LOCUS       NZ_JALDPQ010000058     15431 bp    DNA     linear   CON 28-MAY-2024
DEFINITION  Streptomyces sp. TRM75563 729, whole genome shotgun sequence.
ACCESSION   NZ_JALDPQ010000058
VERSION     NZ_JALDPQ010000058.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TRM75563
  ORGANISM  Streptomyces sp. TRM75563
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 51526)
  AUTHORS   Chen,Y.
  TITLE     Streptomyces aheensis sp. nov., isolated from road
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 51526)
  AUTHORS   Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2022) College of Life Science, Tarim University,
            Hongqiao, Alar 843300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 14-MAR-2022
            Assembly Method                   :: ABySS v. V2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022748615.1-RS_2024_05_28
            Annotation Date                   :: 05/28/2024 05:18:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,476
            CDSs (total)                      :: 7,413
            Genes (coding)                    :: 7,165
            CDSs (with protein)               :: 7,165
            Genes (RNA)                       :: 63
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 249
            CDSs (without protein)            :: 248
            Pseudo Genes (ambiguous residues) :: 1 of 249
            Pseudo Genes (frameshifted)       :: 108 of 249
            Pseudo Genes (incomplete)         :: 202 of 249
            Pseudo Genes (internal stop)      :: 19 of 249
            Pseudo Genes (multiple problems)  :: 75 of 249
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:22:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 32951
            Orig. end                         :: 48382
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALDPQ010000058.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..15431
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="ectoine"
                     /product="butyrolactone"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..15431
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="ectoine_synt"
                     /detection_rules="AfsA"
                     /kind="neighbouring"
                     /product="ectoine"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..10375
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10375
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:5375](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5375
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    378..391
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     gene            complement(503..1096)
                     /locus_tag="MQC87_RS12480"
                     /old_locus_tag="MQC87_12480"
     CDS             complement(503..1096)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961774.1"
                     /locus_tag="MQC87_RS12480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12480"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_218525388.1"
                     /transl_table=11
                     /translation="MQERAARTRQAVLEAAADEIAERGYEGASLQRVVWRAATSMGALT
                     FHFRTKTALAEEVRGVGRARFAHRMEELAAAADPLRELRTLIGAMARLAHQDRFVRAAR
                     RLEADRPVGVPPLAEVWLPVLRGLLDRAHGADRLRPGVSPEDAVALLAHLAEGAMAAHD
                     ATRDPAWDSVWDSVWDVVLHGLAADPAGRRAGRA"
     gene            1208..2326
                     /locus_tag="MQC87_RS12485"
                     /old_locus_tag="MQC87_12485"
     CDS             1208..2326
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452971.1"
                     /locus_tag="MQC87_RS12485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12485"
                     /product="transposase"
                     /protein_id="WP_242738883.1"
                     /transl_table=11
                     /translation="MTTTYETPGMATDRPPGDLSRLLFGHLHRSDQQRWGHVYLQGLLR
                     THGKKTVRRMAAVVTGSEAASASLHQFVNASPWEWAPARGELARWAARSLPVRAWTLAP
                     AVLPKRGNCSAGVHQRFLPEAGRTVNCQLGLGLFLDAGRAHVPVDWRLFLPPRFTRDEA
                     VRDRAKIPPTTRAQPLWAHALCLVQEMTSWSNGRSAPVVADLTSLCDVAPLAQRLHGDG
                     HTFVLAVPGQTAVAGPELAPGDRESARGLLLRRGVRHPAGAGRQVVSCDAPVHGLRPDG
                     ERVSGAGRLLAEWDTAAGRPGRIWLTNITDRHPAELLELARSPGGAQEATRRMGEDFGL
                     LDFEGRSFPGWHRHMTLVSAAYACSTLEGRGR"
     misc_feature    complement(2360..2373)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.38"
                     /tool="antismash"
     misc_feature    2367..2382
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.99"
                     /tool="antismash"
     misc_feature    2426..2439
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.74"
                     /tool="antismash"
     gene            2477..2920
                     /locus_tag="MQC87_RS12490"
                     /old_locus_tag="MQC87_12490"
     CDS             2477..2920
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489542.1"
                     /locus_tag="MQC87_RS12490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12490"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_030075956.1"
                     /transl_table=11
                     /translation="MTIQQQPRAASDQTMWEAVLGLHAFVERQLAHALQRRYGVGLSEY
                     RALEALTQAEKGESRMQELADHIGLGQSSVTRLVGRLESAGYAYKDNCADDKRGVFAVI
                     TEEGRKRYQDARATYADVLSSALNTASADDQLARAVQALRSAA"
     misc_feature    complement(3044..3057)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.22"
                     /tool="antismash"
     gene            3118..4602
                     /locus_tag="MQC87_RS12495"
                     /old_locus_tag="MQC87_12495"
     CDS             3118..4602
                     /NRPS_PKS="Domain: AMP-binding (9-395). E-value: 2.5e-57.
                     Score: 186.2. Matches aSDomain:
                     nrpspksdomains_MQC87_RS12495_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060210.1"
                     /locus_tag="MQC87_RS12495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12495"
                     /product="AMP-binding protein"
                     /protein_id="WP_242738885.1"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-59, bitscore:
                     193.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSPRLLQAFSRHVQEQPDSTALVNAGQQVTYADLERLTRRATAD
                     LEGAGFGFVRALCVPAHKSPETIALLLAAWRQGINTLVPSPALGAAALSTLIAQAHGPL
                     SATAVPGGGVTLSREEADPALADGFGIPDPAESLLTLTTSGSTGVPKLVPVRTEAFDRF
                     ADWAATAFGIDGGTTALSFSPLNFDLALLDVWTVLEAGGTVVLADAGASGDAGYLRDLA
                     QRNEVTLVQGVPLLHRLLAADGARYPAVRTVVFTGEAVSEQGLRDTFAACPAARFHNVF
                     GCTETNDSFIHDIDPDAYTHPLPIGVPIDGTDAVLLIEGPDGTEVLRGPGTGELLVHTP
                     FQTCGYLEQARNAHAFMPDPRGGGAMFYRTGDLVHRDADGRHFLQGRTDFQVKVRGVRT
                     NTLEVETVLGAHPDVVEAAVVALPCPEAGTRLHAEVVRRDGTSLSTLGLRAYAAKHLPR
                     HAVPSSVGLARTPLPKTPTGKPDRNSIKNTQLNGAS"
     aSDomain        3145..4302
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MQC87_RS12495_AMP-binding.1"
                     /evalue="2.50E-57"
                     /label="MQC87_RS12495_AMP-binding.1"
                     /locus_tag="MQC87_RS12495"
                     /protein_end="395"
                     /protein_start="9"
                     /score="186.2"
                     /specificity="substrate consensus: Ala"
                     /tool="antismash"
                     /translation="FSRHVQEQPDSTALVNAGQQVTYADLERLTRRATADLEGAGFGFV
                     RALCVPAHKSPETIALLLAAWRQGINTLVPSPALGAAALSTLIAQAHGPLSATAVPGGG
                     VTLSREEADPALADGFGIPDPAESLLTLTTSGSTGVPKLVPVRTEAFDRFADWAATAFG
                     IDGGTTALSFSPLNFDLALLDVWTVLEAGGTVVLADAGASGDAGYLRDLAQRNEVTLVQ
                     GVPLLHRLLAADGARYPAVRTVVFTGEAVSEQGLRDTFAACPAARFHNVFGCTETNDSF
                     IHDIDPDAYTHPLPIGVPIDGTDAVLLIEGPDGTEVLRGPGTGELLVHTPFQTCGYLEQ
                     ARNAHAFMPDPRGGGAMFYRTGDLVHRDADGRHFLQGRTDFQVKVR"
     CDS_motif       3538..3582
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MQC87_RS12495_0001"
                     /evalue="4.80E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="MQC87_RS12495"
                     /protein_end="155"
                     /protein_start="140"
                     /score="13.1"
                     /tool="antismash"
                     /translation="LTTSGSTGVPKLVPV"
     CDS_motif       4273..4332
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MQC87_RS12495_0002"
                     /evalue="6.00E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="MQC87_RS12495"
                     /protein_end="405"
                     /protein_start="385"
                     /score="18.8"
                     /tool="antismash"
                     /translation="GRTDFQVKVRGVRTNTLEVE"
     cand_cluster    4508..15431
                     /candidate_cluster_number="3"
                     /contig_edge="True"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    4508..15431
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[9507:10431](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(9508..10431)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
     gene            4602..4907
                     /locus_tag="MQC87_RS12500"
                     /old_locus_tag="MQC87_12500"
     CDS             4602..4907
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763164.1"
                     /locus_tag="MQC87_RS12500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12500"
                     /product="acyl carrier protein"
                     /protein_id="WP_242738887.1"
                     /sec_met_domain="PP-binding (E-value: 4.4e-08, bitscore:
                     25.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTASTTSTTADTATTGTGGDDPIRDYIVQEFLGGEDAADLTDDF
                     DLIESTVVNSLGLVRLISWISETYGIPVDDIPLEPAAYRTLADIRDFVGKAAPAAV"
     gene            5001..5375
                     /locus_tag="MQC87_RS12505"
                     /old_locus_tag="MQC87_12505"
     CDS             5001..5375
                     /GO_function="GO:0033990 - ectoine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452967.1"
                     /locus_tag="MQC87_RS12505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12505"
                     /product="ectoine synthase"
                     /protein_id="WP_030633930.1"
                     /sec_met_domain="ectoine_synt (E-value: 3.1e-26, bitscore:
                     84.1, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSLSDVPAVEWGSGTSHRLLTEADGMGFTVCETLVRQGTSSA
                     LQYLGHLEACYCIGGSGEVVTTDGAHHKITTGTIYALDKNDAHHLIASDDEDLLLVSVF
                     SPALRGDEKHALSEDGFSRY"
     gene            5472..6602
                     /locus_tag="MQC87_RS12510"
                     /old_locus_tag="MQC87_12510"
     CDS             5472..6602
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489546.1"
                     /locus_tag="MQC87_RS12510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12510"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_242738889.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.9e-20, bitscore:
                     64.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.5e-28, bitscore:
                     90.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 5.1e-34, bitscore:
                     109.5, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAENATDTYGVTAPYGDELNDDVARWDRAAEFPHEKWKPLQRSG
                     LFTLPFAPEYGGAGRTLTETMAALEGLGHTSRDAGLNFSASTQIVSVGIPLQAFGSEEL
                     RGRYLPRVTSGEAITAHAITEPSHGSDVMNIRTTAVREGDEYVLNGGKMFITNAPVADL
                     FLLYVRTGKPGAFGLSTFLAERGTPGLRIGRPLETMGLRTSPISEVTLEDVRLPVGNRL
                     GSEGAGFLIMDYVMKREVLFSFAVNLGEMTHRLKRVVEHATTRQQFGSAIGKNQAVAHK
                     ITDMKIAVETARKWLYETGHKVEQGKDASLDVAATKIVVSEANQLTAQHAIQIFGARGY
                     LTDTGIERELRNATSGSIYSGTNEIQRNCIAALMGL"
     gene            6617..7369
                     /locus_tag="MQC87_RS12515"
                     /old_locus_tag="MQC87_12515"
     CDS             6617..7369
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452965.1"
                     /locus_tag="MQC87_RS12515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12515"
                     /product="transglutaminase family protein"
                     /protein_id="WP_242738891.1"
                     /transl_table=11
                     /translation="MTDTLAPTTSARPTAEDRAASEPPTAEDRARLTAATDFLDHEHER
                     VRAFVDKALNGIDRDAADPVDLAVALYYAVRDGIHYEVYGADLSPQGLKASAVISGGKG
                     FCLHKSVVYAACCRAVGIPARLHYSDVRNHLASDRLRSYIGGDVFFHGLATVYLEGRWV
                     KVTPVFNKLLCRLYGMTPLEFDGHSDSLYHPFDAQGRQSMEFLTDHGDFDDVPYPFVME
                     NMRRKHPKFLDEDGTGTVGGGSLADEAA"
     gene            7471..8286
                     /locus_tag="MQC87_RS12520"
                     /old_locus_tag="MQC87_12520"
     CDS             7471..8286
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452964.1"
                     /locus_tag="MQC87_RS12520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12520"
                     /product="maleate cis-trans isomerase"
                     /protein_id="WP_242738893.1"
                     /transl_table=11
                     /translation="MTQFQAREDGWAVAARVGVVVPHADVGPESELQAMAPRDVYIHGS
                     RVHFGAMRPGGEMDPKIPHDPVRAFIDPPFIDDAVELLAAAPLDSIALGFTSSAYVLGA
                     DGEQKLFERLADRTRGIPLTGTTHAAAAGFAALGAERIALVNPPWFDDELSALGASYFG
                     ERGFDVVHHAPCGLPSNQKLITPEALVQWIESTVAPQRPQAVLVAGNGIRAVGTIAGLE
                     ERLGFPVLTANQVLFWHALHLAGGTGAAARISEYGALFGVRPEGVGAAR"
     gene            8283..8525
                     /locus_tag="MQC87_RS12525"
                     /old_locus_tag="MQC87_12525"
     CDS             8283..8525
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489549.1"
                     /locus_tag="MQC87_RS12525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12525"
                     /product="DUF6253 family protein"
                     /protein_id="WP_030633922.1"
                     /transl_table=11
                     /translation="MSMLPAYGYQAAVQETCDTPEYHLPLVCWHDDGTGVRGLVLYRGG
                     LRPAEQVPGFRRYLASEDLEQHAMTGPWPLLAATA"
     gene            8581..9351
                     /locus_tag="MQC87_RS12530"
                     /old_locus_tag="MQC87_12530"
     CDS             8581..9351
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (132-191). E-value: 7.6e-08. Score:
                     24.2. Matches aSDomain:
                     nrpspksdomains_MQC87_RS12530_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763171.1"
                     /locus_tag="MQC87_RS12530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12530"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_242738895.1"
                     /transl_table=11
                     /translation="MTHDLTWSDAPPGEVLDPVGIWIVRAPAGQRLAADGAPPDWLDEK
                     ERRRLAGIPQPAGREAYAFAHWALRSVLGSSLGCSPRSVGFLRQPCPGCGGAHGRPAIR
                     DPDQGDEPLEFSMSHSGDHVAIAVAEATIGIDIESWPTPESVAGYLPFLHPKEQEWLAG
                     RPDDELVRDFARLWTRKEAMAKATGQGMAAVMNRLDLTGQPLGWRVRQLLAPPGYEASF
                     AVPASVHVAVTVHEELPEPMPGPGPVRKPEPVRA"
     aSDomain        8977..9153
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MQC87_RS12530_ACPS.1"
                     /evalue="7.60E-08"
                     /label="MQC87_RS12530_ACPS.1"
                     /locus_tag="MQC87_RS12530"
                     /protein_end="191"
                     /protein_start="132"
                     /score="24.2"
                     /tool="antismash"
                     /translation="IGIDIESWPTPESVAGYLPFLHPKEQEWLAGRPDDELVRDFARLW
                     TRKEAMAKATGQGM"
     gene            complement(9508..10431)
                     /locus_tag="MQC87_RS12535"
                     /old_locus_tag="MQC87_12535"
     CDS             complement(9508..10431)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452960.1"
                     /locus_tag="MQC87_RS12535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12535"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_242738897.1"
                     /sec_met_domain="AfsA (E-value: 1.2e-23, bitscore: 74.8,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVSVLSREFPPVQQSQVHQWQVHKLRREEVLLTAWAERSPGHYA
                     LTGRWPRGHAFYRPTRGAYDPMLFAESVRQTVPLLSHAVHDVPRAYKQAWEHFSFSVDP
                     LASLVTTVDEEVRLVVTCSDVVRRGSRFAGMTMDIDVHLGDRLMGSAHTRFNNQPAAVY
                     RRLRGSYADADAALASCLPAGPPVDPHRVDRESPDDVVLSPVASGRPGRWMLRVDPTHP
                     VLFDHAVDHAPGMLLLEAARQAAHAVGGGSSTVFGMRTHFARYVELDAPAVVVAGEPVP
                     DGTGRRRVDVSVEQHGVRVFTSEVTI"
     misc_feature    complement(10506..10515)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.04"
                     /tool="antismash"
     misc_feature    complement(10507..10520)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.55"
                     /tool="antismash"
     misc_feature    complement(10508..10523)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.77"
                     /tool="antismash"
     gene            10674..11381
                     /locus_tag="MQC87_RS12540"
                     /old_locus_tag="MQC87_12540"
     CDS             10674..11381
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489552.1"
                     /locus_tag="MQC87_RS12540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12540"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_242738899.1"
                     /transl_table=11
                     /translation="MAQLKQERAEQTRRVLLHAAAEVFDEFGYAGASITRILKRAGVTA
                     GALYFHFGSKEDLARAVMNSQPETLVPLIAAGGLQRLIDLTLVWSWQLQRDPLLRAGVR
                     LTNEQAAMGGSLNADPYDNFRGIMTGCLHEAREEGELQPGIDPVVVAEFVVAACTGMQM
                     YSNVISGRKDLPERTQQMWNLLLPGIAVPSVIIRADATPARGISLMPGTPERTGTPEQA
                     DAPAPTEAPEQPG"
     gene            11543..12262
                     /locus_tag="MQC87_RS12545"
                     /old_locus_tag="MQC87_12545"
     CDS             11543..12262
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763173.1"
                     /locus_tag="MQC87_RS12545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12545"
                     /product="HAD family phosphatase"
                     /protein_id="WP_242738901.1"
                     /transl_table=11
                     /translation="MLSLRLAALNIDGVLLNDTFSPVIHHFIVSRGGTYSAELERSIFS
                     QPQHIAGRLLSAAVGGDMTGEEALAAYFEDRAAHLDRHPVTVTPGTRDLLLRLRAAGLL
                     TVCYGGLGKDHFDRHLGHCAELFDGPGYVCTNDIRPGVREITEDVFGLRPAQALFVDDV
                     ARVADAARELGTAFVGRPSDFVHSHQRALMRESGVRHLIGGLDELDDDLVRRIDRETVT
                     GSLWSTPLATAGQGTYA"
     gene            12262..13029
                     /locus_tag="MQC87_RS12550"
                     /old_locus_tag="MQC87_12550"
     CDS             12262..13029
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (10-180). E-value: 4.1e-14.
                     Score: 44.8. Matches aSDomain:
                     nrpspksdomains_MQC87_RS12550_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019763174.1"
                     /locus_tag="MQC87_RS12550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12550"
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_242738914.1"
                     /sec_met_domain="adh_short (E-value: 4.7e-39, bitscore:
                     126.0, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 2.2e-33, bitscore:
                     108.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGGPLLPGKVALITGASSGIGAAAARHFADEGAAVVLVARRACL
                     VEEVAERIRKDGGRAVAVPGDVTVRADMEHAVATAVDRFGRLDCAFNNAGYASAGTVLH
                     ELPDDVFDRTMDVNLRGVWNCLRAQIPAMLPAGAGSVVNTSSVAGVRATAASAPYVAAK
                     HAVIGLTRAAAAEYGEHGIRVNALVVGSTDTEMMDGVLAAGPTVRAGFGSKAIQQRLAD
                     PTEIARAAAWLCSDASSFTTGSALAVDGGRTAK"
     aSDomain        12292..12801
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MQC87_RS12550_PKS_KR.1"
                     /evalue="4.10E-14"
                     /label="MQC87_RS12550_PKS_KR.1"
                     /locus_tag="MQC87_RS12550"
                     /protein_end="180"
                     /protein_start="10"
                     /score="44.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALITGASSGIGAAAARHFADEGAAVVLVARRACLVEEVAERIRK
                     DGGRAVAVPGDVTVRADMEHAVATAVDRFGRLDCAFNNAGYASAGTVLHELPDDVFDRT
                     MDVNLRGVWNCLRAQIPAMLPAGAGSVVNTSSVAGVRATAASAPYVAAKHAVIGLTRAA
                     AAEYGEH"
     CDS_motif       12298..12387
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MQC87_RS12550_0001"
                     /evalue="5.80E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="MQC87_RS12550"
                     /protein_end="42"
                     /protein_start="12"
                     /score="22.2"
                     /tool="antismash"
                     /translation="LITGASSGIGAAAARHFADEGAAVVLVARR"
     gene            complement(13143..13559)
                     /locus_tag="MQC87_RS12555"
                     /old_locus_tag="MQC87_12555"
     CDS             complement(13143..13559)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452955.1"
                     /locus_tag="MQC87_RS12555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12555"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_137235707.1"
                     /transl_table=11
                     /translation="MSNAAKSSTNAWLSLLLAGVFEIGYALAVGGSEGFTVLTWSLVAV
                     VFFLLTLYALSLALRTIDVSIGYAVWAGIGAVGAAVLGPLFFDETLTLAKGAWLAVIIV
                     GVIWLKLADRTKPEAAAPAQESGQLAGEPSAVRV"
     gene            complement(13650..13970)
                     /locus_tag="MQC87_RS12560"
                     /old_locus_tag="MQC87_12560"
     CDS             complement(13650..13970)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967532.1"
                     /locus_tag="MQC87_RS12560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12560"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_242738903.1"
                     /transl_table=11
                     /translation="MHWLYLAIAVAFEITVAIAAGKAEGFKNRKWTTITLLSGAAATFF
                     LSKALLTFDVGVGYALWTSVAGVGITILGALFFGQRLNVNKAIGILLVIGGVVGLQLSG
                     SA"
     gene            complement(14039..14518)
                     /locus_tag="MQC87_RS12565"
                     /old_locus_tag="MQC87_12565"
     CDS             complement(14039..14518)
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0019239 - deaminase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452953.1"
                     /locus_tag="MQC87_RS12565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_12565"
                     /product="nucleoside deaminase"
                     /protein_id="WP_242738905.1"
                     /transl_table=11
                     /translation="MATHESELMGYAHEAIRLSGEHVAQGGIPFSGVVVAGGRILGTGF
                     NRVREDNDPTAHAEVVALREATTKHGIRSVAGATLIASGEPCALCYLAARYAGIGHIVH
                     AADRRTAARYGFDYTSTYTLFAEDPADWPIKVTALQLPEAEQPFQDFLTLSRAAR"
     misc_feature    complement(14548..14559)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    complement(14557..14570)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.22"
                     /tool="antismash"
     misc_feature    complement(14624..14637)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.36"
                     /tool="antismash"
     misc_feature    14627..14640
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.53"
                     /tool="antismash"
     misc_feature    14627..14645
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.24"
                     /tool="antismash"
     misc_feature    complement(14628..14641)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.3"
                     /tool="antismash"
     misc_feature    14634..14647
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.92"
                     /tool="antismash"
     misc_feature    14841..14856
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.92"
                     /tool="antismash"
ORIGIN
        1 atcgtcccct cgctgggggc gtacgcgtcg gcccgcggtc tcgcccggct ccagggcgtg
       61 ctggccgcgg acgccgtacg ggccccgggc gaggagccgt tgctgttgtc gcgccgcacg
      121 ctcgaccagg cgcgcagctt ctgggccgag ggcctggatc cgctgctcgg cggggtcagc
      181 gcgtacggcg agggcggcct ccagcttctc gacgagggcc tccacccggc cgtccgctcc
      241 ggcgccttcg gccaccaggg acccggcgga gtcgcctacc aggcctggcc gcaggccggg
      301 gccggggccg ccctggtccg cagccggctg acggcggggc ccggcgcgcg ggtcctggac
      361 gaggtggcgg gcgcggtggc acgggcgttg cgcaccggct gaccccgcag ccggcgcggg
      421 cgctgcggac cggctgaacc acggcaacgg gaagggccgg aacccgcctc aagcaggttc
      481 cggcccgcac cccgccgggc cgtcaggccc gccccgcccg ccgtcccgcc gggtccgcgg
      541 cgaggccgtg gaggacgacg tcccagaccg agtcccacac cgagtcccag gccgggtccc
      601 gggtcgcgtc gtgcgcggcc atcgcgccct ccgccaggtg cgccagcagc gccacggcgt
      661 cctcgggcga cacgcccgga cggagccggt ccgcgccgtg ggcccggtcg agcagaccgc
      721 ggagcaccgg cagccagacc tcggccaacg gcggtacgcc cacggggcgg tcggcctcca
      781 ggcggcgcgc ggcgcggacg aagcggtcct ggtgcgccag ccgggccatc gcgccgatca
      841 gcgtgcgcag ttcccgcaac gggtcggcgg cggccgcgag ttcttccata cggtgcgcga
      901 agcgggcccg cccgaccccg cgcacctcct cggccagcgc ggtcttggtt cggaagtgga
      961 aggtcagcgc gcccatcgag gtcgccgccc gccagaccac ccgctggagc gaagcccctt
     1021 cgtagcctct ctcggcgatc tcgtcggcgg ccgcctccaa cacggcctgg cgcgtcctgg
     1081 ccgcccgttc ctgcatgcgc cttctccttg gacctcggca agtagtcgtg ctctgcgaaa
     1141 gaaatataac gaacattctc tatgtttgtt agtctgctca gcgacgctca cctgggaggg
     1201 acctgcagtg acgacgacgt acgagacgcc cggcatggcg acggaccgac cgccgggcga
     1261 cctgtcccgg ctgctcttcg gccacttgca ccgctccgac cagcagcgtt gggggcatgt
     1321 gtatctccag ggactgctgc ggacgcacgg gaagaagacc gtgcgccgga tggcggccgt
     1381 cgtgaccggc tcggaggcgg cgtcggcatc gctgcaccag ttcgtcaatg ccagcccgtg
     1441 ggaatgggcc ccggcgcgcg gcgagttggc ccgctgggcc gcccgctcac tgccggtgcg
     1501 ggcctggacg ctggcgccgg cggtactgcc caagcgcggc aactgctcgg ccggagtgca
     1561 ccagcgcttc ctgccggagg ccggacgcac cgtcaactgc cagctggggc tcggcctgtt
     1621 cctggacgcc gggcgggcgc acgtaccggt cgactggcgg ctcttcctgc ctccccggtt
     1681 cacccgcgac gaagcggtgc gcgaccgggc gaagattccc ccgacgacgc gggcccagcc
     1741 gctgtgggcc cacgccctgt gcctggtcca ggagatgacg tcatggtcga acgggcggag
     1801 cgcgccggtg gtggccgacc tgacctccct gtgcgacgtc gcgccgctgg cgcagcggtt
     1861 gcacggcgac gggcacacct tcgtcctcgc cgtcccgggt cagacggcgg tcgccgggcc
     1921 cgaacttgcg cccggtgacc gggagtcggc gcgcggtctg ctgctgcgcc ggggtgtacg
     1981 gcacccggcg ggggcgggcc ggcaggtcgt ctcgtgcgac gcgccggtgc acggactgcg
     2041 cccggacggc gagcgcgtca gcggggcggg ccggctgctg gccgagtggg acacggccgc
     2101 cgggcgcccg ggccggatct ggctgacgaa catcaccgac cgccatccgg ccgaactgct
     2161 ggagctggcc cggtcacccg gcggggcgca ggaggcgacc cggcgcatgg gcgaggactt
     2221 cggcctcctc gacttcgagg gccgctcctt ccccggctgg caccggcaca tgaccctcgt
     2281 ctcggccgcc tacgcctgca gcaccctgga gggcaggggc cgctgacgcc accgccaccc
     2341 gccaccccct tcgacccatt gcttgcatat acacatatat agcggctgga gcctgaccga
     2401 caggcgccag cactccccag atgattgcat gggcatgtat cttgttgttc atcgcagtcg
     2461 agaaggggag ccgtccatga cgatccagca gcagccacgc gccgcctccg accagaccat
     2521 gtgggaggcc gttctcggcc tgcacgcctt cgtggagcgc cagctcgcgc acgccctgca
     2581 gcgccgctac ggcgtcggcc tctccgagta ccgcgccctg gaggccctca cccaggccga
     2641 gaagggcgaa agccgcatgc aggagctcgc ggaccacatc ggcctgggcc agagctcggt
     2701 gacccgcctg gtcggacgcc tggaaagcgc cggctacgcc tacaaggaca actgcgccga
     2761 cgacaagcgc ggcgtcttcg ccgtcatcac cgaagaaggc cgcaagcgct accaggacgc
     2821 ccgtgccacc tacgccgacg tgctcagctc ggccctcaac accgcgagcg ccgacgacca
     2881 gctcgcccgg gcggtgcagg cgctgcgcag cgccgcctga cacgatcacg gcagacggcg
     2941 ggaggcgtcc ggggtaaccc ggcctcccgc cgtcttttgc atgttcgggc ctgctttcgg
     3001 cccgggagtc cgtgacctgg atcactttcg actctgattt acatgcttga ccatgcaaac
     3061 aataccccgt aggttctctc tcgtagccaa gacagcccat ccaccgaggg gggaccgttg
     3121 ccttcgcctc gcctgttgca ggcattcagc agacatgtgc aggaacagcc cgacagcacc
     3181 gcgctcgtca acgccggaca acaggtcacc tacgcggacc tggagcggct gacccgccgc
     3241 gccaccgcgg acctcgaggg cgccgggttc ggattcgtcc gcgccctgtg cgtcccggcc
     3301 cacaagtcgc cggagaccat cgcgctgctg ctggcggcct ggcgtcaggg gatcaacacc
     3361 ctggtcccgt cgcccgccct gggcgccgcc gccctgtcca cgctcatcgc ccaggcccac
     3421 ggcccgctct cggccaccgc ggtccccggc ggcggtgtga ccctctcgcg ggaggaggcc
     3481 gaccccgcac tggcggacgg cttcggcatc cccgaccccg cggagtcgct gctgaccctc
     3541 accacctccg ggtccaccgg cgtacccaag ctcgtccccg tccgtaccga ggccttcgac
     3601 cgcttcgccg actgggccgc caccgcgttc ggcatcgacg gcggcaccac ggcgctgagc
     3661 ttctcgccac tcaacttcga cctggcgctc ctcgatgtct ggacggtgct ggaggcaggc
     3721 ggaacggtcg tcctggccga cgccggggcc agcggcgacg ccggctatct gcgcgacctc
     3781 gcccagcgca acgaggtgac cctggtccag ggcgtgcccc tgctgcaccg gctcctcgcc
     3841 gccgacggcg cccgctatcc agcggtccgt acggtcgtgt tcaccgggga ggccgtctcc
     3901 gaacaggggc tgcgggacac gttcgccgcc tgcccggccg cccggttcca caacgtcttc
     3961 ggctgcacgg agaccaacga cagcttcatc cacgacatcg acccggacgc gtacacgcac
     4021 ccgctgccca tcggcgtccc gatcgacggc accgacgccg tgctgctgat cgaggggccc
     4081 gacggcaccg aggtcctgcg cggtcccggc accggcgaac tgctggtgca cacgcccttc
     4141 cagacctgtg gctatctgga acaggcccgc aacgcccacg cgttcatgcc ggacccgcgc
     4201 ggcggcggcg ccatgttcta ccgcaccggc gacctcgtcc accgtgacgc cgacggccgc
     4261 cacttcctcc agggacgtac cgacttccag gtcaaggtgc gcggcgtgcg caccaacacc
     4321 ctggaggtcg agaccgtcct cggcgcccat ccggacgtcg tcgaggcggc cgtcgtcgcc
     4381 ctgccctgcc ccgaggccgg cacccggctg cacgccgaag tggtgcgccg ggacggcacc
     4441 tccctcagca ccttgggcct gcgggcgtac gcggcgaagc atctgccgcg gcacgccgtg
     4501 cccagctcgg tcgggctcgc ccgcactccg ctgccgaaga ccccgaccgg caaaccggac
     4561 cgtaattcga tcaagaacac ccaactgaac ggagcctctt gatgagcacc gcgagcacca
     4621 caagcaccac ggccgacacc gccaccacgg gcaccggtgg cgacgacccg atccgcgact
     4681 acatcgtcca ggagttcctg ggcggcgagg acgccgcgga cctgaccgac gacttcgacc
     4741 tcatcgagag caccgtcgtc aacagcctcg gcctggtccg cctcatctcc tggatatccg
     4801 agacgtacgg catccccgtc gacgacatcc cgctggaacc ggccgcctac cgcacgctcg
     4861 cggacatccg cgacttcgtc ggcaaggccg ctcccgccgc cgtctgacgg ccaggtctcc
     4921 caccggcctc tccaagcgca ccaccagcac cagcaccacc cgtccagaac tcagcgatga
     4981 cagatgacag gagtactccc atgatcgtcc gttctctctc cgacgtcccc gcggtcgagt
     5041 ggggcagcgg caccagccac cgtctgctca ccgaggccga cgggatgggc ttcaccgtct
     5101 gcgagacgct ggtccgccag ggcacctcca gcgcgctgca gtacctcggc cacctggagg
     5161 cctgctactg cataggcgga tcgggcgagg tcgtcaccac ggacggcgcc caccacaaga
     5221 tcacgaccgg gaccatctac gccctggaca agaacgacgc ccaccacctg atcgcctccg
     5281 acgacgagga cctcctcctg gtctccgtgt tcagcccggc gctgcgtggc gacgagaagc
     5341 acgcgctctc cgaggacggc ttctcccgct actgatccgc acggccgggt gcggggccgc
     5401 gacggcgcgg ccccgcaccc ggcgcccgcc tccagtgccc agtgcccagc gaaaggcaag
     5461 gcagaacacc catggcagca gagaacgcca ccgacaccta cggcgtcacc gcgccctacg
     5521 gcgacgagct caacgacgac gtcgcccgct gggaccgcgc cgccgagttc ccgcacgaga
     5581 agtggaagcc gctccagcgg tccgggctct tcaccctccc cttcgcgccg gagtacggcg
     5641 gcgccggccg gacgctcacc gagaccatgg cggcgctgga gggcctcggc cacaccagcc
     5701 gggacgccgg cctgaacttc tcggcgtcca cgcagatcgt cagcgtcggc atcccgctgc
     5761 aggcgttcgg ctcggaggag ctgcgcggcc gctatctgcc gcgggtcacc tccggcgagg
     5821 ccatcaccgc gcacgcgatc acggagccga gccacggctc ggacgtgatg aacatccgga
     5881 ccacggccgt ccgcgagggc gacgagtacg tgctcaacgg cggcaagatg ttcatcacca
     5941 acgccccggt cgccgacctc ttcctgctgt acgtccgcac cggcaagccg ggcgccttcg
     6001 ggctgagcac cttcctcgcc gagcgcggca ctccgggcct gaggatcggc cggccgctgg
     6061 agacgatggg gctgcgcacc tccccgatca gcgaggtcac gctggaggac gtacggctgc
     6121 ccgtcggcaa ccggctgggc agcgagggcg ccggcttcct gatcatggat tacgtgatga
     6181 agcgggaggt cctcttctcc ttcgccgtca acctcggcga gatgacccac cgcctgaagc
     6241 gggtcgtcga acacgccacc acccggcagc agttcggcag cgccatcgga aagaaccagg
     6301 ccgtcgccca caagatcacg gacatgaaga tcgccgtgga gacggcccgc aagtggctgt
     6361 acgaaaccgg ccacaaggtc gagcagggca aggacgcgtc gctggacgtg gccgccacca
     6421 agatcgtggt cagcgaggcc aaccagctca ccgcccagca cgccatccag atcttcggcg
     6481 cccgcggcta tctgaccgac acgggcatcg agcgcgagct gcgcaacgcc acctccggct
     6541 ccatctactc cggcaccaac gaaatccagc gcaactgcat cgccgccctg atgggcctgt
     6601 gacgagaggc atccgcatga ccgacaccct ggcccccacc acgtccgcgc ggccgaccgc
     6661 cgaggaccgc gccgcgtccg agccgccgac cgccgaggac cgcgcccgcc tcacggcggc
     6721 caccgacttc ctggaccacg agcacgagcg cgtcagggcc ttcgtcgaca aggccctgaa
     6781 cgggatcgac cgcgacgccg ccgacccggt cgacctcgcc gtcgccctct actacgcggt
     6841 gcgcgacggc atccactacg aggtctacgg cgccgacctc tcgccgcagg gcctgaaggc
     6901 gtccgccgtc atcagcggcg gcaagggctt ctgcctgcac aagtccgtgg tgtacgccgc
     6961 ctgctgccgc gccgtcggca tccccgcccg gctgcactac agcgacgtcc gcaaccacct
     7021 cgcctccgac cggctgcgct cctacatcgg cggcgacgtc ttcttccacg gtctggccac
     7081 cgtgtatctg gagggccgct gggtgaaggt gaccccggtc ttcaacaagc tgctgtgccg
     7141 gctgtacggc atgaccccgc tggagttcga cggccactcc gacagccttt accacccctt
     7201 cgacgcccag ggccgacaga gcatggaatt cctcaccgac cacggcgact tcgacgacgt
     7261 cccgtacccg ttcgtgatgg agaacatgcg ccgcaagcac ccgaagttcc tggacgagga
     7321 cggcaccggc accgtcggcg gcggctcgct cgccgacgaa gcggcctgat ccgcgcagcc
     7381 tgagccgcgc cgccgtatcc gtacagccgt atccgtaacg ccgtatccgt accgccgcag
     7441 cagaagcacc gcagacaagg agaagacccc atgacgcagt tccaggcccg tgaggacggc
     7501 tgggccgtgg ccgcccgtgt cggtgtcgtc gttccgcacg cggacgtcgg gcccgagtcc
     7561 gagctccagg cgatggcgcc gcgcgatgtg tacatccacg gttcacgcgt ccacttcggg
     7621 gcaatgcgtc ccggcgggga gatggacccc aagatcccgc acgacccggt gcgcgccttc
     7681 atcgacccgc cgttcatcga cgacgccgtc gagctgctcg ccgccgcccc gctcgactcc
     7741 atcgccctgg ggttcaccag ctcggcctac gtcctgggcg ccgacggcga gcagaagctg
     7801 ttcgagcggc tcgccgaccg gacccgcggc atcccgctca ccggcaccac ccacgccgcc
     7861 gcggcgggtt tcgccgctct gggggccgag cggatcgcgc tcgtcaaccc gccgtggttc
     7921 gacgacgagt tgtcggcgct gggcgcctcg tacttcggcg agcgcggctt cgacgtcgtc
     7981 caccacgcgc cctgcggcct gcccagcaac cagaaactga tcacgccgga ggcgctcgtg
     8041 cagtggatcg agtccaccgt cgccccgcag cggccgcagg cggtgctggt cgccggcaac
     8101 ggcatccgcg ccgtggggac catcgcgggc ctggaggagc ggctcgggtt tcccgtactc
     8161 accgcgaacc aggtgctctt ctggcacgct ctgcaccttg ccggcgggac cggggcggcc
     8221 gcgcggatca gcgagtacgg agccctgttc ggcgtccgcc ccgagggcgt gggtgcggcc
     8281 cgatgagcat gctgcccgcg tacggctacc aggccgccgt gcaggagacc tgcgatacgc
     8341 cggagtacca cctcccgctg gtgtgctggc acgacgacgg gaccggtgtg cgcggcctgg
     8401 tgctgtaccg cggcgggctg cgcccggcgg agcaggtacc ggggttccgg cgctatctcg
     8461 cctccgagga cctggagcag cacgccatga ccggcccgtg gccgctgctc gcagcaaccg
     8521 cctgatccga cccgtggcgg gggccggccg ggtccccgcc gcatcaggag ccgtatcgac
     8581 atgacacacg acctcacgtg gtccgacgcg ccgccgggcg aggtcctcga tccggtcggc
     8641 atctggatcg tccgggctcc ggccgggcag cgcctcgcgg ccgacggggc cccgcccgac
     8701 tggctcgacg agaaggagcg gcgccggctg gccgggatac cgcagccggc cggccgggag
     8761 gcctacgcct tcgcccactg ggcgctgcgg agcgtcctcg ggtcctcgct cggctgctcg
     8821 cccaggagcg tgggctttct gcggcagccg tgtcccggct gcggcggggc gcacgggaga
     8881 ccggcgatcc gcgatccgga ccagggcgac gaaccgctgg agttctcgat gtcgcacagc
     8941 ggggaccacg tcgccatcgc ggtcgccgag gccaccatcg gcatcgacat cgagtcctgg
     9001 ccgaccccgg agtccgtcgc cggctatctg ccgttcctcc acccgaagga acaggagtgg
     9061 ctggcgggcc gtccggacga cgaactcgtc cgcgacttcg cccgcctgtg gacccgcaag
     9121 gaggccatgg ccaaggcgac cgggcagggc atggcggccg tcatgaaccg gctggatctc
     9181 accggtcagc cgctcggctg gcgggtgcgg cagctgctgg caccccccgg gtacgaggcc
     9241 agcttcgcgg tcccggcctc ggtgcacgtc gcggtcacgg tgcacgagga gcttccggag
     9301 ccgatgccgg gtccgggtcc ggtgcggaag ccggagcctg tacgggcgtg aatcggggcc
     9361 cggcgcgagc ccggcgcgag cccggcgcac acccccggcc gtgcccggcg cacacgccct
     9421 ggcccggccc cgacccgcgg caggcgggcg gcccgtactc ctcccgnggg ggtacgggcc
     9481 gcccgccgtt ccgcgtccgc acgtgcccta gatggtcacc tccgaggtga agacccggac
     9541 gccgtgctgc tcgaccgaca cgtccacgcg gcgccggccc gtgccgtcgg ggaccggctc
     9601 gccggccacg acgacggccg gggcgtccag ctcgacgtac cgggcgaagt gcgtcctcat
     9661 cccgaagacg gtcgaggagc cgccgccgac ggcgtgcgcc gcctgccggg cggcttcgag
     9721 cagaagcatt ccgggcgcgt gatcgacggc gtggtcgaac agcaccgggt gcgtggggtc
     9781 cacccgcagc atccaccgcc cgggcctgcc gctcgccacc ggtgagagca ccacgtcgtc
     9841 cggggattcg cggtccaccc ggtgcggatc cacgggcggg ccggccggca ggcagctcgc
     9901 gagggcggcg tcggcatcgg cgtagctccc gcgcagccgc cggtacacgg ccgcgggctg
     9961 gttgttgaac cgggtgtgcg cgctgcccat cagccggtcc cccaggtgga cgtcgatgtc
    10021 catcgtcatc ccggcgaacc tgctgccgcg gcggaccacg tccgagcagg tcaccaccag
    10081 gcgtacctcc tcgtccacgg tggtcaccag cgaggccagc gggtcgaccg agaagctgaa
    10141 gtgctcccat gcctgtttgt acgcgcgcgg cacgtcgtgc acggcgtggg acagcagcgg
    10201 caccgtctgg cgcacgctct cggcgaacag catcgggtcg tacgcccccc gcgtcggccg
    10261 gtagaaggcg tgcccccggg gccagcgccc cgtgagcgca tagtgcccgg gcgaccgctc
    10321 ggcccacgcc gtgagcagga cttcctctct ccgaagcttg tgcacctgcc attggtgcac
    10381 ctgcgactgc tggaccggcg ggaattcacg gctcagtaca gaaacagaca acttggcccc
    10441 ccaagatcgg tagctgttgc gggtgactac gcagcgatgc gtgcggacga ctccgtgtac
    10501 ccggctcaaa aataatgatc cttctgtttt ctcgcgtcaa ggggctgcgg cgccttcctg
    10561 tgtttggcgg atgattgacc ttcatacaca actcaaccac cacaaaatgg acttgcctcg
    10621 atcgcggtcg gctcaggtaa cgtaaggagc attctttttg gaaggtgaga gatatggcgc
    10681 aactgaaaca ggagcgggcg gaacagaccc gccgcgtact cctgcacgca gccgcagagg
    10741 tctttgacga gttcggttat gcgggggcca gcatcacccg catcctgaag cgcgccggcg
    10801 ttacggcagg agcgctctat ttccacttcg gctccaagga ggacctggcc agggcggtga
    10861 tgaacagcca gccggagacc ctggtcccgc tgatcgccgc cggtggtctg cagcggctca
    10921 tcgacctcac cctcgtgtgg tcgtggcagc tccagcgtga cccgctgctc cgggccggcg
    10981 tacggctgac gaacgaacag gccgccatgg gcggctcgtt gaacgccgac ccgtacgaca
    11041 acttccgcgg gatcatgacc ggctgtctgc acgaggcgcg ggaggagggc gagctccagc
    11101 cgggcatcga tccggtcgtc gtcgcggagt tcgtggtcgc cgcctgtacc ggaatgcaga
    11161 tgtactccaa cgtcatcagc ggccgcaagg acctgcccga gcgcacccag cagatgtgga
    11221 acctgctcct cccgggcatc gcggtcccgt ccgtgatcat ccgcgccgac gcgaccccgg
    11281 cccggggcat ctccctgatg cccggcacac cggaacggac cggaacaccg gaacaggccg
    11341 acgcgcccgc accgaccgag gcgcccgaac agcccggttg accggaacag cccggatcac
    11401 ccgaaccggc cggctccccc tcgccggccg gctcggcccg aacggcccgg cccgccctga
    11461 ccgcacagct cgtacagcac gcccagctcg ccccgactgc cctgcccgcc ccgtccgttg
    11521 tcgacgattc ctacggagcc gcatgctttc cctgcgcctg gccgccctga acatcgacgg
    11581 tgtcctgctc aacgacacct tcagcccggt catccaccac ttcatcgtca gcagaggcgg
    11641 tacgtactcc gccgagctgg agagatccat attctcccag ccgcagcaca tcgccggccg
    11701 gctgctctca gccgccgtcg gcggcgacat gacgggcgag gaggcgctcg ccgcctactt
    11761 cgaggaccgc gccgcccacc tggaccgcca cccggtcacg gtcacgccgg gcacccgcga
    11821 cctgctcctg cggctgcggg ccgcgggcct gctcaccgtc tgctacggcg gcctcggcaa
    11881 ggaccacttc gaccggcatc tgggtcactg cgccgagctg ttcgacggcc ccggctacgt
    11941 ctgcaccaac gacatccgcc ccggcgtccg ggagatcacc gaggacgtgt tcgggctccg
    12001 tcccgcccag gccctcttcg tcgacgacgt cgcccgggtc gccgacgcgg cccgcgagct
    12061 cggcaccgcc ttcgtcggcc gcccctccga cttcgtccac agccaccagc gcgcgctcat
    12121 gcgggagtcg ggcgtacgcc acctgatcgg cggcctcgac gaactcgacg acgatctggt
    12181 gcgccggatc gaccgggaga cggtcacggg gagcctgtgg agcactcccc tggccacagc
    12241 cgggcagggg acgtacgcgt gatgccgggc ggaccgctgc tgcccggcaa ggtggcgctg
    12301 atcaccggcg cctccagcgg gatcggcgcg gcggcggccc ggcacttcgc cgacgaagga
    12361 gctgccgtcg tgctcgtggc ccgccgggcc tgcctggtcg aggaggtcgc cgagcggatc
    12421 aggaaggacg gcggccgggc cgtggccgta ccgggcgatg tcaccgtccg ggcggacatg
    12481 gagcatgcgg tcgccacggc ggtcgaccgg ttcggcaggc tcgactgcgc gttcaacaac
    12541 gccggttacg ccagcgccgg aacggtcctg cacgaactgc ccgacgatgt cttcgaccgc
    12601 accatggacg tcaatctgcg cggtgtgtgg aactgtctgc gcgcccagat ccccgccatg
    12661 ctgccggccg gcgccggctc ggtcgtcaac acctccagcg tcgcgggcgt ccgcgcgacc
    12721 gccgcatcgg cgccctacgt ggccgccaag cacgcggtga tcgggctgac gagggcggcg
    12781 gccgccgagt acggcgagca cggcatccgc gtcaacgccc tcgtggtggg cagcaccgat
    12841 acggagatga tggacggcgt cctcgcggcc ggccccaccg tgcgcgccgg cttcggctcc
    12901 aaggcgatcc agcagcgcct cgccgatccg acggagatcg cccgcgccgc ggcctggctc
    12961 tgctcggacg cctcgtcgtt caccaccgga tccgccctcg cggtggacgg cggacgaacc
    13021 gcgaagtgag cgccgcggcc accgcacgcc caacgcccca ggcgcccgct gcccttgtcg
    13081 gtgagggcag gaggcgcctg gggcgtgctg tcggcgaaac gccggacctg aaccgcgccg
    13141 ggtcagaccc ggaccgcgct cggctcgccc gcgagctgcc cggactcctg ggccggggcg
    13201 gccgcctcgg gcttcgtacg gtcggcgagc ttgagccaga tgaccccgac gatgatgacg
    13261 gccagccagg cgcccttggc cagggtgagg gtctcgtcga agaagagcgg gccgagaaca
    13321 gcggcgccga ccgcgccgat gcccgcccag acggcgtaac cgatgctcac gtcgatcgta
    13381 cggagggcga ggctcagcgc gtagagggtg agcaggaaga acaccacggc gaccagggac
    13441 caggtcagga cggtgaagcc ttcgctgccg ccgacggcga gcgcgtaccc gatctcgaag
    13501 actccggcga gaaggagcga gagccaggcg ttggtggagc tcttggctgc gttggacatg
    13561 ggaggtgggt cctctctcag gggtgtcgtc aggtggttac ggggcggagc gcggtggatg
    13621 cggggcccgg gggggggcgt gctccgggct caggcggaac cgctcagctg caggccgacg
    13681 acaccgccga tgacgaggag gatgccgatc gccttgttca cgttcagacg ctggccgaag
    13741 aacagcgcgc cgaggatggt gatgccgaca ccggcgacgg acgtccacag ggcgtagccg
    13801 acgccgacgt cgaaggtcag cagcgccttg ctgaggaaga aggtcgcggc ggcgccgctg
    13861 agcagcgtga tggtggtcca cttgcggttc ttgaagccct cggccttccc ggcggcgatg
    13921 gcgaccgtga tctcgaaggc gacggcgatg gcgaggtaga gccagtgcat ggcgggtcct
    13981 tccgtgcggt ggatgagagg gggtgagcgg agtgaagggg cggtgcggag ccggagcgct
    14041 agcgcgcggc gcggctcagg gtgaggaagt cctggaacgg ctgttcggcc tcggggagtt
    14101 ggagcgccgt gaccttgatg ggccagtccg ccggatcctc ggcgaagagg gtgtacgtgc
    14161 tcgtgtagtc gaagccgtac cgggccgcgg tcctgcggtc ggcggcgtgc acgatgtggc
    14221 cgatgccggc gtaccgcgcc gccagatagc agagggcgca gggttcaccg gaggcgatca
    14281 gggtggctcc ggccacggag cggatcccgt gcttggtggt ggcctcccgg agggcgacca
    14341 cctcggcgtg cgcggtcggg tcgttgtcct cgcgtacccg gttgaagccg gttccgagga
    14401 tccgcccgcc ggccacgacc acgccggaga aggggattcc gccctgcgcg acatgctcac
    14461 cgctgagccg gatcgcttcg tgggcgtagc ccatcagttc gctttcgtgt gtggccatga
    14521 gcggttcgtc tcccgagttg ccctgtagcg ttcgtttgcc tgcacatgca aaagaaagat
    14581 atccgcacgt ggccgccagg ggcctcgctc gcagaactaa tcttgcatgt gcatataaaa
    14641 actgtcaagc gtgtgcgtgc gcccgggcgt tgcccagggt cgccagcggc tccagcaccc
    14701 gggggtcgaa cgccgcccgg gccgtacccg ccgccactct gcgcggcagg tcggggttgg
    14761 ccagcgcggc cgtcccgatc gccaggaggt cggcgtgccg ctcgtccagg acgcggcgtg
    14821 ccacctcgtc ccggtgcagc ccgccgttgg cgatcacggg gagcccggtg accgtccggg
    14881 cgagcgcgga aagcgtccgc ccctccggga accagtcccg tccactgccc gcgagatgca
    14941 gatagccggc cccggcggtg gcggccgccg tgaagacggt gcgcgcctcg gcttcgccgc
    15001 ccggccactg ccacgcgggg tcgttgatct tcccctggga gagccggaca ccgaccgtga
    15061 agccgggccc ggtcgcggct ctcaccgcgg ccgtcacctc ccgtaccagc cgcaggcgtt
    15121 cctcgacgtc gccgccgtac tcatcggtgc gcacattggt gtacggggtg aggaactggt
    15181 cgagcagata gccgttggcc gcgtggatct ccaccccgtc gaagccgacg tcgcgggcgc
    15241 ggaccgcggc ggccgcgaag ccctcgacgg cctcggcgat ctgccggcgg gtcatctcca
    15301 tcggcacggg ccagcggccg ctgccacggt atttggccag ttgctcgccc agcggccgca
    15361 ccgccgacgg tcctgcggcc cggtcgcgga accggttgcc ctgcgagagg gccccggcgt
    15421 gcatcagctg c
//
