Select genomic region:
Overview
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1.7
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1.9
1.10
1.11
1.12
1.13
1.14
1.15

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP063142.1 (Priestia filamentosa)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | terpene-precursor | 896,440 | 917,318 |  |
Region 2 | lassopeptide | 1,353,472 | 1,377,325 | Medium | paeninodin | ribosomal:unmodified
Region 3 | NRP-metallophore,NRPS | 1,395,535 | 1,447,169 | High | bacillibactin/bacillibactin E/bacillibactin F | NRPS:Type I
Region 4 | RRE-containing | 1,870,903 | 1,892,012 |
Region 5 | NRPS,betalactone | 2,259,310 | 2,329,997 | Low | fengycin | NRPS:Type I
Region 6 | NI-siderophore | 2,438,006 | 2,472,695 | Medium | schizokinen | NRPS:Type IV
Region 7 | lanthipeptide-class-ii | 2,500,666 | 2,523,773 |
Region 8 | t3nrps-iterative,nucleoside | 2,556,126 | 2,614,072 |
Region 9 | opine-like-metallophore | 2,826,617 | 2,848,758 | High | bacillopaline | other:other
Region 10 | NRPS | 2,971,882 | 3,037,792 |
Region 11 | terpene | 3,746,656 | 3,768,512 |
Region 12 | T3PKS | 3,961,352 | 4,002,440 |
Region 13 | terpene | 4,241,893 | 4,262,711 |
Region 14 | lanthipeptide-class-ii | 4,288,134 | 4,317,016 |
Region 15 | azole-containing-RiPP | 4,988,825 | 5,012,370 |

NZ_CP063142.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 896,440 - 917,318 nt. (total: 20,879 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
HPB58_RS04670: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
HPB58_RS04700: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

HPB58_RS04705: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000665.5 |  | 0.39 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000668.5 |  | 0.38 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000641.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC416

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000665.5 |  | 0.39 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000668.5 |  | 0.38 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000641.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC416

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
HPB58_RS04700: PT_FPPS_like
Domain 1 (32 - 291): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.50 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.90 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.73 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.77 out of 20.97
Confidence: strong
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84
Confidence: medium
Additional weak hits (3):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.47 out of 30.11
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.70 out of 33.73
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis

NZ_CP063142.1 - Region 2 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,353,472 - 1,377,325 nt. (total: 23,854 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
HPB58_RS07035: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.4 |  | 0.70 | ribosomal | paeninodin | Paenibacillus dendritiformis C454
BGC0001634.3 |  | 0.53 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000571.3 |  | 0.50 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001779.5 |  | 0.46 | ribosomal | siamycin | Streptomyces nodosus
BGC0000623.3 |  | 0.43 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.42 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001210.5 |  | 0.41 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000617.5 |  | 0.41 | ribosomal | coagulin | Bacillus coagulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.4 |  | 0.70 | ribosomal | paeninodin | Paenibacillus dendritiformis C454
BGC0001634.3 |  | 0.53 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000571.3 |  | 0.50 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001779.5 |  | 0.46 | ribosomal | siamycin | Streptomyces nodosus
BGC0000623.3 |  | 0.43 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.42 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001210.5 |  | 0.41 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000617.5 |  | 0.41 | ribosomal | coagulin | Bacillus coagulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lassopeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.98 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.16 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.09 out of 24.78
Confidence: medium
Additional weak hits (1):
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.67 out of 29.51
Confidence: weak
Lasso peptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (1353471...1377325)
HPB58_RS07050
  RRE type: Stand_Alone_Lasso_RRE
  Location: 10 - 92
  Score: 86.2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_CP063142.1 - Region 3 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,395,535 - 1,447,169 nt. (total: 51,635 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
HPB58_RS07365: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase acetyltransferase aminotransferase
HPB58_RS07315: acetyl-CoA acetyltransferase

smcogs
  SMCOG1124: acetyl-CoA acetyltransferase

HPB58_RS07400: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

HPB58_RS07415: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: hydrolase
HPB58_RS07380: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Isomerases: isomerase mutase
HPB58_RS07370: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

HPB58_RS07430: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: ligase synthase
HPB58_RS07320: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

HPB58_RS07375: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

HPB58_RS07385: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

HPB58_RS07460: cobalamin synthesis protein/P47K family protein

smcogs
  SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001185.5 |  |  | 1.01 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  | 0.86 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  |  | 0.83 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002695.2 |  |  | 0.80 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0001132.4 |  |  | 0.76 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  | 0.71 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.5 |  | 0.79 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.74 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  | 0.73 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002695.2 |  | 0.72 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.68 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.54 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.36 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.76 out of 29.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.28 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
Additional weak hits (8):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.22 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.74 out of 30.11
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.61 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.43 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.38 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.62 out of 29.38
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.33 out of 29.25
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.16 out of 26.12
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 1395534 - 1447169:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
HPB58_RS07320: X
AMP-binding (8..381): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    SCNGHSLFLYGSYSLSSGAYEFYGASELSFVSVL
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

HPB58_RS07375: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (30..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SKSLYPLSSPGGGVQVGGAQQVYGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (88% 8Å match)
  Stachelhaus code match:
    90% (moderate)

HPB58_RS07385: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (461..858): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMTFDISALELQALVGGETNFYGPTETTIWSSS
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (91% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (1509..1920): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEINMYGITETTVHVSF
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization
ZuR variant 1 | Zinc-responsive repressor

NZ_CP063142.1 - Region 4 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,870,903 - 1,892,012 nt. (total: 21,110 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000925.5 |  | 0.28 | other (other) | quinolobactin | Pseudomonas fluorescens
BGC0001796.5 |  | 0.28 | NRPS | tauramamide | Brevibacillus laterosporus DSM 25
BGC0000938.5 |  | 0.26 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000453.5 |  | 0.23 | NRPS | valinomycin | Streptomyces tsusimaensis
BGC0000274.5 |  | 0.21 | PKS | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0002432.2 |  | 0.20 | NRPS | laterocidine | Brevibacillus laterosporus LMG 15441

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000925.5 |  | 0.28 | other (other) | quinolobactin | Pseudomonas fluorescens
BGC0001796.5 |  | 0.28 | NRPS | tauramamide | Brevibacillus laterosporus DSM 25
BGC0000938.5 |  | 0.26 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000453.5 |  | 0.23 | NRPS | valinomycin | Streptomyces tsusimaensis
BGC0000274.5 |  | 0.21 | PKS | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0002432.2 |  | 0.20 | NRPS | laterocidine | Brevibacillus laterosporus LMG 15441

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.74 out of 28.14
Confidence: strong
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.13 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.04 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.80 out of 29.38
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.41 out of 20.97
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.41 out of 20.97
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (9):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.37 out of 31.73
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.72 out of 36.54
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.44 out of 29.38
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 20.36 out of 29.51
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 25.17 out of 33.73
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.42 out of 29.65
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.76 out of 30.12
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 16.60 out of 30.12
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (1870902...1892012)
HPB58_RS09590
  RRE type: Pantocin_Microcin_RRE
  Location: 0 - 90
  Score: 64.2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MexT | Global virulence regulator
PerR | Peroxide regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP063142.1 - Region 5 - NRPS,betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,259,310 - 2,329,997 nt. (total: 70,688 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
HPB58_RS11600: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

HPB58_RS11625: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

HPB58_RS11635: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

HPB58_RS11680: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: PPTase carboxylase transferase
HPB58_RS11585: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

HPB58_RS11690: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

HPB58_RS11710: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Lyases: decarboxylase hydratase
HPB58_RS11570: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

HPB58_RS11705: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
HPB58_RS11565: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

HPB58_RS11665: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

HPB58_RS11685: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

HPB58_RS11700: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001928.2 |  |  | 0.34 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002164.2 |  |  | 0.33 | NRPS | peramine | Epichloe festucae
BGC0000888.5 |  |  | 0.32 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001135.5 |  |  | 0.32 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  |  | 0.31 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001184.4 |  |  | 0.30 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0001128.4 |  |  | 0.30 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.30 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  |  | 0.30 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000131.5 |  |  | 0.29 | PKS | pyrrolomycin | Streptomyces sp. UC 11065

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002164.2 |  | 0.66 | NRPS | peramine | Epichloe festucae
BGC0001135.5 |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001166.5 |  | 0.62 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.61 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.87 out of 21.55
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.85 out of 25.31
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.77 out of 26.06
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.99 out of 26.06
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.81 out of 28.14
Confidence: medium
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 31.33 out of 36.54
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.44 out of 28.14
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.96 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.41 out of 27.78
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.60 out of 32.93
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 28.19
Confidence: medium
Additional weak hits (7):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.61 out of 30.11
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.58 out of 36.54
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.03 out of 25.88
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.89 out of 31.73
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.81 out of 35.63
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.47 out of 30.98
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 2259309 - 2329997:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 2259309 - 2306320:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
HPB58_RS11565: X - Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (266..656): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FIIAFDISLLEVESLLAGELNIYGPTETTICAAV
  Nearest Stachelhaus code(s):
    Ala DILICALICK (44% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1303..1683): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDISFDLSVYDGNTLLSGDISMGGATEASIWSIY
  Nearest Stachelhaus code(s):
    Cys DLYNLSMIWK (82% 8Å match)
  Stachelhaus code match:
    100% (strong)

HPB58_RS11685: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (93..526): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    ala (Ala)

Stachelhaus prediction details:
  Stachelhaus sequence:
    VNYAWTMHIWGGFTSLVGENNTWGQTETAGSPIA
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
HgtR | Hydrogen-dependent regulator
IolR | Regulator of the inositol catabolism
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
PerR | Peroxide regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP063142.1 - Region 6 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,438,006 - 2,472,695 nt. (total: 34,690 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase oxygenase
HPB58_RS12405: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

HPB58_RS12465: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: aminotransferase
HPB58_RS12385: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: deacetylase
HPB58_RS12375: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Lyases: decarboxylase
HPB58_RS12390: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002633.2 |  | 0.65 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0001572.3 |  | 0.64 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002692.2 |  | 0.64 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002683.2 |  | 0.63 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0001478.5 |  | 0.61 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.3 |  | 0.60 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002469.2 |  | 0.59 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0002305.2 |  | 0.57 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002470.2 |  | 0.56 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002
BGC0001713.5 |  | 0.54 | other (other) | ochrobactin | Ochrobactrum anthropi

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002633.2 |  | 0.65 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0001572.3 |  | 0.64 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002692.2 |  | 0.64 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002683.2 |  | 0.63 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0001478.5 |  | 0.61 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.3 |  | 0.60 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002469.2 |  | 0.59 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0002305.2 |  | 0.57 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002470.2 |  | 0.56 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002
BGC0001713.5 |  | 0.54 | other (other) | ochrobactin | Ochrobactrum anthropi

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.18 out of 27.78
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.47 out of 29.38
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.69 out of 32.93
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (7):
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 24.52 out of 32.93
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.50 out of 36.54
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.82 out of 27.55
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.54 out of 28.14
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.63 out of 39.62
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.22 out of 32.74
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 25.59 out of 30.97
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
LexA variant 3 | Repressor of DNA damage response
RpoN | Regulator of nitrogen assimilation and virulence
ZuR variant 1 | Zinc-responsive repressor

NZ_CP063142.1 - Region 7 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,500,666 - 2,523,773 nt. (total: 23,108 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
HPB58_RS12610: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: protease
HPB58_RS12650: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
HPB58_RS12635: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.57 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.54 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.4 |  | 0.51 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000527.5 |  | 0.51 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000500.5 |  | 0.49 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001407.5 |  | 0.49 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.57 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.54 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.4 |  | 0.51 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000527.5 |  | 0.51 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000500.5 |  | 0.49 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001407.5 |  | 0.49 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for HPB58_RS12635

HPB58_RS12640
Leader:
MNSVEKTIMSWKNPEMRSNQVAASPVGEVSEKELLNAVGG
Core:
S D V S P Q T T W P C V V V I T S T I C
Core with dehydrations:
Dha D V Dha P Q Dhb Dhb W P Cys V V V I Dhb Dha Dhb I Cys

#### antiSMASH-DB 4.0 matches for HPB58_RS12640

100.0%
NZ_CP063142.1:
Lanthipeptides: HPB58_RS12640_lanthipeptide
1
S D V S P Q T T W P C V V V I T S T I C
20
S D V S P Q T T W P C V V V I T S T I C
1
S D V S P Q T T W P C V V V I T S T I C
20
40.0%
NZ_CP016020.1 and 49 others:
NZ_CP067069.1 Lanthipeptides: JCR32_RS24625_lanthipeptide NZ_CP067069.1 Lanthipeptides: JCR32_RS24620_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25380_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25375_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25370_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25365_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25360_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25355_lanthipeptide NZ_CP085413.1 Lanthipeptides: LIS80_RS25350_lanthipeptide NZ_JH792105.1 Lanthipeptides: II5_RS26950_lanthipeptide NZ_JH792105.1 Lanthipeptides: II5_RS26955_lanthipeptide NZ_JH792105.1 Lanthipeptides: II5_RS26960_lanthipeptide NZ_JH792240.1 Lanthipeptides: IIK_RS26240_lanthipeptide NZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19955_lanthipeptide NZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19940_lanthipeptide NZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19935_lanthipeptide NZ_MOOT01000061.1 Lanthipeptides: BK765_RS23995_lanthipeptide NZ_MOOT01000061.1 Lanthipeptides: BK765_RS23990_lanthipeptide NZ_MOOT01000061.1 Lanthipeptides: BK765_RS23985_lanthipeptide NZ_NTUF01000024.1 Lanthipeptides: CN379_RS26680_lanthipeptide NZ_NVCZ01000001.1 Lanthipeptides: COK75_RS01180_lanthipeptide NZ_NVDK01000008.1 Lanthipeptides: COK95_RS05665_lanthipeptide NZ_NVEA01000001.1 Lanthipeptides: COL15_RS00005_lanthipeptide NZ_NVEA01000001.1 Lanthipeptides: COL15_RS00010_lanthipeptide NZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08185_lanthipeptide NZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08180_lanthipeptide NZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08175_lanthipeptide NZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08190_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20670_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20665_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20660_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20655_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20650_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20645_lanthipeptide NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20675_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19555_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19550_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19545_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19540_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19535_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19530_lanthipeptide NZ_WBPC01000027.1 Lanthipeptides: F8159_RS19560_lanthipeptide NZ_WBPE01000025.1 Lanthipeptides: F8161_RS14445_lanthipeptide NZ_WBPE01000025.1 Lanthipeptides: F8161_RS14440_lanthipeptide NZ_WBPE01000025.1 Lanthipeptides: F8161_RS14435_lanthipeptide NZ_WBPK01000016.1 Lanthipeptides: F8167_RS15680_lanthipeptide NZ_WBPK01000016.1 Lanthipeptides: F8167_RS15675_lanthipeptide NZ_WBPK01000016.1 Lanthipeptides: F8167_RS15670_lanthipeptide NZ_WBPK01000016.1 Lanthipeptides: F8167_RS15685_lanthipeptide
Lanthipeptides: A9C19_RS17970_lanthipeptide
1
S D V S P Q T T W P C V V V I
15
S D V P+T T C V V I
1
S D V Q P E T T P L C V G V I
15
39.1%
NZ_KZ845663.1:
Lanthipeptides: DL897_RS01070_lanthipeptide
1
S D V S P Q T T W P C V V V I T S
17
S D P Q T T P C+ + S
1
S D T Q P Q T T V P C L A I T F S
17
with 46 more sequence matches
Only the first 10 are displayed here.
38.5%
NZ_JAOVZP010000016.1 and 3 others:
NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptide NZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptide NZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide
Lanthipeptides: OF830_RS26725_lanthipeptide
1
S D V S P Q T T W P C V V V I T S T I
19
S D V P+T T C V +T+ I
1
S D V Q P E T T P A C V T A L T T G I
19
38.5%
NZ_LDKE01000067.1:
Lanthipeptides: ABB04_RS19960_lanthipeptide
1
S D V S P Q T T W P C V V V I
15
S D V P+T T C V V I
1
S D V K P E T T P L C V G V I
15
35.7%
NZ_CP092966.1:
Lanthipeptides: KM149_RS02085_lanthipeptide
1
S D V S P Q T T W P C V V V I T S
17
S D V P+T T C V V I
1
S D V K P E T T P L C V G V I A G
17
35.7%
NZ_JACDUU010000003.1:
Lanthipeptides: HNQ85_RS08030_lanthipeptide
1
S D V S P Q T T W P C V V V I T S T I
19
D V P+T T P C I T I
1
G D V Q P E T T T P C A Y T I G V T I
19
34.6%
NZ_JACSMH010000008.1 and 2 others:
NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptide NZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide
Lanthipeptides: KNP89_RS14470_lanthipeptide
1
S D V S P Q T T W P C V V V I T S
17
D V P+T T C V V I
1
G D V Q P E T T P F C V G V I V G
17
33.3%
NZ_NHVL01000036.1:
Lanthipeptides: CEU70_RS27675_lanthipeptide
1
S D V S P Q T T W P C V V V I T S T
18
D V S P+T T C+ V +T
1
G D V S P E T T P V C I T V G A A T
18
31.2%
NZ_CP006058.1 and 25 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide
Lanthipeptides: BAMY6639_RS19790_lanthipeptide
1
S D V S P Q T T---W P C V V V I T S T I C
20
+D V+P T T P C V +T+ C
1
A D V T P H T T P S S L P C G V F V T A A F C
23
31.0%
NZ_JAOVZP010000016.1 and 3 others:
NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptide NZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptide NZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide
Lanthipeptides: OF830_RS26730_lanthipeptide
1
S D V S P Q T T W P C V V V I T
16
S D V P+T T C V T
1
S D V Q P E T T P A C A V A F T
16
30.8%
NZ_JACSPU010000002.1:
Lanthipeptides: H9630_RS06775_lanthipeptide
1
S D V S P Q T T W P C V V V I T S T I
19
S D V+P+T T C V + +
1
S D V A P E T T P A C V A A F A T G L
19
30.8%
NZ_JAQQWR010000009.1:
Lanthipeptides: PQ473_RS20185_lanthipeptide
1
S D V S P Q T T W P C V V V I T S T I
19
S D V+P+T T C I + +
1
S D V A P E T T P A C A A A I A T G M
19
allorf_2503905_2503991
Leader:
MRELKKKGHNIFYM
Core:
T K M L C S L I Y L S F F N
Core with dehydrations:
Dhb K M L Cys Dha L I Y L Dha F F N

#### antiSMASH-DB 4.0 matches for allorf_2503905_2503991

100.0%
NZ_CP063142.1:
Lanthipeptides: allorf_2503905_2503991_lanthipeptide
1
T K M L C S L I Y L S F F N
14
T K M L C S L I Y L S F F N
1
T K M L C S L I Y L S F F N
14
allorf_2520430_2520546
Leader:
MCTLVEFAIITAIRQFGIEKRFKAIVAM
Core:
L V A S Y D G S P C
Core with dehydrations:
L V A Dha Y D G Dha P Cys

#### antiSMASH-DB 4.0 matches for allorf_2520430_2520546

100.0%
NZ_CP063142.1:
Lanthipeptides: allorf_2520430_2520546_lanthipeptide
1
L V A S Y D G S P C
10
L V A S Y D G S P C
1
L V A S Y D G S P C
10
allorf_2523026_2523133
Leader:
MQIREVLFFA
Core:
K S V S D N T L N P S V I N G S R K M E N K P C S
Core with dehydrations:
K Dha V Dha D N Dhb L N P Dha V I N G Dha R K M E N K P Cys Dha

#### antiSMASH-DB 4.0 matches for allorf_2523026_2523133

100.0%
NZ_CP063142.1:
Lanthipeptides: allorf_2523026_2523133_lanthipeptide
1
K S V S D N T L N P S V I N G S R K M E N K P C S
25
K S V S D N T L N P S V I N G S R K M E N K P C S
1
K S V S D N T L N P S V I N G S R K M E N K P C S
25
20.0%
NZ_FNYZ01000007.1:
Lassopeptides: BMY84_RS29080_lassopeptide
5
D N T L N P S V
12
D+T L N P +
7
D D T L N P Q I
14

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.36 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.70 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
Additional weak hits (4):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.09 out of 29.38
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.39 out of 36.53
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.40 out of 36.53
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.41 out of 36.53
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

HPB58_RS12640 - Class II
  Cleavage pHMM score: -1.80
  RODEO score: 0
  Monoisotopic mass: 2009.0 Da
  Molecular weight: 2010.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2028.3 Da N = 1
    2046.3 Da N = 2
    2064.4 Da N = 3
    2082.4 Da N = 4
    2100.4 Da N = 5
allorf_2503905_2503991 - Class II
  Cleavage pHMM score: -2.90
  RODEO score: 0
  Monoisotopic mass: 1624.8 Da
  Molecular weight: 1626.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1644.0 Da N = 1
    1662.0 Da N = 2
allorf_2520430_2520546 - Class II
  Cleavage pHMM score: -5.90
  RODEO score: 0
  Monoisotopic mass: 974.4 Da
  Molecular weight: 975.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    993.1 Da N = 1
allorf_2523026_2523133 - Class II
  Cleavage pHMM score: -2.40
  RODEO score: 0
  Monoisotopic mass: 2596.3 Da
  Molecular weight: 2597.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2615.9 Da N = 1
    2633.9 Da N = 2
    2652.0 Da N = 3
    2670.0 Da N = 4
    2688.0 Da N = 5

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes

NZ_CP063142.1 - Region 8 - nucleoside,t3nrps-iterative
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,556,126 - 2,614,072 nt. (total: 57,947 nt) Show pHMM detection rules used
t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)
nucleoside: (LipM or LipV or LipU or TunD or pur6 or pur10 or nikJ or nikO or truD)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
HPB58_RS12965: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

Transferases: PPTase aminotransferase
HPB58_RS12945: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

HPB58_RS13040: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: hydrolase
HPB58_RS13055: hydrolase

smcogs
  SMCOG1179: hydrolase

Lyases: decarboxylase
HPB58_RS12985: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase
HPB58_RS12960: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

HPB58_RS13010: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | t3nrps-iterative | nucleoside | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000852.5 |  |  | 0.33 | other (other) | ectoine | Sporosarcina pasteurii
BGC0000919.5 |  |  | 0.28 | other (other) | phaseolotoxin | Pseudomonas syringae
BGC0001161.5 |  |  | 0.28 | PKS | 1-heptadecene | Moorea bouillonii PNG
BGC0000875.4 |  |  | 0.27 | other (nucleoside), saccharide | caprazamycin, caprazamycin aglycon | Streptomyces sp. MK730-62F2
BGC0002193.2 |  |  | 0.26 | other (other) | phenguignardic acid | Aspergillus terreus NIH2624
BGC0000872.5 |  |  | 0.25 | other (other) | A-90289 A, A-90289 B | Streptomyces sp. SANK 60405
BGC0001076.5 |  |  | 0.25 | other (nucleoside) | liposidomycin B, liposidomycin A, liposidomycin C, liposidomycin Z, liposidomycin H, liposidomycin G, liposidomycin L, liposidomycin M, liposidomycin K, liposidomycin N | Streptomyces sp. SN-1061M
BGC0002706.2 |  |  | 0.25 | NRPS | saframycin Mx1 | Myxococcus xanthus
BGC0000402.4 |  |  | 0.24 | NRPS | paenilarvin A, paenilarvin B, paenilarvin C | Paenibacillus larvae subsp. larvae DSM 25430
BGC0002633.2 |  |  | 0.24 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002193.2 |  | 0.59 | other (other) | phenguignardic acid | Aspergillus terreus NIH2624
BGC0001164.3 |  | 0.55 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0000852.5 |  | 0.48 | other (other) | ectoine | Sporosarcina pasteurii
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001891.3 |  | 0.46 | other (other) | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000875.4 |  | 0.45 | other (nucleoside), saccharide | caprazamycin, caprazamycin aglycon | Streptomyces sp. MK730-62F2
BGC0000513.3 |  | 0.45 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001831.3 |  | 0.45 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0000558.5 |  | 0.44 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001163.3 |  | 0.44 | PKS | 1-heptadecene | Moorea producens 3L

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.39 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.98 out of 27.78
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.35 out of 27.55
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.31 out of 24.78
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.85 out of 24.78
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.16 out of 24.78
Confidence: medium
Additional weak hits (4):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.41 out of 25.75
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.28 out of 29.72
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.78 out of 29.51
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.34 out of 33.14
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS substrates
TFBS Finder
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
HPB58_RS12960: fatty_acid
CAL_domain (167..477): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 107.1
  NH2: 8.7
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

HPB58_RS13010: X
AMP-binding (19..408): X
nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    NSHLFGYCTAQCTATYGGALETYGLTEAGPRITA
  Nearest Stachelhaus code(s):
    Suc ALQSTGTPRK (44% 8Å match)
  Stachelhaus code match:
    60% (weak)

HPB58_RS13025: X
AMP-binding (62..264): X
No predictions made
Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
PerR | Peroxide regulator
ToxT | Regulator of MSHA biosynthesis

NZ_CP063142.1 - Region 9 - opine-like-metallophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,826,617 - 2,848,758 nt. (total: 22,142 nt) Show pHMM detection rules used
opine-like-metallophore: (CntL and CntM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | opine-like-metallophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002488.3 |  | 0.83 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002487.3 |  | 0.79 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002489.2 |  | 0.53 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0002490.2 |  | 0.50 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002322.3 |  | 0.41 | ribosomal | citrocin | Citrobacter pasteurii
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000519.4 |  | 0.40 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002488.3 |  | 0.83 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002487.3 |  | 0.79 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002489.2 |  | 0.53 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0002490.2 |  | 0.50 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002322.3 |  | 0.41 | ribosomal | citrocin | Citrobacter pasteurii
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000519.4 |  | 0.40 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.56 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.34 out of 27.78
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.07 out of 24.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19
Confidence: medium
Additional weak hits (5):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.45 out of 30.97
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.60 out of 27.04
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.64 out of 29.72
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.34 out of 39.62
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.46 out of 35.63
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
LexA variant 2 | Repressor of DNA damage response
ZuR variant 1 | Zinc-responsive repressor

NZ_CP063142.1 - Region 10 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,971,882 - 3,037,792 nt. (total: 65,911 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
HPB58_RS14980: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Hydrolases: hydrolase
HPB58_RS15015: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Lyases: dehydratase
HPB58_RS15020: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase
HPB58_RS15030: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

HPB58_RS15035: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

HPB58_RS15040: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.4 |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001133.4 |  | 0.74 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001825.4 |  | 0.73 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.4 |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001133.4 |  | 0.74 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001825.4 |  | 0.73 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.86 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.97 out of 20.97
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.97 out of 20.97
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.21 out of 26.06
Confidence: medium
Additional weak hits (4):
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.65 out of 22.40
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.32 out of 27.04
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.81 out of 29.65
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.40 out of 30.98
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 13, location 2971881 - 3037792:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Thr) + (X - Ala) + (Ser - Leu - D-X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
HPB58_RS15030: Ser - Leu - X - X
Search NORINE for peptide: strict or relaxed
AMP-binding (496..901): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFTSGESNLYGPTEATVDVTY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1558..1945): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWHAFDSAVQEPFAITGGDINQYGPSENTVVTTD
  Nearest Stachelhaus code(s):
    Pro DVQFIAQVVK (56% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (2600..3000): X
nrpys: Gln, Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDVSIQQMDILIGGEYNVYGPTECTVDATC
  Nearest Stachelhaus code(s):
    Gln or Glu DAQDLGVVDK (82% 8Å match)
    Ile DAQDLGVVDK (79% 8Å match)
    Gln DAQDLGVVDK (74% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (4116..4516): X
nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDVSIQQMDILFGGEYNMYGPTECTVNATC
  Nearest Stachelhaus code(s):
    Gln or Glu DAQDLGVVDK (76% 8Å match)
    Ile DAQDLGVVDK (74% 8Å match)
    Dpr DAQDLAVVNK (65% 8Å match)
    Cap DPQDIGIVNK (59% 8Å match)
  Stachelhaus code match:
    70% (weak)

HPB58_RS15035: X - Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (466..870): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWMTFDVSVWEWQFFSGGETNFYGPTEATIYVNA
  Nearest Stachelhaus code(s):
    Glu DVWHFGRINK (71% 8Å match)
    Gln DAWQFGLIDK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1527..1919): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    ala (Ala)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWATFDLSVFEVNTNLAGEYNLYGPSEDTTYSTY
  Nearest Stachelhaus code(s):
    Ala DLFNNALTYK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

HPB58_RS15040: Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (457..866): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CcpA | Catabolite control protein A
MogR | Repressor of flagellar motility genes

NZ_CP063142.1 - Region 11 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,746,656 - 3,768,512 nt. (total: 21,857 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: peptidase
HPB58_RS18695: gamma-glutamyltranspeptidase

smcogs
  SMCOG1274: gamma-glutamyltranspeptidase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000670.4 |  | 0.34 | terpene | thalianol, thaliandiol, thalianin | Arabidopsis thaliana
BGC0001736.3 |  | 0.31 | NRPS | pepteridine A, pepteridine B | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000249.5 |  | 0.28 | PKS | nogalamycin | Streptomyces nogalater
BGC0000627.4 |  | 0.28 | ribosomal | ustiloxin B | Aspergillus flavus NRRL3357
BGC0002359.3 |  | 0.25 | NRPS | dudomycin A | Streptomyces albus subsp. chlorinus
BGC0002789.2 |  | 0.25 | PKS | pentamycin, filipin | Streptomyces lavendulae strain YAKB-15
BGC0001394.5 |  | 0.24 | NRPS, PKS | phenalamide A2 | Myxococcus stipitatus DSM 14675
BGC0001567.4 |  | 0.24 | NRPS | cysteoamide | Streptomyces lincolnensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000670.4 |  | 0.34 | terpene | thalianol, thaliandiol, thalianin | Arabidopsis thaliana
BGC0001736.3 |  | 0.31 | NRPS | pepteridine A, pepteridine B | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000249.5 |  | 0.28 | PKS | nogalamycin | Streptomyces nogalater
BGC0000627.4 |  | 0.28 | ribosomal | ustiloxin B | Aspergillus flavus NRRL3357
BGC0002359.3 |  | 0.25 | NRPS | dudomycin A | Streptomyces albus subsp. chlorinus
BGC0002789.2 |  | 0.25 | PKS | pentamycin, filipin | Streptomyces lavendulae strain YAKB-15
BGC0001394.5 |  | 0.24 | NRPS, PKS | phenalamide A2 | Myxococcus stipitatus DSM 14675
BGC0001567.4 |  | 0.24 | NRPS | cysteoamide | Streptomyces lincolnensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
HPB58_RS18675: T2TS
Domain 1 (4 - 617): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.45 out of 23.79
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
Additional weak hits (7):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.67 out of 30.22
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.78 out of 26.12
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.64 out of 30.97
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.57 out of 29.72
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.26 out of 29.25
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 20.48 out of 29.51
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.52 out of 30.25
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
IolR | Regulator of the inositol catabolism

NZ_CP063142.1 - Region 12 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,961,352 - 4,002,440 nt. (total: 41,089 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
HPB58_RS19775: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

HPB58_RS19880: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Transferases: methyltransferase
HPB58_RS19850: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: dehalogenase hydrolase
HPB58_RS19765: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

HPB58_RS19795: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

HPB58_RS19810: haloalkane dehalogenase

smcogs
  SMCOG1262: haloalkane dehalogenase

Ligases: synthase
HPB58_RS19855: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001962.3 |  | 0.49 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0002332.2 |  | 0.48 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001647.3 |  | 0.43 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001735.5 |  | 0.42 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus
BGC0001521.3 |  | 0.41 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0002402.2 |  | 0.41 | terpene | Yossoside I, Yossoside II, Yossoside III, Yossoside IV, Yossoside V | Spinacia oleracea
BGC0002407.3 |  | 0.40 | other (other), saccharide | angustmycin A, angustmycin C | Streptomyces angustmyceticus
BGC0001267.3 |  | 0.40 | terpene | elymoclavine, Agroclavine I | Claviceps fusiformis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001962.3 |  | 0.49 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0002332.2 |  | 0.48 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001647.3 |  | 0.43 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001735.5 |  | 0.42 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus
BGC0001521.3 |  | 0.41 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0002402.2 |  | 0.41 | terpene | Yossoside I, Yossoside II, Yossoside III, Yossoside IV, Yossoside V | Spinacia oleracea
BGC0002407.3 |  | 0.40 | other (other), saccharide | angustmycin A, angustmycin C | Streptomyces angustmyceticus
BGC0001267.3 |  | 0.40 | terpene | elymoclavine, Agroclavine I | Claviceps fusiformis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.46 out of 29.25
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 28.14 out of 28.14
Confidence: strong
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.44 out of 28.14
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.04 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.28 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.70 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.54 out of 29.38
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.95 out of 26.06
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.96 out of 30.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.19 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.97 out of 21.55
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.87 out of 27.55
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.73 out of 32.93
Confidence: medium
Additional weak hits (6):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.50 out of 29.38
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.36 out of 29.38
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.80 out of 29.65
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.63 out of 30.98
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.13 out of 20.01
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
PerR | Peroxide regulator
SypG | Regulator of biofilm formation and host colonization
ZuR variant 1 | Zinc-responsive repressor

NZ_CP063142.1 - Region 13 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,241,893 - 4,262,711 nt. (total: 20,819 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
HPB58_RS21250: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Hydrolases: deacetylase
HPB58_RS21185: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000923.3 |  | 0.40 | other (other) | paerucumarin | Pseudomonas aeruginosa PAO1
BGC0000846.5 |  | 0.38 | other (other) | tabtoxin | Pseudomonas syringae
BGC0000925.5 |  | 0.37 | other (other) | quinolobactin | Pseudomonas fluorescens
BGC0001221.5 |  | 0.34 | other (phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509
BGC0001387.5 |  | 0.31 | other (other) | nucleocidin | Streptomyces calvus
BGC0002443.3 |  | 0.30 | PKS | mycemycin C, mycemycin A, mycemycin B | Streptomyces olivaceus
BGC0001940.3 |  | 0.30 | PKS | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0000197.5 |  | 0.28 | PKS, saccharide | aranciamycin | Streptomyces echinatus
BGC0001622.5 |  | 0.27 | PKS | isatropolone A, isotropolone B, isotropolone C | Streptomyces sp.
BGC0000193.3 |  | 0.27 | PKS | aclacinomycin | Streptomyces galilaeus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000923.3 |  | 0.40 | other (other) | paerucumarin | Pseudomonas aeruginosa PAO1
BGC0000846.5 |  | 0.38 | other (other) | tabtoxin | Pseudomonas syringae
BGC0000925.5 |  | 0.37 | other (other) | quinolobactin | Pseudomonas fluorescens
BGC0001221.5 |  | 0.34 | other (phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509
BGC0001387.5 |  | 0.31 | other (other) | nucleocidin | Streptomyces calvus
BGC0002443.3 |  | 0.30 | PKS | mycemycin C, mycemycin A, mycemycin B | Streptomyces olivaceus
BGC0001940.3 |  | 0.30 | PKS | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0000197.5 |  | 0.28 | PKS, saccharide | aranciamycin | Streptomyces echinatus
BGC0001622.5 |  | 0.27 | PKS | isatropolone A, isotropolone B, isotropolone C | Streptomyces sp.
BGC0000193.3 |  | 0.27 | PKS | aclacinomycin | Streptomyces galilaeus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | squalene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
HPB58_RS21225: PT_phytoene_like
Domain 1 (14 - 254): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → diapophytoene
  FPP → squalene
  FPP → PSPP
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.70 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.05 out of 18.16
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.38 out of 27.78
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.39 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.45 out of 27.78
Confidence: strong
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.07 out of 20.47
Confidence: medium
Additional weak hits (2):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.14 out of 25.88
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.01 out of 31.73
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP063142.1 - Region 14 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,288,134 - 4,317,016 nt. (total: 28,883 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
HPB58_RS21445: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
HPB58_RS21450: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

HPB58_RS21470: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Ligases: synthase
HPB58_RS21435: cobalamin synthesis protein/P47K family protein

smcogs
  SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000516.4 |  | 0.58 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.56 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000552.3 |  | 0.55 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000626.3 |  | 0.55 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001407.5 |  | 0.54 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000497.3 |  | 0.54 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0001391.3 |  | 0.53 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000623.3 |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000516.4 |  | 0.58 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.56 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000552.3 |  | 0.55 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000626.3 |  | 0.55 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001407.5 |  | 0.54 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000497.3 |  | 0.54 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0001391.3 |  | 0.53 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000623.3 |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for HPB58_RS21450

HPB58_RS21455
Leader:
MKKNMKAIEEVSEQELKELAGG
Core:
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
Core with dehydrations:
A E E R A I W Dhb V Dhb I P I Dha L A A Cys P Dhb Dhb Q Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for HPB58_RS21455

100.0%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
81.2%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R W T+ I P I S L A A C P T T+C A S I V S P C N
1
A E E R--W T I I I P I S L A A C P T T R C A S I V S P C N G
30
78.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04080_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N
31
A+E R W T+ I P I S L A A C P T T+C A S I V S P C N
1
A D E R--W T I I I P I S L A A C P T T R C A S I V S P C N
29
with 69 more sequence matches
Only the first 10 are displayed here.
78.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R W T+ I P I S L A A C P T T+C A S I V S C N
1
A E E R--W T I I I P I S L A A C P T T R C A S I V S S C N G
30
67.6%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E + T V T I P I S A C P T T Q C A S I V P C N+
2
A E P Q G T P T V T I P I S A A I C P T T Q C A S I V R P C N N
33
65.6%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide
Lanthipeptides: HPB58_RS21460_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A E E R A I W T V T I P I S L A A C P T T
1
A E E R A I W T V T I P I S L A A C P T T
21
64.7%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide
Lanthipeptides: BK581_RS20095_lanthipeptide
2
E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N
31
+ A W T+T I P I S A A C P T T Q C A S+V P C N
4
N Q P A T W T I T I P I S A A A C P T T Q C A S V V K P C N
33
60.0%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S L A C P T T+C A S I V S P C
11
T V T I P I S L A G C P T T K C A S I V S P C K G
35
54.5%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
+E + I P+S L A C P T T+C A S+V P C N D
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N D
33
53.1%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide
Lanthipeptides: FE328_RS09035_lanthipeptide
7
W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
W T +P I S L A C P+T+C A S I P C N
3
W T S L V P I S L A I C P S T K C A S I T R P C N K
28
51.5%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
+E + I P+S L A C P T T+C A S+V P C N
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N G
33
50.0%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S C P T T+C A S+V P C N D
14
T V T I P I S A W G C P T T K C A S V V E P C N D
38
50.0%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S C P T T+C A S+V P C N D
14
T V T I P I S A W G C P T T K C A S V V K P C N D
38

#### MIBiG 4.0 matches for HPB58_RS21455

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
V T I P I S L A A C P T T Q C A S
25
V + +S A C P T T+C S
19
V A V G V S A A F C P T T K C T S
35
18.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
C P T T Q C A S
25
C P T T+C S
17
C P T T K C T S
24
HPB58_RS21460
Leader:
MKNVKAIEEVSEQELKELAGG
Core:
A E E R A I W T V T I P I S L A A C P T T
Core with dehydrations:
A E E R A I W Dhb V Dhb I P I Dha L A A Cys P Dhb Dhb

#### antiSMASH-DB 4.0 matches for HPB58_RS21460

65.6%
NZ_CP063142.1 and 7 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A E E R A I W T V T I P I S L A A C P T T
1
A E E R A I W T V T I P I S L A A C P T T
21
56.7%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A E E R W T+ I P I S L A A C P T T
1
A E E R--W T I I I P I S L A A C P T T
19
53.3%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04080_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A+E R W T+ I P I S L A A C P T T
1
A D E R--W T I I I P I S L A A C P T T
19
with 24 more sequence matches
Only the first 10 are displayed here.
41.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide
Lanthipeptides: EL241_RS13590_lanthipeptide
7
W T V T I P I S L A A C P T
20
W T V T+P+S+A C P T
3
W T V T V P L S I A L C P T
16
41.2%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A E + T V T I P I S A C P T T
2
A E P Q G T P T V T I P I S A A I C P T T
22
41.2%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide
Lanthipeptides: BK581_RS20095_lanthipeptide
2
E E R A I W T V T I P I S L A A C P T T
21
+ A W T+T I P I S A A C P T T
4
N Q P A T W T I T I P I S A A A C P T T
23
39.1%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide
Lanthipeptides: HBA49_RS00775_lanthipeptide
11
I P I S L A A C P T T
21
I P I S+A C P T T
7
I P I S I A L C P T T
17
37.1%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
8
T V T I P I S L A A C P T T
21
T V T I P I S L A C P T T
11
T V T I P I S L A G C P T T
24
35.7%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide
Lanthipeptides: FE328_RS09035_lanthipeptide
7
W T V T I P I S L A A C P T T
21
W T +P I S L A C P+T
3
W T S L V P I S L A I C P S T
17
30.3%
NZ_BOSN01000007.1 and 5 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
+E + I P+S L A C P T T
2
S E P Q G T P A T I I P V S L A I C P T T
22
29.4%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
8
T V T I P I S L A A C P T T
21
T I P+S L A C P T T
10
T T I I P V S L A V C P T T
23
28.9%
NZ_AUCI01000015.1 and 3 others:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
8
T V T I P I S L A A C P T T
21
T V T I P I S C P T T
14
T V T I P I S A W G C P T T
27
26.5%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
11
I P I S L A A C P T T
21
I P+S L A C P T T
13
I P V S L A I C P T T
23

#### MIBiG 4.0 matches for HPB58_RS21460

18.9%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
V T I P I S L A A C P T T
21
V + +S A C P T T
19
V A V G V S A A F C P T T
31
15.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
17
A C P T T
21
C P T T
16
F C P T T
20
HPB58_RS21475
Leader:
MEERLYGFAGKLEEELEEIALKEISGG
Core:
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
Core with dehydrations:
A E Q R G I Dha Q G N D G H Q Cys Dhb I Dhb W E Cys Dha I Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for HPB58_RS21475

100.0%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
84.4%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S Q G N D G C T I T W E C S I C P T H T C W C
2
A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
83.9%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A+ +G I S Q G N D G C T I T W E C S I C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
with 104 more sequence matches
Only the first 10 are displayed here.
81.2%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C-W C
31
A E Q R G I S Q G N D G C T+T W E C S+C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
81.2%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S Q G N D G C T+T W E C S I C P T H T C W C
2
A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
78.8%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E R G I S Q G N D G C T I T W E C +C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
75.0%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S+ N D G C T+T W E C S I C P T H T C W C
2
A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
72.7%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
E R G+S Q G N D G C T I T W E C +C P T H T C W C
3
V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
71.0%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E +G+S Q G N D G C T+T W E C +C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
68.4%
NC_023073.1 and 73 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
65.8%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G C T+T W E C +C P T H T C+C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
65.6%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15515_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W
30
E + I S+G N D G C T+T W E C S I C P T T C W
1
V E T K K I S K G N D G K W C T L T W E C S I C P T K T C W
30
50.0%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
4
R G I S Q G N D G H Q C T I T W E C S I C P T H T C W
30
R +S+G N G C T+T W E C I C P+H T C+
7
R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for HPB58_RS21475

25.8%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
9
G N D G H Q C T I T W E C
21
G N G C T+T E C
11
G N K G A Y C T L T V E C
23
25.8%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
9
G N D G H Q C T I T W E C
21
G N+G C T+T E C
13
G N N G G W C T L T K E C
25
10.3%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
15
C T I T W E C
21
C T++ E C
28
C T L S K E C
34
allorf_4307035_4307148
Leader:
MEREVLAYP
Core:
S F K Y R R T L T I F K R Y S V L C S Y P V Y K T T I V
Core with dehydrations:
Dha F K Y R R Dhb L Dhb I F K R Y Dha V L Cys Dha Y P V Y K Dhb Dhb I V

#### antiSMASH-DB 4.0 matches for allorf_4307035_4307148

100.0%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: allorf_4307035_4307148_lanthipeptide
Lanthipeptides: allorf_4307035_4307148_lanthipeptide
1
S F K Y R R T L T I F K R Y S V L C S Y P V Y K T T I V
28
S F K Y R R T L T I F K R Y S V L C S Y P V Y K T T I V
1
S F K Y R R T L T I F K R Y S V L C S Y P V Y K T T I V
28
58.3%
NZ_FOXX01000007.1 and 6 others:
NZ_LVYL01000023.1 Lanthipeptides: allorf_421773_421910_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: allorf_421773_421910_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021388_021525_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021388_021525_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: allorf_188984_189121_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: allorf_188984_189121_lanthipeptide
Lanthipeptides: allorf_282390_282527_lanthipeptide
1
S F K Y R R T L T I F K R Y S V L C S Y P V Y K
24
S F K Y R T L T I F K R Y S V L C S Y P K
1
S F K Y R S T L T I F K R Y S V L C S Y P F T K
24
22.2%
NZ_CP076356.1:
Lanthipeptides: allorf_0465169_0465315_lanthipeptide
11
F K R Y S V L C S Y P V Y K T T I V
28
F K R S L C S T
9
F K R S S E L C S D N S C G T A A C
26
with 1 more sequence matches
17.9%
NZ_KB235948.1 and 1 other:
NZ_KB235948.1 Lanthipeptides: allorf_4824400_4824492_lanthipeptide
Lanthipeptides: allorf_4824400_4824492_lanthipeptide
16
V L C S Y P V Y K T T I
27
+L C P Y+T +
6
I L C P S P A Y R T V L
17
allorf_4307377_4307535
Leader:
MGFKSISFTINFYIFILIQIFSKFSERFHSENRILFA
Core:
F F T M I D C N N L H I A V R
Core with dehydrations:
F F Dhb M I D Cys N N L H I A V R

#### antiSMASH-DB 4.0 matches for allorf_4307377_4307535

100.0%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: allorf_4307377_4307535_lanthipeptide
Lanthipeptides: allorf_4307377_4307535_lanthipeptide
1
F F T M I D C N N L H I A V R
15
F F T M I D C N N L H I A V R
1
F F T M I D C N N L H I A V R
15
93.3%
NZ_LVYL01000023.1 and 1 other:
NZ_LVYL01000023.1 Lanthipeptides: allorf_422114_422272_lanthipeptide
Lanthipeptides: allorf_422114_422272_lanthipeptide
2
F T M I D C N N L H I A V R
15
F T M I D C N N L H I A V R
2
F T M I D C N N L H I A V R
15
86.7%
NZ_FOXX01000007.1 and 2 others:
NZ_LWAG01000015.1 Lanthipeptides: allorf_021729_021887_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021729_021887_lanthipeptide
Lanthipeptides: allorf_282028_282186_lanthipeptide
2
F T M I D C N N L H I A V R
15
F T M I D C N N L H A V R
2
F T M I D C N N L H T A V R
15
with 2 more sequence matches
80.0%
NZ_LWAI01000057.1 and 1 other:
NZ_LWAI01000057.1 Lanthipeptides: allorf_188622_188780_lanthipeptide
Lanthipeptides: allorf_188622_188780_lanthipeptide
2
F T M I D C N N L H I A V R
15
F T M I D C N N L H +V R
2
F T M I D C N N L H T S V R
15
66.7%
NZ_JALAMS010000001.1 and 1 other:
NZ_JALAMS010000001.1 Lanthipeptides: allorf_278861_279019_lanthipeptide
Lanthipeptides: allorf_278861_279019_lanthipeptide
5
I D C N N L H I A V R
15
I D C N N L H A V R
1
I D C N N L H T A V R
11

#### Lanthipeptide(s) for HPB58_RS21470

HPB58_RS21455
Leader:
MKKNMKAIEEVSEQELKELAGG
Core:
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
Core with dehydrations:
A E E R A I W Dhb V Dhb I P I Dha L A A Cys P Dhb Dhb Q Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for HPB58_RS21455

100.0%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
81.2%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R W T+ I P I S L A A C P T T+C A S I V S P C N
1
A E E R--W T I I I P I S L A A C P T T R C A S I V S P C N G
30
78.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04080_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N
31
A+E R W T+ I P I S L A A C P T T+C A S I V S P C N
1
A D E R--W T I I I P I S L A A C P T T R C A S I V S P C N
29
with 69 more sequence matches
Only the first 10 are displayed here.
78.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R W T+ I P I S L A A C P T T+C A S I V S C N
1
A E E R--W T I I I P I S L A A C P T T R C A S I V S S C N G
30
67.6%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E + T V T I P I S A C P T T Q C A S I V P C N+
2
A E P Q G T P T V T I P I S A A I C P T T Q C A S I V R P C N N
33
65.6%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide
Lanthipeptides: HPB58_RS21460_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A E E R A I W T V T I P I S L A A C P T T
1
A E E R A I W T V T I P I S L A A C P T T
21
64.7%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide
Lanthipeptides: BK581_RS20095_lanthipeptide
2
E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N
31
+ A W T+T I P I S A A C P T T Q C A S+V P C N
4
N Q P A T W T I T I P I S A A A C P T T Q C A S V V K P C N
33
60.0%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S L A C P T T+C A S I V S P C
11
T V T I P I S L A G C P T T K C A S I V S P C K G
35
54.5%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
+E + I P+S L A C P T T+C A S+V P C N D
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N D
33
53.1%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide
Lanthipeptides: FE328_RS09035_lanthipeptide
7
W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
W T +P I S L A C P+T+C A S I P C N
3
W T S L V P I S L A I C P S T K C A S I T R P C N K
28
51.5%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
+E + I P+S L A C P T T+C A S+V P C N
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N G
33
50.0%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S C P T T+C A S+V P C N D
14
T V T I P I S A W G C P T T K C A S V V E P C N D
38
50.0%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S C P T T+C A S+V P C N D
14
T V T I P I S A W G C P T T K C A S V V K P C N D
38

#### MIBiG 4.0 matches for HPB58_RS21455

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
V T I P I S L A A C P T T Q C A S
25
V + +S A C P T T+C S
19
V A V G V S A A F C P T T K C T S
35
18.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
C P T T Q C A S
25
C P T T+C S
17
C P T T K C T S
24
HPB58_RS21460
Leader:
MKNVKAIEEVSEQELKELAGG
Core:
A E E R A I W T V T I P I S L A A C P T T
Core with dehydrations:
A E E R A I W Dhb V Dhb I P I Dha L A A Cys P Dhb Dhb

#### antiSMASH-DB 4.0 matches for HPB58_RS21460

65.6%
NZ_CP063142.1 and 7 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A E E R A I W T V T I P I S L A A C P T T
1
A E E R A I W T V T I P I S L A A C P T T
21
56.7%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A E E R W T+ I P I S L A A C P T T
1
A E E R--W T I I I P I S L A A C P T T
19
53.3%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04080_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A+E R W T+ I P I S L A A C P T T
1
A D E R--W T I I I P I S L A A C P T T
19
with 24 more sequence matches
Only the first 10 are displayed here.
41.7%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide
Lanthipeptides: EL241_RS13590_lanthipeptide
7
W T V T I P I S L A A C P T
20
W T V T+P+S+A C P T
3
W T V T V P L S I A L C P T
16
41.2%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A E + T V T I P I S A C P T T
2
A E P Q G T P T V T I P I S A A I C P T T
22
41.2%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide
Lanthipeptides: BK581_RS20095_lanthipeptide
2
E E R A I W T V T I P I S L A A C P T T
21
+ A W T+T I P I S A A C P T T
4
N Q P A T W T I T I P I S A A A C P T T
23
39.1%
NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide
Lanthipeptides: HBA49_RS00775_lanthipeptide
11
I P I S L A A C P T T
21
I P I S+A C P T T
7
I P I S I A L C P T T
17
37.1%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
8
T V T I P I S L A A C P T T
21
T V T I P I S L A C P T T
11
T V T I P I S L A G C P T T
24
35.7%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide
Lanthipeptides: FE328_RS09035_lanthipeptide
7
W T V T I P I S L A A C P T T
21
W T +P I S L A C P+T
3
W T S L V P I S L A I C P S T
17
30.3%
NZ_BOSN01000007.1 and 5 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
+E + I P+S L A C P T T
2
S E P Q G T P A T I I P V S L A I C P T T
22
29.4%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
8
T V T I P I S L A A C P T T
21
T I P+S L A C P T T
10
T T I I P V S L A V C P T T
23
28.9%
NZ_AUCI01000015.1 and 3 others:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
8
T V T I P I S L A A C P T T
21
T V T I P I S C P T T
14
T V T I P I S A W G C P T T
27
26.5%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
11
I P I S L A A C P T T
21
I P+S L A C P T T
13
I P V S L A I C P T T
23

#### MIBiG 4.0 matches for HPB58_RS21460

18.9%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
V T I P I S L A A C P T T
21
V + +S A C P T T
19
V A V G V S A A F C P T T
31
15.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
17
A C P T T
21
C P T T
16
F C P T T
20
HPB58_RS21475
Leader:
MEERLYGFAGKLEEELEEIALKEISGG
Core:
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
Core with dehydrations:
A E Q R G I Dha Q G N D G H Q Cys Dhb I Dhb W E Cys Dha I Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for HPB58_RS21475

100.0%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
84.4%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S Q G N D G C T I T W E C S I C P T H T C W C
2
A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
83.9%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A+ +G I S Q G N D G C T I T W E C S I C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
with 104 more sequence matches
Only the first 10 are displayed here.
81.2%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C-W C
31
A E Q R G I S Q G N D G C T+T W E C S+C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
81.2%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S Q G N D G C T+T W E C S I C P T H T C W C
2
A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
78.8%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E R G I S Q G N D G C T I T W E C +C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
75.0%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S+ N D G C T+T W E C S I C P T H T C W C
2
A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
72.7%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
E R G+S Q G N D G C T I T W E C +C P T H T C W C
3
V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
71.0%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E +G+S Q G N D G C T+T W E C +C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
68.4%
NC_023073.1 and 73 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
65.8%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G C T+T W E C +C P T H T C+C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
65.6%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15515_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W
30
E + I S+G N D G C T+T W E C S I C P T T C W
1
V E T K K I S K G N D G K W C T L T W E C S I C P T K T C W
30
50.0%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
4
R G I S Q G N D G H Q C T I T W E C S I C P T H T C W
30
R +S+G N G C T+T W E C I C P+H T C+
7
R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for HPB58_RS21475

25.8%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
9
G N D G H Q C T I T W E C
21
G N G C T+T E C
11
G N K G A Y C T L T V E C
23
25.8%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
9
G N D G H Q C T I T W E C
21
G N+G C T+T E C
13
G N N G G W C T L T K E C
25
10.3%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
15
C T I T W E C
21
C T++ E C
28
C T L S K E C
34
allorf_4307035_4307148
Leader:
MEREVLAYP
Core:
S F K Y R R T L T I F K R Y S V L C S Y P V Y K T T I V
Core with dehydrations:
Dha F K Y R R Dhb L Dhb I F K R Y Dha V L Cys Dha Y P V Y K Dhb Dhb I V

#### antiSMASH-DB 4.0 matches for allorf_4307035_4307148

100.0%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: allorf_4307035_4307148_lanthipeptide
Lanthipeptides: allorf_4307035_4307148_lanthipeptide
1
S F K Y R R T L T I F K R Y S V L C S Y P V Y K T T I V
28
S F K Y R R T L T I F K R Y S V L C S Y P V Y K T T I V
1
S F K Y R R T L T I F K R Y S V L C S Y P V Y K T T I V
28
58.3%
NZ_FOXX01000007.1 and 6 others:
NZ_LVYL01000023.1 Lanthipeptides: allorf_421773_421910_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: allorf_421773_421910_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021388_021525_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021388_021525_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: allorf_188984_189121_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: allorf_188984_189121_lanthipeptide
Lanthipeptides: allorf_282390_282527_lanthipeptide
1
S F K Y R R T L T I F K R Y S V L C S Y P V Y K
24
S F K Y R T L T I F K R Y S V L C S Y P K
1
S F K Y R S T L T I F K R Y S V L C S Y P F T K
24
22.2%
NZ_CP076356.1:
Lanthipeptides: allorf_0465169_0465315_lanthipeptide
11
F K R Y S V L C S Y P V Y K T T I V
28
F K R S L C S T
9
F K R S S E L C S D N S C G T A A C
26
with 1 more sequence matches
17.9%
NZ_KB235948.1 and 1 other:
NZ_KB235948.1 Lanthipeptides: allorf_4824400_4824492_lanthipeptide
Lanthipeptides: allorf_4824400_4824492_lanthipeptide
16
V L C S Y P V Y K T T I
27
+L C P Y+T +
6
I L C P S P A Y R T V L
17
allorf_4307377_4307535
Leader:
MGFKSISFTINFYIFILIQIFSKFSERFHSENRILFA
Core:
F F T M I D C N N L H I A V R
Core with dehydrations:
F F Dhb M I D Cys N N L H I A V R

#### antiSMASH-DB 4.0 matches for allorf_4307377_4307535

100.0%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: allorf_4307377_4307535_lanthipeptide
Lanthipeptides: allorf_4307377_4307535_lanthipeptide
1
F F T M I D C N N L H I A V R
15
F F T M I D C N N L H I A V R
1
F F T M I D C N N L H I A V R
15
93.3%
NZ_LVYL01000023.1 and 1 other:
NZ_LVYL01000023.1 Lanthipeptides: allorf_422114_422272_lanthipeptide
Lanthipeptides: allorf_422114_422272_lanthipeptide
2
F T M I D C N N L H I A V R
15
F T M I D C N N L H I A V R
2
F T M I D C N N L H I A V R
15
86.7%
NZ_FOXX01000007.1 and 2 others:
NZ_LWAG01000015.1 Lanthipeptides: allorf_021729_021887_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021729_021887_lanthipeptide
Lanthipeptides: allorf_282028_282186_lanthipeptide
2
F T M I D C N N L H I A V R
15
F T M I D C N N L H A V R
2
F T M I D C N N L H T A V R
15
with 2 more sequence matches
80.0%
NZ_LWAI01000057.1 and 1 other:
NZ_LWAI01000057.1 Lanthipeptides: allorf_188622_188780_lanthipeptide
Lanthipeptides: allorf_188622_188780_lanthipeptide
2
F T M I D C N N L H I A V R
15
F T M I D C N N L H +V R
2
F T M I D C N N L H T S V R
15
66.7%
NZ_JALAMS010000001.1 and 1 other:
NZ_JALAMS010000001.1 Lanthipeptides: allorf_278861_279019_lanthipeptide
Lanthipeptides: allorf_278861_279019_lanthipeptide
5
I D C N N L H I A V R
15
I D C N N L H A V R
1
I D C N N L H T A V R
11

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.04 out of 27.55
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.45 out of 27.78
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.17 out of 25.31
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.22 out of 18.16
Confidence: strong
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

HPB58_RS21455 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3233.6 Da
  Molecular weight: 3235.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3253.7 Da N = 1
    3271.7 Da N = 2
    3289.7 Da N = 3
    3307.8 Da N = 4
HPB58_RS21460 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 2152.2 Da
  Molecular weight: 2153.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2171.5 Da N = 1
    2189.5 Da N = 2
    2207.5 Da N = 3
    2225.6 Da N = 4
HPB58_RS21475 - Class II
  Cleavage pHMM score: -2.20
  RODEO score: 0
  Monoisotopic mass: 3355.4 Da
  Molecular weight: 3357.7 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3375.7 Da N = 1
allorf_4307035_4307148 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 3305.9 Da
  Molecular weight: 3307.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3325.9 Da N = 1
    3344.0 Da N = 2
    3362.0 Da N = 3
    3380.0 Da N = 4
    3398.0 Da N = 5
    3416.0 Da N = 6
allorf_4307377_4307535 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 1774.9 Da
  Molecular weight: 1776.1 Da
  Number of bridges: 1
HPB58_RS21455 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3233.6 Da
  Molecular weight: 3235.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3253.7 Da N = 1
    3271.7 Da N = 2
    3289.7 Da N = 3
    3307.8 Da N = 4
HPB58_RS21460 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 2152.2 Da
  Molecular weight: 2153.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2171.5 Da N = 1
    2189.5 Da N = 2
    2207.5 Da N = 3
    2225.6 Da N = 4
HPB58_RS21475 - Class II
  Cleavage pHMM score: -2.20
  RODEO score: 0
  Monoisotopic mass: 3355.4 Da
  Molecular weight: 3357.7 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3375.7 Da N = 1
allorf_4307035_4307148 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 3305.9 Da
  Molecular weight: 3307.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3325.9 Da N = 1
    3344.0 Da N = 2
    3362.0 Da N = 3
    3380.0 Da N = 4
    3398.0 Da N = 5
    3416.0 Da N = 6
allorf_4307377_4307535 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 1774.9 Da
  Molecular weight: 1776.1 Da
  Number of bridges: 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes

NZ_CP063142.1 - Region 15 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,988,825 - 5,012,370 nt. (total: 23,546 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
HPB58_RS24920: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

HPB58_RS24935: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: kinase
HPB58_RS24925: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001928.2 |  | 0.47 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002496.3 |  | 0.45 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0001173.5 |  | 0.44 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000569.5 |  | 0.43 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001928.2 |  | 0.47 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002496.3 |  | 0.45 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0001173.5 |  | 0.44 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000569.5 |  | 0.43 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.80 out of 32.93
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.87 out of 29.72
Confidence: medium
Additional weak hits (3):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.53 out of 29.25
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.33 out of 30.22
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (4988824...5012370)
HPB58_RS24965
  RRE type: Heterocycloanthracin_C_RRE
  Location: 0 - 99
  Score: 165.6
  RRE type: Thiopeptide_F_RRE
  Location: 7 - 89
  Score: 50.4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 3 | Repressor of DNA damage response
NtrC | Nitrogen regulatory protein C

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.