct acttaaattt cacaaatatc atgggtgttg caatgcttac
     5341 aggatgtgat gcgattcacc ctggttacgg atttttatct gagaacgctg attttgctga
     5401 gctttgccgt gagtgtaacg taacgtttgt tggaccaaca tcagagtcca tttcaaaaat
     5461 gggtacaaaa gatgtggcaa gagaaacaat gcgtgaagca ggtgtaccga ttgtacctgg
     5521 atctcaagga attattgaaa gtgtggaaga tgcagttaca attgcagagg aaattgggta
     5581 tcctgtaatt attaaagcaa cagcaggcgg aggcggaaaa ggaatccgtg ttgcgcgtga
     5641 cgaatcttct ttaagaaaag gtgtagaaat tacacagcaa gaagccgcaa cagcatttgg
     5701 aaacccaggg gtttatttag aaaagtatat cgaagatttc cgccacgttg aaatccaagt
     5761 gttggcagat gaatttggta ataccattca ccttggtgaa cgtgattgca gtattcagcg
     5821 ccgtcttcaa aaattagttg aagaaacgcc ttctccagcc cttgatggag aaatgcgtgc
     5881 gaaaatggga gaagctgctg ttaaagcagc acaagctgtt caatatagag gggctggaac
     5941 agtggaattt atctatgact accgtgaaag aaagttctat ttcatggaaa tgaacacgcg
     6001 tatccaagtt gaacatccag tgacagaaat ggtaacaggt attgacttaa ttaaagagca
     6061 aatcaaagtg gcaaaccatg agaagctctc gtatacgcaa gaagacgtta cattttctgg
     6121 atgggcaatt gaatgccgta tcaatgctga aaacccagcg aaaaacttca tgccatctcc
     6181 aggggaaatc aatatgtatc ttcctccagg cggttttggc gttcgtgttg attctgcggt
     6241 atactcaggg tataaaattc cgcctttcta cgattcaatg attgctaaat taattgttca
     6301 tgctccaacg cgcgaagaag ctgttgcaag aatgagaaga gctctaagcg agtttgttat
     6361 tgaaggcgta gatacaacaa ttccgtttca tttaaattta tttcaacatg agaaattcat
     6421 tgaaggggaa tttaatacga agtttctaga agaacatgag gtaatgaaaa gtaagtaatt
     6481 ctcaaggagg aatagcctat gaacgaaaat catgtgttag atatgggaga aaatgaaaat
     6541 gcgttaggga aagtagaaat cgctcctgaa gtgattgaag ttatcgcagg tattgccgca
     6601 tctgaagtag caggcgttgg ccaaatgcgc ggaaactttg cgtctggcgt tgttgagaag
     6661 cttgggaaaa agaatcacgg caaaggcgtc aaagtagagc ttagtgaaga aggcattaaa
     6721 attgatgtgt tctgctctat gaactatggc gtttctattc caacggttgc aagtcaagtt
     6781 caagataaca ttcgagaagc gttgaaaaat atgacagcac tcgaattagc agaagttaac
     6841 gttcatatcg tgggcgtaat ctttgaatct cctcaaaagg aagaagagat tgattctatc
     6901 taatgaaggg gctgctctta caataagagc agcttttttg cgagtttctt tcttgttgtt
     6961 tccaattctt atttctgtga agattcggaa aataacaata cgtggatacg ttatgtactc
     7021 acggtaggaa actatgctat tatcaggata tgataattgg ataagttaaa aaaggagtat
     7081 acctatttat gaaaagacgt acagcaaggg aaaaagcgct tcaagctctt tttcaatgtg
     7141 agattggcca aaatagccct gaagaagcta ttgacaatgt agtagaagag gaagcggttg
     7201 atgcgttttt acgtcagctt gttcttggtg tgtcagaaaa caaagaagag attgacagct
     7261 tgattagcgc aaaccttgaa aaatggacgc tagatcgtct agcgaacgtt gaccgtatta
     7321 ttttaagact tgcggtttat gaaatgaaat atgaagaaga cattccccaa aatgtaagca
     7381 ttaatgaagc catcgaactt gcaaagacgt ttggcgatga tcaatcaggt cgttttatca
     7441 atggcgtatt atctaaaatc tcagcatcaa atagttaaaa atcttttata aaagatttaa
     7501 aataaagtta taaaacaaca tacagagatg acagagaagg agagaatgat caatgagtgc
     7561 acaattaatt aatggtaaag aactagcaag tgagaagcga gaaagtatga aaaaagaagt
     7621 tgaaatgcta aaggagcaag gagttaaacc aggcttagct gttatattag ttggacaaga
     7681 ccctgcttca gaaacatatg tacgcagtaa acatcgcgct tgtgaaaata caggtattca
     7741 ttcggtttca atcaaacttc cagatacagt atcagaagaa gaactacttg gtcatattga
     7801 caagttaaat gaagatgatg caattgatgg aattttagtt cagcttccac ttccaaaaca
     7861 tattaatgaa gatgctgtca tcgagcgcat ttctcctaaa aaggacgttg atggttttca
     7921 tccaatcagc gttggtaaaa tgatgattgg tcaagaaaca ttcttgccat gtactccaca
     7981 tggcgtatta gaaatggtta gaaaaacagg tattgaagta tctggaaaac acgttgttgt
     8041 gattgggcgc agcaatattg ttggtaaacc tgttggacaa ttattcttaa atgaaaatgc
     8101 aacggtaaca tactgtcact ctagaacaca aaacatgcaa aagcacacaa gagatgcaga
     8161 tatcctaatt gttgcggttg gaattccaaa ctttgttaaa gctcaagatg taaaagaagg
     8221 agcggttgtg attgatgttg gaattaaccg cgtagacgga aagctttgtg gagacgtaga
     8281 ttttgaagaa gtaaaagaag ttgctggtgc tattacacct gttccaggtg gagtaggtcc
     8341 gatgacaatt acaatgcttt tagaaaatac aatccagtca gcaaaagctc gcgttcgttc
     8401 ttaataacaa gggggaagtg tcatgagcga attaaagcct ttaacaatta cggctttaac
     8461 gaaatatatc aaacgaaaat ttgacgttga tccccatttg caagatgttt ggctgaaagg
     8521 ggaaatctca aattttaaac agcatagcag agggcatatg tattttacct taaaagacga
     8581 gcatgcccgc atgtctgctg tgatgttttc aagtcaaaat aaaaatttgc cttttacccc
     8641 tgaaaacggt atgaaagttc ttgcaagggg agaagtttca gtttacgaag gaagcggcaa
     8701 ttatcagctt tatattcgcg acatgcagcc tgacggagta ggaagtcttc atcttgctta
     8761 tgagcagctg aagaataaat tagagggaga agggcttttt gatcctagga ttaaaaagcc
     8821 tctccctctt tatcctaacc tcgttggagt tgtgacctct ccaacaggag cagctgtaag
     8881 ggatattatg acaacgatta aacggagata tcctgttgct caaattattt taattccagc
     8941 tcttgtacaa ggtgatcgcg ctcctgcttc aattgtaagt ggaattaaaa aggcgaagga
     9001 tataaacgcg gatgtgctga ttatcggacg tggcggtggt tctattgaag aactttgggg
     9061 atttaacgat gaaaaagttg cccgagctat atatgagtca actcttccta ttatttcagc
     9121 tgtaggtcat gaaacagatt tcacgatcgc tgattttgta gctgacatgc gtgctccaac
     9181 tcctactgca gcagctgaac tagctgtgcc taatttaacg gaggtacttg aacgaattag
     9241 ccagcggaaa atccgcttaa caagagcaat ttcgtctcat attaccgcaa aaaagacgcg
     9301 tttagaacgt acagagaagt cgtatgcttt tcgatatcca acaaagctgc tagaacaaaa
     9361 ggagcagcaa ttggatcttt tgcttgatcg tttacataag gaaagtaagc gtattgctat
     9421 gagaaaggaa gaaaagttct cttacataaa gcgtcgcctt cttacacatc atccatatgc
     9481 aaggttaaaa gaagctgaca gagaacgaga acgtttaaca cgcttgttac aaaaagatat
     9541 aacaacagtg ttgaatgcta aaaagatgtt gttgtcttct cagatggcaa agctaaatgc
     9601 gctcagtccg ttaaagatta tggagcgtgg atatagtctt gtatacaatg aagaagaaaa
     9661 gcttgtgaaa agcacaaaag gtgtagcaaa aggtgaaacg gtaacgctac gcttgaaaga
     9721 tgggtccatt gattgtcttg tagaagacat aaggagtggt gagaatgagt gaagaaaaag
     9781 aatatacatt tgaagaagcg atggaagaac ttgaaaaaat tgttgataaa cttgaagaag
     9841 gtgacgttcc tttagaagaa gctattgacc gatttcaaga aggaatgaaa ctttcaaaat
     9901 tttgtcatga tcggcttcaa aaaattgaaa cacaaatgga gcaaatcttg caagaagatg
     9961 gaaatcttgc tcctttctct gttggagagg aaggtgacaa atgatcgcgc ttgagagcta
    10021 tttaaaagaa tataaaaagt tagtcgaaga gcttctccca acgcaaatcg aagcgctgca
    10081 gatgccaagt ttgctgaaag aatcaatgtt atactctcta acagcaggcg gaaagcgcat
    10141 tcgtccaatt cttcttttag caacgcttga agcattcggg aaagataaat cccttggtta
    10201 tgaagcggca tgtgctgttg aaatgattca cacatactca ttagttcatg atgacttgcc
    10261 aagcatggat gatgatgatt taagaagagg aaagccaaca aaccataaag tgttcggaga
    10321 agcagccgct attttagctg gcgatgcttt gctaacctat agctttcaaa tcgtaacaaa
    10381 agctaacctt tctccagaaa ttaagttgct tgtgattgaa gagttagcac gtgcagcagg
    10441 tgctgaagga atggttgggg ggcagatggc tgatattgaa ggcgaagaga aaaagctttc
    10501 gttaaaagag ttagaataca tccatgaaca taagacagga aaactccttt cttttgggat
    10561 tattgctgga gcaattattg caggagcatc ggaagatcag cttagtcatt tgaaacattt
    10621 cagctatcat cttggtttag cttttcaaat tcaagatgac atcttagata ttgaaggaaa
    10681 tgaacagctt cttggtaaac ctgttggaag tgatacaggt aatgataaag caacatatcc
    10741 agctctttta ggtatggaaa atgcaaaaga gaaattaaag tatcatatgg atcaagccat
    10801 tatggagctt gaaaaagctg aaattcaaga tagcatgtta aaagagcttt cttattacat
    10861 cgcatggcgt cagcaataaa agaatatcaa aagctaaaga ttgagcttga gatgttttta
    10921 tgctacaata atgtcacaat tatgctatgg agtgtttagt tttttttgaa aattagaaag
    10981 tgattctttc ttgccgttat cacgtttgtg ttagcggctc ttttttcaag gaaggctact
    11041 aaagtagtgt ggctaactaa gtacgaaagt gagtgatccg atttggatct tacgtcaata
    11101 aaaaatccgg catttttaaa gaaaatgtct actagtgaat tagagtcact tggagaagat
    11161 attcgacgct ttttgatcga gaatctgtcc gttacagggg gccacattgg tccgaatctt
    11221 ggggttgttg aattaacaat tgcgcttcat aaaatttttg atagcccaaa agacaagttt
    11281 ttatgggatg ttggacatca atcatatgtc cataaaattt taactggccg tgcctgtaaa
    11341 ttcgatacat tacgtaaata caaaggatta tgtggatttc cgaaacgaaa tgaaagcgaa
    11401 catgatgttt gggaaacagg tcacagttca acgtctttat cagcggcaat gggaatggct
    11461 attgcaagag atctgaagaa aacagatgat tatatcattc cgattattgg tgatggagct
    11521 ttaacaggtg gaatggcttt ggaagcttta aaccacattg gacatgagca aaaagacatg
    11581 atcgttattt taaatgataa tgaaatgtct attgccccaa acgttggtgc actgcataat
    11641 gtgctaggtc gtttgcgcac agctggcaaa tatcattggg ttaaagatga gcttgagttt
    11701 ttacttaaaa aagttccatc tgttggagga cgtttagctt caacagctga acgtgtaaaa
    11761 gatggtctaa agtatatgtt tgtatcgggc atgttctttg aagaacttgg gttcacatat
    11821 cttggtcctg ttgatgggca caactatgag gaactgttcg ataatcttcg ctatgctaaa
    11881 aaaacaaaag gtcctatcct tgtgcatgtt ttaacgaaaa aaggaaaagg atacttgcct
    11941 gctgaaagcg ataaaattgg aacatggcat ggtacaggcc cttataagat tgaatcaggt
    12001 gacttcatta aaccaaaaga cacgcctcca gcgtggagta aagttatcag cgatactgtt
    12061 caaaaagtag cacgtgaaga tgacagagtt gttgcaataa caccagctat gcctgttggt
    12121 tcaaagcttg aagctttcca aaaagaattt cctgagcgca tgtatgatgt aggaattgct
    12181 gaacaacatg ccacaactgt agcagcagga cttgctacac aagacatgaa accgttttta
    12241 gctatctatt caacattttt acagcgtgca tatgaccaag ttgtgcatga cgtatgtcgt
    12301 caaaacttga acgttttctt tggtattgat cgagcaggtc ttgtgggagc tgatggtgaa
    12361 acacatcaag gcgtatttga cattgccttt atgcgccata ttccaaacat ggttatgatg
    12421 atgccgaaag atgaaaatga gggccaacat ttagtgtaca cagctcttca atataacgat
    12481 ggtccaattg caatacgtta tccacgtgga aatggacttg gtgttccaat ggataaagaa
    12541 ctaaaaacaa ttccaattgg aacgtgggaa gtgttaaaag aagggcatga tgccacaatc
    12601 ttaacatttg gtccttcaat tgagatggcc atggaagctc gtgaaaagat ggcgaagaac
    12661 ggagtatctg ttaagattgt aaacgctcgt tttattaagc cgcttgatca taatatgctc
    12721 catgagcttt ttaaagaaaa taaaccgatc atgactattg aagaagctgt tttagaaggt
    12781 ggctttggaa gtgctgtatt agagtttgct tcagatcatg ggtatgatag ttcacttatt
    12841 gatcgcatgg gaattccaga ctactttgta gagcatggaa gcgttgatcg ccttctagaa
    12901 gaaattgagt ttacaacaga acatgttgta actcgtttac aaaagcgtgt gaacgtaaaa
    12961 aagactaaag gacttgaagc aaggtgacca aaaaagaacg tgtagatgtg ttattggtgg
    13021 agcgtggctt agtggaaaca cgtgaaaaag ctaaacgcac tgtcatggca ggtctcgtat
    13081 atacaaatga acaaagatta gataaacctg gagaaaaaat ttcagttgat acacctctta
    13141 ctgtaaaagg aaaagtaatg ccttatgtaa gcagaggagg atttaaactc gaaaaggcgc
    13201 ttaaggaatt tgatcttact gtaaaagata aagttatgtt agatatcgga gcatcgacag
    13261 gtggctttac agattgcgct cttcaaaatg gagcacagct ttcttatgcg cttgatgtgg
    13321 gatataatca gcttgcatgg aaaatgcgtc aagatgagcg tgtggttgtg atggaaagaa
    13381 caaatttccg ctatgtaaca ccagatcagc tacagtttgg aatgccgcaa tttgcttcta
    13441 ttgacgtttc ttttatttct ttaaaattaa tttttccggt tcttaaaaca ttacttgttc
    13501 caaatagtga tgttgttgct cttgtgaaac cacagtttga agcaggacgc gagcaagttg
    13561 ggaaaaaagg aattgtcaga gatcgagctg tacatgaaga tgtactccaa gaaatttgta
    13621 catttgttct tcatgaagga tatgatattg cttctttgac gtattctcca attacagggg
    13681 gagatggaaa tattgaattt cttcttcatc taaagtggag tggagaaaaa gaagttggcg
    13741 aaactttttc tgaaacaaca atagaacaag ccgtaacaga agcgcatgcg gctttaaaaa
    13801 aagggtaata aattaagcgg tgctttttat agcgccgctt aaagtttgtc atggcttgct
    13861 ttagaagttg tctaagccgc gataattagc taacatagta ttacatacat tgttttgtga
    13921 aaaagggaga gcttataaaa aaacaagaaa actttttctt atacatagct ataattcaaa
    13981 ttcaaagatt atgtgaggtg taaatgatga ataaaggaca gcgacatatt aaaattagag
    14041 aagttattgc aaataacgat attgaaacac aggatgattt agtcgatatt ttaaaaagct
    14101 taggttttaa tgttacacaa gcaacagttt cccgtgatat taaagaactt catcttgtaa
    14161 aagtgccaat gcttgatggg cgctacaaat atagcttacc agctgaccag cgttttaatc
    14221 ctcttcaaaa attaaagcgt gctcttacag atgcatttat aaaaattgat gcggctgaga
    14281 atttgcttgt tatgaaaatg ttgccaggta atgcaaacgt agttggagct cttattgatc
    14341 acttagattg ggaagaaatt ttaggaacaa tttgtggaga cgatacgtgt ttaattattt
    14401 gtagaacgtc tgaggaagcc aaaacgattt caaatcgctt tttagaaatg ctgtagggat
    14461 gtgagtagga gtgttagccg aactatcgat taaaaacttt gcaattatcg aaagcctatc
    14521 tctttcattt gaaaaaggat taactgtttt aacaggggag acaggggctg gaaagtctat
    14581 tattattgat gcgattcatt tacttgttgg aggacgaggc tctgctgaat ttgttcgaca
    14641 cggtacggat cgagcagaaa tagaagggct gtttttaatt gaaaaaagcc atccttgctt
    14701 tgaaaaagca gagtcgcttg gaattgaagt ggaggatgag atggttgtgc taaggcgctc
    14761 gattacagcg agcggaaaaa gcatttgtcg cattaacgga aagcttgtga cacttgcaat
    14821 tttacgtgaa gtcggtggaa cgcttgttga tattcacggg cagcatgaac atcaagacct
    14881 tatgaatggt gatcgacact taacattgct tgatcaatat ggtggttcga ctattgaaaa
    14941 agcgctaggg gtatacggtt cgctttatga tgaatacata agtctgaaaa aacaaatgga
    15001 aaagctaacg gaaaatgagc agcaaagggc ccataggcta gacttaattc agtttcagct
    15061 caatgaaatc aaaacagctg aacttgtacc aaaagaagat gagaatcttt ttgaagagaa
    15121 aattaaaatt tcgaactatg aaaagattta tagctcgctc agagatgctt attatgcttt
    15181 gcacggggaa caaagagggc ttgatttagt atctgttgca atgaacaaca caggtgagat
    15241 tgctgaccta gaagatgact ataaagaaat ttcagaaaca gtgtcaaact gtttttatca
    15301 acttgaagac gtttcataca gcattcgcca acagcttgat gctttagaat ttgatccaaa
    15361 tcggcttgat attattgaag ctagattaaa tgagatcaat cacttaaaga gaaagtacgg
    15421 acaatcggtg gaagagattt tagcatatgc tgatgctatt gaagaagaaa ttgatacgat
    15481 tcaaaataga gatacgcaca tttctaaaat tgaaaaacag cttgaggcat tgatgagtga
    15541 actttttaaa gaagcgaaaa atgtttctca tattcgacaa aagctggctg aagagttaac
    15601 agaaaagatt catcatgagc ttcaagctct ttatatggct aaaaccgtat ttaaaattca
    15661 gtttgctaaa cgtggagaag aagcgcccct tagtgaaaaa gatgtaaaat ttacgaaaag
    15721 cggaattgat catgtggagt tttacatctc aacaaaccct ggtgaaccgt tgaagccttt
    15781 atcaaaagta gcgtcaggag gagagctttc tagaattatg ctcgcgctta aaagtatttt
    15841 ctcacatcat caaggtgtaa catctattat ttttgatgaa gtagacacag gagtaagtgg
    15901 gcgagttgct caagctattg gagagaagat ttaccaaatc tcaacaggtt cacaagtttt
    15961 ctgtatttct catctgccac aggttgcagc gatggctgat acgcacttat ttattgctaa
    16021 aaagtctgtg aataatagaa cgcaaacaag cgttacaccg cttagttcta atgaaaaaat
    16081 tattgaaatt ggccgtatga tcgcaggagt tgaagtgaca gatttaacaa aagaacatgc
    16141 aaaagagctg cttgagcttg cacatcagct gaaaaagtag ggagacaaat tctccctact
    16201 ttttctcgtt tttcgtagtt ataattgtgc gcaaagaagg taacattaaa gacataagca
    16261 aaagcttcat tttacaatct caggtgctta tttattcaac gaagaagtgt gtgtggcagg
    16321 aagcgaggag agtgaaatgt tcaatggata gatatagaaa atggatagga acaattctcc
    16381 ttgtttcgct catcgtaata ggttttatac caagtgtgca gcaatatgta aaaatcccaa
    16441 caaacatcac cctttttgaa aatcaaacgt tgcccattca gtccgctcag caagtgtcat
    16501 caaatcagcc aaatgtttca gtagaacctg aaaaggaaag ttcaacatgg caagtcagtg
    16561 gtaataatgc tggagaaagc aaactcgttg tccaagcagg cgcttttcca gcaaaagaag
    16621 ttgatgtaaa agttcttcct gattttaaag tatatccagg aggacaatcg attggagtaa
    16681 aacttaactc taaaggtgtt cttgttgttg gatatcatca ggttgataca aaagacggaa
    16741 aaaaatctcc aggtgaaatt gcaggaatcc aagttggaga tatgattact gaaattaacg
    16801 ggaaaaacat cgagaaaatg agtgatgtaa ctccgtttat caaacaagca ggaaaaagtg
    16861 gggatccact taacatcaca gttactcgtg atgaccaaag tattaaaaca aaactttatc
    16921 cattgaagga taaaggagat tatgcttatc gaattggact atatattcgt gattcagcag
    16981 ctggtattgg tacgatgact ttttttgagc caaattcgaa aaaatatgga gctcttggtc
    17041 atgtgatttc ggatatggat acgaaaaagc cgattgttgt gaaagatgga cagattatga
    17101 agtcaacggt cacgtcgatt gaaaaaggaa gtgacggagc tcctggagag aagcttgctc
    17161 gtttttcttc ggaacgttct gtaattggtg acattacgcg caacagtccg tttggtattt
    17221 acgggaaatt aacggaacaa gtagaaaaca acattgtgaa caaacccctt cctattgcgc
    17281 tttcaaatca agtgaaaaag gggccagcca aaatcttaac cgtaattgaa gagaataaag
    17341 tagaagagtt tagtgtcgaa attgtaagta cagttgatca gaagtttcca gcaacaaaag
    17401 gaatggtagt taaagtaaca gatccaaaac ttctcgagaa aacgggagga attgtgcaag
    17461 gcatgagtgg aagccctatt attcaagatg gtcgcttagt tggtgctgta actcacgttt
    17521 ttgttaacga ttcaacatca gggtacgggg tccatattga atggatgcta aacgaagcag
    17581 gaatagacat ttatgaacat ccacgacaaa aggcgagcta attatagttc gtcttttttg
    17641 tcatttcttc ttttctaaac agaaactttt tgacctttgt catattgttt aaagtgctga
    17701 catttcttat caatataaca gtatttttgt taaaatggtg gaaggaatca ccttttatcc
    17761 aaaaaataaa aggaaatggt cttgcattgt cgaattgttc atttagaata agtttagaga
    17821 cctatcgaca cagtagatta ttatatggga tcgaggagga gttatattga aaaagattaa
    17881 ggtttgctta gttgatgata accgtgaact cgtgagctta ttagaagatt acctctcaac
    17941 acaagaagat attgaagttg taggggctgc ttataatggc caagagtgcc tttcgttagt
    18001 caaagagcaa aaacctgatg tgttgctatt agatattatt atgccccatt tagatgggat
    18061 agcggtatta acaaaattga gagagatgga gcttgaaaaa gcacctaatg tcatcatgtt
    18121 aactgcgttc ggacaagaag atgtaacaaa gaaagccgtt gacttaggtg ctgcatactt
    18181 catccttaaa ccgttcgata tggaaaatct cgtcaacaat atccgccaag tgagcggaaa
    18241 agcgccaact tttacaactc gcccacaaaa ttcagcaatt aaagtgcaac gagaaaataa
    18301 gagcaataac ttagatgcaa atattacgag cattatccat gaaattggcg tacctgctca
    18361 tattaaagga tatatgtact tacgagaagc tattgcaatg gtatatagag atattgagct
    18421 gctcggctct attacaaaag ttttatatcc agacattgct aaaaaatata acacaacagc
    18481 aagtcgcgtt gagcgtgcta ttcgtcatgc aattgaagtt gcatggagca gaggaaatat
    18541 tgaatcgatc tcttcacttt tcggttatac agtaagcatg agcaaagcaa aaccaacaaa
    18601 tagcgaattt atcgcaatgg tagcagataa attacgcctt gaacataaag caagttgaaa
    18661 gggttagacc tttttggcgc aaaaaagacc aatgattagt cattggtctt tttttgtaat
    18721 ttagttttgc gcttctaacc agttttgtga ccacttctca atttcattca taagcggttc
    18781 tagtgctgct cctttttccg ttaaggaata ttcaattctc acgggtgtct caggaaacac
    18841 ttcgcgtttt acaattcctt catgttcaag atcttttaag cgttcagaca gcacacgacc
    18901 gctaattcca atggatgatt caatatgaca aaagcgctgt ggacctgtta gaagttgata
    18961 aataactaat ccagtccatc tttgacttaa tatgctcata gctttttcga aacgtgggca
    19021 aattaatgat ctatccaaat gtatcactcc ctaccttcta ttataatcat taaaatgaat
    19081 aattaaatga ttttgactca gaaagttact tgacataaat taataacaaa aatataataa
    19141 cttacataaa gtaagttact aacaaacaga gaaaaggagc aagtataatg acaggatata
    19201 gagtaggttc agcactttta cgtgtgtttt taggaattac attttttatt catggacttc
    19261 aaaaatttca gggaggaatt gaaaatacgg ttgctttctt tgaaagtgtc ggttttccag
    19321 gattctctgc ttacgttgta gcaacaatcg aattagttgg tggaattctt atggttctag
    19381 gtgtgggaac ccgtattatt gcagctttgt tcttcttcgt tttagcagga gctattctaa
    19441 aagttaagct atcagcaggt tttgttggtg gatatgaagt tgacctagcg ttacttgtta
    19501 tggctgttca tctagcaatt gttaaaaaca cagcatattc acttgaaaat ttgtgggcaa
    19561 agaaggaaaa ataaagatga aatttcaacg ctatccaatt caacatgtgg aacttaaagt
    19621 tgaaaattta gaacgatccc tttctttcta taaaaaagtg attggatttt ctgtattaaa
    19681 aaaaacggag aaagaagctt ttctgacagc agatggtgaa acaagtttgc tttctttaaa
    19741 agagcttgaa cactatagtc caaagcaagg aaaaacaaca ggactttatc actttgctat
    19801 tttattacca gaacgcatgt acttagcttc aattctaaag cactttttga aacaaggcat
    19861 tgagcttggc gcatctgacc acctcgtaag tgaagcactt tatttatcag atccagatgg
    19921 aaacggaatt gaagtgtatg ctgatcgtga ttcatcaaca tggaagtggc aaaataatga
    19981 agttgttatg gatacaaaac cacttgatgg acacaatctt ttaaatgagc ttccaaagga
    20041 tgaagagtgg aaaggtctcc cgcataaaac tcttattgga catatccatc ttcatgttcg
    20101 tagtcttgaa gaagcggaga agttttataa agaaggttta ggtcttgata ttgtaacgaa
    20161 ttacggaggg catgcgcttt ttctttcttt tcatcgttat catcatcata ttggagttaa
    20221 cgtttgggca ggtaaggatg ctaaaaatcc acaacctgaa catgtaggtt taaaatcatt
    20281 tgctcttttt tacgatacga aagagcaaag agacaaagcg attgaaagat taatttctct
    20341 tgggttccat gtaaaagtac aagatgatgt atttacagtc gaagacgaga gtggaaataa
    20401 aataaaatta gttttctgat ataaggagga gaaacgatgg gatttttaca aaaagtgttc
    20461 ggaagtgcac aagaagaaac aaaaggaact aacttttatg aggctgtaga aagtcgacgt
    20521 tcaatttatg ggattagcaa tgagcaagtt atctcagatg aaagattgaa agaagttatt
    20581 gaacatgctg taaaacatac accatcttct tttaattcgc aaagtgcatc tgttgtcgta
    20641 ttaacagggg aaagccataa aaaactttgg gatattacaa cagaaacgct tcgtaaaatt
    20701 gtgccagaag atgcttttag cgaaacagaa aataaaatga atggctttaa aagcggttat
    20761 gggactgtgc tgttttttga aaatatggat gttgtccaat cacttcagga acagttccca
    20821 tcatatgcag aaaattttcc actctggtct ttacaatcaa gtggaatgtt gcaacacgt
//
