LOCUS       NZ_JAICDG010000002     11971 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinomadura terrae strain OS3-83 contig2, whole genome shotgun
            sequence.
ACCESSION   NZ_JAICDG010000002
VERSION     NZ_JAICDG010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura terrae
  ORGANISM  Actinomadura terrae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 2162430)
  AUTHORS   Lee,S.D., Yang,H.L., Kim,I.S., Choe,H. and Kim,J.S.
  TITLE     Actinomadura terrae sp. nov. and Actinomadura litoris OS3-89,
            isolated from rhizosphere soil of cactus
  JOURNAL   Int J Syst Evol Microbiol 73 (1) (2023)
   PUBMED   36748505
REFERENCE   2  (bases 1 to 2162430)
  AUTHORS   Lee,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2022) Institute of Jeju Microbial Resources, BioPS
            Co., Ltd., Sancheondan Dongil 16, Jeju 63243, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 141x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022751215.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:12:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,085
            CDSs (total)                      :: 8,002
            Genes (coding)                    :: 7,936
            CDSs (with protein)               :: 7,936
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 2, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 13 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 3 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 123461
            Orig. end                         :: 135432
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAICDG010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11971
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11971
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11971
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6971](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6971)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    637..652
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.88"
                     /tool="antismash"
     gene            747..1451
                     /locus_tag="K2F47_RS10690"
     CDS             747..1451
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="K2F47_RS10690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_242902714.1"
                     /transl_table=11
                     /translation="MTSILLSSANADCRDRVAGVLGRTLGAQVRLVVPDGRSVASALVA
                     TATDLLVVDLTPWRAGHRELVRSVCREGSVLRVPVVLLVDHTARFDEPAGRPELLGALW
                     AGVASIADRRGPVAEVTAAARTAAAGGRYLSPAFARCLLDDPVDGPALLDELFEADPHR
                     PGVLTPREREVLALLASRPSNAWIAERLALSEKTVKYHVSNVLGKLGLRDRGEAAELAA
                     AMSPDHCGTLAS"
     gene            complement(1633..3123)
                     /locus_tag="K2F47_RS10695"
     CDS             complement(1633..3123)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.5"
                     /locus_tag="K2F47_RS10695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_242902715.1"
                     /sec_met_domain="Pkinase (E-value: 2.4e-38, bitscore:
                     128.8, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDLRPEDPRTVGRYTLTARLGAGGMGQVYLGSSPGGRPVAVKLV
                     HAGFAADAEFRRRFKREVEAARRVGGFHTAPVVDADPDADTPWLVTAYVPGPSLATAIA
                     QHGPFPPASARVLGAGLAEALEAVHGAGVVHRDLKPSNVLIAADGPRVIDFGIARAVDA
                     SGITTRAGTPGFMAPELITDGASTPACDVFALGAVLAFAVGVRPFGEGPSEALTYRVVH
                     REPDLGGVPEPLGPLVAACLAKDPAARPAPSDLLGALTLGGDAGAWLPPPVQEMVTRFP
                     TAHPPAPAPTPTRHLPPPQTAPPAQTAPPAPQAVRIDGRITPAAIALTAAVLYSLIWLA
                     IFLLGAGLALGGTSSDRDSVATLIGVVVAIVGAVNCLRAIPRAVWQAIALARPVTFEIG
                     PGGLSLRHGGRRVYYGWHEIGRVVLRRIDDKKKRALCVSLTPGSAQPDYLSPRTPLCYT
                     EPDTGWVVIAPLIRLRTSRREMEKIVARYAGPRWGGHA"
     gene            complement(3230..3601)
                     /locus_tag="K2F47_RS10700"
     CDS             complement(3230..3601)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887062.1"
                     /locus_tag="K2F47_RS10700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4267 domain-containing protein"
                     /protein_id="WP_242902716.1"
                     /transl_table=11
                     /translation="MLAPIAYGLAVLLSLFVLFIGMRFLFQPRLAADGYGVRAKPDGDS
                     AYLSVKGVRDACYGLLGLALLAFADANAAAWFMLVVALAPLGDTVIVLRNGGTRAAAFG
                     IHFATALVVLLSAALLFAV"
     gene            3691..4260
                     /locus_tag="K2F47_RS10705"
     CDS             3691..4260
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017563994.1"
                     /locus_tag="K2F47_RS10705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_242902717.1"
                     /transl_table=11
                     /translation="MSIQARRERERAERERAIVTAARELAEAEGWDAVTTRRLAAEIEY
                     SQPVLYSHFSGKDAIMAAVALEGFAALTAELRAARPDGVAAVAAAYADFGERRPALYDA
                     MFTLAVDLEFASPDSPAPLKEGFGELRETMRPYASGDDLELLTETFWSGLHGLLMLMRH
                     GRLRRAEHERRLALLIGRFSSPVRSR"
     gene            complement(4247..4954)
                     /locus_tag="K2F47_RS10710"
     CDS             complement(4247..4954)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039872.4"
                     /locus_tag="K2F47_RS10710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5825 family protein"
                     /protein_id="WP_242902718.1"
                     /transl_table=11
                     /translation="MIRDLPPVDLTSAAGVAAARDRADVRVLEVSLAELASGTTIPHGK
                     QEPLTWLRVRPAPGELDDEVWPGDEALGALPAAGVIGLTLDVPALPPAPWLIAFLVRVT
                     SFQLPLEWGGPVADLPCGLLFHLTPPAFGDEVAGKWRAAHRYGQCYWRRGHGFVAVQDL
                     REQPGAHFVIHEPGLLALFHRLADPVAVADLGDDDRAHLGDLLDARLAVDLDGVAVRLP
                     YRLRRWPAPVIDF"
     gene            complement(5001..6971)
                     /locus_tag="K2F47_RS10715"
     CDS             complement(5001..6971)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03975.1"
                     /locus_tag="K2F47_RS10715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_308198393.1"
                     /sec_met_domain="TIGR03975 (E-value: 1.2e-156, bitscore:
                     519.4, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.2e-11, bitscore: 42.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAAFSSGARFPSITGGRHVRVTLAVMPWHLMTAPNGAAGVLAAA
                     LAPDHEVTTYYGSISFAEQMLGEAEKAEPGTARARLLPEAYMYVAEEGFTGGIGEWLFT
                     GALYGHEQFPDEASAACEAIGFDPDVAEQIFALAPAFADAAAREIVAGRPEVVGFTTTF
                     SQTIPALAVARRLRALDPGITIVFGGSNCDDTMGAALHRCFSEIDFVVRREGEAPLRSL
                     LAALAADDADDTARLAAIPGLCWRDADGTSRANPEGAALPGGADFPPMDQTAYFDRLEE
                     SPVADYIQPALMMESARGCWWGERHHCTFCGLSDLILPFRSKAPDRVVDELVAGIERHQ
                     VLDVLTTDNIVDKNYYETVFPALEKSDLDLRVMYEIKSNITPEQARALRGAGVIQVQPG
                     IENLHSLPLKLMRKGVTGTNNVATLRELQEQSLTVLWNYLVGFPGETDECYREVIDQIP
                     LLYHLQPPLGAHRIALERFNPYFDDPGLGFAERRPRSWYRGVFPDLSEPDLNDVAYLFE
                     TPDQGVGGATLAGLKAAFDAWREAYATSALTHRAVAGRLHLYDRRAGRRAADHVLDDPA
                     EVAAYTALGRGRSAESLARHLAADGWPVDAAWTSTFIADLAALGLVYRESGRAVTLSTG
                     HDATAVRGTAIPTPAMVGAGT"
     gene            7213..8463
                     /locus_tag="K2F47_RS10720"
     CDS             7213..8463
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS10720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242902720.1"
                     /transl_table=11
                     /translation="MTGPDRGTGSSNSYRALLAIPGTARLYFGYLLARMPVGVIGLSLL
                     LLGQDTGGTARSGLLVGAFSAALMIATPLLGRALDTYPAGRVLSMAASVQCAALFLLAL
                     CWSAPRPPTGLLLAGALLAGASLPPAGPALRVALPVFVPDDLLTTGFTAEAVILETVYV
                     IGPLLVGGLGAVAGWLPLAAAGGCTAAGVAVMLSSGRLAGPCAGADTAPARALWTLGPL
                     ADGGVRRLLLGAFLFLPALAVVEVAVAAVAGERDRPELLGVVMACSAVASLAGGLLFGM
                     RRWPGSPASHVAVLAGWFAVASVLGALAPGPWPVGAAVALGSLVVAPALALLGRIGGVV
                     APEGRAAETHTWLSTMNNCGQAATLPLAGFLAERTGPEGAFLLAAGLAGAAALFLLNNR
                     RHLTPTATSRPRQPVGT"
     gene            complement(8512..9888)
                     /gene="gdhA"
                     /locus_tag="K2F47_RS10725"
     CDS             complement(8512..9888)
                     /EC_number="1.4.1.4"
                     /GO_function="GO:0016639 - oxidoreductase activity, acting
                     on the CH-NH2 group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gdhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291805.1"
                     /locus_tag="K2F47_RS10725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADP-specific glutamate dehydrogenase"
                     /protein_id="WP_242902721.1"
                     /transl_table=11
                     /translation="MPLSPRLPAAPETLALLEESYERVLRRDPGEPEFHQAVHEVLESL
                     PPVLAARPGLAAAKMVERVIEPERQIVFRVPWQDDAGEIHVNRGFRVEFNSALGPYKGG
                     LRFHPTVNLGVVKFLGFEQIFKNALTGLGIGGGKGGSDFDPHGRSDAEVMRFCQSFMTE
                     LQRHIGDHTDVPAGDIGVGGREIGYLFGQYRRVTNRWEAGVLTGKGLPWGGSAGRTEAT
                     GYGNVMFTAEMLRRRGEDLDGQQVVVSGSGNVAIYTIEKAQALGANVVTVSDSGGYVVD
                     EKGIDLDLLKKVKEIDRGRVSDYAEQRGASARYVAGGSVWDVPADIALPSATQNELDEN
                     AAAVLVRNGVKAVSEGANMPATPGAVHVFQDAGVAFGPGKAANAGGVAVSALEMRQNAG
                     RDSWTFERVESELSAIMTSIHDTCFETAERYGAPGDYVVGANIAGFERVAEAMLAQGLI
                     "
     misc_feature    9991..10006
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.19"
                     /tool="antismash"
     gene            10099..11325
                     /locus_tag="K2F47_RS10730"
     CDS             10099..11325
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013884.5"
                     /locus_tag="K2F47_RS10730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyltransferase"
                     /protein_id="WP_242902722.1"
                     /transl_table=11
                     /translation="MDALRGWAALTVALHHASYVYVPDVQKWMAEHFDPGRYGVLVFFL
                     VSGYIVPASLERRGSVRGFWIGRFFRIYPMLALCCLAAVLPFLFGVLGLRAGLERYDPV
                     TAVLAHLTMLQDLLAVPNAINVLWTLTYEMAFYLLIVALFVVGGHRRSAPVASGFALAA
                     LLVGGLIPSTLLSRTAGVGPLVIAITLGLVIAISAAVSDRPGLRVFGGVLGGLLALALV
                     AANSRVYAWEGLTYPAIMFTGTAFYRAEHRQIGRRAAALAIAVVLTGVIAAGTVHAGTA
                     AQARQNQLTWTLPIVLAFVTFFGAWLLRRRGFPRWALTLGAASYSVYLLHPILLMVDTQ
                     FIGATGHQNELGLAAFVAVLVTASWACHRWIELPAQRLGRHLTRRLLRPAAPPPTTPPT
                     DSASHALTP"
     misc_feature    complement(11384..11404)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.34"
                     /tool="antismash"
     misc_feature    11410..11423
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.8"
                     /tool="antismash"
ORIGIN
        1 ccgcgcagaa ccggcacggc ccggccaccg agtgggcggc cgaggcggac cggcacgccc
       61 acccgagcct gcccgtctcg accggcctgg ccgcgctcgc ccgcgcgcac tccctgctcg
      121 gcaccgaccc gggcgccgcc gccgaccacg ccaggggcgc cgccgacgtg ctggcgagca
      181 acgagttccc gctggacgcc gggcgggcgc tgctcaccgc cgcgaccggc gccgcgcgcg
      241 cgtcccaccg cgacaccgcc aaggccgacc tgcaacgcgc ggcggaggtg ttcggcgcct
      301 gcggcgcggc ctcgttcctg cggcgcgtgg tgcgcgagca gcggcggctc gggatctacg
      361 tcccggtgcg cggccgctcc tccggcccgc acgacctgtc gcgccgcgag ctggaggtgg
      421 ccgagctggt ctcggccgga cgcaccaacc agcagatcgc cgaggcgctg ttcatcagcg
      481 cccgcacggt cgagagccac ctcgcgcaca tcttcgccaa gctcggcgtc tcgtcccgcg
      541 cgggcgtcgt cagcgcgctc aagaccccct cctcctgagc ctcctgggcc tcccgggttc
      601 acgggactcg cgcactacgt aggacgggga atcggcaata tcagtgattc tccggatgtg
      661 cgtccgtaac cccatcggcg agcatcgccg cagaggtgat cgggagtcgg gagtcccgct
      721 cgccgaggcg ccgggaggtg agggacgtga cgtcgatact gctgagctca gccaacgccg
      781 actgccgcga ccgggtggcg ggcgtcctcg gtcggacgct cggagcccag gtcaggcttg
      841 tcgtgccgga cgggaggtcg gtggcctccg cgctcgtcgc caccgcgacc gacctgctcg
      901 tagtcgacct gaccccctgg cgcgccgggc atcgggaact ggtccggtcg gtgtgccggg
      961 aggggagcgt gctccgcgtc ccggtcgtgc tgctcgtgga ccacaccgcg cggttcgacg
     1021 agccggctgg acggcccgag ctgctgggcg cgttgtgggc cggtgtcgcg agcatcgccg
     1081 accggcgggg gccggtcgcc gaggtgaccg ccgccgcccg gacggccgcc gccggtggcc
     1141 gctacctctc gcccgcgttc gcccgctgcc tgctggacga ccccgtcgac gggcccgcgc
     1201 tgctggacga gctgttcgag gccgacccgc accgtcccgg cgtgctgacg ccgcgggaac
     1261 gggaggtgct ggccctgctg gcgtcccggc cgtccaacgc ctggatcgcc gagcggctcg
     1321 cgctgagcga gaagaccgtg aagtaccacg tgtcgaacgt cctcgggaag ctcgggctgc
     1381 gcgaccgggg cgaggccgcc gagctggccg cggccatgtc gcccgaccac tgcgggacgc
     1441 tggcctccta gctggttcat tgaagtcccg gcccacgtcc ctcgcctggc ggctcgggac
     1501 gtgaccgtgc ctttgcgggc gcggaatcgc ttcgcgatct tcgcggtggg gcctcgcctt
     1561 cggcgtcggc cccaccgctc agctacgcgc ccgcgtgacg gctgaggtcg ctgcggaggg
     1621 cgtcctagcc tgtcaggcgt ggccgcccca ccgggggccc gcgtaccggg cgacgatctt
     1681 ctccatctcc cgccgcgagg tccgcagccg gatcagcggg gcgatcacga cccagccggt
     1741 gtccggttcg gtgtagcaga gcggggtgcg cgggctcagg tagtcgggct gcgcgctccc
     1801 gggggtcagg gacacgcaca gcgctcgctt cttcttgtcg tcgatgcggc ggagcacgac
     1861 ccgtccgatc tcgtgccacc cgtagtagac gcggcgtccg ccgtgccgca ggctgagccc
     1921 gccgggaccg atctcgaacg tcacgggccg cgccagcgcg atggcctgcc agacggcgcg
     1981 cggaatcgcc ctgaggcagt tcaccgcgcc gactatggcc acgacgacgc cgatcagcgt
     2041 ggcgacgctg tctctgtcgg acgaggtgcc gccgagggcg agcccggcgc cgagcagaaa
     2101 gatcgcgagc cagattagcg agtagaggac ggccgcggtg agcgcgatcg cggcgggcgt
     2161 gatccgcccg tcgatccgca cggcctgcgg cgcgggcggt gcggtctgcg cgggcggggc
     2221 ggtctgcgga ggcgggaggt ggcgcgtcgg cgtgggggcg ggcgcgggcg ggtgcgcggt
     2281 ggggaagcgg gtgaccatct cctggacggg cggtggcagc caggcgcccg cgtccccacc
     2341 cagggtcagg gcgccgagca ggtcggacgg cgccggacgg gccgccgggt ccttggcgag
     2401 gcaggccgcg accagggggc cgagcggctc cggcacgccg ccgaggtcgg gctcccggtg
     2461 gacgacccgg taggtcagcg cctccgaggg cccctcgccg aacggccgca ctccgaccgc
     2521 gaaggcgagc acggcgccga gcgcgaacac gtcgcaggcg ggggtgctcg ccccgtccgt
     2581 gatcagttcg ggggccatga agccgggcgt cccggcgcgg gtggtgatcc cggacgcgtc
     2641 gaccgcgcgg gcgatgccga agtcgatgac gcgcggtccg tcggcggcga tcagcacgtt
     2701 ggacggcttg aggtcgcggt gcacgacccc cgccccgtgg acggcctcca gcgcctcggc
     2761 cagcccggcg ccgagcaccc gggccgaagc cggggggaag ggcccgtgct gggcgatcgc
     2821 cgtggcgagc gagggcccgg ggacgtaggc ggtgaccagc cagggcgtgt cagcgtcggg
     2881 gtcggcgtcc acgaccgggg cggtgtggaa gccgccgacc cgccgggccg cctccacctc
     2941 ccgcttgaac cggcgccgga actcggcgtc ggcggcgaaa ccggcgtgga cgagcttgac
     3001 ggcgacgggc cgcccgccgg gcgatgaccc gaggtagacc tggcccatcc cgcccgctcc
     3061 gaggcgggcc gtcagcgtgt accggccgac ggtacggggg tcctcgggtc gcagatcgtc
     3121 cacagccgct ccttcagttg ggaccctccg cacaagattc aagcggtgtg gggaagtttc
     3181 ggaaagcccc tggacggcgg cgatcgggcc gcgcgcaggc cgcgatcggt cagacggcga
     3241 acagcagcgc ggcgctgagc aggacgacca gcgcggtcgc gaagtggatg ccgaacgcgg
     3301 cggccctcgt cccgccgttg cggagcacga tcacggtgtc gccgagcggg gcgagcgcga
     3361 cgacgagcat gaaccaggcg gcggcgttgg cgtcggcgaa ggcgagcagg gccaggccca
     3421 gcagcccgta gcaggcgtcg cgcacgccct tgacgctcag gtaggcgctg tcgccgtccg
     3481 gcttggcgcg gacgccgtag ccgtccgccg ccaggcgcgg ctggaacagg aaccgcatgc
     3541 cgatgaacag gacgaacagg ctgagcagga cggccaggcc gtaggcgatc ggtgcgagca
     3601 tgacgactcc cgtggagcta gcagtgctag gaacacgatc gacgttagca gagcattggc
     3661 agcatggcta gcgatgctag aatccggggc atgtcgatac aggcgcgccg ggagcgcgag
     3721 cgggcggaac gggagcgggc gatcgtcacg gccgcgcggg agctggccga ggccgaagga
     3781 tgggacgcgg tgacgacgcg gcggctcgcg gccgagatcg agtacagcca gcccgtcctc
     3841 tacagccact tctccggcaa ggacgcgatc atggcggcgg tcgcgctgga ggggttcgcc
     3901 gccctgaccg ccgagctgcg cgcggcccgt ccggacggcg tggcggcggt cgcggcggcc
     3961 tacgccgact tcggcgagcg gcggcccgcg ctgtacgacg cgatgttcac gctcgccgtc
     4021 gacctggagt tcgcgagccc cgactccccg gcaccgttga aggaggggtt cggcgaactg
     4081 cgcgagacca tgcgccccta cgcgagcggc gacgacctgg agctgctcac cgagacgttc
     4141 tggagcgggc tgcacggcct gctcatgctg atgcgtcacg gccgcctgcg ccgcgccgag
     4201 cacgaacggc ggctcgcgct gctgatcggg cggttctcgt ccccggtcag aagtcgatga
     4261 cgggcgcggg ccagcggcgc agccggtagg ggagccgcac cgccacgccg tcgagatcga
     4321 cggcgagccg cgcgtccagc aggtcgccca ggtgggcgcg gtcgtcgtcg ccgaggtccg
     4381 cgacggcgac cgggtcggcg aggcggtgga agagcgcgag caggcccggt tcgtggatga
     4441 cgaagtgggc gcccggctgc tcgcgcagat cctggacggc cacgaacccg tggccgcgcc
     4501 gccagtagca ctggccgtag cggtgcgcgg cgcgccactt gcccgcgacc tcgtcgccga
     4561 acgccggggg cgtcaggtgg aacagcagcc cgcacggcag gtccgcgacc gggccgcccc
     4621 actccagcgg cagctggaac gacgtcaccc ggacgaggaa cgcgatcagc cagggcgcgg
     4681 gcggcagggc cgggacgtcc agcgtcaggc cgatgacccc ggcggcgggc agggcgccga
     4741 gcgcctcgtc accgggccat acctcgtcgt cgagttcacc cggcgccggg cggacgcgca
     4801 gccacgtcag cggctcctgt ttcccgtgcg ggatcgtcgt gccggacgcc agctcggcga
     4861 gcgacacctc cagcacgcgg acgtcggcgc ggtcccgcgc ggcggcgacc ccggcggcgc
     4921 tggtcaggtc gaccggcggc agatcgcgga tcatcgtgct ccacaggtgg tcgtgtatcc
     4981 gccggtcgtg tgccggccgg tcatgtgccc gcgccgacca tggcgggggt ggggatggcc
     5041 gtgccgcgga ccgcggtcgc gtcgtgcccg gtggacagcg tcaccgcgcg tcccgactcg
     5101 cggtagacga gcccgagcgc ggcgaggtcg gcgatgaacg tcgaggtcca ggcggcgtcg
     5161 accggccatc catcggcggc gaggtgccgc gcgaggctct cggccgaacg cccgcgcccg
     5221 agcgcggtgt aggcggcgac ctcggccggg tcgtccagga cgtggtcggc ggcgcgccgc
     5281 ccggcccgcc ggtcgtacag gtgcagccgc ccggcgacgg cccggtgggt gagcgccgag
     5341 gtcgcgtacg cctcgcgcca ggcgtcgaac gccgccttca gcccggccag cgtggcgccg
     5401 ccgacgccct ggtcgggcgt ctcgaagagg taggcgacgt cgttcaggtc cggctcgctc
     5461 aggtcgggga acacgccccg gtaccaggat cgcggacggc gctcggcaaa tcccaggcca
     5521 gggtcgtcga agtacggatt gaaacgttcg agtgcgatcc ggtgcgcgcc gagcggcggc
     5581 tggagatggt agaggagggg gatctggtcg atcacctcgc gatagcactc gtcggtctcc
     5641 ccggggaagc cgacgagata gttccagagc acggtgaggc tctgctcctg gagctcccga
     5701 agcgtcgcga cgttgttcgt accggtgacg cccttgcgca tcagcttcag cggcagcgaa
     5761 tggaggttct cgattcccgg ctgcacttgg atgacccccg cgccgcgcaa cgcgcgggcc
     5821 tgctccggcg tgatgttcga cttgatctca tacatcaccc gcagatcgag atcgctcttc
     5881 tccagggccg ggaaaaccgt ttcatagtag ttcttgtcaa cgatgttgtc ggtggtgagc
     5941 acatcgagca cctgatgcct ctcgatgccc gcgacaagct catcgacgac ccggtcgggc
     6001 gccttcgaac gaaacggcag aatgaggtcg gagagcccgc agaaagtgca gtggtgccgc
     6061 tcgccccacc agcatccgcg cgccgactcc atcatcagcg cgggctggat gtagtcggcg
     6121 accggcgatt cctccagccg gtcgaaatag gcggtctggt ccatcggagg gaagtcggcg
     6181 ccgccgggca gcgccgcgcc ctcggggttc gcgcgggacg tcccgtccgc gtcgcgccag
     6241 cacagcccgg gaatcgcggc cagccgcgcg gtgtcgtcgg cgtcgtcggc ggccagggcc
     6301 gccagcaagg agcgcagcgg cgcctcgccc tcccgccgca ccacgaaatc gatctctgag
     6361 aagcagcggt gcagcgcggc gcccatcgtg tcgtcgcagt tggagccgcc gaagacgatc
     6421 gtgatgcccg ggtcgagcgc gcgcagccgc cgcgccaccg cgagcgccgg aatggtctgc
     6481 gagaacgtcg tggtgaaccc cacgacctcc ggccggcccg cgacgatctc ccgcgcggcc
     6541 gcgtcggcga acgcgggggc gagcgcgaag atctgctcgg cgacgtccgg gtcgaagccg
     6601 atcgcctcgc aggcggcgga cgcctcgtcc gggaactgtt catgcccgta gagcgcgccc
     6661 gtgaaaagcc attcacctat tccgccggtg aatccctctt cggcgacgta catgtacgcc
     6721 tcgggcagca accgtgcccg cgcggtgcca ggctctgcct tttcggcctc gccgagcatc
     6781 tgctcggcga aggaaatgct gccgtagtac gtggtgacct cgtggtccgg cgcgagggcc
     6841 gccgccagga cgccggccgc gccgttcggc gcggtcatga ggtgccaggg catgaccgcg
     6901 agggtcaccc gcacgtgtcg acctccggtg atggatggga aacgagcacc tgacgaaaac
     6961 gcggcgcgca cccggaaagg ggcccggccg cgctcgggag ccgtcagaac tcgtgccgct
     7021 ggctggccgt ctgctgctta cggattacct ttcgcttcat gccgacctcc cttctgggct
     7081 ggaagtttca cgcacctttt ctacccgccg cgaggagggc catcgcaccg cagtggccga
     7141 tgtcggccaa gatcaggcac ttttccgcca agccgtgtgc ggaccgtgct tacctgggtg
     7201 ctggaggtga aaatgacggg gccggaccgg gggacgggaa gcagcaactc ctatcgcgcc
     7261 ctgctcgcca ttccgggcac cgcgcggctg tatttcggat atctgctcgc ccggatgccg
     7321 gtcggcgtca tcgggctctc cctgctgctg ctcggccagg acaccggcgg caccgcccgc
     7381 tccgggctgc tggtcggcgc gttctccgcc gcgctcatga tcgcgacgcc gctgctcggc
     7441 cgcgcgctcg acacctatcc cgccggtcgg gtgctgtcga tggcggcgag cgtccagtgc
     7501 gcggccctct tccttctcgc gctctgctgg tcggcgcccc gaccgccgac cggcctgctc
     7561 ctcgcgggcg ccctgctcgc gggcgcgtcg ctgcccccgg ccgggccggc gctgcgggtc
     7621 gcgctcccgg tcttcgtccc cgacgacctg ctgaccaccg ggttcaccgc cgaggccgtg
     7681 atcctggaga ccgtctacgt gatcggcccg ctgctggtcg gcgggctcgg cgcggtcgcg
     7741 ggctggctgc cgctcgcggc ggcgggcggc tgcaccgccg ccggggtcgc ggtgatgctg
     7801 tcgagcggac ggctcgccgg cccctgcgcc ggcgccgaca ccgcccccgc ccgcgcgctg
     7861 tggacgctgg gcccgctcgc cgacggcggc gtccggcggc tgctgctcgg cgcgttcctc
     7921 ttcctccccg ccctcgcggt cgtcgaggtc gccgtcgccg ccgtcgcggg ggagcgcgac
     7981 cgtcccgaac tgctcggcgt cgtgatggcg tgctccgccg tcgcgagcct ggcgggcggc
     8041 ctgctgttcg gcatgcgccg ctggcccggt tcgccggcct cccacgtggc ggtgctcgcg
     8101 ggctggttcg cggtggcgtc cgtcctcggc gcgctggccc ccgggccctg gccggtcggc
     8161 gcggcggtcg ccctgggcag cctcgtcgtc gcccccgcgc tcgcgctgct gggccggatc
     8221 ggcggtgtcg tcgcccccga gggccgcgcc gccgaaaccc atacctggct gtccaccatg
     8281 aacaactgcg gtcaggcggc gacgctcccg ctggccgggt tcctcgccga gcggacgggc
     8341 cccgagggcg cgttcctgct ggctgcgggc ctggccggcg ccgcggcgct gttcctgctg
     8401 aacaaccgcc gccacctcac gcccaccgcc acgtcccgcc ccagacaacc cgtgggaacc
     8461 tgatcccacg acgggacggg acgcggctcg gctcctagat gagcccccgt gctagatgag
     8521 cccctgggcg agcatcgcct cggcgacgcg ctcgaacccg gcgatgttgg cgccgacgac
     8581 gtagtcgccg ggcgcgccgt accgctcggc ggtctcgaag cacgtgtcgt ggatcgacgt
     8641 catgatcgcc gacagctcgg actcgacccg ctcgaacgtc caggagtcgc ggcccgcgtt
     8701 ctgccgcatc tccagcgcgc tcaccgcgac cccgcccgcg ttggcggcct tgcccggccc
     8761 gaacgcgacg cccgcgtcct ggaacacgtg caccgcgccg ggcgtcgccg gcatgttcgc
     8821 gccctccgac acggccttga cgccgttgcg gacgagcacc gccgccgcgt tctcgtccag
     8881 ctcgttctgc gtcgcggacg ggagcgcgat gtcggcgggc acgtcccaga cgctgccccc
     8941 cgccacgtac cgcgccgagg cgccgcgctg ctcggcgtag tcggacaccc ggccccggtc
     9001 gatctccttg accttcttga gcaggtcgag gtcgatgccc ttctcgtcca ctacgtagcc
     9061 gccggagtcg gagaccgtga cgacgttcgc gccgagcgcc tgcgccttct cgatcgtgta
     9121 gatcgccacg ttgcccgagc cggacacgac gacctgctgg ccgtcgaggt cctccccgcg
     9181 ccgccgcagc atctcggcgg tgaacatgac gttgccgtag ccggtggcct ccgtccggcc
     9241 cgcggacccg ccccacggca gccccttgcc ggtcagcacg cccgcctccc agcggttcgt
     9301 gacccgccgg tactgcccga acaggtagcc gatctcgcgc ccgccgaccc cgatgtcgcc
     9361 cgccgggacg tcggtgtggt cgccgatgtg ccgttgcagc tcggtcatga acgactggca
     9421 gaaccgcatg acctcggcgt cggagcggcc gtgcgggtcg aagtcgctgc cgcccttgcc
     9481 gccgccgatg ccgagcccgg tcagcgcgtt cttgaagatc tgctcgaagc cgaggaactt
     9541 caccacgccg aggttcacgg tcgggtggaa ccgcagcccg cccttgtacg gcccgagcgc
     9601 gctgttgaac tcgacccgga acccgcggtt cacgtggatc tcgcccgcgt cgtcctgcca
     9661 cgggacgcgg aagacgatct gccgctccgg ctcgatgacc cgctccacca tcttcgccgc
     9721 cgcgagcccg ggacgcgcgg ccagcacggg cgggagtgac tccagcacct cgtggacggc
     9781 ctggtggaac tcaggctcgc ccgggtcgcg gcgcaggacc cgctcgtagg actcctccag
     9841 cagggccagg gtctccggcg ccgccgggag gcggggggac aagggcatgg gtgattcctt
     9901 tcgcagaaca acgacctttg tacctgcccg ggagaaccat cctcgcaccc tgcgatcatc
     9961 cgcgcgggcc gaacgccgcc ccgcccgccc ttgaccgcat gatctgacaa cccgctcacc
    10021 ccgcggccca gcgcgcccta ctctgtcggg atgatcccca atgcggttga gtcctccgca
    10081 atcgcccgac ttggctggtt ggacgcgctg cggggatggg cggcgctcac ggtcgcgctc
    10141 catcacgcga gctatgtcta cgttccggac gtgcagaagt ggatggcgga acacttcgac
    10201 cccggccgct acggagtcct ggtgttcttc ctggtcagcg gctatatcgt accggcgtcc
    10261 ctggagcggc gcggcagtgt ccgcgggttc tggatcggac ggttcttccg catctacccc
    10321 atgctcgcgc tgtgctgcct ggcggcggtg ctccccttcc tcttcggcgt cctcgggctg
    10381 cgcgcgggac tggagcgcta cgacccggtg acggccgtcc tggcgcatct gaccatgttg
    10441 caggatctgc tcgccgtccc caatgccatc aacgtcctgt ggacgctcac ctacgagatg
    10501 gccttctacc tcctgatcgt cgcgctgttc gtcgtcgggg ggcaccgccg ctccgcgccg
    10561 gtcgcctccg gtttcgccct ggccgcgctg ctggtgggcg gcctcatccc gtccacgctc
    10621 ctgtcccgca ccgcgggcgt cggcccgctg gtcatcgcga tcacgctcgg gctcgtcatc
    10681 gcgatctccg ccgccgtgtc ggaccgtccc gggctgcgcg tcttcggcgg cgtcctcggc
    10741 ggcctgctcg ccctcgcgct ggtcgccgcc aacagccgcg tctacgcctg ggagggcctg
    10801 acctaccccg cgatcatgtt caccgggacg gcgttctacc gcgccgagca ccgccagatc
    10861 ggccgccgcg ccgccgccct cgcgatcgcc gtcgtcctca ccggcgtgat cgccgccggg
    10921 actgtccacg cggggacggc cgcccaggcc cggcagaacc agctgacctg gacgcttccg
    10981 atcgtgctgg ccttcgtgac cttcttcggc gcgtggctgc tccgccgccg cggcttccct
    11041 cgctgggccc tcacgctcgg tgccgccagc tactcggtct acctcctgca cccgatcctg
    11101 ctgatggtcg acacccagtt catcggcgcc accggccatc agaacgaact gggcctggcc
    11161 gccttcgtcg ccgtcctcgt caccgcgagc tgggcctgcc accgctggat cgaactcccg
    11221 gcccaacgcc tgggccgcca cctgacccgc cgcctcctcc gcccggccgc ccctccgccg
    11281 accacgcccc ctacggactc ggcctcccac gccctgactc cctgacgcgc tcccagaaat
    11341 cggctgcgcg tttaggtgcc gaggcgggcg attatttcca cgccaataat cgggtcgtcg
    11401 ataaaagcca tgacggagat caacggactt gttatggtct ggcccgggga caacggaacc
    11461 gttgtatccg caggccggtc atcgcgtcct ggagggtcga tgcgccacct cggcgtgcag
    11521 atcgtccacg ccgccgtgct cgcggcgtcg gtgctgctcg cgttcctcgt gatgcaggat
    11581 ctcgacaccg aaccgccgcc gggagcggcg gggacgatct cgattcagga cgctcgcaaa
    11641 ggcgcggacg gaacgcgcgc cgtccgatta gtggacgcgt acgcgcgcga ccatcacgtg
    11701 tcggtcgtgc gagaggtctg ggacctccgt caacccgacc ggctccggcg cttctacatc
    11761 gccacgggcg accccggctc ggcccccgcg tcctggctgg agcgagggtt tccgtccttc
    11821 ggccaccgcg tccgcaccga gacccttccc tttgcgcagg ccgcgtccgt cgatccgaag
    11881 ggcgagtacc aggtctacgg ccccgagcgc gcgatcgtgg aactgcgcgc cgcgctcgcc
    11941 gactccggct tcgacggaga aatcgtccgg c
//
