LOCUS       NZ_JALDPQ010000059     10798 bp    DNA     linear   CON 28-MAY-2024
DEFINITION  Streptomyces sp. TRM75563 730, whole genome shotgun sequence.
ACCESSION   NZ_JALDPQ010000059
VERSION     NZ_JALDPQ010000059.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TRM75563
  ORGANISM  Streptomyces sp. TRM75563
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 429529)
  AUTHORS   Chen,Y.
  TITLE     Streptomyces aheensis sp. nov., isolated from road
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 429529)
  AUTHORS   Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2022) College of Life Science, Tarim University,
            Hongqiao, Alar 843300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 14-MAR-2022
            Assembly Method                   :: ABySS v. V2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022748615.1-RS_2024_05_28
            Annotation Date                   :: 05/28/2024 05:18:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,476
            CDSs (total)                      :: 7,413
            Genes (coding)                    :: 7,165
            CDSs (with protein)               :: 7,165
            Genes (RNA)                       :: 63
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 249
            CDSs (without protein)            :: 248
            Pseudo Genes (ambiguous residues) :: 1 of 249
            Pseudo Genes (frameshifted)       :: 108 of 249
            Pseudo Genes (incomplete)         :: 202 of 249
            Pseudo Genes (internal stop)      :: 19 of 249
            Pseudo Genes (multiple problems)  :: 75 of 249
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:22:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 339741
            Orig. end                         :: 350539
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALDPQ010000059.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10798
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10798
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10798
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5798](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5798
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            1065..1607
                     /locus_tag="MQC87_RS14230"
                     /old_locus_tag="MQC87_14230"
     CDS             1065..1607
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955650.1"
                     /locus_tag="MQC87_RS14230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_14230"
                     /product="DUF5709 domain-containing protein"
                     /protein_id="WP_103508936.1"
                     /transl_table=11
                     /translation="MSDTDWGDDVYQPQEPEASDPGEQLGAEDTLMDPSGTGDPLDEGY
                     SPPDRPWVVDGLGTTADERNTGESLETRLTREVPEPDGSAGDGVGDLVDGDGEPWDDEV
                     GVARAGRLTQQADGRVPATLTASDVGIDGAAASAEEAAMHVIPEPGDDDALLEAGPPPA
                     APGSGPAGGGTAAPPPS"
     gene            1756..3195
                     /gene="gndA"
                     /locus_tag="MQC87_RS14235"
                     /old_locus_tag="MQC87_14235"
     CDS             1756..3195
                     /EC_number="1.1.1.44"
                     /GO_function="GO:0004616 - phosphogluconate dehydrogenase
                     (decarboxylating) activity [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="gndA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006141148.1"
                     /locus_tag="MQC87_RS14235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_14235"
                     /product="NADP-dependent phosphogluconate dehydrogenase"
                     /protein_id="WP_242739374.1"
                     /transl_table=11
                     /translation="MSGTAQIGVTGLAVMGRNLARNFARNGFTVAVHNRTTSRTDALVE
                     EFGDEGTFVAAHTPEEFVAALERPRRLVIMVKAGDPTDAVIQEFAPLLEEGDVIIDGGN
                     AHFEDTRRREKELRERGIHFVGVGISGGEEGALNGPSIMPGGSAESYASLGPMLEKIAA
                     QAKDGTPCTTHIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRAVAGYSPAQIADVFR
                     TWNTGRLDSYLIEITAEVLAHTDAATGKPFVDIVQDRAEQKGTGRWTVQIALNLGVPVS
                     GIAEAVFARSLSGHADLREAARDLPGPTPKPLDGAAAAAFADQVEQALYASKVVSYTQG
                     FHQIRAGGETYDWDIDLGSVAAIWRAGCIIRAAFLDRIRAAYDSRPDLVSLLSDKEFGQ
                     EIGAAQDDWRAVVAEAVRQGVPTPGFAAALSYYDGLRADRLPAALTQGQRDFFGAHTYR
                     RTDREGSFHTLWGGDRTEVES"
     gene            complement(3263..3679)
                     /locus_tag="MQC87_RS14240"
                     /old_locus_tag="MQC87_14240"
     CDS             complement(3263..3679)
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013625.4"
                     /locus_tag="MQC87_RS14240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_14240"
                     /product="peptidoglycan-binding domain-containing protein"
                     /protein_id="WP_242739376.1"
                     /transl_table=11
                     /translation="MALTATRRRTAIVFASLVLLGGTATGGVAAAAGTGAAAAAAYPCD
                     VKMSSAGRLSAGYYDGNTVVPSTSQVTAAGKEAQCLLQYQGHNPGTIDGIFGRNSQAAA
                     KKFQKGVNYACRTTLAEDGQVGRQTWPYLRRLYC"
     gene            3928..5001
                     /locus_tag="MQC87_RS14245"
                     /old_locus_tag="MQC87_14245"
     CDS             3928..5001
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007456253.1"
                     /locus_tag="MQC87_RS14245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_14245"
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_242739378.1"
                     /transl_table=11
                     /translation="MPDAVPDPVSVQPVVAPLTSAALFLVGTIEPGGEGAVRDVLPDLA
                     AVARSLGFRYPDSGLACVAGFGSSAWDRLFAGPRPAHLHPFPELRGPLHHAPATPGDVL
                     LHIRAERMDVCYAWAAQLLDKLGGALRIVDETHGFRYLDHRDLLGFVDGTENPVGDDAR
                     SAALVGADDDPDFEGGSYVVVQKYLHDLTSWNALSVEEQERVIGRTKLDDVEFPDEDKP
                     ADSHLALNTITDPDGTERDILRANMPFGSFGKGEFGTYFIGYAADPDVTERMLRNMFLG
                     DPPGTHDRILDFSTAVTGSLFFAPRADFLDAPPPLPVVARSGDRPEPVPVPVRQEAVAA
                     GPDHGSLRIGSLQESAP"
     gene            5001..5798
                     /locus_tag="MQC87_RS14250"
                     /old_locus_tag="MQC87_14250"
     CDS             5001..5798
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955648.1"
                     /locus_tag="MQC87_RS14250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_14250"
                     /product="family 1 encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_242739380.1"
                     /sec_met_domain="Linocin_M18 (E-value: 5.2e-89, bitscore:
                     292.3, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLHRELAPVTPSAWDEIEEEARRTFRRHVAGRRVVDVSDPDGP
                     TLSAVGDGHLRDIDPPTPDVVARARTSMPVIEWRVPFTVTRQAVDDVERGSADSDWQPV
                     KDAARTCAFAEDMAIIDGYGAAGITGLRDGSSHEPLPLPADARDYPVAVSQAVTRLRLA
                     GVDGPYRLLLGADAFTEAAETSDHGYPVKTHLSRLVDDEILWAPAVKGGVLLSTRGGDF
                     ELCLGQDLSIGYADHDTTSIHLYFQQAFTFRMLTPEAVVGLIA"
     gene            5831..7207
                     /locus_tag="MQC87_RS14255"
                     /old_locus_tag="MQC87_14255"
     CDS             5831..7207
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_DAP_Arg_deC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264: diaminopimelate decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007456256.1"
                     /locus_tag="MQC87_RS14255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_14255"
                     /product="diaminopimelate decarboxylase"
                     /protein_id="WP_242739382.1"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 1.7e-39, bitscore:
                     130.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 9.5e-09,
                     bitscore: 30.1, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQTTSAPHHEDGTAPPAARFDAVVKAAVQQGLLGEGGPVAGFID
                     TEGVRASVGTLRDAFAGPPEVLHTFAAKACSLIPVLRLLADRGMGCEVASPGELRLALE
                     AGFPTSRIVLDSPAKTREEIRLALALGVAVNADSLDELRRIDALRNPGSASVLGLRVNP
                     QVGGGAIGPMSTATDTSKFGVALRDPGAREAIVAAFRERPWLTRLHAHVGSQGCPLELI
                     AAGVAQTYELAEEINATLGVRQVTSLDIGGGLPVNFADETVHPTYADYVAALTAAAPGL
                     FSGRYALVTEFGRSLLAKNGFIGARVEYTKDAGGRRIALTHAGAQTATRTVLMPDAWPL
                     RIGAFGPDGTPKGGPVLAQDIAGPCCFAGDVVAYGRELPELAQDDVVVLYDTGAYYFST
                     PWAYNSLPRPAVYGFRVAAEAGRDRTAVTFATVRDAQSIEAIAAESGLAHADALVERSD
                     "
     gene            complement(7364..7570)
                     /locus_tag="MQC87_RS14260"
                     /old_locus_tag="MQC87_14260"
     CDS             complement(7364..7570)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MQC87_RS14260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MQC87_14260"
                     /product="hypothetical protein"
                     /protein_id="WP_078611318.1"
                     /transl_table=11
                     /translation="MTHPYPDPVPPSPTPPPVPGPPTPVPGPPPVPPGPGPVPPGPAPD
                     PIPQPPGPDPVPDPEPEPQPAGT"
     gene            7783..8553
                     /locus_tag="MQC87_RS14265"
                     /old_locus_tag="MQC87_14265"
     CDS             7783..8553
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955646.1"
                     /locus_tag="MQC87_RS14265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_14265"
                     /product="PIG-L family deacetylase"
                     /protein_id="WP_242739384.1"
                     /sec_met_domain="PIG-L (E-value: 8.4e-23, bitscore: 76.1,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLPSVLAVHAHPDDESLFCGGVLAQHAASGARTAVVTATWAPGT
                     HRAAELGRALDALGAGAPRLLGYADARVPESAPGRPRFLDAPLDEAVEAVVGHIRDVRP
                     EVVITVDAYGGMTGHPDHVHAHRITALAVRAAGLPRYGPRAGDPWQPSALHLATHPRSA
                     AVPVGGRLARAGTPADALYCSEDAWITTTVDVGPWLPQKLAAILAHRSEVERGAAPGRI
                     AALSPAVQREVLGTEWYIRQDLTPRSGSATELSA"
     gene            complement(8580..8933)
                     /locus_tag="MQC87_RS14270"
                     /old_locus_tag="MQC87_14270"
     CDS             complement(8580..8933)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955645.1"
                     /locus_tag="MQC87_RS14270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_14270"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_242739386.1"
                     /transl_table=11
                     /translation="MAENAAVEIRDDREHGTLVAYEDGTSAGTIAYFVMDPAPGALVAV
                     HTVVRPEHEGKGIAGALVREFYAMAAREGVPVVPLCPYAAKWAQRHPDEAPEAPGELVR
                     EAGRQLRHHPELF"
     gene            complement(8999..9424)
                     /gene="panD"
                     /locus_tag="MQC87_RS14275"
                     /old_locus_tag="MQC87_14275"
     CDS             complement(8999..9424)
                     /EC_number="4.1.1.11"
                     /GO_function="GO:0004068 - aspartate 1-decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0015940 - pantothenate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="panD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964661.1"
                     /locus_tag="MQC87_RS14275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_14275"
                     /product="aspartate 1-decarboxylase"
                     /protein_id="WP_242739388.1"
                     /transl_table=11
                     /translation="MLRTMFKSKIHRATVTQADLHYVGSVTIDAALMEAADLLPGELVH
                     IVDIDNGARLETYVIEGERGSGVIGINGAAAHLVHPGDLVILISYAQVDDAEARALVPR
                     VVHVDADNRIVALGDDASAPVPGSRTERSPQAVVADV"
     misc_feature    complement(9722..9737)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     misc_feature    complement(10236..10247)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.69"
                     /tool="antismash"
     misc_feature    complement(10668..10684)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.04"
                     /tool="antismash"
ORIGIN
        1 gtaggagcag ccgcccgtcc ggccgacacc ggtcgaggtg gccgtcgcca cgctcccggt
       61 gatgccggac ttcgtcgtga acggcttcgc cgccccggtg gtgacctttt ccttcgacgg
      121 ctgggcgtag ctgccataga cccacaggcg ggcgttctcc cgggccgctt cggcggtgct
      181 tcgggcgccc ggctcgcccc gggagcccgc ggcggcgagc ggggtgtcct cccgggcgcc
      241 gttgccgtcg tcgtcggacc ggcaccactt ctcctggagg atcgccgggg ccgagaaccc
      301 gacgagcggc ttctcgtcgc ggtcgtcgtt cgcggcgacg taactcaccc agccggtcga
      361 cttgagcgcc catgggacgg ggacgtcgaa ggcgatgccg cgcttggggt tgaccacggt
      421 cttccagccg ggcacgaggg gcgcggtccc gttctccgca ccgccccgcg cctcgcccgg
      481 ggacgccgac ggtgccacgg tgtccgtccc ggcgggtccc gcgaccggct tcccgtcgtc
      541 ctctccgccg ccgagcacca ggaatccggt gattccggcg gcgagcacga cgggggcggc
      601 ccggagggaa cggtctgcgc gctccagggg gcggatgcgg gctgcccggc gggttcggtg
      661 cgcgcgtccc acggggcggt cccggctccc gcgtacggcg gctgcccgcc ggcctgctgc
      721 tcccgcggcg gccacccgta cggctgctgc ccctggccct gtccgtacgg ctgcggctga
      781 tcctgctggt ggtgatcgcc cccgggcgac tgctgtccgt tccccatggg ccaccacccc
      841 atgcccagcc gttcgacgat tcgaacaccc tgtgcccgga ctcccacgag ctcctcatat
      901 gcgcggcgaa acggccgcga cctgcgtacg gaccggttcg catcgcctga gcccggcccc
      961 ggaaaccgat cttccctttg cggccggagc gggacgggag tggaattgcg tacaggggac
     1021 aggagaaccc gtcactcccg gacgaccgga ggaaaggacg cgccatgagc gacaccgact
     1081 ggggggacga cgtctaccag ccccaggaac ccgaggcttc ggatcccggc gaacagctcg
     1141 gcgccgagga cacgctcatg gatccgtccg gcaccggcga ccccttggac gaggggtatt
     1201 cgccgccgga ccgcccgtgg gtggtcgacg gactcggcac cacggccgac gagcggaaca
     1261 ccggagagtc cctcgaaacg cggctgacca gggaagtgcc cgagccggac ggttccgccg
     1321 gcgacggtgt gggcgatctg gtggacggcg acggagagcc ctgggacgac gaggtgggcg
     1381 tcgcccgcgc cgggcggctc acccagcagg ccgacgggcg cgtcccggcc accctcaccg
     1441 ccagtgacgt gggcatcgac ggtgcggcgg cgtcggccga ggaggccgcg atgcatgtga
     1501 tccccgagcc gggggacgac gacgcgctcc tggaggccgg cccacccccc gccgccccag
     1561 gttccggccc cgccggcggc ggcacggcag ccccgccgcc gtcctgagcg gaccggcggc
     1621 gagcgctcgc cctgaacgcg gcagtccccg ggcccgtact cccctgaccg aagcgcacac
     1681 cggccagcac gcacaccccc gaaccgcacg catccaccgc acgcaccgac gtactcgcac
     1741 cccaggagcg caccaatgag cggcaccgcc cagatcggcg tcaccggact cgcggtcatg
     1801 ggccgcaacc tggcccggaa cttcgcccgc aacggcttca ccgtcgccgt gcacaaccgc
     1861 accacgtccc ggacggacgc cctggtcgag gagttcggcg acgagggcac gttcgtcgcc
     1921 gcgcacacgc ccgaggagtt cgtcgccgcg ctggagcggc cccggcgtct ggtgatcatg
     1981 gtgaaggcgg gagaccccac cgacgccgtg atccaggagt tcgcgccgct gctggaggag
     2041 ggcgacgtca tcatcgacgg cgggaacgcc cacttcgagg acacccgccg ccgtgagaag
     2101 gagctgcgcg agcgcgggat ccacttcgtc ggggtgggga tctccggtgg cgaggagggc
     2161 gcgctgaacg gaccgagcat catgccgggc ggctcggcgg agtcctacgc gtcgctgggc
     2221 ccgatgctgg agaagatcgc cgcgcaggcg aaggacggca cgccgtgcac cacgcacatc
     2281 ggtccggacg gcgcgggcca cttcgtgaag atggtgcaca acggcatcga gtacgcggac
     2341 atgcagctga tcgccgaggc gtacgacctg ctgcgcgcgg tggccgggta ctcccccgcg
     2401 cagatcgccg acgtcttccg tacgtggaac accggccggc tggattcgta tctgatcgag
     2461 atcacggcgg aggtcctcgc ccatacggac gcggcgaccg gaaagccgtt cgtcgacatc
     2521 gtgcaggacc gggcggagca gaagggcacc gggcgctgga ccgtacagat cgcgctcaac
     2581 ctcggggtcc cggtgtcggg catcgcggag gcggtcttcg cccggtcgct gtccggccac
     2641 gccgatctgc gggaggcggc ccgcgatctc cccgggccca ccccgaagcc gctggacggg
     2701 gcggcggcag cggcgttcgc ggaccaggtg gaacaggccc tgtacgcctc caaggtcgtc
     2761 tcgtacacgc agggtttcca ccagatcagg gcgggcggcg agacctacga ctgggacatc
     2821 gatctcggct ccgtggcggc gatctggcgg gcgggctgca tcatccgggc ggcgttcctc
     2881 gaccgcatcc gcgccgccta cgactcccgg cccgacctgg tcagcctgct ctccgacaag
     2941 gagttcgggc aggagatcgg cgcggcgcag gacgactggc gggcggtggt ggccgaggcc
     3001 gtacgccagg gcgtgccgac cccgggcttc gccgccgcgc tctcgtacta cgacgggctg
     3061 cgcgcggacc ggctgcccgc ggcgctcacc cagggacagc gggacttctt cggggcgcac
     3121 acctaccggc gcacggaccg ggagggctcg ttccacacgc tctggggcgg cgacaggacc
     3181 gaagtggaga gctgacccgt ccgcccctgc gcccgacccg cacaggggct gatgcgcgca
     3241 ggagttgatg cgctgcggag gatcagcagt agagccggcg caggtagggc caggtctgcc
     3301 ggccgacctg accgtcctcg gccagggtgg tgcggcaggc gtagttgacg cccttctgga
     3361 acttcttcgc cgcggcctgg gagttgcggc cgaagatgcc gtcgatcgta cccgggttgt
     3421 ggccctggta ctggagaagg cactgggcct ccttgccggc ggcggtcacc tgcgaggtgg
     3481 aggggacgac ggtgttgccg tcgtagtagc cggccgagag ccggccggcg gagctcatct
     3541 tcacgtcgca cgggtaggcc gcggcagcgg cggcgccggt cccggccgcg gcggcgacgc
     3601 cgccggtggc cgtacctccc agcaggacga gggaggcgaa cacgatcgcg gtgcgcctgc
     3661 gggttgcggt gagtgccatg gaagaactcc tgagagggtg cgtggtcggt atcgcccggc
     3721 cgtgggtgcc tgccggtcgg gcacacccga ctgtcttgcg aacacggctg ccccgggtac
     3781 ctcgaacagt tcaggttgca caacccaccg atcgtcggct accgacccat tgccgctgac
     3841 ccgcacggtc caccccgggt gcggccggcc gcagggcgtg gcctagtagc tgcgagtcct
     3901 gttcgccgtt cgtagtggag tgcgcgcatg cccgacgccg tgcctgaccc cgtctccgtc
     3961 cagcccgtcg tggcgccgtt gaccagcgcg gcgctgttcc tggtcggcac gatcgagccg
     4021 ggcggcgaag gcgcggtgcg ggacgtgctg ccggatctcg cggccgtcgc ccggtcgctc
     4081 ggattccggt acccggactc cggcctcgcc tgtgtggcgg gcttcggctc cagcgcctgg
     4141 gaccggctgt tcgcggggcc acggcccgcg cacctccacc cgttcccgga gctgcgagga
     4201 cctctgcacc acgccccggc gaccccgggt gacgtgctgc tgcacatccg ggccgagcgg
     4261 atggacgtct gctacgcgtg ggcggcccag ttgctcgaca agctcggcgg ggccctgcgg
     4321 atcgtggacg agacgcacgg cttccgctac ctcgaccacc gggatctgct cggcttcgtg
     4381 gacggtacgg agaacccggt cggcgacgac gcccgttcgg cggcgctcgt cggcgcggac
     4441 gacgacccgg acttcgaggg cggcagctac gtcgtcgtac agaagtatct gcacgacctg
     4501 acgtcctgga acgcgctgtc cgtcgaggag caggaacgcg tcatcggccg caccaagctc
     4561 gacgacgtgg agttccccga cgaggacaag cccgccgact cccacctcgc gctcaacacc
     4621 atcaccgacc cggacggcac cgaacgcgac atcctgcggg cgaacatgcc gttcgggagc
     4681 ttcgggaagg gcgagttcgg tacgtacttc atcgggtacg ccgccgatcc cgacgtgacc
     4741 gagcggatgc tccgcaacat gttcctcggc gatccacccg ggacgcacga ccgcatcctc
     4801 gacttctcca ccgcggtcac gggctcgctc ttcttcgccc cccgcgccga cttcctcgac
     4861 gctccgccgc ccctgcccgt cgtggcccgc tccggggacc ggccggaacc ggtgcccgta
     4921 ccggtccggc aggaagcggt cgcggccggt cccgaccacg gttcgctgcg catcggcagc
     4981 ctgcaagaaa gtgccccgtg atgaacaatc tgcaccgcga actcgcaccg gtcaccccgt
     5041 ccgcctggga cgagatcgag gaggaggccc gccgcacctt ccgccgccat gtcgccggcc
     5101 gccgtgtcgt cgacgtgtcc gatccggacg gccccacgct gtccgccgtg ggcgacggcc
     5161 atctgcgcga catcgatccg cccaccccgg acgtggtggc gcgggcccgc acctcgatgc
     5221 cggtcatcga gtggcgggtg ccgttcacgg tgacccgcca ggccgtggac gacgtggagc
     5281 gcggctccgc cgacagcgac tggcagcccg tcaaggacgc ggcgcgcacc tgtgcgttcg
     5341 ccgaggacat ggcgatcatc gacgggtacg gggcggccgg gatcaccggc ctgcgggacg
     5401 gttcctcgca cgagccgctg ccgctgcccg ccgacgcgcg ggactatccg gtggcggtca
     5461 gccaggccgt gacacggctg cggctggccg gtgtcgacgg accgtaccgg ctgctgctcg
     5521 gcgcggacgc gttcaccgag gccgccgaga cctcggacca cgggtatccg gtcaagacgc
     5581 atctgagccg cctggtggac gacgagatcc tgtgggcgcc cgcggtcaag ggcggggtgc
     5641 tgctcagcac ccggggcgga gacttcgaac tctgcctggg ccaggacctg tcgatcggct
     5701 acgcggacca cgacaccacc agcatccacc tctacttcca gcaggccttc accttccgga
     5761 tgctgacgcc ggaggccgtg gtcggtctga tcgcctgacc ctgggggcag ccatcaggga
     5821 ctctgaccgt atgacgcaga cgacttccgc accacaccac gaggacggca cggccccgcc
     5881 cgccgcccgc ttcgacgccg tcgtcaaggc ggccgtccag caggggctgc tgggcgaggg
     5941 cggcccggtc gccggattca tcgacacgga gggggtgcgc gcctccgtcg gaaccctgcg
     6001 cgacgccttc gccggcccgc ccgaggtact gcacaccttc gcggccaagg cctgttccct
     6061 catcccggtg ctgcggctgc tcgccgaccg cggcatgggc tgcgaagtgg ccagccccgg
     6121 tgaactgcgg ctggccctgg aggccgggtt ccccacctcc cgtatcgtcc tggactcccc
     6181 cgccaagacc cgcgaggaga tccggctggc gctcgccctc ggcgtggccg tcaacgccga
     6241 cagcctcgac gaactgcgcc gcatcgacgc cctccggaac ccgggctccg cctcggtact
     6301 cgggctgcgg gtcaaccctc aggtcggcgg tggcgcgatc gggccgatga gcacggcgac
     6361 ggacacctcc aaattcgggg tggcgctgcg cgacccgggg gctcgcgagg cgatcgtggc
     6421 ggccttccgg gaacggccgt ggctgacccg gctgcatgcc catgtgggct cccagggctg
     6481 cccgttggag ctgatcgcgg cgggggtggc acagacctac gaactggccg aggagatcaa
     6541 cgcgacgctg ggcgtccggc aggtcaccag cctcgacatc ggcggcggac tcccggtcaa
     6601 cttcgccgac gagaccgtgc accccaccta cgcggactac gtggcggccc tgacggcggc
     6661 cgcccccggc ctcttctccg ggcgctatgc gctggtcacg gagttcggcc ggtcgctgct
     6721 ggcgaagaac gggttcatcg gggcccgggt ggagtacacg aaggacgccg ggggccgccg
     6781 tatcgcgctc acccacgcgg gagcgcagac cgcgacccgt accgtcctca tgcccgacgc
     6841 ctggccgttg cggatcgggg cgttcggccc ggacggcaca ccaaagggcg gcccggtgct
     6901 ggcgcaggac atcgcgggac cgtgctgctt cgccggcgac gtggtggcgt acggcaggga
     6961 gctgccggag ctggcccagg acgatgtggt ggtgctgtac gacacggggg cgtactactt
     7021 ctccaccccg tgggcgtaca acagcctccc gcggccggcg gtgtacgggt tccgggtggc
     7081 ggcggaggca gggcgcgaca ggacggcggt gacgttcgcg acggtgcggg acgcgcagtc
     7141 gatagaggcc atcgcggcgg agagcggcct cgcgcacgcg gacgcgctgg tcgagcggag
     7201 cgactgaccg gggcggatgc ctgggaacgt acagccgccc ggcactccgg ccctccggcg
     7261 cccctcggcg tcaccgcggt gggccggtgc gggaccgaga agcgccgggc gacagtcggt
     7321 cagcgccgcc gaggccggca ccgtcaccgg taccggcccc cgctcacgtc ccggcgggct
     7381 ggggctcggg ttccggatcc ggtacggggt cggggcccgg cggctgcggg atcgggtcgg
     7441 gcgcggggcc gggcggaacg ggcccgggac ccggcggcac gggcggcgga ccgggcaccg
     7501 gggtgggcgg gcccggtacg ggcggaggcg tcggcgaggg cggtacgggg tcggggtacg
     7561 ggtgggtcat cgcgatcctc cacaacggca cggaaaggac agatggagct ttcctccacc
     7621 gtctcccggt gcggctgccc gcgcctgccg agtccacaca tgcgcccggc gacggcaacg
     7681 cacacggccg ggtgcgttgc ccgcccggag tgggcagcac tccgggggcc ccggccccgt
     7741 ccgggatcca cgaccggcac cgtcgacacg aaaggcgtcc ccatgtctct gccgagcgtc
     7801 ctcgccgtcc acgcccatcc ggacgacgag tccttgttct gcggaggcgt actggcccag
     7861 cacgcggcat ccggcgcccg cacggcggtg gtcaccgcga cctgggcgcc gggcacacac
     7921 cgggccgccg agctgggccg cgccctggac gccctgggcg cgggcgcccc gcgcctgctc
     7981 ggctacgcgg acgcccgggt accggagtcg gcaccgggca ggccccggtt cctcgacgcg
     8041 ccgctggacg aagccgtgga ggcggtggtc ggccacatcc gggacgtccg gccggaggtc
     8101 gtgatcacgg tggacgccta cgggggcatg accggccacc cggaccacgt gcacgcccac
     8161 cggatcaccg cgctggcggt ccgggccgcc gggctccccc gctacggtcc acgagccggt
     8221 gatccctggc agccgagcgc gctccacctc gccacgcacc cccgctcggc ggccgttccg
     8281 gtgggcggac ggctggcccg ggcgggcacc ccggccgacg cgctgtactg ctcggaggac
     8341 gcgtggatca ccacgaccgt cgacgtcgga ccctggctcc cgcagaagct ggccgcgatc
     8401 ctcgcgcacc gcagcgaggt ggaacgagga gcggcaccgg gccggatcgc cgctctgtca
     8461 ccggcagttc agcgggaggt gctgggcacc gagtggtaca tccgccagga cctcacgcct
     8521 cggagcgggt ccgccacgga gctgagcgcc tgacggcgag ctcgatgcgg acggagggct
     8581 cagaacagct caggatggtg cctgagctgc cgccccgcct cccggacgag ctcgcccggc
     8641 gcctcgggcg cctcgtcggg gtggcgctgc gcccacttcg ccgcgtacgg gcacagcggc
     8701 acgacgggaa cgccctcgcg ggcggccatg gcgtagaact ccctcacgag cgcgcccgcg
     8761 atgcccttgc cctcgtgttc gggccggacc acggtgtgca cggccacgag cgctccggga
     8821 gccgggtcca tgacgaagta cgcgatggtc ccggccgacg taccgtcctc gtacgccacg
     8881 agggtgccgt gctcccggtc gtccctgatc tccactgccg cgttctccgc catggctcct
     8941 gccctctcgt tcgtggaccg cgcacaccgt gctcgtcccg gaagcgcgga cggcggcctc
     9001 agacgtccgc gacgacggcc tgcgggctcc gctccgtacg gctccccggt accggcgccg
     9061 aggcgtcgtc accgagtgcc acgatccggt tgtccgcgtc cacgtggacg acccgcggca
     9121 cgagtgcacg ggcctcggca tcgtcgacct gcgcgtagct gatcaggatg accaggtcac
     9181 cggggtgcac gaggtgtgcg gccgcgccgt tgatcccgat gacaccggag ccgcgctcgc
     9241 cctcgatgac gtacgtctcc aggcgtgcgc cgttgtcgat gtcaacgata tggaccagct
     9301 cgccgggcag caggtcggcg gcctccatca gggcggcgtc gatcgtcacg gatccgacat
     9361 agtgcaggtc ggcctgggtg acggtggccc ggtgaatctt tgacttgaac atggtgcgca
     9421 gcatggggac tcctctgaga cggctccctg cctgctttgt gcaggtcaag ggctgtctcg
     9481 actgtacacc ggcacacgcc gaacgatgtt cgtgaagaac atcgcgctgg tcaggcgata
     9541 cgggccctca cctgggctct cgtgccgtca ccgacgctag tccagccaat cctccgggaa
     9601 tgcctggcga ctcatgctga ccgaacgctg actttcctga tcgctcgtca ggtggagctc
     9661 cggagaaccc actcaccctc ccgagctccg cgaagactcc gcagctctcg ccgcaggcat
     9721 ccgtgatcgc cgtcaccccg acgggcgacc acgtgggagt tccatgcggt gctgcaacct
     9781 agtagcgaat cgcggtacag caaagtcgct gaatctcgca ccatggccat ggcctgcgcg
     9841 acgactcttc gagggcacca ctctggcggg gcatcggcac cgcccacgtc cctgacaccg
     9901 ccgttcccgg cgagtgggga aatgctggtc ggcgccagcc gccaggccaa gctgctcagc
     9961 ggccctggca aggactggac tcgcctgcac gcacacctgg cggccacccc ggcggccggt
    10021 gaccgacgtg cggggaggtg gccaccgtga tcggcagcca cgccgtccca gtcggcaccc
    10081 ttctggtttt ctgcggccag tgccttaacg catggcgggt cctccacgca gcggccgcgt
    10141 cagccccggc ttccgcgggc cgccccccct cgcacagagt cacccgccga tgtcctgtcg
    10201 gccgacggca tccgcttcga cgggcatcgc cccccgttac ctttttcgtg gctccgcaat
    10261 ggggcctccg gcctacgggt ccggtatgac ctccccctac tgttgttgat gatcgggggg
    10321 tggtgtcacc gggcccggtg gcatcgacgg accgctgatg aggggcttga gcaccggctt
    10381 cacccaggcc ggaagagctc tccatgatgt ggatgtggca gctcggtgcc gtggcaaggc
    10441 cggacgaaag cgcgatggaa gggtggggcg aggcgttctc cggggtcgcg aagaacgtct
    10501 tccatcatct gttgtgcttc gccaccgtgt gtggcagctc gggctgttgc ggaatgcctg
    10561 gcacgcctcc atgaacttcg tcatccgcgc agcaggtcac cgggccccac ctgagcacac
    10621 agagagggct ccgcttctcc ctcgtatgcc agatggagtt catgtcgtgc ccgggttgcc
    10681 agcacgtaat aggtcatgcg caaggcagcc gacgtgggat ccaccgccgc gtccgtatgc
    10741 gtgtcgggga tgacgacggt gtcgaatccc agccctttgg cgctcgcccg gtggacga
//
