LOCUS       NZ_JALDPQ010000067     12910 bp    DNA     linear   CON 28-MAY-2024
DEFINITION  Streptomyces sp. TRM75563 738, whole genome shotgun sequence.
ACCESSION   NZ_JALDPQ010000067
VERSION     NZ_JALDPQ010000067.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TRM75563
  ORGANISM  Streptomyces sp. TRM75563
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 804357)
  AUTHORS   Chen,Y.
  TITLE     Streptomyces aheensis sp. nov., isolated from road
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 804357)
  AUTHORS   Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2022) College of Life Science, Tarim University,
            Hongqiao, Alar 843300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 14-MAR-2022
            Assembly Method                   :: ABySS v. V2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022748615.1-RS_2024_05_28
            Annotation Date                   :: 05/28/2024 05:18:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,476
            CDSs (total)                      :: 7,413
            Genes (coding)                    :: 7,165
            CDSs (with protein)               :: 7,165
            Genes (RNA)                       :: 63
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 249
            CDSs (without protein)            :: 248
            Pseudo Genes (ambiguous residues) :: 1 of 249
            Pseudo Genes (frameshifted)       :: 108 of 249
            Pseudo Genes (incomplete)         :: 202 of 249
            Pseudo Genes (internal stop)      :: 19 of 249
            Pseudo Genes (multiple problems)  :: 75 of 249
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:22:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 193815
            Orig. end                         :: 206725
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALDPQ010000067.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12910
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hydrogen-cyanide"
                     /region_number="2"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /tool="antismash"
     cand_cluster    1..12910
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12910
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7910](+)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7910
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
     misc_feature    complement(1156..1169)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.87"
                     /tool="antismash"
     misc_feature    2283..2295
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
     gene            complement(2359..3537)
                     /locus_tag="MQC87_RS33410"
                     /old_locus_tag="MQC87_33410"
     CDS             complement(2359..3537)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0045227 - capsule polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072430.1"
                     /locus_tag="MQC87_RS33410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_33410"
                     /product="CapA family protein"
                     /protein_id="WP_242742771.1"
                     /transl_table=11
                     /translation="MSRSLALLAMAVGLTVSCGTEPAQPQAKAGGRSFTVAAAGDVLIH
                     PELVEQAAKDAKESGHGEAGLDFGPLLAGVKPVISKADLAICHMETPVGKPEGPFQGYP
                     EFLVPPQILTSLKDVGYDTCSTASNHTFDHGLKAVRRTLDTMDKVGLGHSGSARTPKEA
                     EQINILDVNGVKVAHLSYSWESFLNPTPKKQSWAFNRSSTNEIKKAEKRARSQGAEVVL
                     LSVHWGLEHYNEPSVPQLDMAQRLTEETGVDLVIGHHAHVVQPIQKVNGTWVAYGLGNQ
                     VARHSSPTGLTEEGAIGWFEFRETADGWDVSARYRTTQMDIPPEVEPGEKAPEGAVENL
                     RLVDVQQALGNPEGLSEDRIARYRLAEDRTRGFLYNRGAPGGDGLKRLSLDK"
     gene            3651..4544
                     /locus_tag="MQC87_RS33415"
                     /old_locus_tag="MQC87_33415"
     CDS             3651..4544
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059567.1"
                     /locus_tag="MQC87_RS33415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_33415"
                     /product="hypothetical protein"
                     /protein_id="WP_103512521.1"
                     /transl_table=11
                     /translation="MLLALVGCQTDASPTSEDSVPRARELVDLRSRVLGYTAKLRADAP
                     YGPPGKSQRVRLAKAVGSLLSGDAREAERQLAPLGLGLTRLTDTDSGRRYDEIAATGPG
                     RSARWGRLYLNADSTVRWNAQVPHPVSDRDTEVLGVRLLEENPGGALVLAGAHRRAGEN
                     GAADVAHREDSAFHAIVVELQKRGVPGVQLHGFADSADRPYDAVVSTGAVEAAPAEVVA
                     MADRMDDKGLRVCRAWAARCPLEGRANVQGRSADREHARFVHVELARHARADDGRDTEE
                     AIDALGGLVAGWTAGG"
     misc_feature    complement(4931..4951)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.93"
                     /tool="antismash"
     misc_feature    complement(4953..4963)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.4"
                     /tool="antismash"
     gene            5001..6161
                     /locus_tag="MQC87_RS33420"
                     /old_locus_tag="MQC87_33420"
     CDS             5001..6161
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454561.1"
                     /locus_tag="MQC87_RS33420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_33420"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_242742772.1"
                     /sec_met_domain="DAO (E-value: 1.1e-66, bitscore: 221.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /sec_met_domain="Trp_halogenase (E-value: 7.5e-06,
                     bitscore: 20.4, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVVVVGAGIVGAACAFHAVAAGLDVTVLDRGPVGAGTTSRGEGN
                     ILLSDKEPGPELELARLSRDLWDEAAEELGPESVEFETKGGLVVASTPEALTVLHAFAA
                     RQAESGVRTEPVERPGDLEPHIAPGLPGGVHYPQDAQVQPVLAAAGLLRAAVRRGARTH
                     TGEAAAAVTAADGRITGVRTADGTVLPADAVVNAAGTWGGEVGRRLGAPVEILPRRGFV
                     LVTEPLPPMIRRKVYSADYVANVASSDAGLETSCVVEGTRAGTILIGASRERVGFDTAM
                     NPAVVTALAAQACRLFPFLRGVHLIRAYRGFRPYCPDHLPVVGPDPRVPGVVHACGHEG
                     AGIGLAPATGALVTAHLLGKPWRGADPAAHTGLLPHRFLTTGGVPK"
     gene            6158..6421
                     /locus_tag="MQC87_RS33425"
                     /old_locus_tag="MQC87_33425"
     CDS             6158..6421
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454563.1"
                     /locus_tag="MQC87_RS33425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_33425"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_103512523.1"
                     /sec_met_domain="Fer2_4 (E-value: 8.7e-26, bitscore: 85.3,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTAFTVDGEPLPFVPGQTLAAALVASGRVAWRTTRGGQRPRG
                     IFCGIGVCFDCLVTVDGTGGQRACLVQARPGMAVTTGEDGDE"
     gene            6414..7910
                     /locus_tag="MQC87_RS33430"
                     /old_locus_tag="MQC87_33430"
     CDS             6414..7910
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608089.1"
                     /locus_tag="MQC87_RS33430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_33430"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_242742773.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 6.1e-20, bitscore:
                     67.0, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 6.2e-12, bitscore:
                     41.2, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSESGDLVVVGAGPAGLAAAATALDGGLRVVLVDSGAALGGQFWR
                     HPPLPAQEAVPTADLHHGLGAYRELCATLAAHERTGRLTLLLNHHVWTTARVDDGFAVH
                     AVDRSRAPEERTVVLRAPALLLATGAYDRQLPFPGWDLPGVLTVGGLQALLKGGGVVAG
                     RRVVLGGTGPFLLPVAAALAARGAEVVAVCEAAAPSAWLRHPAALLRNPAKWAEAARYA
                     GTLARHRIPVRTRTAIIGAEGGAEGQAEGQAGVGAGAEGRVAFVRTASLDADGNPLPGT
                     ERRIAADTVGVGWGFVPQLDLLLPLGCALADAGDGTMAAAVDDGQRTTVPGLYTAGETC
                     GVGGAALAVSEGRVAAVSVLTDLSAPGLPNARRLAAERRAVIRHRAFARAMAQAHPLPP
                     AWPAWLTDDTPVCRCEEVTAGAVRSARADDAAADHRQVKQLTRAGMGWCQGRMCGPAVH
                     CLVARDQPYAPAERLIATPVSLGALADAGESTPDPASDPT"
     gene            7920..8828
                     /locus_tag="MQC87_RS33435"
                     /old_locus_tag="MQC87_33435"
     CDS             7920..8828
                     /EC_number="4.1.3.3"
                     /EC_number="4.2.1.41"
                     /EC_number="4.3.3.7"
                     /GO_process="GO:0009436 - glyoxylate catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0071704 - organic substance metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454567.1"
                     /locus_tag="MQC87_RS33435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_33435"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_103512525.1"
                     /transl_table=11
                     /translation="MDRTSPRTRMPWHGVIVATSLPFGQDLAVDHGAYGDNVAWLAEQG
                     LHGVAPNGSLGEYQTLTYEERDRVVETAVAHAPEGFTVMPGVGAYGAIEARRHALFAKD
                     AGCQAVMCLPPNAYRADDRAVLEHYAMVASAGLPVTAYNNPIDTKVDLRPELLAKLHAE
                     GFIVGVKEFSGDVRRCYAINELAPDLDLIIGTDDTLLEVAVAGAKGWVAGYPQVFPRAC
                     LDLYNASLAGDLDTALPLYRRLHSVLRWDSRTEFVQAIKLGQDMIGRTGGVCRPPRQAL
                     DPETEAVVRSATQALIDAGVN"
     gene            8830..9831
                     /locus_tag="MQC87_RS33440"
                     /old_locus_tag="MQC87_33440"
     CDS             8830..9831
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378674.1"
                     /locus_tag="MQC87_RS33440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_33440"
                     /product="proline racemase family protein"
                     /protein_id="WP_242742774.1"
                     /transl_table=11
                     /translation="MRSKVCYHAVDSHTEGMPTRVITGGVGVLPGATMAERRQRFMAER
                     DGLRTLLMCEPRGHASMSGAILQPPTRPDADFGVLFIEVSGCLPMCGHGTIGVATVLVE
                     TGMVEAVEPETLIRLDTPAGLVTARVAVRDGRAESVTLENVASYSHALDQVVEVAGFGP
                     VRYDMAYGGNFYAVVRTEDLGIPFDRSEKGRLLDAGLAVMKAINEQNPVVHPENPAIDV
                     CHHVYLEAPGSTAEHSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGLLKAGQDFVNES
                     FIGSRFTGRILGESTVGGRPAVLPSVTGRAWITGTAQYLLDPTDPYPTGFTV"
     misc_feature    8836..8851
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.49"
                     /tool="antismash"
     gene            9828..10952
                     /locus_tag="MQC87_RS33445"
                     /old_locus_tag="MQC87_33445"
     CDS             9828..10952
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378673.1"
                     /locus_tag="MQC87_RS33445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_33445"
                     /product="proline racemase family protein"
                     /protein_id="WP_242742775.1"
                     /transl_table=11
                     /translation="MTADPAAAHSTGPSAGPSAGPTGTARPYTTPIRTADWHTGGEPFR
                     IVPEAPPVLTGPGLTVSERRTVAIADAGAQWTRALLCGEPRGHADMYGAFLVPPDDAGA
                     HLGALFWHKDGFSTACGHGTIALGSWAVATGLVAAPPDGTTDVVIDVPSGRVTAAVRTA
                     GGRVADVTFVNVPGHVHARGVEAATSYGSLAVDIAFGGAMYAVLPVDRLGLGLRVRPGD
                     VTALIAAGREIRDALNAVRAAEHPDDDRLSGVYGTVFTEEAAAPVELPDGTGRLHHRNV
                     TVFADGQVDRSPCGSGTAARVALLADAGELRPGDELRHESVVGSVFRARIERTVTVHGR
                     PAVVPAVTGTAYATGTGRFTVDPDDTLVPGFVLR"
     gene            10949..11911
                     /locus_tag="MQC87_RS33450"
                     /old_locus_tag="MQC87_33450"
     CDS             10949..11911
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072438.1"
                     /locus_tag="MQC87_RS33450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_33450"
                     /product="ornithine cyclodeaminase family protein"
                     /protein_id="WP_242742776.1"
                     /transl_table=11
                     /translation="MTVTLDAADVSALGPVAAVAAVREALAAGLDPDGDVPRAVVPLAH
                     GQGLLMPSEHGGWYGVKVATVAPGNAARGLRRINATYLLHDSATLTPVALLDGVALTTL
                     RTPAVSVAAGLERLRALAAGCEDGDEDRGLRLVVFGAGPQGEGHVATVRAHVPVADVAV
                     VTRRGGPVPGWADRRLAADDGGVAALVRRAEAVVTATSARRPVVDGRLVRDDAVVLAVG
                     SHEPDVRELDSVLMGRATVVVESREIALREAGDVVLAIREDMLAPDDLLTLADLPGARA
                     AAVPADRPLVVKTCGAGWQDLVIAVAAYRRKVGVVVKRG"
     gene            complement(12092..12802)
                     /locus_tag="MQC87_RS33455"
                     /old_locus_tag="MQC87_33455"
     CDS             complement(12092..12802)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128212.1"
                     /locus_tag="MQC87_RS33455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_33455"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_103512529.1"
                     /transl_table=11
                     /translation="MSELKSRKLISVQEHLRDQVANALRAALIAGELQPGVIYSAPTLA
                     AEYGVSATPVREAMLDLAREGLVEAVRNKGFRVTELSERDLDEYTEIRALIEIPTIGRV
                     TRTASREQLEALRPVAEEIVTAAQGGDLIAYLESDRRFHLELLALAGNTRLVETVADLR
                     KRSRLYGLTDLSEEGSLVSSAREHTALLDIMIAGDAEAAEAHMRGHLAHVRTLWAARKR
                     EAERAAPTRKLGAR"
     misc_feature    12830..12846
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.35"
                     /tool="antismash"
     misc_feature    12834..12844
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 20.42"
                     /tool="antismash"
ORIGIN
        1 ccgacctcgt cctggtagcg ggggtagtgc acggtcttga ggtctccgtc ggcgagcttc
       61 tcggcaccgg ccgcgagggc ccgcaggggc cgtacgacga cgaggtggat ccagcccagg
      121 cagaccacga tcagggcgag gcccagcaga ctggcgagca cgctgcggtc ctcgcgctcg
      181 taggcggtga tctcgaaccg ggcggcgttc tgccagctga cgacggtcca gccgacgtcg
      241 gaggcgacac cgccgccggt gaacggcgcg gcggcggcca cggtgaccgc gccaccgtcc
      301 cggatgagca gaccgttctc caacggcccg gcgcccacct gcacgttggc ggcgcgcacc
      361 aggtcgggca gcacgtcgtt cggcagcccc tcgaaggcgc ggaagccgtc gctggcggcg
      421 accgtccgcg cttcggtgtt cacgatccgg acctcgccga gaccgggccg cttcagcagc
      481 gagttgagga actccacccg cacctcgccg accagggtca tgccctcgtg ctccggcacg
      541 ggcgccccgg cctgcacgac gggcttcttc tcgccctggc cggagacacg gaccagcgag
      601 gagtccttct ccgtggtcca cgggtgaggg tcgccgccgg cccgggcgac gacgacgccg
      661 tccttgccga cgacgtacag cgcctgatag cgggagtgct cccgcagggc gcccttcagc
      721 aggttctcgg tggcggcgac gtcgtcggtg tcgagcagac gcgaggtgga cacgaggtcg
      781 gcctgggcct cgttgagcgc ccggcgggcg cggtcggcga ccagatcggt gcggtcgcgc
      841 tggtcgttga ccatgaccgc ggggatgctc acggtcccgt ccgtgcggtt gagcagaagc
      901 ccgacgggga cgcaccacag cagcaggagc accgccgtca gcaccagcgg tccgcgcgca
      961 ccgccccgga acctgccggg cggacgggca ccggcggccc cgtcctgggc gctcgcgccg
     1021 ccgagctgcc cgcggatgcg ctccagcgcg gcgccgatcc gggcggcctc gccccagcgg
     1081 ggcaccgtga ccggccggat cagatcgccc cgggcgaggc gtcgggactc caggaacagg
     1141 ccgagcagcg gacgctgcac ggtcatccac agcacggcga ccgagagcag tccgagcagg
     1201 accagcgcgc ccgccgcgag cagaccgaag agctgccggt tgtcctcggc gagggtctgc
     1261 tgctggacca cgggaagcat ggcgacgacc gtgaggccga ggccggcggc gacgctctcc
     1321 ccgtcctccg ggtcggaggc ggcgagggag gcgtacccca tggtggcgac ccggccgttg
     1381 tacgccccgc ccagcagggt gccgctcacc ccggggtagc cgcgggagcc gggctcccgg
     1441 gcgctgaccg ggttctgctc ggtctcctcg gccgcctggt cggacagccg ggtcatctgc
     1501 ttctgcagga aggtgagttc cttgcgctcc gcgtccgagt tgagcgcctc ggactgctcg
     1561 aagccggcgg tggcgaggat ttcgccgccc cgcgcgacga cggccatgct gcggaacggg
     1621 cccaggttga tgggcggcac ggagaggctg ttggaggcga ccagcagctg ctgcgccccc
     1681 tccttcccct ccaggacggc catcgtcatc agccgtacgt caccggtctc cagccgcacc
     1741 atgcgcgggg tgagggcctt gtcgccggtg aggacgtcct tgtccaccca ggccagcggg
     1801 atgcgctcgc cgcgggcggc gagcaccttg ccggtgccca ggtccagcac cgtggtgccg
     1861 gtccatttct ggtacgcctt gctcaggtcc gacagaacgc gctcggggtc cgtcgtgctg
     1921 cccgcgttca gcgcggtggc ggtgcgttcg aggtcggtga cccgctcgtc gatcgaggcg
     1981 cgcagggcga tggcgccgtc ctgggcgaag tactgctgcg aggagagcac cgccttgggc
     2041 acgaccggtt ccgcgccggg tcccagcacc ttggccgtga gacccgcgag ggcgaggatc
     2101 aggacgcaga gcaacgcgat cggcggccgg atgccgccca gcagcggcat gtccgcacgt
     2161 ctgcggatgc gccgccggcc tttcggcacg aggggcgcgg caggagtcga tgtcaccggt
     2221 tttcttcctt ggtcgctgcg ggtgctcagt gcccggagga agcaccgctg tcgcatggct
     2281 gcgagacgct gtcacataaa agacggataa gcgcctaata ggttgtatct gccagcgtgc
     2341 agaaaaatgt gggcctgatc acttgtccag cgacagccgc ttcaggccgt caccgcccgg
     2401 cgcgccccgg ttgtagagga agccgcgcgt acggtcctcg gccagccggt agcgggcgat
     2461 ccggtcctcg gacagccctt cggggttgcc cagggcctgc tggacatcga cgaggcggag
     2521 gttctcgacc gcaccctcgg gagccttctc cccgggctcg acctcgggcg ggatgtccat
     2581 ctgcgtcgtg cggtagcggg cggagacgtc ccagccgtcg gcggtctcgc ggaactcgaa
     2641 ccagccgatg gccccctcct cggtaaggcc ggtcggcgag gagtgccggg ccacctggtt
     2701 gccgaggccg tacgcgaccc aggtgccgtt gaccttctgg atcggctgca ccacatgggc
     2761 gtgatgaccg atcaccaggt cgacgccggt ctcctcggtg agccgctggg ccatgtccaa
     2821 ctgcgggacg ctcggctcgt tgtagtgctc cagaccccag tgcacggaga gcagcaccac
     2881 ctcggcgccc tgggagcggg cccgcttctc ggccttcttg atctcgttcg tgctggaacg
     2941 attgaaggcc cagctctgct tcttgggtgt ggggttgagg aaggactccc aggagtacga
     3001 gaggtgagcg accttgacgc cgttgacgtc caggatgttg atctgctccg cttccttcgg
     3061 cgtccgcgcc gacccgctgt gccctaggcc caccttgtcc atggtgtcca gcgtgcgccg
     3121 cacggccttc agtccatggt cgaaggtgtg gttggaggcc gttgagcagg tgtcgtaccc
     3181 cacgtccttc aggctggtca ggatctgcgg cggaaccagg aactccgggt atccctggaa
     3241 cggcccctcg ggcttcccga cgggcgtctc catgtgacag atcgcgaggt cggccttgct
     3301 gatcacgggc ttcaccccgg cgagcagcgg tccgaagtcc agtccggcct ctccgtgccc
     3361 gctctccttc gcgtccttcg cggcctgttc gaccagctcg ggatggatga ggacatcacc
     3421 ggccgcggct acggtgaagc tgcgcccacc ggccttggcc tggggctgcg ccggctcggt
     3481 gccgcacgac acggtcaggc cgacggccat cgccaggagg gccagtgaac gactcatgcc
     3541 gagagaatta cggattgtca ctaagtcata cttacatggc cctcatggcc gaccttcgga
     3601 ttgtcatcac gggatggtca catttgctgc gcactttcat cgcactaggt ttgctcctgg
     3661 ctttggtcgg ctgccagacc gatgcgtccc cgacctcgga agattccgtt ccgcgcgccc
     3721 gggaactggt cgacctgcgc agccgcgtgc tcgggtacac ggcgaagctc cgtgccgatg
     3781 ctccctacgg tccgccgggc aagtcgcagc gcgtacggct ggcgaaggcc gtcgggagcc
     3841 tgctgtcggg tgacgcccgg gaggcggagc ggcagctcgc cccgctcggc ctcggcctca
     3901 ctcgcctcac cgacaccgac tcgggtcgcc gttacgacga gatcgccgcc accggaccgg
     3961 gccggagtgc ccgttggggc cggctgtatc tgaacgccga ctccaccgtc cgctggaacg
     4021 cccaggtccc gcaccccgtc tccgaccgcg acaccgaggt cctcggtgtc cggcttctcg
     4081 aggagaaccc cggcggcgct ctcgttctgg cgggcgccca ccgccgggcc ggcgagaacg
     4141 gcgcggccga tgtcgcccac cgcgaggaca gtgctttcca cgcgatcgtc gtggagctgc
     4201 agaagcgcgg ggtgcccggc gtccagctgc acggattcgc cgactccgcc gaccgtccct
     4261 acgacgccgt cgtctccacc ggcgccgtcg aggcggcgcc cgccgaggtg gtggcgatgg
     4321 ccgaccgcat ggacgacaag ggcttgcggg tctgccgggc ctgggcggcg cgctgcccgc
     4381 tggagggccg ggccaacgtc cagggccgct cggcggaccg cgaacacgcc cgcttcgtcc
     4441 acgtcgagct ggcccggcac gcccgggcgg acgacggacg cgacaccgaa gaggccatcg
     4501 acgccctggg cgggctggtc gcggggtgga cggccggcgg gtagcccggc acggcatttc
     4561 ggagcagttc ccttccaggt gcttgctccg gaggcggcgg gcccggcgcc ggcgggcgcc
     4621 tcttccgggg cccgtccgac gtcgggcgtt gccgcttgcg ccccggccgc cccggttggg
     4681 cccggtgggc ccggtgggcc gcaggaaggt ccgtactcct tcggcggcga gcggccgtac
     4741 gcgggtgccc tgcgcggcgc tcgggggccg agccgggcat gtgtcgcggg gcccgtcctc
     4801 gcgttcgtga cgctccatca gggccaggtc ggcgaggggg tgccgtacgc gcctcgaact
     4861 cttccgtgcg ggcggcgggt gcccggggga aagtcaccgg ggcggcggcg ttgtcctcgg
     4921 gtcgtccgga tgtatagcct aagcaatggc atgtgacatt gcactagcgg gcggccgtga
     4981 tggcgcgcta aggggtggcc atgaaagtcg tagtcgtcgg cgcgggcatc gtgggcgccg
     5041 cctgcgcgtt ccacgccgtc gcggccggcc tcgacgtcac ggtgctcgac cggggccccg
     5101 tcggcgcggg cacgaccagc cggggcgagg gcaacatcct cctctccgac aaggagccgg
     5161 gacccgaact ggaactggcc cggctcagcc gcgatctgtg ggacgaggcc gcggaggaac
     5221 tcggcccgga gagcgtcgag ttcgagacca agggcggcct ggtcgtcgcg agcacgcccg
     5281 aagccctcac cgtcctgcac gcgttcgccg cgcggcaggc ggaatccggc gtccgtaccg
     5341 aacccgtcga gcgcccgggc gacctcgaac cgcatatcgc gcccggtctg cccggcggcg
     5401 tccactaccc gcaggacgcc caggtgcagc ccgttctcgc ggcggccggc cttctgcgcg
     5461 ccgccgtgcg ccgcggggcc cgtacgcaca ccggcgaggc cgccgccgcg gtcaccgccg
     5521 ccgacggccg gatcaccgga gtgcgtaccg ccgacggcac ggtgctgccc gccgacgccg
     5581 tggtcaacgc cgccggcacc tggggcggcg aggtcggccg ccggctcggc gcacccgtcg
     5641 agatcctgcc gcgccggggc ttcgtcctcg tcaccgaacc gctgccgccg atgatccggc
     5701 gcaaggtcta ctccgccgac tacgtcgcca acgtcgcctc cagcgacgcg ggtctggaga
     5761 cctcgtgcgt cgtcgagggc acccgcgcgg gcaccatcct gatcggcgcc agccgtgaac
     5821 gcgtcggctt cgacaccgcg atgaacccgg ccgtggtgac ggcgctcgcc gcccaggcat
     5881 gccgcctctt cccgttcctg cgcggcgtcc acctgatccg cgcctaccgg ggcttccggc
     5941 cgtactgccc ggaccatctg ccggtcgtcg gcccggaccc ccgcgtcccc ggcgtcgtcc
     6001 acgcgtgcgg ccacgagggc gccggcatcg gcctggcccc cgcgaccggc gccctggtca
     6061 ccgcccatct gctcggcaag ccctggcgcg gcgccgatcc ggccgcccac accggcctgc
     6121 tgccccaccg attcctcacc accggaggtg tgccgaagtg accgcaacga ccgcgttcac
     6181 cgtggacggc gagccgttgc cgttcgtccc cggacagacc ctggccgccg cgctcgtcgc
     6241 ctcgggccgg gtcgcctggc ggaccacccg gggcgggcag cggccccggg ggatcttctg
     6301 cgggatcggc gtctgcttcg actgcctggt gaccgtcgac ggtacgggcg gacagcgcgc
     6361 ctgtctggtc caggcccgtc cgggcatggc cgtcacgacc ggggaggacg gcgatgagtg
     6421 agtccggcga cctcgtggtg gtgggcgcgg gcccggccgg tctggccgcc gccgccaccg
     6481 ccctggacgg cggactgcgg gtcgtcctcg tcgactcggg ggccgctctc ggcggccagt
     6541 tctggcgcca cccaccgctg ccggcgcagg aggccgtgcc gaccgcggac ctccaccacg
     6601 gtctgggcgc ctaccgggag ttgtgcgcca cgctggccgc ccacgagcgc accggccggc
     6661 tcacgctgct gctgaaccac catgtgtgga ccacggcccg cgtggacgac ggattcgccg
     6721 tccacgcggt ggaccggagc cgggcacccg aggagcggac cgtcgtgctg cgcgccccgg
     6781 ccctgctgct ggcgaccggc gcctacgacc gccaactccc tttccccggc tgggacctgc
     6841 ccggtgtgct caccgtcgga gggcttcagg cgctgctcaa gggcggggga gtggtggccg
     6901 gccgccgggt ggtcctcggc ggtacgggcc ccttcctgct gcccgtcgcc gcggccctcg
     6961 ccgcgcgcgg ggccgaggtc gtcgcggtgt gcgaggcggc ggcgccctcg gcctggctgc
     7021 gccaccccgc ggccctgctc cgtaaccccg ccaagtgggc cgaggccgcc cggtacgcgg
     7081 gcaccctcgc ccggcaccgg atcccggtcc gcacccgtac cgcgatcatc ggcgccgaag
     7141 gaggagcaga aggacaggcc gaaggacagg ccggagtcgg ggcaggagca gagggccggg
     7201 tcgccttcgt ccgcaccgcc tccctggacg cggacggcaa ccccctgccg ggtacggagc
     7261 gccggatcgc ggccgacacc gtgggcgtcg gctggggctt cgtaccccag ctggaccttc
     7321 tgctcccgct cggctgcgcc ctcgccgacg cgggcgacgg caccatggcc gccgccgtcg
     7381 acgacggaca gcgcaccacg gtgcccgggc tctacacggc gggggagacc tgcggtgtgg
     7441 gcggggccgc gctcgcggtg agcgagggcc gcgtcgccgc cgtctcggtc ctcaccgacc
     7501 tctccgcgcc gggcctgccg aacgcccggc ggctcgccgc ggagcgccgg gcggtgatcc
     7561 ggcaccgcgc cttcgcccgg gcgatggcac aggcacaccc cctgccaccg gcctggcccg
     7621 cctggctcac cgacgacacc ccggtctgcc ggtgcgaaga ggtcaccgcg ggtgcggtcc
     7681 ggtccgcccg cgccgacgac gcggcggccg accaccggca ggtcaaacag ctgacccggg
     7741 ccggcatggg ctggtgccag ggccggatgt gcgggcccgc cgtgcactgc ctcgtggccc
     7801 gcgaccagcc ctacgccccc gccgagcggc tgatcgcgac tcccgtctcc ctcggtgcgc
     7861 tcgccgacgc cggcgagtcc actcccgatc ccgcctccga tcccacctga ggagttccca
     7921 tggaccgcac ctccccccgt acccggatgc cctggcacgg cgtcatcgtc gcgacgagcc
     7981 tccccttcgg ccaggacctc gccgtcgacc acggcgccta cggcgacaac gtcgcctggc
     8041 tcgccgaaca gggcctgcac ggcgtcgccc cgaacggctc gctgggcgag taccagaccc
     8101 tgacgtacga ggaacgcgac cgcgtcgtgg agaccgccgt ggcccacgcc cccgagggct
     8161 tcaccgtgat gccgggagtc ggggcgtacg gcgcgatcga ggcgcggcgg cacgccctgt
     8221 tcgccaagga cgccggctgc caggccgtca tgtgcctgcc gcccaacgcc taccgggccg
     8281 acgaccgcgc cgtcctggag cactacgcga tggtggcctc cgccggactt cccgtcaccg
     8341 cctacaacaa ccccatcgac accaaggtcg acctgcgccc ggagctgctg gccaaactgc
     8401 acgccgaggg cttcatcgtg ggcgtgaagg agttctccgg agacgtccgc cggtgctacg
     8461 cgatcaacga actcgccccc gatctcgacc tgatcatcgg caccgacgac accctcctgg
     8521 aggtcgccgt cgccggtgcc aagggctggg tcgccggcta cccccaggtc ttcccgcgcg
     8581 cctgcctcga cctctacaac gcctcactgg cgggcgatct cgacaccgcg ctgccgctct
     8641 accgcaggct ccactccgta ctgcgctggg acagcaggac cgagttcgtc caggcgatca
     8701 agctcggcca ggacatgatc ggccggaccg gcggagtctg ccgcccgccc cggcaggccc
     8761 tggacccgga gaccgaggcc gtcgtccgct ccgccaccca ggccctcatc gacgcggggg
     8821 tgaactgacg tgcgctcgaa ggtctgttac cacgcggtcg actcgcacac cgagggcatg
     8881 ccgacccggg tgatcaccgg cggggtgggc gtgctgccgg gcgcgaccat ggcggagcgg
     8941 cggcagcggt tcatggccga acgggacggg ctgcgcaccc tgttgatgtg cgagccgcgc
     9001 ggacacgcgt ccatgtccgg cgcgatcctc cagcctccga cccggccgga cgccgacttc
     9061 ggggtgctgt tcatcgaggt ctccggctgc ctgcccatgt gcggccacgg caccatcggc
     9121 gtggcgacgg tcctggtgga gacgggcatg gtcgaggcgg tcgaaccgga gaccctcatc
     9181 cgcctcgaca cccccgccgg tctcgtcacc gcgcgggtcg ccgtgcgcga cggccgcgcc
     9241 gagtccgtca ccctggagaa cgtcgcctcc tacagccacg cgctggacca ggtggtcgag
     9301 gtggcgggct tcggcccggt ccgttacgac atggcgtacg gcggcaactt ctacgccgtc
     9361 gtgcgcaccg aggacctcgg catccccttc gaccggtcgg agaaggggcg gctgctcgac
     9421 gcgggcctgg ccgtcatgaa ggcgatcaac gaacagaatc cggtggtcca tccggagaac
     9481 ccggccatcg acgtctgtca ccacgtctat ctggaggccc ccggatcgac cgccgagcac
     9541 tcgcggcacg ccatggcgat ccaccccggc tggttcgacc gctcgccctg cggtacggga
     9601 accagcgccc ggatggccca actgcacgcg cgggggctgc tgaaggccgg gcaggacttc
     9661 gtcaacgagt ccttcatcgg ctcccgcttc accggccgca tcctgggcga aagcacggtc
     9721 ggcgggcggc ccgccgtcct gccctccgtc accggccgcg cctggatcac cggaaccgcg
     9781 cagtatctgc tcgaccccac ggacccctac ccgacgggtt tcaccgtatg acggccgacc
     9841 ctgccgccgc ccattccacc ggcccttccg ccggcccttc cgccggcccg accgggacgg
     9901 cacgtccgta caccacgccg atccgaaccg ccgactggca caccgggggc gaacccttcc
     9961 ggatcgtgcc cgaggctccg ccggtcctga ccgggcccgg gctcaccgtc tccgagcggc
    10021 gtacggtcgc catcgccgac gcgggcgcgc agtggacccg ggccctgctg tgcggcgaac
    10081 cacgcggcca cgccgacatg tacggggcct tcctcgtccc gccggacgac gccggggccc
    10141 acctcggcgc gctcttctgg cacaaggacg gcttctccac ggcatgcggc cacggcacga
    10201 tcgccctcgg ctcctgggcc gtcgccaccg gactggtcgc cgcgccgccg gacggcacga
    10261 cggacgtcgt catcgacgtc ccgtccggcc gtgtgacggc ggccgtgcgc acggccggcg
    10321 gccgggtcgc ggacgtgacc ttcgtcaacg tccccggcca tgtccacgcg cgcggcgtcg
    10381 aggcggcgac ctcgtacggg agcctcgccg tggacatcgc cttcggcggc gcgatgtacg
    10441 ccgtgcttcc ggtggaccgg ctcggcctcg gcctgcgggt ccggccgggg gacgtcaccg
    10501 cgctcatcgc ggccggccgc gagatccgcg acgcgctgaa cgccgtccgg gccgccgaac
    10561 acccggacga cgaccggctg tccggcgtct acggaacggt cttcaccgag gaggccgccg
    10621 ccccggtcga actcccggac ggcaccggac ggttgcacca ccgcaacgtc acggtgttcg
    10681 cggacggcca ggtcgaccgc tcgccgtgcg gctcgggcac cgcggcccgg gtggcgctcc
    10741 tcgccgacgc cggggaactg cgccccggcg acgaactgcg gcacgagtcg gtggtgggct
    10801 ccgtcttccg cgcccggatc gagcggacgg tcacggtcca cggccggccc gcggtcgtcc
    10861 cggccgtgac gggcaccgcg tacgccaccg gaaccggccg cttcaccgtc gatcccgacg
    10921 acaccctcgt acccgggttc gtgctgcgat gacggtgacg ctcgacgcgg cggacgtgtc
    10981 cgcgctcggt ccggtggccg ccgtcgccgc ggtccgggag gcgctggccg cagggctcga
    11041 cccggacggt gacgtaccgc gggcggtggt gccgctggcg cacggtcagg ggctgctcat
    11101 gccctccgag cacggcggct ggtacggagt gaaggtcgcc accgtcgcgc cgggcaacgc
    11161 cgcgcgcggc ctgcggcgga tcaacgccac gtatctgctg cacgacagcg cgaccctgac
    11221 gccggtggcc ctgctggacg gggtggcgct gacgaccctg cgcacccccg ccgtctcggt
    11281 cgcggccggc ctggagcggc tgcgcgcgct cgcggccgga tgcgaggacg gggacgagga
    11341 ccgggggctg cgactggtgg tgttcggcgc cggcccccag ggggaggggc acgtcgccac
    11401 cgtacgggcc catgtgccgg tggccgacgt cgcggtcgtc acccggcgcg gaggacccgt
    11461 ccccggctgg gcggaccggc gcctggcggc ggacgacggg ggagtggcgg ccctggtgcg
    11521 gcgggcggag gccgtcgtca ccgcgacgtc cgcgcgtcgg ccggtggtcg acgggcggct
    11581 ggtgcgcgac gacgcggtgg tcctggcggt cggctcgcac gaaccggacg tacgggagct
    11641 cgacagcgtg ctgatggggc gcgccaccgt cgtggtggag agccgtgaga tcgccctccg
    11701 ggaggcgggc gacgtcgtcc tggcgatccg cgaggacatg ctcgccccgg acgacctgct
    11761 caccctggcg gatctgcccg gcgcccgggc cgccgccgtc ccggccgacc gcccgctggt
    11821 cgtgaagacc tgcggggcgg gctggcagga cctggtgatc gcggtcgcgg cctaccggcg
    11881 gaaggtgggg gtagtggtca agcgcggctg aggtgggcgc ccgggcatcg gcctcgacgc
    11941 gcgccgcgtt cggcggactt cggcatcagc gaacgccacc gcgtcgggcc tcggcctgaa
    12001 cgcccgccga ctgcacaggg gttacgcgtc agcgcgcgcc gccccgtcag gcctccgcct
    12061 caacgcaccc cgcccccacc ggacgtccgc gtcagcgcgc gccgagcttg cgggtcggtg
    12121 cggcgcgttc ggcctcccgc ttccgggccg cccacagcgt ccgcacatgc gcgagatggc
    12181 cgcgcatgtg cgcctcggcc gcctccgcgt ctcccgcgat catgatgtcc aggagcgcgg
    12241 tgtgctcccg cgccgaactc accagcgacc cttcctcgga cagatcggtg agcccgtaga
    12301 gccgggagcg cttgcgcagg tcggccacgg tctcgacgag gcgggtgttc ccggcgaggg
    12361 cgagcagttc gagatggaag cgccggtcgg actccagata ggcgatcagg tcgccgccct
    12421 gcgcggccgt cacgatctcc tcggccaccg ggcgcagcgc ctccagctgc tcgcgggagg
    12481 cggtgcgggt cacgcggccg atggtgggga tctcgatgag cgcgcggatc tcggtgtact
    12541 cgtccaggtc gcgctcggag agttcggtga cccggaagcc cttgttgcgc accgcctcga
    12601 ccagaccctc gcgggccagg tcgagcatgg cctcacgcac gggcgtcgcc gagacgccgt
    12661 actcggcggc gagggtgggc gcggagtaga tcacgccggg ctgcagctca cccgctatca
    12721 gagcggcccg cagtgcgttg gccacctggt cgcgcagatg ctcctgcacc gagatgagtt
    12781 tgcgggactt cagctcactc atgcgttccc cttcacgatt tgtcaccgca ccatacaatg
    12841 tcacgttgcg cggcgacgcg gcaccctccg gagggtggtc gaggggcgcg gagaccggcg
    12901 aacggccagg
//
