LOCUS       NZ_JALDPQ010000067     11392 bp    DNA     linear   CON 28-MAY-2024
DEFINITION  Streptomyces sp. TRM75563 738, whole genome shotgun sequence.
ACCESSION   NZ_JALDPQ010000067
VERSION     NZ_JALDPQ010000067.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TRM75563
  ORGANISM  Streptomyces sp. TRM75563
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 804357)
  AUTHORS   Chen,Y.
  TITLE     Streptomyces aheensis sp. nov., isolated from road
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 804357)
  AUTHORS   Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2022) College of Life Science, Tarim University,
            Hongqiao, Alar 843300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 14-MAR-2022
            Assembly Method                   :: ABySS v. V2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022748615.1-RS_2024_05_28
            Annotation Date                   :: 05/28/2024 05:18:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,476
            CDSs (total)                      :: 7,413
            Genes (coding)                    :: 7,165
            CDSs (with protein)               :: 7,165
            Genes (RNA)                       :: 63
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 249
            CDSs (without protein)            :: 248
            Pseudo Genes (ambiguous residues) :: 1 of 249
            Pseudo Genes (frameshifted)       :: 108 of 249
            Pseudo Genes (incomplete)         :: 202 of 249
            Pseudo Genes (internal stop)      :: 19 of 249
            Pseudo Genes (multiple problems)  :: 75 of 249
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:22:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 338336
            Orig. end                         :: 349728
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALDPQ010000067.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11392
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11392
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11392
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6392](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6392)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(331..345)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    358..373
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.22"
                     /tool="antismash"
     gene            1336..2064
                     /gene="hemQ"
                     /locus_tag="MQC87_RS34010"
                     /old_locus_tag="MQC87_34010"
     CDS             1336..2064
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965515.1"
                     /locus_tag="MQC87_RS34010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_34010"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_103510299.1"
                     /transl_table=11
                     /translation="MSAPETATSSKSPNAGKKAKDLNEVIRYTLWSVFKLRDVLPLDRA
                     GYADEVQELFDQLAAKDITVRGTYDLSGLRADADLMIWWHAETSDQLQDAYNLFRRTKL
                     GRALDPVWSNMALHRPAEFNKSHIPAFLADETPRDYISVYPFVRSYDWYLLPDEDRRRM
                     LADHGKMARGYPDVRANTVASFSLGDYEWILAFEADELYRIVDLMRHLRASEARLHVRE
                     EVPFYTGRRKSVADLVAGLA"
     gene            complement(2219..3781)
                     /locus_tag="MQC87_RS34015"
                     /old_locus_tag="MQC87_34015"
     CDS             complement(2219..3781)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (101-476). E-value:
                     4.4e-18. Score: 57.7. Matches aSDomain:
                     nrpspksdomains_MQC87_RS34015_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956907.1"
                     /locus_tag="MQC87_RS34015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_34015"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_103510300.1"
                     /sec_met_domain="PF00561 (E-value: 1.8e-24, bitscore: 82.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTAALYTSIGSLVLSALAAAPANAWEAPGSAEARGTAIAAARAT
                     AAGIDFAACPEEEMLPDSLKCGTVKVPLDYAEPDGRQLELTVSRTPATGPPKERQGAFV
                     YNPGGPGASSITFPLAGELPEWKEIAEAYDLVGYAPRGVNGSSDPLSCQDPAAYTKGPT
                     DAPTHPTQAYKERRVARAKAYAQGCAEHAGATLRHYTSLNNARDLDVLRAALGESRLTF
                     MGASYGTYFGALYATLFPSHVRRMVFDSVVDPDPEQIWYRSNMDQSLAFETRWEDFRRW
                     VARHDDVYHLGATPEAVQKHYDEVRAELAVKPAGGTVGPGQLHSAFLGAGYYDDYWAMR
                     ATALSEYVRGNPEPLVAQASPRAVAAKDNENAQAVYTAVECNDAPWPEEFEVWDRDHTD
                     LARVAPFETWDNAFTNLPCAFWPAPRQRPLEVGTRWGELPPALILAAERDAATPYKGAL
                     ELRKRLPGSSLVTERGAGTHGIGGAGNTCVDDHLRRYLLTGEVPGRGADCAAHPEPNPV
                     SLD"
     aSDomain        complement(2354..3478)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MQC87_RS34015_Abhydrolase_1.1"
                     /evalue="4.40E-18"
                     /label="MQC87_RS34015_Abhydrolase_1.1"
                     /locus_tag="MQC87_RS34015"
                     /protein_end="476"
                     /protein_start="101"
                     /score="57.7"
                     /tool="antismash"
                     /translation="AFVYNPGGPGASSITFPLAGELPEWKEIAEAYDLVGYAPRGVNGS
                     SDPLSCQDPAAYTKGPTDAPTHPTQAYKERRVARAKAYAQGCAEHAGATLRHYTSLNNA
                     RDLDVLRAALGESRLTFMGASYGTYFGALYATLFPSHVRRMVFDSVVDPDPEQIWYRSN
                     MDQSLAFETRWEDFRRWVARHDDVYHLGATPEAVQKHYDEVRAELAVKPAGGTVGPGQL
                     HSAFLGAGYYDDYWAMRATALSEYVRGNPEPLVAQASPRAVAAKDNENAQAVYTAVECN
                     DAPWPEEFEVWDRDHTDLARVAPFETWDNAFTNLPCAFWPAPRQRPLEVGTRWGELPPA
                     LILAAERDAATPYKGALELRKRLPGSSLVTERGAG"
     gene            complement(3946..4995)
                     /locus_tag="MQC87_RS34020"
                     /old_locus_tag="MQC87_34020"
     CDS             complement(3946..4995)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514514.1"
                     /locus_tag="MQC87_RS34020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_34020"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_242743155.1"
                     /transl_table=11
                     /translation="MNVFALLATLGIVVSSVLLVVKAVAERSRRPAPGPGVALHDLYEV
                     AFLNGGPARVVDTALTALHADGRLAVGGPGIVAVRWAQANDPVERAVFQELAAAPSGAL
                     HVLRERVMRHPAVQEVGDGLAARGLLVPPHRVRPLRRWGLIQGVACLIALPLSLVVTFV
                     QLAVVDTMDFPVPFIVKVLPAIVIGAFTGLIVAGTSASRITKSGQHAALAFRAAYAHVV
                     TPAHLVATLGLRALPDPVFQAQLVAAARLSAPRRRSSSYVTGSTAAGVTAVGVATVWCA
                     ASSPGGSSCGGSTGGGSGSSCGGGSGCSSGSGCSSGSGCGGSSGSSCGSSGGSSCGGGG
                     GGSSCGGGS"
     gene            complement(5001..6392)
                     /locus_tag="MQC87_RS34025"
                     /old_locus_tag="MQC87_34025"
     CDS             complement(5001..6392)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018100703.1"
                     /locus_tag="MQC87_RS34025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_34025"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_242742853.1"
                     /sec_met_domain="DUF692 (E-value: 1.4e-92, bitscore: 305.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELGIGIGWRPEIADEVEALAGIDWVEAVAENLCADHLPDSLVRL
                     RERGVTVVPHGVALGLGGADRPDPGRLASLAARAELLGTPLVTEHIAFVRAGGPLTASP
                     RLEAGHLLPVPRTWDALDVLCENVRIAQDSLPVPLALENIAALISWPGEELTEGQFLAE
                     LVERTGVRLLIDVANLHTNHVNLGQDPAKALDELPVEAIAYVHVAGGVEKNGVWHDTHA
                     HPVSEPVLEVLAELRSRVDPPGVLLERDDAFPPGAELAGELDAIRATLRRAATVRVPAA
                     AGERTGVADPVSAGAGERTSTAGAGERTGVADPAPAEGRAVADPVPAGTRDRTAVAQTA
                     LLSALVAGTPAPEGFDHRRLRVQSRALAAKRADVVAKVAPELPEILGDGYRAGFLAYAG
                     SRPMSGGYRRDALDFAEHVLIAGGPADPAARRRLTYWWQDRSGARPPGRATRLVRAARA
                     VLVGK"
     gene            complement(6522..7268)
                     /locus_tag="MQC87_RS34030"
                     /old_locus_tag="MQC87_34030"
     CDS             complement(6522..7268)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072530.1"
                     /locus_tag="MQC87_RS34030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_34030"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_181010952.1"
                     /transl_table=11
                     /translation="MRRINGTALIIAALVATIGALAFPVWSYADRSGTGEANLNASSVA
                     TQWGPLSATDRDFLVKVRLAGLWELPAGQQAIERAPSEATKAAGDHLVVGHADLDRRAR
                     DVAAKLGVELPNQPTAQQQEWLRELTAASGDEYERKFANILRAAHGKVFGLIGQVRHTT
                     RNTLIRQLASDANQTVLDHITMLEATGFVDFDALAREAASGSTASPSGPSMPRDGQVPL
                     APVPATPTGDQSFTSRPVPPTMMPMP"
     gene            complement(7483..8205)
                     /locus_tag="MQC87_RS34035"
                     /old_locus_tag="MQC87_34035"
     CDS             complement(7483..8205)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072531.1"
                     /locus_tag="MQC87_RS34035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_34035"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_098027260.1"
                     /transl_table=11
                     /translation="MTSNDTPVSESPFHNGPTDRDQAPQFVLPLVLHLEKTDPPARTDA
                     LRTAARAVLTILSDERSLGDGEWAAAMRDWQDARIRKVVRRARGAEWRKAAALDGITVT
                     GEDGAEVRVFPPIPLDGWPKELAKLQVSGTDLEDPEPPAAPDLSGPVLWLNPEVDMSAG
                     KTMAQAGHGAQLAWWELSDAERKAWREAGFPLSVATPGAERWRELTVSGLPVVRDAGFT
                     EIAPGSCTVVADHPALRR"
     misc_feature    complement(8165..8180)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.4"
                     /tool="antismash"
     gene            8276..8950
                     /locus_tag="MQC87_RS34040"
                     /old_locus_tag="MQC87_34040"
     CDS             8276..8950
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378552.1"
                     /locus_tag="MQC87_RS34040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_34040"
                     /product="AIM24 family protein"
                     /protein_id="WP_242742854.1"
                     /transl_table=11
                     /translation="MKSDLFSSEHMAQPATAPGMTLQNSKSIKYAVNGEMHARQGSMIA
                     FRGNLQFERKGQGIGGLLKRAVTGEGLALMAVRGQGEAWFAHEAANCFIVELDQGDSIT
                     INGRNVLCFDPTLSYEIKTVKGAGMVGGGLFNSVFTGHGKLGLMCEGTPIVIPVTAAQP
                     VYVDTDAVVGWSQQLATSLNRSQSVGSMVRGGSGEAVQLMLQGEGFVIVRPSEARPEKT
                     SN"
     gene            8953..>9215
                     /locus_tag="MQC87_RS34045"
                     /old_locus_tag="MQC87_34045"
                     /pseudo=""
     CDS             8953..>9215
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018852476.1"
                     /locus_tag="MQC87_RS34045"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="MQC87_34045"
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHLEGVGHRYGLRGAWVLRGVDLVLPARALVRVEGANGVGKPTLL
                     RLLAGIDAPPRDGSPAARPVRHTSPSASRLRCR"
     gene            9249..9917
                     /locus_tag="MQC87_RS34050"
                     /old_locus_tag="MQC87_34050"
     CDS             9249..9917
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452202.1"
                     /locus_tag="MQC87_RS34050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_34050"
                     /product="ABC transporter"
                     /protein_id="WP_242743156.1"
                     /transl_table=11
                     /translation="MTALLRYQTGLLAPSQRWLAPLLLYAAVLAVGLRGGQPVLGSLGV
                     AAAALLPVTAWAVHLCVTQEPPAARTVASAAVGPGRVHLSALLAATGCAAALAVVSTAV
                     VLLVSSPATDDGAHAVSGPSAALAGRTAALCCVLLGAVVGALSSRPVTVRRGWSVAAAV
                     LGSLLALVTTGSPARHAVTALVTGSRTGMFQPPGLPLLGAAVLAGSVTAAVCRLAARRG
                     "
     gene            9927..10151
                     /locus_tag="MQC87_RS34055"
                     /old_locus_tag="MQC87_34055"
     CDS             9927..10151
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059396.1"
                     /locus_tag="MQC87_RS34055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_34055"
                     /product="hypothetical protein"
                     /protein_id="WP_242742855.1"
                     /transl_table=11
                     /translation="MSRLVDVDTDDTDNTYCEAPGPIAPAPPAGAAEGPPYAECVLCRE
                     PTEYPESTKGATLCPVCAWQEAGRTACSG"
     gene            complement(10229..10936)
                     /locus_tag="MQC87_RS34060"
                     /old_locus_tag="MQC87_34060"
     CDS             complement(10229..10936)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015609271.1"
                     /locus_tag="MQC87_RS34060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_34060"
                     /product="AAA family ATPase"
                     /protein_id="WP_242742856.1"
                     /transl_table=11
                     /translation="MIIERAYAHVASYDRSEWPWSVPCVRQLLEEGLRITAPVTFLVGE
                     NGSGKSTLVEAIAEGFGLDSWGGSHDWRYASHRPKSVLGERIRLDATAYGRRMMGSWSA
                     RKGFFLRAETALDALDREGFAPDSVSHGEGFLAAFRGTFFRPGLYVMDEPEAALSFSSC
                     LELLGHIDQLVKNGGQVICATHSPLLTAFPGADIVEIGEHGMRRVAWSDLALVDHWRRY
                     LADPQSYLRHVLG"
     gene            complement(10933..11076)
                     /locus_tag="MQC87_RS34065"
                     /old_locus_tag="MQC87_34065"
     CDS             complement(10933..11076)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MQC87_RS34065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MQC87_34065"
                     /product="hypothetical protein"
                     /protein_id="WP_242742857.1"
                     /transl_table=11
                     /translation="MAITVPIVMAAPLALLPAPLARSGRRSGPVRTGDRGLLSAPSGRL
                     TP"
     misc_feature    complement(11374..11389)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.18"
                     /tool="antismash"
ORIGIN
        1 accggctcgg cggcaagctc atgaccgggg agatcgcggg cgtccaggtc gacctgggag
       61 ccgagtcgat gctcgcccgg cgccccgagg cggtcgccat ggcccgggag gtgggcctcg
      121 ccggccgcct ccagccgccc gccaccgcca ccgcctcgct ctggacgcgc gacgcgctgc
      181 gccccatgcc caagggccac gtcatgggcg tccccggcga cccggcggtc ctcggcgagg
      241 tgctgtcgcc cgagggcctg gcccggatcg ccgaggagcg cgacctcacc ccgacgcccg
      301 tcggcgagga cgtcgcggtc ggcgcgtacg tggccgaccg gctcggccgc gaggtcgtgg
      361 accgtctggt ggagcccctc ctcggcgggg tctacgcggg cgacgcctac cggatctcga
      421 tgcgcgccgc cgtaccccag ctcttcgaag cggtgaggga gggcggcccg ctgctggagg
      481 ccgtgggccg catccaggaa cgcgcggcgg cccggcagca gaccggcccg gtcttccagg
      541 gcatcgaggg cggcatcggc accctcccgg ccgctgtcgg cgactccgta cgggccgggg
      601 gcggcgacat cctcaccgag acgcccgtcc tcggtctgac ccgtacggaa acgggctggg
      661 ccgtccgcac cgacacccgg acgatcgccg ccgacggcat cgtcctggcc acccccgcct
      721 ggtcggccgg caccctgctg gccgccgagt ccccggccgc ctccgccgag ctgtccgggg
      781 tcgagtacgc ctcgatggcc ctggtcaccc tggccttccg gcgtaccgac atcgaggccc
      841 acgaggccct gcgcggccgc tccggcttcc tcgtaccgcc ggtcgacggg cacacgatca
      901 aggcgtccac cttctccagc aacaaatggc agtgggtcgc cgacgccgcc cccgacctct
      961 tcgtgctccg tacctccgtc ggccggtacg gcgaggagga ccacctccac cgcgaggacg
     1021 aggagctcgt cgccgtatcc ctgcgcgacc tcgccgcggc caccggactg accgcccggc
     1081 ccgtcgacag cgaggtcacc cgctggatcg gcggcctgcc gcagtatccg gtcggccacc
     1141 tcacccgggt cgcccggatc cgcgacgagg tcgccaagct gcccgccctg cgggtctgcg
     1201 gcgcggtcta cgacggcgtc ggcatccccg cctgcgtcgc gagcgcccac cgggcggccg
     1261 acgagatcat cagggagatc atcgccacgc cgaccctggt tcggggcacg gggagcgagg
     1321 cgggacaata gccgtatgag tgctcctgag actgcgacat caagcaagag tccgaacgcc
     1381 ggcaagaagg ccaaggacct caacgaggtc atccgctaca ccctgtggtc ggtcttcaaa
     1441 ctgcgcgacg ttctcccgct ggaccgcgcg ggatacgccg acgaggtcca ggagctgttc
     1501 gaccagctcg cggccaagga catcaccgtc cgcggcacct acgacctctc cggtctgcgg
     1561 gccgacgcgg acctcatgat ctggtggcac gccgagacct cggaccagct ccaggacgcg
     1621 tacaacctct tcaggcgcac caagctcggc cgcgcgctcg acccggtctg gtcgaacatg
     1681 gcgctgcacc gccccgccga gttcaacaag tcgcacatcc cggcgttcct cgccgacgag
     1741 acgccgcgcg actacatcag cgtctacccc ttcgtccggt cctacgactg gtacctgctg
     1801 cccgacgagg accgccgccg catgctcgcg gaccacggca agatggcccg gggctacccg
     1861 gacgtccgtg ccaacaccgt cgcctcgttc tcgctcggcg actacgagtg gatcctcgcc
     1921 ttcgaggcgg acgagctgta ccgcatcgtc gacctgatgc gtcacctgcg cgcctccgag
     1981 gcacggctcc acgtgcgcga ggaggtcccg ttctacacgg gccgcaggaa gagcgtcgca
     2041 gacctggtgg ccgggctcgc ataaccagcg agtcccgcac caccccagcc cggaagatca
     2101 gagggacggg caccgggcac cgatcgtgcc gtccgcccct ccagcgacac cgggttcggc
     2161 ttcgggggcc gtcgcaccgt gaaggtgcgg cggcccccgc tccgtgctca ccgcccggtc
     2221 agtccagcga caccgggttc ggctccgggt gcgcggcaca gtccgcaccc cgccccggca
     2281 cctcgccggt cagcagatac cggcgcagat ggtcgtccac gcaggtgttc ccggccccgc
     2341 cgatgccgtg cgtccccgcg ccccgctcgg tcaccagcga cgacccgggc agtcgcttcc
     2401 gcagctccaa cgcccccttg tacggcgtcg ccgcgtcccg ctccgccgcc aggatcagcg
     2461 ccggcggcag ctcgccccac cgcgtcccca cctccagcgg ccgctgccgg ggcgcgggcc
     2521 agaaggcgca cggcaggttc gtgaaggcgt tgtcccaggt ctcgaaggga gcgacccgcg
     2581 ccaggtccgt gtggtcgcgg tcccagacct cgaactcctc cggccagggc gcgtcgttgc
     2641 actcgaccgc cgtgtacacc gcctgtgcgt tctcgttgtc cttcgccgcc accgcacgcg
     2701 gagaggcctg cgcgaccagc ggctccgggt tgccccgcac gtactccgac agggccgtcg
     2761 cccgcatcgc ccagtagtcg tcgtagtaac cggcccccag gaaggccgaa tgcaactgcc
     2821 ccgggcccac cgtgccgccc gccggcttca ccgccagctc ggcgcgcacc tcgtcgtagt
     2881 gcttctgcac cgcctccggg gtggccccca ggtgatacac gtcgtcgtgc cgggcgaccc
     2941 agcgccggaa gtcctcccag cgcgtctcga aggccagcga ctggtccatg ttggagcggt
     3001 accagatctg ctccgggtcc ggatcgacca ccgagtcgaa gaccatccgc cgtacgtgcg
     3061 aggggaacag cgtcgcgtac agcgcgccga agtacgtccc gtacgacgcc cccatgaagg
     3121 tcagccggct ctcgccgagc gcggcccgca ggacgtccag gtcacgggcg ttgttcagcg
     3181 aggtgtagtg ccgcagcgtc gcgcccgcgt gctccgcgca gccctgcgcg tacgccttcg
     3241 cacgggcgac gcgccgctcc ttgtacgcct gcgtcgggtg cgtcggggca tccgtcgggc
     3301 ccttcgtgta cgcggcgggg tcctggcagg acagcgggtc ggaggagccg ttgacgccgc
     3361 gcggcgcgta gccgaccagg tcgtacgcct cggcgatctc cttccactcc ggcagctccc
     3421 cggccagcgg gaaggtgatg ctggacgcgc cggggcctcc cgggttgtag acgaacgcgc
     3481 cctgccgctc cttcggcgga ccggtggcgg gcgtgcggct gacggtcagt tcgagctgcc
     3541 gcccgtccgg ttcggcgtag tcgaggggca ccttcaccgt gccgcacttc agggagtccg
     3601 ggagcatctc ctcctcggga caggcggcga agtcgatccc ggcggcggtg gcccgggcgg
     3661 cggcgatcgc ggtgccccgg gcctcggcgg agcccggcgc ctcccaggcg ttcgcgggag
     3721 cggcggccag ggcggacagg accagggagc cgatcgatgt gtacagcgca gctgttctca
     3781 cgcgcggggc ctctctgcgg atgcggagag ggatggtcgg gcggacggcc gccgatgtcc
     3841 agtaccgccc cggaatgtca ccgggaacca ccctgatggt cggtcaacaa ccgtacggtg
     3901 agccccggtt cgccgggatc aggagctgtt cgggtcagga gcggttcagg acccgccgcc
     3961 gcagctggag cccccgcccc cgcccccgca gctggagccg cccgagctgc cacagctcga
     4021 cccgctgctg cctccgcacc cggacccgga ggaacatccg gaccccgagg agcacccgga
     4081 cccgccgccg cagctcgatc cggagcctcc cccggtcgac ccgccgcagc tggagccgcc
     4141 ggggctggac gcggcgcacc agaccgtcgc gacgccgacg gcggtgacgc ccgccgccgt
     4201 ggacccggtg acgtacgacg aggaccgccg gcgcggagcg ctcagccgtg ccgcggccac
     4261 cagctgggcc tggaacaccg ggtccggcag cgcgcggagc cccagcgtgg cgacgaggtg
     4321 ggcgggggtc accacatggg cgtaggcggc ccggaacgcc agggcggcgt gctgccccga
     4381 cttcgtgatg cggctcgcgg aggtgcccgc gacgatcagg ccggtgaacg cgccgatcac
     4441 gatcgcgggc aggaccttca cgatgaacgg gaccgggaag tccatggtgt cgaccacggc
     4501 gagctggacg aacgtgacca ccaggctcaa cggcagggcg atgaggcatg ccaccccctg
     4561 gatcagcccc catcgccgca gcggccggac ccggtggggc ggcaccagca gcccgcgcgc
     4621 ggcgagcccg tcgccgacct cctggacggc cgggtggcgc atcacccttt cccgcaggac
     4681 gtgcagcgcg ccgctcgggg cggcggccag ctcctggaac accgcacgtt ccaccgggtc
     4741 gttcgcctgc gcccaccgta cggcgacgat gccgggcccg ccgacggcca gccggccgtc
     4801 cgcgtgcagg gcggtcagag cggtgtccac caccctggcc ggaccgccgt tcaggaacgc
     4861 gacctcgtac aggtcgtgaa gggcgacgcc gggacccgga gcggggcggc gggaccgctc
     4921 ggccaccgcc ttgacgacga gcagcaccga cgagacgacg atcccgaggg tcgccagcag
     4981 agcgaagacg ttcacagcgg tcacttcccc acgaggacgg cacgggccgc ccggaccaga
     5041 cgggtggcgc ggcccggcgg ccgggcgccc gaccggtcct gccaccagta cgtcagccgg
     5101 cgccgggccg ccggatcggc gggaccgccc gcgatgagca catgctccgc gaagtccagg
     5161 gcgtcgcggc ggtacccacc ggacatgggc cggctgccgg cgtacgcgag gaacccggca
     5221 cggtagccgt cgccgaggat ctccggcagt tcgggggcca ccttggcgac gacgtcggcg
     5281 cgcttggcgg ccagcgcccg gctctgcacc cgcagccgcc ggtggtcgaa gccctcggga
     5341 gcgggagttc cggccaccag cgcggagagc agcgcggtct gcgcgacggc ggtacggtca
     5401 cgggtgccgg cgggcacggg gtcggctacg gcgcggcctt cggcgggcgc ggggtcggcg
     5461 acgcccgtac gttcaccggc tccggcggtg ctcgtacgtt caccggctcc ggccgatacc
     5521 gggtcggcga cgcccgtacg ctcaccggcc gcggccggca cgcgtacggt cgccgcccgc
     5581 cgcagcgtcg cccggatcgc gtccagttcg cccgccagct ccgcgcccgg cgggaacgcg
     5641 tcgtcccgct ccagcagcac gcccggcggg tcgacccggg aacgcagctc ggccagcacc
     5701 tccaggacgg gttcggacac cggatgggcg tgcgtgtcgt gccagacgcc gttcttctcc
     5761 accccgcccg ccacatgcac gtacgcgatg gcctccaccg gcagctcgtc cagcgccttc
     5821 gccggatcct ggccgaggtt gacgtggttg gtgtgcagat tggccacgtc gatcagcagc
     5881 cgcaccccgg tccgctcgac cagctccgcc aggaactgcc cctcggtcag ttcctcgccc
     5941 ggccaggaga tcagcgccgc gatgttctcc agggcgagcg gcaccggcag cgagtcctgc
     6001 gcgatccgca cgttctcgca cagcacgtcc agcgcgtccc aggtgcgcgg caccggaagc
     6061 agatgccccg cctccagcct cggcgacgcg gtcagcggcc ctccggcccg tacgaacgcg
     6121 atgtgctcgg tcaccagcgg cgtccccagc agttcggcgc gcgccgcgag agaggcgagg
     6181 cggccggggt cgggccggtc cgcgccgccg agcccgagcg ccaccccgtg cggcacgacg
     6241 gtcaccccgc gctcccggag ccgtaccagg gagtccggga gatggtcggc gcagaggttc
     6301 tccgcgacgg cctcgaccca gtcgatcccc gccagcgcct ccacctcgtc cgcgatctcc
     6361 ggccgccagc cgatgccgat gcccagctcc atgctgtccc cctgctcacc caggcttcgc
     6421 cccgtcgctc tgtccagggg tcatgacccc gtcgaacggt gccgaacccg acagagggga
     6481 cgttcagagc tggatttgag gttccgggac cggcggcctc gttatggcat cggcatcatc
     6541 gtgggcggca ccgggcgcga ggtgaaggac tggtccccgg tcggcgtcgc cggcaccggg
     6601 gccagcggga cctggccgtc ccggggcatc gacgggcccg agggactggc ggtcgacccg
     6661 ctcgccgctt cacgcgccag ggcgtcgaag tcgacgaagc cggtggcctc cagcatggtg
     6721 atgtggtcca gcacggtctg gttggcgtcg ctcgccagct gccggatcag cgtgttccgg
     6781 gtggtgtggc ggacctggcc gatgaggccg aaaaccttgc cgtgggcggc gcgcaggatg
     6841 ttggcgaact tccgctcgta ctcgtccccg ctggccgccg tcagctctcg cagccactcc
     6901 tgctgctggg cggtcggctg gttgggcagc tccaccccga gtttcgccgc cacgtcccgg
     6961 gcccgccggt ccaggtccgc gtgcccgacg acgaggtggt ccccggcggc cttcgtcgcc
     7021 tcgctgggcg cccgttcgat cgcctgctgc ccggcgggca gctcccacag tccggcgagc
     7081 cgcaccttga ccaggaagtc ccggtcggtc gcggacagcg gcccccactg ggtcgcgaca
     7141 ctggaggcgt tgaggttcgc ctcgccggtg cccgaacggt ccgcgtagga ccagacgggg
     7201 aacgcgagtg cgccgatggt ggcgaccagc gccgcgatga tgagggccgt tccgttgatg
     7261 cgtcgcaaca aggtgtctcc cgggccgagg cgtgacagcg tcgaacaggc gtcgaatcaa
     7321 ccgccaaccg actggctgtg caggctactt ggcggtaatg ccgaaagggc agtaccggga
     7381 gatacggaga agggaccgga aacgttcagc gcggcgacga tgtggtcgcg tcccgctcgg
     7441 cggctccgcg acacgggcga tccgtcgtgg tcaccgcccc gctcagcggc gcagcgccgg
     7501 atggtcggcg accaccgtgc aggagcccgg ggcgatctcg gtgaaccccg cgtcgcgcac
     7561 caccggcagc ccgctcaccg tcagctcccg ccagcgctcc gcacccgggg tggcgacgga
     7621 gagcgggaac ccggcctcgc gccaggcctt gcgctcggcg tcggacagct cccaccaggc
     7681 gagctgcgcc ccgtgcccgg cctgggccat cgtcttgccc gccgacatgt ccacctcggg
     7741 gttcagccac agcacggggc ccgagagatc gggcgccgcg ggcggctcgg ggtcctccag
     7801 gtcggtgccc gagacctgga gtttggccag ctccttgggc cagccgtcca gcgggatcgg
     7861 cgggaacacc cgtacctccg cgccgtcctc gcccgtcacc gtgatgccgt ccagcgccgc
     7921 ggccttgcgc cactccgcac cgcgcgcccg gcgcacgacc ttgcggatcc gggcgtcctg
     7981 ccagtcccgc atcgccgcgg cccactcgcc gtcgccgagg gaccgctcgt cggagaggat
     8041 cgtcagcacc gcgcgggcgg cggtccgcag cgcgtcggtg cgggcgggcg ggtccgtctt
     8101 ctccaggtgg agcaccagcg gcagcacgaa ctgcggcgcc tggtcgcggt cggtcggacc
     8161 gttgtggaac gggctttcgg agacaggggt gtcgttgctg gtcaccgccc cagtctgcca
     8221 ggtggtcggt tcaccttctt ggcggaacga ccggctccgg gtgaggatgc tccgcatgaa
     8281 gagcgatctc ttttccagcg agcacatggc ccagccggcc accgcccccg gtatgaccct
     8341 gcagaactcc aagtcgatca agtacgccgt caacggggag atgcacgccc ggcagggctc
     8401 gatgatcgcc ttccgcggca acctccagtt cgagcgcaag ggccagggca tcggcggcct
     8461 gctcaagcgc gcggtcaccg gtgagggcct cgcgctgatg gcggtccggg gccagggcga
     8521 ggcatggttc gcgcacgagg cggcgaactg tttcatcgtg gagctggacc agggcgactc
     8581 catcaccatc aacggccgca acgtcctgtg tttcgacccg acgctctcct acgagatcaa
     8641 gacggtgaag ggcgccggaa tggtcggcgg cggcctcttc aacagcgtct tcacgggtca
     8701 cggcaagctc ggcctgatgt gcgagggcac gccgatcgtg attcccgtga cggccgctca
     8761 gccggtgtac gtggacacgg acgcggtcgt cggctggagc cagcagctcg cgaccagcct
     8821 caaccgctcc cagagcgtcg gctcgatggt gcgcggcggc tccggcgagg cggttcagct
     8881 gatgctccag ggcgagggct tcgtcatcgt gcggcccagc gaggcccggc ccgagaagac
     8941 ctccaactga ccctgcacct cgagggagtg ggccaccggt acggcctccg cggcgcctgg
     9001 gtgctgcgcg gggtcgacct cgtgctgccc gcgcgggcgc tcgtccgggt cgagggtgcc
     9061 aacggagtcg gcaagccgac cctgctgcgg ctgctcgccg ggatcgacgc cccgccgagg
     9121 gacggatcac cggccgcccg gcccgtacgg catacgtccc cgagcgcttc ccggctgcgc
     9181 tgccgctgac cgccaccggc cacctcggcc gggtcccccg aggcagcagc agaggtgtcc
     9241 gaagcaccat gaccgccctc ctccgctacc agaccggcct gctcgctccc tcccagcgct
     9301 ggctggcgcc tctcctgctg tacgcggccg tcctcgccgt cggcctgcgg ggcgggcagc
     9361 ccgtgctggg ctcgctcggc gtcgcggccg ccgccctgct gcccgtgacc gcgtgggccg
     9421 tccacctctg cgtcacccag gagccgcccg ccgcccggac ggtcgcctcg gccgccgtgg
     9481 gccccgggcg ggtgcacctg tccgcgctgc tcgccgccac gggctgtgcg gcggcgctcg
     9541 ccgtggtgag caccgccgtc gtcctgctcg tcagcagccc ggccaccgac gacggcgccc
     9601 acgcggtctc cggaccgtcc gccgcgctcg ccggacggac ggcggccctg tgctgcgtcc
     9661 tgctgggcgc ggtcgtgggg gcgctcagca gccgcccggt gacggtccgc aggggctggt
     9721 ccgtggcggc ggccgtgctc ggctcgctcc tcgcgctggt gaccaccgga tccccggcgc
     9781 ggcacgcggt caccgccctg gtcacgggat cacggaccgg gatgttccag ccgcccggcc
     9841 tgcccctgct cggggcggcg gtcctcgccg ggtcggtgac ggctgccgtc tgccggctcg
     9901 ccgcccggcg cggctgagcc gggcggatga gtaggctcgt ggacgtggac acggacgata
     9961 cggacaacac gtactgcgag gctccgggac cgatcgcgcc cgccccgccc gccggagccg
    10021 ccgaggggcc tccgtacgcc gagtgcgtgc tgtgccgcga gccgaccgag tacccggagt
    10081 cgacgaaggg cgccacgctc tgcccggtct gcgcctggca ggaggcgggc cgcacggcct
    10141 gttccggctg agagctgacc cgtacatgct ctccgagctg ctccgggcat gccggtcggg
    10201 gtgaagccca tggccgggga gcgccggttc agccgaggac gtgccgcaga taggactgcg
    10261 ggtcggcgag gtagcggcgc cagtgatcga ccagagccaa gtcgctccag gccacgcggc
    10321 gcatgccgtg ctcgccgatc tccacgatgt ccgcgccggg aaaagcggtc aggagggggg
    10381 agtgggtggc gcagatgacc tggccaccgt tcttcaccag ttggtcgatg tgaccgagca
    10441 gttccaggca ggaagagaac gacagcgcgg cctccggctc gtccatcaca tacagccccg
    10501 gccggaagaa cgtgccccgg aacgcggcga ggaagccctc gccgtgactg accgagtccg
    10561 gtgcgaatcc ttcccggtcc agggcgtcca gcgccgtctc ggcgcgcagg aagaacccct
    10621 tacgggctga ccagctgccc atcatgcgcc gcccgtacgc agtcgcgtcg agccggatcc
    10681 gctcacccag caccgatttg ggccgatggc tggcgtagcg ccagtcgtgg gagccgcccc
    10741 aggagtccag gccgaagccc tcggcgatgg cctccaccag tgtggacttt cccgagccgt
    10801 tctcgccgac gagaaaggtc accggcgcgg tgatccgcag tccctcctcc agcagctgac
    10861 gcacacacgg cacggaccag ggccactccg accggtcgta cgaggccaca tgtgcgtacg
    10921 cacgttcgat gatcatgggg tgagtctccc agagggcgcg gaaaggagtc cacggtcgcc
    10981 ggtgcggacg ggcccggagc ggcggccgga gcgggcgagc ggtgcgggca gcagggcgag
    11041 gggtgcggcc atgacgatgg ggacggtgat cgccacggcg agggcggcga tcccttggaa
    11101 gtccctgaac cacgcggcga ggtgctgagc ccggggttgc gcggtctgcg tgccgcgggg
    11161 tcgttgtcgg gactggtcct actggagttc gctgaatcgt tcggtcgctc gggtccgtcc
    11221 ggccacgatg atggtgtcgt ccgcctcgac tacggtctcg gcggtggcgt aggtgaagcc
    11281 ctcgccgggg cgcttgatcg cgacgaccgt gatgccgtag cgggtgcgga cggcgctgtt
    11341 ggacaggggg aggccgatga tgtcggtggg cgggttggtc ttgaccatgg cg
//
