LOCUS       NZ_JAICDG010000008     22467 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinomadura terrae strain OS3-83 contig8, whole genome shotgun
            sequence.
ACCESSION   NZ_JAICDG010000008
VERSION     NZ_JAICDG010000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura terrae
  ORGANISM  Actinomadura terrae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 367201)
  AUTHORS   Lee,S.D., Yang,H.L., Kim,I.S., Choe,H. and Kim,J.S.
  TITLE     Actinomadura terrae sp. nov. and Actinomadura litoris OS3-89,
            isolated from rhizosphere soil of cactus
  JOURNAL   Int J Syst Evol Microbiol 73 (1) (2023)
   PUBMED   36748505
REFERENCE   2  (bases 1 to 367201)
  AUTHORS   Lee,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2022) Institute of Jeju Microbial Resources, BioPS
            Co., Ltd., Sancheondan Dongil 16, Jeju 63243, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 141x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022751215.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:12:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,085
            CDSs (total)                      :: 8,002
            Genes (coding)                    :: 7,936
            CDSs (with protein)               :: 7,936
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 2, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 13 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 3 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 287390
            Orig. end                         :: 309857
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAICDG010000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22467
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22467
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22467
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12467](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12467
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    14..28
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    218..236
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.57"
                     /tool="antismash"
     misc_feature    complement(226..241)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     gene            complement(298..1143)
                     /locus_tag="K2F47_RS37530"
     CDS             complement(298..1143)
                     /GO_function="GO:0008081 - phosphoric diester hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887165.1"
                     /locus_tag="K2F47_RS37530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycerophosphodiester phosphodiesterase family
                     protein"
                     /protein_id="WP_242911001.1"
                     /transl_table=11
                     /translation="MTRTVEVHGHRGARGLRPENTLPGFACALDLGVDAVELDVGLTSD
                     GVVVLCHDQVLSPVNLSDTRPARPGDPAFPYVGKAIRDLTLEQLKTVDAGVRQRDDMFT
                     ATQLPLPGTPIPTLAEACALLEPSRVLLSVELKTDPSWPDEDVARFVPAVASVLDEAGV
                     THRSRVLGFDWRVLAEAHRHPALGRVALVERKTLVPDTPWLAGLAPEDPIAAAVAIGAT
                     ALSPEHTLITPSLVDDAHAAALAVVAWTVNEREDMSRLAKYGVDAIVTDYPDRALTLSA
                     "
     gene            complement(1204..2487)
                     /locus_tag="K2F47_RS37535"
     CDS             complement(1204..2487)
                     /EC_number="6.3.4.4"
                     /GO_function="GO:0004019 - adenylosuccinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011293429.1"
                     /locus_tag="K2F47_RS37535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenylosuccinate synthase"
                     /protein_id="WP_242911002.1"
                     /transl_table=11
                     /translation="MPAIVLVGAQWGDEGKGKATDLLGGDVDYVVRYQGGNNAGHTVVI
                     GDKSYALHLLPSGVLSPDVVPVIGNGVVIDPAVLLQEIDGLRDRGITCERLLISGNAHL
                     IMPHHRALDKVTERYLGKARIGTTGRGIGPAYADKINRMGIRVQDLFDPNILNQKLDLS
                     LREKNQVLTKVYNRRRIETDPIVQEYLAYGERLRPFVADTSLVLNKALEDDKVVLLEGA
                     QGTLLDLDHGTYPFVTSSSPTAGGACAGSGIGPTRISRVIGILKAYTTRVGSGPFPTEL
                     LDEQGEYLRKTGGEYGVTTGRDRRCGWFDAVIARYATRVNGITDYFLTKLDVLSGLERV
                     PVCVAYEIDGERVEEMPTTQTDFHHAKPILEYLDGWKEDITAAKTFDDLPKTAQAYVRA
                     LEEMSGAQISAIGVGPGREQTLSLRSLI"
     gene            complement(2706..3116)
                     /locus_tag="K2F47_RS37540"
     CDS             complement(2706..3116)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012850593.1"
                     /locus_tag="K2F47_RS37540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3151 domain-containing protein"
                     /protein_id="WP_242911003.1"
                     /transl_table=11
                     /translation="MTNNLLGGLPPTELPDNAEAREALANDVDPFEVAARHPDYPGAWA
                     ELADRAFARGGVIDSYAFARTGYHRGLDQLRRAGWRGQGPVPWEHEPNRGFLRALHALA
                     RAAAAIGEDDEAERCRTFLKDSSPTAAEALGN"
     misc_feature    3201..3219
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.27"
                     /tool="antismash"
     gene            3219..4013
                     /locus_tag="K2F47_RS37545"
     CDS             3219..4013
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545939.1"
                     /locus_tag="K2F47_RS37545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_242911004.1"
                     /transl_table=11
                     /translation="MLTPGGIDTGVPSPARVYDCLLGGKDHYESDRRAAARLLEIVPSM
                     RLSATQNRAFLGRAVQYLAGEVGIRQFLDIGTGLPTQDNVHDVAQRIAPSSRIVYVDND
                     AVVLAHARALLTSTPEGATDYLDADLRDPDAILEHASRTLDLDRPVALLLVAVLHFVPD
                     ADDPRGIVSALLDRLVPGSYLVISHGGSDADPRKAAEATGVYRRHAPDALLSLRTESEV
                     ARFFDGLDLVEPGLGSIAHWRPAGPIPSAEQVGMHGGVARKP"
     misc_feature    3357..3359
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4010..4537)
                     /locus_tag="K2F47_RS37550"
     CDS             complement(4010..4537)
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012850594.1"
                     /locus_tag="K2F47_RS37550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_242911005.1"
                     /transl_table=11
                     /translation="MTRLTVRTVAHLPPPALEDVRIRPYGITDGPRLRRMSERLSKASL
                     YTRFFSGTPHIPDHYVRLLERLDHWDREALIALDADEIAGVAEYSRDRRRPWCADLAVL
                     VTDPWQRRGVGSALVRYLAQLAARRGITEFEADVIPGNRDALRFVQHGWPTARARTVDG
                     TAHFQLPLPVRP"
     gene            complement(4583..5032)
                     /locus_tag="K2F47_RS37555"
     CDS             complement(4583..5032)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012850595.1"
                     /locus_tag="K2F47_RS37555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_242911006.1"
                     /transl_table=11
                     /translation="MALPRTYESQNCSIARSLEVVGDRWTMLVIRTAFEGVRRFDDFQD
                     VLGVARNVLTDRLSRLCDEGIMRRVPYQDRPERFEYRLTRKGVELWPAMMSLLLWGDRH
                     YAPDGPPTLVGHRGCPGTLTASFTCDACGASLGPTDVEPRPGAGR"
     gene            complement(5098..6120)
                     /gene="fbaA"
                     /locus_tag="K2F47_RS37560"
     CDS             complement(5098..6120)
                     /EC_number="4.1.2.13"
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fbaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014912124.1"
                     /locus_tag="K2F47_RS37560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class II fructose-bisphosphate aldolase"
                     /protein_id="WP_242911007.1"
                     /transl_table=11
                     /translation="MPIATPEVYAEMLDRAKQDGFAYPAINVTSSQTLNAALRGFAEAE
                     SDGIVQVSTGGAEYLSGATVKDMVTGASALAEYARVVAAKYPVNIALHTDHCPKDKLDG
                     FMRPLVKISQERVARGEEPLFQSHMWDGSAVPLEENLQIAAELLDQCAKARIIMEMEIG
                     VVGGEEDGVANEINEKLYTTPGDALATAEAVGVGERGRYILAATFGNVHGVYKPGSVKL
                     RPEVLKGIQDAVGEKYGKDKPFDLVFHGGSGSTLEEIREAVSYGVVKMNIDTDTQYAFT
                     RPVADHMLRNYDGVLKVDGEVGNKKQYDPRSWGKAAEAAMAARVVQATEHLLSAGKRLK
                     "
     misc_feature    complement(6136..6149)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.22"
                     /tool="antismash"
     misc_feature    6359..6377
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.28"
                     /tool="antismash"
     gene            6437..7180
                     /locus_tag="K2F47_RS37565"
     CDS             6437..7180
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631871.1"
                     /locus_tag="K2F47_RS37565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DedA family protein"
                     /protein_id="WP_242911008.1"
                     /transl_table=11
                     /translation="MDLTTLPLDITEYLHPTAWLQLFGTFATIGVLAIIFAETGLLIGC
                     ILPGDSLLFTAGILTAVSTVNGQEFQSLSLPWLLVGGPVAAIAGAQLGHWLGARYGRKL
                     FERPDSKIFRQEWVEKAEYYFNRFGPAKAVVLARFVPIVRTFLNPLAGMLGMDARKFFI
                     WNVVGGVVWTDALFLLGHFLGSEVPDVERYILPGVAVILVLSVIPIIREVMKGRKASRG
                     GGKHSRPKNNGPEESRPSLSGDSYR"
     gene            7250..7657
                     /locus_tag="K2F47_RS37570"
     CDS             7250..7657
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631872.1"
                     /locus_tag="K2F47_RS37570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_242911009.1"
                     /transl_table=11
                     /translation="MVAALGLLVAGGLSLVNAVSGDSDNHDPATVSPSPGDGGQNKSAP
                     SRSPSSSSSGALPLVIRVTGPATNVLVRVADTGEVLTQALLSTGDTRKYEQTPLQVVAT
                     NGGSLEVVIYGRKWPAKPSGTRGQWFVSARK"
     gene            complement(7686..8204)
                     /locus_tag="K2F47_RS37575"
     CDS             complement(7686..8204)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012859.5"
                     /locus_tag="K2F47_RS37575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_242911010.1"
                     /transl_table=11
                     /translation="MRTFSILALLPAVTMAGALWAGSSASAPSSASAAPAPKPEKKLTG
                     FLVKPRAAGGLCLEVADGNTGNGALTTVWPCHGGANQRWSFDGGRLRSDLPGNKCLDVR
                     GGNGGSGAATNLYDCNGAAGQQWHFRGDNLVSGVNANCLTVVGANFAGGGAVVNWQCVN
                     GRDQAWEIS"
     gene            8357..9421
                     /locus_tag="K2F47_RS41620"
     CDS             8357..9421
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="K2F47_RS41620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_242911011.1"
                     /transl_table=11
                     /translation="MSAGRSAPGAALVGAATEVGSATELGAVISRWVGRAVPHEGYMLA
                     AVDPVTGAGCFLARGHGYTTAAARQLTLGERLNCDHPFPFQRLVAGPCHVGVLNTDGPV
                     RRRSPTMRAVMADLGVGSELRLALVDGGTTWGGLVLLRPRGARPFSPDEASRAQHLARD
                     IVAALRRYATGVPPEPNRLGAPPGVLVLGADETILSATPSARIWIRELETLPAAALAAP
                     DLPMESTIWHLTQSVRGPEEPTPTRGPGMPGLTRVPTPRGWIAIRAQPMPTGAIAVTIQ
                     AAAGKELLSAVALWQGLSPRERVVIDHVLEGLSSKQIARRLHVSPHTLNDHLKSIYRKA
                     GVSTREELLSRFLN"
     gene            9661..9780
                     /locus_tag="K2F47_RS37585"
     CDS             9661..9780
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="K2F47_RS37585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_242911012.1"
                     /transl_table=11
                     /translation="MSMAYEPPSLVVIGDLREITLGDRSWGFDRINQCAMWNC"
     gene            10001..11794
                     /locus_tag="K2F47_RS37590"
     CDS             10001..11794
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="K2F47_RS37590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_242911013.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.9e-41, bitscore:
                     136.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASLHTRWPDLRMLPHDSGRPWIVGHWQDEEVRWAAAGGRRIALL
                     GRVQVSVPWLTRYIVGQPEPGALADLSRELPGSYHTVAAMDRVVFVQGDLSTVREVFHG
                     QVLGVTIAADRPDGLAELADAAIAEEELAVRLLAPAVPWPLSEECLWKGIQALPSGCHL
                     RIGPDGRGRVTHGRSLPAPELPLAEGARRVRHALKEAVRVRTHGQAMLSADLSGGMDST
                     SVCFLAAGRVDRLLTVVCEPGDPSSDDGRWAALAATSLPGAEHMSYRAEDCPRYFAGLL
                     DTDPDLEAPLPSVHARAMVLEQARLMAAAGSSRHLTGHGGDELFLPTPAYLHDLLRRRP
                     LRAIGQLRAGRAVSRWQTRPTVAALLDRTSFADWLGHEIGRDLRNPIRGVGTAPLSGWG
                     PAYRMPAWATPEAVRSVQHRLREVARARPSPLSPLRGRHLTVQHIRQGGELVRRIDRLS
                     LQHGVTTEAPFLDDQVVEAALAVDYADCLRADRYKPVLVEAMRGIVPSRSLGRRSKAEF
                     SADLYTGLREHRHDLLELCDGMRLASLGLVDAAALRAVILSPPPVSLELLPLLNTFACE
                     VWLRSVGTGRPRSRAASEAGR"
     gene            11791..12042
                     /locus_tag="K2F47_RS37595"
     CDS             11791..12042
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033530.1"
                     /locus_tag="K2F47_RS37595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_242911014.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.7e-23,
                     bitscore: 77.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1e-13, bitscore: 45.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKICPDVTLTDTGQGLVLLNERTGRYWSLNGTGRAVLLMLADGAT
                     PEEAVDSLTRQHPDFADRITSDVEALIKSLLAEKVLLP"
     aSDomain        11800..12030
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K2F47_RS37595_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.30E-24"
                     /identifier="RREFam002.1"
                     /label="K2F47_RS37595"
                     /locus_tag="K2F47_RS37595"
                     /protein_end="80"
                     /protein_start="3"
                     /score="77.0"
                     /tool="antismash"
                     /translation="CPDVTLTDTGQGLVLLNERTGRYWSLNGTGRAVLLMLADGATPEE
                     AVDSLTRQHPDFADRITSDVEALIKSLLAEKV"
     gene            12039..12467
                     /locus_tag="K2F47_RS37600"
     CDS             12039..12467
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="K2F47_RS37600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_242911015.1"
                     /sec_met_domain="PF13471 (E-value: 1.4e-27, bitscore: 90.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMPVALEPRPDVSRGRRAAALAAVSAATLLERLPPRRLRRVLEA
                     ARRGARPATAAQALAAREAVVAVSLHCAGQGCLRRSVAVALLCRMGGSWPDWCTGVRVE
                     PFRAHAWVEVDGTAIGELDDMHLYHKTMTVPARRRGGR"
     gene            12470..13003
                     /locus_tag="K2F47_RS37605"
     CDS             12470..13003
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.5"
                     /locus_tag="K2F47_RS37605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_242911089.1"
                     /transl_table=11
                     /translation="MREAFALAAQSLTAGIFAVAAFSKLRGREDFERFATTVRKLTMRS
                     GPETTVLAGAFAVVEALTAVLIAVPATATAGLWTAAALLILFIGVVFRAVRGKVFAECG
                     CFGGSAIMSYPLLLRNLLLLALALAGLAAPAWEGLAVRGAALAAGLVAAPVLLRSYDRA
                     VTLVLGRVHARTQP"
     gene            13000..13944
                     /locus_tag="K2F47_RS37610"
     CDS             13000..13944
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017598346.1"
                     /locus_tag="K2F47_RS37610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_242911016.1"
                     /transl_table=11
                     /translation="MTAPIEVRGLSKHFGRVIALDAVDLTVPRGAVHGLLGHNGAGKST
                     LVGVLATLLRPTRGTVRVAGHDVLERPAQVRRRIALTGQQTTLDLTMSGRDNLFMTARL
                     LGAGRRAARARTDQLLEAFELTAAADRPARGYSGGMRRRLDLAMTLVRRSEVVFLDEPG
                     TGLDPASRLATWDMVRGLTATGSTVVLTTQHLEEADRLADAITVLADGRVVATGPPEDL
                     KRRIGRRSATVRLATAADTLAADRALTAAGLPPECDRPRRALTITLTRDRDLTAVVRVL
                     DAAGIEPTRLTLSEPGLDQVYLALTGHRRTEAP"
     gene            13941..14777
                     /locus_tag="K2F47_RS37615"
     CDS             13941..14777
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629987.1"
                     /locus_tag="K2F47_RS37615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_242911017.1"
                     /transl_table=11
                     /translation="MTAPPLTDHPHEPLTGSDDWHGAATTTQIAILTARSMRALVLDRR
                     LLIIGVVESLIMLIAFGQVFSGLAYAPGFPAHIKYIDFLFPALMLTTTLQSGIQAGIGV
                     TDDAQSGILDRLRSMPVWPGSILIARSLAGLARGALRLLVLLTLARALFGYHPAGGVEG
                     LLAAAALSLAVSWSLSWLFIALACWIHQSEALHATAGLVMFPLMYASNAFVPMDGLPGW
                     LRWIARYNPITHGINSARDLCLTGTTGPGVLTAILASLLIATAAATTATKALSRPR"
     gene            15265..15849
                     /locus_tag="K2F47_RS37620"
     CDS             15265..15849
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017496.5"
                     /locus_tag="K2F47_RS37620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_242911018.1"
                     /transl_table=11
                     /translation="MPTLTLPLPSGGTWTRADYEALPEDLPVRVSLIHGALVVAPRPRP
                     LHQRIARRLATRLEDAAPDAWQVDTAVDVLLDDDEVEAVEIAPDIVVYSSDHDPYERPI
                     LAHQVALVVEVVSPSTRHRDRRVQPALYAEAGIRHYWRVETDQTAPAFAVYTYELGDAT
                     GGYVATGVHHDRITATLPFALDIELKAVRER"
     repeat_region   15927..16219
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=303448..303477
                     /rpt_unit_seq="gttgcgaacccttgtaggggcgatgaggac"
     gene            complement(16478..16684)
                     /locus_tag="K2F47_RS37625"
     CDS             complement(16478..16684)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854399.1"
                     /locus_tag="K2F47_RS37625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_308198536.1"
                     /transl_table=11
                     /translation="MKITSTTSVQWRKSSYSGGSSGQCVEVARTATLLSIRDSKNPHSG
                     HLAIDRTAFTVLVSRAKAGNLDL"
     gene            complement(16681..17274)
                     /locus_tag="K2F47_RS37630"
     CDS             complement(16681..17274)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039589.4"
                     /locus_tag="K2F47_RS37630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5919 domain-containing protein"
                     /protein_id="WP_242911019.1"
                     /transl_table=11
                     /translation="MLWPKTVGRNIKIGADREIVAVYPYRSSCPKSVWRGLISNAKSEL
                     TFAGYTNYFLWLELPNLRSVLRRQAEAGCRIRFLIGDPNSEVTRRREELEAVPLTVSTR
                     IQVTMDELSKLSDVPTIETRYGDEHIGLSAFVFDDQMLVTPHLARLVGHDSPMLHIKRL
                     QDDGLYDRFASHVASLWELANHQAETDQHPMEEP"
     gene            complement(17375..17584)
                     /locus_tag="K2F47_RS37635"
     CDS             complement(17375..17584)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854096.1"
                     /locus_tag="K2F47_RS37635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_242911020.1"
                     /transl_table=11
                     /translation="MKTTDKLTSGPWRKSSYSGGQSGQCVEVAETYALVGIRDSKNPEG
                     GHLSIGRPAFAALVWRVKAGDLNL"
     gene            complement(17581..18087)
                     /locus_tag="K2F47_RS37640"
     CDS             complement(17581..18087)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.4"
                     /locus_tag="K2F47_RS37640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5753 domain-containing protein"
                     /protein_id="WP_242911021.1"
                     /transl_table=11
                     /translation="MIKVYENFVITGLFQAPDYARAVLKAGQQPNKLESLVTARLERQE
                     IINADEPPAIFALLDASVLRRPFGGREVMRAQLEHLLTLADLPHVHIHIVPEDAELSPE
                     GTFTILCSPGEPDTVYAESAGGRGRLIDEGDYVAELGILFELIRSKALNAEESTAAIRK
                     ALEEL"
     gene            complement(18094..18384)
                     /locus_tag="K2F47_RS37645"
     CDS             complement(18094..18384)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="K2F47_RS37645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_242911022.1"
                     /transl_table=11
                     /translation="MPSIDPSESARAYLAYHLKRLREEKGWSQPTLGSKIHVSGSLISG
                     METQQRRPTRRNCQALDRAFEQDQFFTPLYPRVLEETGLPAGFPEFADAEG"
     gene            18521..18844
                     /locus_tag="K2F47_RS37650"
     CDS             18521..18844
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS37650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242911023.1"
                     /transl_table=11
                     /translation="MCIDDTAGRTSQPGEPGYEREVSWLEDVVRALDMVGGFKTSMRQL
                     YGDGAPFLDVVGDGGARLKETVHVRWVGQSLRGVWSWGEDIAGDGDPQVAAEAIGRVVS
                     PRM"
     gene            18852..19214
                     /locus_tag="K2F47_RS37655"
     CDS             18852..19214
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS37655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242911024.1"
                     /transl_table=11
                     /translation="MGRHEKTPGNHPQPPSEVEQEGGPATFIPQSERVTFLVHLAREFE
                     DAAGLMTVFAVLDGFVVLRVVPVRAPRRARTVGCLYRHGQWWFYDVTADRTIRPANEIS
                     AAAKEIRTSMETAVAA"
     gene            19211..19513
                     /locus_tag="K2F47_RS37660"
     CDS             19211..19513
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS37660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242911025.1"
                     /transl_table=11
                     /translation="MTEEYPVKRYGLVAQVNGVHADMWMIPRFASILTGVNAARLNRWA
                     AAGLLSYRQDEPRAPRRYLRAELLIVSGLGVNGDPPTIYALRRHIRRVQTTSSDA"
     misc_feature    19430..19432
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19817..20299)
                     /locus_tag="K2F47_RS37665"
     CDS             complement(19817..20299)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009085944.1"
                     /locus_tag="K2F47_RS37665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_242911026.1"
                     /transl_table=11
                     /translation="MKRVLVTGMSGAGKSTLLDELASRGFPAVDTDYGDYLEEIDGERL
                     WREDRIRTLLHDAPVAETGALFVQGTVRNQGLFYPCFDHIVLLSAPVEVLVERLSTRTT
                     NSYGKDPAELAATLEYVETVEPLLRASATLEVVTTVPVREVADIVLAHIGLPSPPV"
     gene            complement(20324..20776)
                     /locus_tag="K2F47_RS37670"
     CDS             complement(20324..20776)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017617698.1"
                     /locus_tag="K2F47_RS37670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_242911027.1"
                     /transl_table=11
                     /translation="MSGYEGLRSSQVAQAAGVNPQTLRYYERRGLIAEPERTLGGHRLY
                     PAETVTLLRVIKTAQRLGFTLDEVAELLETGAHRHQAPDAGLAARARHKLAEVEAKIAD
                     LEAIAGSLREALNAGCDDLIACSSRPRCPLPFPGVDAPSTAPSRLP"
     gene            complement(20773..21174)
                     /locus_tag="K2F47_RS37675"
     CDS             complement(20773..21174)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546177.1"
                     /locus_tag="K2F47_RS37675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_242911028.1"
                     /transl_table=11
                     /translation="MEFKQGKAGSAPAIQDEGWTPAACTLPTAQKPLRVAEFDALFAEA
                     VTAVELVASGRVRMRMRPAPKLAGRAADLAARETECCSFFTFSITATSGELTLEVAAAD
                     EHAPVVAALAERAEQLVQRDGIKPEERFR"
     gene            complement(21231..21599)
                     /locus_tag="K2F47_RS37680"
     CDS             complement(21231..21599)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059363.1"
                     /locus_tag="K2F47_RS37680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_242911029.1"
                     /transl_table=11
                     /translation="MPVTGPDFVSLQARDLDASQAFYERYLGLVRSRTGPPHAVVFETK
                     PIAFALRDIVPGTDLESAARPGIGAAIWLHATDVQAIHDALVADGHTIVSAPIDGPFGR
                     TFTFADPDGYQITLHDRA"
     misc_feature    complement(21603..21618)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.44"
                     /tool="antismash"
     misc_feature    21631..21651
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.64"
                     /tool="antismash"
     gene            21663..22118
                     /locus_tag="K2F47_RS37685"
     CDS             21663..22118
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543176.1"
                     /locus_tag="K2F47_RS37685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_242911030.1"
                     /transl_table=11
                     /translation="MSQDEVVDLRTSLGYLLKEASSALRAAMEEVLRPLGMSITHYACL
                     ELLAQRPGLSNSELARGAFVTRQTMNVLLQALEREGYVTRPAAAPVGKALPARLTPRGR
                     RSLEKASAAVRSVEVRMLDGMTEAERADAFRILQRMIHSLREGNDGA"
ORIGIN
        1 ggggtctacg ggatgaactt cgacttcatg cccgagaccc agtggcgcta cggctatccg
       61 ctgatcctcg ccgtcatcgg cctggcgtgt ctgtccctgt accgcggttt ccgccgcaac
      121 ggctggctgt gattatcgaa gtcccggccc acgtccctcg cctggcggct cgggatgtga
      181 ccgtgccttt gcgggcgcgg catcgcttcg cgatcttccc ggtggggctc gccttcggcg
      241 tcgccccacc gctcagccaa cgcgcccgcg tgacagctga ggtcaccggg gcgcgtgcta
      301 ggcgctgagg gtcagagcgc ggtccgggta gtcggtgacg atcgcgtcca cgccgtactt
      361 ggccaggcgc gacatgtcct cgcgctcgtt gaccgtccag gcgacgacgg cgagcgcggc
      421 cgcgtgggcg tcgtccacca gggacggggt gatcagcgtg tgctcgggcg acagggcggt
      481 cgcgccgatc gccacggcgg cggcgatcgg gtcttccggc gcgagcccgg caagccacgg
      541 ggtgtccggg acgagggtct tgcgctcgac cagcgccacg cggccgagcg ccgggtggcg
      601 gtgggcctcc gcgaggacgc gccagtcgaa gcccagcaca cggctccgat gggtcacgcc
      661 cgcttcgtcc aggacggacg cgaccgccgg cacgaaccgg gcgacgtctt catcaggcca
      721 gctgggatcg gtcttcaact ccaccgacag cagcaccctg gacggctcca gcagcgcaca
      781 agcctcggcg agcgtcggga tcggcgtgcc gggcagcggg agctgcgtcg ccgtgaacat
      841 gtcgtcgcgc tgccggacgc ccgcgtccac ggtcttgagc tgctccagcg tgaggtccct
      901 gatcgccttg ccgacgtagg ggaacgccgg gtcgccggga cgcgcaggcc tcgtgtcgga
      961 gaggttcacc ggcgagagca cctggtcgtg gcagaggacg accacgccgt cggaggtgag
     1021 gccgacgtcg agttcgacgg cgtccacgcc caggtcgagc gcgcacgcga agccggggag
     1081 ggtgttctca ggacgaagcc cccgtgcccc ccgatggccg tggacctcga cggttcgcgt
     1141 cacggctccg cacgctagcg cgggcgcctc gggcccgggt ggagtggagg tgaaaacggc
     1201 aggtcagatc agggaacgga gcgacagcgt ctgctcgcgg ccgggtccga cgccgatcgc
     1261 cgagatctgg gcgcccgaca tttcctccaa cgcccggaca taagcctgtg cggtcttcgg
     1321 caggtcgtcg aacgtcttcg cggccgtgat gtcctccttc cacccgtcca ggtactccag
     1381 gatgggcttg gcgtggtgga agtcggtctg cgtggtcggc atctcctcga cccgctcgcc
     1441 gtcgatctcg taggcgacgc agaccgggac gcgctccagg ccggacagca cgtccagctt
     1501 cgtgaggaag tagtcggtga tcccgttgac ccgggtggcg tagcgggcga tcaccgcgtc
     1561 gaaccagccg cagcggcggt cgcggccggt cgtgacgccg tactcgccgc cggtcttgcg
     1621 caggtactcg ccctgctcgt ccagcagttc ggtggggaag gggccggagc cgacgcgcgt
     1681 cgtgtaggcc ttcagaatcc cgatcacgcg gctgatccgg gtggggccga tgcccgagcc
     1741 cgcgcacgcc ccgcccgccg tcggactgga ggacgtgacg aacgggtagg tgccgtggtc
     1801 gaggtcgagc agcgtgccct gggcgccctc cagcaggacg accttgtcgt cctccagcgc
     1861 cttgttcagc acgagcgagg tgtcggcgac gaacggccgc agccgctccc cgtaggccag
     1921 gtactcctgg acgatcgggt ccgtctcgat ccggcgccgg ttgtagacct tcgtcaggac
     1981 ctggttcttc tcgcgcagcg acaggtcgag cttctggttc aggatgttcg ggtcgaacag
     2041 gtcctggacg cggatgccca tccggttgat cttgtcggcg taggcgggac cgatgccgcg
     2101 cccggtcgtg ccgatcctgg ccttgccgag gtagcgctcg gtgaccttgt ccagggcccg
     2161 gtggtggggc atgatcaggt gcgcgtttcc ggagatcagc agccgttcgc aggtgatccc
     2221 gcggtcccgc aggccgtcga tctcctggag cagcacggcc gggtcgatca cgacgccgtt
     2281 gccgatcacc gggaccacgt cgggggacag caccccggac ggcagcaggt gcagggcata
     2341 gctcttgtcg ccgatgacca cggtgtggcc ggcgttgttg ccaccctggt agcggacgac
     2401 gtagtcgacg tccccgccca gcaagtcggt ggccttgccc ttgccctcat ctccccattg
     2461 ggctccgaca agaacgatgg ccggcatgcc gctgtttcct tcccacgacg aaggccccgg
     2521 tcgccgcaag agcgaagggg cctcttgcga tcaaagcgta cccgcacctg gagccagagg
     2581 aaaacgcacg ccgtccgggg cggcccggag cgaaagcgat cagcccccgg agcgaaagcg
     2641 atcagccccg gagtaaaagc gatcagcccc ggagcggtag cgatcagcgc ccggggcgaa
     2701 agcgatcagt tcccgagggc ctcggcggcc gtggggctgg agtccttgag gaacgtccgg
     2761 cagcgctcgg cctcgtcgtc ctcaccgatc gcggcggcgg cgcgggcgag ggcatgcagg
     2821 gcgcgcagga aaccgcggtt gggctcgtgc tcccacggga cgggcccctg cccccgccag
     2881 cccgcgcggc ggagctggtc gaggccccgg tggtagccgg tgcgcgcgaa cgcgtaggag
     2941 tcgatcacgc cgcccctggc gaaggcgcgg tcggccagtt cggcccacgc ccccgggtag
     3001 tcggggtggc gcgcggccac ctcgaagggg tcgacgtcgt tcgccagggc ctccctggcc
     3061 tcggcgttgt ccggcagttc ggtcggaggc aggccgccga gcaggttgtt cgtcatcggg
     3121 tcatcgtagg tcggcgcgcc tcgtccggcc caatcggctt tccggcgggt ccggtgggaa
     3181 ccctggagcc cttgcgggga cgcggttagg atcgcccaat gctcacgccc ggcggaatcg
     3241 acaccggcgt cccgagcccc gcgcgcgtgt acgactgcct gctcggcggc aaggaccact
     3301 acgagtccga ccgccgggcc gcggcgcggc tcctggagat cgttccaagc atgcggttat
     3361 ccgcgacgca gaaccgcgcc tttctcggac gcgccgtcca gtacctggcg ggcgaggtcg
     3421 gaatacgcca gttcctcgac atcggtaccg gtttgccgac gcaggacaac gtccacgacg
     3481 tggcgcagcg catcgcaccc tcgtcccgca tcgtctacgt ggacaacgac gcggtggtgc
     3541 tcgcccacgc ccgcgcgctg ctcaccagca cgcccgaggg cgcgaccgac tacctggacg
     3601 ccgacctccg cgaccccgac gcgatcctgg agcacgcgtc ccgcacgctg gacctcgacc
     3661 gtcccgtggc gctgctgctg gtggcggtgc tccacttcgt cccggacgcg gacgacccgc
     3721 gcgggatcgt ctccgcgctc ctcgaccggc tcgtccccgg gtcgtacctg gtcatctcgc
     3781 atggcggctc ggacgccgac ccccgcaagg ccgccgaggc caccggcgtg taccggcggc
     3841 acgcgccgga cgcgctgctg tcgctccgca ccgaatccga ggtcgcccgg ttcttcgacg
     3901 gcctcgacct ggtcgaaccg gggctgggct ccatcgcgca ctggcgtccg gcgggcccga
     3961 ttccgtcggc cgagcaggtc ggcatgcacg gcggggtggc ccgcaaaccc taggggcgga
     4021 cgggcagcgg cagctggaaa tgcgcggtgc cgtccacggt ccgcgcgcgt gcggtgggcc
     4081 atccgtgctg gacgaaccgg agcgcgtccc ggttgccggg gatgacgtcc gcctcgaact
     4141 cggtgatgcc gcgccgcgcg gccagctggg cgaggtagcg gacgagcgcg ctgccgacgc
     4201 cccggcgctg ccaggggtcg gtgacgagga cggccaggtc ggcgcaccag ggccgccgcc
     4261 ggtcccggct gtactcggcg acgcccgcga tctcgtccgc gtccagcgcg atcagggcct
     4321 cgcggtccca gtggtcgagc cgctccagca ggcggacgta gtggtcgggg atgtgcggcg
     4381 tgccggagaa gaaccgcgtg tagaggctgg ccttggagag ccgctccgac atccggcgca
     4441 gccggggccc gtcggtgatc ccgtacggac ggatccggac gtcctccagc gcgggcggag
     4501 gaaggtgggc gaccgtccgc acagtgagtc tcgtcatgca acccattgga ccgcatcaag
     4561 ttttgtgaag caactgacga tttcagcgac cggcccccgg acggggttcc acgtcggtcg
     4621 gcccgagcga cgcgccgcag gcgtcgcagg tgaagctcgc cgtgagcgtc cccgggcagc
     4681 cgcgatggcc cacgagcgtc ggcgggccgt ccggtgcgta gtggcggtcg ccccacagca
     4741 acagggacat catcgccggc cacagttcga cgcccttgcg ggtgaggcgg tactcgaagc
     4801 gctcgggacg gtcctggtag gggacgcggc gcatgatgcc ctcgtcgcac agccgcgaca
     4861 ggcggtcggt gaggacgttg cgggccacgc ccagcacgtc ctggaagtcg tcgaaccggc
     4921 ggacgccctc gaacgcggtc cggatcacca gcatcgtcca gcggtcgccg acgacttcga
     4981 gggagcgggc gatcgagcag ttctgtgact cataggtacg gggcagtgcc acgctgcgag
     5041 gctacccggc cgtaagggaa aacggcgggg ccgccggtgc gcggccccgc cgggacgtca
     5101 cttcagccgc ttgcccgccg acagcaggtg ctcggtcgcc tggacgacgc gcgccgccat
     5161 cgccgcctcg gccgccttgc cccacgagcg cgggtcgtac tgcttcttgt tgccgacctc
     5221 gccgtccacc ttcaggacgc cgtcgtagtt gcgcagcatg tggtcggcca ccggacgcgt
     5281 gaacgcgtac tgggtgtcgg tgtcgatgtt catcttcacg acgccgtagg acaccgcctc
     5341 ccggatctcc tccagcgtgg agccggaacc gccgtggaag accaggtcga acggcttgtc
     5401 cttgccgtac ttctcgccga ccgcgtcctg gatgcccttg agcacctcgg gccggagctt
     5461 gaccgagccc ggcttgtaga cgccgtgcac gttcccgaac gtcgcggcga ggatgtagcg
     5521 gccgcgctcg ccgacgccga cggcctcggc ggtcgcgagc gcgtcgcccg gcgtcgtgta
     5581 gagcttctcg ttgatctcgt tggcgacgcc gtcctcctca ccgccgacga cgccgatctc
     5641 catctccatg atgatccgcg ccttcgcgca ctggtcgagc agctcggcgg cgatctggag
     5701 gttctcctcc agcggcacgg ccgaaccgtc ccacatgtgc gactggaaca gcggctcctc
     5761 accgcgcgcc acccgctcct gcgagatctt gaccagcggc cgcatgaagc cgtccagctt
     5821 gtccttcggg cagtggtcgg tgtgcagggc gatgttcacc gggtacttgg cggcgaccac
     5881 gcgggcgtac tcggcgaggg cgctcgcgcc ggtgaccatg tccttcaccg tggcgccgga
     5941 gaggtattcg gctccccccg tggacacctg gacgataccg tcgctctccg cctcggcgaa
     6001 gccgcggagc gcggcgttca gcgtctggct ggacgtcacg ttgatggcgg gataggcgaa
     6061 gccgtcctgc ttcgctcggt cgagcatctc cgcgtagacc tcgggcgttg cgatgggcat
     6121 tgtcagcgtc ctttcttacg cagggtgccg ccggcatccg gccgggcggt agcacccgtc
     6181 caccgcgtac ccagtcgatt cgcctggtca cgcggttccg ggcagtgcgt tccgtccacg
     6241 gtcagtatct cgtcggggcg ctcgcccact ccagaggggc ccgcgaggtg ccccaagtat
     6301 ccaggattcc ggcgtccggt cgaggggttt gcgagggtgc gtccggcgcg atccccagca
     6361 tgagaacgac tcgaacaccc ccggaacagg ccggtttcgc gctcacgaag agcgccggga
     6421 caggtacgct cgcaatgtgg atctcacgac ccttcccctg gacatcaccg agtacctgca
     6481 tccgacggcc tggttgcagc tcttcggcac gtttgcgacg atcggcgtcc tcgccatcat
     6541 cttcgcggag acagggctgc tgatcggctg catcctgccg ggcgactcgc tgctgttcac
     6601 ggccgggatc ctcacggcgg tctcgaccgt caacggccag gagttccagt cgctgtcgct
     6661 gccctggctg ctggtcggcg gcccggtggc ggcgatcgcc ggcgcgcagc tcgggcactg
     6721 gctcggcgcg cgctacggcc gcaagctctt cgaacggccc gactccaaga tcttccggca
     6781 ggagtgggtg gagaaggccg agtactactt caaccggttc ggccccgcga aggcggtcgt
     6841 gctggcccgg ttcgtcccca tcgtccggac gttcctcaac ccgctcgccg ggatgctcgg
     6901 catggacgcc cgcaagttct tcatctggaa cgtcgtcggc ggcgtcgtct ggaccgacgc
     6961 gttgttcctg ctcgggcact tcctcggctc cgaggtcccc gacgtcgagc gctacatcct
     7021 gcccggcgtc gccgtgatcc tcgtgctgtc ggtcatcccg atcatccgcg aggtcatgaa
     7081 gggccggaag gcctcgcgcg ggggcggcaa gcactcgcgt ccgaagaata atggccccga
     7141 agagtctcgt ccgtcgctca gcggtgacag ttatcgctaa cctccccatg tgggacgtca
     7201 tcggtcggac cctcgtggtc tcgcgcgcat actgatcgcg gtcgtagccg tggtcgccgc
     7261 cctgggtctt cttgtcgccg gcggcctctc cctggtgaac gcggtctcgg gcgactccga
     7321 caaccacgat cccgcgaccg tctccccgtc cccgggcgac ggcggccaga acaagtccgc
     7381 gccgagccgc agcccgtcct cctcgtcctc gggtgcgctg cccctcgtga tccgggtgac
     7441 cggcccggcc acgaacgtcc tcgtccgcgt cgccgacacc ggcgaggtcc tcacccaggc
     7501 cctgctgtcc accggcgaca cccgcaagta cgagcagacc cccctccagg tcgtcgccac
     7561 gaacggcggc tccctggagg tggtgatcta cggcaggaag tggcccgcca agccgtccgg
     7621 cacgcggggc cagtggttcg tctccgccag gaagtgacgg gaggccgggg agggaccggt
     7681 cgcgatcagg agatctccca cgcctggtcc ctgccgttga cgcactgcca gttcacgacc
     7741 gcgcccccgc ccgcgaagtt cgcgccgacg acggtgaggc agttcgcgtt gaccccgctg
     7801 accaggttgt cgcccctgaa gtgccactgc tgcccggccg cgccgttgca gtcgtagagg
     7861 ttggtggcgg ccccgctgcc gccgtttccg ccgcggacgt ccaggcactt gttgccgggc
     7921 aggtcgcttc tgagccgccc gccgtcgaac gaccaccgct ggttggcgcc gccgtggcag
     7981 ggccagaccg tggtcagggc gccgttgccg gtgttgccgt ccgcgacctc aaggcacagg
     8041 ccaccggcgg cccggggctt gacgaggaag ccggtgagct tcttctctgg cttgggcgcg
     8101 ggcgccgccg aggcggacga gggggccgag gccgacgagc cggcccacag cgcgcccgcc
     8161 atggtgacgg ccggcagcag cgcgagaatc gagaaggtgc gcatcgtgct ctccagttcg
     8221 atggttgcgg gtccgccgga tcggtggtcc ctgtcgcctc aacgttcgcg ccggcactgg
     8281 tgggcggcca tccccagatc ctgggatgga caacgcgtgc ttgtccgcat gcggcgcgtg
     8341 gtcgatactg ggcggggtga gcgctggacg gagcgcgccc ggcgccgcac tggtcggcgc
     8401 cgccacggag gtcggctcgg ccaccgaact gggtgcggtg atctcacggt gggtcggacg
     8461 cgcggtaccg cacgagggct acatgctcgc cgcggtcgac cccgtcaccg gcgccgggtg
     8521 cttcctggcg cgcgggcacg gctacacgac ggcggccgcg cggcagttga ccctgggtga
     8581 gcgcctgaac tgcgaccacc cgtttccctt ccagcgcctg gtggcgggtc cgtgccatgt
     8641 gggcgtcctc aacaccgacg gccccgtgcg gcgccgcagc cccacgatgc gcgcggtgat
     8701 ggccgacctg ggcgtgggca gcgaactccg cctcgcgctg gtcgacggcg ggacgacctg
     8761 gggcggcctg gtcctgctcc gtcccagggg agcccgcccc ttctcgccgg acgaggcgtc
     8821 ccgcgcccag cacctggccc gcgacatcgt cgccgcgctg cgccgctatg cgacgggcgt
     8881 gcccccagaa ccgaacaggc tcggcgcgcc accgggcgtg ctggtcctcg gcgccgacga
     8941 gacgatcctg tccgcgaccc cctccgcacg catctggatt cgcgaactcg aaacgcttcc
     9001 tgccgccgcg ttggccgcgc cggatttgcc gatggaaagc accatctggc acctcaccca
     9061 gagcgtccgc ggcccggagg agccgacgcc gacccgcggc ccgggcatgc cggggctgac
     9121 ccgcgtcccc accccgcgcg gctggatcgc catacgagcc cagcccatgc ccaccggcgc
     9181 gatcgccgtg acaattcagg cggccgccgg taaggaactg ctttcggcgg tggcactctg
     9241 gcagggcctc agcccgagag aacgcgtggt catcgaccac gtcctcgaag ggctatcgag
     9301 caagcaaatc gcccgccgcc tgcacgtgtc gcctcacacc ctcaatgacc acctgaaatc
     9361 catttaccgc aaagcgggcg tctccacccg cgaagaactc ctgtcgcgct tcctcaactg
     9421 actcccgggc aggcggtact cctgccgccg gtggggtgac tctggcggcg ccgccagacc
     9481 ccgtccaccc ctgtgacctg cgaatcggcc accagcaagg ggtggcgcga cggtggcgag
     9541 gtctccctac cccgaacacc cattcattac tgtccgtagc gatatataca ctgtgagcga
     9601 atgtcgggtt ctatgttgct cacccctgac cgtccgcttc aggggaggag gtgaaccgac
     9661 atgagcatgg cttacgagcc gccgtccctc gtagtgatcg gcgatctgcg cgagatcacc
     9721 cttggagaca ggtcctgggg attcgaccgc atcaaccagt gcgccatgtg gaactgctga
     9781 cagtccactc gtgattcccc ggtcggccca tgctgccggg ggagggccgt gccggtcgtc
     9841 aaagaccggc acggccggcg cccatctttc gaagcgcccg gcatcgaaca ccgccgggcc
     9901 cggctttcgc gcgggacgaa atcacggtga gccgtcccgc tcgctggggg aaggcatgcg
     9961 gttcttcgtg gttcccgaca attccgaggg tgccttggtc gtggcgtcct tgcatacccg
    10021 gtggcccgac ctgcggatgc tgccgcacga ttcgggacgt ccgtggatcg tgggccactg
    10081 gcaggacgag gaggtccgct gggccgcggc aggaggacgg cgtatcgcgc tgctgggacg
    10141 ggtccaggtg agcgtgccat ggctgaccag gtacatcgtc gggcaacctg agccgggcgc
    10201 cctggcggat ctgagccgcg agctgcccgg cagctaccac acggtcgccg cgatggaccg
    10261 cgtcgtgttc gtccagggag acctttcgac ggtgcgggag gtctttcacg gccaggtgct
    10321 gggagtgacg atcgcggccg accgtcccga cgggctcgcc gagctggcgg acgcggcgat
    10381 cgccgaagag gaactggccg tccggctgct cgcccccgcc gtgccgtggc cgctgagcga
    10441 ggagtgcctg tggaagggga tacaggcgct tccctccggc tgccacctgc ggatcgggcc
    10501 cgacggtcgc ggccgggtga cgcacggccg gtcgcttccg gcgcccgagc taccgctcgc
    10561 cgaaggggcg cgccgggtgc ggcacgcgct aaaggaggcg gtgcgggtcc ggacgcacgg
    10621 ccaggcgatg ctgagcgccg acctgtccgg tggaatggac tccaccagcg tgtgcttcct
    10681 ggcggccggc cgggtcgatc ggctgctgac ggtcgtctgc gagcccggtg acccgtccag
    10741 cgatgacggc cgctgggccg cgctcgccgc gacgtccctg cccggcgccg agcacatgtc
    10801 ctaccgtgcg gaggactgcc cgcgctactt cgccgggctg ctcgacaccg accccgatct
    10861 ggaggcgccg cttccgtccg tccacgcgcg ggcgatggtg ctggagcagg cgcgcctgat
    10921 ggcggcggcc ggttcgtccc ggcatctgac cggccacggc ggcgacgagt tgttccttcc
    10981 cacccccgcc tacctgcacg acctgctgcg cagacggccg ctgcgggcga tcgggcagct
    11041 gcgcgccgga cgggcggtgt cccgctggca gacccgtccc accgtcgccg cactactgga
    11101 ccgcacctcg ttcgccgact ggctgggcca cgagatcggc cgcgacctgc ggaacccgat
    11161 ccggggggtc ggcaccgccc cgctgtcggg ctggggcccg gcctaccgga tgcccgcctg
    11221 ggccacgccc gaggcggtgc gctcagttca gcatcgattg cgggaggtgg cgcgggcgcg
    11281 cccgtccccg ctgtcgccgc tgcgcggccg gcacctgacc gtccagcaca tccgccaggg
    11341 cggtgagctg gtgcgccgta tcgaccgcct ttcgctccag cacggcgtca ccaccgaggc
    11401 gcccttcctg gacgatcagg tggtcgaggc ggccctcgcc gtggactacg ccgactgcct
    11461 gcgggccgac cggtacaaac ccgtgctggt cgaggcgatg cgcggcatcg tcccgagccg
    11521 cagcctcgga cggcgctcca aggccgagtt cagcgcggat ctctacaccg ggctccgcga
    11581 gcaccgccac gacctgctgg aactgtgcga cgggatgcgc ctggcctcgc tcggcctggt
    11641 cgatgccgcg gcgctgcgcg ccgtcatcct gagcccgccg ccggtctcgc tggaactgct
    11701 gcccctgctc aacaccttcg cctgtgaggt gtggctgcgc tcggtcggca ccggacgtcc
    11761 acgctcacgc gccgcttcgg aggcgggccg atgaagatat gccccgatgt gaccctcacc
    11821 gacaccggcc agggcctggt gctgctcaac gagcggaccg gccgctactg gtccctcaac
    11881 ggcaccggcc gagccgtgct gctcatgctc gcggacggag ccacgcccga agaggcggtg
    11941 gacagcctga cgcggcagca ccccgacttc gccgaccgga tcacctcgga cgtggaggcg
    12001 ctgatcaaat cgctcctggc agagaaggtg ctgctcccat gacgatgccc gtcgccctcg
    12061 aaccgcgacc ggacgtctcc cgcggccgcc gggcggccgc cctcgcggcc gtgtccgcgg
    12121 cgacgctgct ggagcggctg ccgccacgcc ggttgcggcg cgtcctggag gcggctcgcc
    12181 gcggagcccg cccggccacc gccgcgcagg cgctggccgc gcgcgaggcg gtcgtggcgg
    12241 tcagcctcca ctgcgccggg cagggctgcc tgcggcgatc ggtggccgtc gcgctgctgt
    12301 gccggatggg cgggtcctgg ccggactggt gcaccggcgt ccgcgtcgag ccgttccgcg
    12361 cgcacgcctg ggtcgaggtg gacggcaccg cgatcgggga gctggacgac atgcacctct
    12421 accacaagac catgacggtg cccgcccggc gccggggcgg gcggtgagca tgcgcgaggc
    12481 gttcgcgctg gccgcccaga gtctgacggc cgggatcttc gccgtcgccg cgttcagcaa
    12541 actgcggggc cgggaggatt tcgagcggtt cgccaccacc gtccgcaagc tgacgatgcg
    12601 ctcgggtccg gagaccaccg tgctcgccgg ggccttcgcg gtcgtcgagg ccctgaccgc
    12661 cgtgctgatc gccgtgcccg ccaccgccac cgcgggcctg tggacggcag cggcgctcct
    12721 cattctgttc atcggcgtgg tcttccgggc cgtccgcggc aaggtgttcg ccgaatgcgg
    12781 ctgcttcggc ggcagcgcga tcatgagcta ccccctactg ctgcgcaacc tcctgctcct
    12841 ggccctggcg ctggcgggtc tggctgcccc ggcctgggag ggcctcgccg tccgcggcgc
    12901 cgcgctggcc gccggcctgg tcgccgcgcc ggtgctgctg cgctcctacg accgcgccgt
    12961 gaccctcgtc ctcggacggg tgcacgccag gacccagccg tgaccgcgcc gatcgaggtc
    13021 cgcgggctga gcaagcactt cggccgcgtg atcgcgctcg acgccgtcga cctcaccgtg
    13081 cccaggggag ccgtccacgg cctgctgggc cacaacggcg ccggtaagag caccctggtc
    13141 ggcgtcctcg cgaccctgct gcgccccacc cggggcaccg tccgcgtggc gggccatgac
    13201 gtgctcgaac gtcccgccca ggtccgccgc cgcatcgccc tcaccggcca gcagacgacg
    13261 ctggacctca caatgtccgg gcgcgacaac ctgttcatga ccgcccgcct gctcggcgcc
    13321 ggacgccgcg ccgcccgcgc ccggaccgac cagctgctgg aggcgttcga gttgaccgcc
    13381 gccgccgacc gtcccgcccg cggctactcc ggcggcatgc ggcgccgcct cgacctggcg
    13441 atgaccctcg tccggcgcag cgaggtcgtc ttcctggacg agcccggcac cggcctggac
    13501 ccggccagcc gcctcgccac ctgggacatg gtgcgcgggc tcaccgccac cggcagcacc
    13561 gtcgtcctga ccacccagca cctggaggag gccgaccgcc tcgcggacgc gatcaccgtc
    13621 ctcgccgacg gccgcgtcgt cgccaccggc ccgcccgagg acctcaaacg ccgcatcggc
    13681 cgccgcagcg cgacggtccg cctcgccacg gccgccgaca cgctcgccgc cgaccgcgcc
    13741 ctgaccgccg cgggcctgcc ccccgagtgc gaccgccccc gccgcgccct gaccatcacc
    13801 ctgacccgcg accgcgacct caccgccgtc gtccgcgtcc tggacgcggc cgggatcgaa
    13861 cccacccgcc tgaccctgtc cgaaccaggc ctggaccagg tgtacctggc cctgaccggc
    13921 caccgccgaa cggaagcacc atgaccgccc cgcccctcac cgaccacccc cacgagccgc
    13981 tcacaggctc cgacgactgg cacggcgcgg caacgacgac ccagatcgcg atactgacgg
    14041 cccgctccat gcgcgccctc gtcctggacc gccgcctgct gatcatcggc gtggtcgaat
    14101 ccctcataat gctgatcgcc ttcggccagg tcttctccgg cctcgcctac gccccgggct
    14161 tccccgccca catcaaatac atcgatttcc tcttcccggc cctcatgctc accacaacgc
    14221 tgcaaagcgg catccaggcc ggaatcggag tcaccgacga cgcccagtcg ggcatcctcg
    14281 accgcctccg ctcgatgccg gtctggcccg gctcgatcct catagcccgc agcctcgccg
    14341 gcctggcccg aggcgccctg cgcctactcg tcctcctgac cctggcccgc gccctgttcg
    14401 gctaccaccc cgcaggcggc gtcgaaggcc tgctggccgc cgccgccctc tccctggcgg
    14461 tgagctggag cctgagctgg ctcttcatcg ccctggcctg ctggatccac cagtccgaag
    14521 ccctccacgc caccgcgggc ctggtgatgt tcccgctgat gtacgcctcg aacgccttcg
    14581 tcccgatgga cggcctcccc ggctggctcc gctggatcgc ccgctacaac cccataaccc
    14641 acggcatcaa ctccgcccga gacctatgcc taacaggcac cacgggcccc ggcgtcctaa
    14701 ccgccatcct cgcaagcctg ctaatcgcca ccgcagccgc caccacagcc accaaagccc
    14761 tctcccgccc ccgctaaccc caacaaccca agcccccacc ctcacccccc gcagcccaag
    14821 cgcccgcccc cctccacaat caggcaggag ccgaggagga tgagggcccc tgcacgtcgc
    14881 ctggacgctg gcagaagcca agttgcgaac cctgcggggc gatgaggacc agggcttgcg
    14941 tacgtccgca tcaccaccgc caaggtgttg cgaaccctcg caggggcgat gacgaggctc
    15001 ctgcctgacc tccgcccgac agcaggaccg ccgcgttgcg aaccttcgta ggggcgatga
    15061 ggacgccgac gggctcggca tggcgcaccg ctgcaccgct cggttgcgaa cccccgtggg
    15121 gctatgagga cgcagcgact cctgctggcc accactaccg ccggggcgtt gcgaaccttg
    15181 gtgggggcta cgaggagccc atagtagagc cgctggctgg atgacacgtg tgcttgcacc
    15241 agaccaccgg aggcggaacg aaccgtgccc acgttgaccc tcccgttgcc gtccggcggt
    15301 acctggacgc gggcagatta tgaggcgctg cccgaagacc ttccggtacg cgtgagcctc
    15361 atccatggag cgctggtggt ggccccccgg ccccgcccgc tccaccagcg catcgcccgg
    15421 cgtctggcga ctcgtctcga agacgcggcc cccgatgcct ggcaggtcga caccgccgtg
    15481 gacgtcctcc tggacgacga tgaagtggag gcggtcgaga tcgctcccga catcgtcgtg
    15541 tactccagcg accacgaccc ctacgagcgc ccgattctcg cccatcaggt cgccctggtt
    15601 gtcgaggtcg tctcaccgtc gaccaggcac agggaccgcc gagtgcaacc agccttgtac
    15661 gccgaggcgg gtatccggca ctactggcgg gtggagaccg accagaccgc accggcgttc
    15721 gccgtctaca cctacgaact gggcgatgcc accggcggat acgtcgcgac aggcgtacac
    15781 cacgaccgga tcaccgccac cttgcccttc gccctcgaca tagaactcaa ggccgtccgc
    15841 gaacgctgac atccgcgacg taccgctcaa caacccgagc ggtaatggct gggtgcaggc
    15901 ggcttctggc ttatctggga ctggttttgt gatcccctcg caggggcgat gaggacgcgc
    15961 ggcgccgctg cgcccgacga cgcggaggct gttgcgaacc cgcgtggggg cgatgaggac
    16021 tggacgatct agtgcagatc ctggacgtgc tgctgcagtt gcgaaccctt gtaggggcga
    16081 tgaggacgac ctctgatgaa ccgcggcacg gtgctcatcc tcacgttgcg aacccttgta
    16141 ggggcgatga ggacacgttc cagggctaca tggcggtgtg tgtcagtttg ttgcgaaccc
    16201 ttgtaggggc gatgaggacc ccatggtaaa gccgctggct ggatgccacg gcgacagccg
    16261 tacatggagt gcgatttcag cgagcctccg gtagtgcacg cgaccccggc gtgtcgctga
    16321 aacgatcaag gttgacctgg cagcggacac ggctaccgca tctcagcgag gcgcggtcgc
    16381 ttgttccttc ttggggtggg cctcccgaag ggaggggaag cgcggggcgg tggacccggc
    16441 cgtacgcccg ccgtctcggg ctggcctcgg tggccggtta aaggtcgagg ttcccagcct
    16501 ttgctcgcga tacgagcacg gtgaacgcgg tgcggtcgat ggccaggtgg ccgctgtgcg
    16561 ggttcttgct gtccctaata ctcaggaggg tggcggttct cgcgacctcc acacactggc
    16621 cggagctgcc gccgctgtag ctgctcttgc gccactggac ggacgtcgtg ctggtgatct
    16681 tcacggttcc tccatggggt gttggtcggt ctcggcttgg tgattggcga gttcccagag
    16741 gctggcgacg tgggaggcga accggtcgta gaggccgtcg tcctgaagtc gtttaatgtg
    16801 cagcatcggg gagtcgtgcc cgaccaggcg cgcgaggtgc ggtgtgacga gcatctggtc
    16861 gtcaaagaca aatgcgctca gtccgatgtg ctcgtcgccg tagcgcgttt cgatggtcgg
    16921 gacgtcgctg agcttggaca actcgtccat cgtgacttgg atgcgagtgc tgacggtcag
    16981 cgggaccgcc tccagctctt ctctgcgacg tgtgacctca ctgttcgggt cgccgatgag
    17041 aaagcggatg cggcaacccg cctctgcctg cctgcgcagg acgctgcgta ggttgggcaa
    17101 ctccagccat aggaagtagt tggtgtatcc cgcgaaggtc agttctgatt tcgcattgct
    17161 gatcagcccg cgccacaccg atttcgggca gcttgaccgg tacggataaa cggcgacgat
    17221 ctcgcggtcg gcgccgatct tgatgttcct gccgacggtt ttgggccaga gcacggcctc
    17281 accaactccc ggtgcctctt gctcggctct accagtgtgc caagcgaaag gccccggcgg
    17341 gagggaggtc ccgccggggc cgatcgaggg tcggtcacag gttgaggtct ccggccttca
    17401 ctcgccacac cagcgcggcg aacgcggggc ggccgatgga caggtgacca ccttcggggt
    17461 tcttgctgtc cctgattccc acaagcgcgt aggtctccgc gacctccaca cactggccac
    17521 tctgcccacc gctgtaactg ctcttgcgcc aggggccgga cgtaagcttg tcggtcgtct
    17581 tcacagttcc tccaacgctt tacggatggc ggccgtcgac tcctcagcgt tcaacgcctt
    17641 ggacctgatc aactcaaaca gtatgccaag ttcggcgacg taatcgcctt cgtcgatcag
    17701 acggccgcgc ccaccggcgg actctgcgta gacggtgtcc ggctccccag gggagcacag
    17761 gatcgtgaac gtaccctctg gagacagttc ggcgtcctcg gggacgatgt ggatatgcac
    17821 gtgcggcagg tcagccaacg tgagcagatg ctcgagctgt gcgcgcatga cctcgcgacc
    17881 gccgaagggg cgacggagca cagaggcgtc tagcaacgca aagatggctg ggggctcatc
    17941 cgcgttgatg atctcctgac gttcgagtcg ggccgtgacg agactttcca gcttgttcgg
    18001 ctgctggccg gccttcagca cggcgcgagc gtagtcaggc gcctggaaga gacctgtgat
    18061 cacgaagttc tcataaacct tgatcatgcc tgcctagccc tccgcgtctg cgaactcggg
    18121 gaatcccgct gggaggccgg tctcttcgag gacgcggggg tagagcgggg tgaagaactg
    18181 gtcctgctcg aacgcccggt cgagggcctg gcagttcctg cgggtggggc ggcgctgctg
    18241 ggtctccatg ccgctgatca ggcttcccga gacgtggatc ttgctgccaa gcgtgggctg
    18301 tgaccagccc ttttcctcgc ggaggcgctt gaggtggtac gcgaggtatg cacgagccga
    18361 ttccgacggg tcgatcgacg gcatgggggc ctccctgatc cggcacgtga cgctgtgctt
    18421 gggctcagtc gcttgtggag agctttgtat agcgcagagt agccgcgaga acacaccatc
    18481 ggaggccaga cagcgaaatc ggtggctcag gagacagatc atgtgcatcg acgacacggc
    18541 gggacgaaca tcgcagccgg gcgaaccggg gtacgagcgg gaagtttcct ggcttgagga
    18601 tgtggtgagg gcgctcgaca tggtcggggg cttcaagacg tccatgcggc agctttacgg
    18661 cgacggggcc ccgtttctgg acgtcgtggg tgacggggga gcgcggctca aggagaccgt
    18721 ccacgtccgg tgggtcggtc agagcctgcg gggcgtctgg tcgtggggcg aggacatcgc
    18781 gggcgacggg gatccgcagg tggcggccga ggcgatcggc agggtcgtca gccccaggat
    18841 gtgacccggt catgggacgc catgagaaga ccccgggaaa ccaccctcag cccccgagcg
    18901 aggtggagca ggagggcggg cccgcgacct tcattccgca gagcgagcgg gtcacgtttc
    18961 tggtccacct ggctcgggag ttcgaggacg cggccgggtt gatgaccgtg ttcgccgttc
    19021 tcgacggatt cgtggtcctg cgtgtagttc ccgtgcgggc accccgccga gcgaggacgg
    19081 tcggctgcct ctaccggcac ggccagtggt ggttctacga cgtcacggca gaccggacca
    19141 tccgtcctgc caatgaaatc agcgcagcgg caaaggagat caggacgagc atggaaacgg
    19201 cggtggcggc atgaccgagg agtatccggt caagagatac gggctggtgg cgcaggtcaa
    19261 cggcgtccac gcggatatgt ggatgattcc caggttcgcg tccatcctga ccggcgtgaa
    19321 cgcggcgcgg ctgaaccggt gggctgccgc cgggctgctg tcctaccggc aggacgagcc
    19381 gcgtgctccc cggcggtatc tcagggcgga actgctgatc gtgtccggat taggcgtcaa
    19441 cggagaccct ccgacgatct acgcgctgcg ccgccacatt cgccgcgtcc agacgacgtc
    19501 gtccgacgca taaagctgcc cgccgtggac aagattcgtc cggcgggcac ggggtcccgg
    19561 agccgatgtg actggggaag cggtccggga ccccatccat ccccgggcgg gggccgcctc
    19621 gaacaccccc gcccaactcg tcggcctacc tgcggcgggc gccggggagg cgaggggttg
    19681 ggggtgcggt cgcggggcgg ccgagtgggg cgcggacggt gcccaggctg cggacgccag
    19741 gcagcccggc cggcatccgg tacggcgcgc cgcgcgtcct ataggtccgg caccggcctc
    19801 gtggttacat cgcccgtcac accggtggcg atggcaatcc gatgtgcgcc aggacgatgt
    19861 cggcgacttc gcgcacggga acggtcgtca ccacttccag cgtggccgag gcccgcagca
    19921 ggggttccac cgtctcgacg tattcaaggg tggcggcgag ctcggccggg tccttgccgt
    19981 aggagttggt agtgcgggtc gaaagccgct cgaccagtac ctctaccggg gcgctgagta
    20041 gcacgatgtg gtcgaagcac ggatagaaca agccctgatt gcggaccgtg ccctgcacga
    20101 acagcgcgcc cgtctctgct acgggagcgt cgtgcagcag cgtccggatc cggtcctcgc
    20161 gccacagtcg ttcaccgtcg atttcctcga gatagtcgcc gtagtcggtg tccactgccg
    20221 ggaagccgcg cgacgcgagt tcgtccagca gcgtggactt accggccccc gacatacctg
    20281 tcaccaacac ccgcttcatg ccgccggagc atacgtggcg gttctatggc agccggcttg
    20341 gagcagtgga cggcgcgtcc acgccgggga acggcagcgg gcaccggggt cggcttgagc
    20401 aggcgatcag gtcatcgcag cccgcgttca gtgcctcgcg caggctgccc gcgatggcct
    20461 ccaggtcagc gatcttggct tcgacctcgg ccagcttgtg ccgcgcccgt gcggcgagac
    20521 cggcgtccgg ggcctggtgg cggtgggcgc cggtctccag cagttcggcg acctcgtcca
    20581 gcgtgaatcc cagccgctgc gctgttttga tcactcgcag cagcgtcacc gtctcggcag
    20641 ggtagagccg gtggccgccc agggtccgct ccggttcggc gatcaacccc cgccgctcgt
    20701 agtagcgcaa agtctgcggg ttcaccccgg ctgcctgggc gacctggctg gagcggagcc
    20761 cctcgtatcc gctcaccgga accgttcctc cggcttgatg ccatctctct ggacgagttg
    20821 ctccgcccgc tcggcgagcg ccgccacgac cggcgcgtgc tcgtcggcgg cggcgacctc
    20881 cagggtcagt tcgccgctgg tcgcggttat cgagaaggtg aagaacgagc agcattcggt
    20941 ctcgcgggcc gccaggtcgg ccgcgcgtcc ggccaatttt ggggcgggcc gcatacgcat
    21001 ccgcacccgt cccgacgcga ccagctccac ggcggtgacc gcctcggcga acaatgcgtc
    21061 gaactcggcg acccgcaatg gcttctgggc cgtgggcagt gtgcatgccg ccggggtcca
    21121 gccctcgtcc tgaattgccg gagccgaacc ggcctttccc tgcttgaact ccatgaaccg
    21181 acggtaagcc tgtaccccgg taccggctgc aatccccggg caagctccgg tcaggcgcgg
    21241 tcgtggaggg tgatctggta gccgtcgggg tcggcgaagg tgaacgtccg gccgaagggc
    21301 ccgtcgatcg gcgcggagac gatggtgtga ccgtccgcga ccagggcgtc gtgaatggct
    21361 tggacgtctg tggcgtggag ccagatcgcg gcgccgatgc cgggccgggc ggcggattcg
    21421 agatcggtgc cgggaacgat gtcgcgcagt gcgaacgcga tcggcttcgt ctcgaagacg
    21481 acggcgtgcg gaggcccggt ccgcgaccgg acgaggccga ggtatcgctc gtagaacgcc
    21541 tgcgaggcgt cgaggtcgcg cgcctggagc gagacgaagt cggggccggt gacgggcatg
    21601 gtgatgctcc ttatcattat gtcagctttc tgacacaaca cacgctatgt cagaatgctg
    21661 acatgagtca agacgaggtc gtcgacctgc ggacgtccct gggctacctg ctgaaagagg
    21721 cgtcgagcgc gctccgcgcg gccatggagg aggtgctgcg gccgctcggg atgagcatca
    21781 cgcactacgc ctgcctcgaa ttgctggccc agcgaccggg cctgtcgaac tccgagctcg
    21841 cgcggggcgc gttcgtgacc cggcagacga tgaacgtgct gctccaggcc ctggaacgag
    21901 agggctacgt gaccaggccc gcggcggcgc ccgtcgggaa ggcccttccc gcgcggctca
    21961 cgcctcgcgg gcggcggagc cttgagaagg cgtccgcggc ggtccggtcc gtcgaggtca
    22021 gaatgctgga cggcatgacc gaggccgagc gggcggacgc gttccggatt ttgcagagga
    22081 tgatccactc gctgcgcgaa ggcaacgacg gcgcatagct cgtgctccga gtgggggagg
    22141 atggcctgac tgatcggtcg gcgggtgggg ttgagcgtga agcacgacgt gtcggagcag
    22201 ggtgagtcgc cgttcgcggt tgatctgacc gcacgcgcgc gggccgggca ggtgggaccg
    22261 gtcgtcggac gggaggcgga ggtcaggcgg ctgatcgaga tcctcgtccg gcgtgaccgc
    22321 gcgaatccgc tggtggtcgg ggagcggggg gtcggtaaga cgtcggtgat cgagggactc
    22381 gcgctgcgca tcgcgagcgg ggacgtcccg gcggggttgc gggacgtgcg gctgctcgtg
    22441 ttcgatctcg cggcgatcgg ggcggtg
//
