LOCUS       NZ_JAKRKC020000003     22621 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Actinomadura luzonensis strain ATCC 31491 Contig00007, whole genome
            shotgun sequence.
ACCESSION   NZ_JAKRKC020000003
VERSION     NZ_JAKRKC020000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura luzonensis
  ORGANISM  Actinomadura luzonensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 1167817)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Genome draft of Actinomadura sp. ATCC 31491
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1167817)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
REFERENCE   3  (bases 1 to 1167817)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. v1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 89.6x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022664455.2-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 18:46:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,232
            CDSs (total)                      :: 10,155
            Genes (coding)                    :: 10,004
            CDSs (with protein)               :: 10,004
            Genes (RNA)                       :: 77
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 151
            CDSs (without protein)            :: 151
            Pseudo Genes (ambiguous residues) :: 0 of 151
            Pseudo Genes (frameshifted)       :: 36 of 151
            Pseudo Genes (incomplete)         :: 126 of 151
            Pseudo Genes (internal stop)      :: 3 of 151
            Pseudo Genes (multiple problems)  :: 14 of 151
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:31:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 821505
            Orig. end                         :: 844126
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAKRKC020000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22621
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22621
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22621
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12621](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12621)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            1081..1581
                     /locus_tag="MF672_RS48880"
                     /old_locus_tag="MF672_048880"
     CDS             1081..1581
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546654.1"
                     /locus_tag="MF672_RS48880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048880"
                     /product="hypothetical protein"
                     /protein_id="WP_242373151.1"
                     /transl_table=11
                     /translation="MRTPMTEALIRHFRDLRDGVHGRAAAREDKERLFATAVELLDPVA
                     RRVLAEFDADLLLGTGEVVASGLTRSKEGGLNAMWSLTWPEQRAAQVQPIAVVAHYGAG
                     FHHPHLRGNTVGDWPLNVFDPADADAQIDTLRVIAAGDAHNLVFQESYRLMPALTHPTP
                     TRP"
     gene            complement(1748..3157)
                     /locus_tag="MF672_RS48885"
                     /old_locus_tag="MF672_048885"
     CDS             complement(1748..3157)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012888442.1"
                     /locus_tag="MF672_RS48885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048885"
                     /product="NAD-dependent malic enzyme"
                     /protein_id="WP_242373150.1"
                     /transl_table=11
                     /translation="MATVPSVSYSITVRLEVPAGGKAVSQLTHAVESAGGVVTALDVTN
                     AGHEKLRIDVTCAARDTDHAQAIVDQLEAVEGVVIHKVSDRTFLMHLGGKIEMKSKVPL
                     RNRDELSMAYTPGVARVSMAIARNKEDARRLTIKRNSVAVVTDGSAVLGLGNIGPEAAL
                     PVMEGKAALFKRFAGIDAWPICLDTQDVDEIVRTVQVIAPGFGGINLEDIGAPRCFEVE
                     RRLRELLDIPVFHDDQHGTAICVLAALQNALRVVGKSLENVKITMAGAGAAGNAVLRLL
                     LAAGARNVVVCDYLGAVHKGRDDLDDSLRWIADHTNAEGYAGDLRGALKGADVFVGVSA
                     PGILTGDDIATMAKDAVVFALANPEPEVSPDDAREHATVVATGRSDYPNQINNVLAFPG
                     VFRGLLDAQAAGVTQEMLLAAAGALAAVVTPEELGPNYIIPSVFHPDVAGAVAAAVRES
                     AGGRARGFTEA"
     gene            complement(3214..3843)
                     /locus_tag="MF672_RS48890"
                     /old_locus_tag="MF672_048890"
     CDS             complement(3214..3843)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546656.1"
                     /locus_tag="MF672_RS48890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048890"
                     /product="AAA family ATPase"
                     /protein_id="WP_242373149.1"
                     /transl_table=11
                     /translation="MRVVTISATYGTAGSQIGPAVAERLGVPFVDRAIPSAVAQELGCT
                     LEEALACDDRAERGLGRLLSGALRLPTVTFGGVDMYVPGAMPLAPEEYVRRAEHLMRET
                     ARAQGGVFLGRAGALVLADHPGALHVRLDAPLKRRVRQTATLAETDEREARRVIDDNDR
                     ARAAYWRHFYRADPADPCHYHLVVDSTTIPVPVCVDLIVSASAALD"
     gene            complement(3853..4788)
                     /locus_tag="MF672_RS48895"
                     /old_locus_tag="MF672_048895"
     CDS             complement(3853..4788)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546657.1"
                     /locus_tag="MF672_RS48895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048895"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_242373148.1"
                     /transl_table=11
                     /translation="MADFSRPGSLYGAIDLGARKQALEAQARREAAGPQAASASVVEVT
                     EETFTTDVVDRSMQVPVVLDLWSPRAPASAQLGPVLEKVVGDLGGRAVLARVNVDASPQ
                     IAAALRVQAVPTVLAIFQGQAVTGFQQVLPEQEVRRWLDELMAAVEQFYQANPGARPPG
                     AEGEEEGPAGPPADPDLAAAEEAVERGDLDAAAAAYQRLLARAPGNEDAKMGLAGVTLI
                     KRTEGVDPADVERRLGDPADLDAHLLAADLEMLSGQVDEAFARVIAVVKRTSGDDRDRA
                     RKHLLGLFDTLPSDDPSLAKARRALASALF"
     gene            complement(4772..5323)
                     /locus_tag="MF672_RS48900"
                     /old_locus_tag="MF672_048900"
     CDS             complement(4772..5323)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546658.1"
                     /locus_tag="MF672_RS48900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048900"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_242373147.1"
                     /transl_table=11
                     /translation="MSQPKPLNLPFDPIDRAAESWRAHFGPSAAMAAVTSIMRAHQILL
                     SHLDALLKPYGLTFARYEALVLLTFSRTGALPLSKIGERLMVHPTSVTNTVDRLEKSGY
                     VRRLPNPRDGRGVLAEITDSGRDVVRHATRDLMAAEFGLSMYAEDELHAMFDQLRTLRV
                     AAGDFDCPPMRQDEGHGGLL"
     misc_feature    complement(5362..5375)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.11"
                     /tool="antismash"
     misc_feature    5414..5427
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.57"
                     /tool="antismash"
     gene            5553..7091
                     /locus_tag="MF672_RS48905"
                     /old_locus_tag="MF672_048905"
     CDS             5553..7091
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131176.1"
                     /locus_tag="MF672_RS48905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048905"
                     /product="hypothetical protein"
                     /protein_id="WP_247815807.1"
                     /transl_table=11
                     /translation="MREHAGVSREELKQSAAVTVAVLLAVGLIAAWNVLIPGVDAWENI
                     VAAVIGSLRLTGPVAAAFAAWVALRKRRALRGRSLTTWRALKAPLAIVVVVLGSFGATV
                     LVLAVKTVLTDQAGRLSLPGLGMGMAGLALYSVIGWVAGWVAPKPFTPPLAGLACYGAF
                     SWLADDRGWADKLAPGTGEPYDLFQALSGAAFFDQTIWLLGLTAALLLGWAALVTRQAL
                     VLACALLAVLAAGMGVSRVLAQTRPAAAEDIAYACQDWPITVCVHPGMRAGLTELGAVF
                     TQIAMRLDGTPAAFKRVEQRPLEEKLRPSLGLAPIHVPDLSAGFAEKAAYEYIESLSSP
                     CPGTVAEGYREIVMVWLRGEPPAGGPLAEHQYATSWFSWLNEHQRREWLRMFYNDFQNC
                     RLSSTHFGGAPARPQLVPQSVQPSPDSTHVYPVYPDPPAAPPASYVTPGYVTPDAPALG
                     YVPAPAPGWVAAAPPARPAGPRRAGPRHGADRLAQAGRPAQPAHGRGPARPAQA"
     gene            7165..7836
                     /locus_tag="MF672_RS48910"
                     /old_locus_tag="MF672_048910"
     CDS             7165..7836
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546659.1"
                     /locus_tag="MF672_RS48910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048910"
                     /product="DUF4230 domain-containing protein"
                     /protein_id="WP_242384001.1"
                     /transl_table=11
                     /translation="MTTSRTAPPEVVTGRRRRWRYAAGLLVLAVLLVVAGRLAWTWLDP
                     TGERTVDRSQPVLLQSIKDLSRFEAATGTFQVVVDLEKDANFLPDAVKGTRTLFVGAGG
                     VDAYVDFGALATNAVTVSEDRTEATIRLPHAQLEKPNLDNSRSYVFAQQRGLFDRVSDF
                     LSGSPGDQRELYLLAEKKITEAAVASDLRARADANTKAMMTGLLKSLGFTKVTVKFTDE
                     P"
     misc_feature    7237..7239
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    7974..7992
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.71"
                     /tool="antismash"
     gene            8022..8174
                     /locus_tag="MF672_RS48915"
                     /old_locus_tag="MF672_048915"
     CDS             8022..8174
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546660.1"
                     /locus_tag="MF672_RS48915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048915"
                     /product="hypothetical protein"
                     /protein_id="WP_242384000.1"
                     /transl_table=11
                     /translation="MNAELEYSIMQHHASELRRAAAEQRRVREALRSSRADRRHRSVFA
                     RFLAS"
     misc_feature    8032..8050
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.0"
                     /tool="antismash"
     gene            complement(8341..9312)
                     /locus_tag="MF672_RS48920"
                     /old_locus_tag="MF672_048920"
     CDS             complement(8341..9312)
                     /NRPS_PKS="Domain: PKS_ER (16-321). E-value: 1.4e-44.
                     Score: 144.4. Matches aSDomain:
                     nrpspksdomains_MF672_RS48920_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546661.1"
                     /locus_tag="MF672_RS48920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048920"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_242383999.1"
                     /sec_met_domain="ADH_N (E-value: 5.1e-06, bitscore: 22.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 5.2e-16, bitscore:
                     54.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAITRQAYGSADVLGLGEVAEPVPGDDEVVLRVRAAGVDQGVWH
                     VLTGLPYVMRLGTGLRGPKSPFVGTDVAGEVRAVGAGVTAYKPGDRVFGTCGAAYAEYA
                     CAPAGRLVPMPANLSYEQAAAIPTAGMTALRALREAGRVRPGQRVLVIGAGGGVGTFAV
                     QLAAHFGAHVTGVCSGSKAELVRSLGAEDVVDYTREDFADGRRPRYDLILDTAGLRPLS
                     HLRRALTPRGTFVIVGGEGGGRWLAGLDRQLRTVLLGPFTRQRPRVVFAFPREADLRTL
                     AELAGDGRIKAVVSGTYPLEQVPEAIRELEKGHVHGKLVITL"
     aSDomain        complement(8350..9264)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MF672_RS48920_PKS_ER.1"
                     /evalue="1.40E-44"
                     /label="MF672_RS48920_PKS_ER.1"
                     /locus_tag="MF672_RS48920"
                     /protein_end="321"
                     /protein_start="16"
                     /score="144.4"
                     /tool="antismash"
                     /translation="LGEVAEPVPGDDEVVLRVRAAGVDQGVWHVLTGLPYVMRLGTGLR
                     GPKSPFVGTDVAGEVRAVGAGVTAYKPGDRVFGTCGAAYAEYACAPAGRLVPMPANLSY
                     EQAAAIPTAGMTALRALREAGRVRPGQRVLVIGAGGGVGTFAVQLAAHFGAHVTGVCSG
                     SKAELVRSLGAEDVVDYTREDFADGRRPRYDLILDTAGLRPLSHLRRALTPRGTFVIVG
                     GEGGGRWLAGLDRQLRTVLLGPFTRQRPRVVFAFPREADLRTLAELAGDGRIKAVVSGT
                     YPLEQVPEAIRELEKGHVHGKLVI"
     CDS_motif       complement(8815..8877)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MF672_RS48920_0001"
                     /evalue="2.70E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="MF672_RS48920"
                     /protein_end="166"
                     /protein_start="145"
                     /score="16.8"
                     /tool="antismash"
                     /translation="GQRVLVIGAGGGVGTFAVQLA"
     misc_feature    complement(9217..9219)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(9309..9536)
                     /locus_tag="MF672_RS48925"
                     /old_locus_tag="MF672_048925"
     CDS             complement(9309..9536)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546662.1"
                     /locus_tag="MF672_RS48925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048925"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_242383998.1"
                     /transl_table=11
                     /translation="MVKPTKVTNSIRALRFAHGEMTQAELADRVGVTRQTIIAIEQGRY
                     SPSLEMAFQIARAFGVPLDDVFQYPDGENR"
     gene            complement(9530..9958)
                     /locus_tag="MF672_RS48930"
                     /old_locus_tag="MF672_048930"
     CDS             complement(9530..9958)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890617.1"
                     /locus_tag="MF672_RS48930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048930"
                     /product="hypothetical protein"
                     /protein_id="WP_242383997.1"
                     /transl_table=11
                     /translation="MPPEEKRAWIMVVVSVLAYGAYLATILGRAGSVPLAEVPYVVPLL
                     WSVGGACAASIVAFIAVSLLSPADIGSKDQRDREIHRYGEYAGQWFLVAGALAALVMAM
                     AEIPHFWIANVLYLGFVLSAVLGSTLKIVAYRRGMPGW"
     misc_feature    complement(9981..9999)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 20.23"
                     /tool="antismash"
     misc_feature    9989..10004
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.16"
                     /tool="antismash"
     misc_feature    9992..10005
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.21"
                     /tool="antismash"
     misc_feature    9994..10003
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.77"
                     /tool="antismash"
     gene            complement(10001..11140)
                     /locus_tag="MF672_RS48935"
                     /old_locus_tag="MF672_048935"
     CDS             complement(10001..11140)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="MF672_RS48935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048935"
                     /product="terpene synthase family protein"
                     /protein_id="WP_247815808.1"
                     /sec_met_domain="T1TS (E-value: 3.5e-64, bitscore: 213.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDLALPWTVRVNPHWAGAQRAAGEWAREMGMVGGPGAVWTPGRF
                     EAMRFAGWCAMAAPDAAPDRLELVALWFTWALAVDDFFIAGYKARDDLAGAGRFVEGLA
                     RFMPLPGGTAGGTAGGTAGGTAGGTAGGPRTGGHVERGLADLWARTVPLLPPGRRPALR
                     EDVLRFAAGNLWEMAHSVRRRVPDPVDYLVRSRAAKGVSGLGARLMALALGLEPPERLL
                     AGRAARELVNACADHVCLVNDIVSYSLEREVERHSNNGVVAVQDFLGCGLQQAVDVLGD
                     QLATCLRVFETLAAEEPAAGLGERDGPAYVRGLRDLMGGNLAWHLGNSRYVDLDHASVP
                     LPPGPRRAVHDSAAPAPSEPSTAGSSSGPFGTPSTTCAM"
     gene            complement(11104..12621)
                     /locus_tag="MF672_RS48940"
                     /old_locus_tag="MF672_048940"
     CDS             complement(11104..12621)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="MF672_RS48940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048940"
                     /product="terpene synthase family protein"
                     /protein_id="WP_247815809.1"
                     /sec_met_domain="T1TS (E-value: 1.2e-36, bitscore: 123.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSQPSANPTPDPPAPAHQRSRAWAQEQGLLETWDETRFESLALS
                     SKAGHCHPGANAEELELAADWYVWAAWLDDHFFGTYRGERRQAGRFLDRLARLVPEEAD
                     ERPPSPSGPGERALAELWARTARLDEARYPTSGAWRRRFADSTRSLVRGRLRLLDGLAA
                     GRAPNPLEYVAAWRSCGGAAWAAVLVERVGGAELPEAVVEARAVRAVQDAFADGVHLLG
                     DLRGHAAGEPAWGPGWNAVAVFERFLRCDARTAAERVDRLRLSRLRRFEHAALAGIPLL
                     AEAARLGTGERDRLCRYVAALRDWQTGHATWHPTPPPDASAHRWRPTRARVTGGPASGD
                     PASGGPASGGPASGGPASGGPASGGPASGGPASGGPASGGPRRATPHRASGRRVAGRMA
                     SGHRASGRRVAGRMASGHRASGRRMAGHWTSGGNSSSGRLSRGRRTSGHSTGGDLTGGP
                     LTSSHLTGSHLASGHRASGQWAGGRWGSIRRGIRSGCRISRCPGPSG"
     gene            12755..13102
                     /locus_tag="MF672_RS48945"
                     /old_locus_tag="MF672_048945"
     CDS             12755..13102
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MF672_RS48945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MF672_048945"
                     /product="hypothetical protein"
                     /protein_id="WP_242383558.1"
                     /transl_table=11
                     /translation="MRKRRLVWTGAAVTVAALAGLGVYFARVGLDAADKLSSVIGVFAA
                     LIGLALAGYGALPARAARAAGEAAEDEAPSVTASGTRSVAVGGDNSGVISTGDAARVHL
                     ASDDPPEDAGP"
     gene            complement(13143..14342)
                     /locus_tag="MF672_RS48950"
                     /old_locus_tag="MF672_048950"
     CDS             complement(13143..14342)
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131174.1"
                     /locus_tag="MF672_RS48950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048950"
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_242383559.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 7.5e-07, bitscore:
                     25.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGSVSGSVIVAGARTPIGKLLGALSGLPAVELGGIAIKAALERA
                     GVAPESVEYVIMGQVLQAGAGQIPSRQAAVKAGIPMTVPSITINKVCLSGLDAIALADQ
                     LIRAGEFDIVVAGGMESMTNAPHLLPGLRKGVKYGGSDVVDSMAHDGLFCAFDQCAMGE
                     STERYNARLGIGREEQDALSARSHQLAAAAVKNGVFDDEIVPVPIPQRRGEPVLVKEDE
                     GVRGDTTVETLAKLRPAFAADGTITAGSASQISDGACAVVVMSRAKAEELGLPWLAEIG
                     RHGNVAGPDASLQSQPANAIKQAMAKQGVTAADLDLVEINEAFASVVLQSAKELGVPLD
                     KVNVNGGGIALGHPIGASGARIVLTLAHELRRRGGGLGAAGLCGGGGQGDALLISVPKR
                     "
     gene            14428..14859
                     /gene="mce"
                     /locus_tag="MF672_RS48955"
                     /old_locus_tag="MF672_048955"
     CDS             14428..14859
                     /EC_number="5.1.99.1"
                     /codon_start=1
                     /gene="mce"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546666.1"
                     /locus_tag="MF672_RS48955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048955"
                     /product="methylmalonyl-CoA epimerase"
                     /protein_id="WP_242383560.1"
                     /transl_table=11
                     /translation="MFMRIDHIGIACRDLEEKIRLFSETFELTVVAREVNEEQGVKEAM
                     LHIADGEGGGSYIQLLEPLSEDSPVGKFLARRGEGVHHVAFGVRDVTETMAKIGAKGVR
                     LLDERPRHGSMDSRIAFLHPKDVGGMLTELVQAADPDKS"
     gene            15045..16334
                     /locus_tag="MF672_RS48960"
                     /old_locus_tag="MF672_048960"
     CDS             15045..16334
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546667.1"
                     /locus_tag="MF672_RS48960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048960"
                     /product="DivIVA domain-containing protein"
                     /protein_id="WP_242383561.1"
                     /transl_table=11
                     /translation="MQSDIDAQLNNFFEDAPAREFDVVLRGYDRHQVHDHLKQLDQELR
                     QAREQITGLQRDLSDSQRQLQEQERPTYSGLGARIEQLLRLAEEQATELVQAARSEANE
                     IKAAAKVEAADLRAAAEAEAAEKRAQATRESDEMRTAAERDAEEIRGTARREADELTNT
                     TEREVAKLRATADHEVAEKRADAEREIAKLRTTTEREVAQLRASTKRERDEVLTTAKRQ
                     ADEMRAQAQRVLEESEAKRAQDEAEFEIQLASRREEAERQEAERHATAQAATQKLVAEA
                     EQRAATAESRATKATQQAEQTRREADLHAKQLVANARKSSESIVAEAKSSAETIVTEAK
                     NEAERTRTAMQRQVDELTRQRDSITSHLAQLRQLLGGAALPGMDPEPAVTAAPPKPAIP
                     APAPVAEAPPTTPAPKVEAKSDDDAEWWQE"
     misc_feature    complement(15094..15109)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.2"
                     /tool="antismash"
     gene            16499..17677
                     /locus_tag="MF672_RS48965"
                     /old_locus_tag="MF672_048965"
     CDS             16499..17677
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:1905887 - autoinducer AI-2 transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546668.1"
                     /locus_tag="MF672_RS48965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048965"
                     /product="AI-2E family transporter"
                     /protein_id="WP_242383562.1"
                     /transl_table=11
                     /translation="MSANAETDVEDAAGAAAEAEAKAEAGAEATGAEAEATGADATERQ
                     PYGLPGKPLARGPFLFGLVGGLGVLTAIAIAQMVVNSLSTIILVVVAMFLAVGLNPAVE
                     ALQRRGLARRAAITIVFAGVIVTFALFGLAVVPPVGKELADFVAAVPGYLDELSSHPTL
                     KQLDADYQILPQLAQFVTTTLGPSLATGIMGASLVVLDGVFTTVTLLVLMLYFLGSLHT
                     IKAYLLKLVPASRRARTGAISEEILAGIGGYVAGNVLISVIAGVLTWIFLSVAGVKYAL
                     ALALVVALTDLIPLVGATIGAVVVTAVALLQSVPAGIACAVFFLVYQQVENYLIYPRVM
                     KRSVDVTPAVTVIAALFGGALLGIVGALLAIPVAAAIALIIREVVIPRQARA"
     gene            complement(17709..18452)
                     /locus_tag="MF672_RS48970"
                     /old_locus_tag="MF672_048970"
     CDS             complement(17709..18452)
                     /NRPS_PKS="Domain: Abhydrolase_1 (1-225). E-value: 3.7e-27.
                     Score: 87.4. Matches aSDomain:
                     nrpspksdomains_MF672_RS48970_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546669.1"
                     /locus_tag="MF672_RS48970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048970"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_308210683.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.4e-24, bitscore:
                     81.4, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4.4e-17, bitscore: 58.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLHAFPLSSAMWLAQREGLRKVCRVITPDLRGFGGSRLGDDEPS
                     LDLMADDVARLLDDEGVDRAVVGGLSMGGYVTLAFCRRHPDRLLGAVLADTKAVPDPAP
                     ARANRERIAQAVLSEGSDVLVSEVLPALIGPTTKERRAMVFGRVKGLVQSAPPGAVAWA
                     QRAMAARPDSSDTLAALKVPLLVVVGEEDELTPPAEAKAMAEAAPGGRLEVIPKAGHLS
                     AVEQPEAFNAAVSEFLHAELGVARS"
     aSDomain        complement(17778..18449)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MF672_RS48970_Abhydrolase_1.1"
                     /evalue="3.70E-27"
                     /label="MF672_RS48970_Abhydrolase_1.1"
                     /locus_tag="MF672_RS48970"
                     /protein_end="225"
                     /protein_start="1"
                     /score="87.4"
                     /tool="antismash"
                     /translation="LLHAFPLSSAMWLAQREGLRKVCRVITPDLRGFGGSRLGDDEPSL
                     DLMADDVARLLDDEGVDRAVVGGLSMGGYVTLAFCRRHPDRLLGAVLADTKAVPDPAPA
                     RANRERIAQAVLSEGSDVLVSEVLPALIGPTTKERRAMVFGRVKGLVQSAPPGAVAWAQ
                     RAMAARPDSSDTLAALKVPLLVVVGEEDELTPPAEAKAMAEAAPGGRLEVIPKAGHLSA
                     VE"
     gene            complement(18583..19341)
                     /locus_tag="MF672_RS48975"
                     /old_locus_tag="MF672_048975"
     CDS             complement(18583..19341)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (11-170). E-value: 5.4e-10.
                     Score: 31.4. Matches aSDomain:
                     nrpspksdomains_MF672_RS48975_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546670.1"
                     /locus_tag="MF672_RS48975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_048975"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_242383564.1"
                     /sec_met_domain="adh_short (E-value: 7e-36, bitscore:
                     119.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.3e-30, bitscore:
                     103.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGAFDLSGKQALVTGASKGIGRAVALAYAAAGADVALVSRSAETL
                     AEVAKEIEALGRRAVVLPADLTDREAAAGAVAAAVDGLGHLDIVVNNAGGSNFMVEFKD
                     LRLSGWDKIMRLNLDSAMAVCHAVAPHLLERGSGSVINVASVAALGAPFLAPYAAAKAG
                     VVALTKTLAVEWAAAGVRVNALCPGWTATELNRNLWDDESGGAATVAAVPMRRWGTVEE
                     MAQPAIFLASEASAYMTGQVLFVDGGATAI"
     aSDomain        complement(18832..19308)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MF672_RS48975_PKS_KR.1"
                     /evalue="5.40E-10"
                     /label="MF672_RS48975_PKS_KR.1"
                     /locus_tag="MF672_RS48975"
                     /protein_end="170"
                     /protein_start="11"
                     /score="31.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LVTGASKGIGRAVALAYAAAGADVALVSRSAETLAEVAKEIEALG
                     RRAVVLPADLTDREAAAGAVAAAVDGLGHLDIVVNNAGGSNFMVEFKDLRLSGWDKIMR
                     LNLDSAMAVCHAVAPHLLERGSGSVINVASVAALGAPFLAPYAAAKAGVVALTKT"
     CDS_motif       complement(19219..19308)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MF672_RS48975_0001"
                     /evalue="1.90E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="MF672_RS48975"
                     /protein_end="41"
                     /protein_start="11"
                     /score="17.3"
                     /tool="antismash"
                     /translation="LVTGASKGIGRAVALAYAAAGADVALVSRS"
     misc_feature    complement(20296..20309)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.74"
                     /tool="antismash"
     misc_feature    complement(20752..20767)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     misc_feature    complement(21597..21611)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    21754..21767
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.84"
                     /tool="antismash"
     misc_feature    complement(22528..22543)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.02"
                     /tool="antismash"
ORIGIN
        1 cgaccgtgct caaccacgcc gaggtcgtgg gcctccgcac caccggcggc acggtgaccg
       61 gcgccgagct gcgcgaccgg ctggccggcg ccgagttcgg ggtggacgcc cggctcgtgc
      121 tcaacgccac cggcccctgg gtcgaccacc tgcggcgcat ggaggacccg ggcgcggccc
      181 ccagcatccg cctgtccaag ggcgcccacc tggtgctgcg ccggcacgag ccgtggaagg
      241 cggcgctgac cacccccatc gacaagtacc gggtgtcgtt cgccatcccg tgggaggacc
      301 acctgctgct cggcaccacc gacgaggcgt acgagggcga cccggccgcg gtgcgcccga
      361 ccgaggccga catcgcccag atcctcgacg aggcggggca cgcggtccgc gacgagcagc
      421 tccgccgcga ggacatcacc tacgccttcg ccggcctgcg ggtgctgccc ggcggtcccg
      481 gcgaggtggc ggcggccaag cgggagaccg tgctgagccg cggcaagggc ggcatgctgt
      541 cggtggcggg cggcaagtgg accacctacc ggcacatcgg caggaccgtc ttcgacaccc
      601 tcgcccacct gcccggccgg ccgctcggcg acgacctggc cgacatcctg cccgccgtgc
      661 cgctgcccgg cctggccagc cccgacgcgg tcgccctgcg cctctacacc gaccgcgagc
      721 gcgaggcccg catggacccg ctggtggcca ggcacctcgc cacgcactac ggctcgatcg
      781 cgttcgacct ggtgcggctc atccgcgagg acccggcgct gggcgagcgc atccaccccg
      841 aggggcccga catctgggcg caggccgtct acgcccgcga ccacgagtgg gccgccacgg
      901 tcgacgacgt cgtacgccgc cgcaccacgc tcaccgtgcg cggcctcgac accccggagg
      961 tccgcaccag gatcgccgag ctgctgggct gagacggcca ggagccgccc cgtggccgcc
     1021 tgacccgctc cgggccgccg cggcaggtgg gcccgccgcc tgacggggca gggggcaggc
     1081 atgcgcactc ccatgaccga agccctgatc cgccacttcc gcgacctgcg cgacggcgtc
     1141 cacggccggg ccgccgcgcg ggaggacaag gagcgcctgt tcgccacggc ggtcgagctg
     1201 ctcgaccccg tggcgcggcg ggtgctcgcc gagttcgacg ccgacctgct gctcgggacg
     1261 ggtgaggtgg tggcgagcgg actcacccgt tcgaaggagg gcggcctcaa cgccatgtgg
     1321 tcgctgacct ggcccgagca gcgggccgcc caggtgcagc cgatcgccgt cgtcgcccac
     1381 tatggggccg gcttccacca cccgcacctg cgtggcaaca cggtgggcga ctggccgctg
     1441 aacgtcttcg accccgccga cgccgacgcc cagatcgaca cgctgcgggt gatcgccgcc
     1501 ggggacgccc acaacctggt cttccaggag tcctaccgcc tcatgcccgc cctcacccac
     1561 cccaccccca cccggccctg actcccgcgc acgccaccgg ggcgccctgg ctctcgatcc
     1621 agtggcgggc gcgcgtgctc gggacctgcg ctcacccggt cgagggcacg gtgaccccga
     1681 cgaccgaacc ggacgaccga accggacggc ccagccgggc aaccggccgc gggatgggcc
     1741 cggtgggtca ggcctcggtg aagccgcggg cgcggccgcc ggcggattcg cggaccgccg
     1801 ccgccaccgc ccccgccacg tccgggtgga acacgctcgg gatgatgtag ttgggcccca
     1861 gctcctcggg cgtgaccacg gcggccagcg ctccggccgc ggcaagcagc atctcctgcg
     1921 tcaccccggc ggcctgcgcg tcgagcaggc cgcggaagac gccggggaag gccagcacgt
     1981 tgttgatctg gttggggtag tcggagcgcc cggtggcgac gaccgtggcg tgctcgcggg
     2041 cgtcgtcggg cgacacctcg ggctccgggt tggccagcgc gaacaccacc gcgtccttgg
     2101 ccatggtggc gatgtcgtcg ccggtcagga tgccgggcgc ggacacgccg acgaagacgt
     2161 cggcgccctt gagcgcgccg cgcaggtcgc cggcgtagcc ctcggcgttg gtgtggtcgg
     2221 cgatccagcg cagcgagtcg tcgaggtcgt cgcggccctt gtgcacggcg cccaggtagt
     2281 cgcagacgac gacgttgcgc gccccggcgg cgagcagcag ccgcagcacg gcgttgccgg
     2341 ccgcgccggc ccccgccatc gtgatcttga cgttctccag gctcttgccg accacgcgca
     2401 gcgcgttctg cagcgccgcc agcacgcaga tcgcggtgcc gtgctggtcg tcgtggaaga
     2461 ccgggatgtc gagcagctcg cgcagccgcc gctccacctc gaagcagcgc ggcgcgccga
     2521 tgtcctccag gttgatgccg ccgaagccgg gcgcgatgac ctggacggtg cgcacgatct
     2581 cgtcgacgtc ctgggtgtcg aggcagatgg gccaggcgtc gatgccggcg aagcgtttga
     2641 acagcgccgc cttgccctcc atgacgggca gcgccgcctc gggcccgatg ttgccgagcc
     2701 cgagcacggc cgagccgtcg gtgacgacgg ccacgctgtt gcgcttgatg gtgagccggc
     2761 gcgcgtcctc cttgttgcgc gcgatcgcca tcgacacgcg cgccacgccc ggcgtgtacg
     2821 ccatggacag ctcgtcgcgg ttgcgcagcg gcaccttcga cttcatctcg atcttgccgc
     2881 cgaggtgcat gaggaacgtg cggtcggaca ccttgtggat gacgacgccc tcgaccgctt
     2941 cgagctggtc gacgatggcc tgggcgtggt cggtgtcgcg ggcggcgcag gtgacgtcga
     3001 tgcggagctt ctcgtggccg gcgttggtga cgtcgagggc ggtcaccacg cctccggccg
     3061 actctacggc gtgggtgagc tggctgacgg ccttgccgcc tgcgggcacc tcgagacgca
     3121 cggtgatgga gtacgacaca ctcgggacgg tggccacgtc aatcgctcct tcgggactga
     3181 ccaagaagtc ctcccatgtt agggggcgtt gggtcaatcg agtgccgccg aggccgagac
     3241 gatcaggtcg acgcagaccg gtacggggat cgtggtgctg tcgacgacca ggtggtagtg
     3301 gcacggatcg gccgggtccg cccggtagaa gtggcgccag taggcggcgc gggcgcggtc
     3361 gttgtcgtcg atgacgcgcc gggcctcgcg ctcgtcggtc tcggcgagcg tggccgtctg
     3421 ccgcacccgc cgcttgagcg gcgcgtcgag ccgcacgtgc agcgctcctg ggtggtcggc
     3481 gagcaccagg gcgccggccc ggcccaggaa gacgccgccc tgggcgcggg cggtctcgcg
     3541 catgaggtgc tcggcgcggc ggacgtactc ctcgggcgcg agcggcatcg cgcccggcac
     3601 gtacatgtcg acgccgccga aggtgacggt gggcagccgc agggcccccg acaggagccg
     3661 gccgagcccg cgctcggcgc ggtcgtcgca ggccagcgcc tcctccaggg tgcagccgag
     3721 ctcctgggcg acggcgctcg ggatcgcgcg gtcgacgaag ggcacgccca gccgctcggc
     3781 cacggccggg ccgatctggc tgccggccgt gccgtacgtc gccgagatgg tgacgacccg
     3841 catagctcca ggttagaaca gggcgctcgc cagcgctctg cgcgctttcg ccagggaagg
     3901 gtcatcgctc ggcaaggtgt cgaacaggcc cagcaggtgc ttcctggcgc ggtcgcggtc
     3961 gtcgcccgag gtgcgcttga ccacggcgat gacgcgcgcg aacgcctcgt cgacctggcc
     4021 ggacaacatc tccaggtcgg cggcgaggag gtgggcgtcg aggtcggcgg ggtcgccgag
     4081 cctgcgctcg acgtcggccg ggtcgacgcc ctcggtgcgc ttgatcaggg tgacgccggc
     4141 caggcccatc ttggcgtcct cgttgccggg ggcgcgggcc agcagccgct ggtaggccgc
     4201 ggcggcggcg tcgaggtcgc cgcgctcgac ggcctcctcg gccgcggcga ggtcggggtc
     4261 ggcgggcggg cccgccgggc cctcctcctc gccctccgcg ccgggcggcc gggcgcccgg
     4321 gttggcctgg tagaactgct cgacggcggc catcagctcg tcgagccagc ggcgcacctc
     4381 ctgctcgggc agcacctgct ggaagccggt gacggcctgc ccctggaaga tcgccagcac
     4441 ggtgggcacg gcctgcacgc gcagcgccgc cgcgatctgc gggctggcgt cgacgttgac
     4501 cctggccagc accgcccggc cgccgaggtc gccgacgacc ttctccagca ccgggccgag
     4561 ctgcgcgctc gccggggccc ggggtgacca gaggtcgagg acgaccggca cttgcatgga
     4621 gcggtcgacg acgtcggtcg tgaacgtctc ctcggtcacc tcgacgaccg aggccgacgc
     4681 ggcctgggga cctgcggcct cccgccgggc ctgcgcctcc agtgcctgct tgcgagcgcc
     4741 cagatcgatc gccccgtaga gcgacccggg cctagagaag tccgccatgc ccttcatctt
     4801 gccgcatcgg cgggcagtcg aagtcacccg ccgcgacccg cagggtgcgc aactggtcga
     4861 acatggcgtg gagttcgtcc tcggcgtaca tcgacaggcc gaactcggcg gccatgaggt
     4921 cgcgggtggc gtggcggacg acgtcgcggc cggagtcggt gatctcggcg agcacgcccc
     4981 tgccgtcgcg cgggttgggc agccggcgga cgtagccgga cttctccagc cggtccaccg
     5041 tgttcgtgac gctggtggga tggaccatga gccgttcgcc gatcttggac agcgggagcg
     5101 cgccggtcct gctgaaggtc agcaggacga gcgcctcgta gcgggcgaag gtcagcccgt
     5161 acggcttcag cagcgcgtcg aggtgcgaca gcaggatctg atgcgctctc atgatcgagg
     5221 tcacggccgc catggcggcg gagggcccga agtgggcgcg ccagctctcc gcggcgcggt
     5281 cgatcgggtc gaacggcagg ttgagcggct tcggctgcga cacgcagcta cgttagcgcg
     5341 ccggtcgtcc cggttcgtcg ggtgatctgg agcgacaggc tttcctcctt gaccaagaat
     5401 ccggacatca atcatcacgc tcagttatgg ttctcgtacg tatggtgacg cggaagccaa
     5461 gtccatcagc ctgtggggac cggccggact gcccgcttgc acgtcaccga ggggcacggg
     5521 gggtgctttg atggacttca acggggcaaa gggtgcgtga gcacgcgggc gtttcacggg
     5581 aggagctgaa gcagagcgcg gccgtcacgg ttgccgtgct gcttgctgtc ggcctgatcg
     5641 cggcgtggaa cgtcctgata ccgggcgtgg acgcctggga gaacatcgtg gccgcggtca
     5701 tcggctcgct ccggctgacc gggcccgtgg cggcggcctt cgccgcctgg gtggcgctcc
     5761 gcaagcgccg ggcgctgcgc gggcgctcgc tcaccacgtg gcgggcgctg aaggcgccgc
     5821 tggcgatcgt cgtggtggtg ctgggctcgt tcggggccac ggtgctggtg ctggcggtca
     5881 agacggtgct caccgaccag gcgggccggc tgagcctgcc cgggctgggc atgggcatgg
     5941 cggggctggc gctgtactcg gtgatcgggt gggtggccgg atgggtggcg cccaagccgt
     6001 tcacgccgcc gctcgccggg ctggcctgct acggggcgtt ctcgtggctg gccgacgacc
     6061 gcggctgggc cgacaagctg gcgcccggca ccggcgagcc gtacgacctg ttccaggcgc
     6121 tcagcggggc ggccttcttc gaccagacga tctggctgct cgggctgacg gcggcgctgc
     6181 tgctgggctg ggcggcgctg gtcacccggc aggcgctggt gctggcgtgc gcgctgctcg
     6241 cggtgctggc ggcgggcatg ggggtgtcgc gggtgctggc ccagacccgg ccggccgccg
     6301 ccgaggacat cgcctacgcc tgccaggact ggccgatcac cgtgtgcgtg cacccgggga
     6361 tgcgggccgg gctgaccgag ctgggggcgg tgttcacgca gatcgcgatg cgcctggacg
     6421 gcactccggc cgcgttcaag cgggtggagc agcgaccgct ggaggagaag ctgcggcctt
     6481 cgctcggcct cgcgccgatc cacgtgcccg acctgtcggc cgggttcgcg gagaaggcgg
     6541 cgtacgagta catcgagtcg ttgtccagcc cgtgcccggg cacggtcgcc gaggggtacc
     6601 gggagatcgt gatggtgtgg ctgcgcggcg agccgcccgc gggcgggccg ctggccgagc
     6661 accagtacgc cacgtcgtgg ttctcgtggc tgaacgagca ccagcggcgc gagtggctgc
     6721 gcatgttcta caacgacttc cagaactgcc ggctgtcgag cacccacttc ggcggcgccc
     6781 cggcgcggcc gcagctcgtg ccgcagtcgg tgcagccgtc gcccgactcc acgcacgtgt
     6841 accccgtgta cccggacccg ccggccgcgc cgcccgcctc gtacgtcacc cccgggtacg
     6901 tcaccccgga cgcgcccgcc ctgggttacg tcccggcccc ggcgccgggc tgggtcgccg
     6961 cggccccgcc tgcccggccc gccggtccgc gccgcgccgg cccgcgccac ggggcggacc
     7021 ggctcgccca ggcgggccgc cccgcgcagc cggcgcacgg aaggggtccc gcccgcccgg
     7081 cacaggcgtg aaccgaccag gcggaatcgg agatgtcacc ctggggctgg cactgatgat
     7141 cgctcagcgg gtagtcatgc caccatgacg acttcccgta cagcgccgcc cgaggtcgtc
     7201 accgggcgac gccgcaggtg gcgatatgca gcggggttac tggtcctggc ggtcctgctg
     7261 gtggtggccg gccgcctggc ctggacctgg ctcgacccca cgggcgagcg caccgtcgac
     7321 cgcagccagc cggtcctgct ccagtccatc aaggacctca gccggttcga ggccgcgacc
     7381 ggcaccttcc aggtcgtggt cgacctggag aaggacgcca acttcctgcc cgacgcggtc
     7441 aagggcaccc gcaccctctt cgtcggcgcg ggcggcgtgg acgcctacgt ggacttcggc
     7501 gccctcgcga cgaacgcggt gacggtctcc gaggaccgca cggaggcgac gatccgcctc
     7561 ccgcacgccc agttggagaa gcccaacctg gacaacagcc gctcgtacgt cttcgcgcag
     7621 cagcgcggcc tgttcgaccg cgtctccgac ttcctgtcgg gctcgcccgg cgaccagcgc
     7681 gagctgtacc tgctggccga gaagaagatc accgaggcgg ccgtggcgag cgacctgcgg
     7741 gcccgcgccg acgccaacac caaggcgatg atgacgggcc tgctcaagtc gctcggcttc
     7801 accaaggtca cggtcaagtt caccgacgag ccctgaccgt aaggcgttcc tagggccccg
     7861 cacacccgtc ttaggacccc tgtgcgcacg gcctaggtac cccgtcccga gtcctagggc
     7921 gagagatagg acatacgccc gatgtgccgg gaagggcctt aggagcaatc ttgagagtgc
     7981 agacagcagg caccaccgaa tcgccttcag gagcactcca gatgaacgcc gaactcgaat
     8041 acagcatcat gcagcaccac gcctccgagc tccgccgggc cgccgccgag cagcggcggg
     8101 tacgcgaggc gctgcggagc tcgcgggccg accgccggca ccgctcggtc ttcgcccgct
     8161 tcctcgcctc atgaccgccc acaagcagcc cggccgcacc ctccctcgcg gccgggctga
     8221 acaacccccg taggggggat ccggatccgg gtcctggtcc cggcgccggc aggcacacgc
     8281 gaagccccgg tcctttcctg gttgggccgg ggcatcgcgc tgcccggggg cgcgaggcga
     8341 tcagagcgtg atcacgagct tgccgtgcac gtggcccttc tccagctcgc ggatggcctc
     8401 gggcacctgt tccagcgggt acgtcccgct caccaccgcc ttgatccgcc cgtcgccggc
     8461 cagctcggcc agcgtccgca ggtccgcctc gcgggggaag gcgaagacca cccggggccg
     8521 ctgccgggtg aacggcccga gcagcaccgt gcgcaactgc cggtccaacc cggccagcca
     8581 ccggccgccg ccctccccgc ccacgatgac gaaggtcccg cgcggcgtga gcgcccggcg
     8641 caggtgggac agggggcgca ggcccgccgt gtccaggatg aggtcgtagc ggggccggcg
     8701 gccgtcggcg aagtcctcgc gggtgtagtc gacgacgtcc tccgcgccga gcgagcggac
     8761 cagctcggcc ttcgagccgc tgcacacgcc ggtgacgtgc gcgccgaagt gcgcggcgag
     8821 ctgcaccgcg aacgtcccca cgccgccgcc cgcgccgatg accagcacgc gctgcccggg
     8881 ccgcacccgg ccggcctcgc gcagcgcccg cagcgcggtc atgcccgccg tagggatggc
     8941 cgccgcctgc tcgtacgaca ggttcgcggg catcgggacg agccggcccg ccggggcgca
     9001 ggcgtactcg gcgtaggccg cgccgcaggt gccgaagacg cggtcgcccg gcttgtacgc
     9061 ggtgacgccc gccccgacgg cccgcacctc ccccgccacg tcggtgccga cgaaggggct
     9121 cttcgggccg cgcaggccgg tgccgagccg catgacgtag ggcaggccgg tcagcacgtg
     9181 ccacacgccc tggtccacgc cggccgcgcg gacccgtaac accacctcgt cgtcgccggg
     9241 cacgggctcg gcgacctcgc cgaggccgag gacgtccgcc gagccgtacg cctgccgggt
     9301 gatcgctctc atcggttctc tccgtccggg tactggaaca cgtcgtcgag cgggacgccg
     9361 aaggcccgcg cgatctggaa ggccatctcc agggacggcg agtaccggcc ctgctcgatg
     9421 gcgatgatcg tctgccgcgt gacgccgacc cggtcggcca gctcggcctg ggtcatctcg
     9481 ccgtgcgcga agcgcagcgc ccggatcgag ttggtgacct tcgtgggctt caccatcccg
     9541 gcatcccccg ccggtaggcg acgatcttga gcgtggaccc gaggacggcc gacaggacga
     9601 accccaggta gagcacgttg gcgatccaga agtgcgggat ctcggccatc gccatgacga
     9661 gcgcggccag cgccccggcg acgaggaacc actgcccggc gtactcgccg tagcggtgga
     9721 tctcgcggtc gcgctggtcc ttgctgccga tgtcggcggg cgagagcagg ctgaccgcga
     9781 tgaacgccac gatcgaggcc gcgcacgcgc cgccgacgct ccacagcagc ggcacgacgt
     9841 agggcacctc ggcgagcggg acggagcccg cccggccgag gatcgtcgcg aggtaggcgc
     9901 cgtacgcgag caccgagacc accaccatga tccaggcgcg tttctcttcg ggaggcatgg
     9961 ctcgaatgta aaacagcgcg gacatcatgt ctacaatttt ttacatcgcg caggtcgtgg
    10021 agggtgtgcc gaagggcccg gacgacgagc cggcggtgct cggctcgctc ggcgccgggg
    10081 ccgcgctgtc gtgcacggcc cggcgggggc ccggcggcag cggcacggag gcgtggtcga
    10141 ggtccacgta acggctgttg ccgaggtgcc aggccaggtt gccgcccatc aggtcgcgca
    10201 ggccccgcac gtacgccggg ccgtcgcgct cgccgagccc ggccgccggc tcctcggccg
    10261 ccagcgtctc gaagacgcga agacaggtcg cgagctggtc gccgaggacg tccacggcct
    10321 gctgcagccc gcagcccagg aagtcctgga cggccaccac cccgttgttg gagtgccgct
    10381 cgacctcccg ttccaggctg taggagacga tgtcgttgac caggcagacg tggtcggcgc
    10441 aggcgttcac cagctcgcgc gcggcccggc cggcgagcag gcgctccggc ggctccagcc
    10501 cgagcgccag cgccatcagc cgggccccca gcccgctcac gcccttggcc gcccgcgaac
    10561 gcacgaggta gtccaccgga tcgggcaccc ggcggcggac gctgtgcgcc atctcccaca
    10621 ggttgcccgc cgcgaaacgc agcacgtcct cccgcaacgc cggccgccgg ccgggcggca
    10681 gcagcgggac ggtgcgcgcc cacaggtccg ccagcccgcg ctccacgtga ccgcccgtcc
    10741 ggggcccgcc cgccgtgccg cccgccgtgc cgcccgccgt gccgcccgcc gtgccgcccg
    10801 ccgtgccgcc gggcaggggc atgaagcggg ccaggccctc gacgaaacgg ccggcgccgg
    10861 cgaggtcgtc gcgggccttg tagccggcga tgaagaagtc gtcgacggcg agcgcccagg
    10921 tgaaccagag cgccaccagc tccaggcggt ccggcgcggc gtcgggggcg gccatcgcgc
    10981 accagccggc gaagcgcatg gcctcgaacc ggcccggcgt ccacaccgcg ccggggccgc
    11041 cgaccatgcc catctcccgc gcccactcac cggccgcgcg ctgggcgccg gcccagtgcg
    11101 ggttcacccg gacggtccag ggcagcgcga gatccggcaa ccggaacgga taccccggcg
    11161 aatgctcccc caccgaccgc ccgcccactg gccgctcgcc cgatggccgc tcgccagatg
    11221 gctgcccgtc agatggctgc ttgtcagggg gccgcccgtc aggtcgccgc ccgtcgagtg
    11281 gccgctggtc cggcggcccc tgctcaagcg gccgctgctc gaattgccgc cgctggtcca
    11341 gtggcccgcc atccgccgac cgctcgcccg atggccgctc gccatccgac cggccacccg
    11401 ccgaccgctc gcccgatggc cgctcgccat ccgaccggcc acccgccgac cgctcgcccg
    11461 atgaggggtc gcccggcgcg ggccgcccga cgcggggccg cccgacgcgg ggccgcccga
    11521 cgcggggccg cccgacgcgg ggccgcccga cgcggggccg cccgacgcgg ggccgcccga
    11581 cgcggggccg cccgacgcgg gatcgcccga cgcggggccg cccgttaccc gggcgcgcgt
    11641 cggccgccac cggtgggcgg aggcgtcagg gggcggggtg gggtgccagg tggcgtggcc
    11701 ggtctgccag tcgcggaggg cggcgacgta gcggcagagc cggtcccgtt ccccggtccc
    11761 gagccgggcg gcctcggcga gcagcgggat cccggcgagg gcggcgtgct cgaagcgccg
    11821 cagccgggac agccgcagcc ggtccacccg ctcggccgcc gtccgcgcgt cgcagcgcag
    11881 gaaccgctcg aacaccgcca ccgcgttcca gccgggcccc caggcgggct cgccggccgc
    11941 gtggccgcgc aggtcgccga gcagatgcac gccgtcggcg aaggcgtcct ggacggcccg
    12001 gaccgcccgc gcctccacca ccgcctccgg cagctccgcc ccgccgacgc gttcgacgag
    12061 tacggccgcc caggccgcgc ccccgcagga gcgccacgcg gcgacgtact ccagggggtt
    12121 gggggcccgc ccggcggcga ggccgtccag caggcgcagc cgcccgcgca cgagactccg
    12181 ggtgctgtcg gcgaacctgc ggcgccacgc gccggacgtc ggataccgcg cctcgtccag
    12241 gcgcgccgta cgggcccaca gctcggccag ggcgcgctcg cccggcccgg acggggaggg
    12301 cgggcgctcg tccgcctcct cggggacgag gcgggccagc cggtcgagga accgcccggc
    12361 ctgccgccgc tcaccccggt acgtgccgaa gaagtggtcg tcgagccagg ccgcccacac
    12421 gtaccagtcg gcggccagtt ccagctcctc ggcgttcgcg ccgggatggc agtggccggc
    12481 cttggacgaa agggccaggg actcgaacct ggtctcgtcc caggtctcca gcaggccctg
    12541 ctcctgggcc caggcccggg agcgctggtg ggcgggagcg ggcggatcgg gggtggggtt
    12601 ggcggagggc tgcgacggca tcgttgcctg cccgtcgttc ggggagggga ggcgggtgtg
    12661 aaagttgtga ctccattatg cacacggaga gtaatgtgaa tgcaacgctt cgcgcacatt
    12721 gtgcggagcg ggatcggcgg ctcatgatgc cggtatgcgc aagcggaggc tcgtgtggac
    12781 cggggccgcg gtcacggtgg cggccctggc ggggctcggc gtctacttcg cccgggtggg
    12841 gctggacgcc gccgacaagc tgtccagcgt gatcggcgtg ttcgccgcgc tgatcgggtt
    12901 ggccctggcc ggatacggcg cgctccccgc ccgcgccgcc cgcgccgccg gggaggcggc
    12961 ggaggacgag gctccttccg tgacggcctc gggcacccgt tcggtcgccg tcggcggcga
    13021 caacagcggc gtcatctcca ccggcgacgc cgcccgcgtc cacctcgcga gcgacgaccc
    13081 gccggaggac gcggggccgt gaccaggacg tgagtgccgt gatcaggacg cgggggccgt
    13141 gatcagcgct tcggcacgct gatgagcagc gcgtcgccct ggccgccgcc gccgcacagc
    13201 ccggccgcgc cgagcccgcc gcccctgcgc ctgagctcgt gggcgagggt cagcacgatg
    13261 cgcgccccgg acgccccgat ggggtggccg agcgcgatgc cgccgccgtt gacgttgacc
    13321 ttgtccagcg gcacgccgag ctccttggcc gactggagca ccacgctggc gaacgcctcg
    13381 ttgatctcga ccaggtcgag gtcggcggcg gtgacgccct gcttggccat ggcctgcttg
    13441 atggcgttgg ccggctgcga ctgcagcgag gcgtcgggcc cggccacgtt gccgtgccgg
    13501 ccgatctcgg ccagccacgg gaggcccagc tcctcggcct tggccctgga catgacgacc
    13561 accgcgcagg ccccgtcgga gatctgcgag gccgagccgg cggtgatcgt gccgtcggcg
    13621 gcgaaggcgg ggcggagctt ggccagcgtc tccacggtgg tgtcgccgcg cacgccctcg
    13681 tcctccttga cgagcaccgg ctcgccgcgg cgctgcggaa tcggcaccgg cacgatctcg
    13741 tcgtcgaaga cgccgttctt gacggcggcg gcggcgagct ggtgggagcg ggccgacaga
    13801 gcgtcctgct cctcgcggcc gatgccgagg cgggcgttgt agcgctcggt ggactcaccc
    13861 atcgcgcact ggtcgaaggc gcagaacagg ccgtcgtggg ccatcgagtc gaccacgtcg
    13921 gagccgccgt acttgacgcc cttgcgcagg ccgggcagca ggtggggggc gttggtcatg
    13981 gactccatgc cgccggccac cacgatgtcg aactcgccgg ccctgatgag ctggtcggcc
    14041 agcgcgatcg cgtcgaggcc ggacaggcag accttgttga tcgtgatgga cggcaccgtc
    14101 atcgggatgc cggccttgac ggcggcctgg cgggagggga tctgcccggc gccggcctgg
    14161 aggacctggc ccatgatcac gtactcgacc gactcggggg cgaccccggc gcgctccagc
    14221 gcggccttga tcgcgatgcc gcccagctcg acggccggca gcccggacag tgcgccgagc
    14281 agcttgccga tgggggtgcg agctccggcg acgatgacgg atccagagac tgaaccggac
    14341 atgacaacgg cctcctgtgc tcgcgcgtcg ggtctttgac acgataccca cgggtaggac
    14401 gtcgctcgcc atggaggtag gccacacatg ttcatgcgga tcgaccacat agggatcgcc
    14461 tgccgggatc tggaggagaa gatccgcctg ttctcggaga cgttcgagct cacggtggtg
    14521 gcccgcgagg tcaacgagga gcagggggtg aaggaggcca tgctgcacat cgcggacggc
    14581 gagggcggcg gctcctacat ccagcttctg gagcctttgt ccgaggactc acccgtgggg
    14641 aagttcctcg cccggcgcgg cgagggcgtc caccatgttg cgttcggtgt acgcgatgtc
    14701 accgaaacca tggctaagat cggcgcaaag ggtgtgaggc tgctggacga gcgtccgagg
    14761 cacggttcca tggattcccg gatcgccttc ctgcatccca aggatgtggg gggaatgctc
    14821 acggagctgg ttcaagccgc cgatcccgac aaatcgtaaa aaacgttcat atgtaactag
    14881 tcacgcagaa aattggacgg ggcttcgcag gcggcaccgg cggagtacgc tggacctccc
    14941 gaccggacag ggagcctgcc gtgaggcaca ggctcccggc tcggatgccc cgaacccccc
    15001 gtccggcacc tgtagccgtc tcgacaaccc aggatcgagc ctccatgcag tccgacatcg
    15061 acgcccagct caacaacttc ttcgaggacg cacccgcacg cgagttcgat gtggtgcttc
    15121 gtggttacga ccggcatcag gtccacgatc acctcaagca gctcgaccag gagctacgcc
    15181 aggcgcgcga gcagatcacc ggcctgcagc gcgatctgtc cgactcccag cgccagctgc
    15241 aggagcagga gcgcccgacc tactccggtc tcggcgcccg catcgagcag ttgctgcgcc
    15301 tcgccgagga gcaggccacc gagctcgtcc aggccgccag gtccgaggcc aacgagatca
    15361 aggccgccgc caaggtcgag gccgccgacc tgcgcgccgc cgccgaggcc gaggccgccg
    15421 agaagcgcgc ccaggccacc cgcgagagcg acgagatgcg cacggccgcc gagcgcgacg
    15481 ccgaggagat ccggggcacc gcccgccgcg aggccgacga gctgaccaac accaccgagc
    15541 gcgaggtcgc caagctgcgc gccacggccg accacgaggt ggccgagaag cgcgccgacg
    15601 ccgagcgcga gatcgccaag ctccgcacca ccaccgagcg cgaggtggcc cagctgcgtg
    15661 cctcgaccaa gcgtgagcgc gacgaggtgc tgaccaccgc caagcggcag gccgacgaga
    15721 tgcgcgccca ggcgcagcgg gtgctggagg agtcggaggc caagcgggcg caggacgagg
    15781 cggagttcga gatccagctc gcctcgcgcc gcgaggaggc cgagcgccag gaggccgagc
    15841 ggcacgccac cgcccaggcc gccacgcaga agctggtcgc cgaggccgag cagcgcgccg
    15901 ccaccgccga gtcgcgggcc acgaaggcga cccagcaggc cgagcagacc cgccgcgagg
    15961 ccgacctgca cgccaagcag ctcgtcgcca acgcccgcaa gagctccgag tcgatcgtgg
    16021 ccgaggcgaa gtcgagcgcc gagaccatcg tcaccgaggc gaagaacgag gccgagcgca
    16081 cccgcaccgc gatgcagcgc caggtcgacg agctgacccg ccagcgcgac agcatcacca
    16141 gccacctcgc gcagctccgc cagctcctcg gcggcgccgc gctgccgggc atggaccccg
    16201 agcccgcggt caccgcggcc ccgccgaagc ccgcgatccc ggcgcccgcg cccgtggccg
    16261 aggcgccgcc cacgacgccc gcgcccaagg tcgaggccaa gagcgacgac gacgcggagt
    16321 ggtggcagga gtaagcggca cagaagtgac ggcaggggtg tccggcacgg gggccgattg
    16381 acggctgggc tgattgacgg ctggagagag cctggcgatc gaggagatcg ctaggctctc
    16441 tctgtgtttc cggcccgatc tggggggacc ggcccgatct gggaggagtt gctcgccgtt
    16501 gtccgcgaat gccgagaccg atgtcgagga tgccgccgga gccgcagccg aagccgaggc
    16561 caaggccgag gccggagccg aggccaccgg agccgaagct gaggccaccg gagccgacgc
    16621 caccgagcgg cagccgtacg ggctgcccgg caagccgctc gcccgcggcc cgttcctgtt
    16681 cgggctggtc ggcggcctgg gggtgctgac ggcgatcgcg atcgcgcaga tggtcgtcaa
    16741 ctcgctgagc acgatcatcc tcgtcgtggt ggcgatgttc ctggccgtcg ggctcaaccc
    16801 ggccgtggag gcgttgcagc ggcgcggcct ggccaggcgc gcggcgatca cgatcgtgtt
    16861 cgccggggtg atcgtgacgt tcgcgctgtt cgggctggcg gtcgtgccgc cggtgggcaa
    16921 ggagctggcc gacttcgtcg ccgccgtgcc gggctacctc gacgagctga gcagccatcc
    16981 gacgctgaag cagctcgacg ccgactacca gatcctgccg cagctcgcgc agttcgtgac
    17041 gaccacgctc ggcccctcgc tcgccaccgg catcatgggg gcgagcctgg tggtgctgga
    17101 cggcgtgttc accacggtga cgctgctggt gctcatgctg tacttcctcg gctcgctgca
    17161 cacgatcaag gcgtacctgc tcaagctggt gccggcctcg cgccgggcgc gcacgggcgc
    17221 gatcagcgag gagatcctgg ccgggatcgg cggctacgtc gccggcaacg tgctcatctc
    17281 ggtcatcgcg ggcgtgctga cctggatctt cctgtcggtc gcgggcgtca agtacgcgct
    17341 cgcgctcgcc ctggtcgtcg cgctgacgga cctgatcccg ctggtgggcg ccacgatcgg
    17401 ggcggtggtg gtgacggccg tggcgctgct gcagtcggtg ccggccggca tcgcctgcgc
    17461 ggtcttcttc ctcgtctacc agcaggtgga gaactacctc atctatccgc gggtgatgaa
    17521 gcgctcggtg gacgtgacgc cggccgtcac cgtgatcgcc gcgctgttcg gcggcgcgtt
    17581 gctgggcatc gtgggcgcgc tgctggcgat cccggtggcc gcggccatcg cgctgatcat
    17641 ccgcgaggtc gtcatcccgc ggcaggcgcg ggcctgagcg tcagaagggg gcgacggcgc
    17701 cgagctcgtc aggagcgggc gacgccgagc tcggcgtgca ggaactccga cacggccgcg
    17761 ttgaacgcct cgggctgctc gaccgcgctg aggtgacccg ccttggggat gacctccagc
    17821 cggccgccgg gggccgcctc cgccatggcc ttggcctcgg cgggcggcgt cagctcgtcc
    17881 tcctcgccca cgacgaccag cagggggacc ttcagcgcgg cgagcgtgtc ggaggagtcg
    17941 gggcgcgcgg ccatggcgcg ctgcgcccag gcgaccgcgc ccggcggcgc ggactgcacg
    18001 agccccttga cccggccgaa caccatggcg cgccgctcct tggtggtggg cccgatgagc
    18061 gccggcagca cctcgctgac cagcacgtcg ctgccctcgg acaacacggc ctgcgcgatg
    18121 cgctcccggt tggcgcgcgc cggggccggg tcggggacgg ccttggtgtc ggcgaggacc
    18181 gcgccgagca gccggtcggg gtgcctgcgg cagaacgcca gcgtgacgta gccgcccatg
    18241 gacagcccgc ccaccacggc ccggtcgacg ccctcgtcgt cgagcagcct ggcgacgtcg
    18301 tcggccatga ggtcgagcga cggctcgtcg tcgcccagcc gggagccgcc gaagccgcgc
    18361 aggtcgggcg tgatgacccg gcagaccttc ctcagccctt cccgctgggc cagccacatg
    18421 gccgacgaca gcgggaacgc gtgaagcagc acaaccggga gcccggtccc ggacgatctc
    18481 gtgtagagct gcacggcccc cacggtaacg cggttcacgc tcttgagcac acgatgtcgc
    18541 atgccgatat gccgcaaagc gtacgaccgc ttcggtaacg cctcagatcg cggtggcgcc
    18601 gccgtccacg aagagcacct gcccggtcat gtacgccgac gcctcgctcg ccaggaagat
    18661 cgccggctgg gccatctcct cgacggtgcc ccagcgccgc atgggcacgg cggcgaccgt
    18721 ggccgcgccg ccgctctcgt cgtcccagag gttgcggttg agctcggtgg ccgtccagcc
    18781 ggggcacagg gcgttgaccc ggacgccggc cgccgcccac tccacggcca gcgtcttggt
    18841 gagcgcgacc accccggcct tggcggcggc gtacggggcc aggaagggcg cgccgagggc
    18901 cgccaccgag gccacgttga tcaccgaccc gctcccccgc tccagcaggt gcggcgcgac
    18961 cgcgtggcag acggccatgg ccgagtcgag gttgagccgc atgatcttgt cccagccgga
    19021 cagccgcagg tccttgaact cgaccatgaa gttggagccg cccgcgttgt tgacgacgat
    19081 gtcgaggtgg cctagcccgt cgacggcggc ggccacggcc ccggcggcgg cctcgcggtc
    19141 ggtgaggtcg gcgggcagca ccacggcccg gcggcccagg gcctcgatct ccttggcgac
    19201 ctcggcgagc gtctccgccg accgggacac cagcgccacg tccgcgccgg ccgcggcgta
    19261 ggcgagcgcg accgcccgtc cgatgccctt cgacgccccc gtgaccaggg cctgcttgcc
    19321 gctcagatcg aacgcgccca acgccgcctc ctccatgccg tgccccgaca gaccgaaccg
    19381 aacaagattc tacggaggcc ggccccgggt acgccaccgg cgcgggacct cgtgagtccc
    19441 gcgccgggtg cgccctggtg aggctctatc gtccggtcat catcgtccgg tcatccgccg
    19501 aggccgaagc cgtcgatgat gtcggcgatg ctgtccatca gcttgtcggt gcggttgaag
    19561 agctgcgtct gcaggcccct cttgttcggt tcgagctcga tcttctcggg cttgaagatc
    19621 tgcttctcgc cctggcccga cccgccgccg ttcggcaggt tggacggcgg ccggccctcg
    19681 gggtacagcc ggccgttgcc gtacacgctg tacgactgcg tcggctgcgt ggtcccgtcg
    19741 ttccggtaga cctggctcgg tctcggctgc gccggctgcc tgctcgcccg cggcggcgag
    19801 tgccgctgcg ccgcgcgatg gctcgtcgga cgccgcgccg gggtggaccg ggcccgctgg
    19861 atgccccgcg ggacgcggcc gcggtagtgg ttgcgcttgc gggccgccag agccagccgc
    19921 cgcttggccg ccgcctccct ggccgccttg cgcgccgccc ggcgggccgc gagcgccgcc
    19981 cgccgcttgg ccgcggcctc gcgcgcccgc tccgccttct cccgcgcctt cttcctggcc
    20041 gcggcgagcc gcttgcgctt ggcctcggcc gcggcccgct tcttggccgc ctcacgggcc
    20101 cgcttcttgg cctcctcggc ggcccgcttc ctggcctcgg ccagcgcgcg cttgcgcgcc
    20161 gcctccctgg cccgcctgat ggccgcccgc cgcagggccg ccgcggccgc ccgctgcgcc
    20221 gcccgcttgg cgaggtagcg ggcgccgatc cgcacgccca ccgcgaccac gatccacacc
    20281 cactgcccgt cggggtcgct catcgtgacg gggctgttgt tggcgtaggc gtaggcgttg
    20341 agctgctgcg ggtccacgtc gtcgatgacc gggtccaccg acaggaagcg gccgagcttg
    20401 gggtcgtact cgcgggcgcc caggtgcacc agcccggtcg tggcgtcctt ggtgccgccg
    20461 acgaacccgc gctggcccgg ccaccagggt ggcggcgagc cccggtcctc gccgaacggc
    20521 gtcgtccgcc gcaccgccag ctcgcccgtc gcggcgttca ccgcggcctg cgccgtgccc
    20581 tggtggtcgt tgaccaggaa gaacacctgg ttgtccgggg tgcggacggc gatcggctcg
    20641 tcgttgatcg tgtagtagcg ggtctgctcg accgtgtcct tgccgtagtc gaagcgcagc
    20701 tccatgtcgt cgatgtagag ggtggcgtcg gtcggcgtct tgcggatcag ccggtcgccc
    20761 tcggcgtcgt agatgaacga cgtcgtcttg cccgcctccg tcaccgactc caggttgccc
    20821 tcggcgtccc agaccaggct ctggtcggcg gtgccgatct tgcgcctggt ggtgttgccc
    20881 gcggcgtcgt actcgaacag gtcggcgccg acgctctgca gcgcgtgcgg ctgcttgccg
    20941 ccggcctgcg ggtaggtgta cgtgcgcgag gtctcgcccg cgccgcccca ggcgtgcctg
    21001 gtctccttga tccggttgcc ggtggagtcg tagccgtagc tgaccgcgta cggggccacg
    21061 ccgccgatcg tgccggactg cggggagccg gacgcgcagt cgtccgtggc cgtccacgcc
    21121 gaggtcagcc ggcgcaggtg gtcgtaggtg aagcactgcg tgtcctgacc gccggcctcg
    21181 gcgatcttgg tgatgttgcc gaccgcgtcg tagctgtagc ccaggtcgag gtcggtcttc
    21241 gcggcgccct cacggtcgag ccggaagctg gtcagccgcc gggtggactc gtcgtggttg
    21301 taggtgagcc acgccttctt ggtgccggag ccgcccagct cgtactgcag ggtctcgccc
    21361 agcttggagt agcgggtggc gttgacgtac gtcgtcaggc cggtgacctt gaccggctgc
    21421 gcgagcccgt cgtagccgta gacgacctgc tcctcgggca gcccgccgac gccggggaag
    21481 ctgaccgact gcacctggtc gtcggccgtg tagcgggtgt tgagcacata cgagccggcc
    21541 agcttgccct cgcgctcggg gatggtgacc gtctcgcgca gcgggcggta gtcgacgtcg
    21601 atggcgttga tctcggcctt gtacgcctgc ccgcccacgt accggatgct ggcgttcatg
    21661 tggcccttgg ccagcgcgtc gtacttccac tcggccagca gcgggccggt ggccgagccc
    21721 tcgcgcatct ccttcttgcg gcccagctcg tcgtagacgt agtacaacgt cttgccgcgc
    21781 gagtcggtcg tggagaccag ctcgtcggcg tcgttgtacg tcatggtcgt gacgcccttg
    21841 tcggggtcct cggtcttgat ctcccggccg cgcatgtcgt agtggtggcg ccacacgttg
    21901 cccgcggagt cggtcaccgt ggacaggcgg ccggcgtagt cgtaggtgta cttggtggac
    21961 tcgtactcgc cggtcggggt ctggcccttg tactggcgca gctcgatcag ccggtcctcg
    22021 gagtcgccga tgcgggtggt cgcggtgcct cccggcggcg gcgtgatgtg gatccggtcg
    22081 ccctcgttga cgaccgacac ccggtacttc tccacgccct tcgccttgag gatctgggcg
    22141 ctggcctcgc cggtgccgtc gaacgtcgtc accacctggt tcggcaccgc cgcgtcggtg
    22201 acgccgagca ggtcggtgga gggggtgccg gtggcgaagt agccggtgtt cgacttgtac
    22261 tgctcgccct gcgagttgta gaaggtgtcg gtgaccgtgc ggccgtcgcg cagggcgggg
    22321 tcctgcgtct ggtcgtccct gggcgcgggc tcctgggtct ggcgctcgcg catcaggccg
    22381 tcgtacagct cgtagctggt ggtgtagccg ccgtcgtcgc gcagcgtctt ggtgacgacg
    22441 tagctcggcc cgtccgagcg catcacgtag gagtactcgg tgttgggcgt ctgctgggcc
    22501 gccttgctgc ggtcggcctg ccacaccttg accaggcggc cgagcgcgtc gtgctccatc
    22561 tccacgcgcc ggttgttcgc gtccacctcg gcgacgggct cgccccaggc cggctcgacg
    22621 t
//
