LOCUS       NZ_JAICDG010000002     24536 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinomadura terrae strain OS3-83 contig2, whole genome shotgun
            sequence.
ACCESSION   NZ_JAICDG010000002
VERSION     NZ_JAICDG010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura terrae
  ORGANISM  Actinomadura terrae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 2162430)
  AUTHORS   Lee,S.D., Yang,H.L., Kim,I.S., Choe,H. and Kim,J.S.
  TITLE     Actinomadura terrae sp. nov. and Actinomadura litoris OS3-89,
            isolated from rhizosphere soil of cactus
  JOURNAL   Int J Syst Evol Microbiol 73 (1) (2023)
   PUBMED   36748505
REFERENCE   2  (bases 1 to 2162430)
  AUTHORS   Lee,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2022) Institute of Jeju Microbial Resources, BioPS
            Co., Ltd., Sancheondan Dongil 16, Jeju 63243, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 141x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022751215.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:12:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,085
            CDSs (total)                      :: 8,002
            Genes (coding)                    :: 7,936
            CDSs (with protein)               :: 7,936
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 2, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 13 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 3 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 651401
            Orig. end                         :: 675937
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAICDG010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24536
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24536
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24536
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14536](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14536
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(225..1646)
                     /locus_tag="K2F47_RS13180"
     CDS             complement(225..1646)
                     /GO_function="GO:0004197 - cysteine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012862.5"
                     /locus_tag="K2F47_RS13180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="caspase family protein"
                     /protein_id="WP_242903135.1"
                     /transl_table=11
                     /translation="MAPPTEPRTDLADSRALLIGTSRFHDAEFTGVPAAANSLAGMYEM
                     LTDPARGGWPRDQVTTIADPQGAAWLVQRIRRMTESTTGTFLLYYVGHGVISERGNLTL
                     TLTDTTSSDPDLTGVEFHHVQRALSTSPARVSVVILDCCYSGRAISALSGLDTVADCTS
                     IEGVYTLTAAEGPAHVVPLNQQHTTGTSFTQELLDLIGEGLPDGPELLTFHTLYGRLAH
                     RLHRRGLPRPNQRGTDTVHHFGLARNTAYGRSPRLSNDATEPTSSPTTLDTPSPAAPPV
                     KASPGQYPPVFTSRIRAAKVVTSRLGSLHISFVVLTILCSLLLPVDASPVDLITFGILL
                     GTLLALLIFIMAQFVMTLVELAGPRHLSIRPEGVSIVWGRRRADYSWDEIGALEVANTG
                     GPRPRPTLMLWKKQAPWTPPPHQARRLGHSSRRPPWEDRTSGWIRICYLDQLQDGRELE
                     ELATTGTPWIQSNRP"
     gene            complement(1630..1986)
                     /locus_tag="K2F47_RS13185"
     CDS             complement(1630..1986)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040404.4"
                     /locus_tag="K2F47_RS13185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_242903136.1"
                     /transl_table=11
                     /translation="MDLQIEVTGGDEAGEHARLLEWLRADRRLAGHVRVRRRAPGAEEL
                     GGTLDAVMVAVGSGGVSAVLAQTLPAWIRSRRPKVKFTLTTEDGERLELETADAAEAPR
                     LIAELLRHHHGASD"
     gene            2215..2631
                     /locus_tag="K2F47_RS13190"
     CDS             2215..2631
                     /EC_number="1.20.4.4"
                     /GO_function="GO:0030612 - arsenate reductase (thioredoxin)
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573771.1"
                     /locus_tag="K2F47_RS13190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="arsenate reductase ArsC"
                     /protein_id="WP_242903137.1"
                     /transl_table=11
                     /translation="MASGKPSVLFVCVHNAGRSQMAAAFLAHLAGDAVEVRSAGSAPAG
                     EVNPVVVDAMSEVGIDVSAETPKILTVDAVQASDVCVTMGCGDSCPVFPGKRYLDWPVA
                     DPAGQGIEAVRPVRDEIERRVRGLIEELGVQGLA"
     gene            complement(2714..3289)
                     /locus_tag="K2F47_RS13195"
     CDS             complement(2714..3289)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013989.5"
                     /locus_tag="K2F47_RS13195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_242903138.1"
                     /transl_table=11
                     /translation="MSTIVIAFTTLDGIVTDPDGADGTPTGGWAFRHGPGTADGDKFRL
                     GSTLDDGVLLLGRKTWHSFAQLWPGRDDPFSQRMNAVPKLVASRSLPDTSAWENSRLVD
                     GDLIDAVKRERRDVIVAGSLSIGRALMAADLVEEYRLLVFPTILGTGEHLFPVDGPTTH
                     LACASSEQIGAAVLTRYTRAPLARPLAG"
     gene            complement(3345..4376)
                     /locus_tag="K2F47_RS13200"
     CDS             complement(3345..4376)
                     /EC_number="2.7.7.6"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017579997.1"
                     /locus_tag="K2F47_RS13200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase subunit sigma-70"
                     /protein_id="WP_308198429.1"
                     /transl_table=11
                     /translation="MVAQRAAGPSRPPSPATPPNPRAVRHHRVGDDGRMDFEPYRGELV
                     AHCYRMTGSFHEAEDLVQETMLRAWKARDRYDAARASVRTWLYRIATNVCLTALEGRAR
                     RPLPSGLGAPSDDPGAPLAPALDVPWLQPFPDARFDTDMRADLRIALVAALQVLPPRQR
                     AVLVLRDVLEFRAAEVAAQLETTVPAVNSTLQRARAALTDVGDMDEVAEPDDPDVQEVI
                     QRYARAFEAADVPALVRLLTDDAVMEMPPVPLWYRGSRDYGLFMDRVFEMWGPGWAMRQ
                     LTANGQPALAAYAPAPDGELRMHTLQVFTVVHGRLARNVVFSDPDVFRAFALPERISST
                     ESR"
     gene            4407..4751
                     /locus_tag="K2F47_RS13205"
     CDS             4407..4751
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853521.1"
                     /locus_tag="K2F47_RS13205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_242903140.1"
                     /transl_table=11
                     /translation="MGTASSLDGRRFRAVQDTVGGEVGTETEFTYHEDGGEVWAEYGGG
                     GVRRGFLVGTREGDRLDFRYSQLNSEGGTSSGHCVTAITTLPDGRIRLDETWEWESRPG
                     SGTSAVEELR"
     gene            complement(4843..5163)
                     /locus_tag="K2F47_RS13210"
     CDS             complement(4843..5163)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546015.1"
                     /locus_tag="K2F47_RS13210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_242903141.1"
                     /transl_table=11
                     /translation="METTPSRPNAKPWTFLTNHARVLIHLARDPDARVRDVAQEIGITE
                     RAAQLIINDLEEAGYITRTRIGRRNSYTVNAHQPFRHPTEADHDVEALIELFAGQDAAA
                     LA"
     gene            5447..5776
                     /locus_tag="K2F47_RS13215"
     CDS             5447..5776
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013868.5"
                     /locus_tag="K2F47_RS13215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="STAS domain-containing protein"
                     /protein_id="WP_242903142.1"
                     /transl_table=11
                     /translation="METCHEGRYTVLTLTGSLVADTVVTAEARVLTTIVLAEAPLALVL
                     DLSKLEMVDLHGAHLLSKAQFAVRAARGTLHLIAPPGAPARGALSRYLLGSTVERREDL
                     KLLTG"
     gene            5929..6786
                     /locus_tag="K2F47_RS13220"
     CDS             5929..6786
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012318.5"
                     /locus_tag="K2F47_RS13220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trypsin-like serine protease"
                     /protein_id="WP_242903143.1"
                     /transl_table=11
                     /translation="MKSRPFAGGAAARPLRLAMTALAATLLWFGVSAPSALASPAPPGA
                     STMIIGGSDATEPYSFMVSVQDAGGHFCGGSLITGDWVVTARHCVEGRNPADLQLRIGS
                     LRKDEGGTVRGVERFVTHPESDTATHDIALVRLDQPVADAPVPVDVRQPAGTPARLLGW
                     GCTLPGQVCGEEGRPAVLQQLDSAVREPTACTNQVTPLDPASEVCTGNPETQAGPCFGD
                     SGGPLLRRDGTGWKLIGAFSRVEIKPPDPGQPNEPPNCRSGMGIYTDVPAHREWIDGVI
                     SSTS"
     gene            6876..7250
                     /locus_tag="K2F47_RS13225"
     CDS             6876..7250
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545245.1"
                     /locus_tag="K2F47_RS13225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_242903144.1"
                     /transl_table=11
                     /translation="MEEHAVPILPSRDLDETREFYARLGFETHGSWLDAGYLMVARGDV
                     QLHFWHHPEVDPLTTAGACYVYVEDADALHRAWDEIGVPTEEATGSRLVPPQDTDYGMR
                     EFALVDRSGNLLRVGSSATA"
     misc_feature    7260..7273
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 22.38"
                     /tool="antismash"
     misc_feature    7317..7330
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     gene            7317..7673
                     /locus_tag="K2F47_RS13230"
     CDS             7317..7673
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012851657.1"
                     /locus_tag="K2F47_RS13230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cupin domain-containing protein"
                     /protein_id="WP_242903145.1"
                     /transl_table=11
                     /translation="MLEIKSIDKPDERRDFPKGHLEVLQMTGLVFARATFEPGWRWTES
                     LRDIAGTDLCEVHHNGYIVQGRLRVRMRDGGEQEGGPGDAFVVTPGHDAWVVGDEACVV
                     FDFAGGMDEYAKAD"
     gene            complement(7759..8823)
                     /locus_tag="K2F47_RS13235"
     CDS             complement(7759..8823)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012318.5"
                     /locus_tag="K2F47_RS13235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S1 family peptidase"
                     /protein_id="WP_242903146.1"
                     /transl_table=11
                     /translation="MNRGMRLKRATIPLLSAAALITLPAFGTVQASARTDPVQDVQNRD
                     VQIRQTALADQITGRLGARQAGSYLDGAGNLVVNVTDAAAARQVTAAGARARVVAHGIR
                     QLTGAKARLDRLAGTPGTTGLAWGVDVVSNSVVVDVPRADNDAATRAFVKRARALGEIV
                     RVRRVAAAPRPMVGPGDAIITGGSRCSVSAIAVGGGAEFVVTAGHCTRISADWTTKDGQ
                     TLGTREASRFPGDDYGTIRVTNGSLKNDNAQLTSVGRPAVGSQIQKKGSTTNTTSGTIR
                     GYDRTVNYQEGTVSGLIETTACTQPGDSGGSLQAGTVAVGIVSGGTTGACRANYQSYFQ
                     PLDEALQSQNLTLK"
     misc_feature    complement(8968..8984)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.58"
                     /tool="antismash"
     misc_feature    complement(9035..9049)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.19"
                     /tool="antismash"
     misc_feature    complement(9332..9347)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     gene            9706..9870
                     /locus_tag="K2F47_RS13240"
     CDS             9706..9870
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS13240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242903147.1"
                     /transl_table=11
                     /translation="MPFNENSIAELDELTADELTEILDLDVQIDSVTDAPAPQLCGFTQ
                     ASQLCTFTC"
     misc_feature    9734..9752
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.15"
                     /tool="antismash"
     gene            10001..13180
                     /locus_tag="K2F47_RS13245"
     CDS             10001..13180
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="K2F47_RS13245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_242903148.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.8e-165,
                     bitscore: 547.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4e-33, bitscore:
                     112.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADPPIIAPETLECADFALLRTPAYPRSEADRTLVDIVPGRSDER
                     ALLTGLITRLVADQRLMEAVAFSSPPLFQEARAIASGGGGERKLSTIRRVTYSLSSYLL
                     RMSTRATPFGLLAGATVAHFGSRPKAEYRANDRKHPQVDLAWLRDVLTGLRDDPRVLAG
                     LPVQANKAVRFKGGRIILPYLPPAASDDPADHKTGSLSLRLTPVTAEIVSQAAAEVKST
                     TLVQRVAENLGVQPKIVLAVVRQLIGNEILLTGLQPSLVAADVLGEALGRLEHVPDHPV
                     VRSLRQLHDALVRYADEPDEKRLALLQRMIEQAGELSPAAHKLRVDLEIDADVTLPSIV
                     ATELAEAVRVLCRVMPVYIGVPALRGFHLAFLERYGTDRLVPVKDLLDPDIGLGAPAEY
                     QCPPSSRDDPAFTPDTATRDQVVAEMVADAIRTGAREVELTDELVERLASPESGALPAS
                     LDFYAHLVAPSLEAMSTGDFRLVASPAPGAQRGGTSFGRFLHMLGTQAGPVMEFGREVP
                     LGNGAPLPADLVYHTRFPRALNVVQAPPRFDHRITLGEIDANGPVEEVDLDDLEVGADM
                     KGLFLYSRRRRRRVVPSANHVLNPDRQAANLARFLSDVGYEGTRVWTAWNWGELDRFPF
                     LPRLRYRRTVLYPATWRINDPRITDSSEHFDIWRQALLEWRKNWGVPDRVQLWSIGDHR
                     IVLDLTNAFHLQILRREIGRSSELVVREVLAGEDYPDGWLTGPGGGYVCELVVPMVNTT
                     MKRRERARRTGPLPSQNAAPPRWERALSHLPGSDWLCANIYCSPEAQSALVAGPLKKIC
                     HTVSSRGWADRWFFLRYRDRADHVRLRFHGARETVTGPLLSQFHEWMADLHADGQIGWL
                     SLESYEPEIERYGGVRAMKAAEEYFTADSELAMNFAALLRGRALPLDETLLCAIGIADL
                     VTRFRQSLEQSAPLAQDPEYRRAFTDRRREAVKLIDPVAKWTGLRATPEGEHVVALLRA
                     RSSALCCYATTIRELTAAGQCSNSPEKILDSLVHMFCNRVMGIGQDRERRAVAVALGAL
                     QANLDKRRFMG"
     gene            13220..14536
                     /locus_tag="K2F47_RS13250"
     CDS             13220..14536
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="K2F47_RS13250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_242903149.1"
                     /sec_met_domain="LANC_like (E-value: 5.4e-51, bitscore:
                     170.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLETAKRLRDPRSVATIMQRAANADPLTAASLWEPCTLSRGFPGT
                     AVLFGWLSRIDDRWRKVAHEHLEASVGALRAAPSLGLYYGTGAVAFAARTAAVQPGDYA
                     TLVQRLEAAVARDVLRRLTAMDERGPSLATTSPWQGYDVITGMAGVGRLLLEGAVRQDH
                     DHLLAVTQICHYLVGLTRNVAVEGHQVPGWWVPHAPGVTPGDGHFSPGMAHGVAGPLAF
                     LALALKRGIEVAGHREAVDRVASWLCARRIIHQGRTSWPLRLSLTEELSGAVNEATATR
                     AAWCYGTAGTALALYWAGRALGRGDFTDIAVQALLAALRSSPKTWNLEGVSLCHGLAGL
                     LVISLRISLEADREELRNAVGELLPRLLDSFDEEAPFGYRHQMAGVNQPWSVDRPTADV
                     NICGVLEGAAGVALTLLGWVMPSMLKDEPLPWDAVLLAG"
     misc_feature    13457..13459
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14582..15145
                     /locus_tag="K2F47_RS13255"
     CDS             14582..15145
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014494.5"
                     /locus_tag="K2F47_RS13255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavoprotein"
                     /protein_id="WP_242903150.1"
                     /sec_met_domain="Flavoprotein (E-value: 1.3e-21, bitscore:
                     73.7, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIGITGSIGLLAMPMYLNAFRLFVAREIDLIVTRSAERMIPRST
                     WAILGNSVTCESDPPAPEHVSLPAGADLFLVAPATANVLGAAAHGLGPSVLTSAVLASP
                     GPVVFVPNMNRVMWEKPAVQRNIRVLREDGHQVVEPNHGFAFEVATRRFERHYTLPAPE
                     ELTSTLRAIIAERGDGSRRNAHMG"
     gene            15169..15669
                     /locus_tag="K2F47_RS13260"
     CDS             15169..15669
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016060.5"
                     /locus_tag="K2F47_RS13260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GtrA family protein"
                     /protein_id="WP_242903151.1"
                     /transl_table=11
                     /translation="MTIANAVLEKMPEQVRPILIKRRVLLKFGITGGLCYVVTTIIYYA
                     LKLTLLENKPVTALLVATAVATVLSYILQRQWAFRVTGSRRRFGEFLLFVLINAISMGI
                     NAIPLYAARYWFGLEQPHVSQQVQEVSDFLSGMILGTLLAMLFRWWAYRRFVFGGRVLA
                     QGA"
     misc_feature    15316..15318
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15748..16833
                     /locus_tag="K2F47_RS13265"
     CDS             15748..16833
                     /EC_number="3.5.4.4"
                     /GO_function="GO:0004000 - adenosine deaminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009168 - purine ribonucleoside
                     monophosphate biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618842.1"
                     /locus_tag="K2F47_RS13265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenosine deaminase"
                     /protein_id="WP_242903152.1"
                     /transl_table=11
                     /translation="MSDRPTLDEIRRAPKVLLHDHLDGGVRPATIVDLARESGYGALPT
                     DDAENLRLWFEEAADSGSLERYLETFDHTVGVMQSAEALTRVAYECAEDLAKDGIVYAE
                     VRYAPEQHVTGGLTLEQVVEAVLEGFARGRRDHGIRVGALVTAMRHQARSKEIAELAVR
                     YRDAGVVGFDIAGAEAGYPPTRHLDAFEYLQRENAHFTIHAGEGFGLPSIWQAIQWCGA
                     DRLGHGVRIIDDIDVDGGEPKLGRLADYVRDKRIPLELCPTSNIQTGAARSIAEHPIGL
                     LRRLSFRVTVNTDNRLMSGTSLSEEFAKLSEAFGYGWDDLQWFTVNAMKSAFAPFTERL
                     ELINGVIKPGFAQLKWSRPPA"
     gene            complement(16834..17883)
                     /locus_tag="K2F47_RS13270"
     CDS             complement(16834..17883)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040015.4"
                     /locus_tag="K2F47_RS13270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6177 family protein"
                     /protein_id="WP_242903153.1"
                     /transl_table=11
                     /translation="MTTTNTHAALDIVTTRSAVAIQDRPLVPLSSWLTDAIEKCASVDQ
                     AFQVLTPHDARITFPLRMMLGTPQARWVVQEPGDGYYDGFTGFPLEWDGAAFVASEKAK
                     EGPSATFLQEVPSDGLGHHLIVSLSVVHDAASGLLLGSVIEDLGRALAGAAPRCWGTAE
                     PALSRWSPPDLTALCRRRSPASTLLVFMGPHGGDVPPFGGTVQVSRVTSGVKEVIAFAL
                     ACPADREPPLAELEKLADQYARTGILKTLNAQWTPALPDLTYPSRALGVPTPLAMGVGP
                     EGVAEIGIEHALSAETPGRRIGDAASPGLWFPLDGDGSGDGIGAWARYRALMEHLTTPV
                     PGTGRWQTS"
     gene            complement(17880..18254)
                     /locus_tag="K2F47_RS13275"
     CDS             complement(17880..18254)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS13275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242903154.1"
                     /transl_table=11
                     /translation="MTYDMVVLTQRAPDVRAIVDSMVAAGETLRVRGGGDGALILLRDD
                     AGSPLVSIESAQRVDVEGEVGRVLGGPVDAGLTVPYWWVEVRASGGDPRAPGIAHRFAD
                     AMVERLGGAVWPSNAPEETR"
     gene            complement(18251..22246)
                     /gene="eccCa"
                     /locus_tag="K2F47_RS13280"
     CDS             complement(18251..22246)
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="eccCa"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013155618.1"
                     /locus_tag="K2F47_RS13280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type VII secretion protein EccCa"
                     /protein_id="WP_242903155.1"
                     /transl_table=11
                     /translation="MTTRLVHRPARTVYPRTDAEPRQVEAPPTLPEAGGTGNQLMTILP
                     MVGMMGSLTIMTVMRNPAFMAFGAVLLVVAVLGGGALLLSRKGQVTRQRKNQRERYLEF
                     LEELREELSAEERAHRTLARVLDPPPEALYDVVRDPSRLWERRRTHEDFLRVRVGTGLM
                     PGHSLELGEQGTALNPTDPFMSSEARAVLERFRTAPDMPLTLPLDMAGDVSVIGSRPDV
                     LRLVRAMVVQLVAFHAPEDVAIGAAYGGGSADWDWLKWLPHVHDQHRRDGGVPIRLIAS
                     SPLKLAALLADELRRRSDYAAEVRRGLNRRDSFRMLRRLVVFQDTHGEVAAELVRPDES
                     VPVADLAATVVHLLADRTHEPGDVGVRITVEGDRVRVEDLRGPEPVEMSGTVDDVPAAM
                     LEGLVRMVAPLRLSRESVDETAGQGGEVDFAGLLGVPDPGDLDVARLWAPRGERAFLRV
                     PVGLDDAGRPVILDLKEAASLGMGPHGLCVGATGSGKSELLRTLVLALAATHGPEQASM
                     VLVDYKGGATFAPFDGLPHVAGVITNLEDDAGLIERVYASLSGEVQRRQQVLRDAGNIA
                     NIGDYNHLRGQRPDLPPLPHLLVIIDEFGELLTARPDFIELFLSIGRIGRSIGVHLLLS
                     SQRIESGKLRGLETYLSYRIGLRTFSEEESRTVLDSPDAFHLPALPGFGYLKVDTSIYL
                     RFKGGYVSGPYRGAVAAPAEGADRLPVRPFTAYNLAGPLDGPVRNAPDDEAELPERTTG
                     PTMLDVLVGQLARHGRPVQMIWLPPLPAMTTLDAVTGPVRITEQGMRLPAQAGPLRVPI
                     GLLDDARRQWQGVWNLDLTAAGGHVAIIGGPQTGKTTLLRTFVLSLALTHTPRQVAVYG
                     LDLVGGGLQVLSGLPNVGGVAGRTDLERIRRTVEEVHGMLEHRMEVFRQHGIDGIQRLR
                     QMHAAGSVPELSCADVVLVVDGFGAIRGDFEEIDDMVSDLLQRGGGYGIHIVAGMLRWN
                     DVRIAAQSTFGQRVELRLNDPSDSTVARKLAETISAELPGRALTDAGLFGHVAVPALGA
                     VPDPTELGTAAEAAVGAVRNAWTGESTPPVRVLPHRLPVSELPDPEREPRLVPLGVEER
                     ALEPLLLDLFDVDQNLVVLGDGGSGKTNLMRLIVQQLVARYTPEQVVFAVMDPRRSLRD
                     VAPEAYVGGYAPTPRICAGLAGGVAKELKERMPEDPSAVPDGAGVKGPRIVVLADDYDL
                     LTTAGQQPLAPFVPFVPSGRDIGLHFVVARRVAGSSRGLYDPLLQAVRESGTGALVMSG
                     DRSEGQLFPRVYAESLPPGRAQWIRRGESARLVQTALAEAPVREEAR"
     gene            22345..23226
                     /locus_tag="K2F47_RS13285"
     CDS             22345..23226
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630098.1"
                     /locus_tag="K2F47_RS13285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_242903156.1"
                     /transl_table=11
                     /translation="MDELFEVSADVHALIQDLLPVINPSARFQPELAQVVLPVGRFEPS
                     ATTWTILERCARADRVAWPRLVEEWLVHVSDRAALAIGDIELLGDVRKRLRIRMVPKLT
                     ESERQGLATVSAGRHFDAVIMIDHPEYGGPLTLARASLLGLTDLGELAVPNTYQVELAD
                     VDVHDQPLTLTESIRVIHKPGSRYVSALMAELRHFLPDVGKAGALVAVPTHSTILAYPI
                     VSAAMGEVFGPFRELTKEMYAASDDPTSPDVFWWRHDQPLVKLDPEAGAPPELDPSPSP
                     ARKRRSRFGFRR"
     misc_feature    22347..22361
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.44"
                     /tool="antismash"
     gene            complement(23216..24382)
                     /locus_tag="K2F47_RS41345"
     CDS             complement(23216..24382)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013793.5"
                     /locus_tag="K2F47_RS41345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_242903157.1"
                     /transl_table=11
                     /translation="MADQDRDVPPPDPDLTVVDAPKLHRHAPQAQPPPPPPPTSPPPAF
                     GQPSDLSVTRPDQPPPRANPAPPPPPPQASPAPPPRPAPLVVPTAPETLVQGPVHGDSV
                     MRRVLRGALHPFRSADDVREVTEHGRWIAHPVTTGRRIAVMGVREGSGKSTVSALVTTA
                     FARHRDDRVLALDLDPEMGSLPLRLGVRNEHPVADLAGADLSTASFEQVRQFLVPLGER
                     LWALPTTYGTVGAGRGLVDAGRYQSAGVQLSRFFGVTVADNGAGTRTPLHRAVLAAAHA
                     QILVAPATVDGAAAVGRVLDWMGSGDLRALLPRTLVVFTSHTPHKAGTVDVDRAAGILA
                     EVGVNTIRLGFDRQLAVGTTLDHARLAYATRLTAIAIAAEALRLALTV"
ORIGIN
        1 ttgtccatcc gctggatcgc catgggccga gcgtagtgga ccccggtgac gaaacctccg
       61 cgccgcggtc atcgcctgcg tgacagccag gccaccaccg tccccaccag gatgaggatt
      121 attgcggcga cagcggcgat gatgactact aggaactgca tggaaatttc ctttgcgaga
      181 ggccccggaa tcgattctcc gggagggggg tgggcaatgc cgcgtcaggg ccggttcgac
      241 tgaatccatg gcgtccccgt tgtcgccagc tcttccagtt cgcggccgtc ttgcagttgg
      301 tcgagatagc agatgcgaat ccatccggac gtgcggtcct cccatggcgg gcgccgagag
      361 gaatgaccca gtcgtcgtgc ctggtgaggg ggcggggtcc agggggcctg ctttttccac
      421 agcatcaggg tcgggcgggg gcggggccct cccgtattcg ccacttccag tgcgccgatc
      481 tcgtcccagc tatagtccgc tcggcgcctt ccccacacga tggagactcc ttcggggcgg
      541 atgctcaggt gacgaggacc ggccagttcg accaacgtca taacgaactg ggccatgatg
      601 aagatgagaa gtgccagaag ggttccgagc aggatcccga acgtgatcag gtcgaccggt
      661 gaggcgtcca ccgggagaag cagcgagcac aggatcgtga gaaccacgaa ggaaatgtgc
      721 agggagccga gtcgggaggt caccactttg gcggcccgga ttcggctggt gaagaccggt
      781 ggatattgtc caggggacgc tttgaccggc ggagccgctg gggacggggt gtcaagagtt
      841 gtcgggcttg acgtcggctc tgtggcgtcg ttcgaaagcc ggggcgaccg gccgtaggcg
      901 gtgttgcggg ccaggccgaa gtggtggacg gtgtcggtcc cgcgctggtt gggacggggc
      961 agcccgcggc ggtgcaggcg gtgggccagg cggccgtaca gggtgtggaa ggtgaggagt
     1021 tcgggcccgt ccggtaggcc ttcgccgatc aggtccagca attcctgggt gaaggacgtt
     1081 ccggtggtgt gctgctgatt gagcgggacg acatgggccg ggccttccgc ggcggtcagc
     1141 gtgtacacgc cctcgatgct ggtgcagtcg gcgacggtgt ccaggccgct cagagcgctg
     1201 atggcccggc ctgagtagca gcagtcgagg atgacgaccg agacgcgcgc cgggctcgtg
     1261 ctcagcgcgc gttggacgtg gtggaattcg acgccggtca ggtcggggtc ggagctggtg
     1321 gtgtcggtca gcgtgagcgt gaggtttccg cgttcgctga tgacgccgtg gccgacgtag
     1381 tagagcagga aggtcccggt ggtgctctcg gtcatgcgcc ggatgcgctg caccagccac
     1441 gcggcgccct ggggatcggc gatggtggtg acctggtcgc gcggccagcc gccgcgggcc
     1501 gggtcggtga gcatctcgta catgcccgcc agactgttgg cggcggcggg cacgccagtg
     1561 aactccgcgt cgtggaaacg ggaggtgccg atcagaaggg cgcgggagtc ggccagatcg
     1621 gttcgcggct cagtcggagg cgccatggtg atgccgcagc agttccgcga tgagacgtgg
     1681 cgcctcggct gcgtccgccg tctccagttc cagtcgctct ccgtcctcgg tggtgagggt
     1741 gaacttcacc ttcgggcggc ggcttcggat ccaggccgga agggtctggg ccagcacggc
     1801 ggacacgccg ccggacccga ccgcgaccat caccgcgtcc agcgtcccgc ccagttcttc
     1861 tgctcccggc gcccgccgcc ggacgcggac gtgcccggcc agccgccggt cggcgcgcaa
     1921 ccattccagg agccgggcgt gttcaccggc ctcgtcgccg ccggtgacct cgatctgaag
     1981 gtccatttat ctccgacccc gccgccccgc cccgcgctcg tcagccttct tgatacgccg
     2041 ttcgcagcat ctcagggaag gcgggtgcgg tgcagggaat tggccacgga gcgccaagat
     2101 ccggtttctc ggctcgcgag ggccgccggg cttgggcttg gacggctcgt cccgggccgg
     2161 tctatcttgt cctcgcccgc cgaggtcgtt tcgcatgcga aggggtcctt gcccatggcg
     2221 tccggtaagc ccagcgttct tttcgtgtgc gtccacaatg cggggcgctc ccagatggcc
     2281 gccgcgttcc tcgcccattt ggcgggggac gccgtggagg tgcgctcggc ggggtcggcc
     2341 ccggcggggg aggtgaaccc ggtcgtcgtg gacgcgatgt ccgaggtcgg catcgacgtt
     2401 tccgccgaaa ctcccaagat cctcacggtg gacgccgttc aggccagcga cgtgtgcgtc
     2461 accatgggct gcggcgactc ctgccccgtc ttccctggta agcgctacct cgattggccc
     2521 gtggccgacc ccgcggggca ggggatcgag gctgttcggc ccgttcggga cgagatcgag
     2581 aggcgcgtcc ggggcctgat cgaggaactc ggcgttcagg ggctcgcgtg aaccggcgac
     2641 gaccgggagg tcggtggggc ggaccggcgg cgattccggt ccgtcgcacc gcgtccaggc
     2701 gttgttccag cggtcacccg gccagcggac gagcgagtgg tgccctcgtg tagcgcgtga
     2761 ggacggcggc gccgatctgt tccgacgacg cgcacgcgag gtgcgtggtc gggccgtcga
     2821 cggggaagag gtgctcgccg gtgccgagga tcgttgggaa gaccagcagc cggtactcct
     2881 cgaccaggtc cgcggccatc agtgcccgcc cgatgctcag gctgccggcg acgatcacgt
     2941 cgcgccgctc gcgcttcacg gcgtcgatga ggtcaccgtc gacgagtcgc gagttctccc
     3001 aggccgacgt gtcgggcagc gagcgggagg cgacgagttt cgggacggcg ttcatgcgtt
     3061 gggagaacgg gtcgtcgcgt cccggccaga gctgcgcgaa cgagtgccag gtcttgcgtc
     3121 ccagcagcag gaccccgtcg tccagcgtgc ttccgaggcg gaacttgtcg ccgtccgccg
     3181 tgcccgggcc gtgccggaac gcccagccgc cggtcggtgt cccgtcggcg ccgtccgggt
     3241 cggtgacgat tccgtccagg gtggtgaacg cgatgacgat ggtgctcacg atggtgtccc
     3301 tccggttgat gctcgcccgt acataccggt ggcgtcggcc ggactcatcg cgactcggtg
     3361 gaagaaatcc tctcgggcag ggcgaacgcc cggaacacgt ccggatcgga gaacacgacg
     3421 ttgcgcgcga gccggccgtg gacgactgtg aagacctgca aggtgtgcat gcgaagttcg
     3481 ccgtcgggtg ccggcgcgta tgcggcgagc gctggttggc cgttggcggt cagttgccgc
     3541 atggcccagc cggggcccca catctcgaac acgcggtcca tgaacaggcc gtagtcgcgg
     3601 ctgccccggt accagagcgg caccggcggc atctccatga cggcgtcgtc ggtgaggagc
     3661 cgcacgagcg ccgggacgtc ggccgcctcg aacgcgcgcg cgtaccgctg aatcacctct
     3721 tggacgtcgg gatcgtccgg ctcggcgacc tcgtccatgt cccccacgtc cgtgagcgcg
     3781 gcgcgggccc gttggagcgt gctgttgacg gccgggaccg tggtctccaa ctgcgcggcg
     3841 acctccgccg cgcgaaattc caggacgtcg cgcaggacga gcacggcccg ctggcgtggg
     3901 gggagtacct ggagcgccgc caccagcgcg atccgcaggt cggcccgcat gtccgtgtcg
     3961 aaccgcgcgt cggggaacgg ctggagccag gggacgtcga gcgccggtgc gagcggcgcc
     4021 ccggggtcgt cgctcggggc tccgagcccg gacggcaggg gacgccgcgc gcgtccctcc
     4081 agcgcggtca aacacacatt ggtggcgatc cggtacaacc aggtgcggac ggaggcgcgc
     4141 gcggcgtcgt agcggtcgcg ggccttccac gcacgcagca tggtctcctg gacgaggtcc
     4201 tccgcttcgt gaaaggagcc cgtcatccga tagcagtgcg ccaccaactc gccccggtag
     4261 ggctcgaagt ccattcgccc atcatcgcct acccgatggt gccggacggc gcgagggttc
     4321 ggcggcgtcg caggtgaggg cggtcggctc ggccccgccg cgcgctgggc gacgatgccg
     4381 cgggcccggc gggtaccgtg atgatcatgg gaactgcttc ctcactggac gggcggcgct
     4441 tccgggccgt ccaggacacc gtcggcggcg aggtcggcac cgagaccgag ttcacctacc
     4501 acgaggacgg cggcgaggtc tgggccgagt acggcggcgg tggcgtccgg cggggattcc
     4561 tggtcgggac ccgcgaaggc gaccggctcg acttccgcta cagccagctc aactccgagg
     4621 gcgggacgtc cagcggccac tgcgtcacgg cgatcaccac cctgccggac gggcggatcc
     4681 gcctcgacga gacctgggag tgggagtcgc gccccggctc gggcaccagc gccgtcgagg
     4741 aactgcgctg acccgccgcg ccgagtaggc acaccggagc accccgacgc gccaaatgcc
     4801 gcggacgccc tcgccgggcg agggcgtcct gcgtgggccc tctcaggcga gggcggcggc
     4861 gtcctgtccg gcgaacagtt cgatcagtgc ctccacgtcg tggtcggcct cggtcgggtg
     4921 ccggaagggt tgatgcgcgt tgacggtgta gctgttgcgg cgtccgatcc gggtgcgggt
     4981 gatgtacccc gcctcctcca ggtcgttgat gatgagttga gccgcgcgtt cggtgatccc
     5041 gatctcctgt gccacgtccc gtacgcgtgc gtcgggatcg cgggccagat ggatcagcac
     5101 ccgtgcatgg ttggtcagga acgtccatgg cttggcgttc ggccgactcg gcgtcgtctc
     5161 catccgttca cccctcgtcc agtacgcatc cttgcacccc gagggggcag cgggggatgc
     5221 tccccgacgg gcgcgaggtg tgggtcacag acatcatacg agattgattt gacgaataat
     5281 atttcaggta ttaactttgc cctgttcgtc gttgtcctgt gtctgtgacc gctaggagag
     5341 ttccgtgctg gtgcgatcca acgagccgca gctcgcgagt tccggcccgc ccccgacagg
     5401 ggcgtcgccg gacggccccg ctcgtcccgg acgaggggag ttgaggatgg agacctgcca
     5461 cgagggccgg tacaccgtcc ttacgctgac gggaagcctg gtggcggaca cggtggtgac
     5521 cgccgaggcc cgcgtcctga cgacgatcgt cctcgcggag gcgccgctgg ccctcgtgct
     5581 ggacctctcc aagctggaga tggtcgacct ccacggcgcc cacctgctga gcaaggccca
     5641 gttcgcggtc cgcgccgcgc gcgggactct gcacctgatc gcgccgcccg gagccccggc
     5701 ccgcggcgcg ctgagccggt acctgctcgg gtccacggtg gagcggcgag aggatctcaa
     5761 gctgctgacc ggctgagacg cgcccctggt acaggctgct gtaccgcgat tcggcccgct
     5821 ggccggatcg ccgcgcggag tccgggtccc tagcgtcggg acgaacgatc atctcgtcgc
     5881 gcgggggccg ggcgagtcct tcccggcctc cgcctcccag gaggacccgt gaagtccaga
     5941 cccttcgccg gaggggcggc agcccgtccc ctccggctgg ccatgaccgc gctcgccgcg
     6001 accctgctgt ggttcggcgt atcggcaccg tccgcgctcg cctcgccggc tccgcccggc
     6061 gcgtccacca tgatcattgg cggttcggac gccaccgagc cctactcgtt catggtctcc
     6121 gtccaggacg cgggcgggca cttctgcggg ggcagcctga tcaccggcga ctgggtggtc
     6181 acggcccggc actgcgtcga gggcaggaat cccgcggatc tacagctgcg catcgggagc
     6241 cttcgcaagg acgagggcgg gacggtccgc ggggtcgagc gcttcgtcac ccaccccgag
     6301 agcgacaccg cgacccacga catcgcgctc gtcaggctcg accagccggt cgcggacgcg
     6361 ccggttccgg tggacgtccg gcagcccgca ggcaccccgg cccggctgct gggatgggga
     6421 tgcaccctcc ccggccaggt ctgcggcgag gagggcaggc cggcggtgct ccagcagctc
     6481 gactcggccg tccgcgagcc gaccgcctgc acgaaccagg tgacgcccct cgacccggcc
     6541 tccgaggtct gcaccggcaa ccccgagacc caggcgggcc cctgcttcgg tgactccggc
     6601 ggaccgctgc tgcgccggga cggcaccggc tggaagctca tcggcgcgtt cagccgcgtc
     6661 gagatcaagc ccccggaccc gggccagccc aacgagcccc cgaactgccg cagcggaatg
     6721 ggcatctaca ccgacgtccc cgcccaccgg gaatggatcg acggcgtcat ttcgtcgacg
     6781 tcctgaaaca cccacgcccc ggcgcggcga ccgaccccgc gccggggcgt tcgcgtgccg
     6841 ggagcgctgt cggaggcacg gcatagcgtt gcggtatgga agaacacgcg gtgcccatcc
     6901 tgcccagccg ggacctggac gagacgcggg agttctacgc gcggctggga ttcgagacgc
     6961 acggatcgtg gctggacgcc ggttacctca tggtggcgcg cggggacgtg cagctgcatt
     7021 tctggcacca ccccgaggtc gatccgctga ccaccgccgg cgcctgttat gtgtacgtcg
     7081 aggacgcgga cgcccttcat cgcgcgtggg acgagatcgg cgtccccacc gaggaggcca
     7141 ccggcagccg gctcgtcccg ccgcaggaca ccgactacgg catgcgcgag ttcgcgctcg
     7201 tggaccgcag cggcaacctg ctgcgcgtcg gcagctccgc gaccgcttga tgggacgtgt
     7261 tgacgcaggt caaccctggt gcgagcgtgg aaggtgatgg tgaaaggggg accatcatgt
     7321 tggagatcaa gagcatcgac aagcccgacg agcggcgcga cttcccgaag gggcatctgg
     7381 aggtcctcca gatgaccggc ctggtgttcg cccgcgcgac gttcgagccc ggctggcgct
     7441 ggacggagtc gctccgggac atcgcgggca ccgacctgtg cgaggtgcac cacaacgggt
     7501 acatcgtcca gggccgattg cgcgtccgca tgcgggacgg cggcgaacag gagggcggcc
     7561 ccggcgacgc gttcgtggtc acgcccgggc acgacgcctg ggtcgtcggc gacgaggcgt
     7621 gcgtcgtgtt cgacttcgcc gggggcatgg acgagtacgc gaaggccgac tgagcgcgcc
     7681 ggggccctga acgccggggc cctgaacgcc gtggcctgag cgcggggctc ccgggcctcc
     7741 gggagccccg cgtccggcct acttgagcgt gaggttctgc gactggagcg cctcgtccag
     7801 cggctggaag tacgactggt agttggcgcg gcaggcaccg gtggtgccgc cggagacgat
     7861 gccgacggcg accgtgccgg cctgcaacga gccgccgctg tcgcccggct gggtgcaggc
     7921 ggtggtctcg atcaggcccg agaccgtgcc ctcctggtag ttgaccgtgc ggtcatagcc
     7981 gcggatcgtc ccggacgtcg tattggtggt cgagcccttc ttctggatct gggagccgac
     8041 cgccgggcgc ccgaccgagg tgagctgggc gttgtcgttc ttgagcgacc cgttggtcac
     8101 ccggatcgtc ccgtagtcgt cgcccgggaa tctgctggcc tcccgggtgc cgagggtctg
     8161 gccgtccttg gtcgtccagt ccgcgctgat ccgcgtgcag tgcccggcgg tgacgacgaa
     8221 ctccgcgccg ccgccgacgg cgatcgccga caccgagcag cgcgagccgc cggtgatgat
     8281 cgcgtcgccg ggcccgacca tcggacgcgg cgccgccgcc acccggcgga cccggacgat
     8341 ctcgcccagc gcccgcgcgc gtttcacgaa cgccctggtc gcggcgtcgt tgtcggcgcg
     8401 gggcacatcg acgacgacgc tgttggagac gacgtcgacg ccccaggcca gcccggtcgt
     8461 ccccggggtg cccgcgagcc ggtcgagcct ggccttggcg ccggtcagct gccggatgcc
     8521 gtgggcgacg acgcgcgccc gcgctccggc tgccgtgacc tgccgcgcgg cggccgcgtc
     8581 ggtgacgttg acgacgaggt tgcccgcgcc gtcgaggtag gagcccgcct gccgggcgcc
     8641 gagccgtccg gtgatctggt cggcgagcgc ggtctgccgg atctggacgt cccggttctg
     8701 gacgtcctgg acgggatccg tccgggccga tgcctgaacg gtcccgaacg ccgggagcgt
     8761 gatcaacgcc gcggcactca gcagggggat cgtcgcgcgt ttgaggcgca ttccacggtt
     8821 cacgttcgtc cacctttcgc cgccggtggg gccgctagca ctccggcggc agttcggggg
     8881 ttgcgggggg cgtccgggtc acgggaactc tccggcacga gcctcatgac cggccgtctg
     8941 tgacaggaag gtacttcgcg aagctgtcgg taaccagatt ccagccgcaa ctgaaatttc
     9001 agcccgccct gaatatcagt caaccgccgc aagatcacaa cgacttccat cgaaaagcga
     9061 tcgggctgcc gtgctcgtcg gttggcctcg tgcggtgtac aaggcggtag ttcctgctcc
     9121 tgatgttcgc cgtaaaaatc gatgcgccga agccacgacg ctctgttcaa acgcggcccc
     9181 tgtctcgggc gcctacgttc cccttgatat cggtctttgt tgcgattcgg gtgccggcgg
     9241 agattgggtc aggccgctgc tgtgccaggc gaggtgtttt atcgacaacg acttcgagtg
     9301 acttttcgcg ttcctcaagt tcgggtgacg ttgtggtgta gatcacaact tcttggaatc
     9361 tggcttcgac gtgctgctcg tcgccgaagg cggctgaacg tcgattgtag ggaaagtgtg
     9421 cggaagagtg accatgatcg cggaggtcat gtttgcggaa cgaatcaacc gttcatcgcc
     9481 agtcaagtag ggttcggctc gtggcgggca tctctgcgtg ccataaaatc gctcctaagc
     9541 ggccctcaag ctggggtcat tacatatggt aaaaacgtga ttggagcaca tccacgatgc
     9601 ggtgcggctg gcaaagcggt gttgaccggg tttcgtgctt atcgttaacc tatagttgct
     9661 tcgcggggca attcggtcat gacatcccac agaggagaca ctgccgtgcc tttcaacgag
     9721 aactcgatcg ctgagctgga tgaactcacc gccgacgaac tcaccgagat tctggacctc
     9781 gacgttcaga tcgactcggt caccgatgcc cccgccccgc agctgtgcgg cttcacccag
     9841 gcctctcagc tctgcacctt cacctgctga gggccttagc cggctgaggt gaacccagcg
     9901 gaggtcctcg gtgcgcggtc tgtgcccagc accggggacc tccgcttccg ggccgttgac
     9961 aaggtcgcag cggaatgggc cttgggaagg aagtgcgcag gtggctgatc cgccgatcat
    10021 tgcgccggaa accctcgaat gcgcggactt cgcgcttctt cggacccccg cgtatccgcg
    10081 ttcggaagcc gaccggaccc tggtggacat tgtcccgggc cgctccgacg agcgcgccct
    10141 cttgaccggg ctgatcaccc ggctggtcgc cgaccagcga ctgatggagg ccgtcgcctt
    10201 ctcaagtccc ccactgtttc aagaagcacg ggccatcgcg agcggtggag gcggcgagcg
    10261 caaactctcg acgatacggc gtgtcactta ctcgctttcc agctatctgc tgaggatgtc
    10321 gacccgggcg actcccttcg ggctgctggc gggcgcgacg gtcgctcact tcggttcgag
    10381 gcccaaggcc gagtatcgcg cgaacgaccg aaagcatccg caggtcgacc tcgcgtggct
    10441 gcgagacgtc ctgaccgggc tgcgcgacga tcctcgggtt ctggccggcc tgccggtcca
    10501 ggcgaacaaa gcggtccggt tcaagggcgg gcggatcatc ctgccctacc tgcctccggc
    10561 ggccagtgac gatcccgccg accacaagac cggaagcctg tcgctcaggc tgacaccggt
    10621 caccgccgaa atcgtttcgc aggcggcggc agaggtgaag tcgaccaccc tggtgcagcg
    10681 tgtcgctgag aacctgggtg tgcagccgaa gatcgtgctt gcggtggttc ggcagctcat
    10741 cggcaacgag atcctgctga ccgggctcca gccgtcactg gtggcggccg atgtgctcgg
    10801 cgaggccctg gggcggctcg aacacgtccc agatcatccg gtcgtacggt cgctgcgcca
    10861 gctgcatgac gccctggtgc gctatgccga cgaaccggac gagaagagac tggcgctgct
    10921 tcagcggatg atcgagcagg ctggtgagct gtccccggcc gcgcacaagc tacgggtcga
    10981 cctcgagatc gatgcggatg tcaccctgcc ctccatagtc gccaccgagt tggcggaggc
    11041 cgtccgcgtc ctgtgccggg tcatgcccgt gtacatcgga gtgccggctc tgcgcggatt
    11101 tcacctggcg ttcctggagc gctacggcac cgaccggctg gtcccggtca aggacctgct
    11161 cgaccccgac atcgggctcg gtgcccccgc ggaataccag tgcccgccca gctcgcgcga
    11221 tgatcccgcc ttcacgcccg acacggccac gcgggaccag gtggtcgccg aaatggtcgc
    11281 ggatgcgatc cggacgggtg cgcgcgaggt ggagttgacg gatgaactgg tcgaaaggct
    11341 ggccagtccg gaatctggtg ccctgcccgc ctctctcgac ttctacgctc atctggtcgc
    11401 gccctcgttg gaggcaatga gcaccgggga ctttcggctg gtggcgagcc ccgcaccagg
    11461 cgcacaacgg ggtgggacgt cttttggccg gttcctgcac atgctcggga cgcaggcggg
    11521 cccggtgatg gagttcggcc gcgaggtgcc gctcgggaac ggggcgccgc ttccggcgga
    11581 cctcgtctac cacacacgct ttccgcgtgc tctcaacgtg gtgcaggcac cccccaggtt
    11641 cgaccatcgg atcacgctcg gggaaatcga cgccaacggt ccagtggagg aggtggatct
    11701 agatgacttg gaagtcggcg ccgacatgaa aggcctgttc ctgtactcga ggaggaggcg
    11761 gcgccgggtc gttccctcgg ccaaccatgt cctcaacccc gatcgccagg ccgccaacct
    11821 cgccaggttc ctgtccgatg tcggttacga gggaacccgc gtatggacgg catggaactg
    11881 gggagagttg gaccgctttc ccttccttcc ccggcttcgg tatcggcgca ccgtgctcta
    11941 tccagccacc tggcggataa atgacccgag gatcaccgat tccagcgagc atttcgacat
    12001 ttggcggcag gcgctcctcg aatggcgcaa gaactggggg gtgcccgacc gggttcagct
    12061 ctggtccatc ggcgaccacc ggatcgtcct tgacctgacc aatgcatttc acctgcagat
    12121 cctgcggcgc gagatcggtc gaagctccga actggtggta cgtgaggttc tcgcgggtga
    12181 ggactatccc gacggctggc tcaccggacc cggcggcggc tatgtctgcg agcttgtcgt
    12241 gccgatggta aatacaacga tgaagcgtcg cgagcgtgcg cgcaggacag gccctttgcc
    12301 atctcagaac gccgcgccgc cacgctggga gcgtgcgctg agtcacctgc ccgggtccga
    12361 ctggctctgc gcgaacatat attgctcacc cgaggcacaa agcgctctgg tggccgggcc
    12421 gctgaagaag atatgccaca cggtgtcgag tcgcggttgg gctgatcgtt ggttctttct
    12481 gcggtaccgg gaccgggcgg accatgtgcg actacggttt cacggggctc gtgaaacagt
    12541 gaccggaccg ctgctttcac agtttcacga gtggatggcc gacctgcatg ccgacggtca
    12601 gatcgggtgg ctctcgttgg agtcgtacga acctgagatc gagcggtacg gcggggttcg
    12661 tgcgatgaag gcggccgaag agtacttcac agccgacagc gagctcgcga tgaatttcgc
    12721 cgcgcttttg cgcggccgtg ccctgcctct cgatgagaca ctgttgtgtg ccatcggaat
    12781 cgcggatctg gtcacccggt tccggcagtc cctcgaacag tcggccccac tcgcccagga
    12841 ccccgagtac cgccgtgctt tcactgaccg gcgcagagag gcggtgaagc tgatcgatcc
    12901 ggtcgcgaag tggacggggc ttcgagcgac tccggagggc gagcatgtgg tcgcgctttt
    12961 gcgggcgcgg tcttcggcac tgtgctgcta cgcgaccacg atcagggagt tgaccgccgc
    13021 cggccagtgc agtaactcgc ctgagaagat cctggacagc ctcgtccaca tgttctgcaa
    13081 tcgcgtcatg gggatcggcc aggaccgtga gcggcgcgcg gtcgccgtgg cgttgggagc
    13141 gctccaggcc aacctcgaca agcgccgctt catgggctga gacatgtcga gcccatctga
    13201 gagtgccata tacgaagtcg tgctggaaac ggcaaagcgg cttcgagacc cgcgttctgt
    13261 cgccaccatc atgcagcgcg cggccaatgc ggaccctctg acggccgcct cactgtggga
    13321 gccgtgcacc ctctcgcgcg gttttcctgg taccgctgtc ctgttcggct ggctgtccag
    13381 aatcgacgac cgatggagaa aggtcgccca tgagcacttg gaggcctccg tgggggcgct
    13441 gcgcgcggcc ccgtccttag ggctttacta cggaaccggc gcagtggcat tcgcggcacg
    13501 gacggccgcg gtgcagccgg gggactacgc gaccctcgtg cagcggctgg aggccgcagt
    13561 cgcccgtgac gttcttcggc gactcacagc gatggacgag aggggtccct cgcttgccac
    13621 tacgagccca tggcagggtt acgacgtcat taccggaatg gcaggggtcg ggcgccttct
    13681 cctggaaggg gctgttcggc aagaccatga tcaccttctc gctgtgacgc aaatctgcca
    13741 ttacctggtc ggcctgacgc gaaacgtggc ggtggagggg catcaggtac ccggatggtg
    13801 ggtgccgcac gcgccggggg tgacacctgg cgacggccac ttcagtcccg gcatggccca
    13861 tggtgtggcg ggtccgctgg cgttcctggc tctcgcgctc aagcgtggca tcgaggtggc
    13921 gggccaccgg gaggccgttg accgggtggc ctcatggttg tgcgctcggc gcatcattca
    13981 ccagggtcga acctcttggc cgctgcggct gagcctgacc gaggagctgt ccggcgcggt
    14041 caacgaggcc actgccaccc gcgctgcctg gtgctacgga accgccggca ccgcgctcgc
    14101 tctctattgg gccggtcgcg cgcttggacg gggcgatttc acggatatcg cggtgcaggc
    14161 actactggcc gctctccgga gctctccaaa gacgtggaat cttgagggcg tgtcgctctg
    14221 tcatgggctg gccggacttc ttgtgatctc gttgagaatc tccttggagg ccgaccgcga
    14281 ggagcttcgg aacgcggtgg gcgagctcct gccgaggctg ctcgacagtt ttgacgagga
    14341 ggcgccgttc ggttatcggc atcagatggc cggcgtgaac cagccctggt cggtggatcg
    14401 gccgactgcg gatgtgaaca tctgcggtgt tctcgaaggg gccgcgggcg tcgcgctcac
    14461 gttgctcggc tgggtgatgc cgtcgatgtt gaaagacgag ccccttccct gggacgccgt
    14521 attgctagcc ggataggagg catgagtcat cgcaccggaa cccgagcccg tcgtcgacag
    14581 gatgctgatc ggtattaccg gatccatcgg actcctggcc atgccgatgt accttaacgc
    14641 ttttcgcctg ttcgtcgccc gtgagatcga tttgatcgtc acccgcagtg ccgagcgaat
    14701 gattcctcgt tccacgtggg cgatactcgg caacagcgtc acctgtgaga gcgacccgcc
    14761 ggctccagag cacgtgtcac tgccggcggg agcggacctg ttcctcgtcg cccctgccac
    14821 ggccaacgtg ctcggcgcgg cggcgcacgg gctggggccg tccgtgctga ccagcgccgt
    14881 cctggccagc cctggtccgg tggtcttcgt gcccaacatg aaccgtgtga tgtgggagaa
    14941 gcccgcggtg cagcggaaca tccgcgtcct gcgtgaggac gggcaccagg tggtcgaacc
    15001 gaatcacggg ttcgcgttcg aggtcgcgac ccggcgattc gagcggcact acacccttcc
    15061 cgctcccgag gagttgacca gcacgttgcg tgcgatcatc gcggagcggg gcgatggatc
    15121 tcggcgaaat gcccacatgg gctgaacgat cccgtatagc attgcggcat gacgatcgcc
    15181 aacgccgtgc tggagaagat gcccgaacaa gtgcggccaa ttctgataaa acggcgggta
    15241 ttgcttaagt ttggcataac cggcggactt tgttatgttg tcacgaccat tatttactat
    15301 gctctcaagc tcacgttact ggagaacaag ccggtgacgg ccctcttggt cgccaccgcc
    15361 gtcgccaccg tactgtccta tattttgcag cggcagtggg cgtttcgagt gaccggctct
    15421 cggcgccgtt tcggtgaatt tctgttgttc gtcctgatca atgccatctc aatggggatc
    15481 aatgcgatac cgctctatgc ggcgcggtac tggttcggct tggagcagcc ccatgtgagt
    15541 cagcaggtgc aggaggtctc ggacttcctg agtggaatga ttctcggcac gctgttggcg
    15601 atgctgtttc ggtggtgggc ctatcgccgg ttcgtgttcg gaggccgggt tctggcgcaa
    15661 ggagcctgag ggcgcctgat gtcccgcgca ggctgttcgg ggagatctga gcaggtggaa
    15721 cggcgatcgg ggcggtagtt tctagggatg agcgatcggc ccacactcga tgagatccgg
    15781 cgcgcgccca aggtgctgct gcatgaccat ctggacggcg gggtccgtcc ggcgaccatc
    15841 gtggatctcg cacgggagag cgggtacggg gcgctgccca ccgacgacgc ggagaacctg
    15901 cggctctggt tcgaggaggc ggccgactcg gggtcgctgg aacggtatct ggagacgttc
    15961 gaccacacgg tcggggtcat gcagtcggcg gaggcgctca cgcgggtggc ctacgagtgc
    16021 gccgaggatc tggcgaagga cgggatcgtc tacgcggagg tccggtacgc gcccgagcag
    16081 cacgtcacgg gcgggctgac gctggagcag gtcgtcgagg ccgtgctgga ggggttcgcg
    16141 cgggggcggc gcgaccacgg catccgggtc ggggcgctgg tcacggcgat gcggcaccag
    16201 gcgcggagca aggagatcgc ggagctggcc gtccggtacc gggacgcggg ggtcgtcggg
    16261 ttcgacatcg cgggcgccga ggccgggtac ccgccgaccc ggcacctgga cgcgttcgag
    16321 tacctccagc gggagaacgc gcacttcacg atccacgcgg gcgaggggtt cgggctgccg
    16381 tcgatctggc aggcgatcca gtggtgcggc gccgaccggc tcgggcacgg ggtgcggatc
    16441 atcgacgaca tcgacgtgga cggcggagag ccgaagctcg gacggctcgc cgactacgtc
    16501 cgggacaagc ggatcccgct ggagctgtgc cccacgtcca acatccagac cggagccgcg
    16561 cggtcgatcg cggagcatcc gatcgggctg ctgcggcggc tgagcttccg ggtcacggtg
    16621 aacaccgaca accggctgat gagcgggacg tcgctgtcgg aggagttcgc gaagctctcc
    16681 gaggcgttcg ggtacggctg ggacgacctc cagtggttca cggtgaacgc gatgaagtcg
    16741 gcgttcgcgc cgttcaccga gcggctggag ctgatcaacg gggtgatcaa gccggggttc
    16801 gcgcagctca agtggagccg tccgccggcg tgatcaggag gtctgccagc ggccggtgcc
    16861 gggcacgggc gtcgtgaggt gctccatcag cgcccggtac cgcgcccagg cgccgatgcc
    16921 gtcgccggag ccgtcgccgt ccagcgggaa ccacaggccg ggggaggcgg cgtcgccgat
    16981 ccggcggccg ggcgtctcgg ccgacagcgc gtgctcgatc ccgatctccg cgacgccctc
    17041 cgggccgacg cccatggcca gcggggtcgg gacgccgagc gcgcggctcg ggtaggtgag
    17101 gtcggggagc gcgggcgtcc actgggcgtt gagggtcttc aggatgcccg tccgggcgta
    17161 ctggtccgcg agcttctcca actcggcgag cggcggttcg cggtcggcgg ggcaggcgag
    17221 ggcgaacgcg atcacctcct tcacccccga ggtcacccgg gagacctgca cggtcccgcc
    17281 gaagggcggg acgtcgccgc cgtgcgggcc catgaacacc agcagcgtcg aggcggggga
    17341 gcggcgccgg cacagcgcgg tcaggtccgg cggcgaccac cgcgacagcg cgggctcggc
    17401 cgtcccccag cagcgggggg cggcgccggc gagggcgcgg cccaggtcct cgatcacgga
    17461 cccgagcagc aggccggacg cggcgtcgtg gacgacgctc aggctcacga tcaggtggtg
    17521 gccgaggccg tcggacggaa cctcctggag gaacgtcgcg gacggcccct ccttcgcctt
    17581 ctcggacgcg acgaacgccg cgccgtccca ctccagcggg aaaccggtga agccgtcgta
    17641 gtagccgtcg cccggttcct gcacgaccca ccgcgcctgc ggcgtgccca gcatcatccg
    17701 gagcgggaag gtgatccggg cgtcgtgcgg ggtgaggacc tggaacgcct ggtcgacgct
    17761 cgcgcacttc tcgatcgcgt cggtcagcca ggacgacagc ggcacgagcg ggcggtcctg
    17821 gatggcgacc gcgctcctcg tcgtgacgat gtcgagcgcc gcatgcgtgt tcgtcgtggt
    17881 caccgcgtct cctcaggggc gttcgagggc cagacggcgc cgcccagccg ctccaccatc
    17941 gcgtccgcga accggtgcgc gatgcccggc gccctcgggt cgccgcccga cgcgcgcacc
    18001 tccacccacc agtacgggac ggtcagcccc gcgtccacgg ggccgccgag cacgcgcccg
    18061 acctctccct ccacgtcgac gcgctgcgcc gactcgatgc tgaccagcgg cgatcccgcg
    18121 tcgtcgcgga gcaggatgag ggcgccgtcg ccgccgccgc gcacccgcag ggtctcgccc
    18181 gcggcgacca tgctgtcgac gatcgcgcgc acgtcgggcg cccgctgcgt cagcaccacc
    18241 atgtcgtagg tcatcgcgcc tcctcccgta ccggggcctc ggccagcgcg gtctggacga
    18301 gccgcgcgct ctcccctcgc cgtatccact gcgcgcgccc cggcggcagc gactccgcgt
    18361 agacgcgggg gaacagctgc ccctccgacc ggtccccgga catcaccagc gcgcccgtgc
    18421 cgctctcccg caccgcctgg aggagcgggt cgtagagccc ccgggacgac ccggcgacgc
    18481 ggcgcgccac gacgaagtgc aggccgatgt cgcggccgct cggcacgaac ggcacgaacg
    18541 gggcgagcgg ctgctggccc gccgtggtca gcaggtcgta gtcgtccgcg agcacgacga
    18601 tccggggccc cttcaccccg gcgccgtcgg ggacggcgga cgggtcctcc ggcatgcgct
    18661 ccttcaactc cttggcgacc ccgcccgcga gccccgcgca gatcctcggc gtcggggcgt
    18721 agccgccgac gtaggcctcg ggcgccacgt cgcgcagcga gcggcgcggg tccatcaccg
    18781 cgaacacgac ctgctcgggc gtgtaccggg cgacgagctg ctggacgatc agccgcatca
    18841 ggttggtctt gccggagccg ccgtcgccga gcacgacgag gttctggtcg acgtcgaaca
    18901 ggtcgagcag cagcggttcg agcgcgcgct cctcgacccc gagcggcacc agccggggct
    18961 cgcgctccgg atcgggcagc tcggacaccg ggagccggtg cggcagcacc cgcacgggcg
    19021 gcgtggactc gcccgtccag gcattgcgca ccgccccgac cgccgcctcg gcggcagtgc
    19081 ccagttcggt cgggtcgggg acggcgccga gcgcgggcac cgcgacatgg ccgaacagcc
    19141 cggcgtcggt gagcgcgcga cccggcagct cggcgctgat cgtctcggcg agcttgcggg
    19201 cgaccgtcga gtccgacggg tcgttcagcc gcagctcgac gcgctgcccg aacgtggact
    19261 gcgcggcgat ccgcacgtcg ttccaccgca gcatgcccgc gacgatgtgg atgccgtagc
    19321 cgccgccgcg ctggagcagg tcggagacca tgtcgtcgat ctcctcgaag tcgccacgga
    19381 tcgcgccgaa cccgtccacg accaggacga cgtcggcgca cgacagttct ggcacgctcc
    19441 cggccgcgtg catctgccgc agccgctgga tcccgtcgat gccgtgctgc cggaacacct
    19501 ccatgcggtg ctccagcatc ccgtggacct cctcgaccgt ccggcggatg cgctccaggt
    19561 cggtgcgtcc cgcgacgccg cccacgttgg gcaggccgga cagcacctgg aggccgccgc
    19621 cgaccaggtc gagcccgtac accgcgacct ggcgcggcgt gtgcgtcagc gccagcgaca
    19681 gcacgaacgt gcgcagcagc gtggtcttgc cggtctgcgg accgccgatg atcgcgacat
    19741 gcccgcccgc cgccgtcagg tcgaggttcc acacgccctg ccactggcgg cgcgcgtcgt
    19801 ccagcagccc gatcggcacc cgcagcgggc ccgcctgggc gggcagccgc atgccctgct
    19861 cggtgatccg gacgggcccg gtgaccgcgt ccagcgtggt catggcgggc agcggcggca
    19921 gccagatcat ctgcaccgga cggccgtgcc gggcgagctg gcccacgagc acgtcgagca
    19981 tggtcgggcc ggtggtccgc tccggcagct cggcctcgtc gtcgggcgcg ttccgcaccg
    20041 gcccgtcgag cggcccggcc aggttgtagg cggtgaacgg acgcaccgga agccggtcgg
    20101 cgccctcggc cggtgccgcc accgcgcccc ggtacgggcc cgacacgtag ccgcccttga
    20161 accgcaggta gatgctggtg tcgaccttga ggtagccgaa gccgggcagc gccgggaggt
    20221 ggaacgcgtc gggcgagtcc aggacggtgc ggctctcctc ctcggagaac gtccgcagcc
    20281 cgatccggta cgacaggtag gtctccaggc cgcgcagctt gccgctctcg atgcgctggc
    20341 tcgacagcag caggtggacg ccgatgctgc gcccgatccg gccgatcgac aggaacagct
    20401 cgatgaagtc cggacgcgcg gtgagcagct cgccgaactc gtcgatgatc acgagcaggt
    20461 gcggcagcgg cggcaggtcg ggacgctgcc cgcgcaggtg gttgtagtcg ccgatgttgg
    20521 cgatgttgcc cgcgtcgcgc agcacctgct gccgccgctg cacctcgccc gacaggctcg
    20581 cgtagacccg ctcgatcagc ccggcgtcgt cctccaggtt cgtgatgacg cccgcgacgt
    20641 gcgggagccc gtcgaacggc gcgaacgtcg cgccgccctt gtagtcgacc aggaccatgc
    20701 tcgcctgctc gggcccgtgc gtggccgcga gcgcgagcac cagcgtgcgc agcagctcgc
    20761 tcttgcccga gccggtcgcg ccgacgcaca gcccgtgcgg gcccatgccg aggctggccg
    20821 cctccttcag gtcgaggatc accgggcggc ccgcgtcgtc cagcccgacc gggacgcgca
    20881 ggaacgcgcg ctcgccgcgc ggcgcccaca gccgcgccac gtcgaggtcg ccggggtccg
    20941 ggacgcccag cagcccggcg aagtcgacct cgccgccctg cccggcggtc tcgtccaccg
    21001 actcccggga cagccgcagc ggcgcgacca tccgcaccag gccctccagc atcgccgccg
    21061 ggacgtcgtc gaccgtgccg ctcatctcca ccggctcggg gccgcgcagg tcctcgacgc
    21121 ggacccggtc gccctcgacc gtgatccgca cgccgacgtc gccgggctcg tgcgtccggt
    21181 ccgccagcag gtggacgacc gtcgcggcca ggtcggcgac cgggacgctc tcgtccggcc
    21241 ggacgagttc ggcggccacc tcgccgtgcg tgtcctggaa caccaccagg cggcgcagca
    21301 tcctgaacga gtcgcgccgg ttcagcccgc gccgcacctc ggcggcgtag tcgctgcgcc
    21361 gccgcagctc gtcggccagc agcgccgcca gcttcagcgg cgacgaggcg atcagccgga
    21421 tcggcacccc gccgtcgcgg cggtgctggt cgtgcacgtg cggcagccac ttgagccagt
    21481 cccagtcggc cgagccgccg ccgtaggccg cgccgatcgc gacgtcctcg ggcgcgtgga
    21541 acgcgacgag ctggacgacc atggcgcgca ccagccgcag cacgtccggc cgggagccga
    21601 tcacgctgac gtcgcccgcc atgtccagcg gcagcgtgag cggcatgtcc ggcgcggtac
    21661 ggaagcgctc cagcaccgcg cgcgcctccg aggacatgaa cgggtccgtc gggttgagcg
    21721 ccgtgccctg ctcgcccagc tccagcgagt gcccgggcat cagaccggtg ccgaccctga
    21781 cccgcaggaa gtcctcgtgc gtgcggcgcc gctcccacag ccgcgacggg tcgcggacga
    21841 cgtcgtacag cgcctcgggc ggcgggtcga gcacgcgcgc cagcgtccgg tgcgcgcgct
    21901 cctccgccga cagctcctcc cgcagctcct ccaggaactc caggtagcgc tcgcgctggt
    21961 tcttgcgctg ccgggtgacc tggcccttcc gggagagcaa cagcgcgccg ccgccgagga
    22021 ccgccacgac cagcagcacc gcgccgaacg ccatgaacgc cgggttccgc atgaccgtca
    22081 tgatcgtcag cgagcccatc atgccgacca tgggcaggat cgtcatgagc tggttgccgg
    22141 tcccgcccgc ctcggggaga gtgggaggag cctcgacctg ccggggctcc gcgtcggtcc
    22201 tggggtagac ggtccgtgcg gggcggtgca ccaaccgggt cgtcacgcct gcccacccct
    22261 tcatgtcgag cgattgccgt ccaccctaat gtcggacggg gacaacggta cgaagatcaa
    22321 cttatcggga gtatcgggag cgggatggac gagctgttcg aggtgtcggc cgacgtgcac
    22381 gccctcatcc aggacctgct gcccgtcatc aacccctcgg cccggttcca acccgaattg
    22441 gcgcaggtcg tgcttcccgt cggacggttc gagcccagtg ccaccacctg gacgatcctg
    22501 gagcgctgcg cgcgggccga ccgcgtcgcc tggcccaggc tcgtggagga gtggctggtc
    22561 catgtgagcg atcgcgcggc gctggcgatc ggcgacatcg agcttctggg ggacgttcgc
    22621 aaacggctgc ggatccgcat ggtgcccaag ctcaccgagt ccgagcggca ggggctggcg
    22681 accgtctccg ccggaaggca cttcgacgcc gtgatcatga tcgaccatcc ggagtacggg
    22741 gggccgctca ccctggccag ggcctcgctg ctcggcctca ccgatctcgg cgagctcgcc
    22801 gtgccgaaca cctaccaggt ggagttggcc gacgtcgacg tccacgacca gcccctcacg
    22861 ctgaccgagt cgatccgtgt gatccacaag cccggcagcc ggtacgtctc cgcgctgatg
    22921 gccgagctgc gtcatttcct ccccgacgtg gggaaggcgg gcgcgctggt cgccgttccg
    22981 acgcacagca cgatcctcgc gtatccgatc gtctcggcgg ccatgggcga ggtgttcggc
    23041 ccgttccgcg agctgacgaa ggagatgtac gccgcgtccg acgaccccac gtcgccggac
    23101 gtgttctggt ggcgccacga ccaaccgctc gtcaagctcg acccggaagc gggcgccccg
    23161 ccggagctgg acccgtcgcc gtcgcccgcg cgcaagcgca ggtcgcggtt cgggttcaga
    23221 cggtgagggc cagccggagc gcttcggcgg cgatggcgat cgcggtcagg cgggtggcgt
    23281 aggcgagccg tgcgtggtcg agcgtcgtcc cgacggccag ctgccggtcg aagcccagcc
    23341 tgatcgtgtt cacgccgacc tcggcgagga ttccggcggc gcggtccacg tccacggtcc
    23401 ccgccttgtg cggggtgtgc gaggtgaaca cgaccagcgt gcgcgggagc agcgcccgca
    23461 ggtcgcccga gcccatccag tccaggacgc gtccgacagc cgccgcgccg tccacggtgg
    23521 cgggcgcgac gaggatctgc gcgtgcgcgg ccgccagaac ggcccggtgc agcggggtcc
    23581 gggtccccgc gccgttgtcg gcgaccgtga ccccgaagaa ccggctgagc tggacgcccg
    23641 cggactggta gcggcccgcg tccacgagcc cgcggcccgc gccgaccgtc ccgtaggtgg
    23701 tcggcagcgc ccacagccgc tcgcccagcg gcaccaggaa ctgccgcacc tgctcgaacg
    23761 aggcggtgct gaggtccgcg cccgcgagat cggcgaccgg atgctcgttg cggacgccca
    23821 gccggagcgg cagcgagccc atctccgggt cgaggtccag ggccaggacc cggtcgtcgc
    23881 ggtggcgcgc gaacgccgtc gtgaccagcg ccgacaccgt gctcttgccc gagccctcgc
    23941 gcacccccat caccgcgatc cgcctgccgg tcgtcaccgg atgcgcgatc caccggccgt
    24001 gctcggtgac ctcgcgcacg tcgtcggcgg accggaacgg atgcagcgcc ccccgcagga
    24061 cgcgccgcat gaccgagtca ccgtgcaccg gcccctggac gagcgtctcc ggcgccgtgg
    24121 gcacgaccaa aggcgcaggc cgaggcggcg gcgcagggct cgcctgcggc ggcgggggtg
    24181 ggggtgccgg gttcgctcgg ggcgggggtt ggtcggggcg ggtgaccgag aggtcggacg
    24241 gctgcccgaa cgcgggcggc ggcgacgtcg gcgggggagg gggagggggc tgcgcctgcg
    24301 gggcgtgccg gtgcagcttg ggggcgtcga cgaccgtcag gtcaggatcg ggcgggggca
    24361 cgtccctgtc ctggtcagcc acccgagtcc tttcagaagg tttccaggag ccgttcgaag
    24421 gttccgaagg tgccgacggc gaccgggacg atggccacga ccgcgacccc ctcgacccgg
    24481 ttcatgatcc ggcgcagccg cgcgcgcacg tgctcgggct gctcggaggt gagcac
//
