LOCUS       NZ_CP074380            26447 bp    DNA     linear   CON 27-MAY-2024
DEFINITION  Streptomyces sp. MST-110588 chromosome, complete genome.
ACCESSION   NZ_CP074380
VERSION     NZ_CP074380.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. MST-110588
  ORGANISM  Streptomyces sp. MST-110588
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7915503)
  AUTHORS   Booth,T.J., Bozhueyuek,K.A.J., Liston,J.D., Lacey,E. and
            Wilkinson,B.
  TITLE     Bifurcation drives the evolution of assembly-line biosynthesis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7915503)
  AUTHORS   Booth,T.J., Bozhueyuek,K.A.J., Liston,J.D., Lacey,E. and
            Wilkinson,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-MAY-2021) Molecular Microbiology, John Innes Centre,
            John Innes Centre, Norwich, Not US or Canada NR4, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 28-FEB-2016
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 25.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022695595.1-RS_2024_05_27
            Annotation Date                   :: 05/27/2024 05:38:09
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,918
            CDSs (total)                      :: 6,828
            Genes (coding)                    :: 6,327
            CDSs (with protein)               :: 6,327
            Genes (RNA)                       :: 90
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 501
            CDSs (without protein)            :: 501
            Pseudo Genes (ambiguous residues) :: 0 of 501
            Pseudo Genes (frameshifted)       :: 350 of 501
            Pseudo Genes (incomplete)         :: 185 of 501
            Pseudo Genes (internal stop)      :: 14 of 501
            Pseudo Genes (multiple problems)  :: 45 of 501
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:56:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5722608
            Orig. end                         :: 5749055
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP074380.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Barrie Wilkinson, John Innes
            Centre, Norwich.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26447
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="23"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26447
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26447
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16447](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16447
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(667..1653)
                     /locus_tag="KGS77_RS24960"
                     /old_locus_tag="KGS77_24790"
     CDS             complement(667..1653)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025638.4"
                     /locus_tag="KGS77_RS24960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24790"
                     /product="DUF4365 domain-containing protein"
                     /protein_id="WP_242585198.1"
                     /transl_table=11
                     /translation="MSTVRSSRRIERAGVNALRALLEENDHIVQEIDGGNDHGEDMIVN
                     FTRGGKRTGCWIAIQVKSGKKYKRANGYAIPIEDHFDDWRQSRIPIIGVVYDMKKRELF
                     WVNLTENLKATDQHPGWVQIPNTSPLSEETVHQFYTDVATYVGDTRMHIRAATQEDALT
                     EAVRARQGLDPLTAPNPLFEGLASFTLRHEERLGVIAKDVRRSLPLLILVTIMAWEWPR
                     QIRFAEGSPTVSPTLWVLNLYAFMFFMALTMYFEFRAGRFPKETWRWLSVIASNFLWIP
                     FIDPDGDRGWWGTTWIIAGSITPVIGIAFLFIAFVRFARDRMKLRRT"
     gene            1809..2495
                     /locus_tag="KGS77_RS24965"
                     /old_locus_tag="KGS77_24795"
     CDS             1809..2495
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KGS77_RS24965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KGS77_24795"
                     /product="hypothetical protein"
                     /protein_id="WP_242585199.1"
                     /transl_table=11
                     /translation="MTRPSLPNPLEPVGHRRDGRPIYPILGASPEDDSNKPEGDGGTAG
                     GSVTQEDLSRLLAREKTQGGRAAVKKLLGDLGFDNSEALTEFITTKRDAEQAALTEIER
                     REQAAEEKLRAAEAREAQAAARERIAIRRAALAGLGAAGDDLSDAILLIDRALDDQPDA
                     DEDAVAAAAEQLKERRPELFGRISAVTPPAPGGSPAGGPPSRAGVPPKPGAAGLEMARR
                     RGFVTG"
     gene            2645..3064
                     /locus_tag="KGS77_RS24970"
                     /old_locus_tag="KGS77_24800"
     CDS             2645..3064
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009188454.1"
                     /locus_tag="KGS77_RS24970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24800"
                     /product="head decoration protein"
                     /protein_id="WP_242585200.1"
                     /transl_table=11
                     /translation="MTLQPITTSTSYTADRAWLASLHGTDSTETITLDLSKLTAGTHTV
                     ASTDTAQPYSRVLSGVPVGKITASGLYGAFDPTATDGRQNLAGHVFAEALFAPTAAKVP
                     AALLWHGVVVAAKVPGGIDPTKVTPSMTGPQIRYV"
     gene            3078..4133
                     /locus_tag="KGS77_RS24975"
                     /old_locus_tag="KGS77_24805"
     CDS             3078..4133
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009188453.1"
                     /locus_tag="KGS77_RS24975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24805"
                     /product="major capsid protein"
                     /protein_id="WP_242585201.1"
                     /transl_table=11
                     /translation="MTIQDLIKNVAARDLTTFARAIPSPADHLFTKDGGIIPTFEQDEV
                     KWRVKDNGRYVNVAKYRAFDASVPFASREAWQTTREGMLPPLGQKLLVGEQEQILLEAS
                     RGADEDRLVELLYDDTERHVEAIRSRVELAWGDVLVDGKFSLVAENGLTTEVDWGVPAG
                     NLPTVPKLWSDPTSDPIKDELGWIQYLDDRGAPFPELVVTSRKAFSFLAANNAYRAAYY
                     GSVNPSNTPTATLTPQQINVVRDNYGLPPITFYKGQVRVDGVQTKVLPEDRWIMLPPDR
                     AKWGQTIFGVTAEGLALSRGTNPEITKEDRPGIIITRGAQDDPVQIWTKGAAVGMPVLH
                     TPDAHIVAKVI"
     misc_feature    3096..3110
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            complement(4109..4252)
                     /locus_tag="KGS77_RS24980"
                     /old_locus_tag="KGS77_24810"
     CDS             complement(4109..4252)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KGS77_RS24980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KGS77_24810"
                     /product="hypothetical protein"
                     /protein_id="WP_242585202.1"
                     /transl_table=11
                     /translation="MRVRDLSGQFAVGFVTGLQHHPLAGRRVLDTYGGCKAAAHQITFA
                     TM"
     gene            4491..4817
                     /locus_tag="KGS77_RS24985"
                     /old_locus_tag="KGS77_24815"
     CDS             4491..4817
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063615.1"
                     /locus_tag="KGS77_RS24985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24815"
                     /product="hypothetical protein"
                     /protein_id="WP_242585203.1"
                     /transl_table=11
                     /translation="MDPILLAWLRAQLGTATDEQDLVTRYARLGRARSVAAEVLAERRA
                     KLLAEPLRMTVDGVVTIDQSNNLAGLERQITGLAELVAPDDPAVGEASADLVSAPLLPS
                     RRTR"
     gene            4825..5649
                     /locus_tag="KGS77_RS24990"
                     /old_locus_tag="KGS77_24820"
     CDS             4825..5649
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063614.1"
                     /locus_tag="KGS77_RS24990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24820"
                     /product="hypothetical protein"
                     /protein_id="WP_242585204.1"
                     /transl_table=11
                     /translation="MPYEWPPLVPGDPDEIARRVAAVLEDAWQRLAAKQREVITKFADN
                     ARAPYALATLEEFKKAIAAFRKRVDQEARQFVQRQLPHLYEEGVRTAAEALGTTFTWST
                     FHRDALQSLAADSYADFLRRSEEAERMASQFYRAARQAARREVPLLAAGNMTAKQAAKN
                     LADRLAAKHKLTHVVYRNGARVPVKDWAEAATLAKSAVAYNAGTLNRTRQAGVRVVEVF
                     DGSDCGWTSHQDPDKANRSLRSVEEAADWPISHPRCRRGFGPRPDAELPALV"
     gene            complement(5786..6025)
                     /locus_tag="KGS77_RS24995"
                     /old_locus_tag="KGS77_24825"
     CDS             complement(5786..6025)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.4"
                     /locus_tag="KGS77_RS24995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24825"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_347404591.1"
                     /transl_table=11
                     /translation="MNTHIPALELAPEDAWYKSSYSGGSGNSCVEIADVIAARGVVGVR
                     DSKDPSGPALQFSPAGWSSFVGLVRSGEADFGTV"
     gene            complement(6030..6914)
                     /locus_tag="KGS77_RS25000"
                     /old_locus_tag="KGS77_24830"
     CDS             complement(6030..6914)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641341.1"
                     /locus_tag="KGS77_RS25000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24830"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_242585205.1"
                     /transl_table=11
                     /translation="MAAKRGATGRRLELGLQLRGIRENILVNGKPMTRKVAVQGSRLSE
                     AALQRIETGGLNFRNVGDLRKLLAKYGVEDEETVESFVEMNRDATSQDWVTRYRGQVLP
                     AMQGFVGIEAEAQEIRIYHPQVVHGLLQTKAYAEAIFEIEKPIEETKTEFNQANVALRM
                     ERKQRVLEREPDPVKLWVILGEAGLRYLIGGPDVMREQYEEITRLCSLEHVKIQVLPID
                     AQGYRASSDLAILDLGDGLPPMVQVDNAWGAVSTSDKPKEVARFTRRFNEMIATALPPR
                     ETPEFMQRLAREL"
     misc_feature    complement(6861..6863)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7189..7734
                     /locus_tag="KGS77_RS25005"
                     /old_locus_tag="KGS77_24835"
     CDS             7189..7734
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="KGS77_RS25005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24835"
                     /product="ATP-binding protein"
                     /protein_id="WP_242585206.1"
                     /transl_table=11
                     /translation="MAVAALDPEILEELRTGCATNAIPTVLDYLSLTLDREYLTADGDV
                     PSTTAVWVGRVRRIGRAKLTVWGLSALVDDVQLLISELVTNGFRHGSGRHITFRLVIGA
                     GLLLMEVDDGSSVRPQLRDAGTDSLSGRGLFLVDAIASSWGVSSDGTRTWCTLNPLEQE
                     RRSECGAACLSAIRAPSL"
     gene            7689..8117
                     /locus_tag="KGS77_RS25010"
                     /old_locus_tag="KGS77_24840"
     CDS             7689..8117
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039764.3"
                     /locus_tag="KGS77_RS25010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24840"
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_242585207.1"
                     /transl_table=11
                     /translation="MRSSVLERDPGAVPLNHGGEAQNDDQTKARLLAALRARFLLESPE
                     IPVVDVIFDDLERILGEGAALTASEVASLTPRLHALYRRAVRASRHPNSGVRPATVAAS
                     HRLLFERFPPEFLPALAHLRRLALAVSDLLDELLEDMP"
     misc_feature    8010..8012
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8644..8847
                     /locus_tag="KGS77_RS25015"
     CDS             8644..8847
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018522503.1"
                     /locus_tag="KGS77_RS25015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5999 family protein"
                     /protein_id="WP_242587676.1"
                     /transl_table=11
                     /translation="MCQHQPPCPPAEASDREAARAAAHHPEQGWTLLCNGVLIFEDTGE
                     LLPDGRIVAPHRPLSNVVGAAA"
     gene            9369..9524
                     /locus_tag="KGS77_RS25020"
     CDS             9369..9524
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KGS77_RS25020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_242585208.1"
                     /transl_table=11
                     /translation="MPVQVSEEARDTPLPYKDHLLRPWFLASQLVRELRGVTVVDLERE
                     IATARL"
     gene            9742..9918
                     /locus_tag="KGS77_RS25025"
                     /old_locus_tag="KGS77_24850"
     CDS             9742..9918
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143559.1"
                     /locus_tag="KGS77_RS25025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24850"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_242585209.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.3e-12, bitscore:
                     44.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFQKTHATQEKPQGLGTTSDGFDLDVSLVEVSDTAGLISLTDDG
                     CGETCGACTTNVA"
     gene            10001..13072
                     /locus_tag="KGS77_RS25030"
                     /old_locus_tag="KGS77_24855"
     CDS             10001..13072
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612044.1"
                     /locus_tag="KGS77_RS25030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24855"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_242587677.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.2e-186,
                     bitscore: 620.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.7e-16,
                     bitscore: 57.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.1e-20, bitscore:
                     71.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPSTVYRAGKTALLRAVARPELPVPPCPDLDDSSPRGAAARLAW
                     LREVWTEEDLAEALEHASPALASQVRALCSSSSPVARDVRRAVASVARYVLRAEHRATP
                     FGLFAGVASAAIGPRTRAVWGSEHTVVGRASGEWLTAVVERLESCPELMERLLVVVNNA
                     TATRDGRLIVPYKSASEGDRRHAIEVSVALTGPVQTALEAARAPVPAGVLAENLAAEFP
                     AADSAKAQRLVRELVQHEGLITNLCAPSTETDALRYLLSQLDAVSADSVAPVADTVREL
                     HAVQLDLTSCGSRSGRARAAARMRAVVPDLKRHPLALDLCLDAQVELPQAIAQEIERAA
                     SVLTRVSAHPYGTAAWKAYQRRFYERYGIGTMVPLGEVLADSGTGFPDGYPGTRITEGR
                     SRLSVRDDTLVRLAQAAVLDGRDEVALTDDLISAMDVGPECPRVPPHLEVGVRVHAASI
                     EELHRGRFLLEIANVSRGVGVTIGRFLGVLAPEDRERLSPELADLPTADAGTIPAQLSF
                     PPLLSTSAHVTRAPQVLPTVISIQEYRDTGSDVLTPGDLAVACDGRRMYLAAPELGLRV
                     EAVGMHALNLTTHTPPLVRFLAELSRAQCAQVTLFNWGAANAMPFLPRLHYGRTVLAPA
                     RWRLDAAELPRHDRPQDQWDSALEEWRTRRRMPLRVVLAEDDRRLHLELDQAGHRNLLR
                     QHLNRVGLAVFVEAPAADAYGWSNGRAHEVVLPLKATRPPGWPALPTPTPARTFSPEQI
                     QTPGASSLLLTTLYGDPRRQDTLLAQHLPVLLDRLGGPPWWFIRFRDPDQHVRVRIALP
                     DPDAFAATARTVGIWANELRTAGLLSDMRFSTSYREMGRWGSGAAWDAAEEVFRSDSRA
                     IVAQLSQSNRPSQRALVAAHTIAIATAFLGSVEEGMHWLIEHIPPAAPTTVPRPQFTEA
                     VRLADPSGDWAALRGVPGGQAIAEAWADRDAALAAYRPHLPGPDTRGIRLDDVLSSLLH
                     VHFVRHIAVDFTEEEICLYLTRAAALAWMSRRAQ"
     aSDomain        10472..10744
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KGS77_RS25030_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.90E-18"
                     /identifier="RREFam001.1"
                     /label="KGS77_RS25030"
                     /locus_tag="KGS77_RS25030"
                     /protein_end="248"
                     /protein_start="157"
                     /score="57.9"
                     /tool="antismash"
                     /translation="VVVNNATATRDGRLIVPYKSASEGDRRHAIEVSVALTGPVQTALE
                     AARAPVPAGVLAENLAAEFPAADSAKAQRLVRELVQHEGLITNLCA"
     misc_feature    11225..11227
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13069..14343
                     /locus_tag="KGS77_RS25035"
                     /old_locus_tag="KGS77_24860"
     CDS             13069..14343
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543780.1"
                     /locus_tag="KGS77_RS25035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24860"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_242585210.1"
                     /sec_met_domain="LANC_like (E-value: 1.1e-43, bitscore:
                     148.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPLALKTVDAVADLLADPATAPTGPGDASLHRQHLAYGPTGIA
                     LLHIERAAAGLGPWQRAHDWLAAAARQPFTSGPDSHPFYGAPALAHAVACAADHLTGAY
                     ERARDSLNQRMSADVRRRLEAAHRRIDTGRLPELAEFDAIRGLVGYGAYFLRRDTTGAD
                     LRAILSYCVRLAEPVTCDGGACPGWWTPSGPSGRLDDRFPGGHANNGMAHGIGGVLALL
                     ALAARRGVTVDGHREAAYTILTWLDRWKEKTGRGGAWPYWVTRDELRSGRPDPSPRRRP
                     SWCYGTAGLARARQLAALAFGDTERQLDAENALVSALTDRGQLKATTDSGLCHGFAGLA
                     HIAARTAEGAHASTAGQLRAVIPSLLAAVCPPGTVPKDKAEAVVQARAAGPGFLNGAAG
                     MALALLAPAADAPPRSAWDTCLVIA"
     gene            14366..16447
                     /gene="fxlM"
                     /locus_tag="KGS77_RS25040"
                     /old_locus_tag="KGS77_24865"
     CDS             14366..16447
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543781.1"
                     /locus_tag="KGS77_RS25040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24865"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_242585211.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.9e-28, bitscore:
                     96.9, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 3e-45, bitscore: 153.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPDRWYQHNVTFADRATGKRAIADCLGPALLEAEKDGQLTAWWF
                     MNKQPWPLRYRSAAPSPLIESVLSDLVDDGAVRAWVPGIYEPETTAFGGPENMDAAHEL
                     FHQDSRHLLTYRPGPGRLGRRETAVLLISALMRAARLDWFEQGDVWAKAAELRPAPQEL
                     APDRATALGQAVKRLMTVDSRSLCRPGGPFDGHDEWVAAFERAGATLADLAARGGLTRG
                     VRAIVTHHLIFHANRAGLRSDDQSALFNIARKAVMGSSDNTASSAEGTPETTSVRAVNT
                     DTLANSEADAAQLRNALVDKIRESGYARTAAVETALRTVPRHLFVPDATLEDAYANTPV
                     NVKYDTDGTSISCASQPGVVALMLDQLDAQPGERILELGAGTGYNAALLAHLVGETGHV
                     TTIDVDDDLVEGARAHLAAAGFTNVEALIRDGAVGHADGAPYDRIIATVGAHGVPHAWM
                     QQLVPGGRLVVPQRLKGSVSRSIAYEQRDGRWTSVSSKMNTFMPLRRGIADDDRRVIPL
                     STDGTVRLQAPAGQPIDAQALAGVLDQPRTEKWTGMTVRAMESPEWMELFVSCSVPSGL
                     IRMLFPADAKGTLLTEDPYPSSTAAVDKGAVTYLARRVSEKKTPEGGKLWEFGVIGHGP
                     GGDELAARVVDAIRTWDREYRDREATFEIQPLDAPAIEQVPGLFALDTPLNRIVVDWR"
     gene            16544..17650
                     /locus_tag="KGS77_RS25045"
                     /old_locus_tag="KGS77_24870"
     CDS             16544..17650
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345939.1"
                     /locus_tag="KGS77_RS25045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24870"
                     /product="hypothetical protein"
                     /protein_id="WP_242585212.1"
                     /transl_table=11
                     /translation="MDPHGPIARRFPLVARFRPACSPLPARVRSLAELAVKATNQDDQG
                     VASAVFNQAALVASDTGLPDLARSMCHRHAEAYLRAGPLPAMSAIRGLEPLVNLARLQI
                     RAGHNDDGRQRLLDLYEAVGTGHTAVFEGITVPADLTCTDEDRREVHAWLWRVVLADGT
                     RSLTAQGRWREALSHIERHRGVGTRMLDGRQVAVVAALTEGHTERAVELLTGTAPGDAW
                     EQAVTACLTALCRRDTGQNLGDDADELVSTYFNQEAQPGRTVFDIRLGLTVLDAVGARH
                     PAAHQLVENLFLRTRETLDGYAAREVLAHALFTALVSDNQAQECRDMLLSCGLGTGIIA
                     DDLAGALSAALDAAEAVITRSLNAVTPR"
     misc_feature    17694..17709
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            17702..18133
                     /locus_tag="KGS77_RS25050"
                     /old_locus_tag="KGS77_24875"
     CDS             17702..18133
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039652.3"
                     /locus_tag="KGS77_RS25050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24875"
                     /product="DUF6093 family protein"
                     /protein_id="WP_242585213.1"
                     /transl_table=11
                     /translation="MSAPTEGLTLGAVSAIVEKKILTNKIRIYRPGKPVFNPDTGQYEP
                     GPPVTVYEGPGAIFPTGGPSVVLHIAGQAYVDDTPSRYRLLTPLSAPVASREDTVAIVE
                     AEDKSAIGRTWRVIDIGETSTLSIVRTTWVDQNTQTTGA"
     gene            18135..18560
                     /locus_tag="KGS77_RS25055"
                     /old_locus_tag="KGS77_24880"
     CDS             18135..18560
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039652.3"
                     /locus_tag="KGS77_RS25055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24880"
                     /product="DUF6093 family protein"
                     /protein_id="WP_242585214.1"
                     /transl_table=11
                     /translation="MTTAIDPEEVRQELEAKLLLDTVRVTRPTGTPTLDLSTGLLGEVP
                     ADLVYEGPGAMLSGHGQVTAEGIIGKQWLDDTVSWYRLLTPLGAPVPARYDRVEVTVAH
                     SGSAATGGRVWQVLDPAEASTVELVRVTRLDEITPPS"
     gene            18600..19004
                     /locus_tag="KGS77_RS25060"
                     /old_locus_tag="KGS77_24885"
     CDS             18600..19004
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KGS77_RS25060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KGS77_24885"
                     /product="hypothetical protein"
                     /protein_id="WP_242585215.1"
                     /transl_table=11
                     /translation="MEITDTPPADIQQIRVTADGSKASIQIAGIDYSRVVSGYTIHQQA
                     GEAADLVVQFAQGRTSPDFDGYARVAVGIPYEPGPAAAHFLSAIDPGLLEKEALARPDM
                     GGGPHGFTRAVLAQLQEWARGEFDQAKEAS"
     gene            19004..19435
                     /locus_tag="KGS77_RS25065"
                     /old_locus_tag="KGS77_24890"
     CDS             19004..19435
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016754.4"
                     /locus_tag="KGS77_RS25065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24890"
                     /product="HK97 gp10 family phage protein"
                     /protein_id="WP_242585216.1"
                     /transl_table=11
                     /translation="MASPRNPHPNAHPSAGAYSNAPQIAALLNSRAAAVLPAVASVVQH
                     YAMLLETAIKANASGRPGPNAPTGDYRRSWTHELNTSGLNIEAIVGTNKPQSRRLEYGF
                     VGADSLGRIYNQPPFPHVGPAVEHIRPAFLAAVGAAVGD"
     gene            19435..19866
                     /locus_tag="KGS77_RS25070"
                     /old_locus_tag="KGS77_24895"
     CDS             19435..19866
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KGS77_RS25070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KGS77_24895"
                     /product="hypothetical protein"
                     /protein_id="WP_242585217.1"
                     /transl_table=11
                     /translation="MAVSGRVLSLAVQAMLGTATGRSCGYGTAPTASSLPTGAATPYSV
                     LYPVGSTSDGPPFGDASADARIVYQITSVASTTEQAEWMADKVRAGMLARTTLGYTYPI
                     NATGYVVMSRELDKEEGVTVASGVYSYVQRFAIEVTSLG"
     gene            20004..20498
                     /locus_tag="KGS77_RS25075"
                     /old_locus_tag="KGS77_24900"
     CDS             20004..20498
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KGS77_RS25075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KGS77_24900"
                     /product="hypothetical protein"
                     /protein_id="WP_242585218.1"
                     /transl_table=11
                     /translation="MATTQQRFMRRGTTLFYFLQKITSDGNIPTRAELGPSNATNLSDT
                     ISDVEGWSLENTPIDTPDMGSTFATTIPGEDKADNSSLTFYEDKVSDEIETLLSKGVIG
                     FIVILRKGDVPQSKSMDVFPVRVGSRSPSYSTASEPAKFKVTFGITDEPALDAAVPAKT
                     V"
     gene            20513..21124
                     /locus_tag="KGS77_RS25080"
                     /old_locus_tag="KGS77_24905"
     CDS             20513..21124
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KGS77_RS25080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KGS77_24905"
                     /product="hypothetical protein"
                     /protein_id="WP_242585219.1"
                     /transl_table=11
                     /translation="MTTTAISEPPAAAVARDAHWSAKMARLKARQLPERSLRLCDDDEA
                     KKNATDAALELAKARTVARGQSIEQGVSEADREEWTVSQPEVVAAQLRLDAAEQVLEDA
                     TIVLTFRALPRPAWEQLLRDHPPTEAQADQGMEYNVETYPAALIAACHIERDESGGEVP
                     GMSEQEAQELLDAWPDSEAKALFTCALLVNQTLRADLGKG"
     misc_feature    complement(21270..21286)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     misc_feature    complement(21362..21380)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.7"
                     /tool="antismash"
     gene            21460..25731
                     /locus_tag="KGS77_RS25085"
                     /old_locus_tag="KGS77_24910"
     CDS             21460..25731
                     /GO_function="GO:0005198 - structural molecule activity
                     [Evidence IEA]"
                     /GO_process="GO:0016032 - viral process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01760.1"
                     /locus_tag="KGS77_RS25085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KGS77_24910"
                     /product="phage tail tape measure protein"
                     /protein_id="WP_242585220.1"
                     /transl_table=11
                     /translation="MAGAYTLYVQVQAGVTGLVGGLRTAAGQVTAFGGQVRRLDGDLNA
                     LAARSDRTRRAMATGFTVLGVAIGGAFVMGVRSAIELEKRMANVMTISKKINSTNISHF
                     TDQIVELSTQLPQSADQLAEGLYQVVSTGFDGADAMTILRVAARGAAAGLTTTETSARA
                     LLGVLKAYGMDASQASDVMDVMFQTVNYGVVSFTELAQQLGDVVPMAAAAGVKFEDISS
                     ALAAVTLSGIPAAEGVTALNMLLTRMMKPTQELSNMIRGFGYESAAAALQQDGLYVVMQ
                     KVRNATGGSADQLVPLLRDIRAVRAALALSAADGENYAATYQGISQEVERAGATQKAYA
                     IQMDTTAGQWSLFQNQAQALGIDMARVLLPALQGVGEYLNVLAGAINDLPGPVKSITGA
                     VLALSAAALLAKAAFLRFGAQLTVFRTNLAAARAGGSALPAVLSGAGIAVAGLTALMAI
                     GIGVYAAYSASKQKAKAATEELADALRKEREEGEQGAGLRTLTEQLTNSDDVKKLKDAG
                     IDVATAIDAITSGGAKLKKLKDKLHLQKASTWKIGSYAPEPEWDAAKEVLDKQHKIWSN
                     AVKQESQLAASMAIVNNKIKNNRREMRGAWDLTQSLPTDKNGKPQFTEQMEAMAKSLGS
                     IVDPARAWKAAQDKVAEANRKAGRSADASKASLSDYVAELRKQLKAQREFQKNLGDLAA
                     AGRLGLADHFSDLGPDSAPILDELVKQLKKGKGKVADELESIIRESSARSTPAFRAGLG
                     QLPAISAKYGKKVAEAWADAAATNDPKKLARVMRDMTVADMETAAKKLPKAAAAQLEQG
                     MGLLADVSARFGKEASTSLAQSFLKGDIGEIRSQLNALYGADLPIKAPDLTGVVGAFKA
                     AGVQSNSEWSGMLSLIVAVAQQKGTAAASALTTALLSGDMAAVQAQLDFIGASVGRIPG
                     TKTITVTVTKPAAVTIPFYAKFQPSSWDKDGNGVPDGIQAPKKQANGGLIDFYADGGVR
                     SRREEHTAQIAPAGAWRVWAEPETQGEAYIPLAGAKRARSKRILEEVARRFGGEVSYHA
                     DGGLSGFTYRPQTLYSLSGIASDSQDKKGHFSLALFLKKLHSSVATANRWRRDLNTVAR
                     RAGQDVADALAEMGEEGVSLTHKMATGSSRDVRSMAKDLRELAKASKASLGEYTGRLRQ
                     AVKDQTGFEQALAKLAASGFGDLAKRLAEQGDQDAADLAAQAVKDKKKAKAANDAARSA
                     GKTVPSDDLPDLVAIIGAVKSKTTGLHAVADATGLDEDHIIKIANLGLSRLKSALGAKG
                     AKFFSDLSRANKGLSYANGGILTPGLYATSDGLIKFAEPETQGEAFIPLGAAKRSSALS
                     VLNDVATRFGMRLASGAAPPSLRLVDARPPTAIKVTVVQQQPKALVENMPITVQGRDSS
                     PQELSREIMRRLRNAQRGGRI"
     misc_feature    23722..23724
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 atggcagctc aacgacaacg ggcgcatgga cgtcctcgac acatctgccc agctcgcaga
       61 actgcgcgcc cgcgtcgacc atatcctcga ccggatcgcc gcgaacagcc gcctcaccgc
      121 cgctggcctg ggcacgctgg acccgaccgc cctgccgtcc ggctacgccc tgcaactcgc
      181 actcggcccg ctggactcgc tcgtcgccgc gatgcgcctg gcccggaccc acaagtacgt
      241 cgtcctgctg cgcatggtgc aacgactcca ccaggcaggg caggcagagg gctggcccgc
      301 gggggagtcg cttcctgcgc gcctgatgtg ggggccgcac accccgaccg accgcgctgc
      361 cgtcctggat gaggtggtca aggccgtcgg cgccggggtc ctgtcggtgg agaccggcat
      421 tcgcatgctt atcgacgccg gatacccgat cgacgacgcc caagcggaga tcgagcgcat
      481 ccagtccaga gcctttgagg ccgctgcacg cctcgcggac gcaaccgggg acaacgccgc
      541 tgtgcgtgaa tacctcggcc ttccaaaagc tggactggag ctgccgagga tctcgtcgaa
      601 tagctttgta tccgaaccct cggatgtgaa tgataactga cgggaacttg gcgcccatta
      661 ggcgtcttat gtacgtcgaa gtttcattcg gtcgcgagcg aagcgaacga aagcgataaa
      721 caagaatgct attccgatta caggtgtgat gctcccggct atgatccagg tcgttcccca
      781 ccaaccgcga tctccatcgg gatctatgaa tgggatccaa aggaaattgc tggcgatgac
      841 tgagagccat ctccaggtct ctttggggaa gcgcccggct cggaattcaa agtacatggt
      901 cagcgccatg aaaaacataa aggcgtagag gttgagtacc cacagggtcg gacttacggt
      961 cggcgatccc tcggcgaagc ggatttggcg aggccactcc cacgccataa tcgtgaccaa
     1021 gatcagtagc gggagagagc ggcgcacgtc ttttgcgatg actccaaggc gctcctcgtg
     1081 gcggagggtg aagctggcca agccttcgaa taggggattg ggtgctgtca gggggtccag
     1141 tccctgcctt gcgcggacgg cttcggttag cgcatcttct tgagtcgccg cgcgaatatg
     1201 catcctagtg tccccgacat aggttgcgac atccgtgtag aactgatgga cagtctcttc
     1261 cgacagcggt gacgtgtttg gtatttgcac ccagccgggg tgttggtcgg tggccttgag
     1321 attttcggtc aaatttaccc agaagagctc tcttttcttc atgtcataga cgactccgat
     1381 gattggaatt cgactctggc gccaatcgtc gaagtggtct tcgataggga tcgcgtaccc
     1441 atttgcgcgc ttgtattttt tgccgctctt tacctggatg gcgatccagc agccagtccg
     1501 cttcccgccg cgcgtgaagt tcacgatcat gtcctcgccg tgatcgttac ctccgtcgat
     1561 ctcctgaacg atgtggtcgt tttcctcaag gagcgcgcga agagcattga cgcctgccct
     1621 ctcaatgcgg cggctagagc gcacagttga cactggtccc ccttcgatcg acgacggtca
     1681 ggatacggga tggcactgac agtgatcttg cctcgacggg gtacgtcagg gctgagctgg
     1741 acagatgctt gcgctcgcta cactgatcaa tggcgcgggg gcgctggaga tctgtggatg
     1801 gttcacgcat gacgcgcccc tcgctcccca acccgctcga accggtcggg caccgccgtg
     1861 acgggcggcc gatctaccca atcctcggtg cttcacccga ggacgactcc aacaagcccg
     1921 aaggcgacgg cggcacggcc ggcgggtcgg tcacgcagga agacctgtca cggctgctgg
     1981 cccgcgagaa gacgcagggc ggacgcgccg ccgtgaagaa gctgctcggc gatctcggct
     2041 tcgacaactc cgaggcgctg accgagttca tcaccaccaa gcgcgacgcc gaacaggctg
     2101 cgctgacgga gatcgaacgc agggagcagg ccgccgagga gaagctgagg gcggccgagg
     2161 cccgcgaggc gcaggctgca gccagggagc gcatcgccat ccgacgcgcc gccctcgccg
     2221 gactcggcgc agcaggagac gacctcagtg acgcgatcct cctcatcgac cgcgcgctcg
     2281 acgatcagcc cgacgccgac gaggatgcgg tggctgcggc tgccgagcag ttgaaggagc
     2341 ggcgacccga gctgttcggt cggatcagcg cagtcacacc gcccgccccc ggcggttctc
     2401 ccgccggcgg tccgccttcg cgtgccggtg tgccaccgaa gcccggcgcg gcaggactgg
     2461 agatggcccg gcgtcggggc ttcgtcaccg gctgaccagg tcaagcgacg tcatggcgca
     2521 caccatgacc ccaccggcgg gatagccgga cgtggggacc acgccccttg cacctcccgt
     2581 ggacggcgcc acaaccaggt gagcgcgcga atccgattcg cttcacgtcc atgggaggac
     2641 ggctgtgaca ctccagccca tcaccacgtc gacgtcgtac actgccgacc gggcctggct
     2701 cgcgtcgctg cacggcaccg actccaccga gaccatcacg ctcgacctgt cgaagctgac
     2761 cgcgggcacg cataccgtcg cgtcgaccga caccgcccag ccctacagcc gagtcctgtc
     2821 cggcgtaccc gttggcaaga tcaccgcgag cggtctgtac ggggcgttcg atccgacggc
     2881 gaccgacggc cgccagaacc tcgccggtca cgtcttcgcc gaggctctgt tcgcgccgac
     2941 cgccgcgaaa gtgcccgccg cgctgttgtg gcacggcgtc gtcgttgctg cgaaggtccc
     3001 cggcggcatc gaccccacca aggtcacccc gtcgatgacc ggtccgcaga tccggtacgt
     3061 gtgagaggcg gccgacgatg accattcagg atctgatcaa gaacgtcgct gcccgcgacc
     3121 tcacgacctt cgcccgcgcg atcccctcgc cggcggacca cctgttcacc aaggacggcg
     3181 ggatcatccc gaccttcgag caggacgagg tgaaatggcg ggtcaaggac aacggccggt
     3241 acgtcaacgt cgcgaagtac cgggccttcg acgcgagcgt gccgttcgcg tcccgcgagg
     3301 cgtggcagac tacccgtgag ggcatgctgc cgccgctggg tcagaagctc ctcgtgggtg
     3361 agcaggagca gatcctgctg gaggcgtccc gaggcgcgga cgaggaccgg ctggtcgagc
     3421 tgctgtacga cgacaccgag cggcacgtcg aggcgatccg ttcccgagtc gagctggctt
     3481 ggggtgacgt cctagtcgac ggcaagttct cgctcgtcgc ggagaacggt ttgaccacgg
     3541 aggtcgactg gggcgtgccg gcgggcaacc ttccgaccgt gccgaagctg tggtcggacc
     3601 ccacctccga cccgatcaag gacgagctgg gctggattca gtacctcgac gaccggggtg
     3661 ctcccttccc ggaactggtg gtcaccagcc gcaaagcgtt ctcgttcctg gcggccaaca
     3721 acgcctacag ggcggcgtac tacggctcgg tgaacccctc caacactccg acggccacgc
     3781 tcactccgca gcagatcaac gtcgtgcgag acaactacgg cctgcccccg atcaccttct
     3841 acaaggggca ggtgcgcgtc gacggcgtcc agaccaaggt gctcccggag gaccggtgga
     3901 tcatgctgcc gccagaccgt gcgaagtggg ggcagaccat cttcggcgtg accgccgagg
     3961 gcctggccct gtcgcgcggc acgaacccgg agatcaccaa ggaggaccgt ccgggcatca
     4021 tcatcacccg cggtgcccag gacgatccgg tccagatctg gaccaaggga gcggcagtcg
     4081 gcatgcccgt gctgcacacg ccggacgctc acatcgtcgc gaaggtgatc tgatgggccg
     4141 ccgccttgca gccgccgtac gtgtcgagca cccgacgacc cgcgagtggg tggtgctgaa
     4201 gcccggtgac gaacccgacg gcgaactggc cgctgaggtc acgaacccgc atgcgtggga
     4261 ggacgacgag ccaacggcca accaggagga gcctgagtcc gacatgccta agtaggaggt
     4321 gtcgccgccc ttcggcttca ccgggcagcc cgaggccgag gccgagcccg cgcagccggc
     4381 gccacggcgg caccggaagg ccgccgacac cgacgagtaa gcacacgaga tacgtcagcc
     4441 cgttcccgcc cgtccaggcg ggggcgggtg acggccatcc aggagcactg atggacccga
     4501 tcctcctcgc ctggctgcgg gcgcagctcg gcactgccac ggacgaacag gacctcgtca
     4561 cccgatacgc acgcctcggc cgtgcccgct ctgtcgccgc cgaagtcctc gccgagcgcc
     4621 gagccaaact gctcgccgag ccactgcgca tgacggtcga cggcgtggtc accatcgacc
     4681 agagcaacaa cctcgccgga ctggaacgcc agatcacggg tcttgccgaa ctcgtcgcac
     4741 cggatgaccc ggctgttggg gaggcgagtg ccgacctggt ctcagcgccg ctcctgccgt
     4801 cccggcgcac gaggtagggc ggccgtgccg tacgagtggc cgccgctggt accgggagac
     4861 cccgacgaga tcgcgcgcag ggtcgccgcc gtacttgaag acgcctggca gcgcctggct
     4921 gccaagcagc gcgaggtgat caccaagttc gcggacaacg cgcgagcgcc gtacgctctg
     4981 gcgactctgg aggagttcaa gaaggctatc gcggccttcc ggaagcgcgt ggaccaagag
     5041 gcacggcagt tcgtacagcg tcagcttccc catctgtacg aagagggcgt gcgcacggct
     5101 gccgaagccc tgggcacgac cttcacctgg tccacgttcc accgtgacgc gctccagtcg
     5161 ctcgcagcgg actcctacgc cgacttcctg cggcgctccg aggaggccga acggatggcc
     5221 agccagttct accgtgccgc gcgccaagct gcgcgccgcg aggtgccgtt gctggccgca
     5281 ggcaacatga ccgcgaagca ggccgccaag aacctcgccg accggctcgc cgccaagcac
     5341 aagctgacgc acgtcgtgta ccgcaacgga gcgcgcgtcc cagtgaagga ctgggcggag
     5401 gcggcgaccc tggccaagtc cgccgtcgcc tacaacgcgg gcacactcaa caggacacgg
     5461 caggccggcg tacgagttgt cgaggtcttc gacgggtccg actgcggctg gacttcgcac
     5521 caggaccccg acaaggccaa ccggtcgttg cgtagcgtgg aagaggccgc tgactggccg
     5581 atcagccacc cccggtgtcg tcgaggcttc gggccccggc ccgacgcgga actacctgcc
     5641 ctcgtatgac acgttcaccg cgacgagggg cctgtttcgg tgcgaacatg gcatccccgc
     5701 cttcccgcaa ggcgaatacc gatgaccctc ccctaatcgc cagaggaggg ccatcggcct
     5761 gcttgcaagg gcagttcgta cgacgtcaga cggtgccgaa gtcggcctcg cccgaacgca
     5821 ccagccccac gaacgatgac cacccggccg ggctgaactg caaggccggg ccgctcgggt
     5881 ccttggagtc gcgaacaccg accaccccgc gggcggcgat cacatcggcg atctcgacac
     5941 agctatttcc ggagccgccg ctgtacgacg acttgtacca ggcatcttcc ggtgccagct
     6001 caagggctgg gatgtgagtg ttgatggctc tacaactctc gtgctagtcg ttgcatgaat
     6061 tcgggcgtct ccctgggcgg aagcgccgtg gcgatcatct cgttgaacct acgggtgaac
     6121 cgtgccacct ccttgggctt gtccgatgtg gagaccgcac cccaagcgtt gtccacctgc
     6181 accatcggcg gcagtccgtc acccaggtcg aggatggcca agtcgctgct ggccctatac
     6241 ccctgagcgt cgatgggcag cacctggatt ttgacatgtt cgagtgagca caaccgcgtg
     6301 atttcttcgt actgctcgcg catgacgtcc gggcccccga tgagatagcg cagtcctgcc
     6361 tcgccgagga tgacccacag cttgaccggg tcgggctcgc gctccaagac ccgctgcttg
     6421 cgttccatcc gcagtgccac gttggcctga ttgaactctg tcttcgtctc ttcgatgggc
     6481 ttctcgatct cgaagatcgc ctccgcgtac gccttggtct gtagcagccc gtgcaccacc
     6541 tgcgggtggt agatccgaat ctcctgagcc tctgcctcga ttcccacgaa cccctgcatc
     6601 gcgggcagca cctggccccg gtagcgcgtc acccagtcct gactggtcgc gtcgcggttc
     6661 atctcgacga aggactcgac ggtctcctcg tcttccactc cgtacttggc cagcagcttc
     6721 ctgagatcac cgacgttgcg gaagttgagg cccccggtct cgatgcgctg gagtgcggcc
     6781 tcggagagcc tggacccctg caccgctacc ttgcgggtca tcggcttgcc gttgacgagg
     6841 atgttctcgc ggatgcctct taactgcagt cccagttcga ggcgcctacc tgtcgccccc
     6901 cgcttcgctg ccacctgtgc gcgctccctg tgttcgtgtg ccgaccttga ggtgccgtgt
     6961 gcagagtgtt gcacctcatg ctcgggtctg acagcccctt gtgcaggttc acgcatagtc
     7021 caatatcgtc tccgctgaat tttcagtgca gatgcggttg caaatgaacc cgcttacggg
     7081 ccacggtagt tgagccagga cgaacgcggg cagcgtagca agggatctga tcaaccgatc
     7141 gtacggaatc cttgcgtctt gcccttctga gctgcgaagg agtggggcat ggctgtcgct
     7201 gcactggatc cggagatcct tgaggagctg cgcaccggct gcgctacgaa cgccataccc
     7261 accgtcctcg actacctctc gctgaccctc gatagggagt acctgacggc tgacggagac
     7321 gtgccgagca cgacagcggt ttgggtcggg cgggttcgcc ggatcggcag ggccaagctc
     7381 actgtctggg gcctgtcggc cctggttgat gacgtacagc tactgatcag cgaactcgtc
     7441 acgaacggct tccggcatgg cagcggtcgg catatcacct tccggctggt gatcggcgcg
     7501 gggctgctgc tcatggaagt ggacgacggc tcatcggtgc gtccccagct tcgcgacgcc
     7561 ggcaccgact cgctcagcgg ccgtggtctc ttcctcgtgg acgccatcgc ctcgtcatgg
     7621 ggcgtcagtt cggacggcac aaggacctgg tgcaccctca atccccttga gcaggagcgg
     7681 agaagcgaat gcggagcagc gtgcttgagc gcgatccggg cgccgtccct ctgaaccacg
     7741 gaggagaagc gcaaaacgac gatcagacaa aggcgcggct tcttgccgct ctgagagcgc
     7801 ggttcctgct ggagtcgccg gagatccccg tcgtagacgt catcttcgat gacctcgagc
     7861 gcatcctcgg tgagggcgcc gccttgacgg cctcggaggt cgccagtctc accccgcgtc
     7921 tccacgcgct ctaccgacgt gctgtccgcg cgtcccggca cccgaacagc ggcgtgcgtc
     7981 ccgcgacggt cgctgcgtcc caccgtctct tattcgagcg attcccaccc gagttccttc
     8041 cggctctcgc tcaccttcgg cgccttgcct tggccgtctc ggatttgctc gatgagctgc
     8101 tggaggacat gccgtgagcc gtcgagtggc tgctcctgag cagcacgacc gcgcccgctc
     8161 tccgctggcg atcaaggtac tgcccgctcg cgaagcctac gattccgaac tcgtgaccgc
     8221 cctcctgcgc gacccgaacc tcctgctcga cagcgttgcc gtgtgcatct tccgggcgcc
     8281 ttccctcgct gtccctgtga gcgggtgcag acgtggcgga cggatcgacg cgggcccgat
     8341 gacggctgcg ctggtcgtac gcaccgcact cctcggccgg ccggggctcc cctgccccgc
     8401 gtcagcctgt ccagggtggc gtacggcgag agctggcttg tcgaatgggg agaccgggcc
     8461 ccggaccaac cggtcggcaa ccccgaacgt ctgcgcttct tcgggaactc caccggctcc
     8521 gactgcccgg agccgccgtt tcaccgtgca gccgccagcg agggtacctg tctccctctc
     8581 cgcccgctcg tcctggtccc ccgagatgag ccggtggggg aggggctgtc gatgaggaat
     8641 gacatgtgcc agcaccagcc tccgtgtccg ccagcagaag cttctgaccg cgaggccgct
     8701 cgcgccgcag cacatcatcc cgagcaggga tggacgctgc tgtgcaacgg tgtcttgatc
     8761 ttcgaggaca ccggcgagtt gctgccggac ggcaggatcg tcgcgccgca ccgcccactc
     8821 tcgaacgtgg tgggagcagc agcatgaaca cttccccgtc ttggtccgcc gccgtcccgt
     8881 acatcactgc tcgccgcggc gaggaggcgg agatcacggc catgctcggc tttcgccccg
     8941 gcggcggagg gttgtgctat ctggacgagg gccctgggga ccgggatgac cagggggtcc
     9001 tttgggctcg gtgctcacag tcccgcgagg atggctggcc ggtcggctcg ccgcgatggg
     9061 gaatggtgca tccgtcccgg cagcgcgaga cgatgcaggg cctacggtgc caggtctgca
     9121 tcgtccagcc ggccagccgc accgccagcg gctacttgtt cctctcgacg aggccgaagg
     9181 taacggggcg ggactggccg gagggagtcc ttacctggca gccgcccctt tgcctcggct
     9241 gcgccgtgat cgctgtcgag cagtgccatc acttgttgag ggccggagcc gtcgcgttgc
     9301 gggcacgcgt gccgcgcctg tacggggtaa tcggcatcct gtacaccaca gggaccgatt
     9361 tgcggccggt gcccgtgcag gtgagcgagg aggcgagaga caccccgctg ccctacaagg
     9421 accatctgct gagaccctgg ttcctcgcct cgcagctcgt acgcgagctg cgtggggtaa
     9481 cggttgtcga cctcgaacgg gagatcgcga cagcccgcct atagacggcc gcctcggcga
     9541 atcggtgggt acgaacccga ccgctggggc ggcacaagac tccgacctgg gacaggcggc
     9601 cctgcacggt ccacgtgaag ggcatggcac cccgggcgga gccgggtatc acttctgcag
     9661 cggcatggac ttcatacgct ccgtacgtag atgtccggca gacccatcgt ccgcaattct
     9721 gttagcacca agggggttcg catgagtttc cagaagacac acgccacgca ggagaagccc
     9781 caaggcttgg gcacgacgtc ggacggtttc gacctggacg tcagcctggt cgaggtctcc
     9841 gacaccgccg gtctgatcag cctgacggac gacggctgtg gcgagacctg cggcgcctgc
     9901 accaccaacg tggcctgacc tgagccgcac gtcatctagg ccggtgcctt cgcgactcac
     9961 cgtgcgaagg caccggcccg cctggaccac ggagatcgtg atggctccaa gcaccgtgta
    10021 tcgcgctggg aagaccgcac tcctgcgcgc cgtcgctcgg ccggaacttc ctgtaccccc
    10081 gtgtcccgac cttgacgact cgtccccgcg cggtgcggct gcccggctcg cctggctgcg
    10141 cgaggtctgg accgaggagg accttgccga ggctctggag cacgccagcc ctgctctcgc
    10201 ttcgcaggtg agagccctgt gctcgtccag ttccccggtc gcgcgagacg tgcggcgtgc
    10261 cgtcgcctcg gtagcgcggt acgtgctgcg tgccgaacac cgggcgacgc cgttcggcct
    10321 gttcgccggc gtcgcatcgg ccgccatcgg gcccaggacg cgcgctgtgt ggggttcgga
    10381 gcacacggtt gtcggccggg cgagtgggga gtggttgact gctgtggtcg aacggctgga
    10441 gtcatgcccc gagctgatgg aacggctctt ggtggtcgtc aacaacgcca ccgcgacacg
    10501 cgatggccgg ctcatcgtgc cgtacaagtc cgcttccgag ggagaccgcc ggcatgcgat
    10561 cgaagtatcg gtggccctga ccgggccggt gcagacagcc ctggaagcag cacgggcgcc
    10621 ggtccccgcg ggtgttctcg cggaaaatct tgctgctgag ttccccgcag cagattctgc
    10681 aaaggcgcaa cggctcgtac gagaactcgt tcagcacgag gggctgatca cgaacctgtg
    10741 tgcaccgagt acggagaccg acgcactgcg ctatctgctg agccagctcg acgcggtgag
    10801 tgctgacagc gtggcgccgg tcgctgatac ggtgcgcgaa ctgcatgccg ttcagctcga
    10861 cctcaccagt tgtggttccc gcagcggccg ggcccgcgcc gcagcgcgga tgcgggctgt
    10921 ggtcccagac ttgaagcggc accctctggc actggatctc tgcctggacg ctcaggttga
    10981 gttgccccaa gcgattgcgc aggagatcga gcgtgccgcc agtgtcctga cccgggtgag
    11041 cgcccacccg tacgggacag cggcttggaa ggcgtaccag cggcggttct acgagcggta
    11101 cggcatcggc accatggtgc cgctcggcga agtcctcgcc gacagcggta ccggctttcc
    11161 cgacgggtac ccgggcaccc ggattactga gggccgctct cgcctctccg tacgggacga
    11221 caccttagtg cggcttgctc aggccgctgt tctcgacggc cgcgacgagg tggcgctcac
    11281 cgacgacctg atctccgcga tggacgtggg gccggagtgc ccgagggtgc cgccgcacct
    11341 ggaggtcggt gtccgggtgc acgcggccag catcgaggag ctgcaccgcg gtcgcttcct
    11401 cctggagatt gcgaacgtgt cccgtggagt tggggtcacc atcggccgct tcctcggggt
    11461 cctggctccc gaggaccgcg agcggctgtc accggagctg gccgacctgc cgaccgctga
    11521 cgctggcacc attcccgcgc agttgtcgtt cccgcctctg ctgtccacga gcgcccacgt
    11581 cacgcgggct ccacaagtgc tgcccacggt gatcagcatc caggagtacc gcgacaccgg
    11641 cagcgacgtc ctgacgcccg gcgacctggc ggtggcgtgc gacgggcgcc gcatgtatct
    11701 ggcggcacca gagctgggtc ttcgcgtcga ggccgtgggg atgcacgcgc tgaacctcac
    11761 cacacacact ccgccgctcg tccgattcct cgccgagctg tcccgcgccc agtgcgcgca
    11821 ggtcaccctc ttcaactggg gtgccgcaaa cgcgatgccc ttcctgcccc ggcttcacta
    11881 cggccgcacg gtgctcgccc ccgcacggtg gcggctggac gcggccgagc tgccccgcca
    11941 cgaccgccct caagaccagt gggattccgc ccttgaggaa tggcggaccc gacggcggat
    12001 gccgctgcgg gtcgtgctgg ctgaggacga ccggcgtctg cacctcgaac ttgaccaggc
    12061 cggacaccgc aacctgctgc gccagcacct caaccgcgtc ggcctggccg tcttcgtgga
    12121 agccccagcc gccgatgcgt acggctggtc caacggccgt gcgcatgagg tcgtcctgcc
    12181 gctcaaggcg acgcgaccgc cggggtggcc cgcgctgccg acccccacac cggcccgcac
    12241 cttctccccg gagcagatcc aaacgcccgg agcctcgtcc ctgctgctga ccaccctgta
    12301 cggcgatccg cgccgtcaag acaccctgct cgcgcagcac ctcccggtcc tgcttgatcg
    12361 gcttggcggc ccaccgtggt ggttcatccg gttccgcgac ccggatcagc atgtgcgggt
    12421 gcggatcgcc ttgcctgacc ccgatgcctt cgccgcgaca gcccgcacgg tcggcatctg
    12481 ggccaatgaa ctgcgcaccg ccggcttgct gtcggacatg cgcttttcca cctcctatcg
    12541 cgaaatgggg cgttggggtt cgggggctgc ctgggacgcg gccgaggagg tgttccgctc
    12601 ggactcgcgt gccatcgtcg cccaactctc acagtcgaat cgcccgtccc agcgcgcact
    12661 ggtggcggcc cacacgatcg ccatcgccac ggcgttcctc ggcagcgtcg aggaggggat
    12721 gcactggctg atcgaacaca tcccgccagc cgcgcccacg acggtgccac gcccgcagtt
    12781 caccgaggcc gtacggctgg ccgacccgtc cggcgactgg gcagccctcc gcggcgtgcc
    12841 cggtgggcag gccatcgcgg aggcatgggc cgaccgcgac gcggcgctcg ccgcctaccg
    12901 gccgcatctc cctggtccgg acacccgggg catccgcctg gacgacgtcc tctcctcgct
    12961 cctgcacgtc cacttcgtac ggcacatcgc ggtcgacttc accgaggaag agatctgcct
    13021 ctacctcacc cgcgccgccg ccctggcctg gatgtccagg agggcgcaat gacccacccc
    13081 ctcgcgctca agacggtgga tgccgtcgcc gacctcctgg ccgacccagc taccgcaccc
    13141 acgggaccag gtgatgcgtc tctgcaccgc cagcacctcg cgtacgggcc gaccggcatt
    13201 gccctgctgc acatcgagcg ggccgccgcc ggtctggggc cgtggcagcg ggcccacgac
    13261 tggctcgccg cagccgctcg gcagccgttc accagtggcc ccgacagcca ccccttctac
    13321 ggcgcacctg ccctcgcaca cgccgtggcc tgtgccgccg accacctgac cggcgcctac
    13381 gagcgagccc gggactctct gaaccagcgg atgagcgccg acgttcgccg ccgcctggag
    13441 gccgcgcacc gtcgcatcga cacggggcgc cttccagagc tggcggagtt cgacgccatc
    13501 cgggggctgg tgggctacgg cgcctacttc ctgcgccgcg atacgaccgg tgccgacctc
    13561 cgcgccatcc tcagctactg cgtacgtctc gccgagccgg tgacctgcga cggcggagct
    13621 tgcccgggat ggtggacgcc gagcggacca tccggccgac tggacgaccg ctttccgggc
    13681 ggccacgcca acaacggaat ggcgcacggc atcggtggtg tgctcgcgct gttggccctc
    13741 gctgcccgac gcggtgtcac cgttgacggt catcgcgagg ccgcctacac catcctgacc
    13801 tggctcgacc ggtggaagga gaagactggc cgaggtgggg cgtggcctta ctgggtcacg
    13861 cgagacgagc tgcgctccgg ccgccctgat ccgtccccgc gccggcgacc gtcgtggtgc
    13921 tacggaacgg ccggcctggc ccgtgcccgg cagcttgccg ccctcgcctt cggcgacacc
    13981 gaacgccagc tcgacgcgga gaacgcgctc gtgtccgctc ttacggatcg cgggcagctc
    14041 aaggcgacca cggacagcgg attgtgccac ggcttcgccg gtctggccca catcgcggcc
    14101 cggaccgccg agggtgcgca cgcctccact gccggacagc ttcgcgcggt gatcccctcg
    14161 ctcctggctg cggtctgccc gccgggcact gttccaaagg acaaggcgga ggcggttgtc
    14221 caggccaggg cggcagggcc cgggttcctg aacggcgccg ctggtatggc gctggcgctt
    14281 ctggcccctg ccgccgacgc cccgccccga tccgcctggg acacctgcct cgtcatcgcc
    14341 tgacccaccg accgaaggac tcgccatgtc cccggaccgc tggtaccagc acaatgtcac
    14401 cttcgccgac cgcgccaccg gtaagcgggc catagccgac tgcctcggcc ctgccctgct
    14461 cgaagccgag aaagacgggc agctcaccgc ctggtggttt atgaacaagc agccttggcc
    14521 gctgcgatac cgctctgctg cgccgtcccc gctcatcgag tccgtgctga gcgatcttgt
    14581 cgacgacgga gcggtccggg cgtgggttcc tggcatctac gagccggaga ccacggcgtt
    14641 cggggggccg gagaacatgg acgccgccca cgagctgttc caccaggaca gtcgccacct
    14701 gctcacctac cggcctggac ccggacgact gggcagacgg gagaccgccg tccttctgat
    14761 cagcgcactg atgcgggctg cccgtctgga ctggttcgag cagggcgacg tgtgggccaa
    14821 ggccgccgaa ctccgaccgg cgccgcagga actggctccc gatcgggcca ccgccctggg
    14881 ccaggcggtg aagcggttga tgaccgtcga cagccgcagc ctgtgccgtc cgggcggtcc
    14941 gtttgacggt cacgatgagt gggtggccgc cttcgagcgg gccggtgcga cactcgccga
    15001 cctggctgcc cggggcggcc tcacgcgcgg cgtgcgcgcc atcgtcaccc accacctgat
    15061 cttccacgca aaccgcgcag gtctccgctc ggatgaccaa agcgccctgt tcaacatcgc
    15121 acgaaaggca gtcatgggat ccagtgacaa caccgcgtcg tccgccgagg ggacgcccga
    15181 aaccactagc gtcagggcgg tgaataccga cacgctcgcc aactccgagg ccgacgcagc
    15241 acagctccgc aacgccctgg tcgacaagat ccgcgaatcc ggctacgccc gcaccgccgc
    15301 ggtcgagacc gcgctgcgca ccgtgccccg ccacctgttc gtgcccgacg caacgctcga
    15361 agacgcgtac gccaacacgc cggtcaacgt aaaatacgac accgacggca cgtcgatctc
    15421 ctgcgcctcc cagcccggag tcgtcgcgct catgctggat cagttggacg ctcagcccgg
    15481 cgaacgcatc ctcgaactcg gtgccggcac gggctacaac gcggcgctgc tcgctcacct
    15541 cgtcggcgag acgggccatg tcaccaccat cgacgtggac gacgaccttg tggaaggcgc
    15601 ccgtgcgcac ctggctgccg ccggattcac caacgtcgag gccctgatcc gcgacggagc
    15661 ggtcggtcac gccgacggtg ctccgtacga ccggatcatc gccaccgtcg gcgcgcatgg
    15721 cgtcccgcac gcctggatgc agcagctcgt acccggtgga cgcctcgtgg ttccccagcg
    15781 cctcaagggc agcgtctccc gctccatcgc ctacgaacag cgcgacggcc gctggaccag
    15841 cgtcagcagc aaaatgaaca ccttcatgcc gctacggcgc ggcatcgccg acgacgaccg
    15901 ccgcgtcatc cctctcagca cggacggcac cgtacggctc caggcccctg ccgggcagcc
    15961 catcgacgcc caggccctgg ctggagtgct ggaccagccg cgtaccgaga agtggaccgg
    16021 catgacggtt cgcgccatgg agtcgcccga gtggatggag ctgttcgtct cctgctctgt
    16081 gcccagcggc ctgatccgga tgctgttccc cgccgacgcc aagggcacgc tgctcacgga
    16141 ggacccctac ccctcctcga ccgcggctgt cgacaagggc gccgtcacct acctcgcccg
    16201 ccgcgtgtcg gagaagaaga cccccgaggg cggcaagctg tgggagttcg gcgtcatcgg
    16261 ccacggtccc ggcggcgacg agctcgccgc gcgggtcgtg gacgccattc gcacctggga
    16321 ccgtgagtac cgcgatcgtg aagccacgtt cgagatccag cccctcgacg ccccggccat
    16381 cgagcaggtg cccggcctgt tcgccctcga cactccgctg aaccgcatcg tcgtcgactg
    16441 gcggtgactc aagctcggct gtgaagaagg tggtgcccat cgcacggccg aactgcaccc
    16501 tctcgccctc cctcatccgg gtaccgtcgc accaggggga cacatggacc cgcacggccc
    16561 gatagcaagg cgctttccgc tcgtcgcccg attccggccc gcctgctcgc cgctgcctgc
    16621 ccgcgtgcgg tccctggccg aactcgccgt caaggcaaca aaccaagatg atcagggtgt
    16681 tgcctccgcc gtcttcaacc aggccgcgct tgtcgcctct gacaccggcc tgcctgacct
    16741 cgcccggtcc atgtgccacc ggcacgccga ggcgtacctc cgggcgggcc cgctgcccgc
    16801 catgagcgcc atccgtgggc tggaacccct ggtcaacctg gcgcgcttgc agatccgcgc
    16861 cggccacaac gacgacggcc gccaacggct tctggacctg tacgaagccg tcggaacggg
    16921 ccacaccgcg gtcttcgagg gcatcactgt gccagcggac ctcacttgca cagacgagga
    16981 ccggcgggag gttcacgcct ggctgtggcg tgtggtgctc gcggacggca cgcgtagcct
    17041 caccgctcag ggccgttggc gcgaagccct gtcccatatc gagcggcacc gcggcgtggg
    17101 cacacggatg ctcgacggcc gccaggtcgc cgtggtcgcg gccctcaccg aaggccacac
    17161 cgaacgcgcc gtggaactgc tcacggggac ggcgcccggc gatgcgtggg aacaggccgt
    17221 caccgcgtgc ctgaccgcgc tgtgccgccg cgacaccggc cagaacctcg gcgacgacgc
    17281 agacgaactg gtgagcacct acttcaacca ggaggctcaa ccaggccgta ccgtcttcga
    17341 catccgcctc gggctcacag tcttggacgc ggtcggcgcc cgacatcccg cagcccacca
    17401 actcgtcgaa aacctgttcc tacggaccag ggaaacgctc gacgggtacg ctgcccgcga
    17461 agtcctggcg cacgcgctgt tcactgccct cgtttcagac aatcaggctc aggaatgccg
    17521 tgacatgctc ctgtcctgcg gcctggggac aggaatcatc gctgatgact tggccggcgc
    17581 actctcagcc gcgctcgacg ccgctgaagc cgtaatcact cgctccctga acgccgtgac
    17641 gccgaggtga gccgagcgcg cggaatccgg cctgtcgtta ctcgcggcta ctctcgaacg
    17701 catgagcgcg cctactgaag ggctgactct gggggccgtc agcgcgatcg tcgagaagaa
    17761 gatcctcacc aacaagatcc gcatctaccg gcccggcaag ccggtgttca acccggacac
    17821 ggggcagtac gaacctggac cgcccgtcac cgtctacgag ggcccgggcg cgatctttcc
    17881 aacgggcggg ccgtccgtcg tcctgcacat cgcaggtcag gcgtacgtag atgacacgcc
    17941 gtctcggtac cgtctgctga cgccgctgtc ggcgccggtc gcctcgcgcg aagacaccgt
    18001 tgccatcgtg gaagccgaag acaagtcagc tatcggccgg acgtggcgcg tgatcgacat
    18061 cggggagaca tcaacgctga gcatcgtccg taccacctgg gtggaccaga acacccagac
    18121 caccggagcg tgaagtgacg acagcgatcg atccggagga agtgcggcag gagctggagg
    18181 ccaaactctt gctcgatacc gtgcgagtca cccggcccac cggcacgccg acgctcgacc
    18241 tctcaaccgg cctccttggc gaggtacctg ccgatctggt ctacgagggg cctggcgcga
    18301 tgctgtccgg acacgggcag gtgaccgccg aggggatcat cggcaagcag tggctcgacg
    18361 acaccgtgtc ctggtaccgg ctgctgacac cgctcggggc gccggtgcct gcgcggtacg
    18421 accgggtaga agtgacggtc gcgcattcgg gcagtgccgc aaccggcggt cgtgtctggc
    18481 aggtccttga cccggccgag gcgtcgaccg tggaactggt ccgggtgacg cggttggacg
    18541 agatcacgcc gccgtcctga ggcaagtgga gtgtccgcga accgtcctac gctcggtaca
    18601 tggagatcac ggacactccg cccgccgaca ttcagcagat cagggtcacg gcggacggca
    18661 gcaaggcttc gatacagata gccggaatcg actactcgcg agtcgtctcc ggctacacca
    18721 tccaccaaca agcgggggag gccgcggatt tggtagtcca gttcgcgcag ggcaggacga
    18781 gccctgactt tgacggctac gccagggtcg cggtcggcat cccgtacgag ccggggccgg
    18841 cagccgccca cttcctttca gcgatcgacc caggactgct ggagaaggag gccctggcaa
    18901 ggccggacat gggcggcggt ccgcacggct tcaccagggc cgtactggcg cagctccagg
    18961 agtgggcgcg gggggagttc gaccaagcca aggaggcgag ctgatggcat ctccacggaa
    19021 cccacacccg aacgcgcacc cgtcggcggg ggcgtacagc aacgcgccgc agatcgcggc
    19081 tctgttgaat tcccgcgcgg cagccgtgct ccctgcggtg gccagtgtcg tccagcacta
    19141 cgccatgctc ctggagacgg ccatcaaggc caatgcgagc ggccggccgg gaccgaacgc
    19201 gccgacgggt gactaccggc ggtcgtggac ccacgagctc aacacgagcg gcctgaatat
    19261 agaggcgatc gtcggcacca acaagccgca gagcaggcgc ctggagtacg gcttcgtcgg
    19321 agccgacagc ctcggacgga tctacaacca gccgccgttt ccccacgtcg gcccagccgt
    19381 tgagcacatc cgtcccgcgt tcctggcagc cgtcggagcg gcggtgggtg actgatggcc
    19441 gtatcgggac gagtgctcag tcttgccgtt caggcgatgc tcggtactgc gaccggccga
    19501 tcctgcgggt acggcacggc gccaaccgcc agcagcttgc cgaccggcgc cgcgacgccg
    19561 tacagcgtac tctatccggt cggctccacc agcgacggac cacccttcgg cgatgcgagc
    19621 gcagatgcgc ggatcgtcta ccagatcacg tcagttgcca gcacgaccga gcaggctgag
    19681 tggatggcag acaaggtccg ggcagggatg ctggcccgca ccacactcgg ctacacctac
    19741 ccgatcaacg ctaccggcta cgtggtcatg tcccgtgagc tggacaaaga agaaggcgtg
    19801 actgtggcca gcggcgtata cagttacgtt cagcggttcg cgatcgaggt caccagcctc
    19861 ggctaactgc cgcacctcac ctcaccgcgg aggcctatcg cggacgcccg accactcggt
    19921 acgggccgac tcccagcttg atccgttggg gacgtgcctg ccgtattccc gggccgtcag
    19981 cgtccccgga gagtgagagt cgcgtggcaa ccacgcagca gcgtttcatg cgccgaggca
    20041 ccaccctctt ctacttcctg cagaagatca cctccgacgg caacatcccc actcgcgccg
    20101 aactcggtcc cagcaacgcc accaacctgt cggacaccat ctccgacgtc gaaggctggt
    20161 cgctggagaa caccccgatc gacaccccgg acatggggtc gacgttcgcc actacgattc
    20221 cgggcgagga caaggcggac aacagctcgc tgacgtttta cgaggacaag gtcagcgacg
    20281 agatcgagac cctactgtcc aagggcgtca tcggcttcat cgttatcctg cgcaagggcg
    20341 acgtacctca gtcgaagtcg atggacgtct tccccgtccg cgtcggcagc cgcagcccct
    20401 cgtacagcac cgcgagcgag cccgccaagt tcaaggtcac gttcggcatc accgacgaac
    20461 cggccctcga cgccgccgtg ccggcgaaga ccgtctgagc cgtggctgcc gcatgaccac
    20521 cacagcgata tccgaacccc cggccgccgc cgtcgcccgt gacgcccact ggtcggcgaa
    20581 gatggcgcga ctcaaggccc gccagctccc cgagcgcagt ctgcggctgt gtgacgacga
    20641 cgaagcgaag aagaacgcca ccgatgccgc cctggagctc gccaaggcgc gcacagtcgc
    20701 ccgcggccag tccatcgagc agggcgtctc ggaagccgac cgcgaggaat ggacagtcag
    20761 ccagccggaa gtcgtcgccg cgcaactgcg actggacgcc gccgaacagg tcctggagga
    20821 cgcgacgatc gtcctgacct tccgagccct tccgcgtccg gcctgggaac agctcctgcg
    20881 cgatcatccg ccgacagagg cccaggccga tcagggcatg gagtacaacg tcgagaccta
    20941 tccggcagct ctcatcgccg catgccacat cgagcgggac gagtccggtg gcgaagttcc
    21001 cgggatgagc gagcaggaag cgcaggaact tcttgacgcg tggcctgact ccgaggccaa
    21061 ggccctgttc acctgtgcgc tgctggtcaa ccagacgctg agggcggatc tgggaaaagg
    21121 ctgacctccg acccgggctt ccgagcggag atggaggtct gtgcctcgta cggcatccct
    21181 cattcgcagt tcaccggcgc gggagacggg cggtggtcgg cgctcgaccg tgcgaaggcc
    21241 atcgcgtacc tcagcctctc gcgaacggtg tgcgagtcgt gcggaaccag gccggaggag
    21301 tgggacgagc aggcgggtgg cgaccgcttc gcgtacgtca cagagacaca ccggtgtgtc
    21361 ggctgcgagc tgatcgccat ggagcaggaa caggtcccgg agggtccgga ggggcgtggg
    21421 gtgaaggtgg ggcttcggcc cagaaagaag gcttagccag tggctggggc ctacaccctc
    21481 tacgtccagg tccaggccgg cgtgactggc ctggtgggag gtctgcgaac agcggcgggc
    21541 caggtaaccg cgttcggcgg ccaggtccgc cgcctcgacg gcgacctcaa cgcgctcgcg
    21601 gcgcgatcgg atcggacccg tcgggcgatg gccaccgggt tcactgttct gggcgtcgcg
    21661 atcggcggcg cgttcgtcat gggcgtgcgc agcgccattg agcttgagaa gcgcatggcg
    21721 aacgtcatga caatctcgaa gaagatcaac agcaccaaca tcagccactt tacggaccag
    21781 atcgtcgagc tgagcaccca gctcccgcag tccgccgacc agctcgccga gggcctgtac
    21841 caggtcgtct cgaccggctt cgacggcgcc gatgcgatga cgatcctccg ggtggctgcc
    21901 cgcggcgccg ccgctggcct tacgacgacc gagacgtccg cccgagccct gctcggcgtc
    21961 ctcaaggcat acgggatgga cgcctcacag gccagcgacg tcatggacgt catgttccag
    22021 accgtcaact acggcgttgt gtcgttcacc gagctggcac agcagctcgg cgacgtcgtt
    22081 ccgatggccg ccgcggcggg tgtgaagttc gaggacatca gctcggcgct tgcagcggtc
    22141 acgctctcgg gcatcccggc agccgagggc gtcactgcgc tcaacatgct gctgacgcgc
    22201 atgatgaagc ccacccaaga gctgtcgaac atgatcagag gcttcgggta cgagtcggcc
    22261 gccgccgccc tccagcagga cggcctgtac gttgtcatgc agaaagtccg caacgccacc
    22321 ggcggcagcg cggaccagtt ggttcccctc ctgcgcgaca tccgagcggt ccgtgccgct
    22381 ctggcactct cggccgccga cggcgagaac tacgccgcga cctaccaggg catcagccag
    22441 gaggtcgagc gcgccggcgc gacgcagaag gcgtacgcga tccagatgga caccactgcg
    22501 ggccagtgga gtctgtttca gaaccaagcc caggcccttg gcatcgacat ggcgcgcgtt
    22561 ctgctgcccg ccctgcaagg tgtcggggag tacctgaatg tcctggccgg ggccatcaac
    22621 gacctaccgg gtccagtgaa gtcgatcacg ggcgctgtgc tggcgctctc ggctgcggcg
    22681 ctgctcgcca aggctgcctt cctgcggttc ggcgcccagc tcaccgtgtt ccggaccaac
    22741 ctcgcggcgg cacgagccgg gggatccgcc ctccctgcgg ttctcagcgg agcgggcatc
    22801 gccgtggccg ggttgacggc cctgatggcg atcggcatcg gggtgtacgc cgcctactcg
    22861 gccagcaaac agaaggcgaa ggccgcgacc gaggaactgg ccgacgccct gcgcaaggaa
    22921 agggaggagg gagagcaagg ggctggactg cggaccctga cggaacagct cacgaacagc
    22981 gacgacgtca agaagctgaa ggacgcaggg atcgacgtgg cgaccgccat cgacgcgatc
    23041 acgtcaggcg gcgcgaagct caagaagctc aaggacaagc tgcatttgca gaaggcgtcg
    23101 acctggaaga tcggctcgta tgcgcccgag ccggagtggg acgctgccaa ggaggtcctg
    23161 gacaagcagc acaagatctg gagcaacgcg gtcaagcagg agagccagct tgccgcgagc
    23221 atggcgatcg tcaacaacaa gatcaagaac aaccggcgcg agatgcgcgg cgcttgggat
    23281 ctcacgcagt ccctgccgac ggacaagaac gggaagccgc agttcaccga gcaaatggag
    23341 gcgatggcca agtctctcgg ctcgatcgtc gacccggcga gggcgtggaa ggccgcgcag
    23401 gacaaggtgg ccgaggccaa ccggaaagcg ggccggtcgg ccgacgcgtc gaaggcatcc
    23461 ctatcggact acgtcgcgga gctgcgcaag cagctcaagg cacagcgcga gttccagaag
    23521 aacctgggcg atctggccgc cgccggtcgc ctcggtctgg cggaccattt ctccgacctc
    23581 ggccctgact ccgcgcccat cctcgacgag ctggtcaagc agctcaagaa gggcaagggc
    23641 aaggtcgccg acgagctgga atcgatcatc cgggagtcgt ccgcccgctc gactcccgct
    23701 ttccgcgccg gcctggggca gttacccgcg atttcagcga agtacggcaa gaaggtagcc
    23761 gaagcctggg cggacgcggc agccaccaat gaccccaaaa agctcgcccg cgtcatgcgg
    23821 gacatgaccg tggccgacat ggagacggcg gcgaagaagc tgcccaaggc cgcagccgcg
    23881 cagctcgaac agggcatggg gctcctggcg gacgtatctg ccaggttcgg caaggaggcg
    23941 tccacttcgc tggcgcagtc cttcctcaag ggggacatcg gggaaatccg ctcgcagctc
    24001 aacgccctgt acggcgcgga cctgccgatc aaggcgcccg acctgacggg ggtcgtgggc
    24061 gcgttcaagg cggctggggt tcagtcgaat tccgagtggt ccgggatgct cagcctcatc
    24121 gttgccgtgg cccagcagaa gggcacggca gcggcatcgg ccctgaccac cgcactcctg
    24181 tccggtgaca tggcagcggt gcaggcccag ctcgacttca tcggtgcgtc tgtggggcgt
    24241 atccccggaa cgaagacgat caccgtgacc gtgaccaagc ccgccgcggt gaccattccg
    24301 ttctacgcca agttccagcc cagctcttgg gacaaggacg gcaatggcgt ccccgacggg
    24361 atccaggcgc caaaaaaaca ggcgaacggc ggcctgatcg acttctacgc cgatggcggc
    24421 gtgcgctccc gccgcgagga gcacacggcc cagatcgcac ccgccggcgc atggcgggtt
    24481 tgggccgagc cagagacaca gggtgaggcg tacatcccgc tggctggagc caagcgggcc
    24541 aggtccaagc ggatcttgga agaggtcgcc cgccgcttcg gcggggaggt cagttaccac
    24601 gccgacgggg gcctgtcggg cttcacctac cggccgcaga cgctgtactc cctctccgga
    24661 attgccagcg attcacagga taaaaagggg cacttcagcc tcgccctgtt cttgaagaag
    24721 ctgcactcct cggtagcgac ggccaatcga tggcgacgcg acctcaacac agtggctcgc
    24781 cgcgctggcc aggacgtggc cgacgctctg gcggagatgg gcgaggaggg cgtctcgctc
    24841 acccacaaga tggcgaccgg cagctcacgc gacgtgcggt cgatggcaaa ggacctgcgg
    24901 gaactggcca aagcgtccaa ggcgagcctc ggcgagtaca ccgggcggct ccgccaagcg
    24961 gtgaaggacc agaccggctt cgagcaggcc ttggcaaagc tcgccgccag cggtttcggc
    25021 gacctcgcca agcgcctggc cgagcagggg gaccaggacg cggccgacct cgccgctcag
    25081 gccgtgaagg acaagaagaa ggcgaaggcg gcgaacgacg ccgcacgcag cgccggcaaa
    25141 accgtcccca gcgatgatct gccggacctc gtcgcgatca tcggcgcggt caagagcaag
    25201 acgaccggcc tgcatgcggt ggccgacgcg acagggctcg acgaagacca catcatcaag
    25261 atcgccaact tgggcctctc ccgactcaaa agcgcgctgg gggcgaaggg cgccaagttc
    25321 ttctccgacc tgagccgcgc gaacaagggc ttgtcgtacg cgaacggtgg catcctcacg
    25381 cccggtctct acgcaacctc tgacggcctg atcaagttcg ccgaaccgga gacacagggt
    25441 gaggcgttca tcccgctcgg cgctgccaag cgcagcagcg ccctgtccgt cctcaacgac
    25501 gtcgccacgc gcttcggaat gcgcctggcc agcggagccg ccccaccttc cctgcggctc
    25561 gtcgacgccc ggccgccgac cgccatcaag gtcactgtcg tccagcaaca gccgaaggcc
    25621 ctcgtggaga acatgccgat caccgtccaa ggccgcgaca gctcgccgca ggagctgtcc
    25681 agggagatca tgcgccgcct gcggaacgcc cagcgtggag ggcggatctg atgctccccc
    25741 tcagcgaatg gcagatcgac ttcggcggcg tcctcatcgg ccacaagacg gtcgtgtcca
    25801 tctccgacgt cgaaggactc ggggctgccg agctgcgcac gcaggacgtc ctgaaccctg
    25861 tcgacgacgg cgcgtttccc ggagtcgatc tctacgcgcc gcgcacggtg cggatcgaag
    25921 cgggaatccg gaccgcgggc gatccggccg ccgccctgga caagctcgcc gagatagagg
    25981 ctgtcgctgc gaacccatcg atccgtcgca ccgccggcgc gctcgcacaa ctacgactgc
    26041 gctggcctgg acgtggcacg aaggtcctct tcggccgcat tcgacgcgcc gaagcggttt
    26101 ccacctccca ggccatccac ggctggatac ccctggacct ggagttcacc gccctcgacc
    26161 cgcgcctgca cgacgacgag gtgtccagcg tcacgctgcc tctggacatc tccaacacca
    26221 ccgaaggttt cacggccccg atcgtcgccc ccatcaccac cggcatcgcc accccggaga
    26281 ccagaccggg ctgggtgatc aacgacggca ccaccggtgc gtggccgacc atccggatct
    26341 ccggaccggt caccaacccg cgcatcctgc acgtcgactc cgggcgggtc ctgaacctcg
    26401 acgtcactct cggggtcggc gagcgcatcg acatcgagac ccggccc
//
