LOCUS       NZ_JALDPQ010000054     18111 bp    DNA     linear   CON 28-MAY-2024
DEFINITION  Streptomyces sp. TRM75563 716, whole genome shotgun sequence.
ACCESSION   NZ_JALDPQ010000054
VERSION     NZ_JALDPQ010000054.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TRM75563
  ORGANISM  Streptomyces sp. TRM75563
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 196044)
  AUTHORS   Chen,Y.
  TITLE     Streptomyces aheensis sp. nov., isolated from road
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 196044)
  AUTHORS   Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2022) College of Life Science, Tarim University,
            Hongqiao, Alar 843300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 14-MAR-2022
            Assembly Method                   :: ABySS v. V2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022748615.1-RS_2024_05_28
            Annotation Date                   :: 05/28/2024 05:18:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,476
            CDSs (total)                      :: 7,413
            Genes (coding)                    :: 7,165
            CDSs (with protein)               :: 7,165
            Genes (RNA)                       :: 63
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 249
            CDSs (without protein)            :: 248
            Pseudo Genes (ambiguous residues) :: 1 of 249
            Pseudo Genes (frameshifted)       :: 108 of 249
            Pseudo Genes (incomplete)         :: 202 of 249
            Pseudo Genes (internal stop)      :: 19 of 249
            Pseudo Genes (multiple problems)  :: 75 of 249
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:22:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 18111
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALDPQ010000054.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..18111
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..18111
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..18111
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[7049:8111](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7050..8111
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(<1..1457)
                     /locus_tag="MQC87_RS10460"
                     /old_locus_tag="MQC87_10460"
     CDS             complement(<1..1457)
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544794.1"
                     /locus_tag="MQC87_RS10460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10460"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_242738328.1"
                     /transl_table=11
                     /translation="MEHEALTELAVIRAEALRGPSERATEAQHAKGKLTARERIGLLLD
                     PGSFKEVEQLRRHRATGFGLEAKKPYTDGVVTGWGTVEGRTVFVYAHDFRIFGGALGEA
                     HATKIHKIMDMAISAGAPLVSLNDGAGARIQEGVSALAGYGGIFQRNTCASGVIPQISV
                     MLGPCAGGAAYSPALTDFVFMVRETSQMFITGPDVVKAVTGEEITQNGLGGADVHAETS
                     GVAHFAYDDEETCIAEVRYLIGMLPSNNRENPPTVPSDDPADRRGDVLLDLVPADGNRP
                     YDMHQVIEELVDDGDYLEIHERWARNIICAMARLDGQVVGIVASQPLALAGVLDINSSE
                     KAARFVQLCDAFNIPLVTLVDVPGFLPGVDQEHGGIIRHGAKLLYAYCNATVPRISLIL
                     RKAYGGAYIVMDSQSIGADLTYAWPTNEIAVMGAEGAANVIFRRQIADAEDPEAMRTRM
                     VKEYKAELMHPYYAAERGLVDDVIDPA"
     gene            1449..2216
                     /locus_tag="MQC87_RS10465"
                     /old_locus_tag="MQC87_10465"
     CDS             1449..2216
                     /NRPS_PKS="Domain: ACPS (82-146). E-value: 5e-08. Score:
                     24.8. Matches aSDomain:
                     nrpspksdomains_MQC87_RS10465_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013786.4"
                     /locus_tag="MQC87_RS10465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10465"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_242738329.1"
                     /transl_table=11
                     /translation="MLHGRSPPRPVLRSGQHPAGARRILAELLGVAPDAVALGRLPCPG
                     CGAADHGPPAVLHPRSPFRISLSHASGRCLLAVAQVPVGVDIEVERPVKIDELARVALT
                     ATEHRQLLGRPAGAARDRAFPRCWTRKEAALKALGTGIATDLSRIETHPDRRGPVTVTA
                     GPPGTARDWSVHDVTIPGPWVATAAVPHGVSARVTVSRHPGIPASRSALANFPSPFAPV
                     RFPSAQYHVHPPARELPLGRAIVRSSAAHWTRS"
     aSDomain        1695..1886
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MQC87_RS10465_ACPS.1"
                     /evalue="5.00E-08"
                     /label="MQC87_RS10465_ACPS.1"
                     /locus_tag="MQC87_RS10465"
                     /protein_end="146"
                     /protein_start="82"
                     /score="24.8"
                     /tool="antismash"
                     /translation="VGVDIEVERPVKIDELARVALTATEHRQLLGRPAGAARDRAFPRC
                     WTRKEAALKALGTGIATDL"
     misc_feature    2082..2084
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2368..3831)
                     /locus_tag="MQC87_RS10470"
                     /old_locus_tag="MQC87_10470"
     CDS             complement(2368..3831)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514147.1"
                     /locus_tag="MQC87_RS10470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10470"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_242738552.1"
                     /transl_table=11
                     /translation="MHRLARSGGTAELLRWLAGRAEGWAGLVGPDGTVLHAAARTERVV
                     APDVAGLVAEGANALTERGARAYSLDTGAHTTLLFPLSADDPAAPVLVVVAPRPVAAGL
                     ATLLADVVLPLALCLQAETLERKRRRVDLAESRGREAVLHLLMTGQLSIAQQVAGALRP
                     RLPDPVRVCVVECSGDGRDEVARVCAEADGGRSWIVRCPVYARHLILVMPAEVTEPDAV
                     ATDEAVAARVGDCVVGVSEPVPLADTATGYRQAFHALAVARELPARHARFGVSPDPALV
                     VGPAGRQWADELLTPLLTHVPRRTQDPGSQELAATAVSWLAFSSHATDHLKVHRNTLAA
                     RLKLIGELLGLDLHRLSDQAALDLALRVRATPAPACTPEPVPYTTGGPGPRETAQGLDA
                     VLRRPAVRDWADQQLAPVLGSEETLRAWLRCEGRLGPAAVELGISVPGARKRLTRLETV
                     LQRSLLRPPSARYDLWLALRAHDLAAEPR"
     gene            4229..5344
                     /gene="dnaN"
                     /locus_tag="MQC87_RS10475"
                     /old_locus_tag="MQC87_10475"
     CDS             4229..5344
                     /EC_number="2.7.7.7"
                     /GO_component="GO:0009360 - DNA polymerase III complex
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /gene="dnaN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379866.1"
                     /locus_tag="MQC87_RS10475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10475"
                     /product="DNA polymerase III subunit beta"
                     /protein_id="WP_242738331.1"
                     /transl_table=11
                     /translation="MEFRIERSALTEAVAWAARVLPVRSPVPVLGGLLLDTAGEGGRLR
                     ISGLDYEASARIDVDAEVVRPGRVLVMGRRLLDICKVLPEGPVECAVEGSRFTVAGDGA
                     RFGLSVLPLDDYPALPALPQVRGAVDAELFASAVADVAVAAGRDDTLPALTGIRLGLDG
                     DTMTLAATDRYRFAVRTLPWKATAPGESADVIVSARRLTEIARSLGRSGLVSVALDAGS
                     AGFEHAGMRTTVRLLEGRLPRHEKLFAMTDPAVAVVDRARLTEAVKRVSVVADGDSPVQ
                     MTFSRADASVLLRAGYEDDVASQRLPAVLEGPGELTVAFNPGYLADALASFTDPSLRLL
                     LLGAGQRAMITDEAGTDAHRHLLMSVKPQLA"
     gene            complement(5465..6352)
                     /locus_tag="MQC87_RS10480"
                     /old_locus_tag="MQC87_10480"
     CDS             complement(5465..6352)
                     /GO_function="GO:0004568 - chitinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006032 - chitin catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0016998 - cell wall macromolecule catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452937.1"
                     /locus_tag="MQC87_RS10480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10480"
                     /product="glycoside hydrolase family 19 protein"
                     /protein_id="WP_103510564.1"
                     /transl_table=11
                     /translation="MIRRVMALLVALGAIVAALVVLPAATAQAATCATAWNSSAVYTGG
                     GTASYNGRNYTAKWWTQNETPGSSDVWADNGACGTGGGEDPGQSNGFVVSEAQFNQMFP
                     NRNPFYTYQGLTDALSAYPAFANTGSDEIKKREAAAFLANVSHETGGLVYIKEVNEANY
                     PHYCDASQPYGCPAGQSAYYGKGPIQLSWNFNYKAAGDALGIDLLNNPYLVEQNAAIAW
                     KTGLWYWNTQSGPGTMTGHNAIVNNAGFGETIRSINGAIECNGGNPAQVQSRINKFTQF
                     TQLLGTTTGSNLSC"
     misc_feature    complement(6426..6441)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.22"
                     /tool="antismash"
     misc_feature    6442..6457
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.24"
                     /tool="antismash"
     misc_feature    6550..6563
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            6770..7057
                     /locus_tag="MQC87_RS10485"
                     /old_locus_tag="MQC87_10485"
     CDS             6770..7057
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514142.1"
                     /locus_tag="MQC87_RS10485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10485"
                     /product="hypothetical protein"
                     /protein_id="WP_242738333.1"
                     /transl_table=11
                     /translation="MERTAHTHEGVGGPGEQAVLLAAGLADLAVTTVGSALTSVRGLLR
                     RSDTAELAAEAEQDLIARGRLALGRYTSTPPAHLEVLARHVIAQRDGDRA"
     gene            7050..8111
                     /locus_tag="MQC87_RS10490"
                     /old_locus_tag="MQC87_10490"
     CDS             7050..8111
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240939.1"
                     /locus_tag="MQC87_RS10490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10490"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_242738335.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5.7e-35, bitscore:
                     114.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEAWEPSAFKARVDQVLHRFASEEAEQLIAVDASLSPVAEAVET
                     AVADGKRLRAAFCYWGWRAAGQPDSDALVRAAASMELVHAAAVVHDDLIDDSPLRHGKP
                     TAHLALREAVKGHPEPAPAARSLAMLAGDLLISMAGQLFVTSGLPAAYVSRARPLWACL
                     ARELVAGECLEILHTGGADPDTAVSLKVVRYKTAKYTVEQPLLIGALLGGAGERLRAGC
                     SAYGLPLGEAFQLRDDLLGLFGDPALTGKDGSDDVRGHRPTALLAETWRLAGEEDRARL
                     RALLAPATGTCTAGTTDAVRDVMRRLKAPDRIEAMINARVEEALSALDELDLPGPGATA
                     LAGLAHSASVRRH"
     gene            8148..9335
                     /locus_tag="MQC87_RS10495"
                     /old_locus_tag="MQC87_10495"
     CDS             8148..9335
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514140.1"
                     /locus_tag="MQC87_RS10495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10495"
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_242738337.1"
                     /transl_table=11
                     /translation="MTSAPAPNYTKASLDALRQSGDELADATVAALFERGEVGTFNTLM
                     RYVSTAGAPLPDGLPDVAREYLDATAAPPPWVDWDEMEKARLFFIDNNVHISTALSFAS
                     MPACYVVPHVAKLLSATHGLNYPSKRMAETGQFTVYLMRPDAFEAGSRFVPAAQKVRLL
                     HASIRHHLRREGVWDAESQGVPICQEDMIGGQMFFSMLVLDSLHRLGIHMSEEGAEAYY
                     YAWRVVGAMLGVDQQAVPKSLAEAREFLDLYMIRHMGPSPEGALLTRQLIDLYEEVVPG
                     TFFDPIVSALIRHLVGDTCADWLEVPRTPWDTVAKAVPHLLGVLETIEDRSPLGAWALD
                     RIGHLTTVLELSSLTRGRVMHYAIPEHLKKEYGVPSGPARTGRWSPPAATVPGPR"
     gene            complement(9568..10851)
                     /locus_tag="MQC87_RS10500"
                     /old_locus_tag="MQC87_10500"
     CDS             complement(9568..10851)
                     /EC_number="6.3.4.4"
                     /GO_function="GO:0004019 - adenylosuccinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006164 - purine nucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975310.1"
                     /locus_tag="MQC87_RS10500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10500"
                     /product="adenylosuccinate synthase"
                     /protein_id="WP_030082081.1"
                     /transl_table=11
                     /translation="MPALVLLGAQWGDEGKGKATDLLGGSVDYVVRYQGGNNAGHTVVV
                     GDQKYALHLLPSGILSPGCTPVIGNGVVVDPAVLLSELSGLNERGVDTSKLLISGNAHL
                     ITPYNVTLDKVTERFLGKRKIGTTGRGIGPTYADKINRVGIRVQDLYDESILEQKVEAA
                     LEQKNQLLAKVFNRRAIEAGKVVEDMLQYAEQIKPFVADTTLILNDAIDEGKVVLFEGG
                     QGTLLDVDHGTYPFVTSSNPTAGGACTGAGVGPTKISRVIGILKAYTTRVGAGPFPTEL
                     HDEDGEALRRIGGERGVTTGRDRRCGWFDAPIARYATRVNGLTDFFLTKLDVLTGWEQI
                     PVCVAYEIDGKRVEELPYNQTDFHHAKPIYENLPGWSEDITKAKTFSDLPKNAQGYVKA
                     LEEMSGAPISAIGVGPGRTETIEINSFL"
     gene            11038..11922
                     /locus_tag="MQC87_RS10505"
                     /old_locus_tag="MQC87_10505"
     CDS             11038..11922
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010063221.1"
                     /locus_tag="MQC87_RS10505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10505"
                     /product="diacylglycerol kinase"
                     /protein_id="WP_242738339.1"
                     /transl_table=11
                     /translation="MSAAEPPGDGDDQLLVVIDPVARRTDGESVRIAKDVLSAGSHAKI
                     CLPDTPEEFARALSRRGARRPVVVGDDHALLRAVAQLHRERELADGVLSLIPVGAAHAL
                     EVAHALGVPRGAVAAARTALDGAVRRLDLLVDDSDGVVLGRLRIPAPPPPPPGSGTPHA
                     GVTAVWDTCRSLVSSLVRPAPVAATTNPGTHRLRIEADGVLLSDLDTPVRDLSVTSQGD
                     GGLADVVVRTGSGEDVTAEAKAVTVSGADFRYRADIQTGGPVRTRTWTVRAGAWGLMLP
                     GPASADAAAGARW"
     gene            11955..12227
                     /locus_tag="MQC87_RS10510"
                     /old_locus_tag="MQC87_10510"
     CDS             11955..12227
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961800.1"
                     /locus_tag="MQC87_RS10510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10510"
                     /product="DUF1876 domain-containing protein"
                     /protein_id="WP_006126332.1"
                     /transl_table=11
                     /translation="MTRIAVGWHIDLEFEEDTHRTRAAALVRLSDGTEVRAHGYASRHP
                     SDADQQRVGEEIAGARALNELAMKLLTKAHDEIDEASGRKSYPLT"
     misc_feature    complement(11983..11998)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    complement(12271..12285)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.96"
                     /tool="antismash"
     gene            12309..12650
                     /locus_tag="MQC87_RS10515"
                     /old_locus_tag="MQC87_10515"
     CDS             12309..12650
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961801.1"
                     /locus_tag="MQC87_RS10515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10515"
                     /product="hypothetical protein"
                     /protein_id="WP_103510569.1"
                     /transl_table=11
                     /translation="METENPRREAVVGTAGCVTAFAGALAGIVLWAPHGKGGLLDGFEG
                     ASNWNVLWVGLPLMILGGTAAALAVFFLVRGDWKRALGLLAAIAVLFALGVAVDALAGA
                     PRPECYDPC"
     gene            complement(12676..13881)
                     /locus_tag="MQC87_RS10520"
                     /old_locus_tag="MQC87_10520"
     CDS             complement(12676..13881)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379872.1"
                     /locus_tag="MQC87_RS10520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10520"
                     /product="cytochrome P450"
                     /protein_id="WP_242738341.1"
                     /sec_met_domain="p450 (E-value: 3.1e-22, bitscore: 72.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHVSFDPWSPAFVADPYPAYTALRAAGRAHWFEPTGQWLIPHHSD
                     VSALLRDRRLGRTYLHRFSHEEFGRTPPPAAHEPFTTLNGQGILDLEAPDHPRIRRLIS
                     KAFTPRTVENLAPTVRRLAAELVDAFVAKGGGDLLAEVAEPLPVAVIAEMLGVPEADRG
                     LLRPWSAAICGMFELNPSEETAAAAVRASVDFSAYLRGLIAERRADPGEDLISALIAAH
                     DEGERLTEQEMISTCVLLLNAGHEATVNTTVNGWRTLFHHPEQLAALRADPGLLPTAIE
                     ELLRYDTPLQMFERWVLDDIEIDGQVIGRGAEVALLFGSANRDPERFARPDTLDLSRTD
                     NPHVTFGAGIHFCLGAPLARLELAASFGELLRKAPALRMTAEPEWHPGYVIRGVKELRA
                     EV"
     gene            complement(13936..14604)
                     /locus_tag="MQC87_RS10525"
                     /old_locus_tag="MQC87_10525"
     CDS             complement(13936..14604)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014046920.1"
                     /locus_tag="MQC87_RS10525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10525"
                     /product="response regulator transcription factor"
                     /protein_id="WP_242738343.1"
                     /transl_table=11
                     /translation="MSDTDIRVLIVDDQMMVREGFSVLLNAMPGITVVGEAVDGQQALA
                     QVAALGPDVVLMDIRMPEMNGIEATREIVARDADAKVLVLTTFDLDEYVYQALRAGASG
                     FLLKDASARQLADGVRVVASGEALLAPTVTKRLITEFSKLAETPRPPALARIGDLTERE
                     TEVLVLIAQGLSNAEIASHLIVAESTIKTHVSRILVKLGLRDRTQAAVFAYEARLVTPG
                     "
     gene            complement(14601..15938)
                     /locus_tag="MQC87_RS10530"
                     /old_locus_tag="MQC87_10530"
     CDS             complement(14601..15938)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126328.1"
                     /locus_tag="MQC87_RS10530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10530"
                     /product="histidine kinase"
                     /protein_id="WP_242738345.1"
                     /transl_table=11
                     /translation="MTETQTKNSGPEFRAAAGAIDGLREDLFRQAFAYRPLPPLNPDGR
                     LMRRLPEGLRKGAVWTPHALVLFAAFLVMMAGFAEWQFRLLMGLVPAIAVAMTLIRPVA
                     AFWASMLATVFCAVLGSEGLWGPSAFGAQLVVLVVVAARTRPRTAAWMWLLTLLFGMLL
                     EGGDPSITAPLATLSAFALLVVAVVQIRRDAEREVTVQRTVTAVERDRRTLLEERTTIA
                     RELHDVVAHHMSVVAIQAEAAPYRVENPPPELEQAFVTIRENAVAALTELRRVLGVVRA
                     EDYEAPDAPQPTLAALDGLLDNVRETGLETEKVITGAVRELPQGVELSAYRIVQEALSN
                     SLRHAPGSSARVELGYVLGGLGLRVVNGPPRGLVKPSPGAGHGITGMRERVAMLNGEMT
                     AGTTADGGYEVAVFLPVPLSQEPESRETADGNGETVVIERVQDGRA"
     gene            complement(16069..16896)
                     /locus_tag="MQC87_RS10535"
                     /old_locus_tag="MQC87_10535"
     CDS             complement(16069..16896)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514131.1"
                     /locus_tag="MQC87_RS10535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10535"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_242738347.1"
                     /transl_table=11
                     /translation="MTILVTGATGTVGRRVVEHLLERGEHVRALTRDPARAELPAGVDV
                     VRGDLTHPASLEPALDGVSGLHLITFGGGLFAPLETGEEILGLARRAGVRRVTVLHGGG
                     ATPMESAVRASGFDWTVVMPVEFMANALEWAPGIRSEGVVREPFVDRLSAVVHESDIGA
                     VAAAALTEYGHGGQEYLVTGPQVLTVRDKAAAIGAVRGTDVELVELTEEQALESWRGQG
                     MPEDVIAFLIDVYRDTPPEGRTVLDTVEKVTGRPARTFAQWAEEHAKHFRVQP"
     gene            complement(17002..17925)
                     /locus_tag="MQC87_RS10540"
                     /old_locus_tag="MQC87_10540"
     CDS             complement(17002..17925)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071547.1"
                     /locus_tag="MQC87_RS10540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_10540"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_242738348.1"
                     /transl_table=11
                     /translation="MSDSPGFPDSAARDRDEAESASAFAHPPVAPDATAAYGDHPDQVV
                     DFYAPRDGRTAAPLVVLLHGGAWRAPYDRAHASPLADFLARRGFAVANVEYRRGGDDIP
                     QQRDGAENARPGGADPVAGRWPETFDDVAAALDAMPVLAARELPGADVRRIVVAGHSAG
                     GHLALWAAARHVLPEGSPWRLPVPPPLRGVVALAPIADFATAVGLGVCGGAVDQLLGTK
                     ADFEERAAHADPGVLLPTGIATAIVQGVDDIVVPKAVAEAYVDAAARSGETVGLTLLGG
                     VGHFPLIDPAADACAVVAEEITQLAW"
ORIGIN
        1 tcggcggggt cgatgacgtc gtcgacgagg ccgcgctcgg ccgcgtagta ggggtgcatc
       61 agctcggcct tgtactcctt gaccatgcgg gtgcgcatgg cctcggggtc ctcggcgtcc
      121 gcgatctggc ggcggaagat cacgttggcc gcgccctcgg cgcccatgac cgcgatctcg
      181 ttggtgggcc aggcgtaggt gaggtccgct ccgatggact ggctgtccat gacgatgtac
      241 gcgcctccgt aggccttccg caggatcagc gagatccgcg gcaccgtggc gttgcagtag
      301 gcgtagagga gtttggctcc gtggcggatg atgccgccgt gctcctggtc gacgcccggc
      361 aggaagcccg gcacgtcgac cagcgtcacc agcgggatgt tgaacgcgtc gcagagctgg
      421 acgaaccgtg cggccttctc cgacgagttg atgtccagca caccggccag ggcgaggggt
      481 tgactggcga cgatgccgac gacctggccg tcgaggcggg ccatcgcaca gatgatgttg
      541 cgggcccagc gctcgtggat ctccaggtag tcaccgtcgt cgacgagctc ctcgatcacc
      601 tggtgcatgt cgtacggacg gttcccgtcg gccgggacca ggtccagcag cacgtcgccg
      661 cgccggtcgg ccggatcgtc actcggaacg gtcggcgggt tctcacggtt gttcgagggc
      721 agcatcccga tgaggtaccg gacctccgcg atgcacgtct cctcgtcgtc gtacgcgaaa
      781 tgcgcgacac ccgacgtctc ggcgtgcacg tccgcaccac ccagaccgtt ctgggtgatc
      841 tcctcaccgg tgaccgcctt caccacgtcc ggcccggtga tgaacatctg cgaggtctcc
      901 cggaccatga acacgaaatc cgtcaacgcc ggggaatacg ccgcaccgcc cgcacacggg
      961 cccagcatca cgctgatctg cggaatcaca ccgctcgcac acgtattgcg ctggaaaata
     1021 ccgccgtaac ccgcgagcgc cgaaacgccc tcctggatac gcgctcccgc accgtcgttc
     1081 agcgacacca gcggagcacc cgccgagatc gccatgtcca tgatcttgtg gatcttcgtc
     1141 gcatgcgcct cacccagcgc cccgccgaag atccggaaat cgtgcgcgta cacgaacacc
     1201 gtccgaccct cgaccgtgcc ccaaccggtg accacaccat cggtgtacgg cttcttcgcc
     1261 tccagaccga agcccgtcgc ccggtgccga cgcagctgct cgacctcctt gaacgaaccc
     1321 ggatccagca acagcccgat ccgctcccga gcggtcagct tccccttggc gtgctgcgcc
     1381 tcggtcgccc gctcactcgg tccgcgcagt gcctcggcac ggatcacggc gagttcggtg
     1441 agcgcctcat gctccatggc cggtctcctc ctcgtcctgt cctgcggtcg ggtcagcatc
     1501 cggccggcgc ccgccgcatc ctggcggagc ttctcggggt cgcgccggac gccgtcgccc
     1561 tgggccggct gccgtgcccc ggatgcggag ccgcggacca cgggccaccg gcggtactgc
     1621 atccgcgaag cccgttccgg atcagcctct cgcacgcgtc gggccgctgc ctgctggccg
     1681 tcgcccaggt tccggtcggc gtcgacatcg aggtcgaacg tccggtgaaa atcgacgagt
     1741 tggcacgcgt cgcactcacg gccaccgagc accggcagct gctcggccgt ccggccggag
     1801 cggcccgcga ccgcgccttc ccgcgctgct ggacacggaa ggaagccgcg ctcaaggcgc
     1861 tcggaaccgg catcgcgacg gacctgtccc gcatcgagac gcacccggac cgccgaggtc
     1921 cggtcacggt cacggccggc ccgccgggca ccgcgcgcga ctggtccgtg cacgatgtga
     1981 ccatcccggg accatgggtt gcaaccgcgg cggtgcccca cggcgtctcc gctcgcgtaa
     2041 ccgtttcccg gcatcccggc atcccggcat cccggagtgc attagcaaat ttcccgagcc
     2101 ctttcgcgcc cgtgcggttc ccctccgcgc aataccacgt tcatccgcct gcccgtgaac
     2161 tgccactcgg gcgagcgatt gtccgctcat cggccgccca ttggacacgt agttaaatac
     2221 cgtgcggccg accgtgcgaa aaatgatccg accggtcggt aacctgcatc ggattctccg
     2281 gagaaatccg gaaagcggcg tagagggaat agcggaaaca cctcaccgga caccggccga
     2341 agagtcctgg aacacctgcc ggtacgccta ccgcggctcc gccgccaggt catgggcgcg
     2401 cagcgccagc cacaggtcgt agcgggcgct cggaggccgg agcagcgaac gctggaggac
     2461 cgtttcgagc cgggtgaggc gcttgcgggc gccgggcacg ctgatgccca gctcgacggc
     2521 cgcgggcccg aggcggccct cgcagcgcag ccaggcccgc agggtctcct cggagccgag
     2581 tacgggggcc agttgctggt ctgcccagtc ccgtacggca gggcggcgca gaacggcgtc
     2641 gaggccctga gccgtctctc gcggaccggg tccgccggtg gtgtacggga cgggctcggg
     2701 ggtgcacgcc ggggcggggg tggcgcggac gcgcagcgcc aggtcgagcg cggcctggtc
     2761 ggacagccgg tgcaggtcga ggccgagcag ttcaccgatg agcttcagcc gggcggcgag
     2821 ggtgttgcgg tggaccttga ggtggtcggt cgcgtgcgac gagaacgcca gccaggacac
     2881 ggccgtggcc gccagctcct ggctcccggg gtcctgggta cggcgcggca catgggtcag
     2941 cagcggggtc agcaactcgt ccgcccactg ccggccggcc ggtccgacga ccagcgcggg
     3001 atccggcgag accccgaacc gggcgtgccg ggcgggcagt tcacgggcga cggccagggc
     3061 gtggaaggcc tggcggtagc cggtggcggt gtcggccagc ggcacgggtt cgctgacgcc
     3121 caccacgcag tcgcccaccc gggcggcgac ggcctcgtcg gtcgcgacgg cgtccggctc
     3181 cgtcacctcg gcgggcatca cgaggatgag atggcgggcg tagaccgggc accgcacgat
     3241 ccaggaccgg ccgccgtccg cctccgcaca gacccgggcc acctcgtcgc gcccgtcgcc
     3301 ggagcactcc acgacacata cccgtaccgg atcgggaagc cggggccgca gcgcaccggc
     3361 gacctgctgg gcgatggaga gctggcccgt catcagcaga tgcagcaccg cctcacggcc
     3421 gcgggactcg gcgaggtcca cccggcggcg tttgcgctcc agcgtctcgg cctggaggca
     3481 cagggccagc ggcaggacca cgtcggccag cagcgtggcg agcccggcgg ccacgggccg
     3541 gggcgcgacg acgacgagca ccggcgcggc cgggtcgtcg gcgctcaggg ggaacagcag
     3601 ggtcgtgtgc gcgccggtgt ccagcgagta cgcccgggcc ccgcgctccg tgagggcgtt
     3661 cgctccctcg gcgacgagcc ccgcgacatc gggcgccacc acccgctccg tccgggccgc
     3721 cgcgtgcagc accgtcccgt cgggcccgac gagcccggcc cagccctcgg cccgcccggc
     3781 cagccagcgc agcagctcgg ccgttccgcc ggagcgggcc agccggtgca tccgcagcag
     3841 atcgtccgca cgctcctgtg ctcgcatccg tcccccgttc ctgcccaggg cacagccgcg
     3901 gtacgggtgg accacccggc ccgactgtgc ggaccgatac ccccgtggcc gccccactgg
     3961 gcgtattgaa cctcccggtt ccctacccgc cgttctatcg tccgaacgtg ttccggcacg
     4021 tcgggggaga cgggggaaag ccggaacgct cggggcgcgg cggcagcggc tcacgggggt
     4081 ggtcgctgtc gccggttccc ggccggcgca ccgccgcccg ggcccgacgg ccggccccgg
     4141 ttgtcagtgg tgcctcctaa cgtcgtacgc agaagtcggt tccccccttc cggcctccgg
     4201 ctcccgacgt ccgaggaaag gcgcccccat ggagttccgt atcgaacgca gtgccctgac
     4261 cgaggccgtg gcctgggccg cccgtgtgct gcccgtacgg tcacccgtcc cggtgctggg
     4321 cggtctgctg ctggacacgg cgggcgaggg cgggcggctg cggatctccg ggctggacta
     4381 cgaggcgtcc gcgcgtatcg acgtggacgc cgaggtcgtg cggcccgggc gggtgctcgt
     4441 catggggcgg cgtctgctgg acatctgcaa ggtgctgccc gagggccccg tggagtgcgc
     4501 ggtggagggc tcgcggttca cggtcgcggg cgacggcgcc cggttcggac tctccgtgct
     4561 gccgctggac gactacccgg cactgcccgc gctgccgcag gtccggggcg cggtggacgc
     4621 ggaactgttc gcgtcggccg tggccgatgt ggcggtggcc gccggtcgcg acgacaccct
     4681 gcccgcgctc accggaatcc ggctgggcct cgacggcgac acgatgacgc tcgccgcgac
     4741 cgaccgctac cgcttcgccg tacgcaccct cccgtggaag gcgaccgccc ccggcgagag
     4801 cgccgacgtc atcgtctccg cccgccgcct caccgagatc gcccgctcgc tgggccggtc
     4861 cgggctggtg agcgtcgccc tggacgccgg ttcggcgggc ttcgagcacg ccgggatgcg
     4921 gaccaccgtg cgcctcctgg agggccgtct gccgcgccac gagaagctgt tcgcgatgac
     4981 ggacccggcg gtcgcggtgg tggaccgggc ccggctgacg gaggccgtca agcgggtctc
     5041 cgtcgtcgcc gacggggaca gcccggtgca gatgaccttc tcccgcgccg acgcctcggt
     5101 cctgctccgg gcgggttacg aggacgatgt ggcctcccag cggctgccgg ccgtcctgga
     5161 ggggcccggg gaactgaccg tggccttcaa ccccggctat ctggccgacg ccctggcctc
     5221 gttcacggat ccctcgctgc ggctcctgct gctgggggcc ggccagcgcg cgatgatcac
     5281 ggacgaggcg ggcacggacg cccaccgcca cctgctgatg tcggtgaagc cgcagctggc
     5341 gtgagcgctg cggctcctcc tcggcgtgcc ggacgccgaa acggggggtg gcccggcgtg
     5401 agccggacgc accccccgtt cgggtggggt cctcgggaac ctcaggggcc ctcgcgggcc
     5461 ggagtcagca gctcaggttg gagccggtgg tggtgccgag aagctgggtg aactgcgtga
     5521 acttgttgat ccggctctgg acctgggccg ggttgccgcc gttgcactcg atcgccccgt
     5581 tgatggagcg gatcgtctcg ccgaagccgg cgttgttgac gatggcgttg tggccggtca
     5641 tcgtgccggg gccggactgg gtgttccagt accagaggcc ggtcttccag gcgatggcgg
     5701 cgttctgctc cacgaggtac gggttgttca gcaggtcgat gcccagcgcg tcaccggccg
     5761 ccttgtagtt gaagttccag ctcagctgga tggggccctt gccgtagtac gcggactggc
     5821 cggccgggca gccgtagggc tggctcgcgt cgcagtagtg cgggtagttc gcctcgttga
     5881 cttccttgat gtacaccagc ccgccggtct cgtggctgac gttggcgagg aaggcggcgg
     5941 cctcccgctt cttgatctcg tcgctgccgg tgttggcgaa ggccgggtag gcgctgaggg
     6001 cgtcggtcag gccctggtag gtgtagaagg ggttccggtt cgggaacatc tggttgaact
     6061 gggcctcgct gacgacgaag ccgttgctct ggcccgggtc ctcaccgccg ccggtgccgc
     6121 aggcgccgtt gtcggcccag acgtcggagc tgcccggcgt ctcgttctgg gtccaccact
     6181 tggcggtgta gttgcggccg ttgtaggagg cggtgccgcc tccggtgtag accgcggagg
     6241 agttccaggc cgtggcacag gtggcggcct gcgcggtggc ggcggggagg acgacgagcg
     6301 ccgcgacgat cgcgccgagc gcgaccagca gggccatgac acgtcgaatc acgtgatcac
     6361 actccttaga cgcggcgcga cgtccggccg tgcgccgccg tgggggtgcc cgacactcaa
     6421 gcgaggatgg tctggacctg tcaaggtcta gaccaggcct gtcgaatgcg cccccgccct
     6481 ccgccggccg cccaccgccg tggaccacga gcgcaccagg cccctcaact ggcctgattc
     6541 cggaaggcgt cgatccggat cagaccgagg ccacgagcgg gaccgaaggt aaaggattcg
     6601 ggcgcgtcca gcatgcggaa cggcgtcggc cgcctgacgg gccacaggtt tgaaagacgc
     6661 cgatcactcg ttggtgagtt tctccggctc cggtgcgcac tccgggcaaa actcaagagc
     6721 ggtacgggcg ggtgccgccc ggactggaca cctgtggctg ggggatggcg tggagagaac
     6781 ggcacacaca cacgagggcg tcggcggacc gggcgaacag gcggtgctgc tggctgcggg
     6841 gctcgcggac ctggccgtca ccacggtggg gtcagccctc acctccgtac gcgggctgct
     6901 gcggcggtcc gacacggccg agctggcggc cgaggccgag caggacctga tcgcgcgcgg
     6961 ccggctcgca ctcggccggt acacgagcac gcccccggcg cacctggagg tgctcgcccg
     7021 ccatgtgatc gcccagcgcg acggtgaccg tgcctgaggc gtgggaaccc agcgcgttca
     7081 aggcccgggt ggaccaggtg ctgcaccgct tcgcctccga ggaggccgag caactcatcg
     7141 cggtcgacgc ctccctgagc cccgtggcgg aggcggtgga gacggccgtg gccgacggca
     7201 aacggctgcg ggcggccttc tgctactggg gctggcgcgc cgccgggcag cccgacagcg
     7261 acgcgctggt gcgggcggcg gcctcgatgg agctggtgca cgcggcggcc gtcgtccacg
     7321 acgacctgat cgacgacagc ccgctgcggc acgggaagcc caccgcgcac ctggcgctgc
     7381 gcgaggcggt gaagggccac ccggaacccg ctccggcggc gaggtcgttg gcgatgctcg
     7441 ccggggacct gctgatatcg atggccggac agctcttcgt caccagcggc ctgcccgccg
     7501 cctacgtctc ccgggcacgc cctctctggg cctgcctggc acgcgagttg gttgcgggcg
     7561 agtgcctgga gatcctgcac accgggggcg ccgaccccga cacggcggtc tcgctcaagg
     7621 tcgtccgcta caagaccgcc aagtacaccg tggagcagcc cttgttgatc ggagcactac
     7681 tgggcggggc cggggagcgg ctgcgcgcgg gctgctcggc gtacggactg ccgctgggtg
     7741 aggccttcca gctgcgggac gacctcctgg gccttttcgg ggaccccgcc ctcaccggca
     7801 aggacggctc cgacgacgtg cgcggccatc ggccgaccgc cctgctcgcg gagacctggc
     7861 ggctggccgg ggaggaggac cgcgcccgcc tccgcgcctt gctcgccccc gctaccggga
     7921 cctgcacagc cggcacgacc gacgccgtgc gcgacgtgat gcgccggctg aaggcccccg
     7981 accgcatcga ggccatgatc aacgcccggg tcgaggaggc gctgagtgcc ctcgacgagc
     8041 tggacctgcc cggccccggt gccaccgcac tcgccggcct ggcgcactcg gcgtccgtcc
     8101 gccgtcactg acgcctcccc gaggcccccg gaaaggcaag gctctccatg acttccgccc
     8161 ccgccccgaa ctacaccaag gcatcactgg acgcgctgcg acagagcggc gacgagctcg
     8221 ccgacgccac ggtcgccgcc ctcttcgaac gcggtgaggt cggcacgttc aacaccctga
     8281 tgcgctatgt ctccaccgcc ggagccccgc ttcccgacgg cctgccggac gtggcccggg
     8341 agtacctcga cgccacagcc gcgccgcccc cctgggtgga ctgggacgag atggagaagg
     8401 ccaggctgtt cttcatcgac aacaacgtgc acatctccac cgccctctcg ttcgcctcca
     8461 tgcccgcctg ttacgtcgtc ccgcacgtgg cgaagctgct ctcggcgacg cacgggctga
     8521 actacccgtc caaacggatg gcggagaccg gccagttcac cgtctatctg atgcgacccg
     8581 acgccttcga ggcgggcagc cgcttcgtcc cggccgcgca gaaggtccgc ctcctgcacg
     8641 cctccatccg tcaccacctg cggcgcgagg gcgtctggga cgcggagagc cagggggtgc
     8701 cgatctgcca ggaggacatg atcggcggcc agatgttctt ctcgatgctg gtcctggaca
     8761 gcctgcaccg gctcggcatc catatgtccg aggagggcgc ggaggcctac tactacgcgt
     8821 ggcgggtggt cggcgcgatg ctgggcgtcg accagcaggc cgtacccaag tccctcgccg
     8881 aagcgcggga gttcctcgac ctctacatga tccggcacat gggcccgtcc cccgagggcg
     8941 cgctgctgac ccggcagctc atcgacctct acgaggaggt cgtccccggc accttcttcg
     9001 acccgatcgt ctccgccctc atccgccacc tcgtcggcga cacctgcgcg gactggctgg
     9061 aggtgccccg taccccctgg gacaccgtcg ccaaggccgt cccgcacctc ctcggcgtcc
     9121 tggagaccat cgaggaccgc tccccgctcg gcgcctgggc cctggaccgg atcggccacc
     9181 tcaccacggt cctggagctg tcctccctca cccggggccg cgtcatgcac tacgcgatcc
     9241 ccgaacacct gaagaaggag tacggcgtcc cgtccgggcc cgcccgcacc ggccgctgga
     9301 gccctccggc ggcgacggtg ccgggacctc ggtagggaag ggctcaactg ccctctgaac
     9361 ggttcagcgc cgagaacgtc gtgccggtcc gcaccgccgc gctcggcgtc ctcgcctcga
     9421 tcgaggtgct ccggtcaggc ggccgtaccc cgaaggaccg aggctctgcg gcccgtagcc
     9481 cgcgtatgcg ggagagcggc ggcggacaac gggtcatccc cgtcgtccgc cgccgcgatg
     9541 tcgcccgccc gttcccggga gccgtcccta caggaacgag ttgatctcga tcgtctcggt
     9601 ccggccgggg ccgacgccga tcgcggagat cggtgcgccc gacatctcct ccagggcctt
     9661 cacgtaaccc tgcgcgttct tcggcaggtc ggagaaggtc ttggccttgg tgatgtcctc
     9721 ggaccagccc gggaggttct cgtagatcgg cttcgcgtgg tggaagtcgg tctggttgta
     9781 cgggagttcc tcgacgcgct tgccgtcgat ctcgtacgcc acgcagaccg ggatctgctc
     9841 ccagccggtg agcacgtcga gcttggtgag gaagaagtcg gtcaggccgt tgacccgggt
     9901 cgcgtaccgt gcgatcgggg cgtcgaacca gccgcagcgg cggtcacggc cggtggtgac
     9961 accgcgctcg ccgccgatgc gccgcagcgc ctcgccgtcc tcgtcgtgca gctcggtcgg
    10021 gaatggaccg gcgccgaccc gcgtcgtata ggccttgagg atgccgatga cgcggctgat
    10081 cttcgtcggg ccgacaccgg cgccggtgca ggcgccgccc gccgtcgggt tcgacgaggt
    10141 gacgaagggg tacgtgccgt ggtcgacgtc gagcagggtg ccctggccgc cctcgaagag
    10201 cacgaccttg ccctcgtcga tggcatcgtt caggatcagg gtcgtgtcgg cgacgaacgg
    10261 cttgatctgc tccgcgtact ggagcatgtc ctcgacgacc ttgccggcct cgatggcccg
    10321 gcggttgaag accttggcca ggagctggtt cttctgctcc agggccgcct ccaccttctg
    10381 ctccaggatc gactcgtcgt agaggtcctg gacgcggatc cccacccggt tgatcttgtc
    10441 ggcgtacgtc ggaccgatgc cccggcccgt cgtgccgatc ttgcgcttcc cgaggaagcg
    10501 ctcggtcacc ttgtcgagcg tgacgttgta cggagtgatc aaatgagcgt tgccgctgat
    10561 cagaagcttg gacgtgtcga cgcctcgctc gttcagaccg ctcagctcgg agagcaggac
    10621 cgccgggtcg accacgacac cgttcccgat gaccggggta caacccggcg acaggattcc
    10681 ggaggggagg agatgcagtg cgtacttctg gtcgcctacg acgaccgtgt gaccggcgtt
    10741 gttaccgcct tggtatcgca cgacatagtc cacggatcca ccgaggaggt cggtggcctt
    10801 ccccttgccc tcgtcacccc actgagcacc gagcagcaca agtgcgggca caggcgtaca
    10861 ccccttccgg gcggggcatg tccaaggtca gggggcgtac gtaaaggtcg tacctgccgc
    10921 acgacgatgt acggcaaagc ctgagccgtc gaaccgggtg ccccggaata gacgaagccc
    10981 ctggcgcaat agcgcaaggg gctcttgcac caagatgcta cccgaggaag gaccgaggtg
    11041 tcggctgcag agccccccgg cgacggcgac gaccagctcc tggtggtcat cgacccggtc
    11101 gcccgccgga ccgacggcga gtccgtgcgc atcgccaagg acgtgctgag cgccggctcg
    11161 cacgccaaga tctgccttcc ggacaccccc gaggagttcg cccgggccct gtcccggcgg
    11221 ggtgcgcggc ggcccgtggt ggtcggcgac gatcatgcgc tgctgcgcgc ggtggcccag
    11281 ctgcaccgcg aacgggagct ggccgacggc gtcctctccc tgatccccgt cggcgcggcg
    11341 cacgccctgg aggtggccca cgccctcggc gtcccccggg gcgcggtggc ggccgcccgg
    11401 accgcgctgg acggtgcggt gcggcggctg gacctcctgg tcgacgacag cgacggcgtg
    11461 gtcctcggcc gcctgcgcat ccccgccccg ccgcccccgc cgcccggctc cgggaccccg
    11521 cacgcgggcg tcacggccgt ctgggacacc tgccgctcgc tggtgagctc cctggtccgc
    11581 ccggccccgg tcgccgccac gacgaacccg ggcacgcacc gcctgcgcat cgaggcggac
    11641 ggggtgctgc tgagcgacct ggacacgccc gtccgggacc tctcggtcac ctcccagggc
    11701 gacgggggcc tggccgacgt cgtcgtccgc accggttccg gcgaggacgt gacggcggag
    11761 gccaaggccg tcacggtctc cggcgcggac ttccgctacc gggcggacat acagaccggg
    11821 gggccggtgc ggacccggac ctggacggtc cgggcgggcg cctgggggct gatgctgccg
    11881 ggcccggcga gcgcggacgc ggcggcgggc gcacgctggt agaagacgcc cggaacgtcc
    11941 cggaggtgtt cgtcatgacc aggatcgctg tcggatggca catcgacctc gaattcgagg
    12001 aggacaccca ccgcacccgc gcggcggcgc tcgtccgcct ctccgacgga acagaggtac
    12061 gcgcccacgg ctacgccagc cgccacccct cggacgccga ccagcagcgg gtcggggagg
    12121 agatcgcggg ggccagggcg ttgaacgaac tggcgatgaa actgctgacc aaggcccacg
    12181 acgagatcga cgaggcatcg ggccggaagt cgtacccgct gacgtgacac cggggctccg
    12241 ccccggacgc cggaggggct tgaacgcgcc ctggaaccgc tcccgtgccc cgtcgcgtcc
    12301 cccggatcat ggaaaccgag aacccgcggc gtgaagccgt cgtcggcacc gccggctgcg
    12361 tgaccgcctt cgccggagcg ctcgcgggca tcgtgctctg ggcgccgcac ggcaagggcg
    12421 gtctcctcga cggcttcgag ggcgcctcca actggaacgt gctctgggtc ggtctgcccc
    12481 tcatgatcct cggcgggacc gcggcggccc tggccgtgtt cttcctggtc cggggcgact
    12541 ggaagcgggc gctcggtctc ctcgcggcca tcgccgtcct cttcgcgctc ggcgtcgccg
    12601 tggacgcgct ggccggggcg ccgaggccgg agtgctacga cccctgctga gcccgcgcgc
    12661 gcccggccga cggacctaca cctccgcccg cagctccttc accccccgga tcacataccc
    12721 cgggtgccac tcgggctccg ccgtcatccg cagcgcgggc gccttccgca gcagctcccc
    12781 gaaggacgcg gccagctcca gccgggccag tggggcgccc aggcagaagt ggatgccggc
    12841 gccgaaggtg acgtgcgggt tgtccgtccg ggacaggtcc agcgtgtccg ggcgcgcgaa
    12901 ccgctccggg tcccggttgg ccgagccgaa cagcagcgcc acctccgcgc cccgcccgat
    12961 cacctggccg tcgatctcga tgtcgtccag cacccagcgc tcgaacatct gcaacggggt
    13021 gtcgtagcgg aggagttcct cgatcgcggt gggcagcagt ccggggtcgg cgcgcagggc
    13081 ggccagctgt tccgggtggt ggaagagggt gcgccagccg ttgacggtgg tgttcaccgt
    13141 ggcctcgtgg cccgcgttca gcagcagcac gcaggtggag atcatctcct gctcggtcag
    13201 ccgctcgccc tcgtcgtggg cggcgatgag cgccgagatc aggtcctcgc cggggtcggc
    13261 gcgccgctcg gcgatcagcc cgcgcagata cgcggagaag tcgacggagg cgcggacggc
    13321 ggcggccgcc gtctcctccg acgggttcag ctcgaacatt ccacagatcg ccgccgacca
    13381 gggccgcagc aggccccggt ccgcctccgg gacgcccagc atctccgcga tcaccgcgac
    13441 cggcagcggc tccgcgacct cggccagcag gtccccgccg cccttcgcca cgaacgcgtc
    13501 gaccagctcg gccgccagcc gccgtacggt cggggccagg ttctcgaccg tacgcggggt
    13561 gaacgccttg gagatcagcc gccggatccg gggatggtcg ggggcctcca gatcgaggat
    13621 gccctgcccg ttcagcgtgg tgaacggctc gtgcgcggcg ggcggcgggg tgcggccgaa
    13681 ctcctcgtgg ctgaagcggt gcagataggt ccggccgagc cgccggtcgc gcagcagggc
    13741 cgatacgtcg gagtggtgcg ggatcagcca ctgccccgtc ggctcgaacc agtgcgcccg
    13801 gccggcggcg cgcagcgcgg tgtaggcggg gtagggatcg gcgacgaacg cgggcgacca
    13861 gggatcgaag gacacgtgca tgatccgacg ctacccgcgc ccgcgttcgc cgcaaggccc
    13921 ccggcacaac tcccgctacc ccggggtgac cagccgtgcc tcgtacgcga acaccgccgc
    13981 ctgggtccgg tcgcgcagcc ccagcttcac caggatgcgg ctgacgtggg tcttgatcgt
    14041 ggactcggcg acgatcaggt gcgaggcgat ctccgcgttg gagaggccct gcgcgatcag
    14101 gacgagcacc tccgtctcgc gctcggtgag atcgccgatc cgggccaggg cgggcggccg
    14161 cggggtctcc gcgagcttgg agaactcggt gatcagccgc ttggtgaccg tcggggcgag
    14221 cagcgcctcg cccgaggcca ccacccgtac cccgtcggcg agctgccggg cggaggcgtc
    14281 cttgaggagg aagcccgagg ctccggcccg cagcgcctgg tagacgtact cgtcgaggtc
    14341 gaaggtcgtc agcaccagga ccttcgcgtc ggcgtcccgt gcgacgatct cgcgggtcgc
    14401 ctcgatgccg ttcatctccg gcatgcggat gtccatcagg acgacgtccg ggcccagggc
    14461 ggcgacctgg gcgagggcct gctgcccgtc caccgcctcg cccacgacgg tgatccccgg
    14521 catcgcgttg agcaggaccg agaagccctc gcggaccatc atctggtcgt cgacgatcag
    14581 gacccggatg tcggtgtcgc tcatgcccgg ccgtcctgta cgcgttcgat gacgaccgtt
    14641 tcgccgttgc cgtcggccgt ctcccgggac tccggctcct gggacagcgg tacggggagg
    14701 aacacggcga cctcgtatcc gccgtccgcc gtcgtcccgg ccgtcatctc gccgttcagc
    14761 atcgcgaccc gctcccgcat cccggtgatc ccgtgcccgg cccccggcga gggcttcacc
    14821 aggccgcgcg ggggcccgtt gaccacgcgc agcccgagcc cgccgaggac atagccgagc
    14881 tcgaccctgg cggaggagcc cggcgcgtgc cgcaggctgt tgctcagggc ctcctggacg
    14941 atccggtacg ccgacagctc gacgccctgc ggcagctcgc ggacggcccc ggtgatcacc
    15001 ttctccgtct ccaggccggt ctcgcggacg ttgtccagga gcccgtcgag cgcggcgagg
    15061 gtgggctgcg gggcgtccgg ggcctcgtag tcctccgccc gtacgacgcc gaggacgcgg
    15121 cgcagctcgg tgagggcggc gacggcgttc tcccggatgg tgacgaaggc ctgctccagc
    15181 tccggcggcg ggttctcgac ccggtagggg gcggcctcgg cctggatcgc gacgacggac
    15241 atgtggtggg ccaccacgtc gtgcagctcc cgggcgatgg tggtgcgctc ctccagcagg
    15301 gtgcgccggt cgcgctcgac ggcggtgacg gtgcgctgca cggtgacctc gcgctcggcg
    15361 tcgcgccgga tctggaccac ggcgacgacg agcagcgcga aggcggagag tgtggccagc
    15421 ggtgcggtga tcgacgggtc gccgccctcc agcagcatcc cgaacagcag ggtcagcagc
    15481 cacatccagg cggcggtgcg gggccgggtc cgggcggcca cgaccaccag gaccaccagc
    15541 tgcgccccga aggcgctcgg cccccacagc ccctcgctgc ccaggaccgc gcagaagacg
    15601 gtcgccagca tcgacgccca gaacgcggcg accggcctga tgagggtcat cgccaccgcg
    15661 atcgcgggga ccagacccat caggaggcgg aactgccact ccgcgaaccc ggccatcatc
    15721 acgaggaagg cggcgaacag cactagggcg tgcggggtcc agacggcgcc cttgcgcagc
    15781 ccctcgggca gccgccgcat cagccgtccg tcggggttca gcggcggcag gggccggtag
    15841 gcgaacgcct ggcggaagag gtcctcccgc aggccgtcta tcgcccctgc ggctgcccgg
    15901 aactccgggc cactgttctt cgtctgggtc tcggtcacgc ttccacggta ggcggcggcg
    15961 gacggcgggt cgtcaccatc gctgcggatt ccggggcgtc cccctcaagg actacccgcc
    16021 tccgccgtac cgcttaaagg accgaaaatc ccctggtcag cagcgctttc agggctgcac
    16081 gcgaaagtgc ttcgcgtgct cctcggccca ctgcgcgaag gtccgcgccg gccgcccggt
    16141 gaccttctcc accgtgtcca gcacggtccg gccctccggc ggcgtgtccc ggtagacgtc
    16201 gatcaggaac gcgatcacgt cctccggcat gccctggccc cgccagctct ccagcgcctg
    16261 ttcctcggtg agctcgacca gctcgacgtc cgtgccccgg accgcgccga tggccgccgc
    16321 cttgtcgcgg acggtcagca cctgcggtcc ggtgaccagg tactcctggc cgccgtggcc
    16381 gtactcggtg agggccgccg ccgccaccgc cccgatgtcc gactcgtgga ccaccgcgct
    16441 cagccggtcg acgaagggct cgcgcaccac cccctcgctc ctgatgccgg gcgcccactc
    16501 cagggcgttc gccatgaact ccaccggcat cacgacggtc cagtcgaacc cgctcgcccg
    16561 caccgcgctc tccatcgggg tggccccgcc gccgtgcagc acggtcaccc ggcgcacacc
    16621 cgccctgcgg gccaggccga ggatctcctc accggtctcc agcggggcga agaggccgcc
    16681 gccgaaggtg atgaggtgca gtccgctcac cccgtccagc gccggctcca gcgacgcggg
    16741 atgtgtgagg tctccgcgta cgacgtcgac gccggccgga agctccgcgc gcgccgggtc
    16801 gcgggtcagc gcccggacgt gctcgccgcg ctccagcagg tgctcgacca cacggcggcc
    16861 gaccgttccc gttgctccgg tcaccaggat cgtcatgagg ttctccttcg tcggttgcga
    16921 ctccgcccga gcggcacaga accaacgtag agatccttgc ggacaccttc ggtccgcaat
    16981 cgggacggtc cggcggggaa ctcaccaggc gagctgggtg atctcctcgg ccaccacggc
    17041 gcaggcgtcg gcggccgggt cgatcagcgg gaagtgcccg acgccgccga gcagcgtcag
    17101 cccgaccgtc tcgccggacc tggccgccgc gtcgacgtac gcctcggcga cggccttggg
    17161 cacgacgatg tcgtcgacgc cctggacgat cgcggtggcg atcccggtcg gcagcagcac
    17221 cccggggtcg gcgtgcgccg cccgctcctc gaagtcggct ttcgtgccca ggagttgatc
    17281 gaccgcacca ccgcacaccc cgagcccgac cgccgtggcg aagtccgcga tcggggccag
    17341 cgcgacgact ccgcgcagcg gcggcgggac gggcagccgc cacggcgacc cctcgggcag
    17401 gacgtgccgc gcagccgccc acagcgcgag gtgtccgccc gccgagtgcc cggcgaccac
    17461 gatccgccgc acatcggcgc ccggcagctc acgggcggcc agcacgggca tcgcgtccag
    17521 ggccgcggcc acgtcgtcga aggtctccgg ccagcgcccg gcgacgggat cggcgccgcc
    17581 cggccgggcg ttctccgcgc cgtcgcgctg ctgggggatg tcgtcgccgc cgcgccggta
    17641 ctccacgttc gccacggcga agccccggcg ggccaggaag tccgcgagcg gggaggcatg
    17701 ggcccggtcg tacggggccc gccaggcgcc gccgtgcagg aggacgacga gcggggcggc
    17761 ggtgcggccg tcgcgcgggg cgtagaagtc gacgacctgg tcggggtggt caccgtaggc
    17821 ggcggtggcg tcgggggcga cgggcggatg ggcgaacgcc gacgcgctct ccgcctcgtc
    17881 ccgatcacgc gccgcagagt ccgggaaacc cggggaatcc gacatgctgc tcaaccgtcc
    17941 tatgcccgtg gcctgcgcct gtgttctgta cctgtgtcag gtgcccaact gggttgacct
    18001 gcggggacgg taccagcact cggcaccgtc cccgcccggt cgaacacacg gtgacgaccc
    18061 gtcagccgac ggtgttcccg gcgggcacct cggtcagcac ctcggcgagg a
//
