LOCUS       NZ_JAICDG010000003     25984 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinomadura terrae strain OS3-83 contig3, whole genome shotgun
            sequence.
ACCESSION   NZ_JAICDG010000003
VERSION     NZ_JAICDG010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura terrae
  ORGANISM  Actinomadura terrae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 1091803)
  AUTHORS   Lee,S.D., Yang,H.L., Kim,I.S., Choe,H. and Kim,J.S.
  TITLE     Actinomadura terrae sp. nov. and Actinomadura litoris OS3-89,
            isolated from rhizosphere soil of cactus
  JOURNAL   Int J Syst Evol Microbiol 73 (1) (2023)
   PUBMED   36748505
REFERENCE   2  (bases 1 to 1091803)
  AUTHORS   Lee,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2022) Institute of Jeju Microbial Resources, BioPS
            Co., Ltd., Sancheondan Dongil 16, Jeju 63243, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 141x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022751215.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:12:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,085
            CDSs (total)                      :: 8,002
            Genes (coding)                    :: 7,936
            CDSs (with protein)               :: 7,936
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 2, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 13 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 3 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 380014
            Orig. end                         :: 405998
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAICDG010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25984
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25984
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25984
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:15984](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15984)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(442..603)
                     /locus_tag="K2F47_RS21615"
     CDS             complement(442..603)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS21615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242906552.1"
                     /transl_table=11
                     /translation="MSQRNSTLSRHLTSEGTVIWSRCACGRLRMDLVPHGSAPRLTAGP
                     CARCHPPK"
     misc_feature    630..645
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.09"
                     /tool="antismash"
     misc_feature    662..678
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.04"
                     /tool="antismash"
     gene            677..1609
                     /locus_tag="K2F47_RS21620"
     CDS             677..1609
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017564011.1"
                     /locus_tag="K2F47_RS21620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_242906553.1"
                     /transl_table=11
                     /translation="MIDLRRLHMLRLVHQYGTVTATAEAMHLTPSVVSHHLRELARELG
                     VPLLEPQGRRVRLTPAAHLLIGHADALHARWEEALADLESHRAGVAGPLRICGFTTAVS
                     GLIAPAAGNLLRTDPDLSIEIRECDTDVAMGLLAAGETDLAVIEPTPDAPPPGDPRFDR
                     EPLLEEALDLIVPVGHPLARRDTARLEDAASEPWISVEPDGCAHHQQVMTYCAAAGFTP
                     RIAHNATTWSVIWALVASGLGVSLVPRLADGLSDQPVVRVPLTGDSVPKRRVLTCVRRG
                     SRANPVIARGLAALYEVVPSQCDRLPAAS"
     gene            complement(1613..4156)
                     /locus_tag="K2F47_RS21625"
     CDS             complement(1613..4156)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024116.5"
                     /locus_tag="K2F47_RS21625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_242906554.1"
                     /transl_table=11
                     /translation="MMVKLVFRGLAAHRARLLLSVVAVLAGVAFVSGTLIFSATLSRSF
                     DRAFDDLGRGTDTVVRARQSFQTGPGERAGSRPVPASALVAVRRAPGVAKAEGVVTGFA
                     AAVDRRGRIVGADPQIGVAWSGDRDLSLTRLTAGAPPRAPDEIAMDVTTARDAGYRVGD
                     RVTVALRSGKRTFRLTGLFRVGDSALGSSISMTAFAPGAAPRLLGQRPGTYERIVVHAD
                     GGVTQERLRDAVAAVLPPGLEAVTGEKAADEQAGPLQDIIKIMRTFLLVFALIAVFVGS
                     FIIFNTFAMLVGGRVRELALLRAVGASRGQVTRSILGEAAGVGLAGSTLGLAAGAGVAV
                     GLAKLMTLVTGGEELPFGPLALPASAVLAAYLVGTAVTLAAAFVPARRAARTPPVAALR
                     EDAAPPRPLRRRVLAGCAVLAIGAALAGAGLAGDGTSGLTLAGAGAALLFAGVVVVSPA
                     LSRPVTGVLGRPFARLRGGAGRMGARNATRDPRQTSATASALTIGLALIATVSIIVQSM
                     AASVDRQLDAALTADYQVTGRSQVTPVEAGAGAAVARVPGVRAAIPVRTARFRLDGAVR
                     TATTGSPGELLAHFRLPLQEGTAAVHGEDLLVGRSVARDHGWKVGSTIPGEYQDGTKRT
                     FHIAGIYADRPSLTPSAPTMIIDWAGYRAHDPDAPIDRVEVTVAGARRAALESALAPWP
                     NLELKDRAQVKDDAAGEIDLFLKLVLGLLVLSVLVAALGIVNTLALAVTERTREIGLLR
                     AVGTQRRQLRQMIRYEAVVVSLFGAVLGVGTGTVLGVVLQKAIAGGEDGMVVLAVPYGR
                     LALCVAAAASIGVVAAVWPAARAARLNILQAIATD"
     misc_feature    complement(4135..4149)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.72"
                     /tool="antismash"
     gene            4304..5593
                     /locus_tag="K2F47_RS21630"
     CDS             4304..5593
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="K2F47_RS21630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_242907518.1"
                     /transl_table=11
                     /translation="MTLPFTLPGRDRAADAVAVVLALALSLETATGPDSVLRGYGGATA
                     VVVAVPALALAVRRRFPMTVAWLTVALAALLDVVERLAPGALLREGAPGAFAPILWWPP
                     ALPFAAYAAMAFPRDTDRPVWVRGLPVAVLVPLVGLTQEVIPDGSIRRVSGQETSSVEV
                     MVFRGLVVLVAAALLGMYVAARRRVLAGLTERAERAERERHLLAERARTEERARLAAEM
                     HDVVAHRVTLMVLRAGALRVRAPDEETRAAADALRDDGCHALEELRDVIGLLRRDAGDA
                     GAAPAPASGPLPDLSALVAESAAVGVRVELVERGEPAPASPAVGRTAYRVVQEALTNAR
                     KHAPGAAVRVEARYRADGVRLTVLSAAPEREPDAALAALAASGSGTGLAGLRERVETVG
                     GTFSAGPSGDGFRVEASLPAYVPLPAPPAP"
     gene            complement(5560..6015)
                     /locus_tag="K2F47_RS21635"
     CDS             complement(5560..6015)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019656.5"
                     /locus_tag="K2F47_RS21635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1707 domain-containing protein"
                     /protein_id="WP_242906555.1"
                     /transl_table=11
                     /translation="MTTLDGTGVADLRVGDAERDAVMVALHDHFAAGRLDRAELDERLG
                     TTLAAKTRGDLEVIVRDLPDPKGLAVPKTAPARRERRHHHRGHRHGPPFPLLLGLFLVL
                     AFTMGPGTGFLVVLQVALALWVVRAILMTLRHRLAHRQGAGGAGSGT"
     gene            complement(6012..6812)
                     /locus_tag="K2F47_RS21640"
     CDS             complement(6012..6812)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631347.1"
                     /locus_tag="K2F47_RS21640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_242906556.1"
                     /transl_table=11
                     /translation="MGTTHRSGPDWRWAVAAAAIGAKAAHAASRHGHGHEHGFGPGHGH
                     GHGDARAHGGPWQWGPPGGFGPGGGRPPWGRGGGRGPWGRGRKAPKGNVRAAILALLAE
                     EPRNGYQIIQEIDERSGEAWKPSPGAVYPALQQLADEGLIVAEEAGGRRTYRLTAEGGA
                     YVAEHADELDEPWAQMAPDFGEGAPDLFRQVAQTGAAVMQIVHSGTPAQVRRATEIISE
                     ARRALYRVLADEEPHADEEPHAGEADAGPTDAGPTTGNSGEEPA"
     misc_feature    complement(6951..6971)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            7001..8983
                     /locus_tag="K2F47_RS21645"
     CDS             7001..8983
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025736.5"
                     /locus_tag="K2F47_RS21645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_242906557.1"
                     /transl_table=11
                     /translation="MGTDEAVTAPDAVVSRGGAVARGRLRGELLLGLAVFGLYALVVML
                     PQDARERAARGHGRALYDLERTLRLDVERTLNGWLAHQPVWRVLANYEYAITYIASAVA
                     LLSWLYLRHPERYRTARNAFLLINLVGIACFALYPVMPPRLMPELGFVDTVREGRTWGS
                     WGSPLVEHADRFAAVPSLHMAWTLWVGVELARVSARRWVQSLNAVHILLTLYVIMATAN
                     HYLLDAAAAVPLVGLAVYGAERAAPRGADERVRAPDAFFLAVETPEAPQHAGGLIVLDT
                     ARAPVTRADLVALVAARLGDHPRFRQRLADGGRWRRPVWRDHPAIDWAWHVQERRVDGM
                     AGLRAVVAELQSEPLPRDRPLWRMILLTGVAPGRDAVVFLMHHVVADGVGVVAHAMALM
                     EPHQLGYGAAGRRRRPVREALATAAGLGQLATDAARPARLPAAGTSERRFGSLLVPLDL
                     ARDVARRHGVRVTDVVLCAVAGGLHRVLRETPGAGDSCRVAVPLMMRSPGDGAEGNHTS
                     AVMVDLPLGKMAEADRLAEIARRTRVLRSGTRPLAAWFVMRHAGRVMPAPLHARFARYA
                     YSARFLQGIVSSLPGPDRRLRLAGAPLLEVYPVIPLAPGAPLAAGALGVDRDLCFGVCA
                     DPGLVPDADRMTDAIAEVVRELGAD"
     gene            complement(8996..10000)
                     /gene="hpnH"
                     /locus_tag="K2F47_RS21650"
     CDS             complement(8996..10000)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540959.1"
                     /locus_tag="K2F47_RS21650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_242906559.1"
                     /sec_met_domain="PF04055 (E-value: 5.9e-19, bitscore: 64.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.2e-08, bitscore: 30.5,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGMPLRQSLRVGGYILRNRLARRSKFPLLVELEPLYACNLACAGC
                     GKIQHPASLLKQRMPVEQAVAAVRESGAPMVSIAGGEPLMHPGIGEMVAELVAMKRYVF
                     LCTNAALIPKKIDQFEPSRFFAWAVHVDGLRERHDASVCKEGVFDQVVEAIRMCRERGF
                     RVTTNTTVFNTDTPQTVIDVLDYLNDDLRVDQMMISPAYAYEKAPDQEHFLGVQETREL
                     FRKVFADGRRRRWRFNHSPLFLDFLEGRADFPCTAWAIPSYSLKGWQRPCYLMDDGYAD
                     TYEELVKTTNWGAYGRGRDDRCSNCMAHCGYEPTAVFATMGSLTESLRAIRSG"
     misc_feature    9994..10010
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.52"
                     /tool="antismash"
     gene            complement(10001..11878)
                     /gene="shc"
                     /locus_tag="K2F47_RS21655"
     CDS             complement(10001..11878)
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540957.1"
                     /locus_tag="K2F47_RS21655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_242906561.1"
                     /sec_met_domain="T2TS (E-value: 3e-148, bitscore: 490.5,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTAEPAAPSTREAARKALDAAREHLLGLQSPEGWWKGELQTNV
                     TMDAEDLLLREFLGVRDEDETREAARWIRSQQREDGTWANFFGGPPDLSTTVEAYVALR
                     LAGDPPDAGHMRRAAAYVRDAGGLPATRVFTRFWLALFGRWPWDALPVVPPEMIYLPSW
                     FPLNVYDFGCWARQTIVPLTVVAALRPVRPLPFGIAELHGQAVPRRREGGWEEALHALD
                     RALRVYQRRPLKAVRRAALRRAGEWIIARQEPDGSWGGIQPPWVYSLIALNLLGHDVDH
                     PVMQRGLHGLERFTIRDGSGRRMEACQSPVWDTVLAMTALADAGLPPGHPALERAADWV
                     LGEEVKGPGDWQVRRPGLPPGGWSFEFDNDYYPDVDDTAEVVLALGRVAHPGAGPAIER
                     GLRWMAGMVSRDGGFAAFDADNTRELCRRLPFCDFGEVIDPPSADVTAHVVEALCAQGM
                     GDSLLCKRAVEWLLKAQEQDGSWFGRWGANHVYGTGGVVPALVAAGVRPDRPEIRRAVA
                     WLERHQRDDGGWGEDLRSYRDPAWIGRGASTASQTAWALLALLAAGERGPAVERGVGWL
                     TERQRPDGTWDEEHFTGTGFPGYFYINYHLYRLVFPVSALGRYLREDAS"
     gene            complement(11878..12870)
                     /locus_tag="K2F47_RS21660"
     CDS             complement(11878..12870)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634145.1"
                     /locus_tag="K2F47_RS21660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_272497377.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.4e-62, bitscore:
                     205.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVRELVDGALRAAVGRLDPHTYRVAAYHLGWADAEGRPRKEPA
                     GKALRPALALLSARAAGAPPESALPGAVAVELTHAFSLLHDDIMDGDRTRRHRPAAWAV
                     YGEPAAILAGDALLALAGEVLLEAPGQGSARAARSLAVATRHLIAGQSLDLSFETRHKI
                     TLEECQAMAAGKTAALLACSCSIGAVLDGAPERLATALEGFGADLGVAFQLVDDLLGIW
                     GDPAATGKPALSDLRSRKMSLPVVAALNSGTAASAELAELYARPEPPGEDELAEAARLV
                     DLAGGRAWARAEAARRVERAGEQLTGAGVPTPVRTEFLRVADFVTHRDH"
     misc_feature    12887..12902
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            complement(12888..14210)
                     /gene="hpnE"
                     /locus_tag="K2F47_RS21665"
     CDS             complement(12888..14210)
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634146.1"
                     /locus_tag="K2F47_RS21665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_242906565.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.4e-08, bitscore:
                     29.4, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 1.1e-11, bitscore: 40.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVVVVGGGLAGISAALALQESGMDVTLVEARPWLGGATHSFGRG
                     ELSVDNGQHVALRCCTAYQGLLRRLRTDHLMNIQARFDVTVLRPGEAPARLRRAPLPSP
                     LHLLPALARYAPLSPAERLRAVWAAAKIQSLDPGDPVLDGVAAGSWLAERGQRPWAREA
                     LWGLFVTAALNAEVDEAALGLSAMVCRRALFGRADAADIGVPSVPLAELHGAPALARIE
                     EAGGTVLLKAKVEAVTADPKVIVDGAPVAADAVVMAVPHDVAARLLPAEALPVPLRWPE
                     LGASPIVNVHVVYDRPVLGLPFVAAVGSPVQWVFDRTEVSGLRGDGQYLAVSLSAADRW
                     IDVPTAQLRERFTRELRRLLPAARHASVGDFFVTRERRATFRQRPGSGAARPGAATRAP
                     GLFLAGAWTDTGWPDTMEGAVRSGLTAARLVRRHLEGVRGR"
     gene            complement(14207..15124)
                     /gene="hpnD"
                     /locus_tag="K2F47_RS21670"
     CDS             complement(14207..15124)
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540950.1"
                     /locus_tag="K2F47_RS21670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_242906566.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.6e-58, bitscore:
                     192.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2.1e-65,
                     bitscore: 216.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVSETCERPEWVVEAYRHCERVVREEARNFGYGIRLMPTPKRRA
                     MSAIYAFARGVDDIGDGPEPACVRMDLLDRARGRLETVQEVLWRRADSRALEGHPVLTA
                     LADAAGRYPIPLDAFAELIDGCESDVRGAAYETFDDLLRYCQQVAGTVGRLSLGVFGYD
                     GRQRAEGLADSLGVAFQLTNILRDVREDRLAGRVYLPLEDLDRFGCTLELDGSGEFVDP
                     ASRLHDLVAFQAERARAWYAEGLRLLPLLDRRSAACTAAMAGIYRRLLERIAASPAVAL
                     NSRVSLPTWQKAVVAARALTGVEK"
     gene            complement(15121..15984)
                     /gene="hpnC"
                     /locus_tag="K2F47_RS21675"
     CDS             complement(15121..15984)
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634148.1"
                     /locus_tag="K2F47_RS21675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene synthase HpnC"
                     /protein_id="WP_242906567.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.7e-42,
                     bitscore: 141.5, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 3.7e-41, bitscore:
                     137.0, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTESPWSAREHERGLDGLARRENFPVATRLLPRRHRAHLRAVYG
                     FARLVDDIGDEAPGAWRAALLDSVDADLDLLYKGRAPVLPQLRRLADTVHARRIPAEPF
                     RRLVQANRQDQVVTRYASFDELVRYCVLSANPVGRIVLHVFGAQGRGLEEASDRVCTAL
                     QVIEHCQDVGEDFRAGRIYLPGEDLRRFGCAEDDLSRAVTPTRLRGVLALEAGRARDLL
                     DRGSAPLMAGLRGWARVAVAGYVAGGRAALAALVRGRYDVLARTPRPRAPVLLANWVST
                     LGEGER"
     misc_feature    complement(15724..15726)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16148..17080)
                     /locus_tag="K2F47_RS21680"
     CDS             complement(16148..17080)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016533.5"
                     /locus_tag="K2F47_RS21680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_242906569.1"
                     /sec_met_domain="APH (E-value: 3.2e-07, bitscore: 26.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPILPSPLPSVLIENAVEVWGDDGRRWLGRLPALVSEIAREWRL
                     EVETAGYELSYHWVAPVRREDGTKAVLKLGPPGPGHLAVEAAALETYGGEGAVRLLEHD
                     PARGALLLERAEPGVTLSELVPGKDEEATAVFVDVARRLRHAPPPGCVLPDLEKESASF
                     SGHLRRFPGDDPLPRHLVERAGRLFDELCASAPERLVLHGDLHHDNILSAEREPWLAID
                     PHGVVGDPGFEAGALFYNPDPDDRDERLVDLVPARIEQVADGLAMPVERVVAWAFVMAV
                     LSEVWRAQGDGTLGSRALDVALSLVNRLP"
     gene            17245..18063
                     /locus_tag="K2F47_RS21685"
     CDS             17245..18063
                     /NRPS_PKS="Domain: Abhydrolase_1 (22-127). E-value:
                     2.5e-21. Score: 68.3. Matches aSDomain:
                     nrpspksdomains_K2F47_RS21685_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887387.1"
                     /locus_tag="K2F47_RS21685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_242906571.1"
                     /sec_met_domain="PF00561 (E-value: 2.3e-18, bitscore: 62.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.8e-19, bitscore:
                     65.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDMGLEVVRRNNITVTGHEDGPVVMLAHGFGCDQNLWRLVVPEL
                     AERFRVVLFDHVGAGRSDLSAWDRDRYEGLDGYAGDVLEICQELELTEVTFVGHSVASM
                     IGVLAALREPERFAGLVLLVPSPCYIDDGDYRGGFSRDDIAELLDSLDSNYLGWSAAMA
                     PVIMGNPERPELGEELTNSFCRTDPVIARSFARATFLSDHRADLPGVTVPTLVVDCVQD
                     AIAPPEVGRYVTAQIPGSAQVTLPATGHCPQLSAPAATAHAIADFAGRPR"
     aSDomain        17311..17625
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K2F47_RS21685_Abhydrolase_1.1"
                     /evalue="2.50E-21"
                     /label="K2F47_RS21685_Abhydrolase_1.1"
                     /locus_tag="K2F47_RS21685"
                     /protein_end="127"
                     /protein_start="22"
                     /score="68.3"
                     /tool="antismash"
                     /translation="PVVMLAHGFGCDQNLWRLVVPELAERFRVVLFDHVGAGRSDLSAW
                     DRDRYEGLDGYAGDVLEICQELELTEVTFVGHSVASMIGVLAALREPERFAGLVLLVPS
                     P"
     gene            18063..19343
                     /locus_tag="K2F47_RS21690"
     CDS             18063..19343
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570412.1"
                     /locus_tag="K2F47_RS21690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_242906573.1"
                     /transl_table=11
                     /translation="MDRPRRGGEPADSEHARISSLLEDSAEDLYENAPCGYLSTLPDGR
                     IAKINRTLLDWLGYRREDLVGRRSFADLLTVGGRLYHETHFAPLLRMQGEIGGIALELR
                     AADGTRLPVMVTSTVKTGHDGEPQLIRTTVFDARDRRAYEQELLRARREAEQARAETDL
                     ERRRLHQLVATLQRTLLPPALPVVPGLDVAAHYHIASIDQVGGDFYDLFPLPGGRWGFF
                     LGDVCGKGAGAATATSLIRYTLRAAAQYDTDPRDVLSTLNAAVHAQYHGDGPRFCTVIY
                     GVLERRGDGFTATLASGGHPAALLIGGDGSARYQYSPDGMLVGIMDDAPFTATTIALRP
                     GDTLVLYTDGLTEAQIIAGGDSGDASEGRYGDQALLDFAASLAPTTAAEFVAAAIELLA
                     GFGDGLDDDTAILALSVPSGQAAGAVR"
     gene            complement(19852..20022)
                     /locus_tag="K2F47_RS21695"
     CDS             complement(19852..20022)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS21695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hydrophobic protein"
                     /protein_id="WP_242906575.1"
                     /transl_table=11
                     /translation="MVPLLLVLLLILILFGAGFALKILWWLAIAVLLIWLIGFVVRPSG
                     TGGRRGRWYRW"
     misc_feature    19984..19999
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.42"
                     /tool="antismash"
     gene            complement(20166..21030)
                     /locus_tag="K2F47_RS21700"
                     /pseudo=""
     CDS             complement(20166..21030)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611868.1"
                     /locus_tag="K2F47_RS21700"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRRHELTDAAWRGSSRCCPSRLLGVAGGWITGRC"
     misc_feature    complement(20988..21001)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(21835..21848)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     gene            complement(21952..22326)
                     /locus_tag="K2F47_RS21705"
     CDS             complement(21952..22326)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS21705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242906577.1"
                     /transl_table=11
                     /translation="MDGRSAAHRLRRGGMVAWERYRAWVTTANVTEADLTKEVVDDLVE
                     QASSTPPDPDHPVELTPTGHQIEAARTRKQWTRAVGSGLAAFVVVGSIAQLAVDAPLLL
                     AAAILGTAGWLWHLGRDEPK"
     misc_feature    complement(22955..22971)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.87"
                     /tool="antismash"
     misc_feature    23084..23099
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.38"
                     /tool="antismash"
     gene            complement(<23378..23692)
                     /locus_tag="K2F47_RS21710"
                     /pseudo=""
     CDS             complement(<23378..23692)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013777.5"
                     /locus_tag="K2F47_RS21710"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTHQTVGHERGPLADCPDSALVPPDRAPHCPIDITLAALAGRWTP
                     LVLREFLRRGEATYSELSAALPTLSDKVLSDRLTQLTNAGVIERHRTPGWPPRVRYTLT
                     P"
     misc_feature    complement(23663..23674)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     gene            23839..24576
                     /locus_tag="K2F47_RS21715"
     CDS             23839..24576
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000163: Decarboxylation (70% identity)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891690.1"
                     /locus_tag="K2F47_RS21715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_242906597.1"
                     /transl_table=11
                     /translation="MLIETDSDGLVLVDTGLGMADLRDPEERLGAEWVAFAEPGRDVAV
                     SAFQQVIGLGYAPQDVRHIVLTHLHRDHTGGLPDFPGAKVHVGDVEYRAVTDSAAPHHR
                     ESLERFMAAHRAHGPLLTPVSADERESWFGIQGVARPQGMECELVLVPLPGHSAGHSGV
                     AVRDGVGRWLLHAGDAYMYHGEIEETPPLSHPILDLVQDGAQTDVEARVNTRDRLRALR
                     RDHGDQVTVFSAHDPWEFARISD"
     gene            complement(24608..25204)
                     /locus_tag="K2F47_RS21720"
     CDS             complement(24608..25204)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS21720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242906599.1"
                     /transl_table=11
                     /translation="MARRTLIGACCLALITLTCGCSDSDGTASPKSPTSPSESAPGKAK
                     PAATDLNVWAIKFCLAVRSLGNVYIIDPPIDPDAADEAKLRKLFGTSRDALDIATKTAA
                     QIGPTGVSEADRLTDQLRRSLNTTGPRLTAELDAGSKAEGAKPSASVGKANKLLGTIHP
                     NSNDLFEAAQTQTEIGSVIKTTMGCPTQIIPLPTD"
     gene            complement(25233..25595)
                     /locus_tag="K2F47_RS21725"
     CDS             complement(25233..25595)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015928.5"
                     /locus_tag="K2F47_RS21725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase inhibitor family I36 protein"
                     /protein_id="WP_242906601.1"
                     /transl_table=11
                     /translation="MRVLGRISLAVSAAASVAVLPTSPASATTSGGIGDCPIASLCGWS
                     QPGFQGQMVTFRAGGGCQESPIPLRSVANTHRSAIDVVMTVYSGEECSGKDLGTVGRER
                     SLSTLPSAGFSVSSAW"
     gene            complement(25797..25979)
                     /locus_tag="K2F47_RS21730"
     CDS             complement(25797..25979)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.5"
                     /locus_tag="K2F47_RS21730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_242906603.1"
                     /transl_table=11
                     /translation="MATKWRKSTHSGTQGGSDCVEVGRFPQTVAFRDSKDPGGPKLVLS
                     QDAFAALVSELKQST"
ORIGIN
        1 tgtcggcgcg gggacggtcg tccggcccga ggacgccgag cggtcggcgg cggcgggcgc
       61 gaggttcctg gtcagcccgg gctgcacgcc ccgcctccag gcggcgatgg tcgcgacggg
      121 cctgccgttc ctgcccggcg tcgccaccgc gtcggaggcg atcgcgctgc tggagaacgg
      181 gatcacggcg atgaagttct tccccgccga ggccgcgggc ggccgcgcct acctgaaggc
      241 gctcggcggc ccgctgctcg acgcccgctt ctgcccgacc ggcggcgtca cccccggcaa
      301 cgccgccgac tacctcgcgc tgccgaacgt cggctgcgtg ggcgggtcgt ggcttacgcc
      361 tggggacgcc gtccgcgcgg gcgactggga ccgcatccgc gcgctcgccg ccgacgccgc
      421 cgccctcgga aagggctgac cctacttagg cgggtggcag cgggcgcagg ggccggcggt
      481 gagccggggg gccgagccgt gcgggacgag gtccatccgc agccgcccgc aggcgcagcg
      541 gctccagatg acggttcctt cgctggtcag atgccgggag agggtactgt ttcgctggct
      601 catgcaagca gtctgccccc gccggaacgt gcgcgtctat ttcacatttc cagatctgat
      661 cgtgcaatat ggtgacatga ttgatctgcg gcggctgcac atgctccggc tcgtccacca
      721 gtacgggacg gtcaccgcga cggcggaggc gatgcacctc acgccgtcgg tggtctccca
      781 ccatctgcgc gagctggcgc gggagctcgg cgtgccgctg ctggagccgc agggccgccg
      841 ggtgcggctc accccggcgg cgcacctgct gatcgggcac gcggacgcgc tgcacgcccg
      901 ctgggaggag gccctcgccg acctggagtc gcaccgcgcc ggggtcgcgg ggccgctgcg
      961 gatctgcggg ttcacgacgg cggtcagcgg cctgatcgcc cccgccgccg ggaacctgct
     1021 gcgcaccgac cccgacctga gcatcgagat ccgcgagtgc gacaccgacg tcgcgatggg
     1081 cctgctcgcc gccggggaga ccgacctcgc cgtgatcgag cccacccccg acgcgccgcc
     1141 gcccggcgac ccgcgcttcg accgggagcc gctgctggag gaggccctcg acctgatcgt
     1201 cccggtcggc catccgctcg cacggcgcga cacggcccgg ctggaggacg cggcgtccga
     1261 gccctggatc agcgtcgaac cggacggctg cgcccaccac cagcaggtca tgacctactg
     1321 cgccgccgcc gggttcacgc cccggatcgc ccacaacgcc acgacctggt cggtgatctg
     1381 ggcgctggtc gcgagcggcc tcggcgtgtc gctggtgccg aggctggccg acgggctgtc
     1441 cgaccagccc gtcgtccggg tgccgctgac gggcgactcc gtcccgaagc ggcgggtgct
     1501 gacgtgcgtc cgccggggga gccgcgccaa cccggtgatc gcccgcggcc tggcggcgct
     1561 gtacgaggtc gtcccctccc aatgtgaccg ccttcccgcg gccagctgac gctcagtcgg
     1621 tcgcgatggc ctggaggatg ttcagccgcg cggcgcgggc ggcgggccag accgccgcga
     1681 ccacgccgat cgacgcggcg gccgcgacgc acagcgcgag gcgcccgtag ggcacggcga
     1741 ggaccaccat gccgtcctcc ccgcccgcga tcgccttctg gaggacgacg ccgagcacgg
     1801 tcccggtccc cacgccgagg accgcgccga acagcgacac gacgacggcc tcgtagcgga
     1861 tcatctggcg gagctggcgg cgctgggtgc cgaccgcgcg cagcagcccg atctcgcgcg
     1921 tccgctcggt gaccgcgagc gcgagcgtgt tgacgatgcc gagcgccgcg accagcaccg
     1981 acagcaccag cagcccgagg accagcttga ggaacaggtc gatctcgccc gccgcgtcgt
     2041 ccttgacctg cgcgcggtcc ttcagctcca ggttcggcca cggcgcgagc gcggactcca
     2101 gcgcggcccg ccgggcgccc gcgaccgtca cctcgacgcg gtcgatcggc gcgtccgggt
     2161 cgtgggcgcg gtagcccgcc cagtcgatga tcatcgtggg cgcggacggg gtgagcgacg
     2221 gccggtcggc gtagatcccc gcgatgtgga acgttcgctt cgtcccatcc tggtattcgc
     2281 cggggatcgt gctgccgact ttccatccgt ggtcgcgggc gacgctgcgg ccgaccagca
     2341 ggtcctcgcc gtgcacggcc gccgtgccct cctggagcgg gagccggaag tgggcgagca
     2401 gctcgcctgg cgaaccggtg gtcgcggtgc gcactgcgcc gtccagccgg aacctggccg
     2461 tccggacggg gatcgccgcg cggacgcccg gcacccgcgc caccgccgcg cccgcgcccg
     2521 cctcgaccgg cgtgacctgg ctgcgcccgg tgacctggta gtcggcggtc agcgcggcgt
     2581 ccagctgccg gtcgaccgag gccgccatcg actggacgat gatcgagacg gtcgcgatca
     2641 gcgccagccc gatcgtcagc gccgacgcgg tcgccgacgt ctggcgggga tcgcgggtcg
     2701 cgttgcgggc gcccatccgc ccggcgccgc cgcgcagccg cgcgaacggg cggccgagca
     2761 cgccggtcac cggacggctc agcgcgggcg agaccaccac gacccccgcg aacagcagcg
     2821 ccgccccggc ccccgcgagc gtgaggccgg acgtcccgtc ccccgcgagc ccggccccgg
     2881 ccagggcggc gccgatcgcc agcaccgcgc atcccgcgag gacgcggcgc cgcagcgggc
     2941 ggggcggcgc cgcgtcctcg cgcagcgccg cgaccggcgg ggtccgcgcc gcgcgccgcg
     3001 ccgggacgaa cgcggcggcc agcgtcaccg ccgtccccac caggtacgcg gcgaggacgg
     3061 cggacgcggg cagcgcgagc ggcccgaacg gcagctcctc cccgccggtg accagcgtca
     3121 tcagcttcgc gagcccgacc gcgaccccgg cccccgccgc gaggccgagc gtcgagcccg
     3181 cgaggcccac cccggccgcc tcgccgagga tcgagcgcgt cacctgcccg cgcgaggccc
     3241 cgaccgcgcg cagcagcgcc agctcccgga cccgcccgcc gaccagcatc gcgaacgtgt
     3301 tgaagatgat gaacgacccg acgaacaccg cgatcagcgc gaacaccagc aggaacgtcc
     3361 gcatgatctt gatgatgtcc tggagcggcc cggcctgctc gtcggccgcc ttctcgccgg
     3421 tgacagcttc caggcccggc gggaggacgg cggcgaccgc gtcgcgcagc cgctcctggg
     3481 tcacgccgcc gtccgcgtgc acgacgatcc gctcgtaggt gccgggacgc tgccccagca
     3541 ggcgcggcgc ggcgccgggc gcgaacgcgg tcatcgagat cgaggagccg agcgcggagt
     3601 cgccgacccg gaacaggccg gtcagccgga acgtccgctt cccggagcgc agcgcgaccg
     3661 tgacccggtc gccgacccgg tagccggcgt cgcgggcggt ggtgacgtcc atggcgatct
     3721 cgtcgggcgc gcgcggcggc gccccggcgg tgaggcgggt cagcgacagg tcgcggtcgc
     3781 cgctccacgc cacccctatc tgcggatccg ccccgacgat cctcccccgc cggtcgacgg
     3841 cggccgcgaa cccggtgacg acgccctccg ccttcgcgac gccgggcgcg cgccggacgg
     3901 ccaccagcgc cgacgcgggc accggacgcg atcccgcgcg ctcacccggc ccggtctgga
     3961 acgactgccg cgcccggacg accgtgtccg tcccgcgccc gaggtcgtcg aaggcgcggt
     4021 cgaacgagcg gctcagcgtg gccgagaaga tcagcgtgcc ggagacgaac gcgacgcccg
     4081 cgaggaccgc caccaccgat agcagcaggc gggcgcggtg cgcggccagc ccacggaata
     4141 cgagcttcac catcatggcc acgattcgac cggtgcgggg tggggcggcg gcagggcgca
     4201 tcgtcgcctc cgcgttccgc ccgcgcccta cgaacggcag gccgcacccg actttcgtag
     4261 ggctcgcggg cggggaacgg gtgcgtacgg tgggcccgtg cgcatgacac tgccgttcac
     4321 gctccccgga cgcgaccgcg ccgcggacgc cgtggccgtg gtgctcgcgc tggcgctgag
     4381 cctggagacg gcgacgggcc cggactcggt cctgcgcggc tacggcggcg cgacggccgt
     4441 ggtggtggcg gtgcccgcgc tcgcgctggc ggtccgccgc cggttcccga tgacggtcgc
     4501 ctggctcacg gtcgcgctcg ccgcgctgct ggacgtcgtc gaacgcctcg cgcccggcgc
     4561 gctgctgcgc gagggcgcgc ccggcgcgtt cgccccgatc ctgtggtggc cgcccgcgct
     4621 gccgttcgcc gcctacgccg cgatggcctt cccccgcgac acggaccgcc ccgtctgggt
     4681 gcgggggctg ccggtcgccg tgctcgtccc gctggtcggc ctcacccagg aggtgatccc
     4741 cgacgggtcg atccggcgcg tctccgggca ggagacgtcc tcggtcgagg tgatggtctt
     4801 ccgcgggctg gtggtgctgg tcgcggcggc gctgctcggc atgtacgtgg cggcgcggcg
     4861 ccgcgtcctg gcggggctga ccgagcgggc cgagcgcgcc gagcgggagc ggcacctgct
     4921 cgccgagcgg gcgcggaccg aggagcgcgc ccggctcgcc gccgagatgc acgacgtcgt
     4981 cgcgcaccgg gtgacgctga tggtgctgcg cgcgggcgcg ctgcgggtca gggcgcccga
     5041 cgaggagacc cgcgccgccg ccgacgcgct gcgcgacgac ggctgccacg cgctggagga
     5101 gctgcgcgac gtcatcggcc tgctgcggcg cgacgccggg gacgcgggcg cggcccccgc
     5161 ccccgcgtcg gggccgctgc ccgacctgtc cgcgctggtc gccgagtccg ccgccgtcgg
     5221 cgtccgggtc gagctggtcg aacgcgggga gcccgcgccc gcctcgcccg ccgtcggacg
     5281 caccgcctac cgggtcgtcc aggaggcgct gaccaacgcg cgcaagcacg cgccgggcgc
     5341 cgccgtccgg gtggaggccc gctaccgcgc cgacggcgtc cggctgacgg tgctcagcgc
     5401 cgccccggag cgcgagccgg acgcggcgct cgccgccctc gccgccagcg gctccgggac
     5461 gggcctcgcc gggctgcgcg agcgcgtcga gaccgtcggc ggcaccttct cggcgggccc
     5521 gagcggggac gggttccgcg tcgaggcgtc gcttcccgcc tacgtcccgc tgccggcgcc
     5581 gcccgcgccc tgacggtgcg cgagccggtg cctgagcgtc atcaggatcg cccgcaccac
     5641 ccagagggcc agcgccacct ggaggacgac caggaacccc gtccccgggc ccatcgtgaa
     5701 cgccagcacc aggaacagcc cgagcagcag cgggaacggc ggaccatggc ggtgtccccg
     5761 gtgatggtgg cggcgttcgc gacgtgcggg cgccgtcttc ggcaccgcca ggcccttcgg
     5821 gtcgggcagg tcgcggacga tcacctcgag gtcgccgcgg gtcttggcgg cgagcgtcgt
     5881 gccgagccgc tcgtcgagtt cggcgcggtc gagccgtccg gccgcgaaat ggtcgtgcag
     5941 ggcgaccatg accgcgtcgc gctcggcgtc gccgacacgg aggtcggcga cgccggtgcc
     6001 gtccagggtc gtcacgccgg ttcctcgcca gagttcccag tggtggggcc cgcgtcggtg
     6061 gggcccgcgt cggcctcgcc cgcgtgcggc tcctcgtcgg cgtgcggctc ttcgtcggcg
     6121 aggacgcggt agagcgcgcg ccgggcctcg gagatgatct cggtggcccg cctgacctgc
     6181 gccggtgtcc cggagtggac gatctgcatc accgccgcgc ccgtctgcgc gacctgccgg
     6241 aacaggtcgg gcgcgccctc gccgaagtcg ggcgccatct gcgcccacgg ctcgtccagc
     6301 tcgtcggcgt gctcggccac gtaggcgccg ccctcggcgg tgagccggta ggtgcggcgc
     6361 ccgccggcct cctcggcgac gatcagcccc tcgtccgcga gctgctggag cgccgggtag
     6421 accgcgccgg ggctcggctt ccacgcctcg ccgctgcgct cgtcgatctc ctggatgatc
     6481 tggtagccgt tgcgcggctc ctcggcgagc agggcgagga tcgccgcgcg gacgttgccc
     6541 ttgggcgcct tgcgtccccg cccccatggg ccgcgcccgc cgccgcgtcc ccagggcgga
     6601 cggccgccgc cgggcccgaa cccgccgggc ggcccccact gccagggccc gccgtgcgcg
     6661 cgcgcatccc cgtgcccatg gccatggccc ggcccgaagc cgtgctcatg tccgtgtccg
     6721 tgccgggacg ccgcgtgcgc ggccttcgcg ccgatcgccg ccgccgcgac cgcccagcgc
     6781 cagtcgggtc cgctccggtg tgtcgttccc atgttcacca ccaccttctg agatctctct
     6841 atgatctctc gcgataggac aacgatatat cgaagacgta cggttcggga agatggttcc
     6901 cgcgaaagtc gcgcgtccgg cgcgtcgcgg acgcctcccg gatcgggcca tggtcgtctg
     6961 accggcggaa atactgggta accacccctg tggggggacg atggggacgg acgaggcggt
     7021 gaccgcgccg gacgcggtcg tgtcccgggg cggcgcggtc gcgcgcgggc gcctgcgggg
     7081 cgagctgctg ctgggcctgg cggtcttcgg cctgtacgcg ctggtcgtga tgctgccgca
     7141 ggacgccagg gagcgggccg cgcgcgggca cggccgcgcg ctctacgacc ttgagcggac
     7201 gctccggctg gacgtggagc ggacgctgaa cggctggctc gcccatcagc cggtctggcg
     7261 cgtcctggcc aactacgagt acgcgatcac ctacatcgcg agcgcggtcg cgctgctctc
     7321 ctggctgtac ctgcggcacc ccgagcgcta ccggacggcg cgcaacgcgt tcctgctgat
     7381 caacctggtc gggatcgcgt gcttcgcgct gtacccggtg atgccgcccc ggctgatgcc
     7441 cgagctcggg ttcgtcgaca cggtccggga gggccgcacg tgggggtcgt ggggatcgcc
     7501 gctggtcgag cacgccgacc ggttcgcggc cgtcccgtcc ctgcacatgg cctggacgct
     7561 gtgggtcggc gtcgagctgg cccgggtgtc ggcgcggcgg tgggtgcagt cgctgaacgc
     7621 cgtccacatc ctgctcacgc tgtatgtgat catggcgacc gcgaaccact acctgctgga
     7681 cgcggcggcc gccgtcccgc tggtgggcct cgcggtgtac ggcgccgagc gcgccgcccc
     7741 gcgcggcgcg gacgagcggg tccgcgcccc cgacgcgttc ttcctggccg tggagacccc
     7801 ggaggcgccc cagcacgccg gagggctgat cgtcctggac acggcgcggg cgccggtgac
     7861 ccgcgcggac ctcgtcgccc tcgtcgccgc gcggctcggc gaccatcccc ggttccggca
     7921 gcggctcgcg gacggcggcc ggtggcggcg gcccgtctgg cgcgaccacc cggcgatcga
     7981 ctgggcctgg cacgtccagg agcgccgcgt ggacggcatg gccgggctgc gcgccgtggt
     8041 cgcggagctc cagtccgagc cgctgccccg cgaccggccg ctgtggcgga tgatcctgct
     8101 gaccggcgtc gcgccgggac gcgacgccgt cgtgttcctc atgcaccacg tcgtcgccga
     8161 cggcgtcggg gtcgtcgcgc acgcgatggc gctgatggag cctcaccagc tcggctacgg
     8221 cgcggcgggg cgccgccgcc ggcccgtccg ggaggcgctc gcgaccgcgg cggggctcgg
     8281 gcagctcgcc acggacgcgg cgcgccccgc gcggctgccc gccgccggga cgtccgagcg
     8341 ccggttcggg agcctgctcg tcccgctcga cctggcccgg gacgtcgcgc ggcggcacgg
     8401 cgtgcgcgtc accgacgtcg tgctgtgcgc ggtggcgggc gggctgcacc gggtgctgcg
     8461 cgagacgccg ggcgcgggcg actcctgccg ggtcgcggtg ccgctgatga tgcgctcgcc
     8521 gggcgacggc gcggagggca accacaccag cgccgtcatg gtcgacctgc cgctcggcaa
     8581 gatggccgag gccgaccggc tcgccgagat cgcgcggcgc acccgcgtgc tgcggtcggg
     8641 gacgcgcccg ctcgccgcct ggttcgtgat gcggcacgcc ggacgggtca tgcccgcccc
     8701 gctgcacgcc cgtttcgccc gttacgccta cagcgcccgg ttcctccagg gcatcgtgtc
     8761 gagcctgccg ggcccggacc ggcggctgcg gctggcgggc gccccgctgc tggaggtcta
     8821 cccggtgatc ccgctcgcgc ccggagcgcc gctcgcggcc ggggcgctcg gcgtcgaccg
     8881 cgacctgtgc ttcggcgtct gcgccgaccc cggcctcgtg cccgacgccg accgcatgac
     8941 cgacgcgatc gccgaggtcg tccgcgaact cggcgccgac tagcccggga cggactcagc
     9001 cgctgcggat cgcgcgcagc gactcggtca gcgaccccat ggtcgcgaac acggcggtcg
     9061 gctcgtagcc gcagtgcgcc atgcagttgg agcagcggtc gtcgcgtccc cggccgtagg
     9121 cgccccagtt ggtcgtcttc acgagctcct cgtaggtgtc ggcgtagccg tcgtccatca
     9181 ggtagcaggg acgctgccag cccttcagcg agtaggacgg gatcgcccac gccgtgcacg
     9241 ggaagtcggc cctgccctcc aggaagtcca ggaacagcgg cgagtggttg aagcgccagc
     9301 ggcggcgccg cccgtccgcg aacaccttcc ggaacagctc ccgcgtctcc tggacgccga
     9361 ggaagtgctc ctggtcgggc gccttctcgt aggcgtaggc gggcgagatc atcatctggt
     9421 cgacgcgcag gtcgtcgttg aggtagtcga ggacgtcgat gacggtctgc ggggtgtcgg
     9481 tgttgaacac ggtcgtgttc gtcgtgaccc ggaacccgcg ctcgcggcac atccggattg
     9541 cctccacgac ctggtcgaac acgccctcct tgcagacgga cgcgtcgtgc cgctcgcgca
     9601 gcccgtcgac gtgcaccgcc cacgcgaaga accgggacgg ctcgaactgg tcgatcttct
     9661 tcgggatcag cgccgcgttc gtgcacagga acacgtaccg cttcatcgcg accagctcgg
     9721 cgaccatctc gccgatcccc gggtgcatca gcggctcgcc gcccgcgatc gacaccatcg
     9781 gcgcgccgct ctcgcgcacc gccgcgaccg cctgctcgac cggcatccgc tgcttcagca
     9841 ggctcgccgg atgctggatc ttcccgcagc ccgcgcacgc caggttgcac gcgtacagcg
     9901 gctccagctc gaccagcagc gggaacttcg agcggcgggc gagccggttg cgcaggatgt
     9961 agccgcccac ccgcaggctc tggcgtagtg gcatgcccat ttacgacgcg tcctccctca
    10021 ggtagcggcc gagggcgctc accgggaaca ccagccggta caggtggtag ttgatgtaga
    10081 agtagccggg gaacccggtg ccggtgaagt gctcctcgtc ccaggtcccg tcggggcgct
    10141 gccgctcggt cagccagccg acgccgcgct ccaccgccgg gccgcgctca ccggcggcca
    10201 gcagcgccag cagcgcccac gcggtctggg acgcggtgga cgcgccgcgt ccgatccacg
    10261 ccgggtcgcg gtaggagcgc aggtcctcgc cccagccgcc gtcgtcgcgc tggtgccgct
    10321 ccagccaggc caccgcccgc cggatctccg gccggtcggg ccggacgccc gccgcgacca
    10381 gcgcgggcac gacgccgccg gtcccgtaga cgtggttggc gccccagcgt ccgaaccagg
    10441 agccgtcctg ctcctgcgcc ttcagcagcc actccaccgc gcgcttgcac agcagcgagt
    10501 cgcccatgcc ctgcgcgcac agcgcctcca cgacgtgcgc ggtgacgtcg gcggacggcg
    10561 ggtcgatcac ctcgccgaag tcgcagaacg ggagcctgcg gcacagctcg cgggtgttgt
    10621 cggcgtcgaa cgcggcgaac ccgccgtcgc gcgagaccat cccggccatc cagcgcaggc
    10681 cccgctcgat cgccgggccc gcgcccgggt gcgcgacgcg gccgagcgcc agcacgacct
    10741 cggcggtgtc gtcgacgtcg gggtagtagt cgttgtcgaa ctcgaacgac cagcccccgg
    10801 gcggcagccc cgggcggcgc acctgccagt cgccggggcc cttcacctcc tcgccgagca
    10861 cccagtcggc ggcccgctcc agcgccgggt gcccgggggg caggcccgcg tcggcgagcg
    10921 cggtcatcgc gagcacggtg tcccagacgg gggactggca cgcctccatg cgccgccccg
    10981 atccgtcccg gatcgtgaag cgctccaggc cgtgcaggcc acgctgcatg accgggtggt
    11041 cgacgtcgtg gccgagcagg ttcagcgcga tcagcgagta cacccacggc ggctggatgc
    11101 cgccccacga cccgtccggc tcctgccgcg cgatgatcca ctcaccggcg cggcgcagcg
    11161 cggcccgccg caccgccttc agcgggcgcc gctggtagac gcgcagcgcc cggtcgagcg
    11221 cgtggagcgc ctcctcccat cccccctccc gccgccgcgg cacggcctgc ccgtgcagct
    11281 cggcgatgcc gaacggcagc ggccggacgg gacgcagcgc cgccaccacg gtcagcggca
    11341 cgatcgtctg ccgcgcccag cacccgaagt cgtagacgtt cagcgggaac cacgacggca
    11401 ggtagatcat ctccggcggc acgacgggca gcgcgtccca cggccagcgc ccgaacagcg
    11461 ccagccagaa gcgggtgaac acgcgcgtcg ccgggaggcc gcccgcgtcg cgcacgtagg
    11521 cggcggcgcg gcgcatgtgg ccggcgtccg gcgggtcccc ggcgagccgc agcgcgacgt
    11581 acgcctcgac tgtcgtggac aggtcgggcg ggccgccgaa gaagttcgcc cacgtgccgt
    11641 cttcgcgctg ctgggagcgg atccagcggg ccgcctcccg cgtctcgtcc tcgtcgcgga
    11701 cgccgaggaa ctcgcgcagc agcaggtcct cggcgtccat ggtcacgttc gtctggagct
    11761 cgcccttcca ccagccctcg ggggactgga ggccgagcag gtgctcgcgc gccgcgtcca
    11821 gcgccttccg cgccgcctcc ctggtggacg gcgccgcggg ttcggctgtc gtggtcatca
    11881 gtggtcccgg tgggtgacga agtcggcgac gcgcaggaac tcggtgcgga cgggggtggg
    11941 cactcccgcg ccggtgagct gctccccggc acgttccacc cggcgtgcgg cctcggcccg
    12001 cgcccacgcc cgcccgcccg cgaggtcgac gagccgcgcc gcctcggcca gctcgtcctc
    12061 gcccggcggt tccgggcgtg cgtacagctc ggccagctcc gcggacgcgg ccgtgccgga
    12121 gttcagcgcc gccaccaccg gcagcgacat cttgcgggac cgcaggtccg acagcgcggg
    12181 cttgccggtc gccgccgggt cgccccagat gccgagcagg tcgtcgacga gctggaacgc
    12241 gacgccgagg tcggcgccga acccctccag cgcggtcgcg aggcgctcgg gcgccccgtc
    12301 gagcacggcg ccgatcgagc acgagcaggc cagcagcgcg gcggtcttcc cggccgccat
    12361 cgcctggcac tcctccaacg tgatcttgtg gcgggtctcg aagctcaggt cgagggactg
    12421 gcccgcgatg aggtggcggg tggcgacggc cagcgaccgc gcggcccgcg ccgacccctg
    12481 ccccggcgcc tccagcagca cctccccggc gagcgcgagc agcgcgtcgc cggccaggat
    12541 cgcggcgggc tcgccgtaga cggcccacgc cgccggacgg tgccgccgcg tccggtcgcc
    12601 gtccatgatg tcgtcgtgca ggagcgagaa cgcgtgcgtc aactcgaccg cgaccgcgcc
    12661 cggcagcgcg ctctccggcg gcgcgccggc cgcgcgggcc gacaacaggg ccagcgcggg
    12721 acgcagcgcc ttcccggcgg gctccttgcg cggccgcccc tccgcgtcgg cccagccgag
    12781 atggtaggcc gccacccggt aggtgtgcgg gtcgagccgc ccgaccgcgg cgcgcagcgc
    12841 cccgtcgacc agctcgcgga catcggtcat cgagaccgga acggtcgtca ccggcccctc
    12901 accccctcca ggtggcggcg gaccaggcgt gcggcggtca ggccgctgcg cactgctccc
    12961 tccatcgtgt ctggccagcc cgtgtcggtc cacgcgccgg cgaggaacag ccccggcgcc
    13021 cgcgtcgccg cgccgggacg cgccgcgccg ctgccgggac gctggcggaa cgtcgcgcgc
    13081 cgctcccgcg tgacgaagaa gtcgccgacg gacgcgtgcc gcgccgcggg cagcagccgc
    13141 cgcagctcac gcgtgaacct ctcccgcagc tgtgccgtcg ggacgtcgat ccagcggtcg
    13201 gccgccgaca gcgacacggc caggtactgc ccgtcgccgc gcaggccgct cacctccgtc
    13261 cggtcgaaca cccactggac gggcgagccg accgccgcca cgaaaggcag ccccagcacc
    13321 ggccggtcgt agacgacgtg cacgttgacg atcgggctcg cgcccagctc cggccagcgc
    13381 agcgggacgg gcagcgcctc ggcgggcagc agccgcgccg ccacgtcgtg cgggacggcc
    13441 atgaccaccg cgtccgccgc gaccggcgcc ccgtccacga tcaccttcgg gtcggcggtg
    13501 accgcctcca ccttcgcctt cagcaggacg gtgccgcccg cctcctcgat ccgcgcgagc
    13561 gcgggagcgc cgtgcagctc cgccagcggg acggacggga cgccgatgtc ggccgcgtcc
    13621 gcccgcccga acagcgcccg gcggcacacc atcgccgaca ggccgagcgc cgcttcgtcc
    13681 acctcggcgt tcagtgccgc cgtgacgaac agcccccaca gcgcctcgcg cgcccacggc
    13741 cgctggcccc gttccgccag ccacgagccc gccgccaccc cgtccaggac ggggtcgccg
    13801 gggtcgaggc tctggatctt cgccgccgcc cacaccgccc tcagccgttc ggccggggac
    13861 agcggcgcgt accgggccag ggcgggcagc aggtgcagcg ggctcggcag cggcgcccgc
    13921 ctcagccgcg cgggcgcctc gccgggccgc agcaccgtca cgtcgaaccg ggcttggatg
    13981 ttcatgaggt ggtcggtgcg caggcgccgc agcagcccct ggtaggcggt gcagcagcgc
    14041 agcgcgacat gctggccgtt gtcgacgctc agctccccgc gcccgaacga gtgcgtggcg
    14101 ccgcccagcc aggggcgcgc ctccaccagc gtgacgtcca tccccgactc ctggagcgcc
    14161 agcgccgcgc tgatccccgc gaggccgccg ccgacgacga cgacgctcac ttctccaccc
    14221 cggtcagcgc gcgggcggcc acgacggcct tctgccaggt cggcagcgac acccgcgagt
    14281 tcagcgcgac cgccgggctc gccgcgatgc gctccagcag ccgccggtag atgcccgcca
    14341 tcgccgccgt gcacgccgcc gagcgccggt ccagcagcgg cagcagccgg aggccctcgg
    14401 cgtaccaggc ccgcgcccgc tccgcctgga acgccacgag gtcgtgcagc cgggacgccg
    14461 ggtcgacgaa ctcgcccgac ccgtccagct ccagcgtgca cccgaaccgg tcgaggtcct
    14521 cgaggggcag gtacacccgg cccgccagcc ggtcctcccg cacgtcccgc aggatgttcg
    14581 tgagctggaa cgcgaccccg agcgagtccg ccagcccctc cgcgcgctgc cgcccgtcgt
    14641 acccgaacac gcccagcgac agccgcccca ccgtccccgc gacctgctgg cagtaccgca
    14701 gcaggtcgtc gaacgtctcg tacgcggcgc cgcgcacgtc gctctcgcag ccgtcgatca
    14761 gctccgcgaa cgcgtccagc gggatcgggt accggcccgc cgcgtccgcc agggccgtca
    14821 gcaccgggtg cccctccagc gcccgcgagt cggcccgccg ccagagcacc tcctggaccg
    14881 tttcgagccg gccgcgcgcc cggtccagca gatccatccg gacgcacgcg ggctccgggc
    14941 cgtccccgat gtcgtccacg ccccgcgcga acgcgtagat cgcgctcatc gcgcggcgct
    15001 tcggggtcgg catcaaccgg atcccgtagc cgaagttgcg ggcctcctcc cggaccaccc
    15061 gctcgcagtg ccgatacgcc tccacgaccc actcgggccg ctcgcacgtc tccgaaaccg
    15121 tcatcgctca ccctctccga gagtggaaac ccagttggcg aggagcacgg gcgcgcgcgg
    15181 gcgcggcgtc cgcgccagca cgtcgtagcg gccgcgcacg agggcggcca gcgccgcgcg
    15241 ccccccggcg acatagcccg ccaccgcgac ccgggcccac ccgcgcagcc ccgccatgag
    15301 cggcgcggac ccgcggtcga gcaggtcccg cgcccggccg gcctccagcg ccagcacccc
    15361 gcgcagccgc gtcggcgtca ccgcccggga caggtcgtcc tcggcgcagc cgaaccgccg
    15421 caggtcctcg ccgggcaggt agatccgccc ggctctgaag tcctcgccga cgtcctggca
    15481 gtgctcgatc acctgcaacg cggtgcagac ccggtcggac gcctcctcca gcccccgccc
    15541 ctgggcgccg aacacgtgca gcacgatccg tcccaccgga ttggccgaca gcacgcagta
    15601 ccgcaccagt tcgtcgaacg aggcgtaccg ggtcacgacc tggtcctggc ggttcgcctg
    15661 gaccagccgc cggaaaggct ccgccggaat tctccgcgcg tggacggtat ccgccagtcg
    15721 ccttaactgc ggaagaaccg gagcccgccc tttgtagagg aggtccaggt ccgcgtccac
    15781 cgaatcgagc agcgccgccc gccacgcgcc cggcgcctcg tcgccgatgt cgtcgaccag
    15841 gcgggcgaaa ccgtagaccg cgcgcaggtg ggcgcggtgc cgcctcggca gcagccgggt
    15901 cgcgaccggg aagttctccc gtcgcgcgag cccgtcgaga ccgcgctcgt gctcccgcgc
    15961 gctccagggt gattcagtgg tcaccactag gggattcgcc ggtgcggcac cagaaaaact
    16021 ctgatcaagg tatggagtta ttgaaccgcc gtgcgtttcc gcgggtttcc gaggccgaaa
    16081 gggcgcgaca gaaaagtcgc ctttcgtggc aattagctgg ctatcggacg tgcctcgggg
    16141 cggcccgtca tggcagccgg ttcaccagac tgagggcgac gtccagcgcg cggctgccca
    16201 gcgtcccgtc gccctgcgcc ctccacacct ccgacaggac ggccatcacg aaggcccacg
    16261 cgacgacccg ctccaccggc atggcgagcc cgtcggcgac ctgctcgatc cgcgcgggca
    16321 ccaggtcgac cagcctctcg tcccggtcgt cggggtcggg gttgtagaac agcgcgcccg
    16381 cctcgaaacc ggggtcgccc acgacgccgt gcgggtcgat cgccagccac ggctcgcgct
    16441 ccgcgctcag gatgttgtcg tggtgcaggt ccccgtgcag gacgagccgc tcgggcgcgc
    16501 tcgcgcacag ctcgtcgaac agccgtccgg cccgctcgac caggtggcgg gggagcggat
    16561 cgtcgcccgg gaaacggcgc aggtggccgg agaacgacgc gctctccttc tccaggtccg
    16621 ggaggacgca tccggggggc ggcgcgtgcc ggagccgccg cgccacgtcg acgaacacgg
    16681 cggtggcctc ctcgtccttc ccggggacga gctcgctcag cgtcaccccc ggctcggcac
    16741 gttccaacag cagcgcgccc ctggcgggat cgtgttccag cagcctgacc gcgccctcgc
    16801 cgccgtaggt ctccagggcc gccgcctcga cggccagatg gcccggtccg ggcgggccga
    16861 gcttcaggac cgccttcgtc ccgtcctccc gccggacggg cgcgacccag tggtagctca
    16921 actcgtaccc ggcggtctcg acctccagcc gccactcgcg ggcgatctcc gagaccagcg
    16981 cgggcagccg ccccagccag cggcgtccgt cgtcccccca gacctcgacg gcgttctcga
    17041 tcaggacgga ggggagcgga ctgggaagaa tcggcgacat cccccaaccc tggcagagcg
    17101 ggcggtagat cgccgacggg atgtgacaac cccctggtcc cctgagctcc cggcggccga
    17161 tcaccgccgg acgcgtaggg cgacgcccgg atcggggacc gtctcctggt ccgggtgtcg
    17221 gtggtggggg gcgggggtgc gagtatgggt gatatggggc tggaggtggt gcgccgcaac
    17281 aacatcacgg tcaccgggca tgaggatggt ccggtggtga tgctcgcgca cgggttcggg
    17341 tgcgatcaga acctatggcg gctggtggtc cccgaactgg ccgagcggtt ccgggtggtg
    17401 ctgttcgatc acgtgggcgc ggggcgttcg gatctgtcgg cgtgggatcg cgaccggtac
    17461 gagggcctgg acggatacgc cggggacgtg ctggagatct gccaggagtt ggaactgacc
    17521 gaggtgacgt tcgtagggca ctcggtggca tccatgatcg gtgtgctggc cgcgctccgc
    17581 gaaccggagc ggttcgccgg gctggtgctg ctggtgccct ccccgtgcta catcgatgac
    17641 ggcgactacc ggggcgggtt cagccgggac gacatcgccg agctgctgga ctcgctggac
    17701 agcaactatc tggggtggtc ggcggcgatg gctccggtga tcatggggaa tcccgagcgt
    17761 ccggagttgg gcgaggaact gaccaacagc ttctgccgga ccgacccggt catcgcccga
    17821 tccttcgccc gggcgacgtt cctgtccgat caccgggcgg atctgccggg cgtcaccgtg
    17881 ccgaccctgg tggtggactg cgtccaggat gccatcgcgc cgcctgaggt cggccggtac
    17941 gtcaccgcgc agatccccgg cagcgcccag gtcactctgc cggctaccgg ccactgtccc
    18001 cagttgagcg cgccggcggc caccgcccac gccatcgcgg actttgccgg cagaccgcgg
    18061 tgatggaccg gccccggcgc ggcggcgaac ccgccgactc agagcacgcg aggatctcct
    18121 cgctgctgga ggacagcgcc gaggaccttt acgagaacgc gccctgcggc tacctgtcga
    18181 ccctgccgga cggccggatc gccaagatca accgcaccct gctggactgg ctgggctacc
    18241 ggcgcgagga cctggtcggg cgccggagct tcgccgacct gctcaccgtc ggcggccgcc
    18301 tctaccatga gacccatttc gcgccgctgc tgcgcatgca gggcgagatc ggcggcatcg
    18361 cgctggagtt gagggccgcc gacggtaccc ggctcccggt catggtcacc tccacggtca
    18421 agaccggcca cgacggtgaa ccgcagttga tccgcacgac cgtcttcgac gcccgggacc
    18481 gccgcgccta cgagcaggag ctgctgcggg cccggcgcga agccgagcag gcacgcgccg
    18541 agacggacct ggagcgtcgg cggcttcacc aactggtcgc caccctgcaa cggacgctgc
    18601 tgccgcccgc actgccggtc gtccccggcc tggacgtggc cgcgcactac cacatcgcct
    18661 cgatcgacca ggtcggcggc gacttctacg acctgttccc actgcccggg ggccggtggg
    18721 ggttcttcct gggtgatgtg tgcggcaaag gggccggagc cgccacggcg acctccctca
    18781 tccgctacac ccttcgcgcc gccgcgcagt atgacaccga ccctcgcgac gttctgagca
    18841 ccctcaacgc cgccgtccac gcccagtacc acggggatgg tccgcgcttc tgcaccgtca
    18901 tctacggggt cctggaacgt cgcggtgacg gcttcaccgc gacgctcgcc agcggcgggc
    18961 atcccgccgc actgctgatc ggtggcgacg gtagcgcccg ataccagtac agcccggacg
    19021 gaatgctggt cgggatcatg gacgatgcgc cgttcaccgc gaccacgatc gccctgcggc
    19081 ccggcgacac cctggtcctg tacaccgacg gcctgaccga agcccagatc atcgccggcg
    19141 gtgattccgg cgatgcctcc gagggccgct atggagacca ggccctgctg gacttcgccg
    19201 cgagcctcgc gcccaccacc gcggccgagt tcgtcgcggc cgcgatcgaa ctgctcgccg
    19261 gcttcgggga cggtctggat gacgacaccg ccatcctcgc cctctcggtc ccgagcggtc
    19321 aggcggccgg ggcggtccgg tgaaccccct cagcgtcacc gggaccgggc ccgtcctgtc
    19381 acctggacgt cggttcagcc gaccgtccgc cgcgtgaggc cagatcagca gctcatcctc
    19441 gatctgggcg gggtgaccct ctgcggctcc agcgggatcc cttcatcgcc gcgcgcgacc
    19501 tcacccacgc cgcgctgggc ctcaccaccg ttccggaccg tatccggcgc gtcctctgcg
    19561 ccgtggggct ggaccgggtc ccaactctgc acccgacttt ctccgccgcc tccgcccggc
    19621 cgacggactg gctgagtatt tttgtgagtt cccgggcatt tgaggggacg tgccaggagg
    19681 tccttgaatg cctggctctg caccgttgag aagccagagt acgccgcgtc gctgatgtcc
    19741 ttcgtctcag atgggcgagt aatcctcaag gaacagaggc agaggaacgc cgttggcggc
    19801 gtgcctctcg catcggggtt cgggtccatt tgtggagggt gtatcaggtg gtcaccatcg
    19861 gtaccagcgg ccgcgtcgcc caccggtgcc ggaggggcga acgacaaagc cgatcagcca
    19921 gatcaagaga accgcgatcg cgagccacca gaggattttc agcgcgaaac cggcgccgaa
    19981 caggatgaga atgagcagca gaaccagtag cagcggaacc atgcgtctta cctcccggcg
    20041 ccgatatgcc ccgccgtcgc caatgtattc cgggaactcg ccgcccgccg ccgcgacgac
    20101 cggggccgcc gagccgcgcc tccccggtaa tgctccccag taacccctag ggcgtgtccg
    20161 gtggatcatg tgttgatcca gagcagtgct gtgaccagga cgatcgctgc gcggtagttg
    20221 cgggcgagtg tgtcgtagcg ggtggcgatg ccgcgccatt gcttgaggcg tccgatgcag
    20281 cgttcgacca cgttgcggcg gttggagagg gctgggtcga agaccggtgg gcgtccgccg
    20341 tgtgagccgc ggcgcaggcg tccggcctgc tggtcgacgc gttcggggat ggtcgcggcg
    20401 atccctcgtg cgcgcagtga ccggcggatc gcggccgagc tgtaggcctt gtcggcgatc
    20461 acccggtcgg gccggcggcg ggggcgaccc cgaccaggcc gcggcacggc gatcgccgcc
    20521 aggacctggg tgaaggcggt gcagtcgttg acgttcccgg gtgtgagcac gatcgacagc
    20581 ggcaggccgc gtccgtccac gctcgggtgg accttggtgg acagccctcc ccgggagcgc
    20641 cccagtgcct gcccggctgc cgctgccctg ttcgtcccgc ccggttcccc tttttgcggc
    20701 ccccggcggc gtgctggtgg gcgcgcagga tggtggaatc gacactgacc gtccagtcga
    20761 taccgccgac cgcatcgtca tgcacctgca cgtggctcaa gaccgcatcg aaggtgccat
    20821 cggctgccca ccgccgatac cgctcatagt cggtcttcca gttgccgtac cgctcgggca
    20881 ggtcccgcca cggcgcaccg gtcgccaact tccacaagat cccgttcagc accgtccggt
    20941 gatccaacca ccggccaccc cgagcagcct ggacgggcaa caacggctcg atccgcgcca
    21001 agcggcatcg gtgagctcat gacgacgcac catgcccacc atcacaaccc aggacacaaa
    21061 tcagcctcag ccaaacaccc agatccaccg gacaggacct aggggccgac gtctggcccc
    21121 caaggggtga tgatccgagg cggtggtacg cgccccgcgc cagggcgcca aactgatctc
    21181 gaagcaggga caggacgagg tcgtctcacc gaagtcggcc ccttctggtc agccccactt
    21241 tcacggcgct gtaaccgccg cctgggttcc tttgctgagt ggcgaccgcc gcggccgggt
    21301 cgcaactcca actggtcgtg aaggacacct ttcccgtgct gtcccacttg tccacgacat
    21361 agggcaggcc accatcgagc gtgcagatcg gcccggcccg gactggtgtg ataagggctc
    21421 cgtatcgctt tggcgcctgg acggcgactc cattgcgggt gccctcctcg caaccggggg
    21481 ctcgcaatag atggcggcat gcgacgttgc ccgtggtgga ttgtcgcggt ggtcggcggg
    21541 gaccgtgcga gcagcggggg tgtggaggcg tgcacgagcc agaggccggt gccagttggg
    21601 ctgttcgctt ggttcgtagg gcggtgtgga ggtaggcgac cttcttcagc gacacgccag
    21661 gctcgacagc acgaccggcg gctcgctgaa aaatccgctc cgggcgacct tctcttacct
    21721 tcacgcacct gcgctctact ctgggctcat cacccctgcg agggttcgca acatcctgct
    21781 gttcgacgac ccctacgcca tctgggcacg tgctcatcgc ccctgagagg gtttgcaacc
    21841 ggagtgcctg gacaaggatc gtctccgcag cgtgtcctca tcgtcttgag agggggcaga
    21901 acgggtggct ttgccatcgg agggcaccgc acgtcagcgg gcctaatcgc actacttggg
    21961 ttcgtcgcgc cccaggtgcc atagccatcc ggcggtgcct agtattgcgg ccgccaagag
    22021 gagcggggcg tccacggcga gttgcgcgat gctgcctacc acgacgaatg ccgccaggcc
    22081 gctgcccacg gcccgtgtcc actgcttccg cgtgcgggcc gcttctatct ggtgcccggt
    22141 cggggtcagc tcgaccggat gatcagggtc gggtggcgtg gacgacgcct gttccaccag
    22201 gtcatcgacc acctctttgg tcaagtcggc ctcggtgacg ttcgcggtgg taacccaggc
    22261 gcgatatctc tcccacgcca ccatgccgcc tcggcgcagg cggtgggctg cactcctgcc
    22321 gtccacgtca gggctccgtt ctcgtctgcc gaacgcgagt ggcgcttcct cctacatctt
    22381 gggatggggg tcgggacgtg tgccgtactg catccggcac aacactgtct ccgcgacgtc
    22441 ccttgggctg acccccgact gcgccaacgg gaacgcgcga ccaaccccga cgccgactgg
    22501 ctgtcctagg cggaccgtac tgggcaaccg ctggcctcag tgctcttcat gagcagctgc
    22561 gagccctggg cttctcggtc acacagaccc cgcaccgccg cgttccgcta gcttcaaccc
    22621 tcaacctgag gtcccgtcgc cacgcaggag gtgtgcagga gccatggcct ggggtcagct
    22681 ggactgcttg ccgggttctt ggggggcgtg gaggtaggcg acgttcttca gcgacacgcc
    22741 gggctcaaca gcacgaccgg tggctcgctg aaaaatccgc tccaagcggt cccctcttcc
    22801 cttcgcgcac atgcagcttt accgtggggc gtcctcatca cccctgcgag ggttcgcaac
    22861 cgctctaccg gcccaataac catctcctcg tcgtgtcctc gtcacccctg cgagggttcg
    22921 caacccaccg gctactaccc gcgcggcgca cggctgccca cgtcctcagc acccctgcga
    22981 gggttcgcaa cgcgagcagc gcgcgaggca tgcggcctac ctcgtgtcct cattgcccct
    23041 gcgagggttc gtaacacggc gccgtgatcg gtggggctgt agtagtggtc gggacctcat
    23101 cgcccctgga agggtgcgcc accaaccgag acgcatggcc gtgtcatttg gcgcgaattt
    23161 cctcagcgtc ctactgggat tgttgctgtg acgtggaggg ggcattcatg cggggtggct
    23221 ggggggcggc atcgggtggg gtgaggctct ggtcaggtgc gacggggtgc ggggatcact
    23281 ggggtttgtc ggggggcggt gcctggggga tggggttgtt ggttctggtg ccccaggtcc
    23341 acatggtttg cattaccggt tcgagggctt gaccgtgggg ggtgagggtg tagcggacgc
    23401 gtgggggcca gccgggggtg cggtggcgtt cgatcacgcc tgcgttggtc agctgggtca
    23461 ggcggtcgga gaggaccttg tccgagaggg tggggagggc ggcggacagt tctgagtatg
    23521 ttgcttcgcc gcggcgcagg aactcgcgga ggacgagggg ggtccagcgg ccggccaggg
    23581 cggcgagggt gatgtctatg gggcagtggg gggcgcggtc gggcgggact agggcgctgt
    23641 cggggcagtc cgctagcggg ccgcgttcgt gtccaaccgt ttggtgagtc acgggagctc
    23701 tttctagggt tttcggtgaa cagtccgccc gcttcttatc cggaggccct cgtgcgtatt
    23761 catcatctga actgtgcttc tcttcgtaag atacccccgg tcggtggggg tggtgagctg
    23821 gccgccgtgt gtcactgctt gctcatcgag acggattcgg atgggctggt tctggtcgat
    23881 acgggccttg gtatggctga cctgcgcgat cctgaggaga ggttgggtgc ggagtgggtg
    23941 gccttcgccg agcctgggcg ggacgtggcg gtgagcgcgt tccagcaggt catcggcctc
    24001 ggctacgcgc cgcaggacgt tcggcacatc gtgctcaccc atctgcaccg cgaccatacc
    24061 ggggggctgc cggattttcc gggcgcgaag gtgcatgtgg gggatgttga gtacagggcc
    24121 gtgactgatt cggcggcccc gcaccatcgg gagagtcttg agcggttcat ggcggcgcat
    24181 cgggcgcatg gtccgttgtt gacgcctgtt tctgctgacg agcgtgagag ttggtttggt
    24241 attcaagggg tcgcgcggcc gcaggggatg gaatgcgagt tggtgctggt gccgttgccg
    24301 gggcattcgg cggggcattc gggtgtcgcc gtgcgtgacg gtgttgggcg gtggttgctg
    24361 catgcaggcg acgcttatat gtaccacggt gagatcgagg agactccgcc cttgtctcat
    24421 cccattcttg acctggttca ggacggggcg cagaccgacg tcgaggcgcg ggtgaacacc
    24481 cgggatcggc tgcgcgccct tcgccgtgac catggggatc aggtcaccgt tttcagtgcg
    24541 cacgacccct gggaattcgc ccgcatcagt gattgaccgc cgcaccgtcg gacggcttgt
    24601 gcgcaggtca gtcggtgggg agcgggatta tctgggtggg gcagcccatt gtggttttga
    24661 ttactgagcc gatctcggtt tgtgtctggg cagcctcgaa gaggtcgttg gagttcgggt
    24721 ggatggtgcc aaggagcttg ttcgccttgc ccacgctggc gctcggcttt gcgccttcgg
    24781 ctttgctgcc cgcgtcgagt tcggcggtca ggcgtgggcc ggtggtgttc aggctccggc
    24841 gtagctggtc ggtcaggcgg tcggcctcgg agacaccggt ggggccgatc tgcgcggcgg
    24901 tcttcgtcgc gatgtcgagt gcgtcgcggg acgtcccgaa gagcttgcgc agtttcgctt
    24961 cgtcggccgc gtccgggtcg atgggcgggt cgatgatgta gacgttgccg agtgagcgca
    25021 cggccaagca gaacttgatg gcccagacgt tcaggtcggt ggcggccggt ttcgctttcc
    25081 ccggcgcgga ttccgaggga gaggtcggac tcttcggtga cgccgttccg tccgaatccg
    25141 agcatccgca agtcaatgtg atgagcgcca ggcagcaggc gccgatcagg gttcgccgcg
    25201 ccatgccgtc cgcctcattg atgggttacg gctcaccacg ccgatgacac gctgaagcct
    25261 gcggagggca gggtcgacag gcttctttcg cgtcccaccg tgccgaggtc cttgcccgag
    25321 cattcctcgc ccgagtacac ggtcatgacg acatcgatgg cgcttctgtg ggtgttggcg
    25381 accgagcgga gcggaatcgg cgactcctgg catccgccgc ccgcgcggaa ggtcaccatc
    25441 tgtccctgga aaccgggttg cgaccagccg cacaacgagg cgatggggca atcaccgatc
    25501 ccgccggacg tcgtcgcgga agcgggcgac gtcggcagca cggccaccga cgccgccgcc
    25561 gacacggcca gcgagatacg gcccagcacc cgcaccgtgg aggtgctccc tctgcggatt
    25621 ctcatgccga acacagttac ggcgagcccc gcgaccgtcc ataagttgga cgaaggttgc
    25681 cgaaaccgga caccgcgccc cacctttaac gcttcagatc agagatggga tgccgaaaaa
    25741 atgccccgcc tgatgatcag cttcggcccg tccggatctc ggtaggggcc acccggtcat
    25801 gtgctctgct tgagttcgga caccagcgcc gcaaatgcgt cctggctgag gacgagcttg
    25861 gggcccccgg ggtccttgct gtcgcggaag gcgactgtct ggggaaagcg accgacctcc
    25921 acgcagtcac tgccgccctg agttccgctg tgggtgctct tacgccactt cgtcgccact
    25981 gaac
//
