LOCUS       NZ_JAICDG010000001     11884 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Actinomadura terrae strain OS3-83 contig1, whole genome shotgun
            sequence.
ACCESSION   NZ_JAICDG010000001
VERSION     NZ_JAICDG010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura terrae
  ORGANISM  Actinomadura terrae
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 2300701)
  AUTHORS   Lee,S.D., Yang,H.L., Kim,I.S., Choe,H. and Kim,J.S.
  TITLE     Actinomadura terrae sp. nov. and Actinomadura litoris OS3-89,
            isolated from rhizosphere soil of cactus
  JOURNAL   Int J Syst Evol Microbiol 73 (1) (2023)
   PUBMED   36748505
REFERENCE   2  (bases 1 to 2300701)
  AUTHORS   Lee,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-FEB-2022) Institute of Jeju Microbial Resources, BioPS
            Co., Ltd., Sancheondan Dongil 16, Jeju 63243, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 141x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022751215.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 06:12:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,085
            CDSs (total)                      :: 8,002
            Genes (coding)                    :: 7,936
            CDSs (with protein)               :: 7,936
            Genes (RNA)                       :: 83
            rRNAs                             :: 5, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 2, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 13 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 3 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:31:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2024338
            Orig. end                         :: 2036222
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAICDG010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11884
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="7"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11884
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11884
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6884](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6884
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(461..475)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    694..707
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.82"
                     /tool="antismash"
     gene            731..1570
                     /locus_tag="K2F47_RS09030"
     CDS             731..1570
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS09030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242902303.1"
                     /transl_table=11
                     /translation="MPTDRPNPLRLAILGIDGSGKSTVARCLAERALVGGRHAVLSCVR
                     PHENPDAPLHELSRHLDVLSKEADRLGSPELKLAVLYLQMCTYGVGERFVTRELGVDVV
                     VSERHPVIDALAYLPLYRSAIVRAAGPGRADAVRAKLAALPAESVEAAAAWCEALGRRS
                     ARPAPKLETLAGELVALAGRPAAEQIAEFRVRFGTGLPDIAVLLDVAVETAADRIGARD
                     RRAEQHERPDRLIRLRDGYDRALPAFGAVALHRIQVGARPPGDVAAEIARLVTAGAR"
     gene            1567..2229
                     /locus_tag="K2F47_RS09035"
     CDS             1567..2229
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039369.4"
                     /locus_tag="K2F47_RS09035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6182 family protein"
                     /protein_id="WP_242902304.1"
                     /transl_table=11
                     /translation="MTGPSREVLGAAWDARMERVRLASRELRGPLPRTAAVAVLREFTP
                     RAFLGSAVAFARGLPPARRAAWYASYSRTIFLAGDPGNLAGRHPCDHLSGDGSIAWYDP
                     APMTEREGLRRLLRPFRGPVGIVGPAEEELPIGEGDGVARLDVPVADLSVEDYLVNVNH
                     LLAEAVMDGLLTGVGRLLVRHLPRDSEVPARCDRIRVSVGDGTAGTLRAHAYLTLTP"
     gene            2376..2732
                     /locus_tag="K2F47_RS09040"
     CDS             2376..2732
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653202.1"
                     /locus_tag="K2F47_RS09040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_242902305.1"
                     /transl_table=11
                     /translation="MSAPLYQLKAEFFKTLGHPARIRVLELLSERDHAVAEMIPEVGIE
                     PAHLSQQLAVLRRAGLVAARKEGATVIYSLTSPRVAELLAVARAILTGVLSGQAELLDD
                     LRASGVTAEGPHRS"
     gene            2875..3360
                     /locus_tag="K2F47_RS09045"
     CDS             2875..3360
                     /EC_number="1.-.-.-"
                     /GO_component="GO:1990204 - oxidoreductase complex
                     [Evidence IEA]"
                     /GO_function="GO:0008137 - NADH dehydrogenase (ubiquinone)
                     activity [Evidence IEA]"
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0022900 - electron transport chain
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012855005.1"
                     /locus_tag="K2F47_RS09045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADH-quinone oxidoreductase subunit B family
                     protein"
                     /protein_id="WP_242902306.1"
                     /transl_table=11
                     /translation="MKDLLRRIRRTGRGAEAPPAPRAAAAPPCARALDASVRVRHVDAG
                     SCNGCEVEIASAFGPVYDAGRYGVRQAASPEHADALLVTGPVTRNMEAALRRAYEAVPE
                     PKVVVALGDCARDRGVFAEAYGVAGAVGDVVPVDVEVPGCPPEPEAIVAALRGLTGR"
     gene            3534..4850
                     /locus_tag="K2F47_RS09050"
     CDS             3534..4850
                     /EC_number="1.6.5.9"
                     /GO_function="GO:0008137 - NADH dehydrogenase (ubiquinone)
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012566.5"
                     /locus_tag="K2F47_RS09050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADH-quinone oxidoreductase subunit C"
                     /protein_id="WP_242902307.1"
                     /transl_table=11
                     /translation="MYLFTRTGPDRRTELHVRLDPDAPVVPSLARASVPAGRFEREMHD
                     LYGIVPRDHPQPGTLVRHRHWPSGWYPMREDAGSPPEFGDPEVPAGPVPAGLTGPGHFG
                     FCVAGESIRKVEARPGFVHKGIERLFQGRDPAAVVPLAERVSGDTAVGHTLAFCLAVEE
                     AAGVRVAPGTQRARALLLELERLYNHVTDLGALCDEIGDQVLSARFGRVREQLLRLNAR
                     ITGHRLLRGGVRLGGVLLRALPDPGTLAAVGADLAELADLALGRTAVADRLTGTAPLAA
                     GAARDLGALGYVARASGLDADARRDHPFTDLRPALTVPTAGTGDVLARFQIRAREIAAS
                     IAIIVDLTYGLGPGSAVYWPPLAPPDGPASGVGIVEGWRGTIVHRVELAPGGTLTRTKI
                     VDPSFFNWPALPVALEGALVPDLPLVDRSFNLSHAGNDL"
     gene            5001..6884
                     /locus_tag="K2F47_RS09055"
     CDS             5001..6884
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03975.1"
                     /locus_tag="K2F47_RS09055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_242902308.1"
                     /sec_met_domain="TIGR03975 (E-value: 1.1e-180, bitscore:
                     598.8, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVLVNMPWGSTDVPSLALGILKRAVTEQIPGADVEVLYANIDF
                     VDWVHDRVDMAMEDYDFFAQRSFTEGNGDWVFSSALYDDPHWRRREFDERASGEQADLA
                     LCHRLHELAPAFVAELAGRVAASSPDVVGFTSTFQQNAAALAAARQIKRLRPETATILG
                     GASCDGPQGAALHRNFPFVDFVLRGEGETAFPRFLTALAGARDFAAIPGLVRRDGNGAS
                     IANAMSARPLSPSEIVAPDYDDYFRRYASSVARLWADPRLVLESSRGCWWGEKHHCSFC
                     GLNGSFMEFRSKPPGRFLDELLSLARRHQVLDVFMVDNILDMAYLTSMLPALAAEGYDF
                     RVFYEVKSNLRRSQVRTLADAGVVRVQAGIESLSGRVLDIMEKGVTGCQNVRMMRDAES
                     AGVWVEWNYLYGFPGESADDYTSVIEQFPALHHLPPPGMVGRLAIERFSPYFDRPEMGF
                     AELRPHSQYSMIYDLPESELFDLGYLFEAPPRGIGAAVAERLADAAAEWRSAYPESRLT
                     VCDLGDHIDLVNRRPAFDWTTLRVEDPVEVAALRLLDRPHRPAALTAKLAALDPAVTGD
                     DVADLLARWRGLGMLFADGGRVVLTAVDAAGQGLRRVNRRAGDAADLVGAP"
     gene            6881..7489
                     /locus_tag="K2F47_RS09060"
     CDS             6881..7489
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039872.4"
                     /locus_tag="K2F47_RS09060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5825 family protein"
                     /protein_id="WP_242902309.1"
                     /transl_table=11
                     /translation="MTPPVAMTLWRDYEELDRPGVCAGTTAVSGPAAEASQALFEDGVR
                     RVALDDLVDLSSASDVPTLVLVRELTAYGIAVDWRVRLDAGGWRDLSHLFPPGEVAGDE
                     EAHRGWRDGYHFFKCVYRRGPGFLQVRDRRSGVLRRITIDGPAHRAAVDDLLEGCPVSA
                     LPPAVLRDLATMRLVHLLDGTAWWLPCRVRQWPSGKSVL"
     misc_feature    7498..7511
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.88"
                     /tool="antismash"
     gene            7523..7699
                     /locus_tag="K2F47_RS09065"
     CDS             7523..7699
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS09065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242902310.1"
                     /transl_table=11
                     /translation="MTVNRPETTEGREEARAEALRAALAEMSTENLATTEGIRVDVVRD
                     DIDAPHERDWGIG"
     gene            7773..8939
                     /locus_tag="K2F47_RS09070"
     CDS             7773..8939
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K2F47_RS09070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242902311.1"
                     /transl_table=11
                     /translation="MTAAEPDAAVWDGVSTLLDHYLRIRADDRVVLLYTADARDPAAWV
                     AAELAVRGVAPALLGMSAGRDDTVEPRLRAALPDPASPHPRIVLLTMERDSMSHVLQLR
                     RALAPYPEDRWATYRVINASAEFFRHSMGVTPELLSALNGALLNRMMPASRLRVTSGGG
                     TDLEIAVDSERYRWISNRGVWRPGAFLVLPPGEVSTYPADVNGVLVADGAFNVTSYTGH
                     DVRLADHPVTVDIEHGRVAGVACADPLVARLLERCLRVENADRIGELGFGTNVGTTAFI
                     PLNSHINERHPGVHLGLGMHGQRLDVVDYWCDVHLDLITADATVVVDGRTEIRSADLAD
                     LACLAGERHPEPLTGNVHEEDIDGDCCGLITGEVARAREAFLRTRECR"
     gene            complement(8946..10253)
                     /gene="rfbH"
                     /locus_tag="K2F47_RS09075"
     CDS             complement(8946..10253)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rfbH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017571002.1"
                     /locus_tag="K2F47_RS09075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lipopolysaccharide biosynthesis protein RfbH"
                     /protein_id="WP_242902312.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 8.3e-96,
                     bitscore: 318.3, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMSDTQDSILDLVREYHREKEERRRFVPGETLVMPSGADLSEDDR
                     VALVEAALNLRIASGPSAVALERELGRTLRRRKVHLTNSGSSANLLALTALAQPEIGDD
                     RLRPGDEVVTVAAGFPTTVNPILQNQMVPVFVDVELGTYNTTADRVAEAIGPRTRGIMI
                     AHALGNPFPVAEVAELAKEHGLFFVEDNCDGVGASYQGRLTGTFGHFSTVSFYPAHHLT
                     MGEGGCVTTDRPKLARIVESLRDWGRDCWCEPGDCDTCGKRYTQRFGDLPYGYDHKYTF
                     SHVGYNLKTTDLQAALGLSQLQRLPEFGAARRRNWARLREGLDGLPGLLLPVPTPGGDP
                     SWFGFIITVDADAPFDRDEIVAHLEDRRIGTRMLFAGNLTRQPAYQGKEYRVSGKLDNS
                     DAITERTFWIGVFPGLTDEMVDYMITTIRDFVTSRR"
     gene            complement(10341..10796)
                     /locus_tag="K2F47_RS09080"
     CDS             complement(10341..10796)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012851748.1"
                     /locus_tag="K2F47_RS09080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cupin domain-containing protein"
                     /protein_id="WP_242902313.1"
                     /transl_table=11
                     /translation="MTDARARGNAAWHGRIEHVRGADLGSDTTQTSGMRRYEAISGKSV
                     GSERLWMGRTHVGPATNSGDHHHGEAETAIYIVSGHPVFVFADGDEEVRVETAPGDYIF
                     VPPYLPHREENPSPDEEAVVVIARSTQEGIVVNLPSLWADVERPTET"
     misc_feature    complement(10828..10841)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.05"
                     /tool="antismash"
     gene            complement(10830..11255)
                     /locus_tag="K2F47_RS09085"
     CDS             complement(10830..11255)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653747.1"
                     /locus_tag="K2F47_RS09085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_242902314.1"
                     /transl_table=11
                     /translation="MSTRPRLPDDVEPDACAAFRDALDRVGSKWGIAIIAAAGDGPIRF
                     AELHRSIPGISRRMLTLTLRTLERDGLIVRTVHPTVPPQVEYTATALATELFASTRALS
                     AWAENNHAKIAAARAAYDDNAAARHDDRRPVDDPNLY"
     misc_feature    complement(11457..11471)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
ORIGIN
        1 gcccgcgagg cccacgtgat cgtgatggag cggctcggca ccggcgtgat cctcaaggac
       61 accgccgacg aaccggaggc gtggcgcccg cggcacgtcg ccgcagccct ccggggcatc
      121 gcggccgtgc acgcggcctg gctcggccgg gacgaggagg tccgcggctg gctcggcgcc
      181 gcccggacgg ccgagagcat gacggccatg cgggagctgt ggtcggcgca cctggagcac
      241 agcgccgccg agcaccccga cctgctggac gcctgcgccg cgcgacggct ggaggacgtc
      301 ctggacgggc tgccggactg gtggcgccgg atggaggcga tgccgcgcac gctcgtccac
      361 aacgacttca acccgcgcaa catcgccctg cgcgccgccg acctgagcct ggtcgcctac
      421 gactgggagc tcgcgacgct ccacgtcccg cagcgcgacc tggccgagct cctcgcgttc
      481 gtgctctccc cggaggcgac ggaggcggac gtgaccgcct acctcgacct gcaccgggag
      541 gccgtcgggg ccgggatcga cccgggcgcc tggcgggacg ggtaccgcct cgccctgtgg
      601 gacttcgccc tcacgcggct ccagatgtac ctgatggtgc acacccaccg cgagctgccg
      661 ttcctgcggc acgtcgtccc gaccaccctg cgcctgatcg agatcgagga cgccgtggag
      721 gaggcgggcc gtgccgactg accgtcccaa tccgctgcgg ctggcgatcc tcggcatcga
      781 cggctcgggc aagagcacgg tcgcccggtg cctcgccgag cgggctctcg tcggcgggcg
      841 gcacgccgtg ctgtcgtgtg tgcgccccca cgagaacccc gacgcgccgc tgcacgagct
      901 gtcgcggcac ctcgacgtcc tgtcgaagga ggccgaccgg ctcggcagcc cggagctgaa
      961 gctggccgtc ctctacctcc agatgtgcac ctacggggtc ggcgagcggt tcgtcacccg
     1021 cgagctcggg gtggacgtcg tcgtcagcga gcgccacccc gtcatcgacg cgctcgccta
     1081 cctgccgctg taccggagcg cgatcgtgcg ggcggccggg cccgggcgcg cggacgccgt
     1141 ccgcgcgaag ctggccgcgc tgcccgccga gtccgtcgag gccgcggccg cctggtgcga
     1201 ggcgctcgga cgccggtccg cgcggcccgc gccgaagctg gagacgctcg ccggcgagct
     1261 ggtcgcgctg gcgggccgtc cggcggccga gcagatcgcc gagttccgag tgcggttcgg
     1321 gaccggcctg cccgacatcg ccgtcctgct cgacgtcgcg gtcgagacgg ccgccgaccg
     1381 gatcggcgcc cgcgaccgcc gcgccgagca gcacgaacgc cccgaccggc tcatccggct
     1441 ccgcgacggg tacgaccggg cgctgcccgc attcggcgcg gtggcgctcc accggatcca
     1501 ggtcggcgcc cgcccgccgg gggacgtcgc cgccgagatc gcgcggctcg tcaccgccgg
     1561 ggcgcgatga ccgggccgtc gcgggaggtg ctcggcgcgg catgggacgc ccgcatggaa
     1621 cgcgtccgcc tcgcgtcgcg cgagctgcgc gggccgctgc cgcgcacggc cgccgtcgcc
     1681 gtcctgcggg agttcacccc gcgcgcgttc ctcggttcgg cggtcgcctt cgcccgcggg
     1741 ctgcccccgg cccggcgcgc cgcctggtac gcgagctaca gcaggacgat cttcctcgcg
     1801 ggcgaccccg gcaacctcgc cgggcgccac ccctgcgacc acctgtccgg cgacgggtcc
     1861 atcgcctggt acgaccccgc ccccatgacg gaacgcgagg ggttgcggcg gctgctcagg
     1921 cccttccgcg gtccggtcgg catcgtcggc ccggccgagg aggagctccc gatcggcgaa
     1981 ggggacgggg tcgcgcgcct ggacgtcccc gtggccgacc tgtcggtcga ggactacctc
     2041 gtcaacgtca accacctcct cgcagaggcg gtcatggacg ggcttctcac cggggtcggg
     2101 cgcctgctcg tccggcatct tccacgcgat tccgaggtgc ccgcccggtg cgatcggata
     2161 cgggtctcgg tcggggacgg gacggcgggc acgctccgcg cccacgccta cctgacgctg
     2221 accccgtagc gccgaaggcg aattcggggc gaagccgtgg ccgattccgt gggtcacctg
     2281 cttgctaaag ttggcgacta ccgattgcgg acagcctcct gggggagtcg gacgcccgcg
     2341 cccggcgcgg gagtgacgaa gggggaccgg gaaccgtgag cgcgccgctc taccagctga
     2401 aggcggagtt cttcaagacg ctcgggcacc cggcccggat ccgcgtgctg gagctgctca
     2461 gcgagcgcga ccacgcggtg gccgagatga tccccgaggt ggggatcgag cccgcgcacc
     2521 tgtcccagca gctcgccgtg ctgcgccgcg ccgggctcgt cgccgcccgc aaggagggcg
     2581 cgaccgtcat ctactcgctc accagccccc gcgtcgcgga actgctggcg gtcgcgcgcg
     2641 ccatcctgac cggcgtgctg tcggggcagg ccgagctgtt ggacgacctg cgcgcctccg
     2701 gcgtcaccgc cgaggggccc caccgctcct aggggaatcc ctacgcacga aaccgaggac
     2761 cccttcgcgc ccgacttata gcgaattgct aaccttggca attgcgcagg gcggtatccc
     2821 tcctgcgggt cggggccgtc tcccacggcg ccctatctct cactgaggaa cagcgtgaaa
     2881 gatctgctgc gcagaatccg gaggaccggc cggggcgcgg aggcaccgcc cgccccccgc
     2941 gcggccgcgg cgccgccgtg cgcccgcgcg ctcgacgcgt cggtgcgcgt ccggcacgtg
     3001 gacgcgggct cgtgcaacgg gtgcgaggtg gagatcgcct cggcgttcgg ccccgtctac
     3061 gacgccgggc gctacggggt gcggcaggcg gcctcgcccg agcacgccga cgcgctgctg
     3121 gtgaccgggc ccgtgacccg caacatggag gcggcgctgc gccgggcgta cgaggccgtg
     3181 cccgagccga aggtcgtggt ggcgctcggg gactgcgccc gcgaccgcgg tgtgttcgcc
     3241 gaggcgtacg gggtggccgg tgccgtgggc gacgtcgtcc cggtggacgt cgaggtgccc
     3301 ggctgcccgc cggaaccgga ggcgatcgtg gccgcgctgc gggggctcac cggccgatga
     3361 gcccgacggg cgccgcgccc acggcggcgc cgcccttgga gcgcaccgat gaaccctgag
     3421 gacagagccg atatcagcgc cgacgcgctc cccggacggg ccgccgccct gctcgaaggg
     3481 gcgcccgcct ggcgctggtc gccgcccacc aggacccgga cgcgctgcgg gtggtgtacc
     3541 tgttcacccg gaccgggccc gaccgccgca cggagctgca cgtccggctc gaccccgacg
     3601 cgccggtggt gccgagcctg gcccgcgcca gcgtcccggc gggccggttc gagcgcgaga
     3661 tgcacgacct gtacggcatc gtcccgcgcg accatccgca gcccgggacg ctggtccgcc
     3721 accgccactg gccgagcggc tggtacccga tgcgggagga cgccgggtcg ccgcccgagt
     3781 tcggcgaccc cgaggtcccg gccgggcccg tgcccgccgg gctcaccgga cccgggcatt
     3841 tcggcttctg tgtcgccggg gagagcatcc gcaaggtgga ggcccggccg gggttcgtcc
     3901 acaaggggat cgagaggctg ttccagggcc gcgatcccgc cgccgtcgtg ccgctcgccg
     3961 agcgcgtcag cggcgacacc gccgtcgggc acacgctggc gttctgcctg gccgtcgagg
     4021 aggccgccgg ggtgcgcgtc gcgccgggca cccagcgcgc gcgggcgctc ctgctggagc
     4081 tcgaacggct ctacaaccac gtcaccgacc tcggcgcgct gtgcgacgag atcggcgacc
     4141 aggtcctgag cgcgcggttc ggccgcgtcc gggagcagct gctgcggctc aacgcgcgga
     4201 tcaccgggca ccggctgctg cgcggcggcg tccggctcgg cggcgtgctg ctgcgcgcgc
     4261 tccccgaccc ggggacgctc gcggccgtcg gcgcggatct cgccgaactc gccgacctgg
     4321 cgctcggccg caccgcggtc gccgaccggc tcaccggcac cgcgccgctg gccgccggcg
     4381 ccgcgcgcga cctcggcgcc ctcggctacg tggcccgcgc cagcggcctg gacgccgacg
     4441 cccgccgcga ccacccgttc accgacctgc gaccggcgct gaccgtcccg accgcaggga
     4501 ccggtgatgt actcgcccgc ttccagatca gggcccgcga gatcgccgcg tccatcgcga
     4561 tcatcgttga cctgacctac gggctgggcc cgggctcggc ggtctactgg ccgccgctcg
     4621 ccccgccgga cggcccggcc tccggcgtcg ggatcgtgga gggctggcgc ggcacgatcg
     4681 tgcaccgggt cgaactcgcc cccggcggca cgctcacccg taccaagatc gtcgatccgt
     4741 cgttcttcaa ctggcccgcg ctgccggtgg cgctggaggg cgcgctcgtc cccgacctcc
     4801 cgctggtcga ccggagcttc aacctctccc acgccggcaa cgacctgtag cgcgggacgg
     4861 ggacgccgaa ccgggctcgg ccgcgagtaa ctctccgtag cggacgtgtc cacctacgga
     4921 cggcgccttg ccgggcccgg cggcccggcg gaccatgggc gtgacgccgg gatcgtggcc
     4981 gcacccccga ggggagcacg atgcgggtag ttctcgtcaa catgccgtgg ggctccaccg
     5041 acgttccctc gctggccctg gggattctca aacgcgcggt gacggaacag atccccgggg
     5101 ccgatgtcga ggtgctgtac gccaacatcg acttcgtcga ctgggtccac gaccgcgtcg
     5161 acatggcgat ggaggactac gacttcttcg cccagcggtc cttcaccgag gggaacggcg
     5221 actgggtctt ctcctcggcg ctctacgacg atccgcactg gcggcggcgc gagttcgacg
     5281 agcgggcgag cggcgagcag gccgacctgg ccctgtgcca ccggctgcac gagctggcgc
     5341 ccgcgttcgt cgcggagctc gccggacgcg tcgccgcgtc gtcacccgac gtcgtcggct
     5401 tcacctccac gttccagcag aacgccgccg cgctcgcggc ggcccggcag atcaagcggc
     5461 tccggccgga gaccgcgacg atcctcggcg gggcgagctg cgacgggccg cagggcgccg
     5521 cgctgcaccg caacttcccg ttcgtcgact tcgtgctgcg aggcgagggc gagaccgcct
     5581 ttccccggtt cctcaccgcc ctggctggcg cgcgcgactt cgcggcgatc cccggcctcg
     5641 tccggcggga cgggaacgga gcctcgatcg ccaacgcgat gagcgcccgc ccgctgtcgc
     5701 cgagcgagat cgtcgccccc gactacgacg actacttccg gcggtacgcc tcgtccgtcg
     5761 cgcggctgtg ggccgacccg cggctcgtcc tggagagctc gcgcggctgc tggtggggcg
     5821 agaagcacca ttgctcgttc tgcggcctga acgggtcgtt catggagttc cgcagcaagc
     5881 cgccggggcg cttcctcgac gagctgctct ccctcgcccg gcggcaccag gtgctcgacg
     5941 tgttcatggt cgacaacatc ctcgacatgg cgtacctgac gtcgatgctc cccgcgctcg
     6001 ccgccgaggg ctacgacttc cgcgtcttct acgaggtgaa gtccaatctg cggcgaagcc
     6061 aggtgcgcac gctggccgac gcgggagtcg tgcgggtgca ggcgggcatc gagagcctca
     6121 gcggccgcgt cctcgacatc atggaaaagg gcgtgaccgg ctgccagaac gtccggatga
     6181 tgcgcgacgc cgaatcggcc ggtgtctggg tggagtggaa ctacctctac ggttttccgg
     6241 gggagagcgc cgacgactac acctccgtca tcgagcagtt ccccgcgctg caccacctgc
     6301 cgccgcccgg catggtcggc aggctcgcga tcgagcggtt cagcccgtac ttcgaccggc
     6361 ccgagatggg gttcgccgaa ctgcggcccc attcccagta ctcgatgatc tacgacctgc
     6421 ccgagtcgga gctgttcgac ctcggctacc tgttcgaggc gccgccgcgc ggaatcgggg
     6481 cggcggtcgc cgaacggctc gccgatgccg ccgccgaatg gcggtcggcc tatccggaga
     6541 gccggttgac cgtgtgcgac ctcggcgacc acatcgacct ggtgaaccgg cgtcccgcct
     6601 tcgactggac cacactgcgg gtcgaggacc ccgtcgaggt ggccgccctg cgcctgctcg
     6661 accggccgca ccgtccggcc gcgctgaccg cgaagctcgc cgcgctggac ccggccgtca
     6721 ccggcgacga cgtcgcggac ctgctcgcgc gctggcgcgg cctcgggatg ctcttcgccg
     6781 acggcggccg ggtcgtactg accgccgtcg acgcggccgg ccagggcctg cgccgggtga
     6841 accggcgcgc cggcgacgcg gcggacctgg tcggagcgcc gtgacgcccc cggtcgcgat
     6901 gacgctgtgg cgcgactacg aggagctcga ccggccgggc gtgtgcgccg ggaccacagc
     6961 cgtctccggt cccgcggccg aggcgagcca agcccttttc gaggacgggg tgcgccgcgt
     7021 cgcgctcgac gacctggtgg acctgtcgag cgcgagcgac gtcccgaccc tcgtactggt
     7081 aagagagttg accgcttatg gaatcgccgt cgactggcgg gtgcgcctgg acgccggggg
     7141 atggcgggat ctgagccacc tctttccgcc cggcgaggtc gccggcgacg aggaggccca
     7201 ccgcggctgg cgggacggat accacttctt caaatgcgtc taccgccgcg ggccgggatt
     7261 cctccaggtg cgggaccggc gttcgggtgt gctgcgcaga atcaccatcg acggcccggc
     7321 gcatcgcgcg gcggtcgacg acctgcttga gggctgcccg gtttccgcgc tcccgcccgc
     7381 ggtcctgcgc gacctggcca cgatgaggct cgtccatctc ctcgatggaa cggcctggtg
     7441 gctgccctgc cgggtgcggc aatggccctc cggaaagagc gttctgtgat ccgtggaatt
     7501 gttcggagaa acgaggtgcg gcatgaccgt gaacagaccc gagacgaccg aggggcgtga
     7561 ggaggcccgc gcggaggccc tgcgcgccgc gctcgcggag atgagcacgg agaacctggc
     7621 cacgaccgag ggcatccgcg tggacgtcgt ccgcgacgac atcgacgccc cgcacgaacg
     7681 ggactggggc atcggctgac cgcgggcgcc ccgcccgccc cgggtgccgc ccgccgggcg
     7741 gcacccggag acccgcaccg gaggcgatga cgatgacggc agccgaaccc gatgccgccg
     7801 tgtgggacgg cgtgtccacc ctgctcgacc actacctccg gatccgcgcc gacgaccggg
     7861 tcgtcctcct ctacacggcg gacgcgcggg acccggccgc gtgggtcgcc gccgagctgg
     7921 ccgtccgcgg cgtcgcgccg gcgctgctcg ggatgagcgc gggccgcgac gacacggtgg
     7981 agccccggct gcgcgcggcg ctgcccgacc ccgcgtcccc gcatccgcgg atcgtgctgc
     8041 tgacgatgga gcgcgactcg atgtcgcacg tgctccagct ccgccgggcc ctcgccccct
     8101 accccgagga ccgctgggcg acctaccggg tcatcaacgc ctcggcggag ttcttccgcc
     8161 actcgatggg cgtcacgccg gagctgctgt cggcgctcaa cggcgcgctg ctgaaccgga
     8221 tgatgcccgc ctcccgcctg cgggtcacct ccggcggcgg caccgacctg gagatcgccg
     8281 tcgactccga gcggtaccgg tggatcagca accggggcgt gtggcggccg ggcgcgttcc
     8341 tcgtcctgcc gccgggggag gtcagcacgt acccggcgga cgtcaacggc gtcctcgtcg
     8401 ccgacggtgc cttcaacgtg acctcctaca ccggccacga cgtccggctc gccgatcatc
     8461 cggtgaccgt cgacatcgag cacggccggg tcgccggcgt cgcctgcgcc gacccgctcg
     8521 tggcccggct gctggagcgc tgcctgcggg tcgagaacgc cgaccggatc ggggagctcg
     8581 gcttcggcac caacgtcggc accaccgcgt tcatccccct gaactcccac atcaacgagc
     8641 gccacccggg cgtgcacctc ggcctcggca tgcacgggca gcggctggac gtggtcgact
     8701 actggtgcga cgtccacctc gacctcatca ccgcggacgc gaccgtcgtc gtcgacggcc
     8761 gcaccgagat caggagcgcc gacctcgccg atctcgcctg cctcgccggt gagcggcatc
     8821 ccgagccgct caccgggaac gtccacgagg aggacatcga cggcgactgc tgcggcctca
     8881 tcaccggcga ggtcgcccgc gcgagggagg cgttcctccg gacgcgggag tgccggtgag
     8941 ccgggctacc gccggctcgt gacgaagtcc cggatcgtgg tgatcatgta gtcgaccatc
     9001 tcgtcggtga ggccggggaa gacgccgatc cagaaggtgc gctcggtgat cgcgtcgctg
     9061 ttgtcgagct tgcccgagac ccggtactcc ttgccctggt aggcgggctg gcgggtcagg
     9121 ttgcccgcga acagcatgcg ggtgccgatc cgccggtcct ccaggtgggc gacgatctcg
     9181 tcccggtcga acggcgcgtc ggcgtcgacc gtgatgatga acccgaacca gctcgggtcg
     9241 ccgcccggag tcgggacggg caggagcagg ccgggcaggc cgtccaggcc ctcgcgcagc
     9301 cgcgcccagt tgcggcggcg ggccgcgccg aactccggca gccgctggag ctgggagagc
     9361 ccgagcgccg cttgcaggtc ggtcgtcttg aggttgtagc cgacgtggga gaacgtgtac
     9421 ttgtggtcgt agccgtaggg caggtcgccg aaccgctgcg tgtagcgctt gccgcaggtg
     9481 tcgcagtcgc cgggctcgca ccagcagtcg cgtccccagt cgcgtagcga ctccacgatc
     9541 cgcgccagct tcggccggtc ggtggtcacg cacccgccct cacccatcgt cagatggtgg
     9601 gcgggataga agctcacggt gctgaagtgg ccgaacgtcc cggtcaggcg gccctggtag
     9661 ctcgcgccga cgccgtcgca gttgtcctcg acgaagaaca ggccgtgctc cttggccagc
     9721 tcggcgacct cggcgaccgg gaacgggttg cccagcgcgt gcgcgatcat gatgccgcgg
     9781 gtgcgcgggc cgatcgcctc ggcgacgcgg tcggcggtgg tgttgtaggt gccgagctcc
     9841 acgtccacga agaccgggac catctggttc tggaggatcg ggttgaccgt cgtcgggaag
     9901 cccgccgcca ccgtcacgac ctcgtcgccc ggacgcagcc ggtcgtcacc gatctccggc
     9961 tgggccagcg cggtcagcgc cagcaggttc gccgacgacc ccgagttcgt caggtgcacc
    10021 ttgcggcgcc gcagcgtccg cccgagctcg cgctccagcg cgaccgcgct cggcccggac
    10081 gcgatgcgca ggttcagcgc ggcctcgacc agcgcgacgc ggtcgtcctc gctcaggtcg
    10141 gcgccggacg gcatcaccag cgtctcgccg gggacgaacc gccgtcgctc ctccttctcg
    10201 cggtggtact cgcggaccag gtccaggatc gagtcctggg tgtcactcat catcgcctcc
    10261 agggcgcgcc acggcgcgga cccggtccat caaaacagcg ggacgcggga tctcctcccc
    10321 tgtgggcccc ccttagtgac tcaggtctcg gtggggcgct cgacgtccgc ccagaggctc
    10381 gggaggttga ccacgatgcc ctcctgcgtg ctgcgcgcga tgaccacgac cgcctcctcg
    10441 tcgggggacg ggttctcctc gcggtgcggg aggtagggcg ggacgaagat gtagtcgccc
    10501 ggcgcggtct ccacccggac ctcctcgtcg ccgtcggcga acacgaacac cgggtgcccg
    10561 gagacgatgt agatcgcggt ctccgcctcg ccgtggtggt ggtcgcccga gttggtcgcg
    10621 gggccgacgt gcgtgcggcc catccagagc cgctccgagc cgacgctctt gcccgagatc
    10681 gcctcgtacc ggcgcatccc cgacgtctgg gtggtgtcgg agccgaggtc ggcaccgcgc
    10741 acatgctcga tccgcccgtg ccaggcggcg tttccccgtg cgcgcgcgtc agtcacgttc
    10801 gtcccccaat gtcatgaatt ttggctgttt tagtagagat tggggtcgtc gacgggccgc
    10861 cggtcgtcgt gccgcgcggc cgcgttgtcg tcgtaggcgg cgcgcgccgc cgcgatcttc
    10921 gcgtggttgt tctccgccca cgccgacagc gcccgggtgg aggcgaacag ctccgtggcg
    10981 agggccgtgg cggtgtactc gacctgcggc gggacggtcg ggtggacggt gcggacgatc
    11041 agcccgtccc gctccagcgt gcgcagcgtg agcgtcagca tgcggcggct gatgcccggg
    11101 atcgagcggt gcagctcggc gaagcggatc gggccgtcgc cggccgccgc gatgatcgcg
    11161 attccccact tgctcccgac ccggtcgagg gcgtcgcgga aggccgcgca cgcgtcgggc
    11221 tcgacgtcgt cgggcagccg aggtcgtgtg gacatcgaac tcccctcccg gtgcggacgt
    11281 ttcagcctta caccgatcgt ccgcaccggc aacctgtccc gcgcgcgggt cagggcggcg
    11341 ggtcggggag ggacgtgcgc agcgccggcg cgacctcggt ggcgaacagt tcgagggacg
    11401 tccagtggtc gtccagcggc agcccgtcgg gatcgacgct gaacacggcg agcgagtggc
    11461 cgaagatctc gtgctgccgg tgcaccttgt cgatcacctg ctcggggctg ccgacgagcg
    11521 ccggcgagtg cgcgacgaac tcctccacgc tcgcgaaggg cgggcgcccg ccgatgctcc
    11581 gctgcatcgc ggcgaggcgc tcgaaggcgg gccggtacgc ggcgagcgcc gcctgcgagg
    11641 tcttggcgac gaggaagccg ggcgtcccgg cgccggtgaa gagccggtcg gcgggacggc
    11701 cgtgccgggc ccacgcggcg cggtagtact cgaccagcgg gcgcgcgctc tcgctggaca
    11761 ggcccgcgtt ggagaacacc acgggatcgc cgtactcggc ggccagctcc agggactccg
    11821 ccgaggacga gctgccgtgc cagatccggg ggcggccgtt cagcggccgg gggaggaggt
    11881 ggaa
//
