LOCUS       NZ_JAICDG010000002     25272 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinomadura terrae strain OS3-83 contig2, whole genome shotgun
            sequence.
ACCESSION   NZ_JAICDG010000002
VERSION     NZ_JAICDG010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura terrae
  ORGANISM  Actinomadura terrae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 2162430)
  AUTHORS   Lee,S.D., Yang,H.L., Kim,I.S., Choe,H. and Kim,J.S.
  TITLE     Actinomadura terrae sp. nov. and Actinomadura litoris OS3-89,
            isolated from rhizosphere soil of cactus
  JOURNAL   Int J Syst Evol Microbiol 73 (1) (2023)
   PUBMED   36748505
REFERENCE   2  (bases 1 to 2162430)
  AUTHORS   Lee,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2022) Institute of Jeju Microbial Resources, BioPS
            Co., Ltd., Sancheondan Dongil 16, Jeju 63243, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 141x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022751215.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:12:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,085
            CDSs (total)                      :: 8,002
            Genes (coding)                    :: 7,936
            CDSs (with protein)               :: 7,936
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 2, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 13 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 3 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1507475
            Orig. end                         :: 1532747
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAICDG010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25272
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="7"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25272
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25272
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15272](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15272)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            631..1752
                     /gene="wecB"
                     /locus_tag="K2F47_RS16930"
     CDS             631..1752
                     /EC_number="5.1.3.14"
                     /GO_function="GO:0008761 - UDP-N-acetylglucosamine
                     2-epimerase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="wecB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Epimerase_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653481.1"
                     /locus_tag="K2F47_RS16930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-hydrolyzing UDP-N-acetylglucosamine
                     2-epimerase"
                     /protein_id="WP_242904293.1"
                     /sec_met_domain="Epimerase_2 (E-value: 5.7e-94, bitscore:
                     311.8, seeds: 187, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSISIAHVVGARPNLVKAAPVVAALGDLDQSVLHTGQHYDERLSK
                     VFFDELGLPEPDVNLGVGSGGHAEQTAAVMVGLEREFVRRAPDLVVVYGDVNSTIAAAL
                     VAAKLRVPVAHVEAGLRSFDMTMPEEVNRRLTDQLSDLCLVTSPEAIGHLAAEGIPVDR
                     AHLVGNPMIDTLLANLGKFDTGKVRAAHGLPERYVLATMHRPANVDAPETAAALVRHLH
                     SVADLADVVIPVHPRGRANLIAAGLDDHPRVHVLEPLGYIDFIAAVRGAAAVVTDSGGL
                     QEETTMLRVPCLTVRPNTERPITITHGTNRLVTFEELVPAAGKALSAPERHHLSLVGGR
                     PPTPPGTDRMPPLWDGHAGERIAGVIRDWTGAA"
     gene            1752..3011
                     /locus_tag="K2F47_RS16935"
     CDS             1752..3011
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152: nucleotide sugar dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653482.1"
                     /locus_tag="K2F47_RS16935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotide sugar dehydrogenase"
                     /protein_id="WP_242904300.1"
                     /transl_table=11
                     /translation="MDLVVIGLGYVGLPLVRAACRAGLRTGGLDLDARVVDGLRAGRSH
                     VDDVAPAEVAEMLGQGFEPSADERVLDGARTVVICVPTPLSTEGGPDLTAVRGAAETVA
                     RHLEPGMLVVLESTTYPGTTDEVVRPILEKSGLIAGEEFHLAFSPERIDPGNPVYGIRN
                     TPKIVGGFSPACASAAAAFYGKFVDQVVEAKGTREAEMAKLLENTYRHVNIALVNEMAV
                     FCDELGIDLWDAIDCAATKPFGFQAFRPGPGVGGHCIPIDPNYLSYKVRSLGYPFRFVE
                     LAQEINDRMPRYVVERAQQLLNREGRALKGAKVLLLGVTYKADIADQRESPARPVARRL
                     ARLGADLSFHDPHVASWRVDGADVPRAADLPAALEGADLTIVLTGHRGYDGTTLARHAR
                     LLFDAVGHTRGDPGPATELL"
     gene            complement(3025..4452)
                     /locus_tag="K2F47_RS40740"
     CDS             complement(3025..4452)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="K2F47_RS40740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_308198420.1"
                     /transl_table=11
                     /translation="MSLRRRLILSSVALAALGLLLAGLATFAAVRDWTSGRDERMLTSP
                     GRRAEAVIGSREALRTAAVPDDVTALWRVLAAEGAIPSLFQIRAADGRVLQSVTYGPVP
                     ELPGDLAPARATDGNPDGERFRTVGGDSGFRVRVAWLPGPAGAAPHTRFLVIGVQNAES
                     EELEGRTAGSMTVFGLLALLGVALVAGLAVKRGLRPLEQFGATAAAIGAGDLTRRVERA
                     DRRTEVGRLGRALNGMLAQIEAAFRERRAAEDRLRRFVADASHELRTPVATIRGYAELF
                     RRGAAGRPEDLAKAMARIESEAERMGVLVDELLLLARLDQGRALEHGPVDLGALAGDAV
                     ADARAVAPEHPVALEGEGPLAVRGDADRLRQVLANLLANVRHHTPEGTPAVVRYGVRDG
                     GAVLEVEDAGPGLTAEQRARAFERFYRADPSRSHGRGGSGLGLSIVAAVVAAHGGEVAL
                     EAAPGGGTVVRIRLPLV"
     gene            4605..6740
                     /locus_tag="K2F47_RS16945"
     CDS             4605..6740
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015155.5"
                     /locus_tag="K2F47_RS16945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MMPL family transporter"
                     /protein_id="WP_242904314.1"
                     /transl_table=11
                     /translation="MLRHKLFVAVVWLAATAAGAFAVTQVGDRLVEDFAPAGSAARDAN
                     RAIDATYRSGGESAPTVPVIVLPEGRTVDDPAVRSALGAAFQNAAKRLDARVVSYADTG
                     DRRFVGADGRTTFGLVYPRHPAGEPVDEAPDLSKPLAQIIEPSLPAGSTLRVTGMDLLA
                     DGAGEEGVSVLTETLVGGVGALLVLAFVFGSFLALVPLLIAVVSILGSFLAVYGLTELG
                     EVNFLVQFVVALIGLGVAVDYSLLLVTRWREERARGQGGEEAVHRAMATAGRSVVFSGV
                     AVSIGLIVMLVLPVPFLRSIAYGGVIIPSVSVLATLTLLPIILATAGSRLDWPRLRKDS
                     HASRAWAAWTRGVVRFRFPAALGAIAVLVALALGGLNIHLGEAGSSAGARSGPAHDGLV
                     ALRSAGIGSGVLTPVDVLVPPGGTPASAASRLADVAGVRTAVAPSGEAWRQGGSALLSV
                     IPVDEGGTNAGHDTVRRIREAVPPGAHVGGEAASDIDFVDQVYGVFPWLLGLIALLTFV
                     LLARAFRSLVLPLKAVALNLLSLAAALGSVTLIWQEGHGSDAVWGVPATGAIGAFIPCL
                     IFAFLYGLSMDYEVFILARIREEYERTGSTEEAIVEGLGRTGRLVTSAALILCLAFASM
                     AAAPMTEVKVFATGLGLGILLDATIVRGVLVPALIAMFGDWNWWLPGWAARLLRVAPSG
                     PASIGAAGQPSFGSRST"
     gene            complement(6710..7408)
                     /locus_tag="K2F47_RS16950"
     CDS             complement(6710..7408)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012850957.1"
                     /locus_tag="K2F47_RS16950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_242904316.1"
                     /transl_table=11
                     /translation="MNQPAERVLVVDDEPYLADLVATALRYEGYTAETAGTCAETAARV
                     TGFRPDLIVLDVMLPDGSGLDLCHRLRREGRAAPVVFLTARDATEDKIAGLTAGGDDYV
                     TKPFSLEELIARVRTVLRRTSGARPAEARLAFADLVIDEDAYEVRRGDAPLDLTPTEFR
                     LLRYLVVNAGRVLSKRQILDHVWNHDHGGSDGVVQTYVSYLRRKVDAVEPPLIHTIPRV
                     GYVLRLPKDG"
     gene            complement(7525..8154)
                     /locus_tag="K2F47_RS16955"
     CDS             complement(7525..8154)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012309.5"
                     /locus_tag="K2F47_RS16955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="superoxide dismutase family protein"
                     /protein_id="WP_242904318.1"
                     /transl_table=11
                     /translation="MKKILSVAHLTVLATVGGLAGTVAVSAAVNAATDGGHRALTAQIR
                     DVKGNVVGALTVADQGPTHEKLTVRAWNLPPGFHGFHVHTTGKCDPEAVDPNTGKVSPF
                     FTAGGHLNLDPAHTHPSHSGDLPTLLIDESGKGSGETVTDRFQAKHLLDADGSAIIIHA
                     LPDNHANIPDRYATADGKKGPDTASLATGDAGGRFACGVIGQARRN"
     misc_feature    complement(8311..8324)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.6"
                     /tool="antismash"
     misc_feature    complement(8322..8336)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.04"
                     /tool="antismash"
     misc_feature    complement(8324..8341)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.28"
                     /tool="antismash"
     gene            8386..8907
                     /locus_tag="K2F47_RS16960"
     CDS             8386..8907
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633342.1"
                     /locus_tag="K2F47_RS16960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DoxX family membrane protein"
                     /protein_id="WP_242904320.1"
                     /transl_table=11
                     /translation="MSVRTHPTSHAPRTASHSRPYVLAVGRLFLAWIFLWAFLDKTFGF
                     GKPTKSGWLDGTSPSKGFLSHTEGPFKGMFHSMAGQTWVDAAFVFGLGGLGIALTLGIC
                     LRIAAAGGTLLLLNLWAASLWPEANPFMDEHWIYAALLIAAAAANAGDVLGLGGPWSRT
                     ALVRRYPFLR"
     gene            complement(9042..10004)
                     /locus_tag="K2F47_RS16965"
     CDS             complement(9042..10004)
                     /EC_number="1.13.12.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015047.5"
                     /locus_tag="K2F47_RS16965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitronate monooxygenase family protein"
                     /protein_id="WP_242904322.1"
                     /transl_table=11
                     /translation="MRIDTPLTRLLGTELPIVQAGMSWASSGSALPLAVSRAGGLGVIA
                     AGPMRLPDLERAIDEVEAGTDRPYAVNLPLYRKGVEEVIDLLCERRVPVLIASQGGPKR
                     YLPRFKDLGTTCLHVVAGEEHAAKAVGAGVDGLVVVGAEAGGHPPAALVSTLVMVRSVV
                     KSAPGVPIVASGGFADGAGLAAALSLGADGAQFGTRFLASVESNLHPAYKEAVLAAGVG
                     DTRTVGHQIGMIRLLANEFADRMGELERTGAELDLRRAVFAASTLRMAAFEGDVARGKV
                     EAGQSAGLVTEILPAAEIVGELVAEYAATLDRLPPVDPS"
     gene            complement(10001..11605)
                     /locus_tag="K2F47_RS16970"
     CDS             complement(10001..11605)
                     /NRPS_PKS="Domain: AMP-binding (16-430). E-value: 1.9e-91.
                     Score: 298.6. Matches aSDomain:
                     nrpspksdomains_K2F47_RS16970_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076853.1"
                     /locus_tag="K2F47_RS16970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_242904324.1"
                     /sec_met_domain="AMP-binding (E-value: 3.1e-103, bitscore:
                     342.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLEAICPLTADAALRRAAAVGADVQAIVSAQGTITYAELDAEVT
                     AVRAALAAAGVGRGDHVAVCLGNGPRWVSLFVAIGSLGAVTVPVNTRLRADEIAYVLRQ
                     SRAKLLFTADRFLSSEFCAMLRQICPGIDKALPDPALPDLKDVVVLGADVPSAARSWEE
                     FLAVDAPPVEPCSAPGDVLLIQYTSGTTSYPKGVLLTHRNMCADAFFSGARLGLRAGDR
                     FHSARPFFHAAGSTLSVLACLQHVTTLVTMDRFEAGEALRLMEAERCTHFSGNDTIALM
                     LLDHPDRPGRKLSLRGAWAAASPGIVRRIIDELGATECVVGYGLSEASPNVAQSAWWEP
                     EDVRASGRMLPEPGVEVRLRDPETGREVPTGEVGEILVRGWNVMQGYFEMPDETAAALS
                     PGGWLSTGDLGRLGPDGRLEFVGRAKDLIRVGGENVSPTEVEDCLHRHPKIKQAAVVGV
                     PDARLIEVPFAFVVLTEGREAEPEEILGWARERLAGFKAPRHLRVVAGFEEFGMTASSK
                     VQKRHLAEHARRLLEDG"
     CDS_motif       complement(10160..10201)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K2F47_RS16970_0004"
                     /evalue="1.60E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="K2F47_RS16970"
                     /protein_end="482"
                     /protein_start="468"
                     /score="-0.6"
                     /tool="antismash"
                     /translation="AFVVLTEGREAEPE"
     CDS_motif       complement(10283..10348)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K2F47_RS16970_0003"
                     /evalue="3.10E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="K2F47_RS16970"
                     /protein_end="441"
                     /protein_start="419"
                     /score="13.5"
                     /tool="antismash"
                     /translation="FVGRAKDLIRVGGENVSPTEVE"
     aSDomain        complement(10316..11557)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K2F47_RS16970_AMP-binding.1"
                     /evalue="1.90E-91"
                     /label="K2F47_RS16970_AMP-binding.1"
                     /locus_tag="K2F47_RS16970"
                     /protein_end="430"
                     /protein_start="16"
                     /score="298.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RAAAVGADVQAIVSAQGTITYAELDAEVTAVRAALAAAGVGRGDH
                     VAVCLGNGPRWVSLFVAIGSLGAVTVPVNTRLRADEIAYVLRQSRAKLLFTADRFLSSE
                     FCAMLRQICPGIDKALPDPALPDLKDVVVLGADVPSAARSWEEFLAVDAPPVEPCSAPG
                     DVLLIQYTSGTTSYPKGVLLTHRNMCADAFFSGARLGLRAGDRFHSARPFFHAAGSTLS
                     VLACLQHVTTLVTMDRFEAGEALRLMEAERCTHFSGNDTIALMLLDHPDRPGRKLSLRG
                     AWAAASPGIVRRIIDELGATECVVGYGLSEASPNVAQSAWWEPEDVRASGRMLPEPGVE
                     VRLRDPETGREVPTGEVGEILVRGWNVMQGYFEMPDETAAALSPGGWLSTGDLGRLGPD
                     GRLEFVGRAKDLIRV"
     CDS_motif       complement(10415..10501)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K2F47_RS16970_0002"
                     /evalue="1.00E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="K2F47_RS16970"
                     /protein_end="397"
                     /protein_start="368"
                     /score="24.3"
                     /tool="antismash"
                     /translation="PTGEVGEILVRGWNVMQGYFEMPDETAAA"
     CDS_motif       complement(11003..11056)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K2F47_RS16970_0001"
                     /evalue="6.00E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="K2F47_RS16970"
                     /protein_end="201"
                     /protein_start="183"
                     /score="18.9"
                     /tool="antismash"
                     /translation="IQYTSGTTSYPKGVLLTH"
     gene            complement(11602..12405)
                     /locus_tag="K2F47_RS16975"
     CDS             complement(11602..12405)
                     /NRPS_PKS="Domain: ECH (11-250). E-value: 7.4e-55. Score:
                     177.8. Matches aSDomain:
                     nrpspksdomains_K2F47_RS16975_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076854.1"
                     /locus_tag="K2F47_RS16975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_242904326.1"
                     /transl_table=11
                     /translation="MAVESDDDPVLVRREDGVAHAVLNRPAARNALNLPMCHRLRETFA
                     ELDADPGVRAVLLRANGPAFCAGADLRERKGRDEAWVRSRRLASFAAYEAIERCSKPVV
                     ALVQGPVVGSGGEIAMSCDFVVASDDATFRFPEPHWGTVGATQRLQRVIGKRRAKELLF
                     TSRTMGAEEAAAVGLVARLVPAAELAEAGERLARTIADAPPLAIALTKQAIDLGAETDL
                     ANGIRIEMAAIERCLADGAWRNGVSAFEGSIRPASGEQTVKEEGR"
     aSDomain        complement(11656..12372)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K2F47_RS16975_ECH.1"
                     /evalue="7.40E-55"
                     /label="K2F47_RS16975_ECH.1"
                     /locus_tag="K2F47_RS16975"
                     /protein_end="250"
                     /protein_start="11"
                     /score="177.8"
                     /tool="antismash"
                     /translation="VRREDGVAHAVLNRPAARNALNLPMCHRLRETFAELDADPGVRAV
                     LLRANGPAFCAGADLRERKGRDEAWVRSRRLASFAAYEAIERCSKPVVALVQGPVVGSG
                     GEIAMSCDFVVASDDATFRFPEPHWGTVGATQRLQRVIGKRRAKELLFTSRTMGAEEAA
                     AVGLVARLVPAAELAEAGERLARTIADAPPLAIALTKQAIDLGAETDLANGIRIEMAAI
                     ERCLADGAWRNGVSAFE"
     gene            complement(12408..13595)
                     /locus_tag="K2F47_RS16980"
     CDS             complement(12408..13595)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076855.1"
                     /locus_tag="K2F47_RS16980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CaiB/BaiF CoA-transferase family protein"
                     /protein_id="WP_242904328.1"
                     /transl_table=11
                     /translation="MRPLDGIRVLDFSRVLAGPMATQILADLGAEVIKVERPGGGDESR
                     LFEPKLPGGESAYFFAFNRGKRSITLDLSTPRGQEIARGLARQADVLVENFLPGAMERR
                     GLGYEALAKENPRLVYVSGTGFGQSGPYSDRKGYDTIFQALSGVMALTGHPGTPPAKAG
                     VPIADLTSGLWIVIAALAGLAGRDASGRGGHADLAMMDVQVSLLAVAAARLFALDEDPV
                     RTGTGHPGRVPSAAFECADGRWLHISGSDHHWRPLCKVLGLDELAADPDLATNAGRVAR
                     RAHVTAALTEAFAGWQRDELAAALRAAGVPAGEVNSVREALADPHTVERGMVRHFEHPV
                     EGRFPALRTPLRIDGYDDPEPAAPPLLGSDTAAVLGELLGLGEAEISRLRDEGTI"
     gene            complement(13592..14335)
                     /locus_tag="K2F47_RS16985"
     CDS             complement(13592..14335)
                     /NRPS_PKS="Domain: ECH (12-228). E-value: 3.1e-48. Score:
                     156.2. Matches aSDomain:
                     nrpspksdomains_K2F47_RS16985_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076856.1"
                     /locus_tag="K2F47_RS16985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_242904330.1"
                     /transl_table=11
                     /translation="MLTRDTSTDVLVTEDHGAVRVLRLNRPAKLNALNTELTAALLAAL
                     RAADADGAVRAVVLTGTGRAFCAGADLTEFKDLTPDDQTAVVRRAELTMRSQMLPQQLT
                     KPVISAVRGHAMGGGAGLAIGCDMMVAASDTKLGYPELRHSLVPAVVMTGLQRHFGRKF
                     AFELISTGRILSAAELAERGIANRVVEPGAEVEAALEIAAGWAEVNADAMIAAKALFYR
                     VADLPFEEAMRTGADVNAIMRGFRP"
     aSDomain        complement(13652..14299)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K2F47_RS16985_ECH.1"
                     /evalue="3.10E-48"
                     /label="K2F47_RS16985_ECH.1"
                     /locus_tag="K2F47_RS16985"
                     /protein_end="228"
                     /protein_start="12"
                     /score="156.2"
                     /tool="antismash"
                     /translation="TEDHGAVRVLRLNRPAKLNALNTELTAALLAALRAADADGAVRAV
                     VLTGTGRAFCAGADLTEFKDLTPDDQTAVVRRAELTMRSQMLPQQLTKPVISAVRGHAM
                     GGGAGLAIGCDMMVAASDTKLGYPELRHSLVPAVVMTGLQRHFGRKFAFELISTGRILS
                     AAELAERGIANRVVEPGAEVEAALEIAAGWAEVNADAMIAAKALFYRVADLPF"
     gene            complement(14322..15272)
                     /locus_tag="K2F47_RS16990"
     CDS             complement(14322..15272)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076858.1"
                     /locus_tag="K2F47_RS16990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_242904331.1"
                     /sec_met_domain="HMGL-like (E-value: 2.4e-39, bitscore:
                     132.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDGVTICECFARDGLQHEETHVPADVKIALIGAFADAGFRRAEA
                     TSYSHPGRVPAFSDASEVLAGLPRPAGVSYKATCPNPRAVERALADLDAGHGADELSLL
                     VSATESHTERNMRTTREKQWERITEMVRLAGGRFKLVGVVSVAFGCPFEGQVDPGVVAD
                     DAARFADLGVDMVTLGDTTGLATPSAVKSLFKRVSSARPDIPVVAHFHNTRGSGIANCV
                     AALEAGCRDFDSSLGGVGGHPTRIQYGQGMTGNVCTEDLVNLLESEGVDTGLDLDKVMA
                     ASRMCEEALGRSLYSMVARAGFGPACRKEFQDAHA"
     misc_feature    complement(15246..15260)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.52"
                     /tool="antismash"
     gene            complement(15394..15885)
                     /locus_tag="K2F47_RS16995"
     CDS             complement(15394..15885)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024212.5"
                     /locus_tag="K2F47_RS16995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_242904339.1"
                     /transl_table=11
                     /translation="MNADPARSADPAAETTALLPIRELLSYRLHRVANALSRSAALRYR
                     REYGVSLHEWRTVALLGADEPQTVNQLARLAGLDKAQMSRVVTKLTERGLLERQPGPGR
                     STQLSLTRSGKSLYRGLISAANDRNEAFLACLTPDEQEVLDSALRKLAAVGRALERAEH
                     "
     gene            16025..17482
                     /locus_tag="K2F47_RS17000"
     CDS             16025..17482
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077036.1"
                     /locus_tag="K2F47_RS17000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_242904341.1"
                     /sec_met_domain="Aldedh (E-value: 4.7e-150, bitscore:
                     497.0, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAEPSTATLLIDGEWRPGPTAFEVVDPATLEVVAHAADAGPGEA
                     LAALEAACAAFPAWRATPSEDRATALRAAAAAIRAAAEPLAELMTSENGKPLHEARGEV
                     MGSARMLDWAAEEGRRADGRVTPGNQAGPGLVLRTPVGPALAITPWNFPASMLVRKVGL
                     ALAAGCPVIVKPAEQTPMIGTELVRIINEAAALPAGVLQSITTTRPAEVVGALLDDPRL
                     RKVSFTGSTEVGLGLIRSTGARLRRTSLEMGGHSPAIVFGDADLATAAAAVSAAKFANA
                     GQSCIAINRLYVQRGALEEFLPLLLERVAALRLGHGADEGTTLGPLIDFAGLDKVERHV
                     TDAVKRGATVAAGGRRWTGEGARPGLTGAFYEPTVLTGVDDSMLISSEETFGPVLPIYA
                     FDDDEDALRRANASEYGLAAYVFGSGLSRIWRAVESLDFGIVAVNDPAPVRPELPFGGM
                     KNSGQEREGGSEGIDAYLETKSVSVRL"
     gene            17493..18800
                     /locus_tag="K2F47_RS17005"
     CDS             17493..18800
                     /NRPS_PKS="Domain: Aminotran_3 (40-382). E-value: 1.2e-95.
                     Score: 312.3. Matches aSDomain:
                     nrpspksdomains_K2F47_RS17005_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077039.1"
                     /locus_tag="K2F47_RS17005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_242904343.1"
                     /sec_met_domain="Aminotran_3 (E-value: 5.7e-95, bitscore:
                     315.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMEQHATREQADATDLAERDVRTIIHPHSVIGEPAEPLVLDRGE
                     GAVVWDVQGRSYIDGTCGLWQCPVGHGRRELADAAAAQIAKLEFYSSFGDYSNEPSIRL
                     AEKLLELAPAGLRRVFFTNGGSEGNETAIKLARLAQHHAGHPERTIVLARSAGYHGMGG
                     GSLAATGIDRLREGYGPLVPGIEFLGKPHAVAGDPGTADRLIAELEERIESIGPERIAA
                     FIGEPVLGVGGMVPPPDGYWPRVQEVLRRHGILLIVDEIVTAFGRTGHWFASERYGIEP
                     DMIVTAKGLSSGYIPMGAVLIGQRVLDLAGGAAFLHGFTYNGHPVGAAVALANIEILRR
                     ENLLERATTLGTRLLDALRPLEELDHVLEVRGVGLMLGIEFTGGDTSGVQAGARAEGVI
                     VRASGTSIVLSPPLVITEEQVDTLARVLIEQVRAAH"
     aSDomain        17613..18638
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K2F47_RS17005_Aminotran_3.1"
                     /evalue="1.20E-95"
                     /label="K2F47_RS17005_Aminotran_3.1"
                     /locus_tag="K2F47_RS17005"
                     /protein_end="382"
                     /protein_start="40"
                     /score="312.3"
                     /tool="antismash"
                     /translation="LDRGEGAVVWDVQGRSYIDGTCGLWQCPVGHGRRELADAAAAQIA
                     KLEFYSSFGDYSNEPSIRLAEKLLELAPAGLRRVFFTNGGSEGNETAIKLARLAQHHAG
                     HPERTIVLARSAGYHGMGGGSLAATGIDRLREGYGPLVPGIEFLGKPHAVAGDPGTADR
                     LIAELEERIESIGPERIAAFIGEPVLGVGGMVPPPDGYWPRVQEVLRRHGILLIVDEIV
                     TAFGRTGHWFASERYGIEPDMIVTAKGLSSGYIPMGAVLIGQRVLDLAGGAAFLHGFTY
                     NGHPVGAAVALANIEILRRENLLERATTLGTRLLDALRPLEELDHVLEVRGVGLMLGIE
                     FT"
     gene            18848..19897
                     /locus_tag="K2F47_RS17010"
     CDS             18848..19897
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024808.5"
                     /locus_tag="K2F47_RS17010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_242904345.1"
                     /transl_table=11
                     /translation="MRRNIGIKTRAAAAGLAVTMVAACGIGNPSNKSDALTFVSTGSPF
                     QDYQNKAWAEPFTAQTGVKVRNDGPVDEARMKTMVEARKVSWDVVDTSAAAAVQYCGKY
                     LEKLDFSVIDKNVFPPGTVGDCGVPAYNYSLIFMYDKQKYKDNPPTKIGDFFDVQKYPG
                     RRIVPPEIAVGLLEAALLGDGVPEKQLYPLDLDRAFRKLQPIKKSTTFAKTYGQQQQMM
                     VDRQVDMALVLSARAYQSLKAGAPFEPVFDKTVVNWDDLVVPKGAPNKEQAMKFIAFAS
                     RNDPSAKLAQLASVQPINENIVPKYDPIQQRVNPFTPDRKHSIVRSNSDWWGKNFDEVT
                     KRYTTWLAG"
     gene            19905..20786
                     /locus_tag="K2F47_RS17015"
     CDS             19905..20786
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012738.5"
                     /locus_tag="K2F47_RS17015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_242904347.1"
                     /transl_table=11
                     /translation="MTTTTVKARSQVRGAPRTRGRAAWFVLPATALLLVFFFYPIATIV
                     WRSLTEPDAGLGNYTALLHDGLSVKVLVRTLVTALIVAATTLVIAYPYAYAMTKVRPRT
                     RAVLTVIVLLPFWTSLMARNFAWYMLEQRGGPIERFLGLIGFDGVVLLGTVAGVTVAMV
                     QVMLPFMVLPLYSAMEQIDKRLLDAAGSLGAPRWRAFARVYVPLSVPGMLSGFSLVFIM
                     TLGFYITPALLGSPQNSLISQVIGERVSKLLDFGGAGALGTVLLGVTLLVLFIVSRFGG
                     PARALGGAVTHD"
     gene            20779..21615
                     /locus_tag="K2F47_RS17020"
     CDS             20779..21615
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077045.1"
                     /locus_tag="K2F47_RS17020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_242904349.1"
                     /transl_table=11
                     /translation="MTEQAVETREKEPVRAQRDGGIGWGLRTAVGLTALLLIAPTVVVI
                     PMSFSGATTFEFPPKSWSLRWYKSFFGSEKWMYALLTSVQIGLLVAVAATILGVAVALG
                     LTRSRFRGRGAVRQLMMAPMIMPGIVVAIAIYGVFIRWQLNGTAIGFVIAHTVLALPFV
                     VTAVSTSLAGYDRTQDIAAATLGATAWTTFFRITVPQVLPGVLSGFAFAFVTSLDEVVV
                     ALFLQTPDIQTLPVQMYNSITLEIDPTIAAASSVMVVATTLVLLVPQLVRRERRTR"
     gene            21612..22751
                     /locus_tag="K2F47_RS17025"
     CDS             21612..22751
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131834.1"
                     /locus_tag="K2F47_RS17025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_242904351.1"
                     /transl_table=11
                     /translation="MNPSSKEAARGIRIKGVSKLYTGTSRPAVDEVSLDIADGEFMTFL
                     GPSGSGKTTMLSMLAGFVSVSAGSIEIDGRDVSRLKPHKRDLGVVFQQYALFPHLSVTK
                     NVAFPLQQRKMPKAEIAKRVAETLDLVHLGDYADRLPGQLSGGQQQRVALARAVVYEPR
                     ALLMDEPLGALDKRLRDQLQREIARMHRELGMTFIFVTHDQHEALTLSDRIAVFNEGRI
                     EQVGKPADLYERPETLFVAEFLGESTGFRGTVDKAAGILQCGENALRAPRLDPELDRCA
                     GVAVVRPERLRLHVDASEVHAEHNCVGATVTEIVYVGDRHQVGLKFADGTRGLASHPVG
                     SPLPAMPGEGVTVSWDPRHQAIVRDHAGGTAPAAVPAGA"
ORIGIN
        1 accggacggc ggcggcggtc gcgctggtgc tgctgagccc gctgtgggcg gtgatggcgc
       61 tgctcatccg gttggacgac ccgggccccg cgttcttctc gcaggtgcgc gtcggcctcg
      121 gcggccgggt gttccggatg ctgaagttcc gtacgatggt cgtggacgcc gagaagcgcc
      181 gccgcgacct caccgacccc gacccgtcgc gcggggtgct gttcaagctc cgcgacgatc
      241 cgcgcgtcac ccggctcggg tcgcggctgc gccgctggtc gctcgacgag ctgccgcagc
      301 tcgtcaacgt ggtgcgcggc gagatgtcgc tggtcggccc gcgcccgccg ctgcccgacg
      361 aggtggagcg ctacggcgag gacgtgttcc ggcgcctcgc ggtcaagccg ggcatgaccg
      421 ggctgtggca ggtgagcggc cggtccgacc tgtcgtggga ggagtcggtg cggctcgacg
      481 tccggtacat cgagaactgg tcgctgttcc tggacgtgca gatcctctgg aagacgctcg
      541 cggccgtgac acgcggctcg ggagcctact gacggccgct cgggcggggc cgcccgaccg
      601 gcggccccgg cccggcggcg aagggaagag atgagcatct cgatcgcgca cgtggtcggc
      661 gctcggccga acctggtgaa ggccgccccg gtcgtcgccg ccctcggcga cctggaccag
      721 agcgtcctgc acacgggcca gcactacgac gagcgcctgt cgaaggtgtt cttcgacgag
      781 ctgggcctgc ccgaacccga cgtgaacctc ggcgtcgggt cgggcgggca cgccgagcag
      841 acggcggcgg tcatggtggg gctggaacgc gagttcgtcc gccgcgcccc ggacctcgtc
      901 gtcgtgtacg gcgacgtgaa ctcgacgatc gccgccgcgc tggtcgcggc caagctccgc
      961 gtcccggtcg cccatgtgga ggccgggctg cgcagcttcg acatgacgat gccggaagag
     1021 gtgaaccggc ggctgaccga ccagctctcc gacctgtgcc tggtcaccag ccccgaggcg
     1081 atcggacatc tggcggccga gggaatcccg gtcgaccgcg cgcacctggt cggcaacccg
     1141 atgatcgaca cgctgctggc caacctcggc aagttcgaca ccgggaaggt tcgcgcggcc
     1201 cacggcctgc ccgagcggta cgtgctggcg acgatgcacc ggcccgccaa cgtggacgcg
     1261 cccgagacgg ccgccgcgct cgtcaggcac ctgcacagcg tcgccgacct cgccgacgtg
     1321 gtcattcccg tccacccgcg cgggcgcgcg aacctgatcg ccgccgggct ggacgaccat
     1381 ccgcgcgtcc acgtcctgga gccgctcggc tacatcgact tcatcgcggc cgtgcgcggc
     1441 gccgccgccg tcgtcaccga ctccggcggg ctccaggagg agacgacgat gctgcgggtg
     1501 ccgtgcctga ccgtccgccc caacacggaa cggccgatca ccatcaccca cggcaccaac
     1561 cgcctcgtca cgttcgagga actggtcccc gctgccggca aggcgctgag cgcaccggag
     1621 cggcaccacc tgtcccttgt ggggggacga ccccccacac cccccggaac ggaccgaatg
     1681 ccgccgctct gggacggcca cgccggggag cgcatcgccg gcgtcatccg cgactggacg
     1741 ggggccgcgt gatggacctc gtcgtgatcg gcctcggcta cgtgggcctc ccgctcgtgc
     1801 gggcggcgtg ccgggccggg ctgcggaccg gcggcctcga cctcgacgcc cgcgtggtgg
     1861 acggcctgcg cgccggacgc tcgcacgtcg acgacgtcgc gcccgccgag gtcgccgaga
     1921 tgctcggcca gggcttcgag ccgagcgcgg acgagcgcgt tctcgatggc gcgcggacgg
     1981 tggtgatctg cgttccgacc ccgctgtcga ccgagggcgg gccggacctg accgccgtcc
     2041 gcggcgccgc cgagaccgtc gcccggcacc tggagcccgg catgctggtg gtgctggagt
     2101 ccaccaccta ccccggcacc accgacgagg tcgtccgccc catcctggag aaatccggcc
     2161 tgatcgcggg cgaggagttc cacctggcct tctcacccga gcgcatcgac ccgggcaacc
     2221 ccgtctacgg catccggaac accccgaaga tcgtcggcgg tttcagcccg gcgtgcgcct
     2281 ccgctgccgc cgcgttctac ggcaagttcg tcgatcaggt ggtggaggcc aagggcaccc
     2341 gcgaggccga gatggccaag ctgctggaga acacctaccg gcacgtcaac atcgcactcg
     2401 tcaacgagat ggccgtgttc tgcgacgaac tcggcatcga cctgtgggac gcgatcgact
     2461 gcgccgccac caagccgttc gggttccagg ccttccgccc cggccccggc gtgggcggcc
     2521 actgcatccc gatcgacccg aactacctgt cgtacaaggt gcgctcgctc ggctacccgt
     2581 tccgcttcgt ggaactcgcg caggagatca acgaccggat gccccggtac gtcgtcgaac
     2641 gcgcgcagca gctcctcaac cgcgagggcc gggccctgaa aggcgcgaag gtgctgctgc
     2701 tcggcgtcac ctacaaggcc gacatcgccg accagcgcga atccccggcc cgccccgtcg
     2761 cccgccgcct ggcccgcctg ggcgccgacc tcagcttcca cgacccgcac gtcgcgtcct
     2821 ggcgggtgga cggcgccgac gtcccgcgcg ccgccgacct gcccgccgcg ctggagggcg
     2881 ccgacctgac gatcgtcctc accgggcacc gcggctacga cggcacgacg ctcgcccgcc
     2941 acgcgcgcct gctcttcgac gccgtcggcc acacccgcgg ggacccgggc ccggcgaccg
     3001 agctcctctg acgtccgcat ccggctacac cagcgggagc cggatgcgga cgaccgtccc
     3061 gccgcccggc gcggcctcca gcgcgacctc gccgccgtgc gccgccacca cggccgccac
     3121 gatcgacagg ccgagcccgg aaccgccccg gccgtgcgag cgcgacgggt ccgcccggta
     3181 gaagcgctcg aaggcgcggg cgcgctgctc ggcggtgagg ccgggccccg cgtcctcgac
     3241 ctccagcacc gcgccgccgt cccgcacgcc gtaccgcacg accgccgggg tgccctcggg
     3301 ggtgtggtgg cggacgttgg ccagcaggtt cgccagcacc tggcggagcc ggtcggcgtc
     3361 gccgcgcacc gcgagcgggc cctcgccttc gagcgcgacc ggatgctccg gcgcgacggc
     3421 gcgcgcgtcc gccaccgcgt ccccggcgag cgcgccgagg tcgacgggcc cgtgctccag
     3481 cgcccggccc tggtcgagcc gggcgagcag gagcagctcg tccacgagca cgcccatccg
     3541 ctcggcctcg gactcgatgc gcgccatcgc cttggcgagg tcctcgggac gccccgccgc
     3601 gccgcgccgg aacagctccg cgtagccccg gatcgtcgcg accggggtgc gcagctcgtg
     3661 cgaggcgtcg gcgacgaagc ggcgcagccg gtcctcggcg gcccgccgct cccggaacgc
     3721 ggcctcgatc tgggcgagca tcccgttgag cgcccggccg agccgcccga cctcggtccg
     3781 ccggtcggcc cgctccaccc gccgggtgag gtcgcccgcg ccgatggcgg cggccgtcgc
     3841 gccgaactgc tccagcggac gcagcccgcg cttgaccgcc agcccggcca cgagcgccac
     3901 cccgagcagg gccagcagcc cgaacacggt catcgagccc gcggtgcggc cctccagctc
     3961 ctccgactcg gcgttctgga cgccgatcac caggaagcgc gtgtgggggg ccgccccggc
     4021 gggccccggc agccaggcga cccggacgcg gaagcccgag tcgccgccga ccgtgcggaa
     4081 ccgctcgccg tcgggattgc cgtccgtcgc gcgcgccggg gccaggtcgc cgggcagttc
     4141 ggggaccggc ccgtaggtga cgctctggag gaccctgccg tccgccgccc ggatctggaa
     4201 cagcgacggg atggcgccct cggccgccag gacgcgccac agcgccgtca cgtcgtccgg
     4261 gacggccgcg gtccggagcg cctcccgcga cccgatcacg gcctcggcgc gcctgccggg
     4321 cgaggtgagc atgcgttcgt cccgcccgga cgtccagtcg cgcaccgccg cgaacgtcgc
     4381 cagcccggcg aggaggaggc cgagtgccgc cagggccacc gaggacagga tgagccgtct
     4441 gcgcagtgac acgtccgtga gtctcccgtc gcggtccggc ctggggctgt gcggactctt
     4501 agagaaccgt gtgagtcagg attccctgcg ttctctatga acgcgcggac ggcggccgaa
     4561 gagccgtccg actgacttgc ctcatggaaa cattctccag gttcgtgcta cggcacaagt
     4621 tgttcgtggc cgtggtctgg ctcgccgcca cggccgccgg agccttcgcg gtgacgcagg
     4681 tcggcgaccg cctcgtcgag gacttcgcgc ccgcgggttc ggccgcgcgc gacgccaacc
     4741 gggccatcga cgccacctac cgcagcgggg gcgagagcgc gcccacggtg ccggtcatcg
     4801 tcctgcccga gggcaggacc gtggacgacc cggccgtgcg gtccgcgctg ggcgccgcgt
     4861 tccagaacgc cgcgaagcgg ctggacgccc gcgtcgtctc ctacgccgac accggcgacc
     4921 ggcgcttcgt cggcgccgac ggccggacga ccttcggcct cgtctatccg cgccatcccg
     4981 ccggcgagcc ggtggacgag gcgcccgacc tcagtaagcc cctcgcacag atcatcgaac
     5041 cgtccctacc ggcgggctcc accctgcggg tgacggggat ggacctgctg gcggacggcg
     5101 cgggcgagga gggcgtcagc gtcctcaccg agacgctcgt cggcggtgtc ggcgcgctgc
     5161 tggtgctcgc gttcgtgttc ggctcgttcc tcgcgctcgt cccgctgctg atcgccgtcg
     5221 tgtccatcct cggctcgttc ctcgccgtgt acgggttgac cgagctcggc gaggtcaact
     5281 tcctcgtgca gttcgtggtc gcgctgatcg gcctcggcgt cgccgtcgac tactccctgc
     5341 tgctggtgac ccgctggcgg gaggagcgcg cccgcggcca gggcggcgag gaggccgtcc
     5401 accgcgccat ggccaccgcc ggacgctcgg tggtgttcag cggcgtcgcg gtcagtatcg
     5461 ggctgatcgt catgctggtg ctgccggtcc cgttcctgcg cagcatcgcc tacggaggtg
     5521 tgatcatccc gtccgtcagc gtcctggcga cgctgacgct gctgccgatc atcctcgcca
     5581 ccgccgggtc gcgcctcgac tggccccggc tgcgcaagga ctcgcacgcg agccgcgcct
     5641 gggcggcgtg gacccgcggc gtcgtccggt tccgcttccc ggccgcgctg ggcgcgatcg
     5701 cggtgctggt cgcgctggcg ctcggcggcc tgaacatcca cctcggcgag gcgggcagca
     5761 gcgcgggcgc caggagcgga cccgcccacg acgggctcgt cgcgctgcga tcggcgggca
     5821 tcggctcggg agtcctcacc ccggtcgacg tgctcgtccc gccggggggc acgcccgcgt
     5881 cggcggcctc gcggctcgcg gacgtggcgg gcgtgcggac ggccgtcgcg ccgtccggcg
     5941 aggcgtggcg gcagggcgga tcggcgctgc tctcggtgat cccggtggac gagggcggta
     6001 ccaacgcagg ccacgacacc gtccggcgga tccgcgaagc ggtgccgccc ggcgcccacg
     6061 tgggcggcga ggcggcgagc gacatcgact tcgtcgacca ggtctacggc gtgttcccct
     6121 ggctgctcgg cctgatcgcg ctgctcacgt tcgtgctgct ggcgcgggcg ttccggtcgc
     6181 tggtgctgcc gctcaaggcc gtcgcgctga acctgctgtc gctcgccgcg gcgctcggct
     6241 cggtcacgct gatctggcag gaggggcacg gcagcgacgc ggtctggggg gtccccgcca
     6301 ccggcgcgat cggcgcgttc atcccgtgcc tgatcttcgc gttcctgtac gggctgtcga
     6361 tggactacga ggtgttcatc ctcgcccgca tccgcgagga gtacgagcgc accggctcca
     6421 ccgaggaggc gatcgtggag ggcctcggcc ggacgggacg cctcgtcacc agcgccgcgc
     6481 tgatcctctg cctggcgttc gcctcgatgg ccgccgcgcc gatgaccgag gtcaaggtct
     6541 tcgccaccgg cctcggcctc ggcattctgc tggacgccac gatcgtccgc ggcgtcctcg
     6601 tgcccgcgct gatcgcgatg ttcggcgact ggaactggtg gctgcccggc tgggccgcgc
     6661 ggctcctgcg ggtcgcgccg tccggccctg cctccattgg cgccgccggt cagccgtcct
     6721 tcgggagccg cagcacgtag ccgacgcgcg ggatcgtgtg gatcagcggc ggctcgaccg
     6781 cgtcgacctt gcggcgcagg tagctgacgt aggtctgcac gaccccgtcg ctgccgccgt
     6841 ggtcgtggtt ccacacgtgg tcgaggatct gccgcttgct cagcacccgg cccgcgttga
     6901 cgacgaggta gcgcagcagg cggaactcgg tcggcgtgag gtcgagcggc gcgtccccgc
     6961 ggcgcacctc gtaggcgtcc tcgtcgatga cgaggtcggc gaacgccagc cgcgcctccg
     7021 ccggccgcgc gccgctcgtc cggcgcagca cggtccggac gcgggcgatc agctcctcca
     7081 ggctgaacgg cttggtgacg tagtcgtcgc cgcccgcggt cagcccggcg atcttgtcct
     7141 cggtggcgtc ccgcgcggtg aggaagacga ccggtgccgc gcgtccctcg cgccgcagcc
     7201 ggtggcacag gtccaggccc gagccgtccg ggagcatgac gtcgagcacg atcaggtccg
     7261 gacggaagcc ggtgacccgc gcggccgtct cggcgcacgt cccggcggtc tcggcggtgt
     7321 acccctcgta tcgcagcgcc gtggcgacca ggtcggcgag gtagggctcg tcgtccacga
     7381 cgaggacgcg ctctgcgggc tggttcatgg ggccaagtgt gaaccaggga gcttagagaa
     7441 cgcagggaac gccctgcggc gggccggccc gcccttggcc ctcgttccgc ccgtgaggac
     7501 caagggcgct gccgggcgcg gggctcagtt ccgcctggcc tggccgatca cgccgcacgc
     7561 gaagcggccg cccgcgtcgc ccgtggcgag ggacgcggtg tcgggcccct tcttgccgtc
     7621 cgcggtggcg tagcggtcgg ggatgttggc gtggttgtcg ggcagcgcgt ggatgatgat
     7681 cgcgctgccg tcggcgtcca ggaggtgctt ggcctggaag cggtcggtga cggtctcgcc
     7741 ggagcccttc ccgctctcgt cgatcagcag cgtcggcagg tcgccggagt gcgaggggtg
     7801 ggtgtgggcg gggtcgaggt tcaggtggcc gcccgcggtg aagaacgggc tgaccttgcc
     7861 ggtgttgggg tcgacggcct cggggtcgca cttgccggtc gtgtggacgt ggaagccgtg
     7921 gaagccgggc ggcaggttcc acgcccggac ggtcagcttc tcgtgggtcg ggccctggtc
     7981 ggcgacggtg agcgcgccga cgacgttgcc cttgacgtcg cggatctggg cggtgagggc
     8041 gcggtgtccg ccgtcggtgg cggcgttgac ggcggcggag accgcgaccg tccccgccag
     8101 cccgccgacc gtggccagca ccgtgagatg ggcgaccgaa aggatcttct tcatgtccgt
     8161 ccctttccgg atgggcgggc aactgcggca aggcgcccgc cggggccctt ggtagcgcgg
     8221 caggccctgt ggcgcaaggg ttccggcgat tcgggcaggc aaggaacagc ggttggcagc
     8281 gagggtcaga acgcaggtga aggggtctgg tcttatccac aaattaatag gaaacttacc
     8341 tatcggatcg gccccacccc tgtccccgcc aaacgggagc caacgatgtc cgtcaggacc
     8401 caccccacgt cccacgcccc ccgcacagcc tcccattccc gcccgtacgt cctcgccgta
     8461 ggacggttgt tcctggcctg gatcttcctc tgggccttcc tcgacaagac cttcggcttc
     8521 ggcaagccga ccaagtccgg ctggctggac gggacctccc cgtccaaggg cttcctcagc
     8581 cacaccgaag gcccgttcaa gggcatgttc cactccatgg caggtcagac ctgggtcgac
     8641 gcggccttcg tgttcggcct cggcggtctc gggatcgcgc tgaccctcgg catctgcctg
     8701 cgcatcgccg cggcgggtgg aacgctcctg ctgctcaacc tgtgggccgc ctcgctgtgg
     8761 cccgaggcca acccgttcat ggacgagcac tggatctacg cggccctgct catcgcggcc
     8821 gcggcggcca acgccggtga cgtcctcggc ctcgggggcc cctggtcccg gacggccctc
     8881 gtccgccgtt acccgttcct gcgctgaggc cgcctccccg cgctgatttt cagcgttgag
     8941 ccaacctcac ggcgggccgt cgtaatggcc ggtccgaaaa aggcgacccg ccgtgagggg
     9001 acagcgacag atggacccgc acgtaagtgc ggtgtcgccc gttaggaagg gtccaccgga
     9061 gggagacggt cgagggtggc cgcgtactcg gccaccagct ccccgacgat ctccgccgcc
     9121 ggaaggatct cggtgacgag gcccgccgac tgcccggcct cgaccttgcc ccgcgcgacg
     9181 tcgccctcga acgccgccat ccgcagcgtg gacgcggcga acacggcgcg ccgcaggtcc
     9241 agctccgcgc cggtgcgctc cagctcgccc atccggtcgg cgaactcgtt ggccagcagc
     9301 cggatcatcc cgatctggtg gccgaccgtc cgggtgtcgc cgacgcccgc cgcgagcacg
     9361 gcctccttgt aggcgggatg caggttcgac tcgacgctcg cgaggaagcg ggtgccgaac
     9421 tgcgcgccgt ccgcgccgag cgacagcgcc gccgcgaggc ccgcgccgtc ggcgaagccg
     9481 cccgaggcga cgatcgggac gccgggcgct gacttcacca ccgaccgcac catgaccagc
     9541 gtcgacacca gcgcggcggg cggatggccg cccgcctccg cgccgacgac gacgagcccg
     9601 tccaccccgg cgcccacggc cttggcggcg tgctcctcgc ccgcgacgac gtgcaggcag
     9661 gtcgtcccga ggtccttgaa ccgcggcagg tagcgcttcg ggccgccctg cgaggcgatc
     9721 aggaccggca cccgccgctc gcacagcagg tcgatgacct cctccacgcc cttgcggtac
     9781 agcggcaggt tcaccgcgta cgggcggtcg gtgcccgcct cgacctcgtc gatcgcgcgc
     9841 tccaggtcgg gcagccgcat cggcccggcg gcgatcacgc cgagcccgcc cgcgcgcgag
     9901 accgcgagcg gcagcgccga gcccgacgag gcccacgaca tcccggcctg gacgatcggc
     9961 agctcggtcc cgaggagccg ggtgagcggc gtgtcgatcc tcacccgtcc tccagcagtc
    10021 tccgcgcgtg ctcggcgagg tgccgcttct gcaccttcga gctggccgtc atgccgaact
    10081 cctcgaagcc cgcgacgacc cgcaggtggc ggggcgcctt gaacccggcg agccgctcgc
    10141 gcgcccagcc gaggatctcc tccggctcgg cctcgcggcc ctcggtcagc acgacgaacg
    10201 cgaacggcac ctcgatcagc cgcgcgtcgg gcacgccgac caccgccgcc tgcttgatct
    10261 tcggatggcg gtgcaggcag tcctcgacct cggtcgggga gacgttctcg ccgccgacgc
    10321 ggatcaggtc cttcgcgcgg ccgacgaact ccagccgccc gtcggggccg agccggccga
    10381 ggtcgccggt ggacagccag ccgccggggg agagggcggc ggcggtctcg tccggcatct
    10441 cgaagtagcc ctgcatgacg ttccatccgc gcacgaggat ctcgccgacc tcgccggtcg
    10501 gcacctcgcg cccggtctcg gggtcgcgca gccgcacctc gacgccgggc tcgggcagca
    10561 tccgcccgga cgcccgcacg tcctcgggct cccaccaggc cgactgcgcc acgttcggcg
    10621 acgcctccga cagcccgtac ccgacgacgc actcggtcgc gcccagctcg tcgatgatcc
    10681 gccggacgat cccgggcgac gccgccgccc acgcgccgcg caggctcagc ttccgtcccg
    10741 gccggtcggg gtggtccagc agcatcagcg cgatcgtgtc gttgccggag aagtgggtgc
    10801 agcgctcggc ctccatcagc cgcagcgcct caccggcctc gaaccggtcc atggtcacga
    10861 gcgtcgtgac gtgctggagg cacgccagca ccgacaacgt gctgcccgcc gcatggaaga
    10921 acggccgcgc gctgtggaac cggtcgcccg cgcgcagccc gagccgcgcg ccggagaaga
    10981 acgcgtccgc gcacatgttg cggtgcgtca gcaaaacgcc tttcggatag gacgtcgtgc
    11041 cggaggtgta ctggatcagc agcacgtcgc ccggcgccga gcacggctcg acgggcggcg
    11101 cgtccacggc gaggaactcc tcccacgacc gcgcggcgga cggcacgtcc gctccgagca
    11161 cgaccacatc cttcaggtcg ggcagcgccg ggtcgggcag ggccttgtcg atgccggggc
    11221 agatctgccg cagcatcgcg cagaactcgc tgctgaggaa ccggtcggcg gtgaacagca
    11281 gcttcgcgcg ggactgccgc agcacgtagg cgatctcgtc ggcgcgcagc cgcgtgttga
    11341 ccggtaccgt caccgcgccg agcgagccga tcgcgacgaa cagcgacacc cagcgtggac
    11401 cgttcccgag gcagaccgcc acatggtcgc cccggccgac accggcggcg gccagcgccg
    11461 cgcggacggc cgtgacctcc gcgtccagct ccgcgtaggt gatggtcccc tgcgcggaga
    11521 cgatcgcctg gacgtccgcg cccacggccg ccgcgcggcg cagcgccgcg tcggcggtca
    11581 gcggacagat cgcctccagg ttcaccggcc ctcctccttc acagtctgct cccccgacgc
    11641 cggacggata gacccctcaa aggcgctgac gccgttgcgc caggcgccgt cggccaggca
    11701 gcgctcgatc gcggccatct cgatcctgat gccgttggcg aggtcggtct cggcgccgag
    11761 gtcgatcgcc tgcttggtga gcgcgatcgc gagcggcggc gcgtccgcga tcgtgcgggc
    11821 gagccgctcc ccggcctcgg ccagctccgc cgccgggacg agccgcgcga ccagccccac
    11881 ggcggcggcc tcctcggcgc ccatcgtgcg ggaggtgaac agcagctcct tcgcgcggcg
    11941 cttgccgatc acccgctgga gccgctgcgt cgcgccgacc gtgccccagt gcggttcggg
    12001 gaaccggaac gtggcgtcgt cggaggcgac cacgaagtcg caggacatgg cgatctcccc
    12061 gcccgacccg acgaccgggc cctgcacgag cgcgaccacg ggcttggagc agcgctcgat
    12121 cgcctcgtag gcggcgaagg acgcgagccg ccgcgagcgc acccacgcct cgtcccggcc
    12181 cttgcgctcg cgcaggtcgg cgcccgcgca gaacgcgggg ccgttcgcgc gcagcagcac
    12241 cgcgcggacg ccggggtcgg cgtccagctc ggcgaacgtc tcgcgcagcc ggtggcacat
    12301 cgggaggttc agcgcgttgc gcgcggccgg ccggttcagc acggcgtgcg ccacgccgtc
    12361 ctcccggcgc accagcacgg gatcgtcgtc gctctcaacg gccatgctca aatcgtccct
    12421 tcgtcgcgaa gccgggagat ctccgcctcg cccagcccga gcagctcgcc gagcacggcg
    12481 gcggtgtcgg agccgagcag cggcggcgcg gcgggctccg gatcgtcgta gccgtcgatg
    12541 cgcaacgggg tgcgcagcgc cggaaagcgg ccctcgacgg ggtgctcgaa gtgccgcacc
    12601 atgccgcgtt ccaccgtgtg ggggtcggcg agcgcctccc gcaccgagtt cacctcgccc
    12661 gcgggcacgc ccgccgcgcg cagtgccgcc gccagctcgt cgcgctgcca tccggcgaac
    12721 gcctcggtga gggcggccgt gacgtgagcg cgccgggcga cgcgtccggc gttggtggcg
    12781 aggtcggggt cggcggccag ctcgtccagg ccgaggacct tgcacagcgg gcgccagtgg
    12841 tggtcgctgc cgctgatgtg cagccaccgg ccgtccgcgc actcgaacgc ggcggacggc
    12901 acgcgccccg gatgcccggt gccggtgcgc accgggtcct cgtccagcgc gaacagccgc
    12961 gcggcggcca ccgcgagcag gctgacctgc acgtccatca tcgcgaggtc ggcatgcccg
    13021 ccgcgcccgg acgcgtcgcg cccggccagc ccggccagcg cggcgatcac gatccacagc
    13081 cccgaggtga ggtcggcgat cggcacgccc gccttggcgg gcggcgtgcc cgggtgcccg
    13141 gtcagcgcca tgacgcccga cagcgcctgg aagatcgtgt cgtagccctt gcggtcggag
    13201 taggggccgc tctggccgaa cccggtcccc gacacataca ccaggcgcgg gttctccttc
    13261 gccagcgcct cgtagccgag cccgcgccgc tccatcgcgc cgggcaggaa gttctcgacc
    13321 aggacgtcgg cctgccgggc gagcccccgc gcgatctcct gtccccgggg ggtggacagg
    13381 tcgagcgtga tcgagcgctt gccccggttg aaggcgaaga agtaggcgct ctccccgccg
    13441 ggcagcttcg gctcgaacag ccgcgactcg tcgccgccgc ccggccgctc caccttgatc
    13501 acctcggcgc cgaggtcggc gaggatctgg gtggccatcg ggccggcgag cacccgggag
    13561 aagtccagta cgcggattcc gtccagtggc ctcacgggcg gaacccgcgc atgatcgcgt
    13621 tcacgtccgc gccggtgcgc atggcctcct cgaacggcag gtcggcgacc cggtagaaca
    13681 gcgccttggc cgcgatcatc gcgtcggcgt tgacctcggc ccagccggcg gcgatctcca
    13741 gcgccgcctc gacctccgcg ccgggctcga cgacccggtt ggcgatgccg cgctcggcca
    13801 gctccgccgc gctcaggatg cggccggtgc tgatcagctc gaaggcgaac ttgcggccga
    13861 agtgccgctg caacccggtc atcacgaccg ccgggaccag cgagtgccgc agctcggggt
    13921 acccgagctt ggtgtcggac gcggcgacca tcatgtcgca gccgatcgcg aggcccgcgc
    13981 cgccgcccat cgcgtgcccc cgcacggcgg agatcaccgg cttggtgagc tgctgcggga
    14041 gcatctgact gcgcatggtc agctccgcgc gccggacgac cgcggtctgg tcgtcgggcg
    14101 tcaggtcctt gaactcggtc aggtcggcgc ccgcgcagaa cgcgcggccc gtcccggtca
    14161 gcacgaccgc gcggacggcg ccgtcggcgt cggccgcgcg cagcgccgcg agcagcgcgg
    14221 cggtgagctc ggtgttcagc gcgttgagct tggcgggacg gttcagccgc aggacccgga
    14281 cggcgccgtg gtcctccgtg accagcacgt cggtcgacgt gtcacgcgtg agcatcctgg
    14341 aactccttcc ggcaggccgg gccgaacccg gcgcgggcga ccatgctgta gagggaccgg
    14401 ccgagcgcct cctcgcacat ccgcgacgcg gccatgacct tgtcgaggtc gaggccggtg
    14461 tccacgccct cggactccag caggttcacg aggtcctcgg tgcagacgtt ccccgtcatg
    14521 ccctgcccgt actggatgcg ggtggggtgg ccgcccaccc cgccgaggga gctgtcgaag
    14581 tcgcggcacc cggcctccag cgccgccacg cagttggcga tgcccgagcc ccgggtgttg
    14641 tggaagtgcg ccacgaccgg aatgtcggga cgcgccgacg acacgcgctt gaacagggat
    14701 ttcaccgcgc tcggcgtggc gagcccggtg gtgtcgccga gcgtgaccat gtccacgccg
    14761 aggtcggcga agcgcgccgc gtcatcggcg acgacgccgg ggtcgacctg cccctcgaac
    14821 gggcagccga acgccaccga cacgaccccg accagcttga accggccgcc ggcgagccgg
    14881 accatctccg tgatccgctc ccactgcttt tccctggtgg tgcgcatgtt gcgctcggtg
    14941 tgcgactcgg tcgccgagac cagcaggctc agctcgtccg cgccgtgccc ggcgtcgagg
    15001 tcggcgaggg cgcgctcgac ggcgcgcggg ttcgggcagg tcgccttgta cgacacgccc
    15061 gccggccggg ggagcccggc gaggacctcg ctcgcgtccg agaacgccgg gacccgcccg
    15121 gggtggctgt aggacgtcgc ctcggcgcgg cggaaccccg cgtcggcgaa cgcgccgatc
    15181 agcgcgatct tgacgtccgc cgggacgtgc gtctcctcgt gctgcaggcc gtcacgggcg
    15241 aagcattcgc agatcgtgac tccgtcggtc atgtacggcc gcccctcctg aagtgtcgcc
    15301 acacgggtca tcaccttgag ggatacacgg atggtgttga tgatgtcaac accggaggcc
    15361 gcgtcgcgca cgatgagtca cgagcggtcg cactcagtgt tcggcacgct ccagtgcgcg
    15421 gcccacggcg gccagcttgc gcagcgccga gtcgaggact tcctgctcgt caggggtgag
    15481 gcaggccagg aacgcctcgt tgcggtcgtt ggcggccgag atcaaacctc ggtagagcga
    15541 ctttccgctg cgggtcagcg agagctgcgt gctgcggccg ggccccggct ggcgctccag
    15601 caggccgcgc tcggtcagct tggtcaccac ccggctcatc tgtgccttgt ccagcccggc
    15661 gagccgggcg agctggttga cggtctgcgg ctcgtcggcg ccaaggagtg cgaccgtccg
    15721 ccattcgtgc aggctgacgc cgtattcgcg gcggtagcgg agggcggcgc tgcgcgacag
    15781 cgcgttcgcg acgcggtgca gccggtagga caatagctcc cggatcggca ggagcgcggt
    15841 cgtttcggcg gcgggatccg cggagcgggc gggatctgcg ttcatgcgcc cactgtaaag
    15901 ccgcgaatcg atacctcgga aggtgttgac aaatacaaca cttggttctc agactgctga
    15961 cctgtaccga tcaccgtcgg ttgagcagcg taccgagtga gccgtagacc gaggaggggc
    16021 gccaatgccc gcagagccgt ccaccgccac cctgttgatc gacggggagt ggcgcccggg
    16081 gcccaccgcg ttcgaggtgg tggatccggc gacgctggag gtcgtcgcgc acgccgccga
    16141 cgcggggccc ggcgaggcgc tcgcggcgct ggaggccgcc tgcgcggcgt tcccggcctg
    16201 gcgcgcgacg ccctccgagg accgcgcgac cgccctgcgg gccgccgccg ccgcgatccg
    16261 cgccgccgcc gagccgctcg ccgagctgat gacgagcgag aacggtaagc cgctgcacga
    16321 ggcgcgcggc gaagtcatgg gcagcgcccg gatgctcgac tgggccgccg aggagggccg
    16381 ccgggccgac gggcgcgtca cccccggcaa ccaggccggt cccgggctgg tgctgcgcac
    16441 cccggtcggc cccgccctcg cgatcacccc gtggaacttc cccgcgagca tgctggtccg
    16501 caaggtcggc ctcgcgctcg ccgccggctg cccggtgatc gtcaagcccg ccgagcagac
    16561 cccgatgatc ggcaccgagc tcgtccggat catcaacgag gccgccgcgc tgcccgccgg
    16621 cgtgctccag tcgatcacca cgacgcgccc ggccgaggtc gtcggcgcgc tgctggacga
    16681 cccgcgcctg cgcaaggtca gcttcaccgg ctcgaccgag gtcggcctcg gcctgatccg
    16741 ctccaccggg gcgcggctgc gccggacctc gctggagatg ggcgggcact ccccggcgat
    16801 cgtgttcggc gacgccgacc tcgccaccgc cgccgcggcc gtcagcgcgg ccaagttcgc
    16861 caacgccggg cagagctgca tcgcgatcaa ccggctgtac gtccagcgcg gcgcgctgga
    16921 ggagttcctg ccgctgctgc tggagcgggt cgcggcgctg cgcctcggcc acggcgccga
    16981 cgagggcacg acgctcggcc cgctgatcga cttcgccggc ctcgacaagg tcgagcggca
    17041 cgtcaccgac gccgtcaagc gcggcgcgac ggtcgccgcc gggggccgcc gctggaccgg
    17101 cgagggcgcg cgtcccgggc tgaccggcgc gttctacgag ccgaccgtcc tgaccggggt
    17161 ggacgactcg atgctgatca gctccgagga gacgttcggg ccggtgctgc cgatctacgc
    17221 cttcgacgac gacgaggacg cgctgcgccg cgccaacgcg agcgagtacg gcctggccgc
    17281 ctacgtcttc ggctcgggcc tcagccggat ctggcgggcc gtggagtccc tggacttcgg
    17341 catcgtcgcg gtcaacgacc ccgcgccggt gcgtcccgag ctgccgttcg gcggcatgaa
    17401 gaacagcggc caggagcgcg agggcggcag cgagggcatc gacgcctacc tggagaccaa
    17461 gtccgtttcg gtgaggctgt gaggacggcg ccatgacgat ggaacagcac gccacccgcg
    17521 agcaggcgga cgcgacggac ctcgccgagc gggacgtccg gacgatcatc cacccgcaca
    17581 gcgtgatcgg ggagccggcc gagccgctcg tcctcgaccg cggcgagggc gccgtggtct
    17641 gggacgtgca gggccggtcc tacatcgacg gcacctgcgg gctgtggcag tgcccggtcg
    17701 gccacggccg ccgggagctg gccgacgccg ccgccgcgca gatcgccaag ctggagttct
    17761 actcctcgtt cggcgactac tccaacgagc cgtcgatcag gctggccgag aagctgctgg
    17821 agctggcccc cgcgggcctg cggcgggtgt tcttcaccaa cggcggctcc gagggcaacg
    17881 agaccgcgat caagctggcg cggctcgccc agcaccacgc gggccacccg gagcgcacga
    17941 tcgtcctcgc ccgctcggcc gggtaccacg ggatgggcgg cggctcgctc gccgcgaccg
    18001 gcatcgaccg gctgcgcgag ggctacgggc cgctcgtccc cggcatcgag ttcctcggca
    18061 agccgcacgc cgtcgccggg gaccccggca ccgcggaccg gctgatcgcc gagctggagg
    18121 agcggatcga gtcgatcggc ccggagcgga tcgccgcgtt catcggcgag cccgtcctcg
    18181 gcgtcggcgg catggtcccg cccccggacg gctactggcc gcgggtgcag gaggtcctgc
    18241 gccggcacgg catcctgctg atcgtcgacg agatcgtcac cgcgttcggc cgcaccggcc
    18301 actggttcgc cagcgagcgg tacggcatcg agcctgacat gatcgtcact gcgaagggcc
    18361 tgtccagcgg atacattcca atgggggccg ttctcatcgg ccagcgggtc ctcgacctgg
    18421 caggaggcgc ggccttcctg cacggcttca cctacaacgg ccatccggtc ggcgccgccg
    18481 tcgctctcgc caacatcgag attttgcggc gggaaaatct tttggaacga gccaccacgc
    18541 tcggtacgcg gctgctggac gcgctgcgcc ccctggagga gctcgaccac gtcctcgagg
    18601 tgcgcggcgt cgggctcatg ctcggcatcg agttcaccgg gggcgacacc tccggggtgc
    18661 aggccggggc gcgcgccgag ggcgtgatcg tccgcgcgtc cggcacaagc atcgtcctgt
    18721 ctccgcctct ggtgatcaca gaggagcagg tggataccct cgcgcgggtc ctgatcgagc
    18781 aggtcagggc ggcgcactaa gtcaacgaat ccgtcgggga cccactaccg agcactggag
    18841 gaagaccgtg cgtcggaaca taggcatcaa gaccagggcg gcggccgctg gtctggccgt
    18901 gaccatggtc gcggcatgcg gcatcggcaa tccctcgaac aagagcgacg cgctcacgtt
    18961 cgtgtcgacc ggcagcccct tccaggacta ccagaacaag gcgtgggccg agccgttcac
    19021 cgcccagacc ggggtgaagg tccgcaacga cgggccggtc gacgaggcgc gcatgaagac
    19081 gatggtcgag gcgcgcaagg tcagctggga cgtcgtcgac accagcgccg ccgccgccgt
    19141 gcagtactgc ggcaagtacc tggagaagct cgacttctcc gtcatcgaca agaacgtctt
    19201 cccgccgggg acggtcgggg actgcggcgt cccggcgtac aactacagcc tgatcttcat
    19261 gtacgacaag cagaagtaca aggacaaccc gcccaccaag atcggggact tcttcgacgt
    19321 ccagaagtac cccgggcggc ggatcgtccc gccggagatc gcggtggggc tgctggaggc
    19381 ggccctgctc ggcgacggcg tccccgagaa gcagctctac ccgctggacc tcgaccgcgc
    19441 gttccgcaag ctccagccga tcaagaagtc caccaccttc gccaagacct acggccagca
    19501 gcagcagatg atggtcgacc gccaggtcga catggccctg gtgctgtcgg cccgggccta
    19561 ccagtcgctc aaggcgggcg ccccgttcga gcccgtcttc gacaagacgg tagtgaactg
    19621 ggatgacctg gtggtgccca agggggcacc gaacaaggaa caggcgatga agttcatcgc
    19681 cttcgcctcc cgcaacgacc cgtcggcgaa gctcgcgcag ctggcctccg tccagccgat
    19741 caacgagaac atcgtgccga agtacgaccc gatccagcag cgggtcaacc cgttcacgcc
    19801 cgaccgcaag cactcgatcg tgcgctcgaa ctccgactgg tggggcaaga acttcgacga
    19861 ggtcaccaag cgctacacca cctggctcgc ggggtgaggc atccatgacc accacgacgg
    19921 tcaaggcacg gtcgcaggta cgcggggcac cgcgcacccg ggggcgcgcg gcctggttcg
    19981 tcctgccggc gacggcgctg ttgctggtgt tcttcttcta tccgatcgcg acgatcgtgt
    20041 ggcgcagcct caccgagccc gacgcgggcc tcgggaacta cacggcgctg ctgcacgacg
    20101 gcctgtcggt gaaggtgctg gtcaggacgc tggtcaccgc gctcatcgtc gccgcgacga
    20161 cgctggtcat cgcctacccg tacgcgtacg cgatgaccaa ggtccgcccc cggacccgcg
    20221 cggtgctgac ggtgatcgtc ctgctgccgt tctggacgtc gctgatggcc cgcaacttcg
    20281 cctggtacat gctggagcag cgcggcgggc cgatcgagcg gttcctcggc ctgatcgggt
    20341 tcgacggcgt cgtgctgctc ggcaccgtcg cgggcgtcac ggtggcgatg gtgcaggtga
    20401 tgctgccgtt catggtgctg ccgctgtaca gcgccatgga gcagatcgac aagcggctgc
    20461 tggacgcggc gggcagcctc ggcgccccgc gctggcgggc gttcgcgcgg gtgtacgtcc
    20521 cgctgtcggt gccgggcatg ctgtcgggct tctcgctggt gttcatcatg acgctcggct
    20581 tctacatcac cccggcgctg ctgggctcgc cgcagaactc gctgatctcg caggtgatcg
    20641 gcgagcgggt gagcaagctg ctggacttcg gcggcgcggg cgcgctcggc accgtcctgc
    20701 tcggcgtgac gctgctggtg ctgttcatcg tgtcgcggtt cggcggaccg gcgagggccc
    20761 tcggaggggc ggtgacccat gactgagcag gctgtggaaa cccgcgagaa ggaaccggtc
    20821 agggcgcagc gggacggcgg gatcggctgg ggtctgcgga cggccgtcgg gctgaccgcg
    20881 ctgctgctga tcgccccgac cgtggtggtg atcccgatga gcttctcggg ggccacgacg
    20941 ttcgagttcc cgccgaagtc gtggtcgctg cgctggtaca agtcgttctt cggctccgag
    21001 aagtggatgt acgcgctgct cacctcggtc cagatcgggc tgctggtcgc ggtggccgcg
    21061 acgatcctcg gggtcgcggt cgcgctcggg ctgacccggt cgcggttccg ggggcgcggc
    21121 gccgtccggc agctgatgat ggcgccgatg atcatgccgg ggatcgtggt cgcgatcgcg
    21181 atctacggcg tgttcatccg ctggcagctc aacggcaccg cgatcggctt cgtgatcgcg
    21241 cacaccgtgc tcgcgctgcc gttcgtggtg acggcggtgt ccaccagcct cgccgggtac
    21301 gaccggacgc aggacatcgc cgccgcgacc ctcggcgcca ccgcgtggac gacgttcttc
    21361 cgcatcacgg tcccgcaggt gctgccgggc gtgctgtccg gcttcgcgtt cgcgttcgtc
    21421 acctcgctcg acgaggtcgt cgtcgcgctc ttcctccaga cacccgacat ccagaccctg
    21481 ccggtgcaga tgtacaactc catcaccctg gaaatcgacc ccaccatcgc tgcggcgtcg
    21541 agcgtgatgg tggtcgcgac caccctcgtg ctgctcgtcc cgcagctcgt gcgccgcgag
    21601 cggaggacac gatgaacccc agcagcaagg aagccgcccg cggaatccgc atcaaggggg
    21661 tctccaagct ctacaccggg acgtcgcgcc cggcggtgga cgaggtgtcg ctcgacatcg
    21721 ccgacggcga gttcatgacg ttcctcggcc cgtccgggtc gggcaagacg acgatgctgt
    21781 cgatgctcgc cgggttcgtg tcggtgtcgg cggggtcgat cgagatcgac ggccgcgacg
    21841 tgtcgcggct gaagccgcac aagcgcgacc tcggtgtggt gttccagcag tacgcgctgt
    21901 tcccgcacct cagcgtcacc aagaacgtcg cgttcccgct ccagcagcgc aagatgccga
    21961 aggcggagat cgcgaagcgg gtggccgaga cgctcgacct cgtccacctc ggcgactacg
    22021 ccgaccggct gcccggccag ctctccggcg gccagcagca gcgggtcgcg ctggcccgcg
    22081 cggtcgtcta cgagccccgg gccctgctga tggacgagcc gctcggcgcc ctcgacaagc
    22141 ggctgcgcga ccagctccag cgggagatcg cgcggatgca ccgcgagctc ggcatgacgt
    22201 tcatcttcgt cacccacgac cagcacgagg cgctgacgct ctccgaccgc atcgcggtct
    22261 tcaacgaggg ccgcatcgag caggtcggca agcccgccga cctgtacgag cggccggaga
    22321 cgctgttcgt cgccgagttc ctcggcgagt ccaccgggtt ccgggggacg gtcgacaagg
    22381 cggccgggat cttgcagtgc ggcgagaacg cgctgcgggc gccgcgcctg gacccggagc
    22441 tggaccgctg cgcgggcgtc gcggtcgtgc gtcccgagcg gctgaggctg cacgtcgacg
    22501 cgtccgaggt gcacgccgag cacaactgcg tcggcgcgac cgtcaccgag atcgtctacg
    22561 tcggcgaccg gcaccaggtc gggttgaagt tcgccgacgg cacccggggc ctcgcctcgc
    22621 acccggtcgg ctcgccgctg cccgcgatgc cgggcgaggg cgtcacggtg agctgggacc
    22681 cccggcacca ggcgatcgtc cgcgaccacg cgggcgggac cgcgcccgcc gccgtcccgg
    22741 ccggggcctg atccaccgcc ctcccaccgc accgatccac cttcgcgaat ggagttcctt
    22801 ccgtggcacc gcacaccgac ggcaccgcga ccgacccgcg ctacgagcgc atcaccgccg
    22861 gcccgcccga ggtgaccgac ggcttcctcc gggacgtcct gcgggacggc tacgggctcg
    22921 gcagtgtcac gaggcccgtc gcgctccggc cgctggcggg cgagaccgac cgcaacaccg
    22981 aggtcaccga cgagaccggc gcgcgctacg tcctgaaggt caccgggccg ggggagcggc
    23041 gggcggcgga gttccagacc gcgctgctcg accatctcgc cgcgcgcgac ctcgggttcg
    23101 aggtgccgcg cgtcgtcccc ggcctggacg gcgcgcggga ccggatcgtg gacgggctgc
    23161 tcgtccggat gctgacgttc gtgtccggcg tcccgctggc cgaggcgccg cgccgctcgc
    23221 ccgagctgct cgccgacgtc ggcgcggtct ccgggcggct cgccgccgcg accgccgagt
    23281 tcacccacca ggacccgccc gaggcgcact actgggagtt cgcgcacgcg ggcacggcgc
    23341 tcaccgactc gctgccgcac gtcgaggacc cggacctgcg cgcggccgcc gcgctcatcc
    23401 aggcccgcta cctcccgctg gtggacgggc ggctggacgg gctgccggtc gcggtcgtcc
    23461 accacgacct caacgtcttc aacgtgctgg tgcgcgccga gggcagccgc acccgcgtgt
    23521 ccggggtgat cgacttcggc gacgcggcgg ccgtcccccg ggtcgccgac ctcgccgtgc
    23581 tgctgtccag cgtcatgcgc ggcgcggacc gcccgctgga ggtcgccgcg acgctcaccg
    23641 ccgcctacca cgccgcgtgc ccgctgtcgg aggacgagat cgacctgctg ttcccgctgg
    23701 tcgcgatccg gtcggcggcg gtcgcggcga ccaccgcgcg gctgtcggcg ggccgcgcgc
    23761 acggcgaccc ccggcaccgc cggtccggcg cctccgacct ggcccggctg ctcgccgagg
    23821 tcccggcgga gatgggggcg gcggccgtcc gcacggcgtg cgggctgccc gcccaccccg
    23881 ccaccgcgac ggccgccgcc tggctcgccg agaacaccgc cgcgatcacc ccgccggtcg
    23941 cgggaccgct cgcggtgatc gacctcggcg cgagcggcga ctgctacgac ggcgccgacc
    24001 cccgcgagcc cgacgccctg cgcgccgccg cgcgcgaagc gatcctcgcg ttcgggccgg
    24061 agacgccggt gggccgctac gccgagcccc ggttcattgc gccgcggcgg cgcggcgccg
    24121 acgtcacgct cggcgtcgag gtgttcgccg cctccggcac cgaggtccgc gcgccgctgg
    24181 ccgggcgggt ggaggccacc gccccggcgc tggtgctgct ccacgagccg gtcgagggcg
    24241 tgcgcttccg caccgtccac accggtgtgt ccacgcgcct cgccgccggc gacgacgtcg
    24301 cggcgggcgg cacgctcggc gcggtcgccg ccgagaccgc cgacgggctg ccgccgcgcg
    24361 tgcggctcca ggtcacggcc gtgccggtcg cgtcctggcc ggacgtcccg cacctggcgc
    24421 ccggcgacgg cagcgcgctc tggcgcgagc tgttccccga cccgaccccg ctgctcggcg
    24481 cgcaggacgc ggtcgcggcg ccggtcacag cgtgggtgcc caccgccgac cgcgcgctgc
    24541 cgaagcggca ccaccacctg cccaacaccc acccgaccta cttcacgaac ccgatcgcga
    24601 tggtccgcgc ccgcgactgc cggttctacg acgagcacgg ccgctcctac ctggacgcgc
    24661 tgaacaacgt cacgctggtc gggcacggcc acccgaagct cgtcgaggtc gccgcgcggc
    24721 agctgagcag gctgaacacc aacacccggt tcgtctacga cgtgctgacc gagtacgccg
    24781 agcggctcac cgcgacgctc ccggacggcc tggacgtcgt ctacttcgtc aactccggca
    24841 gcgaggccaa cgacctcgcg ctgcggatgt cgcgctacct caccaagcgc gacgacgtcg
    24901 tgatcatcga cgacgcctac cacggctaca cgacgacggt cgccgacgtg agcccgtcgc
    24961 gctacaagca ctacggcaag cccgacacca cccacccgac gcccgtgccc gaccgctacc
    25021 ggggccgcta cggctacgac gacccggagg cgggcgcgca ctacgcgcag cacgtcatcg
    25081 acaccttcga ccggctcgcc gccgagggcc gcccgcccgc cgcgtacctg ttcgaggcgc
    25141 tgctggcggg cggcggccag gtcgtgctgc cgcccggcta cctcgcgccg atcttcgccg
    25201 ccgcgtcccg gcacggcgcg ctgacgatcg ccgacgaggt ccaggtcggg ttcggacggc
    25261 tcggcgaggc gt
//
