LOCUS       NZ_JALDPQ010000035     23955 bp    DNA     linear   CON 28-MAY-2024
DEFINITION  Streptomyces sp. TRM75563 664, whole genome shotgun sequence.
ACCESSION   NZ_JALDPQ010000035
VERSION     NZ_JALDPQ010000035.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. TRM75563
  ORGANISM  Streptomyces sp. TRM75563
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 93881)
  AUTHORS   Chen,Y.
  TITLE     Streptomyces aheensis sp. nov., isolated from road
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 93881)
  AUTHORS   Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2022) College of Life Science, Tarim University,
            Hongqiao, Alar 843300, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 14-MAR-2022
            Assembly Method                   :: ABySS v. V2.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022748615.1-RS_2024_05_28
            Annotation Date                   :: 05/28/2024 05:18:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,476
            CDSs (total)                      :: 7,413
            Genes (coding)                    :: 7,165
            CDSs (with protein)               :: 7,165
            Genes (RNA)                       :: 63
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 249
            CDSs (without protein)            :: 248
            Pseudo Genes (ambiguous residues) :: 1 of 249
            Pseudo Genes (frameshifted)       :: 108 of 249
            Pseudo Genes (incomplete)         :: 202 of 249
            Pseudo Genes (internal stop)      :: 19 of 249
            Pseudo Genes (multiple problems)  :: 75 of 249
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:22:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 69926
            Orig. end                         :: 93881
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JALDPQ010000035.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23955
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23955
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23955
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:18317]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18317
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(<295..>857)
                     /locus_tag="MQC87_RS01220"
                     /old_locus_tag="MQC87_01220"
                     /pseudo=""
     CDS             complement(<295..857)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735775.1"
                     /locus_tag="MQC87_RS01220"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="MQC87_01220"
                     /product="IS630 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPTVLGKPFTRWSIRKLADHLSGNITRPVRIGRETVRCLLARRGI
                     SISARKPGRCPRIRTSTPSSPGSSTRSTSGPTAPSPSTSSVRSVSDRPPDPAGPWKTAP
                     TDCRRPTAAPTESPTSTAATPSATTSSGASTASARASTTPGPPCGRSVLPALTAPRST"
     misc_feature    complement(818..833)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.99"
                     /tool="antismash"
     gene            complement(1693..2595)
                     /locus_tag="MQC87_RS01225"
                     /old_locus_tag="MQC87_01225"
     CDS             complement(1693..2595)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MQC87_RS01225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MQC87_01225"
                     /product="hypothetical protein"
                     /protein_id="WP_242735414.1"
                     /transl_table=11
                     /translation="MRILKRVRVVAAALGVVAGTLMASAGPGTSVSQAATPADGAAAAA
                     SRIYGVEIVKQGGVVGDLQTQSVRCPQRKVPIGGGAETSFGHTPWGHEIQLVSSVPLIE
                     GGQPVGWRASAHKAVSPDMTLTTYAVCAYPPSGYQLVQSPVTPSPYDTLTTLSCPAGKV
                     ALGGGGEAIGSGSWLSKSYPTPVSGTAQPTQWALGTAGWDTTTAVVHAVCTDPVYALTV
                     THYNTASESPYGGLLKCPAGTVVAGGGASANGPSASLFSSRPAKAAESGSRDGWWAQGS
                     DNLQSSNIDLYVMCTEPIN"
     gene            <2917..3481
                     /locus_tag="MQC87_RS01230"
                     /old_locus_tag="MQC87_01230"
                     /pseudo=""
     CDS             <2917..3481
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058979.1"
                     /locus_tag="MQC87_RS01230"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="MQC87_01230"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="LTKRARRLEDPTLVVLDTQSVHAAAGVPARHDRPGRGEEGAGTQT
                     ATGRGRAGPGHRRHRPGREQPRQRSRHRPAGPGRRAHRRHRPQSPR"
     misc_feature    complement(3536..3550)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     gene            3771..3905
                     /locus_tag="MQC87_RS37385"
     CDS             3771..3905
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MQC87_RS37385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_278191869.1"
                     /transl_table=11
                     /translation="MLPKNIECTRAKLKRLVRLGVLTEVDVGSFTRTQQATEHRDQQL"
     gene            complement(3959..4138)
                     /locus_tag="MQC87_RS01235"
                     /old_locus_tag="MQC87_01235"
     CDS             complement(3959..4138)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MQC87_RS01235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MQC87_01235"
                     /product="hypothetical protein"
                     /protein_id="WP_242735418.1"
                     /transl_table=11
                     /translation="MLQPDGKTLIAPEGEHYTDTYRRTLGVIEQRFDLSLSPAYLKEAR
                     LPAYAVRGTPYMHI"
     gene            complement(4170..4586)
                     /locus_tag="MQC87_RS01240"
                     /old_locus_tag="MQC87_01240"
     CDS             complement(4170..4586)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MQC87_RS01240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MQC87_01240"
                     /product="hypothetical protein"
                     /protein_id="WP_242735421.1"
                     /transl_table=11
                     /translation="MRDGIRWLVDLEHWMSSVLFARGISAQELAVRMGGDRDGATEPIT
                     DAEAWDLGQWYRPGEEGDGVVRVGEHEGWSFALEYGYSTGGDRLAEISREGVEALHYVP
                     MQEHPPATVFYARNGVKLCGFWAGRGSVALGSGA"
     gene            complement(4888..5835)
                     /locus_tag="MQC87_RS01245"
                     /old_locus_tag="MQC87_01245"
     CDS             complement(4888..5835)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537541.1"
                     /locus_tag="MQC87_RS01245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01245"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_242735424.1"
                     /transl_table=11
                     /translation="MSNFTLHELQCFNAVVRGGGFQAAADLLHRSHPSVFAAVAKLERQ
                     LGLDLLDRSGYRVQLTEVGHAFHRKVRVLLHDAEELQTYAVQLAMGEESELRVVLGDLC
                     PLPPVLEILSSFFAQCPQTRLHLLFETVTGPWERLLEDEADLIVHRVPKSDVRMEWIDL
                     GRVALVPVVAPGFLPFPPDTDITPQRMQALTQCVVRDSSRHPSEQGHFLVEGAPQTSVP
                     DHLMKKELIMHGMAWGHVPRFMIETELCNGSLLSIAGQHFPGVVEELSAARRRDRPHGP
                     VADQLWDFLARHAPVLKPTLGHVPGAKKAPERDR"
     misc_feature    complement(5865..5878)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.06"
                     /tool="antismash"
     misc_feature    complement(5868..5881)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.26"
                     /tool="antismash"
     gene            5934..6746
                     /gene="pcaD"
                     /locus_tag="MQC87_RS01250"
                     /old_locus_tag="MQC87_01250"
     CDS             5934..6746
                     /EC_number="3.1.1.24"
                     /GO_function="GO:0047570 - 3-oxoadipate enol-lactonase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042952 - beta-ketoadipate pathway
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (27-252). E-value:
                     2.2e-31. Score: 101.2. Matches aSDomain:
                     nrpspksdomains_MQC87_RS01250_Abhydrolase_1.1"
                     /codon_start=1
                     /gene="pcaD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537540.1"
                     /locus_tag="MQC87_RS01250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01250"
                     /product="3-oxoadipate enol-lactonase"
                     /protein_id="WP_242735427.1"
                     /sec_met_domain="PF00561 (E-value: 1.3e-25, bitscore: 82.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.7e-15, bitscore:
                     48.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARTRTAITTGDGVRIAYRFDGNEDNPVLLLSNSIGTDLRMWDG
                     QVPALTEHFRLLRYDARGHGASDAPSGPYSMDRLGRDVVELLDALGLRRVHVLGLSLGG
                     MVAQWLGIHVPERVDRLVLSNTAAYLGPANQWDRPIAELLEAPDMQVIAERFLNNWFPA
                     RMLRGDNEVVEGFRRTLLATRREGVAGSWAAVRDYDLRRTATLIQNPTLVIAGEHDTVT
                     SADHGKELAATVPGARFTVLPTVHMANVEGQTKFLEAVVAFLTEGSYL"
     aSDomain        6015..6689
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MQC87_RS01250_Abhydrolase_1.1"
                     /evalue="2.20E-31"
                     /label="MQC87_RS01250_Abhydrolase_1.1"
                     /locus_tag="MQC87_RS01250"
                     /protein_end="252"
                     /protein_start="27"
                     /score="101.2"
                     /tool="antismash"
                     /translation="PVLLLSNSIGTDLRMWDGQVPALTEHFRLLRYDARGHGASDAPSG
                     PYSMDRLGRDVVELLDALGLRRVHVLGLSLGGMVAQWLGIHVPERVDRLVLSNTAAYLG
                     PANQWDRPIAELLEAPDMQVIAERFLNNWFPARMLRGDNEVVEGFRRTLLATRREGVAG
                     SWAAVRDYDLRRTATLIQNPTLVIAGEHDTVTSADHGKELAATVPGARFTVLPTVHMAN
                     VEG"
     CDS_motif       6216..6257
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MQC87_RS01250_0001"
                     /evalue="2.30E-03"
                     /label="NRPS-te1"
                     /locus_tag="MQC87_RS01250"
                     /protein_end="108"
                     /protein_start="94"
                     /score="10.6"
                     /tool="antismash"
                     /translation="VHVLGLSLGGMVAQ"
     gene            complement(7658..8416)
                     /locus_tag="MQC87_RS01255"
                     /old_locus_tag="MQC87_01255"
     CDS             complement(7658..8416)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999240.1"
                     /locus_tag="MQC87_RS01255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01255"
                     /product="hypothetical protein"
                     /protein_id="WP_242735429.1"
                     /transl_table=11
                     /translation="MQKTALVPYAHLPRAHQARHVLTSTVDVFGTAHWLLADRAPQPGG
                     DALPFDALVVAASRARRYEDADQVQVFDAGGREASSFSVGDAIEHLLVDEAGHIWVGHF
                     DENPAGIRRWSPQGHIYWTSDGANIPGLFDCYALNVSGTTAWACTYTDFPLVEIRPDRP
                     ARVWLNQVRGAKAVAVHGERVALYGGYGEEVDRLTRGELTEASVEPTDVGLLTLPDGHL
                     PGRRRAVSRGSRIYVQAEPFTAWGVVDLSS"
     gene            <8617..>9118
                     /locus_tag="MQC87_RS01260"
                     /old_locus_tag="MQC87_01260"
                     /pseudo=""
     CDS             8617..>9118
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005485038.1"
                     /locus_tag="MQC87_RS01260"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="MQC87_01260"
                     /product="DNA polymerase III subunit alpha"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAGEGLVVLLGPASEPLRARARR"
     gene            complement(9295..9534)
                     /locus_tag="MQC87_RS01265"
                     /old_locus_tag="MQC87_01265"
     CDS             complement(9295..9534)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019766100.1"
                     /locus_tag="MQC87_RS01265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01265"
                     /product="hypothetical protein"
                     /protein_id="WP_069753380.1"
                     /transl_table=11
                     /translation="MMRRIAITLAAVAAAGFVAAGPAAAHGTNGWDGPAGGGHAEIEGG
                     WASGEYRNLGGPYGITYIKGQKAYFDAERGYFVR"
     gene            10001..11200
                     /locus_tag="MQC87_RS01270"
                     /old_locus_tag="MQC87_01270"
     CDS             10001..11200
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007456517.1"
                     /locus_tag="MQC87_RS01270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01270"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_242735432.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.2e-53, bitscore:
                     172.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRHHCHSSEDAQVVDSDVVDAVLRTARAVLADRVDEALRSDVLF
                     CEELARRVADFTLEGGKRTRPRLLWWGMRSCGAAETAAALRLGVALELIQSCALIHDDV
                     MDRSRLRRGKPAVHIGLAERAGLSPDSERGSVFGTSAAVLAGDLALAWADDTVAETVLS
                     AVQRRRIGALWRAMRTEMVAGQYLDLRGQVSGESSVAQALRTACLKSASYSVERPLALG
                     AALAGADERTTDALRSAGRCAGIAFQLRDDLLGVFGDPGLTGKPSGDDIREGKPTYLLA
                     VARRWAEAAGDEQALALLGRVTGTADLTEEDLADVRGVLEVTGVRAHVERKAERLHDYA
                     VRRLGQAVDVDAHGGRQLLDLLRTVSGERSGHSPTAGETRSGAADVYSVLIAAEGGSAG
                     "
     misc_feature    10115..10117
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11197..12720
                     /locus_tag="MQC87_RS01275"
                     /old_locus_tag="MQC87_01275"
     CDS             11197..12720
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007456520.1"
                     /locus_tag="MQC87_RS01275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01275"
                     /product="phytoene desaturase"
                     /protein_id="WP_242735434.1"
                     /sec_met_domain="DAO (E-value: 4e-18, bitscore: 58.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITVMGPVDHVVVVGAGLAGLAAALHLLGAGRRVTVVEREGVPGG
                     RAGFLESGGFRIDTGPTVLTMPDLVEEAFAAVGERMTDRLELIRLAPAYRARFADGSQL
                     DVHTDGAAMEAAVEEFAGARQAVGYRRLRIWLERLYRVQMHRFIDTNFDSPLQLAHPDL
                     VRLAALGGFGRLDARIGHFVSDERLRRVFSFQALYAGVPPARALAAYAVIAYMDTVAGV
                     YFPRGGMHALPRAMADAAVDAGASLRYGQSVTRLERSGDRVTAVVTDQERIPCDAVVLT
                     PDLPISYRLLGRSPHRPLPLRHSPSAVILHAGTDRTWPELAHHTISFGAAWKRTFHELT
                     RTGKLMSDPSLLITRPTASDASLAPPGRHLHYVLAPCPNTEVGPGVREWRELGPRYRDE
                     LLAELERREMPGLGAAIEEEGLVTPADWTAQGHAAGTPFSVAHTFPQTGPFRPRNLVRG
                     TVNAVLAGCGTTPGVGVPTVLISGKLAAERITGPRAARTPRPARRGFSA"
     gene            12717..13745
                     /locus_tag="MQC87_RS01280"
                     /old_locus_tag="MQC87_01280"
     CDS             12717..13745
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971150.1"
                     /locus_tag="MQC87_RS01280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01280"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_242735436.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.8e-116,
                     bitscore: 380.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 7.7e-72,
                     bitscore: 234.3, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVHELDAAGIHDPALRAAYTRCRALNARHGKTYFLATRLLSADR
                     RPAVHALYGFARRADDIVDDLGSTATPGDRARALLALEAQLETGRRGARAAEPVIRALA
                     DTAGRYNIDHRHFTDFLSSMRSDLTVGGYASYEELGRYMHGSAAVIGLQMLPVLGTVVA
                     REEAAPHAAALGVAFQLTNFLRDVGEDLDRGRLYLPAELLAAHGADRERFEWSRSTGMP
                     DARITDVLRAAAAHNRTVYRAALPGIAMLAPVSRPCIRTAFVLYSGILDAIEADGYAVL
                     HRRAVVPRRRRAAVALDGLVRAVAARRVRRGRADTVAAVRSDGASRPRTAGAPAPVREE
                     AV"
     gene            13742..14758
                     /locus_tag="MQC87_RS01285"
                     /old_locus_tag="MQC87_01285"
     CDS             13742..14758
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007456523.1"
                     /locus_tag="MQC87_RS01285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01285"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_242735438.1"
                     /transl_table=11
                     /translation="MSPAAGRPRSRRIPLRVRRAPVPWERQAPTWHEAKPGLITEALKR
                     AQSRPSGNWYVIGASRDLPPGKALGVTVGSTEVVAWRDRGGKLRTGPGACPHLGAPLCD
                     SPVRCGTLVCHWHGLVLDGEPFAGWEPYPAFDDGVLLWVRLDRMGGEPPSARPYVPARP
                     RARDAVEAVYSGVGRCEPEDVVANRLDPWHGAWFHPYSFVDLTVTGTPADSPADDAGFT
                     VDVSFKVAGRLVVPVRARFTAPEPRTVVMHIVEGEGAGSVVETHATPIAPDERGKPRTA
                     VTEALVAASDRRGFAVARAAAPLMRPLMRASAGRLWRDDLAYAERRWELRDSGTFPG"
     gene            complement(14798..16351)
                     /locus_tag="MQC87_RS01290"
                     /old_locus_tag="MQC87_01290"
     CDS             complement(14798..16351)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956452.1"
                     /locus_tag="MQC87_RS01290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01290"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_242735468.1"
                     /sec_met_domain="DAO (E-value: 4.2e-13, bitscore: 41.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFLRDSGRGHRRGRDRQAAVVPAPAGRARFTGHAPAVAVVGGGIA
                     GIAAATLLAERGARVTLHEREPGLGGRLSGWPTELADGTTVTMSRGFHAFFRQYYNLRG
                     LLRRVDPDLGSLTRLPDYPLWHDSGLRDSFARVPRTPPLSAMGFVALSPTFGLGDLTRM
                     NPRAALGLLDVRVPEVYERLDGISATDFLHRIRFPEAAHHLAFEVFSRSFFADPRELSA
                     AELALMFHIYFLGSSEGLLFDVPGEPFPTALWEPLHRYLEVHGADVRTQTPVRQVRPLP
                     NGGLDLTTDDRTIQYDALVLALDSGALRRLVAASPELGDTDWRARIARLRTAPPFLVSR
                     LWLDRPVAYDRPGFLGTSGYGPLDNVSVLDRWEGEAARWARRTRGSVVELHAYAVAPDC
                     DRSAVQDETLRQLHRIYPETRSARILDERHEWRADCPMFPVGGYRDRPGVRSLDPTVTV
                     AGDMVRTDLPVALMERAATSGFLAANALLERWGVRGQTLWTVPRGGRSAVLRRLAALAD
                     "
     gene            complement(16351..17079)
                     /locus_tag="MQC87_RS01295"
                     /old_locus_tag="MQC87_01295"
     CDS             complement(16351..17079)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382247.1"
                     /locus_tag="MQC87_RS01295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01295"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_242735441.1"
                     /transl_table=11
                     /translation="MTLLRGDALSEAFDHGSAAYDRLVSASPGYHAHLRRSARRLGLPE
                     GGRGLRVLDLGCGTGASTAALLAAAPRARITGVDASAGMLDRATAKSWPQSVDFAHHPV
                     EELAGRLEAGSFDAVFAGYLFRNLTDPDVALDMVRGLLVPGGRLAVHEYALGGSPVHRA
                     LWNAVCSLIIQPAGRLAGDADLYRHLRVSVTRFDTAPAFAQRLRRAGFADVRILPLPSW
                     QSGITHTFVGRTTAGAGVQA"
     gene            complement(17076..18317)
                     /locus_tag="MQC87_RS01300"
                     /old_locus_tag="MQC87_01300"
     CDS             complement(17076..18317)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382246.1"
                     /locus_tag="MQC87_RS01300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01300"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_242735444.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 2.6e-110,
                     bitscore: 361.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADFDVVIVGAGAAGLSLAYDLCAQGSAVPLSVALIDAPSGPLR
                     APPRTWCFWEPPGGPYDQSLAHSWPRLRFRAADGASTVVKLSRLHYKMLRSDAFEALVE
                     QRLSRAPALRRMEATASAVRDVPSGAGGEVLTQVACGERVLVRGRRVFDSRPPYHLPPA
                     RTTLFQHFTGWFVRTERPVFDPETADLMDFRTAQPARGLSFGYVLPLVPHTALVEYTEF
                     SPAPLDADGYRRALRHYTHDVLRLGPFEVTAQEHGVIPMTDGRFPRRQGRSVYRIGTAG
                     GATRPSTGYTFAAVQRQSRAIADQLRSGRPLRMPVPYGRRARMMDAVMLRALDSGRVNG
                     ADFFSRLFRGVPGERLLSFMDGSSQLHEDLLIGLRTPMAPMLRTVFELPFRIRRESPAA
                     PLPPSPPAHEESTP"
     misc_feature    complement(18222..18224)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18758..18913)
                     /locus_tag="MQC87_RS01305"
                     /old_locus_tag="MQC87_01305"
     CDS             complement(18758..18913)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015613097.1"
                     /locus_tag="MQC87_RS01305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01305"
                     /product="DUF6131 family protein"
                     /protein_id="WP_242735470.1"
                     /transl_table=11
                     /translation="MIILGLILLIIGLIAGIGVLWTIGIILVAIGAVLWALGALGHAVG
                     GRRHYW"
     misc_feature    complement(18881..18895)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.43"
                     /tool="antismash"
     misc_feature    19209..19225
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 24.59"
                     /tool="antismash"
     misc_feature    complement(19228..19241)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.87"
                     /tool="antismash"
     misc_feature    19228..19242
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.87"
                     /tool="antismash"
     gene            19254..19595
                     /locus_tag="MQC87_RS01310"
                     /old_locus_tag="MQC87_01310"
     CDS             19254..19595
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126855.1"
                     /locus_tag="MQC87_RS01310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01310"
                     /product="hypothetical protein"
                     /protein_id="WP_242735446.1"
                     /transl_table=11
                     /translation="MSPRTYHHPDTDEIAIPRVLFALSEPLRLNMVRMLAKQGETDSID
                     LGPELPRSTLTHHTSLLRESGVVFVRAEGRKCMIRLREDDLEARFPGLLGTVLTGYENA
                     DDDRGEGDA"
     gene            19592..20776
                     /locus_tag="MQC87_RS01315"
                     /old_locus_tag="MQC87_01315"
     CDS             19592..20776
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007460493.1"
                     /locus_tag="MQC87_RS01315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01315"
                     /product="MFS transporter"
                     /protein_id="WP_242735449.1"
                     /transl_table=11
                     /translation="MIRKVWPLALAAVSLGIDAYVLAGVLPRIADSLTTTVSMTGLGVT
                     TFTAAYAVAGPLLSGRLTRGSTARALLIALGLFNLGNLVTTIAPGIEVFLASRVMAGVG
                     AGILTAVATATAAAMVADHERGRAMSLVTFGLSAGTVAGVPVGMIIGQSAGWRWTMALV
                     VLIGVASMAALAFRGKTLPRLDAAAGGSAFTVLRSSRTSVGIVAAFLLGVASLGLYTYL
                     LPMAEDRGLGGLGFALVWAWGIGGVTGSALIGKPLDRYGPKPLLVTLPALLALSFAAVW
                     LSSSPIVWLIAAAVWGAAGWASVPTLQQALTAHRPAQAMSIIAFQMAAMYLGSAVGAAL
                     GGALLTSGDGPADLAAWALAPAVLAVALTSWIATGAPTRLAPERAQTAACESTA"
     gene            21035..21970
                     /locus_tag="MQC87_RS01320"
                     /old_locus_tag="MQC87_01320"
     CDS             21035..21970
                     /GO_function="GO:0045027 - DNA end binding [Evidence IEA]"
                     /GO_process="GO:0006303 - double-strand break repair via
                     nonhomologous end joining [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014046231.1"
                     /locus_tag="MQC87_RS01320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01320"
                     /product="Ku protein"
                     /protein_id="WP_242735451.1"
                     /transl_table=11
                     /translation="MPRPLWTGAISFGLVTIPVKVVSATEDHDVHFHRVHLEDMGRVRT
                     RKVCELDGEVVTQDEIGKGYEIAKDQTVPVTDEELEQMPLPTAKAIEIAAFVDAGTIDP
                     VRISDSYYLAADGQVAAKPYTLLRRALERSSKVAVAKFAWHGRERLGLLRIREGAIVLH
                     SMKWPDEVRSPDELAPREVEVGEEEIEQALQLAERMTIEDLSGFRDEYREALEDIIAAK
                     SEGKPVPAPAEDGKQEKGEVVDLMAALNASVKTAQESRGDRGEGATVHEMRPSKKTSRK
                     TPAKKTAASKKSTASKKPAKKTAAKKRSAS"
     gene            22014..22946
                     /gene="ligD"
                     /locus_tag="MQC87_RS01325"
                     /old_locus_tag="MQC87_01325"
     CDS             22014..22946
                     /GO_function="GO:0003910 - DNA ligase (ATP) activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="ligD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010063844.1"
                     /locus_tag="MQC87_RS01325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01325"
                     /product="non-homologous end-joining DNA ligase"
                     /protein_id="WP_242735453.1"
                     /transl_table=11
                     /translation="MLATPGPLPPTNVEDRWAFEVKQDGQRAMVYLPGDGTIVLRARSG
                     TDITAVYPELLPLAEALGARSAVLDGEVVALDDQDRSDFERLQQRMGLSDSPAKAARMA
                     ARVPAHLMLFDVVHLDGQLLTGLPYAERRELLEGLGLDGPAWSTPAAIVGHGAQAWEVA
                     RDAGLEGLIAKRLTSRYEPGARSKTWLKVKVHRLADVVIGGWVPGRGRLTGLPGAVLVG
                     ERRDGSVHYAGSVGTGWSEAERARLAELLQAAAIDACPFAQIPQVAGARWVLPRLVGEV
                     RYSSRTRAGRLRHPSWHRLRPDLAPEDLA"
     gene            complement(23095..23604)
                     /locus_tag="MQC87_RS01330"
                     /old_locus_tag="MQC87_01330"
     CDS             complement(23095..23604)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (23-141). E-value:
                     7.1e-08. Score: 24.9. Matches aSDomain:
                     nrpspksdomains_MQC87_RS01330_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955915.1"
                     /locus_tag="MQC87_RS01330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01330"
                     /product="SRPBCC family protein"
                     /protein_id="WP_242735455.1"
                     /transl_table=11
                     /translation="MTSTPTGRRVTIDGLDTIAFDRTFRAGIKDVWAAVTEPDRLARWI
                     GEWTGDPSTGAVAFRMLYEGDDHPAELFTIQECQAPRRLVLTSQVPGEELVWHMTLTLV
                     EHEGATTLTFTQSVGDDPAMAGGVGPGWDYYLDRLVAAETGGDPASVDFGDYHPAHAQH
                     YLDMFS"
     aSDomain        complement(23182..23535)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MQC87_RS01330_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="7.10E-08"
                     /label="MQC87_RS01330_Polyketide_cyc2.1"
                     /locus_tag="MQC87_RS01330"
                     /protein_end="141"
                     /protein_start="23"
                     /score="24.9"
                     /tool="antismash"
                     /translation="FRAGIKDVWAAVTEPDRLARWIGEWTGDPSTGAVAFRMLYEGDDH
                     PAELFTIQECQAPRRLVLTSQVPGEELVWHMTLTLVEHEGATTLTFTQSVGDDPAMAGG
                     VGPGWDYYLDRLVA"
     CDS             complement(23601..>23953)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=2
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126737.1"
                     /locus_tag="MQC87_RS01335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MQC87_01335"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_242735457.1"
                     /transl_table=11
                     /translation="DPIRRDLLRALASGPARVVDLAAQHPISRPAVSKHLRLLTEAGLA
                     TVEDHGRERHYALARPGLAPVRALLDELAGRRSPIPESAFDALDLEVRRTVHDRRAGND
                     AAPGTGRPQEESA"
     gene            complement(23601..>23955)
                     /locus_tag="MQC87_RS01335"
                     /old_locus_tag="MQC87_01335"
ORIGIN
        1 gctgccccca cacccgaccc ggtcctgcgg cccgacggac ccgagcgcaa cgacaccgcc
       61 ctgctgctag gagtactgct cgccaaaacc gaactcgccg ccgccctacg ggccgacccc
      121 gcccaggaac ccccgcgcag catgacagac ctgctcaccg gataccgctc gacggtcgcc
      181 tcgcccgggg acacgacccg ccttcggctg ctgagcctcc gcctcgtccg cagcgccgtc
      241 gaagccaccc tcgacgacga cactgacccg ctgctcctcg ccgccgccga cgccgcacag
      301 ctcgacgttg ttgcgagcgg cccacctgcg gattctccag ttcaggtgag ctgagaggtt
      361 gtcgaggatc acgtagatcg gggcgccgtc agggcgggca gcacggatcg tccgcagggc
      421 ggcccaggtg tggtcgatgc ccttgcgctg gcggttgatg ccccagagct ggtcgtcgcc
      481 gacggagtag cagccgtgga agtaggtgat tccgtgggtg cggcggtagg tcgccggcag
      541 tcggtcgggg cggttttcca gggcccagca ggatccggcg gtcggtcgga taccgagcgg
      601 accgaactcg tcgaaggcga aggtgcggtc gggccgctgg ttgatcgcgt actcgatccg
      661 ggcgagcttg gcgtcgaagt ccggatccgg ggacaccttc caggttttcg tgcgctgatg
      721 gagatcccac ggcgggccaa caagcaccgc acggtctccc tgccgatccg gacaggccgg
      781 gtgatgttcc cgctgaggtg atcggcgagc ttacggatgg accagcgggt gaagggcttg
      841 cccagcacag tcggccgctg aacaggggaa acagcggtaa tcagagaatg agggttcaca
      901 cctccggtgc aaccccggcc cacccccggg cgcaaccgtc cagcaccctg tccgggcaac
      961 cgccggcgca accctctacc cggctccgtc tgacttctcg cccactgcgg cgttgagttg
     1021 tcacacgggg cctcaacgtt ggtggcggtt cgaccagacc gtgggaaggg tgggctcgca
     1081 cccgcatgat ccaccggccc tgcacaacca actcacctca ttcgagcgag atcgcacgaa
     1141 ccatgactcg tcacgggaca ccgctgacgc aaatcctgac cgcgcaggtc gcagcccggt
     1201 gggcaagcct cccggcccgt gggcaagacg ggccttgacc ccgaacccct gatcccggag
     1261 cctgacggcg tcgtggacgc ctgaaccgtg cgcgtacgca cgggcggcgc ccgtgccgtg
     1321 atgagggcgg ggcgccgtgg tgtgccgggg aggggcagtg cgggatgcca tcgatgatgt
     1381 cgcgggcacc ctgacgcagc agctcggcgg cgacccggga ttcgagggcc ccgggtcgtt
     1441 ccgcgtctcg ctccacagtc gggcgtgggc gcgtcctcgg cgatcaagtc gtccagccgg
     1501 gaccgggttg ccgtcgacag ctggcccacg gttgccgcgc cgaacccgtt cctcgaaggt
     1561 gctgaccacc ttgcccacca gccgggcgat ctgtcccggg gccggcggct ccagccggtc
     1621 ccggttcagc tccaccccgt acagctcgac cgccagccac tgcgaccgcc tgcgttcagc
     1681 gaagagcggc gcctaattga tgggctcggt gcacatgacg tagaggtcga tgttggagct
     1741 ctgcaggttg tcgctgccct gggcccacca gccgtcgcgc gagccggact cggccgcctt
     1801 ggcggggcgg ctggagaaga ggctggccga aggcccgttg gccgatgcgc ctccaccggc
     1861 gacgacagtc ccggcggggc acttgagcag gccgccgtag gggctttcgg aggcggtgtt
     1921 gtagtgggtg acggtcaggg cgtagacggg gtcggtgcag accgcgtgga ccacggcggt
     1981 ggtcgtatcc catccggcgg tgccgagtgc ccactgggtg ggttgggcgg tgccgctgac
     2041 cggagtgggg tacgacttgc tcagccagga gccagacccg atggcctcac ctcctccgcc
     2101 cagggcgacc ttcccggccg gacacgacaa cgtggtcagc gtgtcgtagg gggacggcgt
     2161 gaccgggctc tgaacgagct ggtatccgct gggcgggtag gcgcagactg cgtaggtcgt
     2221 cagggtcatg tcgggggaga cggccttgtg ggcggatgcc ctccagccga cgggctggcc
     2281 gccctcgatc agcggcacac tgctgacgag ctggatttcg tggccccagg gggtgtggcc
     2341 aaaactggtt tcggcgcctc cgccgatcgg gaccttgcgc tgcgggcagc ggacactctg
     2401 ggtctgcagg tcgccgacca cgccgccctg cttgacgatc tcgacgccgt agatgcgcga
     2461 cgccgcagcg gcggcaccgt ccgcgggcgt cgccgcttgc gagaccgacg tccccgggcc
     2521 ggccgaagcc atcagcgtcc ccgccaccac ccccagggct gccgcaacga cccggaccct
     2581 cttcagaatg cgcatgagac ctctctcgac gaacccgcct gaataacgct cggtaattct
     2641 gacactgctc agcgtggcct gatttcggtg tggtggtact cccgccgact cgaggagagg
     2701 gccgctggcg gtaccgccct ggaaagtgag ggggcagcca ccctccgggg ccagcgcgcc
     2761 tcctggcggc ctgccgccag aagcgacgag atcatccgat caggcgaaca cgattccgcc
     2821 acggaacagg gtttgcccag gattgtgccg gggccttcat tcggcagacg acggcacgct
     2881 ggcggacgtg tcggagtcgt cggcggccgg ccactcctga cgaagcgagc ccgccgacta
     2941 gaggacccga ccctggtggt cctggacacc cagagtgtcc acgcggccgc cggggtcccc
     3001 gcccgccatg accggccggg acgcggcgaa gaaggtgccg ggacgcaaac ggcgactggc
     3061 cgtggacgtg ctgggcctgg tcatcgccgt catcgtcctg gccgcgaaca gccacgacaa
     3121 cgcagccggc atcgccctgc tggaccaggt cgccgagcac accggcggca tcgtccgcaa
     3181 agccctcgtt gaccagggct tcaagacagc cgtggtcgcc cacggcaccg cgctcggcat
     3241 cgacgtggag atcgttgaac gcaacccgca ggagacgagg ttcgtcccac agccgaagcg
     3301 gtggagggtc gagcagacct acagaatcct catattgcac cgacgcctag tccgcgacta
     3361 cgagcaccgc ccggcctcgt cagcctcccg cgtgtactgg gcgatgaccc aggtcatggc
     3421 cggacggctc accggcgcga acacccccac ctggcgcgga ccgctggcgg tggcagcgtg
     3481 aacatcgagc ccctactaga cgcgctgggc ctccaagagg acgccgcccg ggccctggcc
     3541 gacgacctcc gcacccagat cgaagagctg cacggccggc tgcaggaggc ggagactcac
     3601 ctcgaacgcc tcgcgatcac gcggaagacc gtcaccgccc tcgccgaccg gctcccgacc
     3661 gttccgcaga cctgcccgag cacccggact acccccgcat cctcggtgtc ttcaacgagg
     3721 ccgccggccc gctgcgggcc tgtgacgtct gcgaagacct cggccacgaa atgctgccga
     3781 agaacatcga gtgcacccgc gccaagctga aacgcctggt caggctcggt gtcctcaccg
     3841 aggtcgacgt cggcagcttc accaggacgc agcaggccac cgagcaccgc gatcagcagt
     3901 tgtgactgag cgcttcagct gacgagtgaa cacatgggtt ggtggccgcc gcgatcgctc
     3961 agatatgcat gtacggggtg ccgcgaactg catacgccgg caggcgggct tccttcaggt
     4021 aggccgggga gagcgagagg tcgaaccgct gctctatgac gccgagggtg cgccggtagg
     4081 tatccgtgta gtgctcgcct tcgggggcga tgagcgtttt cccgtcgggc tgcagcacgt
     4141 acctgctgac gagctcggga aacagcaggt caggctcccg accccagcgc cacacttcct
     4201 cgcccagccc aaaagccaca cagcttcacg ccgttccgag cgtagaagac cgtggccggc
     4261 gggtgctcct gcatcggcac gtagtggagg gcttcgaccc cttctcggga gatctctgcc
     4321 agacggtccc cgccggtcga gtacccgtac tccagagcga aggaccagcc ttcatgctct
     4381 ccgacccgta cgacaccatc gccttcctcg ccgggtcggt accactggcc gagatcccac
     4441 gcttcggcgt cggtgatcgg ctcggtagcg ccgtcccggt cacctcccat gcgcactgcc
     4501 agttcctgcg cggatatccc gcgtgcgaac agcacgctgg acatccagtg ctccagatcg
     4561 acaagccacc gaatcccgtc gcgcatgcct tcgcctctca cctatagcca ttgatcctcg
     4621 ggtgcaccct atgcagccgc accgacaagg cgatctcatc gtgtagcgcc aagttgatca
     4681 cgctgacggc cgggaagcgc tggagccgcc gtcgccggcg ctcaactggc caaggaaagc
     4741 gctcagcgac agcagcctgt cccaacctca gccgggaatg gacatcagct cacgaaccgc
     4801 cctctcggag ccttagaaca aacatcaggg cgctcaagac atgttgttct ttggttcatg
     4861 gcgcgcatcg gccgagttcc ggcaacgtca cctgtcgcgt tccggcgcct tcttcgctcc
     4921 gggtacatgg cctagcgtcg gcttcaggac cggtgcatgg cgggccaaga agtcccacag
     4981 ctggtcggcg actggcccgt gcggacggtc gcgccgtcgc gctgccgaga gttcctcgac
     5041 cacaccggga aagtgctgtc cggcaatgga aagcaggctt ccattgcaca gctcagtctc
     5101 gatcatgaac cgcggcacgt gcccccacgc catgccgtgc atgatcagct ccttcttcat
     5161 gagatggtcc ggaacagagg tctggggcgc gccctcgacc aggaaatggc cttgttcgga
     5221 cggatgccgc gacgagtccc ggaccacgca ttgggtgagg gcctgcatcc gctgcggtgt
     5281 gatgtcggtg tccggaggga agggcaggaa cccgggtgcc acgacgggca ccagggcgac
     5341 gcggccgagg tcgatccact ccatccgtac gtcgctcttg gggacgcggt gcacgatgag
     5401 gtcggcttcg tcttccagca gccgctccca ggggccggtg acggtctcga atagcaggtg
     5461 cagtcgtgtc tgcgggcact gagcgaagaa gctgctgagt atctccagca ccggtggaag
     5521 cggacacagg tccccgagca ccacgcgcag ctcggactct tcgcccatcg ccaactgcac
     5581 ggcgtaggtc tgcagttcct cggcgtcatg cagcaggacg cgcaccttgc ggtggaaggc
     5641 gtgcccgacc tcggtcagct gaacccgata gcccgagcga tccagcaggt ccagacccag
     5701 ctggcgctcc agcttggcga ccgctgcgaa gacagaaggg tgcgagcggt gcaatagatc
     5761 ggcggcggcc tggaagccgc cgccgcgcac aacggcgttg aagcactgca actcatggag
     5821 cgtgaagttc gacattatcc agagaaccta cagtgtgtgt tcaatctttg taatagatct
     5881 ctgcatgcag tgtttctagg ctgagcgcat agccgctaga tcatggagct gacatgactg
     5941 ctcgaacccg caccgccatc actaccggag acggtgtccg catcgcctac cgcttcgacg
     6001 gtaatgagga caatcccgtg ctgctgcttt cgaactccat cggcaccgac ctccgcatgt
     6061 gggatggcca ggtgccagct ctgaccgagc acttccggct gctgcgctac gacgcacgcg
     6121 gccacggcgc ctccgatgcc ccgagcggcc cgtactccat ggaccggctt gggcgcgacg
     6181 tggtggagct gctggatgcc ctgggcctgc ggcgggtgca cgtgttgggc ctgtctctgg
     6241 ggggaatggt cgcgcagtgg ttggggatcc atgttccgga gcgtgtcgac cgcctggtgc
     6301 tctccaacac cgccgcgtac ctcggcccgg cgaatcaatg ggatcggccg atcgcagaac
     6361 tgctggaggc ccccgacatg caggtcatcg cggagaggtt cctgaacaac tggttcccgg
     6421 cccgcatgct gcggggcgac aacgaggttg tcgagggttt ccgccgcact ctgctcgcca
     6481 cgcggcgcga gggcgtggcc ggcagttggg ctgcggtgcg tgactacgac ctgcgccgca
     6541 cggccacact catccagaac ccgaccttgg tcatcgcggg cgagcatgac accgtcacgt
     6601 cggccgacca cggcaaggag ctcgccgcga ccgtacccgg ggcgcggttc actgtcctgc
     6661 ccacagtgca catggcgaac gtcgaagggc agacgaagtt cctggaggct gtggtggcgt
     6721 tccttacaga agggtcttac ctgtagcgaa aagcggaggg tggcatgggc gtgagtagcc
     6781 gcagggctgc ccgggacgac tgggcagccc tgcggtatgg agaatcttcg tctcagggcg
     6841 tgacagtcct ggcttcttcg ggattctgcc cgtcggcttg ttctcatcga gctacggcgc
     6901 gggcccgaac gcggcacccg cgtgcaggag ctgtccgagg cagcagggct ggaccagtgt
     6961 cctctacgta tcgccttgtg acgcgcctga agcgcaaggg gctcacggcc ggagtctcct
     7021 gcaagcgtga tcgccgctgc gtgtactgac gtcttgtccg ccgtgcctca tcatccactg
     7081 acccggtgcg gtccgaccgc tacaacgccg gtcgcatggg tagttcggag aaggtctgct
     7141 gtgctcttcc tgcaaccggc cggacggcga ttactttcgg cgcctgtgga tgtgtgtgca
     7201 ctccccaccg cactgcttcg aggagtgctg gcgctcccct cccgcgctgt ctctcgggtg
     7261 ggtgatgctc aggtcggccg tcttccggca cgcggcgggg tgctgactgg ccaccccgca
     7321 ggtgccatcc attcccaggg ggaggcgaga acggttgaag gcagcctcgc tgctcgctcc
     7381 gcatccagaa aggcgtgcag gcgctgcccc accaccgaag gtgtcccggc ggaggaagcg
     7441 gaccccgcga gctgctcgtt catctcagat acctgcgcct caccggtgtc cgtgctgggc
     7501 gtcccaggag cggcacaggg cggtgaattc ctcctggcgc tcggccagga ggtcgagggg
     7561 gcgttggagg agcgcagtag aagagcgtcg ggcgcttgcg cgtcgaagac cgtctgaatc
     7621 cttgctggca cgcgctgcgg caactccttt cgggggctca gctgctgagg tcaaccacgc
     7681 cccacgcggt gaacggctcg gcctggacgt agatcctgct tcctcggctg acggcgcggc
     7741 ggcggccggg caggtggccg tcgggcaggg tgagcaggcc gacgtccgtt ggctcgacgg
     7801 atgcttcggt gagctctccg cgggtgagcc ggtccacctc ttcgccgtag ccgccgtaga
     7861 gggcgacccg ctcgccgtgg acggccactg ccttggcgcc ccgtacctgg ttcagccaca
     7921 ccctcgcggg tcggtcgggg cgtatctcga cgagcgggaa gtcggtgtac gtgcacgccc
     7981 aagcggtggt gcccgacacg ttcagggcgt agcagtcgaa gaggccgggg atgtttgcgc
     8041 cgtcggacgt ccagtaaatg tggccctggg ggctccagcg gcggattccg gccgggtttt
     8101 cgtcgaagtg cccgacccag atgtggccgg cctcgtccac gagcaggtgc tcgatcgcgt
     8161 ccccgacgga gaaggaggag gcctcgcggc cgcccgcgtc gaagacctgg acctggtcgg
     8221 cgtcctcgta ccggcgggcg cgggatgctg cgacgaccaa cgcgtcaaag ggcagggcat
     8281 cgccgccggg ctgcggagcg cggtcggcaa gcagccagtg ggcggtgccg aagacgtcga
     8341 cggtgctggt caggacgtgg cgagcctggt gcgctcgggg aaggtgggcg tagggaacga
     8401 gggcagtctt ctgcacgggc gggctctcct gggtgggcgg tcacggcgtt cgggcgctgc
     8461 ggtgagcggc ggcggtgcgc gagcggtgga gagcgaagcg gggcgcctag aaggcatggc
     8521 cctttctggt ggtcatgagg tgatcatcgt cgatgtgtgg cccccgcgcc agagcctttc
     8581 ggtccagcgc tcacgccgtc tgtgatgctc ggccggtacg cgggtgaggg gctggtggtg
     8641 ctgctcggtc cggcgtcgga gccgctgcgg gcgcgcgctc gccggtagcc gcccggatat
     8701 cgccgagagg ctcctcgcac cgtggcggga ggccgtcggt ggcgggctgc ggctggagat
     8761 cgtgtgctgg gggctgtccg gcaccggcgc tggatcggtc cgcctggccg cgcacaccct
     8821 ggcgctcgcc gaccgcctcg gcatccccgc cgtactgacc aacgccgtac ggtacgccga
     8881 ccggtcccag cgccgggtcg cggacgtcct ggacgcggcc cggctgctgc ggcccgtcga
     8941 ccggctgcga ctggactgcg gggagcggtg gctcaaggac ggcgcgacga tgaccgagat
     9001 cgccgagcgg gtgacggccg ccgccggagg tggccgggcg cgtgccgtgc ggctgctggc
     9061 cgacaccgtg gccgtcgcgg aggcgagcgc ggtcgacccg gtgagggatc tgaggctccg
     9121 cgagaaggat ctgtcacctc ctgagcacct gggcccccgg acccgagacg gcgccgtgca
     9181 cagccccgca ggctattcca ggactagatg gcacgggtga gggcccacac cgtggtggcg
     9241 cgggccctca cccgttctgg aacagctgca gccggggtgg acccggttgc cgagtcagcg
     9301 gacgaagtag ccgcgctccg cgtcgaagta ggccttctgg cccttgatgt aggtgatccc
     9361 gtacgggccg ccgaggttgc ggtactcgcc gctggcccag cccccctcga tctccgcgtg
     9421 gccgccgccg gccgggccgt cccagccgtt cgtcccgtgc gcggcagccg ggcccgcggc
     9481 gacgaacccg gctgcggcga cagccgccag cgtgatcgcg atacgacgca tcatgaaacc
     9541 gctctccatt catgtagtcg gtacgtgcag tgcgaccacc ctgaccaacg aaaccgccca
     9601 cggcatatgc ggcgcgcgga taccccgaca aggagaacct gttcggcccc cggcgcggct
     9661 cacccgtcga tggtttctct tcaggcggcc ccccgagcac agcgcctggg cccgcagctg
     9721 ctcggctcgc tgctcgtcga gcataagaag tgctgctacc ggggcgggcc agcgtgcacc
     9781 cgtttccgtg ggccatatgg gcgtggtcgc cgtcgtcatg acgtgttcgg ggtgtttctc
     9841 cactcggagt gtgcgaccgg cgtgatcgtc tctgcatcag agcctgcttt cgcgcagcgc
     9901 gactactgat ctgaagggca cgaacgcatg cgtttggggt acgcgccagg ccgcggtgac
     9961 gaatcgttcg tcatcaccac tgatctcggg aaggcatgag atgggccgtc accactgcca
    10021 ctcgtccgag gacgcccagg tcgtggactc ggacgtggtt gatgcggtcc tgcgcaccgc
    10081 gcgggcagtg ctggcggacc gagtcgacga ggccttacgg agcgacgtct tgttctgcga
    10141 ggagttggcg cggcgggtcg cggacttcac gctggagggc ggtaagcgta cgcggccccg
    10201 ccttctgtgg tgggggatgc gttcctgtgg cgcggctgag actgcggcgg cgctgcggct
    10261 cggggtggcg ctggagctga ttcagagctg cgcgctgatt catgacgatg tgatggaccg
    10321 ttcgcggctt cgccggggga agcctgccgt gcacatcggt ctggcagagc gtgcgggtct
    10381 ctcgccggat tccgagcggg gttcggtctt cggtacttca gccgccgtgc tggcgggtga
    10441 cctcgcactg gcctgggcgg acgacacggt ggcggagacc gtactgtcgg ccgtccagcg
    10501 tcgtcggatc ggcgccctgt ggcgggccat gcggaccgag atggtcgccg gacagtacct
    10561 ggatctgcgt ggccaggtca gtggcgagtc atcagtggcg caagccttgc ggaccgcctg
    10621 tctcaagagc gcttcgtatt ccgtcgagcg gcctctggcg ctcggcgccg ccttggcagg
    10681 cgccgatgag cggaccacag acgctctgcg ctccgccggc cggtgtgccg gtatcgcgtt
    10741 tcagctgcgg gacgatctgc tcggggtttt cggcgacccg gggctgaccg ggaagccgtc
    10801 cggcgacgat atccgcgagg gcaagccgac ctacctgctg gctgtcgccc ggaggtgggc
    10861 cgaagcggcg ggcgacgaac aggcactggc cctactcggt cgcgtcacgg gcaccgccga
    10921 cctcaccgag gaggatctcg cggacgtacg cggcgtgctc gaggtgacgg gggtgcgtgc
    10981 ccatgtggag cggaaagcgg aacgtctcca cgactacgcc gtacgtcgtc tgggacaggc
    11041 cgtcgacgtg gatgcgcacg gcggccgcca gctgctcgat ctgctgcgca cggtttctgg
    11101 agagcggtct ggccactccc ccaccgccgg cgagacgcgc agcggggcgg cggatgtcta
    11161 ctcggtcctg atcgcggccg aaggaggtag tgccgggtga tcacggtcat ggggcccgtc
    11221 gaccatgtgg tggtggtcgg tgccggtctg gcaggactgg ccgccgcgct gcatctgctg
    11281 ggcgcgggcc gccgcgtgac ggtcgtcgag cgggaaggcg tgcccggtgg tcgtgctggg
    11341 tttctggagt cgggcggctt ccgtatcgac accgggccga ccgtgctgac gatgccggat
    11401 ctggtggagg aagccttcgc cgcggtcggg gagcggatga ccgaccggct ggagctgatc
    11461 aggctggccc ccgcctaccg ggcccggttc gccgacgggt cccagctcga cgtgcacacc
    11521 gacggtgctg cgatggaggc cgccgtcgag gagttcgcgg gggcccggca ggcggtcggc
    11581 taccgacggc tgcggatctg gctggagcgc ctctaccggg tgcagatgca ccgtttcatc
    11641 gacaccaact tcgactcacc gctccagctc gcccatcccg acctcgtccg cctcgcggcg
    11701 ctcggcggtt tcggccggct cgacgcgcgg atcgggcact tcgtctcgga cgaacggctg
    11761 cgcagggtct tctccttcca ggcgctgtac gcgggcgtgc cgccggcgcg ggccctggcc
    11821 gcgtacgcgg tgatcgccta catggacacg gtggccggtg tgtacttccc tcggggcggc
    11881 atgcacgcgt tgccccgcgc gatggcggac gcggccgtcg acgcgggagc ctccctccgc
    11941 tacgggcaga gcgtgacccg gctggagcgc tcgggtgacc gggtcaccgc tgtcgtcacc
    12001 gaccaggaac gcattccgtg cgacgcggtc gtcctgactc ccgatctccc catcagctac
    12061 cggctgctcg gccgcagccc acaccgcccc ctgcccctgc ggcattcgcc gtccgcagtg
    12121 atcctgcacg cgggcacgga ccgcacctgg ccggaactgg cgcaccacac catctctttc
    12181 ggtgcggcct ggaagaggac cttccacgaa ctcacccgca ccgggaagct gatgtctgac
    12241 ccctccctcc tcatcacccg gcccaccgcg agcgacgcgt ccctcgcacc accgggcagg
    12301 cacctccact acgtgctcgc tccctgcccg aacaccgagg tcgggcccgg cgtacgggaa
    12361 tggcgggagc tggggccccg ctaccgggac gagctgctgg ccgagctgga gcgccgcgag
    12421 atgcccggcc tcggcgcggc gatcgaggag gaggggctgg tcacgccggc cgactggacc
    12481 gcccaggggc acgccgcggg cacccccttc tccgtggccc acaccttccc ccagaccggc
    12541 cccttccggc cgcgcaacct ggtgcggggc acggtcaacg ccgtcctcgc cggctgcggc
    12601 accacgcccg gcgtcggcgt gccgaccgtc ctgatctccg ggaagctggc ggcggagagg
    12661 atcaccggcc ccagagccgc ccggaccccg cgccctgccc ggagaggttt tagcgcatga
    12721 ccgtccacga actcgacgca gcaggcatcc atgaccccgc gctccgggcc gcgtacaccc
    12781 gctgccgcgc tctcaacgcc cgtcacggca agacctactt cctcgcgacc cggctccttt
    12841 ccgccgaccg gcggccggcc gtccacgccc tgtacggctt cgcccgccgg gccgacgaca
    12901 tcgtcgacga tctcggcagc actgccacgc ccggggatcg cgcccgcgcc ctgctcgccc
    12961 tggaagccca gctggagacg ggacggcggg gggcccgggc cgccgagccg gtgatccgtg
    13021 ccctggccga cacggcgggc cggtacaaca tcgaccatcg acacttcacc gacttcctct
    13081 cctccatgcg cagcgacctg acggtcggcg gctacgcgtc gtacgaggaa ctcggccggt
    13141 acatgcacgg ctcggccgcg gtgatcggtc ttcagatgct gccggtgctc ggaacggtgg
    13201 tggcgcgcga ggaagcagca ccgcacgcgg ccgcgctcgg tgtcgccttc cagctgacca
    13261 acttcctgcg ggatgtgggc gaggacctgg accggggccg gctctatctg ccggccgagc
    13321 tgttggccgc gcacggggcg gaccgggaac gtttcgagtg gagccggagt acggggatgc
    13381 cggacgcccg gatcaccgac gtactgcggg ccgccgcagc ccacaaccga accgtctacc
    13441 gggccgccct gcccggcatc gcgatgctcg ccccggtatc gcggccctgc atccgtacgg
    13501 cgttcgtgct gtacagcggc atcctcgacg cgatcgaggc ggacgggtac gcggtcctgc
    13561 accgccgggc ggtcgtcccg cgccgacggc gggccgccgt agcgctggac ggcctggtgc
    13621 gggcggtcgc cgcacgcaga gtgcgccggg gccgagcaga cacggtcgcg gcggtccggt
    13681 ccgacggggc gtcccggccg cggacggccg gcgccccggc cccggtgcgg gaggaggccg
    13741 tatgagcccg gcggcaggac gcccacgatc ccggcgcatt cccttgcggg tgcggcgcgc
    13801 gcccgtcccg tgggagcgtc aggcgcccac gtggcacgag gcgaaacccg gactcatcac
    13861 ggaggccctc aagcgtgcgc agagcaggcc ttccggcaat tggtacgtca tcggcgcctc
    13921 gcgcgacctt cctcccggga aggccctcgg cgtcacggtc ggctccaccg aagtggtggc
    13981 gtggcgcgac cgcgggggaa agctgcgcac cggtccggga gcgtgcccgc atctgggggc
    14041 gccgctgtgc gacagccccg tccgctgcgg cacgctggtc tgtcactggc acggactcgt
    14101 actggacggc gaaccgttcg ccggatggga gccctatccc gctttcgacg acggggtcct
    14161 tctctgggtg cggctcgacc gcatgggggg cgagccccct tcggcacgtc cctacgtacc
    14221 cgcccggccg agggcgcggg acgccgtgga ggcggtctac tccggcgtag gccgctgcga
    14281 gccggaagac gtggtggcca accgcctcga tccgtggcac ggcgcgtggt tccacccgta
    14341 ctccttcgtg gacctgacgg tgacgggaac ccctgccgac agcccggcgg acgacgccgg
    14401 gttcaccgtc gatgtgtcct tcaaggtggc cgggcgtctg gtggtgccgg tccgggcccg
    14461 gttcacggcg cccgagcccc gtacggtcgt catgcacatc gtcgagggcg agggtgcagg
    14521 gtccgtcgtg gagacccacg ccacacccat cgctccggac gagcggggca agccccgcac
    14581 ggccgtgacg gaggcactgg tcgcggcgtc ggaccgtcgt ggattcgccg tggcccgggc
    14641 ggccgctccg ctgatgcgcc ccctgatgcg tgcctcggcc ggccggttgt ggcgggacga
    14701 cctggcgtac gcggagaggc gctgggaact ccgcgacagc gggacgttcc cgggctgacg
    14761 agtggccccc tttcataggc tccgcagggc ccctccgtca gtcggccagc gcggcgagcc
    14821 ggcgcagaac ggccgaccgt cccccgcgcg ggacggtcca gagcgtctgt ccacgtacgc
    14881 cccaccgttc cagcagggcg ttcgcggcga ggaatccgct ggtggccgcg cgttccatca
    14941 gggccacggg cagatcggtg cggaccatgt ccccggccac ggtgaccgtg gggtcgaggc
    15001 tgcgcacgcc gggccggtcc cggtagccgc ccacggggaa catagggcag tccgcccgcc
    15061 attcgtggcg ctcgtccagg atgcgggcgc tgcgggtctc ggggtagatc cggtgcagct
    15121 gtctcagcgt ctcgtcctgt accgcggacc ggtcgcagtc cggtgcgacg gcgtaggcgt
    15181 ggagctcgac gaccgagcct cttgtacgcc gggcccagcg ggcggcctct ccctcccagc
    15241 ggtcgaggac gctcacgttg tccagcggac cgtagccgct ggtgcccagg aaccccggcc
    15301 ggtcgtacgc cacgggccgg tcgagccaga gccgtgagac caaaaacggc ggggcggtgc
    15361 gcagccgtgc gatccgtgcg cgccagtcgg tgtcgcccaa ctcgggagac gcggcgacga
    15421 ggcggcgcag ggcgccgctg tccagggcga ggacgagggc gtcgtactgg atggtgcggt
    15481 cgtcggtcgt gaggtccagc ccgccgttgg gcagggggcg aacctgccgg accggcgtct
    15541 gtgtccttac gtcggcgccg tggacttcca ggtagcggtg aagcggttcc cacagggctg
    15601 tggggaacgg ttcgccgggc acgtcgaaga gcaggccctc gctggagccg aggaagtaga
    15661 tgtggaacat cagcgccagt tcggccgccg acagttcacg cgggtcggcg aagaagctgc
    15721 gggagaagac ctcgaacgcc aggtggtggg cagcctcagg gaaccggatg cggtggagga
    15781 agtcggtggc gctgatcccg tcgagtcgtt cgtagacctc gggcacccgc acgtccagca
    15841 gccccaacgc cgccctcggg ttcatccggg tcaggtcccc cagaccgaat gtggggctga
    15901 gagcgacgaa ccccatggcg ctgagcggag gtgtgcgcgg cacccgagcg aagctgtccc
    15961 gcaggccgga gtcgtgccac agcggatagt cgggcagccg ggtcagggaa ccgaggtccg
    16021 ggtcgacccg acgcagaaga cctcgcaggt tgtagtactg ccggaagaac gcgtggaacc
    16081 cgcggctcat cgtcaccgtg gtgccgtcgg cgagctcggt gggccacccc gacagcctcc
    16141 cgcccaggcc cggttcgcgc tcgtggagag ttacgcgtgc gccgcgttcg gccaggaggg
    16201 tggccgccgc gatccctgcg atgccgccgc cgacgaccgc caccgcggga gcgtgccccg
    16261 tgaaccgggc gcggccggcc ggtgccggca cgactgccgc ctgccggtcc cggccgcgcc
    16321 ggtggcccct gccgctgtcc cgcaggaaca tcacgcctgc actcccgcgc ccgcggtggt
    16381 gcgaccgacg aaggtgtggg tgataccgct ctgccagctg ggcagcggga ggatgcgtac
    16441 gtcggcgaag ccggcccggc gcaaccgctg ggcgaacgcg ggagctgtgt cgaaccgggt
    16501 aacactgacc cgcaggtgac ggtagaggtc ggcgtctccg gcgagccgtc cggcaggctg
    16561 aatgatcagt gagcagaccg cgttccacag ggcacggtgg acgggtgatc cgccgagcgc
    16621 gtactcgtgg acggcgaggc ggccgcccgg tacgagcaga ccgcgcacca tgtcgagggc
    16681 cacgtcgggg tcggtgagat tacggaagag gtagccggcg aacaccgcgt cgaaggaacc
    16741 ggcttccagc cgtccggcca gctcctcgac cgggtgatgc gcgaagtcga cgctctgcgg
    16801 ccagctcttg gccgtcgcgc ggtccagcat tcctgcggac gcgtcgactc cggtgattcg
    16861 ggcgcgcggg gcggcagcga gaagcgcggc tgtggaagcg cccgttccgc atcccaggtc
    16921 gagcacgcgc agccctcttc ccccctccgg caggcccagt cggcgtgcgg agcggcgcag
    16981 gtgcgcgtgg tagccggggc tggccgagac gaggcggtcg tacgcggcgg agccgtggtc
    17041 gaaggcctcg gacagtgcgt caccgcgcag caaggtcatg gagtgctctc ttcgtgggcg
    17101 ggcggtgagg gaggaagcgg agccgctggg ctttcacgcc ggattctgaa ggggagctcg
    17161 aagacggtcc gcagcatggg ggccatcggt gtccgcaggc cgatgagcag gtcctcgtgc
    17221 agctgcgaac tgccgtccat gaagctgagc agccgctcgc cgggaacacc gcggaaaagg
    17281 cggctgaaga agtccgcgcc gttcaccctg ccgctgtcca gggcccgcag catcacggcg
    17341 tccatcatcc gcgcccgccg cccgtacggg acgggcatgc gcagggggcg tccggagcgc
    17401 aactgatcgg cgatggctcg gctctgtcgc tgcacggccg caaaggtgta accggtcgac
    17461 gggcgggtcg cgcctccggc ggttccgatg cgatacaccg aacgcccttg cctgcgcggg
    17521 aagcggccat ccgtcatggg gatgacaccg tgctcctgtg ccgtgacctc aaacggcccg
    17581 agcctcaaca cgtcgtgggt gtagtggcgc agagcacgcc ggtagccgtc ggcgtccagc
    17641 ggggcgggtg agaactcggt gtactcgacc agcgcggtgt gcgggacaag cggcaggaca
    17701 tagccgaacg agagcccgcg agcgggctgc gccgtacgga agtccatcaa gtccgcggtc
    17761 tccggatcga acacgggacg ctcggtgcgg acgaaccagc cggtgaaatg ctggaacagc
    17821 gtggtgcgag cgggcggcaa gtggtagggc ggccgggagt cgaagacacg tcggccgcgc
    17881 acgaggaccc gttcaccgca cgcgacctgg gtcagcacct caccgccggc gccggacgga
    17941 acgtcgcgta cggcactcgc cgtggcctcc atccggcgca gggccggcgc acgggacaac
    18001 cgttgctcga ccagcgcttc gaaagcgtcc gagcgcagca tcttgtagtg caaccgcgag
    18061 agcttcacca ccgtcgaagc tccgtcggct gcccgaaacc gcagccgggg ccaggaatgg
    18121 gccaggctct gatcgtaagg cccgcccggc ggctcccaga agcaccacgt ccgcgggggc
    18181 gccctcaaag gccccgaggg ggcatcgatg agggcgaccg ataaaggtac agcgctgcct
    18241 tgcgcgcaga ggtcgtatgc caggctcagc ccggccgcac cggcgcccac gatgacgacg
    18301 tcgaagtcag cggacacggc tttcctctcg gtctctctcg gtcgcggtga gggcgaagcc
    18361 ggcgcccttc acatcgaaac gccggtcggg ccgggttcca gatgaccgta tcccgctgtg
    18421 ctccctccga cccgacctgc gccgccgctc acacctgact ggcggtaagg gcggcaggcc
    18481 caggggcggc acgccagtgc tacctcaacc acgggtgatc acgagcatgt cggcctttgg
    18541 ctgctcgccc gggcacaagt tctcatcggc aggcattcat tcgcaccttg ccgcgccgac
    18601 acttcggtct cgcacgtgac caccgaagcc ctgctcaaac ctgccgtcgc tgcacttccc
    18661 ttgatgatcc gcacgttctg acaggccgtc ggcggtgggg tgcacgagat cgcggactgc
    18721 gcactcgatg ccgcgatggc cccggaggat cagcctgtca ccagtagtgc cgtcgtcctc
    18781 ccaccgcgtg ccccagggct ccgagagccc acagcaccgc gccgatggcc accaggatga
    18841 tcccgatggt ccacaggaca ccgatgccgg cgatcaagcc aatgatcagg agaatgaggc
    18901 cgaggatgat catggtgcct ccgatcatgg acattctctg ttaccaggtt cgctccgtcg
    18961 tgcccagccc acaaccgggg ggcggcccgg cccccggttg caccggcacg gcatttcgtc
    19021 ctggccgccg acggacagat cgccgtgaag ccgtacgccc tgctgcgcaa gcggaagatc
    19081 tggccgaacg actggcggat gagccacccg ctgcccgccc ccgacgcttc ccggtggggt
    19141 ctggtcccgc tgtcgctgca acagctgacc tctgcttgct cacctcaact caatcgtgcg
    19201 agaattcccg cacaattatt gtgcgactat tttcgaacaa ttaaggatgc cccgtgtcac
    19261 cgcggaccta ccaccaccca gacactgacg agatcgccat cccgcgagtg ctcttcgccc
    19321 tgagcgagcc gctgcggctg aacatggtgc gcatgctcgc caagcagggc gagaccgaca
    19381 gcatcgacct cggccccgaa ctgccgcgct cgacgttgac ccaccacacg agcctgttgc
    19441 gcgagtccgg cgtggtcttc gtgcgcgccg agggccgcaa gtgcatgatc cggctccgcg
    19501 aagatgacct cgaagcacgc ttcccgggcc tgctcggcac ggtgctcacc ggctacgaga
    19561 acgccgacga cgaccgcggg gagggcgacg catgatccgc aaggtgtggc ccctggccct
    19621 cgccgccgtc tcgctgggaa ttgacgcgta cgtgctcgcg ggcgtccttc cccggatcgc
    19681 cgactcgctg acgaccacgg tgtcgatgac cggcctgggc gtcacgacgt ttaccgccgc
    19741 ctacgcggtc gccgggccgc tgctgtcggg aaggcttacc cgcggcagca cggcacgggc
    19801 gctgctcatc gcgctcgggc tgttcaacct cggaaacctc gtcaccacga tcgcgccggg
    19861 catcgaggtc ttcctcgcct cgcgcgtgat ggccggcgtg ggcgcgggca tcctcacggc
    19921 cgtcgcgacc gccacagccg ctgcgatggt cgccgaccac gaacggggcc gcgccatgtc
    19981 cctggtgacc ttcgggctct ccgccggcac ggtcgcgggc gtgccggtcg ggatgatcat
    20041 cggccagagt gccgggtggc gctggaccat ggccctggtc gtactcatcg gcgtggccag
    20101 catggcggcg ctggccttcc gcgggaagac gctcccacgt ctcgacgcag cggcgggcgg
    20161 gtccgcgttc actgtgctgc gatcgagccg gaccagcgtc ggcatcgtgg ccgccttcct
    20221 cctgggcgtc gcgagccttg gcctttacac ctacctgctg cccatggccg aggaccgagg
    20281 gctcgggggc ctgggctttg ccctggtctg ggcctggggc atcggcggcg tcaccggctc
    20341 cgcgctgatc ggcaagccgc tcgaccgcta cggccccaag ccgctgctgg tcacgctgcc
    20401 cgccctgctg gcgctgagct tcgccgcggt atggctttcc tcttcgccga tcgtgtggtt
    20461 gatcgcggct gcggtctggg gcgcggccgg ctgggcgagc gtcccgacgc tgcagcaggc
    20521 actcaccgcg caccggcccg cgcaggcaat gtccatcatc gcgttccaga tggccgcgat
    20581 gtacctgggc tccgccgtcg gggccgccct cggcggcgcg ttgctcacct cgggcgacgg
    20641 cccggccgac ctcgcagcct gggcactcgc tcctgcggtt cttgccgtgg cgctcaccag
    20701 ctggatcgcg accggcgctc caacgcgtct ggcgccagaa cgggcacaga cagccgcctg
    20761 cgagagcaca gcatgaccga tcacgtcccc ggaccctatt ggcttcatca gcctattggc
    20821 ttcatcagcc ccggatcggc cacgccacgc gaactcgccc ttatgaggac ccgccacgtc
    20881 gggcggagcg ctcgccacct tcaccgagac cggacagctg gtgaagatgc gggtcgtccg
    20941 ccccagcgtg aggatcacaa gtacgggcag ccggcccggg ggctcccgcc cggcgctcgt
    21001 ccgcttctcg cccgcggggt tctggaggtc aaagatgccg cgtccgctgt ggaccggagc
    21061 catcagcttc gggctggtca cgatcccggt gaaggtcgtg tccgcgaccg aggaccacga
    21121 cgtgcacttc caccgggtgc atctggagga catgggccgg gttcggaccc ggaaggtctg
    21181 cgagctcgac ggcgaggtcg tcactcagga cgagatcggc aagggttacg agatcgcgaa
    21241 ggaccagacg gttccggtga cggacgagga gttggagcag atgccgctgc cgacggcgaa
    21301 ggcgatcgag atcgccgcgt tcgtcgacgc cggcacgatc gacccggtcc gcatcagcga
    21361 ctcctactac ctggccgccg acgggcaggt cgccgcgaag ccgtacaccc tgttgcgcag
    21421 agcgctggaa cggtcctcga aggtcgcggt ggcgaagttc gcgtggcacg gccgtgagcg
    21481 cttgggtctg ctgcggatcc gggagggcgc gattgtgctg cactccatga agtggcctga
    21541 cgaggtccgc agtcccgacg agctggcccc gcgcgaggtc gaggtcgggg aggaggagat
    21601 cgagcaggcc ctgcaactgg ccgagcggat gacgatcgag gacctgtccg gcttccggga
    21661 cgagtaccgc gaggccctgg aggacatcat cgcggcgaag tccgagggca agcccgttcc
    21721 cgccccggcc gaggacggga agcaggagaa gggcgaggtc gtggacctga tggccgccct
    21781 gaacgcctcc gtcaagacgg ctcaggaatc ccgcggcgat cgtggcgagg gcgccaccgt
    21841 gcacgagatg cggccgtcga agaagacgtc ccgaaaaaca ccagcgaaga agacggccgc
    21901 ttcgaagaag tccacggcgt cgaagaagcc tgcgaagaag acggccgcga agaagcgcag
    21961 tgcctcctga ccctcctcct gctgcgggtg ccgtcctgcc gaggatcgaa ccgatgctcg
    22021 caactcccgg gcctctgcca ccaacgaatg tggaggaccg gtgggcgttc gaggtgaagc
    22081 aagacggcca gcgggccatg gtctacctgc cgggtgacgg caccatagtc ctgcgagcac
    22141 gttcaggtac ggacatcacc gccgtctacc ccgagctcct ccccctcgcc gaggccctcg
    22201 gcgcacggag cgccgtgctg gacggggaag tcgtggcact cgacgatcag gaccgaagcg
    22261 acttcgagcg cctccagcag cggatgggcc tatcggactc ccccgcaaag gccgcgcgca
    22321 tggcggcccg ggtgcccgcg cacctgatgc tgttcgacgt cgtgcacctc gacggccagc
    22381 tcctgaccgg actgccgtac gcggaacggc gcgaacttct ggaaggcctc gggctggacg
    22441 ggcccgcctg gtcgacgccc gctgcgatcg tcggacacgg agcccaggcc tgggaggtgg
    22501 ctcgggacgc cgggctggag gggctgatcg cgaaacggct cacctcccgg tacgagcccg
    22561 gggcacggtc gaaaacctgg ctgaaggtca aggtccaccg cctcgccgac gtggtgatcg
    22621 gtgggtgggt ccccgggcgc ggccggctga ccggtctgcc cggagcggtt ctggtcggtg
    22681 agcggcgcga cggatcggtg cattacgcgg gcagcgtcgg caccggctgg agcgaggccg
    22741 aacgcgcccg cctcgccgag ctactccagg ccgcggccat cgacgcctgc cctttcgcgc
    22801 agatcccgca ggtggccgga gcccggtggg tgctcccccg gctcgtcggc gaggtccgct
    22861 actcctcccg tacccgcgcc gggcgcctgc gccacccctc ctggcaccgg ctacgccccg
    22921 acctggcacc cgaggacctg gcctgagagt gcgctgggcg gacgttcggg gcagggcgga
    22981 agctgcaggc ccttcgcgtg gggaggcccg caccctgtca gcaccctctg gacaagcccc
    23041 ccgtttcgaa ggggcggagc aactagattt ccgtactcgg tgccctgctg tggctcagct
    23101 gaacatgtcg agatagtgct gtgcgtgggc cgggtggtag tcgccgaagt cgacggatgc
    23161 cgggtcaccg cctgtctcgg cggcgacgag ccggtcgagg tagtagtccc agccggggcc
    23221 cactccgccc gccatcgccg ggtcgtcgcc gacggactgg gtgaaggtga gcgtggtggc
    23281 gccctcgtgc tcgacgagtg tgagagtcat gtgccagacg agttcctcgc cgggtacctg
    23341 cgacgtgagg accagacggc ggggggcctg gcactcctgg atggtgaaga gttccgccgg
    23401 gtggtcgtcg ccctcgtaga gcatccggaa ggcgaccgcg ccggtcgatg ggtcgccggt
    23461 ccattcgccg atccaccggg ccagacggtc cggctcggtg accgccgccc agacgtcttt
    23521 gatgccggcc cggaaggtgc ggtcgaaggc gatggtgtcc aggccgtcga tggtcacgcg
    23581 acgcccggtg ggggtgctgg tcatgcggat tcctcctgag gtcttccggt gccgggagcg
    23641 gcgtcgttgc cggcccggcg gtcgtggacg gttctgcgga cctccaggtc gagggcgtcg
    23701 aaggcgctct cggggatcgg ggagcggcgc ccggcgagct cgtcgagcag ggcgcggacc
    23761 ggggcgaggc ccgggcgggc gagcgcgtag tggcgctcgc gaccgtggtc ctcgacggtg
    23821 gccagccctg cctcggtgag cagtcgcaga tgcttgctca ccgcgggtcg gctgatcggg
    23881 tgctgtgccg cgaggtcgac cacccgggcc gggccggagg cgagggcgcg cagcaggtca
    23941 cggcgtatgg ggtcg
//
