LOCUS       NZ_JALDPQ010000059     11368 bp    DNA     linear   CON 28-MAY-2024
DEFINITION  Streptomyces sp. TRM75563 730, whole genome shotgun sequence.
ACCESSION   NZ_JALDPQ010000059
VERSION     NZ_JALDPQ010000059.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TRM75563
  ORGANISM  Streptomyces sp. TRM75563
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 429529)
  AUTHORS   Chen,Y.
  TITLE     Streptomyces aheensis sp. nov., isolated from road
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 429529)
  AUTHORS   Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2022) College of Life Science, Tarim University,
            Hongqiao, Alar 843300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 14-MAR-2022
            Assembly Method                   :: ABySS v. V2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022748615.1-RS_2024_05_28
            Annotation Date                   :: 05/28/2024 05:18:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,476
            CDSs (total)                      :: 7,413
            Genes (coding)                    :: 7,165
            CDSs (with protein)               :: 7,165
            Genes (RNA)                       :: 63
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 249
            CDSs (without protein)            :: 248
            Pseudo Genes (ambiguous residues) :: 1 of 249
            Pseudo Genes (frameshifted)       :: 108 of 249
            Pseudo Genes (incomplete)         :: 202 of 249
            Pseudo Genes (internal stop)      :: 19 of 249
            Pseudo Genes (multiple problems)  :: 75 of 249
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:22:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 122837
            Orig. end                         :: 134205
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALDPQ010000059.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6368)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(1520..3259)
                     /locus_tag="MQC87_RS13205"
                     /old_locus_tag="MQC87_13205"
     CDS             complement(1520..3259)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955801.1"
                     /locus_tag="MQC87_RS13205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_13205"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_242739077.1"
                     /transl_table=11
                     /translation="MMLHPELLRAANTARRPLGLATALLAAVTATHLAQAVLLALVLSR
                     IAQGQTAALAPLLTAVIVVVLVRAGLGRAQRLVAVTAGATVRVGLRDTLLRRLGALGPT
                     AITGARAGAVRATLVDGVEGVDAYISRYLPQLLITCAVPPLLLVAVALVEPYAALALGP
                     ALLLALFGPRWWDRLLARRGKEHWDSYEALAADYLEALQGMPTLRTAGAVGRVRERLER
                     RSAALHRTTVAKLRVSLVDTGLTDLAVQGGTVAAVLVACSSAATDRTAATGTYLLLLLA
                     SECFRPVRDLSREWHAGYLGVSAADGIAALRTAEAAVPDRGTVAAAWKNAPEIRFEDVH
                     FTHPGSTRPALDGVSFTAAPGRTTAVVGPSGAGKSTLVSLLLRQRDPDRGRLTVAGTDT
                     AAYTLASLRRGIAVVSQETYLFHATIAENLRIARPAATDEQLRAAARTAGIDQEIARLP
                     DGYATLVGERGATLSGGQRQRLALARALLADAPVLILDEATSAVDERGQTRIVRELTAA
                     GRGRTCIVVAHRLDAVRHADHIVVLDAGRVVAAGDHTSLLAGGGVYASLVAAGRTAQEE
                     RAA"
     gene            complement(3368..4987)
                     /locus_tag="MQC87_RS13210"
                     /old_locus_tag="MQC87_13210"
     CDS             complement(3368..4987)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377866.1"
                     /locus_tag="MQC87_RS13210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_13210"
                     /product="nitroreductase"
                     /protein_id="WP_242739079.1"
                     /transl_table=11
                     /translation="MPDTPDRTAAPASGAVAAQPAAPASAARSVLPGPPAPGAGAELPD
                     VAEACGAGAAGPVTPADVSASARAPEPVSGGDVVADARPAAPGFLRQALADARSPRVPA
                     LSSYVPERPFPWNGAGLPVAGTGVTAEGSIDLDRVLRLSLAAPTRTPGRLRPVPSAGAL
                     HPVRAHLLLGPGCSLPPGRYAYDPRTHRAHPRGPAPADLPAGALVVLTVAASRTVAHYG
                     HRAWPLLLLDTGHAAAALALAASSALDVRVCLDADAALLSAAAGLPRAPDWQDAWPGTE
                     PELPLGVVRLVHRGSRSADAEGALNAWAELPQATAPAPQPGADTAPPRELAAARHLLDH
                     VARAPEQPGGTWYRAARPKPVTDDVLKARRSAPPADLNLPPGKDLLARILATAQTAHPA
                     GPAWTAAVGGPSPSLYASAPGGHGLDVRASGDARPTLAHWAARQQWVGTAGAVLLAHGC
                     PEDASPAAMRSSHLVAGYAVGAAQAHATALGLRSRPIGSWQQADLGAALGDTPRRDWIV
                     HGLALGRGGPAPASTSHPASPP"
     gene            complement(5001..6368)
                     /locus_tag="MQC87_RS13215"
                     /old_locus_tag="MQC87_13215"
     CDS             complement(5001..6368)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="MQC87_RS13215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_13215"
                     /product="YcaO-like family protein"
                     /protein_id="WP_242739490.1"
                     /sec_met_domain="YcaO (E-value: 3.8e-46, bitscore: 152.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSALPIEALVDPVTGIIRDVAPVEHPTGAPPRYTAMTADVADAR
                     RLGAWPADRVSLGTTFGDPRGAWIAAVAEAVERYCGNRLPPPGHPQEPRRATAAELAAE
                     GHRLYGPGALPAYAPWQYGRSGFPYAELTDDTPVLWTRAVEDGEPCWAPVALTHLNWRQ
                     GDLRSLSRTHHLNYAGIATGQGLDDAVERGLLEVVERDALELWWHLDGPTRGIDPASVP
                     GLTEDLAGCGLDVHIVEMPSEFAPCVAALVHDPGRGIHAAGFACRYDPAEAARKAVLEA
                     VHTWVFTQGAVDADGWVYRAVEAGMLARGLYLDHRADRRYLDDCGPEFAAVRDLGAHVQ
                     VWLDDRMAPLARRFTEPALGVVPVTEIASGSRTALDAALAAGGHRVITADLTTEDVAET
                     TLRVARVLVSGLIPNAPAAFGYFGCPRFADAAFARGWRSRPPADPEDFTLAPPPHM"
     gene            complement(6365..8041)
                     /locus_tag="MQC87_RS13220"
                     /old_locus_tag="MQC87_13220"
     CDS             complement(6365..8041)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955799.1"
                     /locus_tag="MQC87_RS13220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_13220"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_242739081.1"
                     /transl_table=11
                     /translation="MNARTVYVPTSEGIALATDVCLPDGARPRPAVVIRTPYGRDAHRA
                     ELRGWAAHGFAALAQDVRGRHGSPGEWHPYRGHEKTDGAATVAWVRAQAWSSGEVVAVG
                     ASYAAHCALVTALATADGALLDGVPDAVIAAVPALGLIETAREPGGPERLWARAGWWAA
                     HGDRRDSDPDALDRALADDPRLLEHLPIARLADRLADGLGRQLPSWPRLWAGRSRGRLV
                     AQGSAARLPLLAVGGTRDPFAEDTVALWHAWGGPSRLLLGPWGHRLTADPAAPARARVN
                     LGALYVRWARAALAGHLEPTRHGVIALGDSGRWHGMRARSAPRPPSPDSHRDRRTVTTD
                     AAARASAEAAATVRVLPAVPVPSPDTAPAPTVAWPFGSSTGLRLLHGADFSADPDRPVR
                     SDDLAVPAGGDRADRCLLLSPPLPRPLDLAGAAVARINVTADTPCADWAVRLTALDPSG
                     RADPLAFGIVRRTGPPGEAVDITVPLGTLGRRLPAGTRLRAEIAGHHFPAHARNPHTGE
                     DPVRATRLVTSHRTVNPRGSALHLPVVARRRYVEPVPEICR"
     gene            complement(8038..8988)
                     /locus_tag="MQC87_RS13225"
                     /old_locus_tag="MQC87_13225"
     CDS             complement(8038..8988)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512969.1"
                     /locus_tag="MQC87_RS13225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_13225"
                     /product="hypothetical protein"
                     /protein_id="WP_242739083.1"
                     /transl_table=11
                     /translation="MTRSRLAPGTGIVTAPGAGPVLRTSGGEFLRIDTGGVDAETLVRR
                     LVEGKASEEGAHPAELAVLVEAFEEGGHAVSSPPRAPLAGRTVHVLGDPVLTGPMARCA
                     GAEGAEVHETTPDRVAELARATTSDRSAEGRVAVVWCLDSPVPEGLWDAADRLPGQGIA
                     WLRCHREGAHVWTEPPASAPGDVTARHVRLRRLAATAAHRELAAYWAGHRTPDTGPHPT
                     EASAALIAGLLTADLIAWAEAGAARGPGGSAGVGAGAEAPAGPSGPTGLPPRRRMRRID
                     LRDLTVTEHPVLPVPDVAPLPAPAPVTARTAKARR"
     misc_feature    9028..9042
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.04"
                     /tool="antismash"
     gene            complement(9154..9288)
                     /gene="amiA"
                     /locus_tag="MQC87_RS13230"
                     /old_locus_tag="MQC87_13230"
     CDS             complement(9154..9288)
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="MQC87_RS13230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_13230"
                     /product="streptamidine family RiPP"
                     /protein_id="WP_240805756.1"
                     /transl_table=11
                     /translation="MENNKVFSPIADQGQLAHLSATHSNALVENPFDDAVEADTAGEK"
     misc_feature    9366..9379
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.45"
                     /tool="antismash"
     misc_feature    complement(9366..9381)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.88"
                     /tool="antismash"
     gene            complement(9367..10140)
                     /locus_tag="MQC87_RS13235"
                     /old_locus_tag="MQC87_13235"
     CDS             complement(9367..10140)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639452.1"
                     /locus_tag="MQC87_RS13235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_13235"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_242739492.1"
                     /transl_table=11
                     /translation="MVLRGVDLSIRAGELVALIGLNGCGKSTFLKLAAGLLTPSGGRVL
                     LEGDDVARLPRRTAARRVALLHQSAPTVPGLTVRQLVRQGRYAARGPLGMLREGDDEVT
                     SRALADVGVTAWADRPVDALSGGERQRVRLAMALAQDARVLFLDEPTTYLDLRHQLEVL
                     QAVVRLRAERRLTVVMVLHDLNHAARFADRIVALREGRVAADGPPAEVVTRQLLAEVLG
                     VDGRVGIDSEGGWPVCYPDHPLEPPQLLRNENHIH"
     misc_feature    10780..10789
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 acgagcacgc gcgggccgct gagcagcccg cgggccagcg ccacccgggc gcgctgtcct
       61 ccggacaggg tcgcgccgcg ctcgccgacg gccgtgtcca gcccgtcggg cagggcgtcg
      121 gcgatgacgt cgacgccgca gatccgggcc accgcgccga cctcgtccgc cgtggcgtcc
      181 ggagcgccca ggcggaggtt ctcggcgagg gtgccgtgga agagcggggc ctcctgcccg
      241 acgacggaca cggtggcgcg caggtcctcc tcggtgaggt cccgcaggtc gacggggtgc
      301 tcggggtccg ggggcaccag ctccacggcg ccttcggccg gatcccagta ccgcgccagg
      361 aggtgggcgc aggtcgactt gcccgccccg gacgccccga cgagggccac ggtctcgccc
      421 ggccggacgg tgaggtcgac gccgtccagg acggccgctc ccccgtagcc gaaccgcaga
      481 ccgcgcagcc gcaggcccag cggtccgggc ggtacggggc ggggcgcggc cggggcgggc
      541 gctccggcgg gggcgtgcac ggcggcccgg acgcgggccg cggcggcgcg caggccaccc
      601 gcacggccga gcgcggcggc cgattcggcg accggggcca gggcgcccag ggcgagggcc
      661 atcgcggccg gggcccaggc cccgtccagg cgtccggcgg aggccgcgtg ggcggcggcc
      721 gccacgaccg cgatgacggc ggcgacgacc agcagatcgc gggccgcgcc cgcgccggtc
      781 tcccaggact gttcggcgcg ctgggcgcgg gcgagccgac gcccggcgga ccggagccgg
      841 gcccgcctgc ggttcagcgc ccccgccatc aggagctcgc gcagcccgtc gacgctctcc
      901 acggtctcgg acgagacctc ggcgagcgcg ctccgggtcc gggccccgcg ttcggcccgc
      961 ccgcgcgctt cgaagagcgg cgaccagaca aggagcagcg cggcgggcac gacggcgagc
     1021 agcagccagg gcccgagggc cgccagcacg gcggccgaca ccgcgaagac cacgccggac
     1081 gcgaggagtt gggcgatggc gtgggcgtag aagaactcca gcgcctcgac gtccccgagc
     1141 gcggtggccg cgaggtcgcc gctgcgccgg ccggcgatcc gggcgggcgc gctgcgggcc
     1201 agcccgtcga agacccggac gcgcagttcg gcgaggaccc ggtaggcgag gtcgtgcgag
     1261 aggtccatct cgcgccaggt ggcgagggcc cggagcagga cgagcccggc caggacggcg
     1321 atggtcccgg gggcgggcgg gcggtgctcg gtgacggcgg tgcccacggt gtgcgcggcg
     1381 agcgtgacga gcgcgactag ggccgcctgg tcgacgaggg cggccaggca ggtgcgcagc
     1441 acggtggcgc ggtgcgcgcc gagcaccggg aggagcgagc ggagggcgcc ggtcggtggg
     1501 gtggaagccg gtgtcgggtt catgcggcgc gctcttcctg tgcggtgcgc ccggcggcga
     1561 cgagtgaggc gtagacgccg ccgcccgcga gcaggctggt gtggtcgccc gccgccacga
     1621 cacggcccgc gtcgagaacg acgatgtggt cggcgtggcg tacggcgtcg agccggtggg
     1681 cgacgacgat gcaggtgcgg ccgcgtccgg ccgccgtcag ttcccggacg atgcgcgtct
     1741 ggccgcgttc gtcgaccgcg ctggtggcct cgtccaggat caggacgggc gcgtcggcca
     1801 gcaacgcccg ggcgagggcg agccgttggc gctgtccgcc ggagagcgtg gcgccgcgtt
     1861 cgccgacgag ggtggcgtaa ccgtccggca gccgggcgat ctcctggtcg atcccggcgg
     1921 tgcgggcggc ggcgcgcagt tgttcgtccg tggcggccgg gcgggcgatg cgcaggttct
     1981 ccgcgatcgt ggcgtggaag aggtaggtct cctgcgagac cacggcgatg ccccggcgca
     2041 gcgaggcgag ggtgtacgcg gcggtgtccg tcccggcgac ggtgaggcgg ccccggtccg
     2101 ggtcccgttg ccgcagcagc aggctcacca gggtcgactt gccggccccg gagggaccga
     2161 cgacggctgt ggtgcgcccg ggggcagcgg tgaagctgac accgtccagg gcggggcggg
     2221 tgctgcccgg gtgggtgaag tgcacgtcct cgaaacggat ttcgggtgcg ttcttccagg
     2281 ctgcggccac ggtgccccgg tccggcacgg cggcttcggc ggtgcgcagg gcggcgatgc
     2341 cgtcggccgc cgacaccccg aggtagcccg cgtgccactc gcgggagagg tcgcggacgg
     2401 ggcggaagca ctcggaggcg aggaggagca ggaggtaggt gccggtggcg gcggtacggt
     2461 cggtggcggc cgaggagcac gccacgagga cggcggcgac cgtgccgccc tggacggcga
     2521 ggtcggtgag cccggtgtcg acgagcgaga cccggagttt ggcgacggtg gtccggtgca
     2581 gggcggccga ccgccgctcc agccgttccc gcacccggcc cacggcgccg gcggtgcgca
     2641 gggtcggcat cccctggagg gcctccaggt agtcggcggc gagggcttcg taggagtccc
     2701 agtgctcctt gccgcgccgg gcgagcagcc ggtcccacca gcgcggcccg aagagagcca
     2761 gcagcagggc ggggccgagg gcgagggccg cgtacggctc gacgagtgcg acggcgacga
     2821 gcagcagcgg cggaacggcg caggtgatga ggagttgggg cagatagcgc gagatgtacg
     2881 cgtcgacgcc ctcgacgccg tccaccagcg tggcgcgcac ggctccggcc cgcgccccgg
     2941 tgatcgcggt ggggccgagc gccccgagcc gtcgcagcag ggtgtcgcgg agcccgaccc
     3001 gtacggtggc tcccgccgtg acggcgacga ggcgctgggc gcggccgagg ccggcgcgga
     3061 ccaggacgac gacgatgacg gccgtgagca gcggggccag ggcggcggtc tgtccttgcg
     3121 cgatccggga gagcacgagg gcgagcagga cggcctgggc gaggtgggtg gcggtgaccg
     3181 ccgcgagcag tgcggtggcg aggccgagcg ggcggcgcgc ggtgttcgcg gcgcgcagga
     3241 gttcggggtg gagcatcatg ggcgttcttc ctcgccgggc ggggccgtcg ggtgacgggg
     3301 tcggggccgg gtgtgccggg ggtcgggtgt cagaggtcgg gtttcgggtt cctggacggg
     3361 ctgcggtcta cggaggtgag gcgggatgcg atgtactcgc aggtgccggg ccgcccctgc
     3421 ccagggccag accgtgcacg atccagtcgc gtcggggggt gtcgccgagc gccgcgccca
     3481 ggtcggcctg ttgccaggag ccgatggggc gggagcgcag gcccagtgcg gtggcgtggg
     3541 cctgggccgc gccgaccgcg tatccggcga cgaggtggct gctgcgcatc gcggccggtg
     3601 acgcgtcctc ggggcagccg tgggcgagga gtaccgcgcc cgcggtgccg acccactgct
     3661 ggcgtgcggc ccagtgggcg agggtggggc gcgcgtcgcc ggaggcgcgg acgtcgagac
     3721 cgtgaccgcc gggggccgat gcgtacaggg acggggaggg gccgccgacc gctgcggtcc
     3781 aggcgggtcc ggcggggtgt gctgtctgcg cggtggccag gatccgggcg agcagatcct
     3841 tgccgggcgg gagattcagg tcggcgggcg gggcgcttcg gcgcgctttc aggacgtcgt
     3901 cggtcaccgg cttcgggcga gcggcgcggt accaggtgcc gccgggctgc tcgggggccc
     3961 gtgcaacgtg gtccagcagg tgccgtgcgg cggcgagttc gcggggcggg gcggtgtcgg
     4021 cgccgggttg cggcgcaggg gctgtggcct gaggcagctc cgcccaggca ttcaacgccc
     4081 cttcggcgtc cgctgaccgg ctgccccggt gcaccaaccg gaccactccc agcggcagtt
     4141 ccggctccgt gccgggccag gcgtcctgcc agtccggggc acgaggcagg ccggcggcgg
     4201 cggacagcag agcggcgtcc gcgtcgaggc agacccgcac gtcgagggcc gaggacgcgg
     4261 ccagcgccag cgcggcggcg gcatggcccg tgtccaggag cagcagcggc caggcccggt
     4321 gaccgtagtg ggcgacggta cgggacgcgg ccacggtgag gacgacgagc gcgcccgcgg
     4381 gtaggtcggc gggggccggg ccgcgcgggt gggcgcggtg cgtgcgcggg tcgtaggcgt
     4441 accgcccggg cggcagcgag caacccggcc cgagcaacag gtgggcgcgc accgggtgga
     4501 gggcgcccgc cgagggaacg ggccgcagcc tgccgggggt tcgggtgggc gcggcaaggg
     4561 acagccgcag cacgcggtcg aggtcgatgg agccctcggc cgtgactccg gtcccggcca
     4621 cgggcagccc agcgccgttc cacgggaacg gacgctccgg aacgtacgag gagagggcgg
     4681 ggacgcgcgg cgagcgggcg tccgcaagcg cctggcgcag gaagcccggt gcggcgggcc
     4741 gggcgtcggc aacgacgtcg ccaccggata ccggctccgg ggctcgggcg gaggcagaga
     4801 cgtcggccgg cgttacgggc cccgccgccc ctgccccgca cgcctccgcc acgtccggca
     4861 gctcggcgcc cgccccggga gcaggcgggc caggcagcac ggaacgcgcc gccgaggcag
     4921 gtgcggcggg ctgcgcggcg actgccccgg aggcgggcgc ggcagttcgg tccggtgtgt
     4981 cgggcatggg gcacactcct tcacatgtgc ggtggcgggg cgagggtgaa gtcctcgggg
     5041 tcggccgggg gccgggatcg ccacccccgg gcgaacgccg cgtccgcgaa gcgcgggcag
     5101 ccgaagtagc cgaaggccgc cggggcgttg gggatcaggc cggagaccag gacgcgggcg
     5161 acgcgcagcg tggtctcggc gacgtcctcc gtggtgaggt ccgcggtgat cacccggtgc
     5221 cctccggcgg cgagcgcggc gtccagcgcc gtacggctgc cggaggcgat ctcggtgacg
     5281 gggacgacgc cgagcgcggg ttcggtgaac cggcgggcga gcggggccat ccggtcgtcc
     5341 agccagacct ggacatgggc gccgaggtcc cggacggcgg cgaactcggg cccgcagtcg
     5401 tcgagatagc gccggtcggc gcggtgatcg aggtagaggc cgcgggccag catgccggct
     5461 tccaccgccc ggtacaccca gccgtcggcg tccaccgcgc cctgcgtgaa cacccacgtg
     5521 tgcacggcct ccaggacggc cttgcgggcc gcctccgccg ggtcgtaccg gcaggcgaac
     5581 ccggccgcgt ggatgccgcg ccctgggtcg tgcacgagag ccgccacaca cggggcgaac
     5641 tccgagggca tctccacgat gtgcacgtcc agaccgcagc cggccaggtc ctcggtgagt
     5701 ccgggaacgc tcgccgggtc gatgccccgg gtgggtccgt ccaggtgcca ccacagctcc
     5761 agcgcgtccc gttcgacgac ttcgaggagt ccgcgctcga cggcgtcgtc caggccctgg
     5821 ccggtggcga taccggcgta gttcaggtgg tgggtacggg acagcgaacg caggtcgccc
     5881 tgacgccagt tgaggtgcgt cagcgccacg ggtgcccagc acggctcccc gtcctcgaca
     5941 gcccgggtcc acagcaccgg tgtgtcgtcg gtgagttcgg cgtacgggaa tcccgaccgg
     6001 ccgtactgcc agggtgcgta cgccggcaga gcgccgggcc cgtagaggcg gtggccctcg
     6061 gcggccagtt cggcggcggt ggcccgccgg ggttcctgcg ggtggcccgg tggcgggagg
     6121 cggttgccgc agtagcgctc gacggcctcg gccaccgctg cgatccacgc gccccggggg
     6181 tcgccgaacg tcgtgccgag cgagacccgg tcggcgggcc aggcgcccag acggcgggcg
     6241 tcggcgacgt ccgcggtcat cgcggtgtag cggggcggcg ctcccgtggg gtgctcgacg
     6301 ggtgcgacgt cccggatgat cccggtgacg ggatcgacga gggcttcgat gggcagggcg
     6361 ctggtcaacg gcatatctcc ggtacgggct cgacgtagcg gcgtcgggcg acgacgggca
     6421 ggtggagggc gctgccccgg gggttcacgg tgcggtggga agtgacgagc cgggtggccc
     6481 tgaccgggtc ctcgccggtg tgcgggttac gggcgtgggc ggggaaatgg tgtccggcga
     6541 tctcggcccg caaccgggtt ccggcgggca gccgacggcc cagcgtgccg agcggcacgg
     6601 tgatatccac ggcttcgccg ggcgggccgg tacgccggac gatgccgaag gcgagcggat
     6661 ccgcgcggcc ggacgggtcg agcgcggtga gacgtacggc ccagtcggca cagggggtgt
     6721 cggccgtgac gttgatccgg gcgacggcgg ctcccgccag gtcgagcggg cgcggcagcg
     6781 gcggcgagag aagcagacag cggtcggcgc ggtcaccgcc ggccgggacg gcgaggtcgt
     6841 cggagcgcac ggggcggtcc gggtcggcgc tgaaatcggc tccgtggagc agccgtaggc
     6901 cggtggacga gccgaagggc caggcgacgg tgggggccgg ggcggtgtcc ggggacggga
     6961 caggtacggc gggcagaacg cgtacggtgg ctgcggcttc ggccgaggcg cgggccgcgg
     7021 catcggtggt gaccgtgcgg cggtcacggt ggctgtccgg cgacggaggc cggggggcgc
     7081 tccgcgcccg catgccgtgc cagcggccgc tgtcgccgag ggcgatgacc ccgtgccgcg
     7141 tcggctccag gtggccggcg agcgcggcgc gggcccaccg tacgtacagc gcaccgaggt
     7201 tgacgcgggc gcgggccggg gcggccgggt cggcggtgag gcggtgaccc cagggaccga
     7261 gcagcagccg ggacgggccg ccccaggcgt gccacagggc cacggtgtcc tcggcgaagg
     7321 ggtcacgggt gccgccgacg gccagcagcg gaagacgggc ggcggaaccc tgtgcgacga
     7381 gccggccccg gctccggccg gcccagagcc gtggccagga gggcagttgg cgtcccagtc
     7441 catcggccag ccgatccgcc agtcgggcga tcgggaggtg ttcgagcagc cgggggtcgt
     7501 ccgccagggc gcggtccagc gcgtccgggt cggagtcgcg acggtcgccg tgggccgccc
     7561 accagccggc ccgggcccac agccgctccg ggcccccggg ctcgcgcgcc gtctcgatga
     7621 gcccgagcgc ggggacggcg gcgatgacgg catcggggac tccgtcgaga agggctccgt
     7681 cggccgtggc caaggcggtg acgagtgcgc agtgcgccgc gtaggaagcg cccacggcga
     7741 ccacctcacc gctgctccac gcctgcgcgc gcacccacgc gacggtggcc gcgccgtcgg
     7801 tcttctcgtg gccccggtac gggtgccact cccccggtga gccgtggcgg ccgcgtacgt
     7861 cctgggccag ggcggcgaaa ccgtgggccg cccagccgcg cagctcggca cggtgggcgt
     7921 cgcgcccgta aggggttctg atcacgacgg cgggccgggg gcgagccccg tccggaaggc
     7981 atacgtcggt ggcgagcgcg atgccctcgg acgtggggac gtacacggta cgggcgttca
     8041 ccggcgcgcc ttcgcggtgc gggccgtcac cggtgcgggg gcgggcagag gtgcgacgtc
     8101 cgggacggga aggacggggt gctcggtgac ggtgagatcc cgcaggtcga tccggcgcat
     8161 ccggcggcgg ggcgggagac cggtgggccc gctcggcccg gccggggctt cggctccagc
     8221 accgacaccg gcactgccac caggccctct tgcggcaccg gcttcggccc aggcgatcag
     8281 atcggcggtg aggagcccgg cgatcagggc ggcggaggcc tcggtcgggt gcggtccggt
     8341 gtcgggagtg cggtgtccgg cccagtacgc ggcgagctcg cgatgggcgg cggtggccgc
     8401 gagtctgcgg aggcggacgt gccgggcggt gacgtctccc ggggccgagg caggcggctc
     8461 ggtccagaca tgagccccct cgcggtggca ccgcagccag gcgatgcctt gccctggcaa
     8521 ccggtccgca gcgtcccaaa gcccctcggg cacgggcgag tccaggcacc acaccacggc
     8581 gacgcgcccc tcggcgctcc ggtccgaggt cgtcgccctg gccagttccg ccacgcggtc
     8641 cggggtggtc tcgtggacct cggccccttc cgccccggcg cagcgcgcca tcggaccggt
     8701 gagtacgggg tcacccagga cgtggacggt gcgaccggcg agcggggccc ggggcggact
     8761 cgacaccgcg tgcccgccct cctcgaacgc ttcgacgagc acggcgagtt cagcggggtg
     8821 cgcaccctcc tccgacgcct tcccctccac cagccggcgc accagggtct cggcgtcgac
     8881 accgccggtg tcgatgcgca ggaactctcc tccggaggtc cggagcacgg ggccagctcc
     8941 gggagcggtg acgatcccgg tgccgggagc gagtcgactg cgggtcacgg aatcctccgg
     9001 tgcggcggga cgggatacgg aatgcgggga cgggatgttc cggggaggga acgggggcag
     9061 cgggggtgaa cgggcgggcc cgcccgggga gtcaccgggt gggcccgccc cccgcgctac
     9121 gcggggaaac ctgccgtcag cggcaggctt cgctcacttc tcgcccgcgg tgtcggcctc
     9181 gacggcgtcg tcgaaggggt tctcgacgag ggcgttcgag tgggtggcgg acaggtgggc
     9241 gagctggccc tggtcggcga tcgggctgaa caccttgttg ttctccatga gttggagtct
     9301 ccattcggtc ggatcggatg ggtgtgtcac ggcagtgatg cgttcgtgcg tgccgcagca
     9361 cagacactaa tgaatatgat tttcattccg caatagctgg ggcggttcga gagggtgatc
     9421 tgggtaacag acgggccagc cgccctcgct gtcgatcccc acccggccgt ccacgcccag
     9481 gacttcggcc agcagctgcc gggtgaccac ctcggccgga ggcccgtcgg cggcgacgcg
     9541 gccctcgcgc agcgcgacga tccggtcggc gaaccgggcg gcgtggttca ggtcgtgcag
     9601 caccatcacc accgtcaacc ggcgctccgc gcgcaaccgt acgaccgcct ggagcacctc
     9661 cagctggtgc cgcagatcga gatacgtggt cggctcgtcg aggaagagca cgcgggcatc
     9721 ctgggccagc gccatggcca gccgcacccg ttggcgttcg cctccggaca gtgcgtccac
     9781 cggccggtcg gcccaggcgg tgacgccgac gtccgcgaga gcccgggacg tcacctcgtc
     9841 gtcgccctcc cgcagcatcc ccagcggccc ccgggccgca tagcgccctt gtcgcaccaa
     9901 ctgacgtacg gtcagacccg gtacggtcgg cgccgattga tggagcaggg cgacgcgtcg
     9961 ggccgcggtg cggcggggca gccgggccac gtcgtcgcct tcgagcagga cgcggccgcc
    10021 gctcggggtg aggagtccag cggccagttt gaggaaggtg ctcttgccgc atccgttcag
    10081 cccgatcagg gcgaccagtt cgccggcacg gatgctcagg tccaccccgc gcagcaccat
    10141 gcgtcccggg tagccgaagg ccagcccttc cgcccgcacg acatccgggc cgggcgccgc
    10201 gcaggactcc gcgccctggc cgggctcctt cgccggactc gtgtccactc gttcggtcag
    10261 gccttccggc atgccggcct cctcatcgct gtacccctgt tccgtccacg tccacgtcca
    10321 cgtccatgac gacctgccgt gtccactcct cgctgcccgc cgtcatcgct cgtccgccct
    10381 tcgccgtgcc acgaccatca gcagccccgc ccccacaaag gtggtcaggg cgccgaccgg
    10441 aagggtcagc cggtccgctt cgaacgccgt tgccagcagc cgggacagca gttgggcggc
    10501 ggcgtccgcc ccgcacacca ccgccgcacc gaacagcgcg gcgcccggga gcgtgatgcg
    10561 caggtccgcg ccgaacaccg ccagcgccag atgcggcacc agcagcccca cgaagccgag
    10621 cgcgcccacc gccgagaccg cgccggctgt cagcgccacc gcgcacacga gcgccgcgcc
    10681 ccggccccga ccggtggcca gacccgccgc cgcggcctgt tcgtcgccgc agcgcagcag
    10741 ggtcagcggt ccggcgagca gccagccggc cgcgccccag aaggcggccc acggccagag
    10801 cagattccag tgctgccaca cccggccctc ggtggagccg atcaaccact gcacgacgct
    10861 gccgagttca ccgggagcca ccaggagaac gacggcggtg agtccggcga gcaccgcgga
    10921 caccaggacc ccgtagacag cggtctgctc cgggtcgccc cggtcccgcc cggcgagcag
    10981 ccacagcagc cccgctccgg cgaagccgcc gatgcaggcc gcaacgacca cggccgtggg
    11041 ggactcccag cccgcgaggc cgaggccggt cgcggccacc gcgccgagca ccgcaccggg
    11101 ggtgacgcca gtgacctcgg gtccggccag cgggttgcgc agggccgact ggagcacgag
    11161 cccggccact ccgaggcagg ccccggcgac cagcgccacc agcagccgtg gcaaacgcag
    11221 ttggagcacg atgtgctcag cggtggggtc gtcgccggcc ccgagcagta cggcccgtac
    11281 gccttcgggg gtgacgcccc ggccggcgaa cagatccgcg caggcgacca ccgcgacgag
    11341 taccaccagg ccgcccatcc ggataccc
//
