LOCUS       NZ_JAICDG010000007     12118 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinomadura terrae strain OS3-83 contig7, whole genome shotgun
            sequence.
ACCESSION   NZ_JAICDG010000007
VERSION     NZ_JAICDG010000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura terrae
  ORGANISM  Actinomadura terrae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 453487)
  AUTHORS   Lee,S.D., Yang,H.L., Kim,I.S., Choe,H. and Kim,J.S.
  TITLE     Actinomadura terrae sp. nov. and Actinomadura litoris OS3-89,
            isolated from rhizosphere soil of cactus
  JOURNAL   Int J Syst Evol Microbiol 73 (1) (2023)
   PUBMED   36748505
REFERENCE   2  (bases 1 to 453487)
  AUTHORS   Lee,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2022) Institute of Jeju Microbial Resources, BioPS
            Co., Ltd., Sancheondan Dongil 16, Jeju 63243, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 141x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022751215.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:12:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,085
            CDSs (total)                      :: 8,002
            Genes (coding)                    :: 7,936
            CDSs (with protein)               :: 7,936
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 2, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 13 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 3 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 334377
            Orig. end                         :: 346495
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAICDG010000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12118
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12118
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12118
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7118](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7118
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    662..676
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.79"
                     /tool="antismash"
     misc_feature    complement(934..949)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     misc_feature    1065..1078
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.75"
                     /tool="antismash"
     misc_feature    1239..1253
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    complement(1751..1764)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.16"
                     /tool="antismash"
     misc_feature    complement(1875..1890)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.8"
                     /tool="antismash"
     gene            1884..3005
                     /locus_tag="K2F47_RS35610"
     CDS             1884..3005
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS35610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242910570.1"
                     /transl_table=11
                     /translation="MHIAVRHMFVPLTVGAVAFTGLTVPAQAASHPSAVRAARWQATQL
                     DAKGGIFNDQFNFTDWGLTADTVIALKATGVKPQIAKKSTAYIAAHVRSYNSLDDSGQP
                     GVRFSGPTGKLLYLATATKSNPRNFGGFDLRAESLALMTKSGVNKGRFQDKGTTDYSNS
                     FGQSLNILGLARSGGVPSDAVKFLIKQQCAAGGFRLFPDTAAPTCDQATNPILDPDTTG
                     IAVQSLLTAYKSGNKAAGPAARKGALWLLGQQAADGSFKGSGPTASPNTNSTGLAGQAL
                     RAVGQSGLVSKTKARALNAGAAKAGRWVRTLQLTPGNAGKASGDVGAIAYNKAAFTEAQ
                     QNGITPAKRDQWRRANPQALLVLAGVALGDIGK"
     misc_feature    complement(3170..3186)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 24.68"
                     /tool="antismash"
     misc_feature    complement(3170..3186)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.66"
                     /tool="antismash"
     misc_feature    3170..3186
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.79"
                     /tool="antismash"
     regulatory      3177..3377
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            3745..4425
                     /locus_tag="K2F47_RS35615"
     CDS             3745..4425
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891588.1"
                     /locus_tag="K2F47_RS35615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_242910571.1"
                     /transl_table=11
                     /translation="MPAVTAAAALAEAAAFGSFFAVTVGGPGEGWRPAQDAYAQGMTDL
                     IAARAERYGTGEPRIAASVVQLGHAARLWSPMLACAVIHGIVIDLTGLQRADDGAVLRL
                     PDPVGLRVGEGARLAEALYRAVMDDHLRALAAGLRVKVASGLLDGNAASALVEAARALV
                     AARPALREAVRELTTALLNTGRLVGTGHITGPELGFRRRSCCLYYRVPGGEKCHDCALA
                     RRDR"
     misc_feature    4563..4583
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.45"
                     /tool="antismash"
     misc_feature    4632..4646
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            4760..4882
                     /locus_tag="K2F47_RS41120"
     CDS             4760..4882
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS41120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_272497912.1"
                     /transl_table=11
                     /translation="MAHHGFAEPDEPQKGLKSHTPAVDAPFEWREDEQDEQSES"
     gene            5001..7118
                     /locus_tag="K2F47_RS35620"
     CDS             5001..7118
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="K2F47_RS35620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_242910572.1"
                     /sec_met_domain="YcaO (E-value: 3.4e-64, bitscore: 212.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 3.3e-85, bitscore:
                     280.8, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRPIVQVEGDTPLGALVAGLLEPAAEVVRGTLDRALLSEIDLVI
                     CCAVRLPDARWQKIDRWCAEAGVPWHRCHAEGGRFYIGPFTASDSRDGDRSGDGAPTTT
                     YLDSRTRRLAAARSPEQLMAQWADAAGSAGEEAVNGDGNGPRPWPPGTPGSPDGEALVA
                     GLLVTDALAHLAGRPVPSRGHQIAVDLAPPTASLTYHPVLPLPLGHTSSAPPLVTGQAP
                     AAVHAGEEGHEDGMEQVARRLVDGRLGLISSLTRDRPRPGTVTACVSYTAQLSVHPRLT
                     PWVVDTTTGGAALVGHGPSPDEAYTEAPGGGHDRARWAALGEAAERYCANVVPDDLPTA
                     SYDDLVHARRPAVDPREFALYSPAQYAQRGFPFVPMTGDLKITWTPGRDLGDGAEVLVP
                     ASLTYVNYFRGPRRSEPPTNYPILAGTATGTSLHQAQRAALEEVLERDAVTLWWSSGAP
                     AAPLEVDTRAGPLGAALQEAEDGGLSVRFLRVPSTFQALVAAVFIEDRARRLVAFGSAC
                     RASAEEAAAKAFTEAIGMHETGLELADGKGAFWRAVHSGRIDHRPYRAYRKDRRYLKDF
                     RADWRDVNDLRLHPQVYLDPRMQDGRLDRLRTPGGLSPAPSGTVRGVDACLRMLTAQGL
                     RAVMVELTTPDVRSAGLRVVRVMVPGLYCNAPAAFPFLGGERLYREPAAHGWVPGPLTE
                     DRLVRDPLPFS"
     gene            7153..8175
                     /locus_tag="K2F47_RS35625"
     CDS             7153..8175
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03559.1"
                     /locus_tag="K2F47_RS35625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_308198522.1"
                     /transl_table=11
                     /translation="MRLGLALGYGGEPMEEVLPVVERAEAIGVDSVWSVEEYGPDAVSV
                     LGYLAARTERIKLGTAIMQIPARTPAATAMTAMTLDRLSNGRFQLGLGLSVPWIVEGWH
                     GQPYTRPLRRTREYVAIVRRAVAREERVRHDGEIYQVPYQGPGATGGARPVRSEMEPLR
                     PRIPLYLGAIGPRNVALVGEIADGWLSGMYAPEHEAALTRPLDEGIARAGRDPADVKIA
                     PILYVARADTAEEGRDQLRPLFAHLIGAAGAGVRNTYFDVACQMGYAGAAHDIRARHAD
                     GRKADAVAAVPDELLDQVALAGPLPLIVERILAWKDSRVDTLILLDRDTELLEAAQAAL
                     "
     gene            8172..9545
                     /locus_tag="K2F47_RS35630"
     CDS             8172..9545
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00797.1"
                     /locus_tag="K2F47_RS35630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MATE family efflux transporter"
                     /protein_id="WP_242910575.1"
                     /transl_table=11
                     /translation="MTASRHGPEPASAGMRPIWRLAYPLMVAGLTQIVLNIVDTVMLAR
                     LSTRALGAFALAAPIYLVALVIVRGWATAVQVQAAQHHGAGRTGDLARVVRTGVLTSAV
                     AGTAVGALLYVAATPLLTVLGGADELIGPGTDYLRVLAFAVPFAAVSFTLQGACAGTGA
                     ARVSMYTALLVNAVNLPLGLLLIFGADLGVTGAAAATLAATAAGTAYLLWYGRARLPRP
                     PDGPAQTVQITRGLWRIGWPEMIAMGVGYLNEALLAGFAARMGTDDLAAYRIVDNLVLL
                     LFTILTSASTAITILAGQALGAGHQDRAEAWRRAGLRLLGVLLLVPSAAVLLAGSPLIS
                     LITSDGAVADRAWSATPVALLSMVTLLAAMAYGAVLRAAGDTRSVMLASVTGDYAALIP
                     LAWLLGVYLGLGLPGLYLAWMAFGALYSLLLGRRYRRGARTPVRARPTATPAPEAEQR"
     gene            complement(9555..10748)
                     /locus_tag="K2F47_RS35635"
     CDS             complement(9555..10748)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017619117.1"
                     /locus_tag="K2F47_RS35635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_242910576.1"
                     /sec_met_domain="p450 (E-value: 1e-33, bitscore: 111.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRASTWGVSERQFWLHGRLPERLVEYDPDLDGWNVYGHPETVR
                     VASDSDSFSSDVDRILPEHMRMRSEGLLGKEDPPAHTRLRNFVRNAFTPKVVADLEPRI
                     AELTNELLDTVADQDRLELVADLAHPLPVTVIAELLGLPESDRGLVMHWGEEMLRVTAT
                     SLVDKSEEQARAMEATRVLVDDLTAYLGEHVAERRRRPREDLLTRLVEAEVDGERLTTE
                     QIRNLSRALLIAGHLTTTMLLGNTVLCLDAHPRHLARARADGSALPPIIEESLRLLSPS
                     VALRRVTTRDVEIGGVTVPANRLVKAWIAVANRDPRVFPDPEAFDPARDPNPHLAFSRG
                     AHFCLGAPLARLEGRVALGVLLARFPNLRIDPERPPEFIPNPGVIGLRKLPLLLTPS"
     gene            complement(10779..11558)
                     /locus_tag="K2F47_RS35640"
     CDS             complement(10779..11558)
                     /EC_number="1.14.11.-"
                     /GO_function="GO:0008198 - ferrous iron binding [Evidence
                     IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF047266.1"
                     /locus_tag="K2F47_RS35640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2OG-Fe(II) oxygenase"
                     /protein_id="WP_242910577.1"
                     /transl_table=11
                     /translation="MTFVEKIRDTSVDEAKADDISDVVHGSLGALRMEDFFSHADCRSF
                     VSALSPTMFEQYDPDYYQTEAFRIGPSLTEHRSSIEEYPPAAEKAWQTWHDGAFPVDLH
                     SIFRSKVQRIWNGRLRGASCRGKPAFWGMIRRMAAGTLVHWDDIREEFPGYVLDEALSD
                     QISVNVFLEGPAEGGELLVWSRARHSSDEAARISYGYDRARVVPEPPDVTLLPRTGDAV
                     MFSPLKYHLVEPVTKGDRLVFSVFMAIAEDGDLVVWA"
     misc_feature    complement(12006..12020)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.61"
                     /tool="antismash"
     misc_feature    12010..12025
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.95"
                     /tool="antismash"
ORIGIN
        1 ttcatcaggc tctcgtgcca cttcggcgag ccgatcatcg cgatgttgga gtcccgggcc
       61 gacaacgcga tggcgcgcgc ccgctcccgc tgcgcggcgt ccccggtcag cacctccggc
      121 agccgcgaca ggacggcctg ctcgtcgtcc tccagcaggc ccagcgcgtg gaacatgtgg
      181 aggaggatcg cgaagtactg cgtgacgtgg aacagcgggt actcgcggtc gggctcgctg
      241 agccgccagt aggcgatgga gacgtccgcc ttccgcccgg cctcggcgag ctgcccgccc
      301 gaggtcagca gcaggacgcg gtcacgggcg tgcgacagcg actcgaaggc gcgcagcggc
      361 tcctgcgaat ggccgctgta ggagctgatg atgatcaggg tcgcgtcgtc gtcgacgatg
      421 ctggagggaa gcaggaaagg gaattcgtag tcgttgacca cgaagacctc gatcggggag
      481 ccgatctcgg cgaagtagcc gcggatgatg tccgacacaa tggccgagca gcccatgccg
      541 gtgaacacga tgcgcttgaa cgttccactc ttaatccgtg cgcgtaggtc gggcttgacg
      601 tcgtcgatcg cgtactcctc gggcttgagg aagcccgcga agtattcttt ggagatgaac
      661 cggccgtaac gttccaggcg actttccatg gcgcacactc cagcgtggtt gggacatcac
      721 gagattcgtg cccagctgca cacgggaaat ccatcggccc actccgtggt cttacaggga
      781 ccgatcctcc ccgtcggggc aagagtaagc agggcccctt tggacaatca aggccgctgc
      841 ggcaccttga tcacccggcg gcgcggccgc accggagagc cgacccagaa tttgcagctc
      901 agaagagatc ttggggcgcc tgacgcagcc gcctgtgatc cacgtaacag cagcctcgcc
      961 ggcaactccc ctgaatccag acagaaggca atcggagtgc aatcgcgcct cagtcgacac
     1021 accgaaccat gaaccgctcc aacttttggg aacgggcggg caagattttt tgcgaagacc
     1081 tcaatccggc cgccttgaat tcgatcgttc caacgacaac cggccccgcg cccccgccct
     1141 aggaccctct caactggact gacctgcggc actcccgccg ccccggccgc aacgacgtct
     1201 aaagggactc gcgctttccc tggaaacggc cgtgccgcat caagttggtt gatgcagcaa
     1261 ctaatgcagg gtgggtgctc cccgcgcgtc cggcgctccc ggctacgccg agccacgccc
     1321 atggaccgcg gccgcccggg cccccggcag ccctggcccg gcccgggcgc agccccggcc
     1381 ctgccgagcc ttcgaggccg tgccggggag cgccggcgtt gatctcgtaa tgatcgtctc
     1441 tgttccgctc cataccgaca tccccgagaa cagcggctcc ttcggccccg ctcacctcat
     1501 cgtcaacaaa gagccagtac ttgttcctgg acctggaacc gcccacttcc cgatgtgatc
     1561 atcggctggt gatcaagccc cggccccggt ctcggccagt gccgttgcca aggccgccgc
     1621 gccagtgagg ggcctcggcg cgcgcgtcgt cgcacggagc ggtattcacg cgctccaggc
     1681 cggtggggaa aatcggaagc cggctcgtcc agatccggac atggcggctg actccgcggc
     1741 ggtaataggc tttgctggac aaattcgcgc gcgccaccca tttccgccgc cgtggtccgc
     1801 agaacggagt cccggccgcc gggccgccgt gccgggcggt gctgaggcgg ctgtccacga
     1861 ttcgaagcga agggcgtgat ttcatgcaca tcgccgtccg ccacatgttt gttcctctca
     1921 ccgtgggagc cgtcgccttc accggcctga ctgtgcccgc acaagccgcg tcgcatccct
     1981 cggcggtgag ggccgcccga tggcaggcga cccaactcga cgccaagggc ggtatcttca
     2041 acgaccagtt caacttcacc gactggggac tgaccgccga cacggtcatc gccctcaaag
     2101 cgaccggcgt gaaaccgcag atcgccaaga agtcgaccgc ctacatcgcc gcgcacgtgc
     2161 gctcgtacaa cagtctcgac gactcgggcc agcccggcgt ccgcttttcc ggtccgaccg
     2221 gcaaactgct ctacctcgcc accgcgacca agtcgaaccc gcggaacttc gggggtttcg
     2281 acctgcgcgc cgaatcgctg gccctcatga cgaagtccgg cgtcaacaag ggccggttcc
     2341 aggacaaggg caccaccgac tacagcaata gcttcgggca gtcgctcaac atcctggggc
     2401 tcgcgcggtc cggaggcgtc cccagcgacg cggtgaaatt cctcatcaaa cagcagtgcg
     2461 ccgccggtgg cttccgcctc ttccccgaca cggcggcgcc cacctgcgac caggccacca
     2521 acccgatcct ggatcccgac acgaccggga tagcggtgca gtccctcctc accgcataca
     2581 aatcggggaa caaggcggcg ggtcccgccg cccgcaaggg cgcgctgtgg ctgctggggc
     2641 agcaggccgc ggacggctcc ttcaagggat cagggccgac cgccagtccc aacaccaaca
     2701 gcaccggcct ggccgggcag gcgcttcgcg ccgtcggcca gtcgggtctg gtgagcaaga
     2761 cgaaggcgcg cgcgctcaac gcgggtgccg ccaaggcggg ccgctgggtc aggacgctgc
     2821 aactgacccc cggcaacgcc ggcaaggcgt ccggtgacgt cggggccatc gcctacaaca
     2881 aggcggcctt caccgaggca cagcagaacg gcatcacccc cgcgaaacgc gaccagtggc
     2941 gccgggccaa cccgcaggcg ctcctggtcc tcgccggcgt cgcgctcgga gacatcggca
     3001 agtagctctg acgaccgagc tcgtcctctt ggcggtgacc gcctgcgacg ggccggtggt
     3061 cgggtgtgcg gtcggaacag ggaagcggcc ctgctcggtg gcgcgatcgg cgccaccgag
     3121 cagggcgcga acgtagcggg cggctgctcg accggccgtc cccccgttat tgcgacttta
     3181 ttgcaagtgc gacctgtgcc accatgagtg gtgtaggcga cggcggaacg aggaagccgg
     3241 tgtgaatccg gcgcggtccc gccactgtga tcggcgagcg gatcccgatg gcgccactgc
     3301 ccgtgcgagc gggtgggaag gcggggacga gcgttgaccc gagagccagg agactcacgc
     3361 ggtcgcctcc tcaaggaact ggggcggatt tccccagaga ggagggcggt atgcccgtgg
     3421 gttcgccgga cccggtgccg tgccgggtga cgaccggcgt taccgagcca cctacttccc
     3481 gcggcgatga cgtgtcggcc gccgcctccg cccatccgcg cggccgcgcc ggtgctgcgc
     3541 agagtgccac cgcgtccgag atcacatccc cgacatatga gtcaagaggg gaaggtgatc
     3601 gcccggaacc ttgatgtcaa gaatagggtc gtcacgcctg ggatcggaac ggttctcagg
     3661 tgcaggtccc atgccctgaa taactgatgt cgacgtcttt tcggtaacgc atctcagtag
     3721 attggatccc ttgaggtgac tttcgtgccc gctgtgaccg ccgccgcggc actggccgag
     3781 gccgccgcct tcggctcgtt cttcgccgtc accgtgggcg gcccgggtga gggctggcgg
     3841 ccggcccagg acgcctacgc ccaggggatg accgacctga tcgccgcgcg cgccgaacgg
     3901 tacggcaccg gcgaaccgcg gatcgccgcc tccgtcgtgc agctggggca tgcggcacgc
     3961 ctgtggtcgc cgatgctggc ctgcgcggtc atccacggca tcgtcatcga cctgaccggg
     4021 ctgcaacgcg ccgacgacgg cgccgtcctg cggctgcccg accccgtcgg cctgcgcgtc
     4081 ggtgaggggg cgcggctggc cgaggcgctg tatcgagcgg tgatggacga ccatctgcgg
     4141 gcgctggccg ccgggctgcg cgtcaaggtc gcctccgggc tgctggacgg caacgccgcc
     4201 tccgcgctgg tggaggccgc gcgggccctg gtggcggcca ggcccgcgct gcgggaggcg
     4261 gtacgggagc tcaccaccgc cctgctgaac accgggcggc tggtgggcac cggacacatc
     4321 accggtccgg aactggggtt tcggcgccgc agctgctgcc tgtactaccg cgttcccggc
     4381 ggggagaaat gccacgactg cgccctggct cggcgggacc ggtgatggtc gtggacggag
     4441 cggggtgggc cggagcgccg actgcggttc cggtcgtcgg cagcactatt tacggttgtc
     4501 tttatggtgc tgcaatatgt cacgcgtgcg attcgtgacg actagtgtcc gcaggtgacc
     4561 gctttgcggc gaagtgacga tattgccagc gagtaaattc atcttaaagt cgcaggttga
     4621 tcggtggagg gcgacgcaat cggccaaatg cgcattgact ctgcttgact gatatgccta
     4681 atgtcggcga caggtagaga agctcgcaaa gcgggcgagg tcttgcctgc cgcgtgggcc
     4741 accacgaagg aggatgcaca tggcgcacca cggtttcgcc gagccggacg agccccagaa
     4801 gggcctgaag tcccacaccc cggctgtgga cgctccgttc gagtggcgtg aggacgagca
     4861 ggacgagcag agcgagagct gatccataga cggggaggcg gcgccgcagc cgcctccccg
     4921 tcgcacgccg cgaccggtga atgctcatag gaaagtccgc atatcgacga cggatgcccc
     4981 gggaaatgag gaaacggccg ttgaaacgcc cgatcgtgca ggtcgaaggc gacactccgc
     5041 tgggagccct ggtggcgggg cttctggagc ccgcggccga ggtggtgcgg ggcacgctgg
     5101 accgtgccct gctcagcgag atcgacctgg tcatctgctg cgcggtacgg ctgcccgacg
     5161 cacgttggca gaaaatagac cgctggtgcg ccgaggccgg ggtgccctgg catcgctgcc
     5221 atgctgaggg cggccggttc tacatcggcc ccttcaccgc gtccgactcg cgcgacggcg
     5281 accggtccgg cgacggggcg ccgaccacga cctacctgga ctcgcggacg cggcggctgg
     5341 cggccgcccg gtctcccgaa cagctcatgg cccagtgggc cgacgcggcc ggcagcgccg
     5401 gcgaagaggc cgtgaacggc gatggaaacg gcccccgtcc gtggccgcct gggacacccg
     5461 gatcaccgga cggcgaggcg ctcgtcgccg ggttgctggt gaccgacgcg ctcgcccatc
     5521 tggccggacg gcccgtgccg agccgcgggc accagatcgc tgtcgacctg gcaccgccga
     5581 ccgcctccct cacctaccac ccggtcctgc cgctgcccct cgggcacacc tcctccgcgc
     5641 cgccgctcgt gaccgggcag gcgccggccg ccgtccacgc cggcgaggag ggtcatgagg
     5701 acggcatgga gcaggtcgcg cgacggctgg tggacggcag gctggggctg atcagcagcc
     5761 tcacccgcga ccggccgcgc ccgggcaccg tcaccgcctg cgtctcctac accgcccagc
     5821 tgtcggtgca cccgcggctg acgccctggg tggtcgacac caccaccggc ggcgcggccc
     5881 tcgtcggtca cggcccgtcc cccgatgagg cctacactga agctcccggt gggggccatg
     5941 atcgggcgcg gtgggcggcg ctcggcgagg ccgccgaacg gtactgcgcc aacgtcgtgc
     6001 cggacgacct gccgactgcg tcctacgacg atctggtgca cgcgcgtcgg ccggccgtcg
     6061 acccgcgcga gttcgccctg tactcaccgg cgcagtacgc ccagcgcggc ttcccgttcg
     6121 tgccgatgac cggcgatctg aagatcacct ggacgcccgg ccgtgatctc ggcgacggcg
     6181 cggaggtcct ggtgcccgcg tcgctgacct atgtcaacta cttccggggc ccacgccgga
     6241 gcgagccgcc caccaactat ccgatcctgg cgggcacggc gacgggcacg agcctgcacc
     6301 aggcgcagcg tgcggcgctg gaggaggtgc tcgaacgcga cgcggtcacg ctgtggtggt
     6361 ccagcggcgc ccccgccgca ccgctggagg tggacacgcg cgcgggtccg ctgggcgccg
     6421 cgctccagga agccgaggac ggcggactgt cggtgcggtt cctgcgcgtc ccctcgacgt
     6481 tccaggcgct ggtcgccgcg gtgttcatcg aggaccgcgc gcggcggctg gtcgccttcg
     6541 gctcggcctg ccgcgcctcg gccgaggagg cggcggccaa ggcgttcacc gaggccatcg
     6601 gcatgcatga gaccggcctg gagctggccg acgggaaggg cgccttctgg cgtgcggtcc
     6661 actccgggcg tatcgaccac cgcccgtacc gggcgtaccg gaaggaccgc cgctacctga
     6721 aggacttccg cgccgactgg cgggacgtca acgacctccg gctgcatccg caggtctatc
     6781 tcgacccgcg gatgcaggac ggccggctgg accggctgcg aactccgggc ggattgagcc
     6841 ccgcgccgtc cggcaccgtc cggggagtgg acgcctgtct gcggatgctg accgcccagg
     6901 ggctgcgcgc cgtgatggtc gagctgacca cgcccgacgt gcgctcggcg gggctgcggg
     6961 tggtgcgggt catggtgccg gggctgtact gcaacgcccc ggccgcgttc cccttcctgg
     7021 gcggtgagcg gctgtaccgg gagccggccg cccacggctg ggtaccgggc ccgctcaccg
     7081 aagaccgtct tgtccgtgat cctttgccgt tctcctgacg cggcatggac tgcttgaggg
     7141 aaggatgaac gcgtgcgtct tgggctggca ctgggatacg gcggagaacc catggaggag
     7201 gtgttgccgg tcgtcgagcg tgccgaggcg atcggtgtgg actcggtgtg gagcgtggag
     7261 gagtacggcc cggacgccgt cagcgtcctc ggctacctgg ccgcccgcac cgagcgcatc
     7321 aagctcggca ccgcgatcat gcagatcccc gcgcggaccc cggccgccac ggcgatgacc
     7381 gcgatgaccc tggaccggct gtccaacggg cgcttccagc tgggcctggg actgtcggtg
     7441 ccgtggatcg tcgagggctg gcacggccag ccctacacgc ggccgctgcg gcgcacccgc
     7501 gagtacgtcg cgatcgtccg cagggcggtc gcccgggagg agcgggtccg gcacgacggt
     7561 gagatctacc aggtccccta ccaggggccc ggagccaccg gaggagcccg tccggtccgc
     7621 tcggagatgg agccgctgcg cccgcgtatc ccgctgtacc tgggcgcgat cggcccccgc
     7681 aacgtggcgc tggtgggcga gatcgccgac ggctggctgt cgggcatgta cgcccccgag
     7741 cacgaggcgg cgctgacccg tcccctggac gagggcatcg cacgggccgg gcgcgacccc
     7801 gccgacgtca agatcgctcc gatcctgtac gtggcgcgcg ccgacaccgc cgaggagggc
     7861 cgcgaccagt tgcggccgct gttcgcgcac ctgatcggcg cggcgggcgc gggcgtgcgc
     7921 aacacctact tcgacgtggc ctgccagatg gggtacgcgg gcgcggccca tgacatccgc
     7981 gcccgccatg ccgacgggcg caaggccgac gccgtcgccg cggtcccgga cgagctgctc
     8041 gaccaggtcg ccctggccgg gccgctcccg ctcatcgtcg aacggatcct ggcctggaag
     8101 gattcgcggg tggacacgct gatactgctc gatcgcgaca ccgaactgct ggaagccgcc
     8161 caggccgccc tgtgacggca tcgcgtcacg ggccggagcc cgcgtcggcc gggatgcggc
     8221 cgatctggcg gctggcctac ccgctgatgg tcgcggggct cacccagatc gtgctcaaca
     8281 tcgtggacac ggtcatgctg gcgcggctgt cgacgcgggc gctgggggcg ttcgcgctgg
     8341 ccgcgccgat ctacctggtg gcgctggtca tcgtgcgcgg ctgggccacc gccgtccagg
     8401 tgcaggcggc ccagcaccac ggcgcgggac gcaccggcga cctcgcgcgg gtcgtgcgga
     8461 ccggcgtcct cacgtccgcg gtcgccggga ccgccgtggg cgccctgctg tacgtggccg
     8521 ccacgccgct gctgaccgtc ctgggcggcg cggacgagct gatcggtccg ggcacggact
     8581 acctgcgcgt cctggccttc gccgtgccgt tcgccgccgt ctccttcacc ttgcagggcg
     8641 cgtgcgcggg caccggcgcg gcgcgggtct cgatgtacac ggccctgctg gtcaacgccg
     8701 tcaacctgcc gctcggcctg ctgctgatct tcggcgcgga tctcggcgtc accggcgcgg
     8761 cggccgccac cctggccgcc accgccgccg gaaccgccta cctgctctgg tacggccgcg
     8821 ccaggcttcc ccggccgccg gacggccccg cccagaccgt ccagatcacc cggggcctgt
     8881 ggcggatcgg ctggccggag atgatcgcga tgggggtcgg ctacctcaac gaggcgctgc
     8941 tggccgggtt cgccgcccgc atgggcaccg acgacctggc ggcctaccgc atcgtcgaca
     9001 acctcgtcct gctgctgttc acgatcctga ccagcgcctc caccgccatc acgatcctgg
     9061 ccggccaggc gctcggcgcc ggccaccagg accgcgccga ggcgtggcgc cgcgcggggc
     9121 tgcgcctgct gggcgtcctg ctcctggtcc cctccgccgc cgtgctcctc gccggaagcc
     9181 cgctgatctc cctgatcacc tccgacggcg cagtcgccga ccgcgcctgg tcggcgacgc
     9241 ccgtggcgct gctgagcatg gtgacgctgc tggcggccat ggcctacggc gccgtgctgc
     9301 gcgcggcggg agacacccgc tccgtcatgc tcgcctccgt gaccggcgac tacgccgcgc
     9361 tcatcccgct cgcctggctg ctgggcgtgt acctcggcct cggcctgccc ggcctgtacc
     9421 tcgcctggat ggcgttcgga gcgctgtact cgttgctgct aggccgccgc tacagacggg
     9481 gtgcgcggac gcccgtccgc gcacggccga cggccacccc ggcaccggaa gccgaacagc
     9541 gatgagcacc gggctcagga gggagtcagg agcagcggga gtttgcggag gccgatgacg
     9601 cccgggttcg gaatgaactc gggtggacgt tccgggtcga ttctcaggtt cgggaagcgg
     9661 gccagcagaa cgcccagcgc gacccgtccc tccaggcggg ccagcggggc gccgagacag
     9721 aaatgggcgc cgcggctgaa ggcgaggtgg gggttggggt cccgggcggg gtcgaaggcc
     9781 tccgggtcgg ggaacacccg cggatcccgg ttggccaccg cgatccacgc cttgaccagg
     9841 cggttcgcgg gcaccgtcac gccaccgatc tcgacgtcac gggtggtgac gcgcctgagc
     9901 gccaccgacg ggctgaggag gcgcagcgac tcctcgatga tcggcggcag ggcggagccg
     9961 tccgctcggg cgcgggcgag gtgccgcgga tgcgcgtcca ggcagagcac ggtgttgccg
    10021 agcagcatcg tcgtggtgag gtgcccggcg atcagcagcg cccgcgagag gttccggatc
    10081 tgctcggtgg tcagccgctc gccgtccacc tcggcctcga cgagcctggt gagcaggtcc
    10141 tcgcgcggtc ggcgccgccg ctcggcgacg tgttcgccga ggtaggcggt gaggtcgtcg
    10201 accaggacgc gggtggcctc catggcgcgg gcctgctcct cgctcttgtc gacgagcgac
    10261 gtcgccgtca cccgcagcat ctcctcgccc cagtgcatga cgaggccgcg gtcgctctcg
    10321 ggcaacccga ggagttcggc gatcaccgtg accggaagcg gatgggcgag gtcggccacc
    10381 agctccaggc gatcctggtc ggccaccgtg tcgaggagtt cgttcgtcag ctccgcgatg
    10441 cggggttcga ggtcggcgac caccttcggg gtgaacgcat tcctgacgaa gttgcgcagc
    10501 ctcgtgtgcg ccggagggtc ctcctttccg aggaggcctt cggagcgcat cctcatgtgc
    10561 tcgggcagga tgcggtcgac gtcagaggag aaggagtcgg agtcgctcgc gacccgcacc
    10621 gtctccgggt ggccgtagac gttccagccg tcgaggtccg ggtcgtactc gacgagccgc
    10681 tccggcagcc gaccgtgcag ccagaactgc cgctcggaaa cgccccaggt actggcgcgg
    10741 agagtcatgg gtgccctttc agtggacctg ctcgttcgct acgcccacac gaccagatcg
    10801 ccgtcctcgg cgatcgccat gaacacggag aacaccagcc ggtcgccctt ggtcaccggc
    10861 tccaccaggt ggtatttgag cggggagaac atcaccgcgt caccggtccg cggcagcagc
    10921 gtcacatccg gcggttcggg gacgacccgg gcgcggtcgt agccgtaact gatccgggcg
    10981 gcctcgtccg acgaatgccg ggcacgtgac cacaccagca gttccccgcc ttccgccggg
    11041 ccctccagaa agacgttgac gctgatctgg tcggagagcg cctcgtcgag gacatagccg
    11101 gggaactcct cccggatgtc gtcccagtgc accagcgtgc cggccgccat ccggcggatc
    11161 attccccaga aggcgggctt tccgcggcaa ctcgccccac gcagccgtcc gttccatatt
    11221 cgctggacct tgctgcggaa gatggagtgc agatctaccg ggaacgcgcc gtcgtgccag
    11281 gtctgccacg ccttttcggc ggcgggcggg tactcctcga tgctcgaccg gtgctcggtc
    11341 agcgacggcc cgatccggaa ggcctcggtc tggtaatagt ccggatcgta ctgctcgaac
    11401 atcgtcggac tcagcgccga gacgaagctt cgacaatcag cgtgggagaa gaagtcctcc
    11461 atgcggaggg cacccagtga accgtgcacg acatccgaga tgtcgtcggc cttcgcctcg
    11521 tcgacgctgg tgtctcggat cttttcgacg aaagtcacga gtagctcctt tctgcggcac
    11581 catacgtcga cccggctgcc cgaacgttca gtggattccg aaccggcgac gccggagggc
    11641 acaggccccg tcactgggcc ggaacggcca gacggcactc cgcgcctctc acgcgggcgc
    11701 tcggcggatc ggtgtccaag ggggccaata gaaggatcac gccggtcggt cctcactcgg
    11761 ggtccgcgcc ccggacacgg gggtgggagc gcaccggact ctcaacggct tcctccgttt
    11821 gccgccgcac atctccacac ccactgtcat ggtcatctac agccgcgtca agggccccga
    11881 tcacgtcctt ccggatcggt ggtgcaccgg ctgtactcgc gtaacccttc ttgcctggtc
    11941 cgcgtccgtc cgccgcccgt gaagccgaga cctgcgcgga tccgccgccc ctcgaacgcc
    12001 gaccggccaa atgatattca tgattcagcc ggtgcattcc tgcggtatcg acggcggagc
    12061 gaggagacgc ggatggccgc cctgtccctg cgaggcgctg acattgacgc ctacctgg
//
