LOCUS       NZ_JAICDG010000002     11149 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinomadura terrae strain OS3-83 contig2, whole genome shotgun
            sequence.
ACCESSION   NZ_JAICDG010000002
VERSION     NZ_JAICDG010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura terrae
  ORGANISM  Actinomadura terrae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 2162430)
  AUTHORS   Lee,S.D., Yang,H.L., Kim,I.S., Choe,H. and Kim,J.S.
  TITLE     Actinomadura terrae sp. nov. and Actinomadura litoris OS3-89,
            isolated from rhizosphere soil of cactus
  JOURNAL   Int J Syst Evol Microbiol 73 (1) (2023)
   PUBMED   36748505
REFERENCE   2  (bases 1 to 2162430)
  AUTHORS   Lee,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2022) Institute of Jeju Microbial Resources, BioPS
            Co., Ltd., Sancheondan Dongil 16, Jeju 63243, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 141x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022751215.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:12:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,085
            CDSs (total)                      :: 8,002
            Genes (coding)                    :: 7,936
            CDSs (with protein)               :: 7,936
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 2, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 13 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 3 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1813285
            Orig. end                         :: 1824434
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAICDG010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11149
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="9"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11149
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11149
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6149](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6149
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            998..2470
                     /locus_tag="K2F47_RS18290"
     CDS             998..2470
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="K2F47_RS18290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_242905076.1"
                     /transl_table=11
                     /translation="MTRSNPPVALAAAGTATFLTMLDATAVSIAAPRLTEDLGASLDEL
                     MWVFNAYVLVLAVTLITGGRLGDLLGARRTFLTGLAIFTVASGLVWFAAAPLALIVLRA
                     VQGLGAALLMPQAIVIVGMVYPRERLGAAFGVLSSLAGVASVLGPTVGGVLVTTLGWKW
                     IFLVNVPAGVLGAVLTLAGVPRDVPPGRRRLDLRGVLLCFSGLFLVSYGLIEGQRYDWG
                     RIGSFVSVPLVIAAGLVLLAAFGVSQRGRPHALVPPSLLRDRAFVMTNLVAGFTAFALL
                     GFYLPLTLYLQFARGMPADRAGLALAAMPLVSMVTALVAGRLVDRIGGKRVLMAGLAAF
                     TAGLAATALVAGSGTSAWALQPGLLVIGLGTGLTFPPMTTLAMRDVPHGAAGAAAGVFN
                     STRHLGNVMSAAAVGALLQNRIAAALPREGGGRWRAAIEAADLDGRSRTYTEALRPTLL
                     LSVALLAAALACAAALPPGRRERAAPELARRA"
     misc_feature    1778..1780
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2499..3149
                     /locus_tag="K2F47_RS18295"
     CDS             2499..3149
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="K2F47_RS18295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_242905078.1"
                     /transl_table=11
                     /translation="MDRREQSEKVARELTAGIEEERQRLRREVHDQMAPALAALRLRFD
                     LAREIVAVDEEGALDSVDEAIRNVGEALSGLLAAIDGAFPAELARLGLVGALAELGAFL
                     SMVDLRIDAAECDIREMSPPCEVAAYKIAAEALTNARKYSSDRSAAVTIDRQEDDIVLQ
                     VTSSIGIERESHPSYGVGFHSMRERAAALGGKCNVHASDEGMVVRARMPLRPA"
     gene            3146..3799
                     /locus_tag="K2F47_RS18300"
     CDS             3146..3799
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.5"
                     /locus_tag="K2F47_RS18300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_242905080.1"
                     /transl_table=11
                     /translation="MSVRVRVLLVEDHPLYLGALRALFEHGDDFEVVGEAGTAAAALEL
                     LPEARPHVVTLDLRLPDDAHGSLTQRVLAAAPEARVLVISALTEKASVLAALRSGVHGY
                     LTKEAGSEEIRHSVRLVAAGGTAFSEPITALLRDWLKADSGTAAKMHFPTLTDREREVL
                     DLLAAGREYAEIAGQLGISEKTIRNHLSNLFVKLQVNNRAQAILVARQAGMGTS"
     gene            3838..4443
                     /gene="hisG"
                     /locus_tag="K2F47_RS18305"
     CDS             3838..4443
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0003879 - ATP phosphoribosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000105 - L-histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisG"
                     /inference="COORDINATES: protein motif:HMM:TIGR03455.1"
                     /locus_tag="K2F47_RS18305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP phosphoribosyltransferase"
                     /protein_id="WP_242905082.1"
                     /transl_table=11
                     /translation="MLSVVLPDGAARKPALDLFAAAGLTVRRPSRRALRGKVDDPRVDQ
                     VYILPAPQIPRYLERGRFDLGITGRDRGHRTAVSVISLGELCLPGPPSDLVAPMELLAS
                     RRAHRDTVKRSAMDDLMTLLSGAVHAGRKTLLKVRVPEARLVAVTEILAALTRPTSVPL
                     LGGGEHAVEAVVDRRDISVLVPALKRAGAISIMEIPTR"
     misc_feature    complement(4727..4740)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            5001..6149
                     /locus_tag="K2F47_RS18310"
     CDS             5001..6149
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.5"
                     /locus_tag="K2F47_RS18310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_242905090.1"
                     /sec_met_domain="YcaO (E-value: 9.2e-37, bitscore: 124.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRARALIDEALDEAGLRPRLTDLHGAWRCRLSRPDGTPVRAGVG
                     VGRGDYQAAQVGALYEALERHHAAALPARGERIELLTAARLADTDLAGDPVLAPLAASG
                     GQGAVAAAVACRTYTALDHSGRTLPVPVFLTTPAYLECPPDRRHELGDVLDYAPLRGSG
                     TGGGTAIGATRDEALVHALAEAVERDAYALLLAGTFLTACPPPLRLVRPASLPAHLQEL
                     YLSAGWQVGATVALIDMTTELGIPTFCAHASRNGKAVRGQGASLSAEYAVRRALSELIQ
                     AAAIRRGEWNPPPPRRPRPPDAASAGFDPHLAAARQCDFIPTGTPAAPREHLQRLTAAL
                     TGHGHRPYGRVLHTEPNGVTTVSVFVPGLERCPAGPAAPSRT"
     misc_feature    complement(6202..6216)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.6"
                     /tool="antismash"
     gene            6376..7446
                     /locus_tag="K2F47_RS18315"
     CDS             6376..7446
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037833.5"
                     /locus_tag="K2F47_RS18315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_242905092.1"
                     /transl_table=11
                     /translation="MAVASSGYAVAASAAPGPVLVDEPFTRATADSRFVGYGAACLTGA
                     ARGDAPAEGANHPLAGCRRDPAGPVPPGGAERRGYLQLTDAHPEVTGAVMFDSPVPARD
                     GLEVTFEQWQYGNTTRAPADGISFFLTDGAGPLHTPGAFGGSLGYAQKLPGGRSGAQFV
                     PGVENGYLGIGLDTLGEYFGDGERRGNGCERRSPAGTEFRVPAPGPNIVSARGPGNGTE
                     GYCLIDATTSNKSSTGPWRSSLPGRLHGGLASMPARATPQQAESRLEPVKRTVRVVLTP
                     APDPMVTVAIDFQDGEGFQQVLRFAAPQPVPDAYRFGFAASTGPLTDVQLIRRVVLRAQ
                     RPAQGQESSEESSEDD"
     gene            complement(7505..8017)
                     /locus_tag="K2F47_RS18320"
     CDS             complement(7505..8017)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS18320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242905093.1"
                     /transl_table=11
                     /translation="MSFSPEVLPAAVNAIANSPSRQRPVVMITCGADGLPQVCVPDWGE
                     LRAVGDRHLRVSVWPTDPTAINLDRAAPVLLVVTALSDVYLVHATARRLADAAMVWAHY
                     ELTITSARIADRGTTPRLVPDHDTPTEFPAQRLPRARDMLGGKVTALRTHRRDPGHYRG
                     DLGDLRL"
     misc_feature    complement(8102..8117)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 25.17"
                     /tool="antismash"
     misc_feature    8103..8116
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.32"
                     /tool="antismash"
     misc_feature    8116..8127
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.12"
                     /tool="antismash"
     gene            complement(8270..8755)
                     /locus_tag="K2F47_RS18325"
     CDS             complement(8270..8755)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020542531.1"
                     /locus_tag="K2F47_RS18325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron chaperone"
                     /protein_id="WP_242905094.1"
                     /transl_table=11
                     /translation="MSEARKATTGDAAASEKNFDGFSDDERAAMKEHAKELKKAARRSS
                     SLAKAREEGERDVREKIAEMPDADRVLAERLHEIIASVAPDLVPRTWYGMPAYAKDGKV
                     LCFFQSAQKFKSRYATLGFSDVAALDDGTLWPTTYALTELNAANEAVVSDLVKRAVG"
     misc_feature    8785..8800
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.12"
                     /tool="antismash"
     gene            complement(8842..9297)
                     /locus_tag="K2F47_RS18330"
     CDS             complement(8842..9297)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1298: putative carboxymuconolactone decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891852.1"
                     /locus_tag="K2F47_RS18330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_242905095.1"
                     /transl_table=11
                     /translation="MQSRMQNPAAVLTGAMQPIQQLFKAAHSGGVEQQTLELVHLRASQ
                     INGCSACVDSGAKSARKAGVSEDRLAAVAAWREAPYFTDEERAALALAEAATRLADRPD
                     AVDDETWDAAATYYDEKQLAAIVLMIALTNLFNRLNATTRQIAGAWG"
ORIGIN
        1 ccgcgctccg cgacgcggac ggcggcggcc tcgccgcgga catcgacgcc tacatcgacg
       61 agtacggcta ccgcagcctg aacgagctga agctggagga gccggacctg cggcaggacc
      121 cgtccgtgct gctggagatg ctccgggtcg ggctggtcgc cgaggggcac caggcggccg
      181 ggccgtcgtc cgccgaggcc gacgcctacg tcgacgaacg gctgagcggc gcgcgcaagt
      241 tcgtctacaa gctcgtccgg ggcaaggtcc gccgctcgct ggaggccagg gagcgggtcc
      301 gcttctgccg gacgagggcg ttcgggctgg tccgccgcat gatgctggcg atcggcgcgg
      361 acctggcgcg gtcgggcatg atcggctcgg cgcgggacgt cttcctgctc aggctcgacg
      421 aggtcgccgc gtgcctcgac ggcacctact cgcacggcga cctgcgtccg ctgatcgagc
      481 tgcgcaaggc ggagctggag cggttcggcg cgctcgacgc gcccgcccgg ttcacgacga
      541 cgggcctcat ctacgaccgg cgggggctta cggcgggcgg ctgggtgcgt cccggcgcgg
      601 acgggcacga cgggcgggac ggcgcggtcg agcccggcca ccggttcgag ggcacgccgt
      661 gcagtcccgg aacggcggag ggggaggcgc gggtggtcga gcgtccgcag gacgcggccg
      721 gcggggtcat cgtcacctac cgcaccgacc ccggctggat ctcggccctg cccgccgcca
      781 aggcgctgct catcgagcgc ggcagcccgc tcacccacat cgcgatcgtg gcgcgcgagc
      841 tgggggtccc ggcgatcgtc cagatcaagg acgtcacccg gaaggtgcgc gacggcatgc
      901 ggctgcgcgt cgacggcacg accgggacgg cgacggtgac cgccgccgcc cccgcccctg
      961 ccgccgccgc tccggcggat gccgagggag gggggacatg acgcggtcga acccgccggt
     1021 cgcgctcgcg gcggccggca ccgcgacctt cctgaccatg ctggacgcga ccgccgtcag
     1081 catcgccgcg ccccggctca ccgaggacct cggcgcctcg ctggacgagc tgatgtgggt
     1141 gttcaacgcc tacgtgctcg tgctggcggt cacgctcatc accggcggcc ggctcgggga
     1201 cttgctcggc gcgcgccgga cgttcctgac cggcctcgcg atcttcaccg tcgcgtccgg
     1261 tctggtctgg ttcgccgccg cgccgctggc gctgatcgtg ctccgggccg tccagggcct
     1321 cggcgccgcg ctcctcatgc cgcaggcgat cgtcatcgtc ggcatggtct acccccggga
     1381 gcggctgggc gccgccttcg gggtgctcag ctcgctcgcc ggggtggcga gcgtgctcgg
     1441 gcccacggtc ggcggcgtgc tggtcacgac gctcggctgg aagtggatct tcctggtcaa
     1501 cgtcccggcc ggggtgctcg gggcggtgct cacgctcgcg ggcgtgccgc gcgacgtccc
     1561 gcccgggcgg cgccgcctcg acctgcgggg cgtcctgctg tgcttctccg gcctgttcct
     1621 ggtctcctac gggctgatcg aggggcagcg ctacgactgg gggaggatcg ggtcgttcgt
     1681 gagcgtcccg ctggtcatcg ccgccgggct ggtgctgctg gccgcgttcg gggtctccca
     1741 gcggggccgc ccgcacgcgc tggtgccgcc gtcgctgtta cgcgaccgcg ccttcgtcat
     1801 gacgaacctg gtggccggtt tcacggcctt cgccctgctg ggcttctacc tcccgctcac
     1861 gctctacctc cagttcgcgc gcgggatgcc cgcggaccgg gccgggctcg cgctcgccgc
     1921 catgccgctg gtctccatgg tgaccgcgct ggtggcgggc cgcctggtcg accggatcgg
     1981 cgggaagcgc gtcctgatgg cggggctggc cgccttcacc gccggactcg cggcgaccgc
     2041 cctggtcgcc ggaagcggca cctcggcgtg ggcgctccag ccggggctgc tcgtgatcgg
     2101 gctcggtacc ggcctcacgt tcccgccgat gaccacgctc gcgatgcggg acgtcccgca
     2161 cggcgcggcg ggcgcggcgg ccggcgtgtt caacagcacc cggcacctcg ggaacgtcat
     2221 gagcgccgcc gccgtggggg cgctgctcca gaaccgcatc gccgccgcgc tgccgcgcga
     2281 gggcggcggg cggtggcgcg cggcgatcga ggccgccgac ctggacggcc ggtcgcgcac
     2341 ctacaccgag gcgctgcggc ccacgttgct gctgtcggtc gcgctgctgg ccgccgcgct
     2401 ggcctgcgcg gcggcgctgc cgcccggccg gcgggagcgg gccgcgccgg aactggcgcg
     2461 gcgcgcgtga tgggaaggac cgattggggg gtggacggat ggatcggcgg gagcagagcg
     2521 agaaagtcgc gcgggagttg accgccggaa tcgaggagga gcggcagcgg ctgaggcgcg
     2581 aggtccacga ccagatggcg cccgccctcg ccgcgctgcg gctgcgcttc gacctggccc
     2641 gcgagatcgt cgccgtcgac gaggagggcg cgctcgactc ggtggacgag gcgatccgca
     2701 atgtcggcga ggctctttcg ggcctgctgg ccgccatcga cggggcgttt cccgccgagc
     2761 tggcgcggct cggcctggtc ggcgccctgg cggaactcgg cgcgttcctc tccatggtcg
     2821 atctgcgtat cgacgccgcc gagtgcgata tccgggaaat gtcgccccca tgcgaggtgg
     2881 cggcgtacaa gatagccgcc gaggcgctca ccaacgcgcg caagtactcc tccgaccgca
     2941 gcgcggccgt gacgatcgac cggcaggagg acgacattgt gctacaggtc accagcagca
     3001 tcggcatcga acgcgagtcc cacccgtcct acggtgtcgg cttccattcc atgcgggagc
     3061 gggccgccgc gctcggcggc aagtgcaacg tccacgcgtc cgacgaggga atggtcgtcc
     3121 gcgcccggat gccgttgagg ccggcatgag cgtccgcgtc cgtgtcctcc ttgtcgagga
     3181 ccatcccctc tacctcggcg cgctgcgcgc gctcttcgag cacggcgacg acttcgaggt
     3241 ggtcggcgag gcgggcacgg ccgccgccgc gctggaactg ctgcccgagg cgcggccgca
     3301 cgtcgtcacc ctcgacctgc gcctgcccga cgacgcacac gggtccctga cccagcgcgt
     3361 acttgctgcg gctcccgagg cgcgggtgct ggtcatcagc gcgctcaccg agaaggcgtc
     3421 ggtgctggcg gcgctgcggt ccggggtgca cggctacctg accaaggagg ccgggagcga
     3481 ggagatccgg cactcggtgc ggctggtcgc cgccggcggg accgccttca gcgaaccgat
     3541 cacggcgctg ctgcgggact ggctcaaggc cgattccgga accgccgcga aaatgcattt
     3601 ccccacgctc accgatcgcg aacgggaggt tctcgacctg ctcgccgcgg gccgggagta
     3661 cgcggagatc gcaggccagc tgggcatctc cgagaagacg atccgcaatc acctctccaa
     3721 cctgttcgtc aaactccagg tgaacaaccg cgcccaggcg atcctggtgg cgcgccaggc
     3781 gggaatgggc acgtcctaag gaaacgggcg cgccctaaac ttcgtggaag gcatcgcatg
     3841 ctgtctgtcg tcctgcccga cggggccgcc aggaagccgg ccctggacct gttcgcggcg
     3901 gccgggctca ccgtccgccg tccttcccgg cgtgccctgc gcggcaaggt cgacgacccg
     3961 cgcgtcgatc aggtctacat ccttcccgcg ccgcagattc cgcgctatct ggagcgggga
     4021 aggttcgacc tcggcatcac cggccgtgac cggggccacc ggacggcggt ctcggtgatc
     4081 tccctcgggg agctgtgcct gccgggcccg ccgtcggacc tcgtcgcgcc gatggagctc
     4141 ctcgcgagcc gccgggcgca ccgggacacc gtcaagcggt cggcgatgga cgacctgatg
     4201 acgctgctga gcggcgcggt gcacgcgggc cgcaaaacgc tgctcaaggt cagggtgccc
     4261 gaggcgcggc tggtcgcggt gaccgagatc ctggccgcgc tcacccggcc gacgtcggtc
     4321 ccgctgctcg gcggcgggga gcacgcggtc gaggccgtcg tcgaccggcg ggacatcagc
     4381 gtcctcgtcc ccgcgctgaa gagggcgggc gccatctcga tcatggagat ccccacccgc
     4441 tgagccggag cggcggcgtc ccggatgtgc gcgatcggtc ccgcaccatc cgaccagagg
     4501 aagcaaaatg aaacggccgt ctcatgtgtc gggggcggcc ccagtgttgc ttttcgtcgg
     4561 tgccggtcac gccggtggta acggcggcat cgtccaaact gagggattgc ggaccccaca
     4621 accgcagtgg acgcgataag cgcgaccaca gggcaagggg gaactgtccg ccgtggatgt
     4681 ttcccttcgc ggccaggtcg ggcacagtac cttccgacac tgcgagttac gcagagttag
     4741 ggagtgggtg cgatgggctg cgagtcatac cggtgtggtt cccacaccgc cgtcggcgag
     4801 ctgaccgccg aggtggcgac gcggcccggg gagcgggagc gcccgcgggc cggggaggag
     4861 tcggcccgtt gacggcgcag ggcaggtacc aacggagcgg tcccctcccg cgggaggggg
     4921 ccctctggca tcagggccgc ctccacggcg cgaacggctt cgcggccgcc gtgccccagg
     4981 ccggggaacg gtccttcccg ttgccgcgcg cccgggccct catcgacgag gcgctggacg
     5041 aggcggggct gcggccacgg ctgaccgatc tgcacggggc ctggcgctgc cgcctctcgc
     5101 gtcccgacgg cacccccgtc cgcgccggcg tcggggtggg acgcggcgac taccaggccg
     5161 cgcaggtcgg ggcgctgtac gaggcgctgg agcgccacca cgccgccgcc ctccccgcgc
     5221 gcggcgaacg gatcgaactg ctcaccgccg cccgcctcgc ggacaccgac ctggcgggcg
     5281 acccggtact ggcgccgctc gccgcgtccg gcggtcaggg ggcggtggcg gcggcggtgg
     5341 cgtgccggac ctacaccgcg ctcgaccact ccgggcggac gctcccggtg ccggtgttcc
     5401 tcaccacccc cgcctacctg gagtgccctc ccgaccggcg ccatgagctg ggcgacgtcc
     5461 tcgactacgc cccgctgcgc gggtccggca ccggcggcgg caccgcgatc ggcgccaccc
     5521 gcgacgaggc cctcgtgcac gcgctggccg aggcggtcga gcgggacgcc tacgcgctgc
     5581 tgctggccgg aacgttcctg acggcctgcc cgccgccgct gcggctggtg cgcccggcga
     5641 gcctgcccgc ccatctccag gagctctatc tgagcgccgg atggcaggtc ggggccacgg
     5701 tcgcgctgat cgacatgacc accgaactgg gcattccgac gttctgcgcc catgcctccc
     5761 gcaacgggaa ggcggtgcgg gggcaggggg cgtcgctgtc ggccgagtac gcggtgcggc
     5821 gcgcgctgag cgagctgatc caggccgccg cgatccggcg cggcgagtgg aacccgccgc
     5881 cgccccgccg cccgcgcccg ccggacgcgg cgagcgccgg cttcgacccc catctggccg
     5941 ccgcccgcca gtgcgacttc atcccgaccg gcacgcccgc cgcgccccgc gaacacctcc
     6001 agcgcctgac ggccgcgctg accggccacg ggcaccgccc ctacggccgg gtcctgcaca
     6061 ccgagcccaa cggcgtgacc acggtgtcgg tgttcgtgcc cgggctggaa cgctgccccg
     6121 ccggccccgc ggcgccttct cgaacgtgac cttcatgggg ggccgcgcgg gcgagccgtg
     6181 accgccgcat gggccgacat gcgtttcctt aatattctgc cgcgcatatt cccatgggat
     6241 cggtaatggc ctgctcccgc gccgagttcg tggtcggatg agtccggtga aggggaccag
     6301 ccgagaactc gcgcaggaag aatcgacgat atgagacatg ggttgactcg cgtggtcgcg
     6361 tcggtcggtg ccgttatggc cgtcgcgtcg tccgggtacg cggtggcggc gtccgcggcc
     6421 ccgggaccgg ttctggtgga cgagccgttc acccgcgcca ccgccgactc gcgcttcgtc
     6481 ggctacgggg ccgcctgcct gaccggcgcc gcgcggggcg acgcgccggc ggagggcgcg
     6541 aaccacccgc tcgcgggctg ccgccgggac ccggccggtc cggtgccccc gggcggggcg
     6601 gagcggcgcg gatacctcca gctcaccgac gcccaccccg aggtgaccgg cgccgtgatg
     6661 ttcgactcgc cggtccccgc gcgggacggg ctggaggtga ccttcgagca gtggcagtac
     6721 ggcaacacca cccgggcgcc cgccgacggg atctcgttct tcctcaccga cggcgcgggg
     6781 ccgctgcaca ctccgggcgc gttcggcgga agtctcggat atgcgcagaa actgccgggc
     6841 ggacgatcgg gcgcgcagtt cgtccccggc gtcgaaaacg gatatctcgg catcgggctc
     6901 gacacgctgg gggagtactt cggcgacggg gaaaggcgcg ggaacggctg cgagcggcgc
     6961 tccccggccg ggacggagtt ccgcgtgccc gcccccggcc ccaacatcgt gtccgcgcgc
     7021 ggccccggaa acggcaccga gggctattgc ctgatcgacg ccacgacgag caacaagtcg
     7081 agtacgggcc cctggaggtc gagcctcccc ggacggctcc acggcggcct cgcgtcgatg
     7141 cccgccaggg ccacgccgca gcaggccgag agccggctgg agccggtcaa gcggaccgtc
     7201 cgcgtcgtgc tgacgcccgc gccggacccg atggtcacgg tcgccatcga cttccaggac
     7261 ggcgagggct tccagcaagt cctgcggttc gcggcgccgc agcccgtccc ggacgcctac
     7321 cgtttcgggt tcgccgcgtc caccgggccg ctcaccgatg tgcagctcat ccggcgggtc
     7381 gtcctgcgcg cgcagcgtcc ggcccaaggc caggagtcgt ccgaggagtc gtccgaggac
     7441 gactagcgcg aaagcccggc cgcgaacccg cggccgggcc tcgttccggt cgtgcggcct
     7501 ccggtcagag ccggagatcg cccaggtcac cgcggtagtg gccggggtcg cggcgatggg
     7561 tgcggagcgc cgtgaccttc ccgccgagca tgtcgcgggc ccgcggcagg cgctgcgccg
     7621 ggaactcggt cggggtgtcg tggtcgggga cgaggcgcgg ggtggtgccc cggtcggcga
     7681 tccgcgccga ggtgatcgtg agttcgtagt gggcccacac catggccgcg tcggcgagcc
     7741 ggcgggccgt ggcgtggacg aggtagacgt cggacagggc ggtgacgacc agcagcacgg
     7801 gcgcggcacg gtccaggttg atcgcggtgg ggtcggtcgg ccagaccgac acccgcaggt
     7861 gccggtcgcc cacggcgcgc agctcgcccc agtccgggac gcagacctgc ggcagcccgt
     7921 cggcaccaca ggtgatcatg acgacgggac gttgccggga cggggagttg gcgatcgcgt
     7981 tgacggcggc agggagcacc tcgggtgaga acgacatcgg tgtgtccgcc cttacgtcga
     8041 aggtccgccg gcccggcgtg cgggccgagc gggtcttggc actaatcctt cccgatatct
     8101 atcgatcata cattcgatag cgttaacgat cacacagctt tttccgagta gcgggagacg
     8161 ggggacacac gtttaccctg gggccgcaga gcccaaaccg cagccgggcc caccaccggg
     8221 gccgctgtga aacggcgccg atggtgggcc cggctgttcg attgaggggt cagcccaccg
     8281 cgcgcttcac caggtcgctg accacggcct cgttcgcggc gttcagctcc gtcaacgcgt
     8341 aggtggtcgg ccacagcgtg ccgtcgtcga gggcggccac gtcgctgaag ccgagcgtcg
     8401 cgtaccgcga cttgaacttc tgcgcgctct ggaagaagca gagcaccttg ccgtccttgg
     8461 cgtaggcggg catcccgtac caggtcctcg gcacgaggtc cggcgcgacc gaggcgatga
     8521 tctcgtgcag ccgctcggcg aggacccggt ccgcgtccgg catctcggcg atcttctcgc
     8581 ggacgtcgcg ctccccctcc tccctcgcct tggccaggga cgagctgcgg cgcgcggcct
     8641 tcttcagctc cttggcgtgc tccttcatcg cggcccgctc gtcgtcggag aacccgtcga
     8701 agttcttctc ggacgcggcg gcgtcgcccg tggtggcctt gcgtgcctcg ctcatatgga
     8761 aatctccctc tctggcgtgt ctcgtcgaac ggctcgtcga acggcgggcc ctcggcggag
     8821 ggccgcccct caaggtccgg tctatcccca ggccccggcg atctgccggg tggtggcgtt
     8881 gagccggttg aacaggttgg tgagcgcgat catcaggacg atcgcggcga gctgcttctc
     8941 gtcgtagtag gtggcggcgg cgtcccaggt ctcgtcgtcc accgcgtccg gacggtcggc
     9001 cagccgcgtc gcggcctcgg ccagggccag cgccgcccgc tcctcgtcgg tgaagtaggg
     9061 cgcctcgcgc caggcggcga ccgcggccag ccggtcctcg ctcacgcccg ccttgcgcgc
     9121 cgacttggcg ccgctgtcga cgcaggcgct gcacccgttg atctggctgg cccgcaggtg
     9181 caccagctcc agcgtctgct gctccacccc gccggagtgc gcggccttga acagctgctg
     9241 gatgggctgc atcgcaccgg tcaggacggc ggcggggttc tgcatccggg actgcatcgc
     9301 gggtttctcc ttcgtgatcg gctgccccat tccctcgggg catggctcca tcacagcggg
     9361 acgggccgcc cctgccgatg cccgtgggac accctgggac agtcgaaaca cctctgaaca
     9421 gggctaatct atctagaaga gttgtagcgg gacgggacag ggaggccggg gcggatggct
     9481 gtggaacacc ggatgccgca gaccggcccg cgcgacgacc cccgggacga gctggccgcc
     9541 cggctgcgcc tgctccagga ggtgtccgag cgcggcgtcc gtgcgctcgc gcgcgacgcc
     9601 ggcctcagct cgtcgtcgct gtcgcgctac ctgagcggcc agaccgtgcc gccctggccc
     9661 gcggtgatcg cgctgtgccg cctcgtccag cgcgatccgc gcccgctgcg gccgctgtgg
     9721 gagcgcgcgg cgaacccgct gcccgcgccg ccgaagacga gccgccaggt ccagccgccg
     9781 tcgccgcccg cgggcgcgcc gcgtccgccc cgcaacgacc tgccgcgcga cgtgcccgac
     9841 ttcaccgggc gcgaggccga gctggccgcc gtcctcgccg ccgtggacgc gagccgggtg
     9901 gtcgcgctcg acggcatggc gggcgtcggc aagacctgcc tcgcggtgca cgccgcgcac
     9961 cggctcgcct ccgactaccc cgacgcccag ctctacatcg acctgcacgg cttcaccgcc
    10021 ggacgcgagc cgctcgaccc cgatcccgcg ctgcggacgc tgctcgccgc cctcgacgtc
    10081 ccgtccgaga agatcccgca ggagggcggc atcgagccgc tggccgcgtg ctggcgctcc
    10141 gagctggcgc accggcgggc cgtcgtggtg ctcgacaacg cctccgacgc cgagcaggtc
    10201 cggctgctgc tccccggcgc cggaccgtcc gtcgccctgg tgaccagccg caaccgcctg
    10261 ctggggctgg acgaggtgcc cccggtttcg ctggacgtgc tgtccccgaa ggagagcgcc
    10321 gagctgctgg cccgcgccag cggcgacccg ggcgggtccg gcgggcggct ggcccgcgat
    10381 cccgaggcgg ccgccgaggt gctgcggctg tgcgggcacc tgccgctcgc gctgcggctg
    10441 gccgccgcgc ggctccggca ccggcccggc tggacggtcg gcgtcctcgt cgagcggctg
    10501 gcggagggcg cgagcgagtt cgacacggcg ttcgcgatgt cggtccggca gctcgaccgg
    10561 acgcggcgcc gcttcttccg gctgctcggg ctggtgcccg gctcgtcctt cgacgagtac
    10621 gtcgcggcgg cgctcgcggc cgtgccggtg cgcgatgccc gcgagatgct ggaggacctg
    10681 ctggacgcgc acctcgtcca gcagccggcg gccggccgct accggctgca cgacctggtg
    10741 cgccagcacg cgcgccgcgc cgccgacgag caggacggac cggcggagac cgaacgcgcg
    10801 atccaccgcg tcctggacta ctacgtgcac gcggcggcgg cagccgacgc cgtgatgtcg
    10861 cacgcgctgc ccggccgtgc ggtctccgtg agccacccac cagccgacct gccccgattc
    10921 gccggcaagc acgcggcgct gttctggttc ggcaccgagt acacgaacct gatggccgtc
    10981 ttcgagacgg cggtcgccgc cggggccgac cggcacgtct gcgagctgcc gcgcgccatg
    11041 cgcgcgttct tcgcgcggcg ctgcggcacc acgcacctca acgtcctgtt cgagcgctcg
    11101 ctggtcgccg cgcggcgcct cggcgaccct cagatgctgg ccgacgcgc
//
