LOCUS       NZ_JAICDG010000007     22651 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinomadura terrae strain OS3-83 contig7, whole genome shotgun
            sequence.
ACCESSION   NZ_JAICDG010000007
VERSION     NZ_JAICDG010000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura terrae
  ORGANISM  Actinomadura terrae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 453487)
  AUTHORS   Lee,S.D., Yang,H.L., Kim,I.S., Choe,H. and Kim,J.S.
  TITLE     Actinomadura terrae sp. nov. and Actinomadura litoris OS3-89,
            isolated from rhizosphere soil of cactus
  JOURNAL   Int J Syst Evol Microbiol 73 (1) (2023)
   PUBMED   36748505
REFERENCE   2  (bases 1 to 453487)
  AUTHORS   Lee,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2022) Institute of Jeju Microbial Resources, BioPS
            Co., Ltd., Sancheondan Dongil 16, Jeju 63243, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 141x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022751215.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:12:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,085
            CDSs (total)                      :: 8,002
            Genes (coding)                    :: 7,936
            CDSs (with protein)               :: 7,936
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 2, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 13 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 3 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 299035
            Orig. end                         :: 321686
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAICDG010000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22651
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="2"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22651
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22651
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12651](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12651)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    233..247
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.79"
                     /tool="antismash"
     gene            complement(635..1693)
                     /locus_tag="K2F47_RS35450"
     CDS             complement(635..1693)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852796.1"
                     /locus_tag="K2F47_RS35450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron-containing redox enzyme family protein"
                     /protein_id="WP_242910535.1"
                     /transl_table=11
                     /translation="MTVGHVPGRFAEGAPERGRAPAPPPSRGLLSRTVADTLTAGPPGS
                     FVRSPDLFAAVVAADPFGDDLQLALYMCYELHYRGFAGVDADWEWDAGLLRLRGEMEAV
                     FLDALRRETVPGTDVEEALEGLLTEPVDGEGVSHHLRDNGAGWQLLEHAALRSVYHLKE
                     ADPHAFVVPRLRGQAKTALVAVEHDEFGGGRPEMIHQGLYADLLDDLGLDPSYGAYVDA
                     APAAMLATVNMMSLFGLRRSLRGALVGHFAAAEITTAPSARRMAAALERLGGGPRARLF
                     YTEHIEADAVHEQVLRHDVIGGLLADEPELAADVVLGVRATVLLEDRLGAHLLESWRSG
                     RSALRRQVTENR"
     gene            1853..3385
                     /locus_tag="K2F47_RS35455"
     CDS             1853..3385
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020906.5"
                     /locus_tag="K2F47_RS35455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1990 family protein"
                     /protein_id="WP_242910536.1"
                     /transl_table=11
                     /translation="MTGLGWSARVWRSARADGDAITRRTSGDVVRVRWRRRVRALRWPV
                     GMGIASWRWLRRSRQVRRRRIRTGILSEAERIPQRSGAQTQHVRQGVGLTYQRRYVVQI
                     SGSPISAAQLIQRLGGDLNAASPVEIAVFDKTSGGSRRLEVGDEYVVHMPGPWNCPVRV
                     VERTPVSFRFATLRGHMEAGEIEFRVGDAREGDLVFTIESWARSGDRLADLLYEKVGIA
                     KEMQSHMWAHFCRRVAEIAEGEVVGDVEIQTERSDMFRARSGNQSITRAVDAAFARSFA
                     LAARLRNRPLHPRGLVFDALLRLHGTSQHRGVPFLDDHTELRGRARLSRAVGLPPPLPD
                     VLGLALRWPQPQADLTGDHSTAELLLAATGQTVPGRHLLRPMTRWSPAFYGSLLTYRVG
                     DRRVLLGAVARRTRIAPADLTTLARAVDERPLLLDLVVATEFGPWEPFGELRLIGPARS
                     DDLEPMRFNPARHPIRELHPEGLLQRARGSSYSAVQRVARHGADHRPERPSS"
     gene            3382..4563
                     /locus_tag="K2F47_RS35460"
     CDS             3382..4563
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020906.5"
                     /locus_tag="K2F47_RS35460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1990 family protein"
                     /protein_id="WP_242910537.1"
                     /transl_table=11
                     /translation="MTRKERARQRMRRRHADLHRCRLNFDPRQHDMTRPEPGWNLDDYR
                     QQLPPEPPGPPVPGGSWEIARRLVRGYQYADPRIIREICRSGPPEPGRDMLLEARFYGL
                     RFHLGLRVGDVVDTTIERDGRPVRVWGWNYQTLEGHLERGQMDQEVRKWLDTGEVEFHI
                     HVFSQAAPTPHPIVRLGFLFFGRYMQLKFYKRACRRMKALTAAALGAPRVCPAASGYRP
                     RMEETRSRQLLGIYLNDHLAAAAGGVGLAYRLARGHRGSDDAEQLRRLADDIAADRGAL
                     LAILKSLGLPARRYKSVAVWTAEKAGRLKLNGSLLRRSPLSDVVELEALTLAVHGKRAG
                     WRTLLAVAEQEPALDTEHLRKLQARADDQLTVLERLRTATSEKVFRQGQPAAQ"
     gene            complement(4589..5245)
                     /locus_tag="K2F47_RS35465"
     CDS             complement(4589..5245)
                     /GO_function="GO:0004089 - carbonate dehydratase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009080631.1"
                     /locus_tag="K2F47_RS35465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbonic anhydrase"
                     /protein_id="WP_242910538.1"
                     /transl_table=11
                     /translation="MTDIEAMSPKAAFELLLAGNRRFVAGTPEHPNQDAARRTEVAASQ
                     RPFAVLFGCSDSRLAAEIIFDRGLGDLFVVRTAGHVMGPEVLGSIEFGVGELGAPLVVV
                     LGHEGCGAVGAACAALENGVPPSGYVRDVVERVTPSVLAARAAGSVRAEDILAEHIRYT
                     VDLLLDRSRLLSERVAAGQAAVAGLCYGLADGTARLFAAHGQDLPVADPRSRVHN"
     gene            complement(5300..5932)
                     /locus_tag="K2F47_RS35470"
     CDS             complement(5300..5932)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017601975.1"
                     /locus_tag="K2F47_RS35470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="fasciclin domain-containing protein"
                     /protein_id="WP_242910539.1"
                     /transl_table=11
                     /translation="MKRTRITAGVLSAAVLTVGLAACSGDDDNASSTASPSAAAPSATG
                     AAAPAMDKPFGPACTAVPASGKGSFGGMAADPVATAASNNPVLSTLVGAVKQAGLVDTL
                     NSAQHITVFAPTNDAFAKIPKGTLGKVMADKETLKGILTYHVVGQKIAPGGLPSGSFTT
                     LQGATLSTSGSGDSFTVGTGKANVVCGNIQTANATVYIIDSVLMPPK"
     gene            complement(5996..7507)
                     /locus_tag="K2F47_RS35475"
     CDS             complement(5996..7507)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618218.1"
                     /locus_tag="K2F47_RS35475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_242910541.1"
                     /transl_table=11
                     /translation="MRWVTAALHGLLAAAAALGSAELAAGAIGRATASPILAVGAGFID
                     LTPVRLKDFAIRTFGDDDKAVLLAGLGCGTAMAAVAVGLLSRGRPLRGAAGLAAFGIVG
                     VVAALTRPAADLVDAVPAVVGAACGMAALTLLAARSREGAGPARVDDRRRALLTGAGVA
                     AAAAVSGAGGRALLRRGNVSAVRARLRLPPPVSPAAPVPPGAQVRVPGMTSFRTSNAAF
                     YRVDTALVLPQVDPRDWTLRIHGMVARPIELTFDDLLRQALVERDITLACVSNQVGGDL
                     AGSARWLGAPLAAVLRRAGVRAGADQILSRSSDGMTLGTPLEAVLDGRDALLAVGMNGE
                     PLPVAHGFPARMVVPGLYGYVSATKWVVDLKVTRFATDQAYWTKRGYAEHAPVKTFSRI
                     DVPKPFARLKAGPVAVAGTAWAQHRGIDAVEWQVDDGPWRPARLAPVPGIDTWRQWLAE
                     WDASPGSHTLRVRAVDGTGTTQPEHRTPPFPDGATGWHSVVVTVT"
     gene            7636..8214
                     /gene="sigK"
                     /locus_tag="K2F47_RS35480"
     CDS             7636..8214
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene="sigK"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017557580.1"
                     /locus_tag="K2F47_RS35480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ECF RNA polymerase sigma factor SigK"
                     /protein_id="WP_242910542.1"
                     /transl_table=11
                     /translation="MTDPSSGRAAPSGVPDLGELLSQVARGDRDAFEQVYERLCGPVYG
                     TALRVVRDPAQAEEVAQEVLVEVWRKASHYRPDRGSATAWALTMAHRRAIDRVRSAQAG
                     RVREERAGVPDPDYDVVAEQVGTRLEHQQVRRCLRGLTPTQRESITLAYYGGYTYREVS
                     ELLGVGLAAVKTRMRDGLIRLRDCLGVQS"
     gene            8211..8930
                     /locus_tag="K2F47_RS35485"
     CDS             8211..8930
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021604.5"
                     /locus_tag="K2F47_RS35485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="anti-sigma factor domain-containing protein"
                     /protein_id="WP_242910543.1"
                     /transl_table=11
                     /translation="MTHDPHHLAAAHALDALPDAERRRFERHLSGCSSCAQEVAGLREA
                     TARLALAASRQPPPALRDRVLAEIGRTRQSPPRLARRLPPAPRRGLSWLAAAACLVLAL
                     ACGITAVHLHGTAERAREADRRIAAVMTAPDARTSTARTRDGATVTVVSSRSLDQAVIT
                     TSRLRRLPPARTYQLWFLAASAAPRSGGVLRPPADGPSQPIIASGLGTAQQVGMTVEPA
                     GGSARPSTAPFLTLPLT"
     gene            complement(8911..9936)
                     /locus_tag="K2F47_RS35490"
     CDS             complement(8911..9936)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017533076.1"
                     /locus_tag="K2F47_RS35490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_242910544.1"
                     /transl_table=11
                     /translation="MTRLLVLGGTAFVGRAVVDAALRRGWKVTTFSRGVTGPPPSGAEA
                     LTGDRTDPDGLRALAGREWDLVIDTWRDDAAAVTAAARALEPSVGRYAYVSSLAVYAWP
                     PPAEFTEDAPLLDPDSGSSGGIFGSYALAKAGGEHAVRAAFGDRALLARTGLILGPHEY
                     AGRLPWWLLRVARGGRVAAPRPSDLPLQYIDTRDLAEWLLDAEENGLAGDFNVLSDVGH
                     ATMASLLAACRAVTGGGADLTWVDGDVLLAHGVRPWMELPIWIPPGNVLEPSYRVDSTK
                     AKAAGLHCRPVHDTVADTWRWLRSEPDHGRRAGQDKPWMTPEKEAEVLVAWDRLLRSAG
                     G"
     gene            complement(10001..11779)
                     /locus_tag="K2F47_RS35495"
     CDS             complement(10001..11779)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="K2F47_RS35495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_242910545.1"
                     /sec_met_domain="Asn_synthase (E-value: 7.2e-20, bitscore:
                     66.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSALVGFHGLRGDAAPAQRLRELAGEDGPRAAGDGWMIAAVGGGT
                     LPGDDAPVEIRAGDVTRGLLSGRLFDSADGRRDHRCRDPLPLDWAAPRGELARRRWGRY
                     AAAAVRPDGALVLIRDPIGLLPLFYAPHGTGHVFATRMELLVELLGRRPGFDWEHLGSF
                     MTRGPGPTDRTAFQGVAQLSPGEVVQIADGRTTSEPLWDPVAACADGDAPSPDEVRHAL
                     LDCTRAWLAEAESVALDLSGGLDSSSVCWAARNSVADEAALHGRFVRFPLGASVDERPA
                     AERVARFLRTPLTIVDAADRLPLAPTKGRLPRADAPQLQYAEARLNEVLAEEAGPGAEA
                     LSGGAGDQLFLMRSTPGYHADHLLGGGLGAGHVLGGLRELWRESTLAERSLPALLAEVG
                     TETARRIRGGTAIPDGMLDAPRPAWLAPDSPPSPLRLPDGIDGLSAARAFQLTGILYWG
                     DAVDREHRNPHRPSVYPMLSQPLVELALRAPMRSLVGHRGDRLLLRDAMAGTLPRAVVD
                     GRSKGSYAGMYQHSLRLHRDLCRELILDGRCVANGLVDPGPALEDLQRTALGFTRGPNW
                     PLYSLLSVEMWCQTWN"
     gene            complement(11776..12651)
                     /locus_tag="K2F47_RS35500"
     CDS             complement(11776..12651)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS35500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="lasso peptide biosynthesis protein"
                     /protein_id="WP_242910546.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 8.9e-14,
                     bitscore: 46.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF13471 (E-value: 6.8e-08, bitscore: 27.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGKGKGATVLEAVDSAPFPHHVECPAGLNPVPRSAPPDPADGTA
                     LRSAPDVHWAWWDDELVALDLASDRFVALDSAASGAVSEALTSEAPPSSPSARRILDGL
                     CARGLLVTAASTDPGWEPVRPTRPGGVSSFAPQPLKGLSTHSAPPPTPATLALAARLLA
                     DSEGRLRRHGLLTPPRDARRPRLPEQAGDPGSDELVRARTLVRAHLVVRGLLARPSNPL
                     SAAAALARHAWRMGLPAHLVLGVQKYPFHTRVFVELHRVVLDDAQEVVDALAPILVIGP
                     ETAGAGEVSP"
     aSDomain        complement(12307..12519)
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K2F47_RS35500_Lasso_Fused_RRE.1"
                     /evalue="5.80E-15"
                     /identifier="RREFam003.1"
                     /label="K2F47_RS35500"
                     /locus_tag="K2F47_RS35500"
                     /protein_end="115"
                     /protein_start="44"
                     /score="46.1"
                     /tool="antismash"
                     /translation="ALRSAPDVHWAWWDDELVALDLASDRFVALDSAASGAVSEALTSE
                     APPSSPSARRILDGLCARGLLVTAAS"
     gene            complement(12671..12838)
                     /locus_tag="K2F47_RS35505"
     CDS             complement(12671..12838)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS35505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242910547.1"
                     /transl_table=11
                     /translation="MIRGLARVVVLLPGGSRKGPGTETPKPDGGAGARPEKEQPGKDAA
                     VPEENTYPLW"
     gene            complement(12835..13842)
                     /locus_tag="K2F47_RS35510"
     CDS             complement(12835..13842)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS35510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242910548.1"
                     /transl_table=11
                     /translation="MSFRDLEAGHRKRRYTLVPQFEDYDGNELHLRPYMTLGSRPGITG
                     EVFSTDAEGFRVSTSPQGPVDTRSWPESGGGIALGGSYVFGVGATSDEATLPSRLAHLS
                     GKPWLNLGVYAGNSLQELIAAVPFFERADTVLVCSGINNVFASLQSLGTNELYGPLFFE
                     GALAALGRVPVPDLVAGQAAGAAPLGTAGDTRPEPKSLTTADLAARLDGALRRQLRDLA
                     VVAGAVRDGARLLFCLQPFADPVLRDPTPEERELYDLAQERQAAWTTARDYAAAHWESY
                     TERVAAGCERLGVDFFALPARAFSGFSFYDRVHMTDNGYRQAADMVWGKLCSNR"
     gene            complement(13823..15577)
                     /locus_tag="K2F47_RS35515"
     CDS             complement(13823..15577)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Carbam_trans_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014589.5"
                     /locus_tag="K2F47_RS35515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbamoyltransferase N-terminal domain-containing
                     protein"
                     /protein_id="WP_242910550.1"
                     /sec_met_domain="Carbam_trans_N (E-value: 6.4e-71,
                     bitscore: 234.2, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVILGISAFFHDSAAALLVDGELVAAAEEERFSRRKHDRDFPARA
                     IAFCLETAGVDARDVDYVAFYERPGLKAERALTTILAEAPATFGPFTRFLAEGGDRLNV
                     RRLISDAVGIEADRVLFVDHHLSHAASSFFASPFESAATLTVDGVGEWATSSVGEGAAS
                     WDGEGRNRLELKETLNFPHSLGLLYSAFTEFLGFRVNDGEYKVMGLAAYGTPRYREAIS
                     KVARLYDDGSLWLDMRYFRYHRSTRTGFHPRLADLLGVPPCPRDVELEPDEPGRRGELA
                     RRYADIAASLQRFTEDAVVAMARRAVEVSGQRRLCMAGGVALNGVANFQVLERAGVEEL
                     FIPSVPGDSGGSLGAALYVHHVLLGGPRRFVMRHASWGARHDDDAVARAVERAGLASER
                     HDDPAAITKITADLLANGGVGGWFQGRFEFGPRALGNRSILADPRGASMKDLINRKVKF
                     REPFRPFAPAMLHDRAPGYVAAPGAEQWPTRFMLLVMPLAEEFAASAPAVDHFGTGRIQ
                     TVSAEENPLFHSVIEQFQDRTGLGCVLNTSFNLRGEPIVATPQEAISTFERSGLDFLIM
                     EGHVISRP"
     gene            complement(15612..15785)
                     /locus_tag="K2F47_RS35520"
     CDS             complement(15612..15785)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS35520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242910551.1"
                     /transl_table=11
                     /translation="MNTLRRAVAIVVYCALVPVGVAIRLIADPLRVRRAPARSNWRRVP
                     QEPVSLERARRL"
     gene            complement(15782..17332)
                     /locus_tag="K2F47_RS35525"
     CDS             complement(15782..17332)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012706.5"
                     /locus_tag="K2F47_RS35525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_242910552.1"
                     /transl_table=11
                     /translation="MTENDDRRADAADVGRAGSLVEGWAEDVTTFNPVLAQDTFSQLAA
                     GLCFEPLVTSDAAGALVPALAEDVPQVEPDGRTYVFTLKDGLRWSDGSPLTSRDVVFTY
                     GLLGEGIGRLEEVSAPDDRHVVLRTTKPHAPFLVTHGQYGILPAHVLGDVAADRLADAP
                     FNALPDVVSGVFAPVRRTAGEEIVFRRNRSFHRGPCRLEEFVYRVFPDGAAVADGLASG
                     EVDVGLIDPFRMAELEAVPALDVVEIDLPTFNFYAHQLDLEKPAGRIFADRAVRRALLL
                     ALDREEIVKTAAHGQAVVAGSMMPPTSWAYDPAAKPEYPYDPERAAQLLDASGWRRGAG
                     GVRERDGRPLRFELLAGSNTRVWVDTAEAMRDAWRRLGADVALTLLDFPDLLTRVAERR
                     DFDVCMLAYTWGQDPDQSELFSSAAATDGFNCFGLSDPDVDEVLAAAVATFDRDERVRL
                     YRDYQRLMQELVPAPALFFMKGLYGINRRVSGYRVGTYNQFGARPWMADVSTRQGGGR"
     gene            complement(17351..18223)
                     /locus_tag="K2F47_RS35530"
     CDS             complement(17351..18223)
                     /NRPS_PKS="Domain: Abhydrolase_1 (24-274). E-value:
                     4.3e-21. Score: 67.6. Matches aSDomain:
                     nrpspksdomains_K2F47_RS35530_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012770.5"
                     /locus_tag="K2F47_RS35530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_242910553.1"
                     /sec_met_domain="PF00561 (E-value: 1.2e-18, bitscore: 62.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.4e-09, bitscore:
                     33.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEHRVVVGGRALWVVEAGDRAGTPVIMYHGTPGAPLFWDEWRDR
                     AAARGVRLVCYARPGYTGSSPAPGRTVADGAADCAAVADALGIDRFATWGVSGGGPHAL
                     AAAALLPGRVFAVATVGGLAPWDAEDLDVLDGMLEDNAAEVQAARAGDAALRELLEPTR
                     AAMAAGDRGALLGQLDAFLDDRDLEVARAGFGEVLVDGIRLGLRDGLDGWIQDDLAFAG
                     PWGFDPSEIACPAGVWHGGQDSMVPVAHAHWLAAHLKDAHVVVPGDAGHLAMVAYRMDE
                     VHEWLLRFR"
     aSDomain        complement(17402..18151)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K2F47_RS35530_Abhydrolase_1.1"
                     /evalue="4.30E-21"
                     /label="K2F47_RS35530_Abhydrolase_1.1"
                     /locus_tag="K2F47_RS35530"
                     /protein_end="274"
                     /protein_start="24"
                     /score="67.6"
                     /tool="antismash"
                     /translation="PVIMYHGTPGAPLFWDEWRDRAAARGVRLVCYARPGYTGSSPAPG
                     RTVADGAADCAAVADALGIDRFATWGVSGGGPHALAAAALLPGRVFAVATVGGLAPWDA
                     EDLDVLDGMLEDNAAEVQAARAGDAALRELLEPTRAAMAAGDRGALLGQLDAFLDDRDL
                     EVARAGFGEVLVDGIRLGLRDGLDGWIQDDLAFAGPWGFDPSEIACPAGVWHGGQDSMV
                     PVAHAHWLAAHLKDAHVVVPGDAGHLAM"
     misc_feature    18212..18228
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.48"
                     /tool="antismash"
     misc_feature    18279..18294
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.32"
                     /tool="antismash"
     misc_feature    complement(18281..18295)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.76"
                     /tool="antismash"
     misc_feature    18448..18462
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            18466..19122
                     /locus_tag="K2F47_RS35535"
     CDS             18466..19122
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (50-144). E-value: 1.7e-09. Score:
                     28.1. Matches aSDomain: nrpspksdomains_K2F47_RS35535_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009078473.1"
                     /locus_tag="K2F47_RS35535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_242910554.1"
                     /transl_table=11
                     /translation="MRSAYDAVAEEYAEKFAGELRGKPLDRALIEAFAHQVGALGPDAG
                     EPEIGDLGCGPGHTTRFVADLGLPVTGVDLSPRMVELAGRLYPGLEFREGSITALPVAD
                     GRWAGLLSLYSIIHLPPDLLPAAFSEFRRVLRPGGLLLLAFHIGDRRLHVDEWFGHTVS
                     LDGYLFEPAEIAALLEAAGFAVEAKVERCAYPGVEVATDRAYLFARRAAPGTTAH"
     aSDomain        18616..18897
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K2F47_RS35535_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.70E-09"
                     /label="K2F47_RS35535_oMT.1"
                     /locus_tag="K2F47_RS35535"
                     /protein_end="144"
                     /protein_start="50"
                     /score="28.1"
                     /tool="antismash"
                     /translation="DLGCGPGHTTRFVADLGLPVTGVDLSPRMVELAGRLYPGLEFREG
                     SITALPVADGRWAGLLSLYSIIHLPPDLLPAAFSEFRRVLRPGGLLLLA"
     gene            complement(19178..20599)
                     /locus_tag="K2F47_RS35540"
     CDS             complement(19178..20599)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013714.5"
                     /locus_tag="K2F47_RS35540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_242910555.1"
                     /transl_table=11
                     /translation="MAPDINWTPLAESLAGELILPEQAAYEWTRKPFIARFDDIEPAVV
                     VMCATPQDVAEALSFARRHDLEIALRSGGHCFAGYSSTRGMLINVTPMNDITVDAGTAK
                     VGAGTRIGAMTHALIDHGAVVPSGSCPSVGVGGTTLGGGIGILGRLFGLSCDHVTEAEV
                     VLADGRTIVTDHERDPDLLWALRGAGGGNFGVVTSLTFRTHPAPRMTNFFYEWDFEDAA
                     EVLKTWQRWAPAAPEEMTAGLGFTAMEDLAEPPIVELFGAMAGTESDTLKLLDDFVERI
                     GRPPAKTQCQEMSYRETAFYQAGLLSAVNNEVLETPTGVIERQGCRFTKSEFFARPVPD
                     EAIERLCAVFPVGRTPGEVRGLEIAPWGFGYARVDARASAFAHRDVSFSLKHAIMVPPN
                     AADGTKQDAHRWITGSWETVHPWGTGRVYPNFPDPDLSDWGSAYYGENFARLRQIKAAY
                     DPGNTFRFQQSIPVG"
     gene            complement(20608..21558)
                     /locus_tag="K2F47_RS35545"
     CDS             complement(20608..21558)
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024871.5"
                     /locus_tag="K2F47_RS35545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_242910557.1"
                     /transl_table=11
                     /translation="MRIDELAGLRIAVVDADEAVRTDWDACRPTGDVPSGEGIDLVRVL
                     DPPPGRWPDLAASGLLPRPDRVTWLAATGADDAGFLAGMSAKERQGITLARRRAAKAGL
                     TLSHEPLTPEALDTFLDLYEESVGEMPNGLAVARNHRDTIVAGIERFFIVGAYRDGVMQ
                     GAAIGECCADIGVARLRFSAVTAEHRRISLSRVLYLEAVRVVREAGYAKVTLGNDPNLY
                     GHLVMPGLFAFKARLGFRPVPSTTVNAGDGQDVADRVLSMRALADPSFALTYRDFRDRS
                     GRELRFDFYSVDGQADTGLFTTCMPADVHIHRVEG"
     gene            complement(21610..22131)
                     /locus_tag="K2F47_RS35550"
     CDS             complement(21610..22131)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS35550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242910558.1"
                     /transl_table=11
                     /translation="MTAAVYLVEAPDAADVLRDGAAHPVLGGLIDLGTSVRLTPGSALS
                     GPGADGAGTLRDAIAAVCADLEPKLTVLRRSGTLTADLRGELETRGAEHPVVVVLFLPG
                     DAALVVAAGPDLPAMGALPDGDLAALRASLLTVLGEPSGGDDFFSEPHFAFDDERERDL
                     NDRLRQLYGE"
     misc_feature    complement(22192..22205)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 22.38"
                     /tool="antismash"
ORIGIN
        1 gcgcgtatga cgaccagctc ctcgtggccc tgcccggggg acaggaggcc ccgggccgtc
       61 agcgactcgg cgcgtccccg cagcaccggg ccgaacggtt cgcggtgccg cgccaccacc
      121 gaggcccgca ggcccgcctg gcgcagcgcc accagcgtgg gctccacccc gttcagtgcc
      181 gaatgcacca tgagaagggt tcccgagggt gtcaggtggt gcggggccgc ctggcagata
      241 cggtccagca gcgtccggcc ctccgggccc gcctcccagg cgcgtgcccg gcctcgcacc
      301 gccgccgggt cgatgttgcc ggggacgtac ggggggttgg cgagaatcac gtcgaacgtc
      361 ttcccggcca ccggcgcgaa caggtctccg cgcagcactc gcatcggcag gccccgcact
      421 cgcgcgttga tccgcgccgt gaggaccgcc cagggcgaca cgtccaccgc gacgacctgg
      481 cagccccttc tcgcggccgc caccgcgacc gcgcccgttc cggtgcccag ttccagcaca
      541 cgggagcccg gcggaacggc ggcgccgcgc agtgccgccg tcagcagccg cgtatcggac
      601 tgcgggcggt agacgcccgg cgggcgcagc agcatcatcg gttctccgtc acttgccggc
      661 gcagcgccga gcggcctgat ctccaggatt ccagcaggtg ggcgccaagg cggtcctcca
      721 gcaggaccgt ggcccgcacg ccgaggacca cgtcggcggc cagctcgggc tcgtcggcga
      781 gcagcccgcc gatcacgtcg tggcgcagta cctgctcgtg gacggcgtcg gcctcgatgt
      841 gctccgtgta gaacaggcgg gcccgcgggc cgccgccgag ccgctccagc gccgccgcca
      901 tccgccgcgc ggacggcgcc gtcgtgatct ccgccgccgc gaagtggccc accagtgcgc
      961 cgcgcagcga ccgccgcagc ccgaacagcg acatcatgtt caccgtcgcc agcatcgccg
     1021 ccggcgccgc gtccacgtag gcgccgtagg acgggtccag ccccaggtcg tccagcaggt
     1081 cggcgtaaag gccctggtgg atcatctcgg gacggccgcc gccgaactcg tcgtgctcca
     1141 ccgccaccag cgccgtcttc gcctgccccc gcaggcgcgg caccacgaac gcgtgcgggt
     1201 cggcctcctt gaggtggtag accgaccgca gggccgcgtg ctccagcagt tgccagcccg
     1261 cgccgttgtc ccgcagatgg tggctgacgc cctccccgtc gaccggctcg gtcagcaggc
     1321 cctccagagc ctcctccacg tcggtgccgg ggacggtctc ccggcgcagc gcgtccagga
     1381 agaccgcctc catctcgccg cgcagccgga ggagccccgc gtcccactcc cagtccgcgt
     1441 cgaccccggc gaacccgcgg tagtgcagct cgtagcacat gtacagggcc agctgaagat
     1501 cgtcgccgaa gggatcggcc gccaccacgg cggcgaacag gtcgggcgag cggacgaacg
     1561 agcccggtgg gcccgccgtc agcgtgtcgg ccaccgtgcg cgagagcagg ccgcgggaag
     1621 ggggcggcgc cggagccctc ccccgctccg gggccccctc ggcgaaccgg cccggcacgt
     1681 gtcctacggt catgttccct ccgtgacctt gagattgtcc ggtttccggt acccgttaag
     1741 acacgtccca tacgtcgctc ttttcccacg tttgtcgcac tagaccgatg gagggaccgg
     1801 ggcgggtcgg ctgtcggcgc cgaggtgacg ggcgcagttc cgttcctggg ctgtgaccgg
     1861 tttgggctgg tcggcgaggg tatggcggag cgcgcgggca gacggcgatg cgatcacgcg
     1921 gcgaacatcg ggggatgtcg tgcgagtacg ttggcggcgg cgcgtgcgtg cgctgcgctg
     1981 gcccgtgggg atgggaatcg cgtcgtggcg gtggctgcgg cgctcccgcc aagtgagacg
     2041 gcgccgaatc cgcacgggga tactgtcgga ggccgaacgg atcccgcagc gcagcggagc
     2101 gcagacgcag cacgtgcgac agggcgtcgg actcacctac cagcgacgct acgtcgtcca
     2161 gatctccggc agccccatca gcgccgccca gctgatccaa cggctgggcg gtgatctcaa
     2221 cgccgcctcc ccggtggaga tcgccgtttt cgacaagacc tcgggaggct cccggcggct
     2281 ggaggtcggg gacgagtacg tggtccacat gccggggccg tggaactgcc cggtccgggt
     2341 ggtggaacgg acgcctgtgt cgttccggtt cgccaccctg cgcggccata tggaggccgg
     2401 tgagatcgag ttccgggtcg gcgacgcccg cgagggcgac ctggtgttca cgatcgagtc
     2461 ctgggcgcgc agcggcgacc ggttggcgga cctgctctac gagaaggtgg gcatcgcgaa
     2521 ggaaatgcaa tcgcacatgt gggcgcattt ctgtaggcgg gtcgccgaga tcgcggaagg
     2581 cgaggtagtc ggcgacgtcg aaatccagac agaacgaagc gacatgttca gggcccggag
     2641 cggaaaccag tcgatcaccc gtgcggtgga cgcggcgttc gcgcggagtt tcgccttggc
     2701 ggcgcgcttg cgaaaccggc ccctgcaccc gaggggcctg gtcttcgatg cccttttgcg
     2761 cctgcacggc acctcccagc accggggagt gccgttcctc gacgaccaca ccgaactccg
     2821 gggaagagcg cggctttcgc gcgcggtggg gttgccgccc ccgctgccgg acgtgctggg
     2881 cctcgcgctg cgctggccgc aaccgcaggc ggacctcacc ggtgaccatt ccactgccga
     2941 gttgctcctg gccgcgaccg ggcagaccgt gcccggccgt cacctgctgc ggccgatgac
     3001 caggtggagt cccgcgttct acggctccct cctgacgtac cgggtcggtg accgtcgcgt
     3061 cctgctgggc gcggtcgccc gccgcacacg catcgccccg gccgatctca cgactctcgc
     3121 gcgcgccgtg gacgagcggc cgctgctcct ggatctggtg gtggcgaccg agttcggccc
     3181 gtgggagccc ttcggcgaac taaggctcat cgggccggcg cgcagcgacg acctcgaacc
     3241 catgcgcttc aatcccgccc gccatcccat ccgggaactg cacccggaag ggctcctcca
     3301 gcgggcccgc ggctccagtt actcggccgt ccagcgcgtc gcccgccatg gcgccgatca
     3361 ccggccggaa aggccatcgt catgacgcgg aaggaacgcg cccggcagcg catgcgccga
     3421 cgccacgccg acctgcaccg gtgtcgtctc aacttcgatc cccggcagca cgacatgacg
     3481 aggcccgagc cgggttggaa tctcgacgac taccggcagc aactgccgcc ggaaccgccg
     3541 ggtcccccgg tccccggagg aagctgggag atcgcccgcc gcctcgtccg gggctaccag
     3601 tacgccgatc cgcgcatcat ccgcgagatc tgccgctcgg gcccgcccga gccgggccgg
     3661 gacatgctgc tcgaagcccg gttctacggg ctgcgcttcc acctcggcct acgggtcggc
     3721 gacgtcgtcg acacgaccat cgagcgggac gggcgccccg tgcgggtgtg gggctggaac
     3781 taccagaccc tggaggggca cctggaacgg ggtcagatgg accaggaggt gcgtaaatgg
     3841 ctcgacaccg gtgaggtgga attccatatc catgttttct cgcaagccgc gcccacaccc
     3901 cacccgatcg tccggctcgg cttcctgttc ttcgggcgat atatgcagct gaagttctac
     3961 aagcgggcgt gccggagaat gaaggccttg accgccgccg cactcggcgc cccgcgcgtt
     4021 tgcccggctg cctccgggta tcggccacgg atggaggaaa cccgttcccg gcagcttctg
     4081 ggcatctatc tcaacgacca tctcgccgca gcggcgggcg gtgtgggcct ggcctaccgg
     4141 ctcgcgcgag ggcatcgcgg ctcggacgac gccgagcagc tccgccggct ggccgacgac
     4201 atcgccgccg accggggcgc cctgctggcg atcctgaagt cgctcgggtt gccggcccgc
     4261 cgctacaaga gcgtcgcggt gtggacggcc gagaaggcgg ggcggctcaa actcaacggc
     4321 agcctgctcc gccgctcccc gctgagcgac gtggtggagc tcgaagccct gacccttgcg
     4381 gtccacggca aacgcgccgg atggcgcacc ctgctcgccg tcgccgaaca ggagcctgcc
     4441 ctcgacaccg agcatctgcg aaagctccag gcgcgcgcgg acgaccagct caccgtcctg
     4501 gagcggctcc ggacggcgac gagcgagaag gtgttccgcc agggacagcc cgcggcacag
     4561 tgaccgtcac cggaccccgc aacccgggtc agttgtgcac gcgactacgg ggatcggcaa
     4621 cgggcaggtc ctggccgtgg gccgcgaaga ggcgtgcggt gccgtcggcc agcccgtagc
     4681 acaggcccgc gacggcggcc tgcccggcgg cgacccgctc ggacagcagg cgggagcgat
     4741 ccagcagcag gtcgacggtg taccggatgt gctcggccag gatgtcctcc gcccgcacgc
     4801 tgccggcggc ccgcgcggcc agcacgctgg gcgtcacccg ctcgacgacg tcccgcacat
     4861 acccggacgg gggcaccccg ttctccagcg cggcgcacgc ggcgccgacc gcaccgcacc
     4921 cctcgtggcc cagcaccacg accagcgggg ctcccagctc gccgacgccg aactcgatgc
     4981 tgccaagcac ctccggcccc atcacgtggc cggcggtgcg caccacgaac aggtcgccca
     5041 gaccgcggtc gaagatgatc tcggcggcca gccgggagtc cgagcacccg aacagcacgg
     5101 cgaacgggcg ctgggacgcg gcgacctcgg tgcggcgcgc cgcgtcctgg ttcggatgct
     5161 cgggggtacc cgccacgaac cttctgttgc cggccagcag caactcgaaa gcggccttcg
     5221 gggacatggc ctcgatgtcg gtcatggccg aagcctacgg ccgcggcccc ctgccccgtt
     5281 ccatcagggt ccgctcgggc tacttgggcg gcatcaggac ggagtcgatg atgtagacgg
     5341 tggcgttggc ggtctggatg ttcccgcaca ccacgttcgc cttgccggtg ccgacggtga
     5401 aggagtctcc cgagccgctg gtgctgagcg tggcgccttg cagggtcgtg aagctgccgg
     5461 acggcaggcc gcccggcgcg atcttctggc cgacgacgtg gtaggtcagg atgcccttca
     5521 gcgtctcctt gtcggccatc accttgccga gcgtgccctt ggggatcttg gcgaaggcgt
     5581 cgttggtcgg cgcgaacacg gtgatgtgct gggcggagtt gagggtgtcg acgagccccg
     5641 cctgcttgac cgcgccgacc agcgtggaca gcacggggtt gttggacgcg gccgtcgcga
     5701 ccgggtcggc ggccatgccg ccgaagctgc ccttgccgga ggcggggacg gcggtgcacg
     5761 ccggtccgaa cggcttgtcc atcgcgggtg ccgccgcacc ggtggcggag ggcgccgccg
     5821 cgctgggcga ggcggtgctg gaggcgttgt cgtcgtcgcc ggagcaggcg gcgagtccca
     5881 cggtcaggac ggccgcggac aggacgccgg cggtgattcg tgtgcgcttc atggtgggct
     5941 cctctggatc ggatgaactg tcggtctcgg ctgaatgcgg ggtcggccgc tcggctcagg
     6001 tcacggtgac caccaccgag tgccagccgg tggccccgtc cgggaacggg ggtgtccggt
     6061 gctcgggctg ggtcgtcccg gtcccgtcga cggcgcggac gcggagggtg tgcgagcccg
     6121 gggaggcgtc ccattcggcg agccactgcc gccaggtgtc gattccgggc accggggcga
     6181 gccgcgccgg acgccagggc ccgtcgtcga cctgccactc gacggcgtcg atgccgcggt
     6241 gctgggccca ggcggtgccg gccacggcga cgggcccggc cttgaggcgc gcgaacggct
     6301 tggggacgtc gatgcgggag aacgtcttga cgggcgcgtg ttcggcgtag ccgcgcttgg
     6361 tccagtacgc ctggtcggta gcgaaccggg tcaccttgag atcgacgacc cacttggtcg
     6421 ccgacacgta gccgtagagg ccgggcacca ccatgcgggc gggaaaaccg tgcgcgaccg
     6481 gcagcggctc gccgttcatc cccacggcca gcagcgcgtc acgcccgtcc agcaccgcct
     6541 ccagcggagt gccgagggtc atgccgtcgg acgagcggga caggatctgg tcggcccccg
     6601 cccgtacccc ggcgcggcgg agcacggccg cgagcggcgc gccgagccag cgggcgctcc
     6661 cggccaggtc gccgccgacc tggttcgaca cgcacgcgag cgtgatgtcg cgttcgacca
     6721 gcgcctggcg cagcaggtcg tcgaaggtca actcgatcgg gcgggcgacc atcccgtgga
     6781 tccgcagcgt ccagtcccgg ggatcgacct ggggcaggac gagggcggtg tcgacccggt
     6841 agaaggcggc gttggacgtc cggaacgagg tcatgcccgg gacccgcacc tgcgcgcccg
     6901 gcgggaccgg cgcggccggg ctcaccgggg gcggcagtcg cagccgggcc cggacggcgg
     6961 agacgttccc gcgccgcagc agcgcccgcc ccccggcacc gctcaccgcc gccgcggccg
     7021 cgactccggc gccggtcagc agcgcacgcc gccggtcgtc cacccgggcc ggtccggcgc
     7081 cctcgcggga gcgtgccgcc agcagggtca gcgcggccat gccgcacgcg gcgccgacga
     7141 cggccgggac cgcgtcgacc aggtccgccg ccggacgggt cagggccgcg accacgccga
     7201 cgatcccgaa cgcggccagc cccgccgccc ctcggagcgg ccgcccgcgg ctcagcagcc
     7261 cgaccgcgac cgccgccatg gcggtcccgc agccgagccc ggccagcagg acggccttgt
     7321 cgtcgtcgcc gaaggtgcgg atcgcgaagt ccttcagccg gacgggggtg aggtcgatga
     7381 agcccgcgcc gacggcgagg atcggggacg cggtcgcccg tccgatggca ccggccgcca
     7441 gctcggcgct ccccagcgcg gcggccgcgg ccagcaggcc gtgcagcgcg gcggtgaccc
     7501 accgcaccgg cccggttact ccatcgcctg tcacactggg tgttcggtgc cgcgcggcga
     7561 gcggatggtg cgaatctttc cggacgaggt tcaccccatc cgcgccggct ccggcgccga
     7621 ataccgggtg tggagatgac tgatccgtcg agcggccgtg ccgcgccgtc cggcgtcccg
     7681 gacctgggcg agctgctttc ccaagtcgcc cggggcgacc gggacgcgtt cgagcaggtg
     7741 tacgagcggc tgtgcgggcc ggtgtacggg acggcgctgc gcgtcgtccg cgacccggcc
     7801 caggccgagg aggtcgccca ggaggtgctg gtcgaggtgt ggcgcaaggc gtcgcactac
     7861 cggccggacc ggggcagcgc cacggcgtgg gcgctgacga tggcgcaccg ccgcgcgatc
     7921 gaccgggtcc gctccgcgca ggccggccgg gtccgcgagg agcgggcggg cgtgcccgat
     7981 ccggactacg acgtggtcgc cgagcaggtc ggcacgcggc tggagcacca gcaggtgcgc
     8041 cgctgcctgc gcggcctcac cccgacgcag cgcgagtcga tcacgctggc ctactacggc
     8101 ggttacacct accgggaggt gtccgagctg ctgggcgtcg ggctcgccgc cgtcaagacg
     8161 cggatgcgcg acgggctgat ccggctgcgc gactgcctgg gagtccagtc atgacccacg
     8221 atccgcacca cctcgccgcc gcccacgccc tggacgcgct gccggacgcc gagcggcgcc
     8281 ggttcgaacg ccatctgtcc ggctgctcct cctgcgcgca ggaggtcgcc gggctgcggg
     8341 aggccaccgc ccggctggcg ctggccgcgt cccggcagcc gccgcccgcg ctgcgcgacc
     8401 gggtcctcgc cgagatcggc cggacgcggc agtcgccgcc gcgcctcgcc cgccggctgc
     8461 cgcccgcacc gagacgcggg ctgagctggc tcgccgccgc cgcgtgcctc gtgctcgccc
     8521 tcgcctgcgg gatcacggcg gtccacctgc acggcaccgc cgaacgcgcg cgggaggccg
     8581 accggcggat cgccgccgtg atgacggcgc ccgacgcccg gacgtccacc gcccggacgc
     8641 gggacggcgc cacggtcacc gtcgtgtcgt cccggtcgct cgaccaggcg gtgatcacca
     8701 cgtcccggct caggcggctg ccgccggcgc ggacctacca gctctggttc ctggccgcct
     8761 ccgccgctcc gcgctcgggc ggcgtcctac ggccacctgc ggacgggccg tcacagccga
     8821 tcatcgcctc cgggctcgga accgcgcagc aggtcggtat gaccgtcgaa cccgctggcg
     8881 gatccgcccg gccgtccacc gcccccttcc tcaccctccc gctgacctga gcaaccgatc
     8941 ccaggccacg agcacttcgg cctccttctc gggggtcatc cagggtttgt cctggcccgc
     9001 cctgcggccg tggtcgggtt cggatcgcag ccaccgccag gtgtcggcga ccgtgtcgtg
     9061 cacagggcgg cagtgcaggc cggcggcctt cgccttggtg gagtccacgc ggtagctggg
     9121 ttccaggacg ttgcccggcg ggatccagat cggcagctcc atccacggac gcaccccgtg
     9181 ggcgagcagg acgtcgccgt cgacccacgt cagatcggcg ccgccgcccg tcacggcgcg
     9241 gcaggcggcc aggagcgacg ccatggtggc gtgcccgacg tcggagagca cgttgaaatc
     9301 cccggcgagg ccgttctcct cggcgtccag gagccattcg gccaggtcgc gggtgtcgat
     9361 gtactggagg ggcaggtcgg agggccgggg cgccgccacc cggccgcccc gcgccacgcg
     9421 cagcagccac cacgggaggc ggcccgcgta ctcgtggggg cccaggatga ggccggtgcg
     9481 ggcgagcagg gcgcggtcac cgaacgcggc gcggacggcg tgctccccgc ccgccttggc
     9541 cagcgcgtac gagccgaaga tcccgccgga cgagccggag tcgggatcga gcagcggggc
     9601 gtcctcggtg aactcggcgg gcggcggcca cgcgtacact gccaggctcg acacgtaggc
     9661 gtaccggccg accgagggct ccagcgcccg cgcggcggcg gtgacggccg cggcgtcgtc
     9721 ccgccaggtg tcgatcacca ggtcccactc gcgtccggcg agcgcgcgca ggccgtccgg
     9781 gtcggtccgg tccccggtga gcgcttcggc gccggacggg ggcggtccgg tgacgcccct
     9841 gctgaacgtg gtcaccttcc agccgcgccg aagcgcggcg tccacgacgg cccgtccgac
     9901 gaaggcggtg ccgcccagca ccagcagccg cgtcatcgcg cgcccgccgt gtcgccgtcg
     9961 cagagcacag gggtctcctc gccgtcaccg catgcgcggt tcagttccag gtctggcacc
    10021 acatctccac ggaaagcagg ctgtacaagg gccagttggg gcctcgggtg aaaccgagcg
    10081 cggtgcgttg caggtcttcg agggcgggcc ccgggtcgac caggccgttc gcgacgcatc
    10141 tcccgtcgag gatcagttcg cggcacaggt cgcggtgcag ccgcagggag tgctggtaca
    10201 tgcccgcgta ggagcccttg ctccgcccgt cgacgacggc gcgcggcagc gttccggcca
    10261 tcgcgtcgcg cagcagcagc cggtcgccgc ggtggccgac cagcgaccgc atgggggcgc
    10321 ggagggcgag ttcgacgagc ggctgcgaca gcatggggta gacgctggga cggtgcgggt
    10381 tgcggtgctc ccggtccacc gcgtcacccc agtacaggat tcccgtcagc tggaacgccc
    10441 tggccgccga gagcccgtcg atgccgtcgg gcagccggag cgggctcggc ggggagtccg
    10501 gcgccagcca ggccgggcgc ggcgcgtcca gcatgccgtc ggggatggcg gtgccgcccc
    10561 ggattctccg cgccgtctcc gttcccacct cggcgagcag ggcgggcagg gaccgttcgg
    10621 ccagcgtgct ctcccgccac aactcccgca gcccgcccag cacatggccc gcgcccaggc
    10681 cgccgcccag caggtggtcg gcgtggtagc cgggcgtcga ccgcatgagg aagagctggt
    10741 cgccggcacc gccgctgagc gcctcggcgc cagggcccgc ctcctcggcg aggacctcgt
    10801 tcagccgggc ctcggcgtac tggagctgcg gcgcgtcggc gcggggcaag cggcccttcg
    10861 tgggggccag cgggaggcgg tcggcggcgt ccacgatcgt gagcggtgtc ctgaggaacc
    10921 gcgcgacgcg ttcggcggcg gggcgttcgt cgaccgaggc gccgagcggg aagcggacga
    10981 agcgcccgtg cagcgccgcc tcgtccgcga cgctgttgcg tgccgcccag cacacgctgg
    11041 aggagtcgag cccgccggac aggtccagcg ccaccgactc cgcctccgcg agccaggccc
    11101 gcgtgcagtc cagcagcgcg tgccggacct cgtcgggact gggcgcgtca ccgtccgcgc
    11161 acgcggccac cggatcccac agcggctccg acgtcgtgcg tccgtccgct atctggacga
    11221 cctcacctgg agagagctgc gcgacgcctt ggaacgccgt ccgatcagtg gggccggggc
    11281 ctcgcgtcat gaaggagccc agatgctccc agtcgaaccc cggtcgccgc cccagcagct
    11341 ctacgaggag ttccatacgg gtggcgaaga cgtgacccgt gccatgcggg gcgtagaaca
    11401 gcgggaggag gcctatcggg tcgcggatga ggacgagggc gccgtcgggc cggacggccg
    11461 ccgcggcgta ccgtccccac cgccgccgcg ccagctctcc tcgcggcgcc gcccagtcca
    11521 gcgggagggg gtcgcggcac ctgtgatcac ggcggccgtc cgcgctgtcg aagagtctgc
    11581 cggacaggag cccgcgcgtg acgtccccgg cgcggatctc caccggcgcg tcgtcgccgg
    11641 gcagcgtccc gccgccgacg gcggcgatca tccagccgtc gcccgcagcc cgcggcccat
    11701 cctcgcccgc cagctcccgc aggcgctgcg ccggtgccgc gtcgccgcga agaccgtgga
    11761 acccaacgag ggcgctcatg ggctcacctc tccggcgccg gcggtctccg ggccgatcac
    11821 caggatcggg gccagcgcgt cgacgacttc ctgcgcgtcg tcgaggacga cccggtgcag
    11881 ctccacgaac acccgcgtgt ggaacggata cttctgcact cccaggacga ggtgggccgg
    11941 aagccccatc cgccacgcgt gccgggccaa ggccgccgcg gctgacaagg ggttgctcgg
    12001 acgagcgagc aacccgcgga ccaccaggtg tgctctgacc agggtgcgcg cccggaccag
    12061 ctcgtccgag ccgggatcgc ccgcctgctc gggcagccgg ggacggcgcg cgtcccgcgg
    12121 gggcgtcagc aggccgtgcc gccggaggcg cccctcgctg tcggcgagca gccgcgccgc
    12181 gagggccagc gtcgccgggg tgggcggcgg cgccgagtgc gtgctcagac ccttaagcgg
    12241 ttgaggggcg aaggacgaca ccccgcccgg acgcgtcggc cgcacgggct cccagccggg
    12301 gtcggtcgaa gccgccgtga cgagcaggcc ccgggcgcac aatccgtcga ggatgcgccg
    12361 cgccgagggc gaggacggcg gggcctccga ggtcagcgct tcggacaccg cgccggaggc
    12421 ggcggagtcc agcgcgacga accggtcgga ggccaggtcg agggcgacga gctcgtcgtc
    12481 ccaccacgcc cagtggacgt ccggcgcgga acgcagcgcc gtgccgtccg ccgggtcggg
    12541 cggggcggac cgcgggacgg gattcaaccc ggcggggcac tcgacatggt gcggaaacgg
    12601 cgccgaatcg acggcctcaa gcacggtggc gcccttcccc ttcccgttca tatatcgcgt
    12661 actctccgtc ctaccagagc ggataggtgt tctcttccgg gacggcggcg tcctttccgg
    12721 gctgctcttt ctccggccgg gcaccggcgc cgccgtcggg tttcggggtc tcggtgccgg
    12781 gtccctttcg cgaccctccc ggaagcagga ccacgacgcg ggccaggcca cggatcatcg
    12841 gtttgagcac aatttccccc ataccatgtc ggcggcctgc cggtagccgt tgtcggtcat
    12901 atggacgcgg tcgtagaagg agaatccgga gaaggcgcgg gccgggagcg cgaagaagtc
    12961 gacgccgagc cgttcacagc ccgccgcgac gcgttcggtg taggactccc agtgcgcggc
    13021 ggcgtagtcg cgtgccgtgg tccaggccgc ctggcgttcc tgggccaggt cgtacagctc
    13081 gcgttcctcg ggggtcgggt cgcgcagcac cgggtcggcg aagggttgca ggcagaacag
    13141 caggcgcgcc ccgtcccgga cggcgcccgc gaccacggcc aggtcgcgga gctggcgccg
    13201 cagcgccccg tccaggcggg ccgccaggtc ggcggtggtc agcgacttgg gctcgggacg
    13261 ggtgtcaccg gcggtgccga gtggcgcggc accggcggcc tgccccgcga ccaggtcggg
    13321 aaccgggacc ctgcccagcg cggccagggc gccttcgaag aacagcggcc cgtacagctc
    13381 gttggtcccc agcgattgca gcgacgcgaa gacgttgttg atgcccgagc agacgagcac
    13441 cgtgtcggcg cgctcgaaaa agggaacagc ggcgatcagt tcctggaggg agttgcccgc
    13501 gtagacgccg agattgagcc acggcttgcc ggacaggtgg gcgagccgcg aaggcagggt
    13561 cgcctcgtca ctggtcgccc ccaccccgaa aacatacgat cctccgaggg cgatcccgcc
    13621 tccggactcg ggccagctcc gggtgtcgac gggcccctgc ggcgaggtcg acacccggaa
    13681 cccctccgcg tcggtgctga acacctcgcc ggtgatcccg ggccgggagc cgagcgtcat
    13741 gtaggggcgc aggtgcagtt cgttgccgtc gtagtcctcg aactgcggga ccagcgtgta
    13801 tcggcgtttc cggtgacccg cctcaaggtc gcgaaatgac atgaccctcc atgatcaaga
    13861 agtcgagtcc gctgcgttcg aaggtggaga tcgcctcctg cggagtggcc acgatcggct
    13921 cgccccgcag attgaacgag gtgttcagaa cgcacccgag tccggtcctg tcctggaact
    13981 gctcgatgac cgagtggaac agcggattct cctccgccga cacggtctgg atccggccgg
    14041 tgccgaaatg gtccacggcg ggcgcggacg cggcgaactc ctccgccagc ggcatcacca
    14101 gcagcatgaa ccgggtcggc cactgctccg ccccgggcgc ggcgacatag ccgggggcgc
    14161 ggtcgtgcag catcgccggg gcgaacgggc ggaacggctc ccggaacttc accttccggt
    14221 tgatgaggtc cttcatcgac gcgccgcgcg gatcggcgag gatgctgcgg ttgccgagcg
    14281 cgcggggccc gaactcgaag cgtccctgga accagccccc gacgccgccg ttcgcgagca
    14341 gatcggcggt gatcttcgtg atcgcggcgg ggtcgtcgtg gcgttcggag gccagcccgg
    14401 cccgctccac cgcccgcgcc acggcgtcgt cgtcgtgccg ggcgccccag ctcgcgtgcc
    14461 gcatgacgaa ccggcgcggc ccgccgagca gcacgtggtg gacgtacagc gccgccccga
    14521 gcgaaccgcc cgagtcgccc ggcacggacg ggatgaacag ctcctccacg cccgcgcgct
    14581 ccagcacctg gaagttcgcg acgccgttga gcgcgacgcc cccggccatg cacagccgcc
    14641 gctgcccgct gacctcgacg gcgcggcggg ccatggccac caccgcgtcc tcggtgaagc
    14701 gctggagcga ggcggcgatg tcggcgtacc gccgggccag ctcaccgcgg cggcccggct
    14761 cgtccggctc caactcgacg tcccgcgggc acggcgggac gccgaggagg tcggccagcc
    14821 gagggtggaa tccggtgcgg gtggaccggt ggtagcggaa gtagcgcatg tcgagccaga
    14881 ggctgccgtc gtcgtacagg cgggcgacct tggagatcgc ctcccggtac ctcggtgttc
    14941 cgtacgcggc gaggcccatc accttgtact cgccgtcgtt cacgcggaaa cccaggaatt
    15001 cggtgaacgc ggagtacagc agcccgaggg aatgcgggaa gttcagtgtc tctttgagtt
    15061 ccaggcggtt gcgaccttct ccgtcccacg acgccgcgcc ctcgccgacg ctgctggtgg
    15121 cccactcccc cacaccgtcg accgtcaacg tcgccgcgga ttcgaaaggc gaggcgaaga
    15181 acgaggacgc cgcgtgggac aggtggtggt ccacgaagag cacgcggtcg gcctcgatcc
    15241 cgaccgcgtc gctgatcagc cgccggacgt tcagccggtc cccgccctcc gcgaggaacc
    15301 gggtgaaggg accgaacgtg gcgggcgcct ccgcgaggat cgtggtcagg gcccgttccg
    15361 ccttgagccc gggacgttcg tagaaggcga cgtagtcgac gtcgcgggcg tccacacccg
    15421 ccgtttcgag gcagaacgcg atcgccctcg ccggaaagtc ccggtcgtgc ttgcgccgcg
    15481 agaagcgctc ctcctcggcg gcggcgacga gttccccgtc gaccagcagc gcggcggcgg
    15541 aatcgtggaa gaacgccgat atcccgagaa tcaccatctc tgttcctcgc cgccgggagt
    15601 gtgtggaccg ttcatagccg ccgtgcccgc tccagcgaga ccggctcctg gggcacgcgc
    15661 cgccagttgg accgcgcggg ggcgcggcgc acgcgcagcg ggtcggcgat cagccggatc
    15721 gccactccca ccggcacgag cgcgcagtag acgacgatcg cgaccgcgcg ccgcagcgtg
    15781 ttcatcggcc tcccccttgc cgcgtcgaga cgtccgccat ccaggggcgg gcgccgaact
    15841 ggttgtaggt gccgacgcgg tagccgctga cgcgcctgtt gatcccgtag aggcccttca
    15901 tgaagaagag cgcgggcgcc ggtacgagct cctgcatgag ccgctggtag tcgcggtaca
    15961 gccggacgcg ttcgtcccgg tcgaacgtgg cgacggcggc ggccagcacc tcgtccacgt
    16021 ccgggtcgct caggccgaag cagttgaagc cgtccgtcgc ggccgccgag gagaacagct
    16081 cggactggtc cgggtcctgc ccccacgtgt aggcgagcat gcacacgtcg aagtcgcgcc
    16141 gctcggcgac gcgggtcagc aggtcgggga agtcgagcag cgtcagcgcg acgtcggcgc
    16201 cgagccgccg ccaggcgtcg cgcatcgcct cggcggtgtc gacccagacc ctggtgttgg
    16261 acccggccag cagctcgaac cgtagcggcc gcccgtcccg ctcccgcacc ccgccggcac
    16321 cgcgccgcca gccggacgcg tcgagcagct gcgccgcccg ctcggggtcg taggggtact
    16381 ccggtttcgc ggcggggtcg taggcccacg acgtcggcgg catcatcgac cccgcgacga
    16441 cggcctggcc gtgcgcggcg gtcttgacga tctcctcccg gtccagcgcg agcagcagcg
    16501 cccgccgcac cgcccggtcc gcgaagatcc ggcccgccgg cttctccaga tcgagctggt
    16561 gggcgtagaa gttgaaggtc ggcaggtcga tctccacgac gtccagcgcg ggcaccgcct
    16621 ccagctccgc catccggaac gggtcgatca ggccgacgtc gacctcgccc gaggcgagcc
    16681 cgtcggcgac cgccgcgccg tccgggaaga cccggtagac gaactcctcc aaccggcagg
    16741 ggccccggtg gaacgaccgg ttgcggcgga agacgatctc ctcccccgcc gtgcgccgga
    16801 cgggcgcgaa cacgccgctg accacgtcgg ggagggcgtt gaacggcgcg tccgcgagcc
    16861 ggtcggcggc gacgtcgccc agcacgtggg cgggcaggat gccgtactgg ccgtgcgtca
    16921 ccaggaaggg cgcgtgcggt ttcgtcgtgc gcagcaccac atgccggtcg tcgggggcgg
    16981 acacctcctc cagacggccg atcccctcgc ccagcagccc gtaggtgaac acgacgtcgc
    17041 gcgaggtgag ggggctcccg tcggaccagc gcaggccgtc cttcagggtg aagacgtagg
    17101 tgcggccgtc gggctcgacc tgcggcacgt cctcggcgag cgcgggcacg agcgcgcccg
    17161 cggcgtcgga ggtgaccagc ggttcgaagc agagcccggc ggcgagctgg ctgaaggtgt
    17221 cctgggccag gacgggattg aaggtggtga cgtcctcggc ccagccctcg accaggcttc
    17281 cggcccgtcc cacgtccgcc gcgtccgcgc gccggtcgtc gttctcagtc atgtcgtctc
    17341 tcccccgagg tcagcggaac cgcaacagcc actcatggac ctcgtccatg cggtaggcca
    17401 ccatcgccag gtgcccggcg tcgccgggca cgacgacgtg cgcgtccttg aggtgcgccg
    17461 cgagccagtg ggcgtgcgcg accgggacca tggagtcctg cccgccgtgc cacaccccgg
    17521 ccgggcaggc gatctcggac gggtcgaacc cccacggccc ggcgaaggcg agatcgtcct
    17581 ggatccagcc gtcgaggccg tcgcgcagac cgagccggat gccgtcgacg agcacctcgc
    17641 cgaacccggc ccgcgccact tccaggtcgc ggtcgtccag gaacgcgtcg agctggccga
    17701 gcagggcgcc gcggtcgccc gccgccatcg cggcccgcgt cggctccagc agttcccgga
    17761 gcgcggcgtc ccccgccctg gcggcctgca cctcggccgc gttgtcctcc agcatcccgt
    17821 ccaggacgtc gaggtcctcg gcgtcccagg gcgcgaggcc gccgaccgtc gccaccgcga
    17881 acacccggcc cggcagcagc gccgcggccg ccagcgcgtg cgggccgccg cccgagacgc
    17941 cccaggtggc gaagcggtcg atgcccaggg cgtccgcgac ggcggcgcag tcggccgccc
    18001 cgtcggcgac agtgcggccc ggggccggcg acgacccggt gtatccggga cgggcgtagc
    18061 acaccagccg caccccgcgc gccgcggccc tgtcccgcca ctcgtcccag aacagcgggg
    18121 cgcccggggt gccgtggtac atgatcaccg gcgtgccggc gcggtcgccg gcctccacga
    18181 cccacagggc acggccgccc accacgacgc gatgttcttc catcacctgt tccactcgtt
    18241 cccactcgac gtcggttgcg gtcgcgcgga ccattgacaa tgaccacgaa tttccggtgg
    18301 ggcggccgag gcggcgtcat tgacgcgacc ggccgcgccg atagactggc ccggcccaga
    18361 cgatcgtgaa tgcgatggga agcagaccgt ccgatggacc tggaaagcga cacggaaaac
    18421 accggaaatc cggctgtgaa cggcggttcc gcaatttacg aaacggtgcg gtccgcctat
    18481 gacgcggtcg ccgaggaata cgccgagaag ttcgccggcg aactgcgcgg caaaccgctc
    18541 gaccgggcgc tcatcgaggc gttcgcccac caggtcgggg ccctgggccc ggacgccggc
    18601 gagcccgaga tcggcgacct cggctgcggg cccgggcaca cgacccggtt cgtcgccgac
    18661 ctcggcctcc cggtcaccgg cgtcgacctg tccccccgga tggtcgagtt ggccggccgc
    18721 ctgtacccgg ggctggagtt ccgcgagggc tcgatcaccg ccctgccggt cgcggacgga
    18781 cgctgggcgg gcctgctgtc cctctactcg atcatccact tgccgcccga cctgctgccc
    18841 gcggcgttca gcgagttccg cagggtgctg cggcccggcg gactgctgct gctcgccttc
    18901 cacatcgggg accggcggct gcacgtggac gagtggttcg gccacaccgt ctccctggac
    18961 ggctacctgt tcgagcccgc ggagatcgcc gcgctgctgg aggcggccgg tttcgccgtg
    19021 gaggccaagg tcgaacggtg cgcctacccg ggcgtcgagg tcgccaccga ccgcgcgtac
    19081 ctcttcgcgc gccgcgccgc gcccggcacc accgcgcact gacacccgcc cgcggacggc
    19141 cgccgcgcgg ccgcggttct ccgttccggg cggcatgtca gccgaccgga atcgactgct
    19201 ggaagcggaa cgtgttgccc gggtcgtagg ccgccttgat ctgcctcaac cgcgcgaagt
    19261 tctccccgta ataggcgctc ccccagtcgc tcagatccgg gtcggggaaa ttcgggtaga
    19321 cccgtccggt gccccacggg tggacggtct cccacgaccc ggtgatccac cggtgcgcgt
    19381 cctgcttggt gccgtccgca gcgttcggcg gcaccatgat ggcgtgcttg aggctgaagg
    19441 agacgtcgcg atgcgcgaac gcgctggccc gcgcgtccac cctcgcgtac ccaaaccccc
    19501 acggcgcgat ctccagcccg cggacctccc cgggcgtgcg gccgacgggg aacaccgcgc
    19561 acagccgctc gatcgcctca tcggggacgg ggcgcgcgaa gaactccgac ttggtgaacc
    19621 ggcagccctg ccgctcgatc accccggtcg gcgtctccag cacctcgttg ttgacggcgc
    19681 tgagcaggcc cgcctggtag aacgcggtct cgcggtagga catctcctgg cactgggtct
    19741 tggcgggcgg cctgccgatc cgctcgacga aatcgtccag cagcttgagc gtgtcggact
    19801 cggtgcccgc catcgcgccg aacagttcga cgatcggggg ctcggccagg tcctccatcg
    19861 ccgtgaagcc gaggcccgcg gtcatctcct ccggcgccgc cggggcccac cgctgccagg
    19921 tcttgagcac ctcggcggcg tcctcgaagt cccactcgta gaagaagttg gtcatcctgg
    19981 gcgcggggtg ggtgcggaag gtgagcgagg tgacgacgcc gaagttgccg ccgcccgcgc
    20041 cgcgcagcgc ccacagcagg tcggggtcgc gctcgtggtc ggtgacgatg gtgcggccgt
    20101 cggccagcac cacctccgcc tcggtgacgt ggtcgcagct cagcccgaac agccggccga
    20161 ggatgccgat gccgccgccg agggtcgtgc cgccgacccc caccgacggg cacgacccgg
    20221 acgggacgac cgcgccgtgg tcgatcagcg cgtgcgtcat cgcgccgatc cgcgtgccgg
    20281 cgccgacctt cgcggtcccg gcgtccacgg tgatgtcgtt catgggggtg acgttgatca
    20341 gcatgccgcg ggtggaggag tagcccgcga agcagtgccc gccgctgcgc agcgcgatct
    20401 ccaggtcgtg gcggcgggcg aagctgagcg cctcggccac gtcctgcggg gtggcgcaca
    20461 tgacgacgac ggcgggctcg atgtcgtcga agcgggcgat gaacggtttg cgcgtccatt
    20521 cgtaggcggc ctgctcggga aggatgagtt ccccggccag cgactccgcg agcggggtcc
    20581 agttgatgtc aggggccatg ggtcggctca tccttccacg cgatgtatgt gaacgtcggc
    20641 gggcatgcag gtggtgaaca gccccgtgtc ggcctgcccg tccacgctgt agaagtcgaa
    20701 acgcagctcg cgaccgctgc ggtcgcggaa gtcccggtag gtgagggcga agctggggtc
    20761 ggccagggcg cgcatggaca gcaccctgtc ggcgacgtcc tggccgtcgc cggcgttcac
    20821 ggtcgtggag ggcaccggac ggaaccccag ccgcgccttg aacgcgaaca ggccgggcat
    20881 caccaggtgc ccgtagaggt tcgggtcgtt gcccagcgtg accttcgcgt agcccgcctc
    20941 gcgcacgacc cgcaccgcct ccaggtacag cacccgggac aggctgatcc tccggtgctc
    21001 cgcggtgacc gccgagaagc gcagccgcgc cacaccgatg tcggcgcagc actccccgat
    21061 cgcggcgccc tgcatcacgc cgtcccggta ggcgccgacg atgaagaacc gctcgatccc
    21121 ggccacgatg gtgtcgcggt ggttgcgcgc gaccgcgagg ccgttgggca tctcaccgac
    21181 cgactcttcg tagaggtcga gaaaggtgtc cagtgcctcg ggggtgagcg gttcgtgcga
    21241 cagggtgagg ccggccttgg cggcgcgccg ccgggccagc gtgatgccct gccgctcctt
    21301 ggccgacatc ccggcgagga acccggcgtc gtcggcgccg gtggcggcga gccaggtgac
    21361 ccggtccggc ctcggcagca gcccggacgc ggccaggtcg ggccagcgtc cgggcggcgg
    21421 gtccaggacg cggaccaggt cgatgccctc gccggacggg acgtcgccgg tgggacggca
    21481 cgcgtcccag tcggtgcgga ccgcctcgtc cgcgtcgacc acggcgatcc gcagccccgc
    21541 cagttcgtcg atcctcaccc ggcaccgcct ccggcgcggt ccgcgcggtg gggcgccatg
    21601 ggcggctgct cactccccgt agagctggcg gagccggtca ttgaggtcgc gctccctttc
    21661 gtcgtcgaag gcgaagtgcg gttcgctgaa gaagtcgtcc ccaccggagg gctctccgag
    21721 gacggtcagc agactggcgc gcagcgcggc gaggtcgccg tcgggcagcg cgcccatcgc
    21781 gggcaggtcc gggccggccg cgaccacgag cgccgcgtcg ccgggcagga acagcacgac
    21841 gaccacgggg tgctcggcgc cgcgcgtctc cagctcgccg cgcaggtcgg cggtgagcgt
    21901 cccggaccgg cgcaggacgg tgagcttggg ctccaggtcc gcgcagacgg cggcgatcgc
    21961 gtcccgcaac gtgccggctc cgtccgcccc cggcccggac agcgccgagc cgggggtgag
    22021 gcggacggag gtgccgaggt cgatgagccc gccgagcacc ggatgcgcgg cgccgtcccg
    22081 caggacgtcg gccgcgtccg gtgcctcgac gaggtagacg gcggcggtca atggcacccc
    22141 ccgccgcagc tgccgcagcc gccgtcggtg ccgcacaccg aggccggcgc cttgatctgc
    22201 gtgaacccct cgcgggcgaa cagcagcccg gcgccgaggg cgtcgcggcc gagcgcgacc
    22261 atcaggatcc ggtccacgcc gatcgccgcg cccgacatcg gcggcatgcc cgcctccgcg
    22321 ctgatcatca gcgcctcgtt ggtcgcgacg tgcggcatgc cgctggcgac gcggtggctg
    22381 cgccgcgcgt cgtagcgggc gcgcagctcg gggccatcca cgaggttctc gtaggcgtgg
    22441 gccagctcca gccctcccgg gaagtacagc tcggagcgca gcgcgacccg ctcgtcggac
    22501 gggtcgagcc tggtgtgcag cgcgaggtcg gcggggaagt gcgtgaccca cagcggctgg
    22561 cgcaggccgg gcaggacgtg cgcgtccatc gcctcctcca gccaggcgcg ccgccacggc
    22621 accagcgggt cgggcagctt gatctcgcat c
//
