LOCUS       NZ_JAKRKC020000002     21071 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Actinomadura luzonensis strain ATCC 31491 Contig00006, whole genome
            shotgun sequence.
ACCESSION   NZ_JAKRKC020000002
VERSION     NZ_JAKRKC020000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura luzonensis
  ORGANISM  Actinomadura luzonensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Genome draft of Actinomadura sp. ATCC 31491
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Genome draft of Actinomadura sp. ATCC 31491
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
REFERENCE   4  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
REFERENCE   5  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
REFERENCE   6  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. v1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 89.6x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022664455.2-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 18:46:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,232
            CDSs (total)                      :: 10,155
            Genes (coding)                    :: 10,004
            CDSs (with protein)               :: 10,004
            Genes (RNA)                       :: 77
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 151
            CDSs (without protein)            :: 151
            Pseudo Genes (ambiguous residues) :: 0 of 151
            Pseudo Genes (frameshifted)       :: 36 of 151
            Pseudo Genes (incomplete)         :: 126 of 151
            Pseudo Genes (internal stop)      :: 3 of 151
            Pseudo Genes (multiple problems)  :: 14 of 151
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:31:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2982238
            Orig. end                         :: 3003309
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAKRKC020000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21071
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="9"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21071
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21071
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11071](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11071)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            511..1821
                     /gene="allB"
                     /locus_tag="MF672_RS44225"
                     /old_locus_tag="MF672_044225"
     CDS             511..1821
                     /EC_number="3.5.2.5"
                     /GO_function="GO:0004038 - allantoinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0050897 - cobalt ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0000256 - allantoin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="allB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541666.1"
                     /locus_tag="MF672_RS44225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044225"
                     /product="allantoinase AllB"
                     /protein_id="WP_242381480.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2.3e-23, bitscore:
                     80.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQLDLVVRSRRTVTPEGERPAAVAVRGERVEALHAYDAPLDAAE
                     DVDLRDLALLPGLVDTHVHVNEPGRTHWEGFASATRAAAAGGVTTIVDMPLNSLPPTVS
                     VAALEAKLAAARGQCHVDVGFWGGAVPGNVKDLAPLRERGVLGFKCFMSPSGVEEFPPL
                     EGGELRRALEEVAGFGGLMVVHAEDPALLAEPAGPGYPEFLASRPGEAERSAVRRLVEL
                     SRETGARVHVLHVSSAACLDVLAAARADGVPVTAETCPHYLTLAAEQVPEGATAFKCCP
                     PIRSAANRDLLWEGLAGGVLSCVVSDHSPSTADLKVPDFAAAWGGIASLQLGLAAVWTE
                     AARRGHRLADVARWMAAAPAALAGLPGKGAIAPGNDADLVAFDPAADNPVDAARLHHKN
                     PVTPYHGRVLKGAVLTTWLRGRPVDGVPHGRFLLGEQ"
     gene            1822..2787
                     /gene="alc"
                     /locus_tag="MF672_RS44230"
                     /old_locus_tag="MF672_044230"
     CDS             1822..2787
                     /EC_number="3.5.3.4"
                     /GO_function="GO:0004037 - allantoicase activity [Evidence
                     IEA]"
                     /GO_process="GO:0000256 - allantoin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="alc"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541667.1"
                     /locus_tag="MF672_RS44230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044230"
                     /product="allantoicase"
                     /protein_id="WP_242381481.1"
                     /transl_table=11
                     /translation="MTRFTELPDLALRTHGGAVVAASDESFAEKESLIRPGRPGFRAGT
                     FGPKGQVYDGWETRRRRAPGHDWALVRLGVPGVIRGVVVDTAWFTGNYPPHARVEAACV
                     EGHPSPEELLAADWAEIVPRSELKGDAEHLFPVAGGERRTHVRLSIFPDGGVARLRVHG
                     EPRPDLTPYDGLGLDLAALASGGLVTACSDGFYSAPHNVIAPGLARHQAEGWETARRRD
                     GGNDWLVIRLAGRGVLRLAEIDTTNLIFNAPAAVTLTGFDGEPGAAAPVELLPRTRLQP
                     DTPHRFRLGAAAGVPVTHVRVDIHPDGGLARVRLHGHLTP"
     gene            complement(2818..4890)
                     /gene="pknB"
                     /locus_tag="MF672_RS44235"
                     /old_locus_tag="MF672_044235"
     CDS             complement(2818..4890)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889483.1"
                     /locus_tag="MF672_RS44235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044235"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_242381482.1"
                     /sec_met_domain="Pkinase (E-value: 6.7e-52, bitscore:
                     173.9, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 3e-06, bitscore: 24.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTTTADPLVGRLLDGRYRIESRIARGGMATVYLALDVRLDRTVA
                     LKVMHRSLAEDPAFVRRFIGEAKSVASLSHPNVVHVFDQGTDNDVVYLSMEYVPGRTLR
                     DVLRERGRLPAREALEILIPVLAALGAAHQAGMVHRDVKPENVLMTDDGRVKVVDFGLA
                     KAIEATNQTRTGVMIGTIGYMAPEQVLTGAADVRSDVYAAGIMLFELVTGQQPYDGETP
                     MSVAYRHVHDTVPAPSSLTPDVPPLIDTLVAQATAREPQDRPKDATALLVAAVDAHRML
                     PRTTIPPLSHARPYGPMRGSGAMSAPVTGSMAAPAAASLPGPAPVPMAGSMAGSMAGSA
                     PGLRPQPPSQPNDRTAVHAAPSVPQVAPAHTLVQPRAEVPGRRRRGFRPNWFLVALAAF
                     MVVAIGLTGWFFAQPDYVHVPDLVGKSMALAQQDAAKGGFKIRTGQGQYDEKTAEGLVL
                     STDPLAGTEVEQGATITLTPSLGPKRVVVPNVTGMNGNDARAAIAKEGLTVGSVKRLPN
                     TEVERDKVIRTSPQVGEKVKEGARISIFVSAGLVMPDVGGMPKDEAAGYLGQQGFSVQV
                     QEIDDDAEPCTVIAQVPKAKSEVDRGAQVTVTVARCQTDFWDWFGRGDNQARDDQQFAL
                     VPQVIGKNVEDARRELAALGFRVEVHRLGNRGVVQFQRPLPSSERPPGSTVHLWQ"
     misc_feature    complement(4859..4874)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.63"
                     /tool="antismash"
     gene            complement(5069..5824)
                     /locus_tag="MF672_RS44240"
                     /old_locus_tag="MF672_044240"
     CDS             complement(5069..5824)
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541669.1"
                     /locus_tag="MF672_RS44240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044240"
                     /product="thiazole synthase"
                     /protein_id="WP_302893381.1"
                     /transl_table=11
                     /translation="MDELIIAGEKFASRLIMGTGGAPSLEVLDQALAASGTELTTVAMR
                     RLDPAARGSVLDVLRERGIKVLPNTAGCFTAGEAVLTARLAREALGTNWVKLEVIADER
                     TLLPDPIETFDAAERLVADGFVVLPYIGDDPALARRLEQAGCAAVMPLGAPIGSGLGIR
                     NPHNIELIVEAASVPVILDAGIGTASDAALAMELGCDAVLLATAVTRAQRPDLMAAAMK
                     AAVSAGRLARQAGRIPRRRYAEASSPMTP"
     gene            complement(5817..6017)
                     /gene="thiS"
                     /locus_tag="MF672_RS44245"
                     /old_locus_tag="MF672_044245"
     CDS             complement(5817..6017)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541670.1"
                     /locus_tag="MF672_RS44245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044245"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_242381483.1"
                     /transl_table=11
                     /translation="MIVQINGAAHELADGTTVAQAVRALTTATTGVAVAVNDEVVTRGA
                     WETTALRDSDRVEVLTAVQGG"
     gene            complement(6014..7279)
                     /gene="thiO"
                     /locus_tag="MF672_RS44250"
                     /old_locus_tag="MF672_044250"
     CDS             complement(6014..7279)
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591122.1"
                     /locus_tag="MF672_RS44250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044250"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_242381484.1"
                     /sec_met_domain="DAO (E-value: 2.6e-70, bitscore: 235.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDANAGGAAAGLSTTTAGLSGAGGGLSGLTDVVVGGGVVGLSVAW
                     RLARAGRRVAVVDPRPARGASHAAAGMLAPISEVTYTEAPLLRLGMASLRRWPAFAAEL
                     AADAGLPATGPGVDLRAEGTLDVAFGADDLAALDELAAFMDKLGLPVERLTGRECRRLE
                     PMLAPSVRGGLLAAGDAWVDPRRVTAALLAALERLRVPLVRARATGLLREDDTGAEPPG
                     AGRVVGVRLEEGAGPSEVRAGRVVLAAGAWSGGLAGVPVRPVKGQILRLRSPRPLLTRC
                     VRGSVHGSSVYLVPRGDGELVVGATQEELGFDTRVTAGGLYELLRDARELVPGVTELEL
                     ADVVAGLRPGTPDNLPVIGPGGAPGLVLATGHHRGGVLLAPLTAALVAGESGGEEAAEL
                     DALGALCSPARFHESGGVQEIA"
     misc_feature    complement(7266..7277)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.75"
                     /tool="antismash"
     regulatory      complement(7270..7387)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(7300..7313)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            7469..8632
                     /locus_tag="MF672_RS44255"
                     /old_locus_tag="MF672_044255"
     CDS             7469..8632
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853358.1"
                     /locus_tag="MF672_RS44255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044255"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_242381485.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.1e-48, bitscore:
                     162.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHVVVVGAGLAGVRTVEALRGRGFDGTITLVGRERHRPYDRPPL
                     TKSVLLGESDTTFVDTDLAALRVAFRPGVSATALRPGAVETTEGELRYDGLVIATGADP
                     VRLPGDGPQHVLRTLDDAHELRAALVPGARVAVIGAGWIGAEVATAARRAGCHVTVVEA
                     GPAPLFTAVGAEIGARTERWYDGIDLRLDTMVHSVEEGGVELVGGEFLDAHVVVAGIGV
                     RPAVEWLADADLDLHNGVVVDERLRASLPGTVAVGDCAAWWSRRFQARLRVEHWDTALN
                     APEVAAAALLGEDAVYDPVPYFWSEQFGHMVQYAGHHPAGERLLYRGGPEGKWSAVWLR
                     ADDTLAAVFAVDRPRDLVQGRRLIDAGARLHAERLVDPEVPLRDCVV"
     gene            8663..9040
                     /locus_tag="MF672_RS44260"
                     /old_locus_tag="MF672_044260"
     CDS             8663..9040
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541673.1"
                     /locus_tag="MF672_RS44260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044260"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_242381486.1"
                     /transl_table=11
                     /translation="MTLSVAQIDRETDQLVDEWLTLPEVARRLDLPMGRAKQLLKDHKL
                     LGVRREGSGGPQVPAVFLDGKEVMKGLPGTLTVLQDAGYDDVESLRWLFTPDDSLPGSP
                     IEAIRAGRHTEVKRRAQALAF"
     gene            9018..9656
                     /gene="thiE"
                     /locus_tag="MF672_RS44265"
                     /old_locus_tag="MF672_044265"
     CDS             9018..9656
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541674.1"
                     /locus_tag="MF672_RS44265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044265"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_242381487.1"
                     /transl_table=11
                     /translation="MPRPSLSDARLYLCTGARRDRGDLAQFLDTVLANGVDIIQLREKG
                     LEAREELALLEVFRDACDRHGKLLAVNDRADIAYAARPDVLHLGQDDLPVTVAREILGD
                     DIVIGRSTHSTAEASAAAVEEGVDYFCCGPIWPTPTKPGRPAPGPPLLRHAAGLGTARP
                     WFGIGGIDLGNLDEVLSYGVRRVVVVRAITDADDPGAAAAEFAKRLAAA"
     gene            complement(10001..11071)
                     /locus_tag="MF672_RS44270"
                     /old_locus_tag="MF672_044270"
     CDS             complement(10001..11071)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889490.1"
                     /locus_tag="MF672_RS44270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044270"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_242381488.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5.2e-47, bitscore:
                     157.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSDAVSMDVLRTRVERALGAFVEHRLPAAGDPDFQPLRAAAEDL
                     LAGGKRLRPAFCYWGWRGAGGADDDPGIFTAAASLELLQASALVHDDVMDKSDLRRGMP
                     AAHRRFQAMHEKAAWHGSPEQFGEGAAILLGNLLLIWSGEMWRTSGLPREALEAAQPVH
                     DHMRTELMCGQYLDLLEQAHGENTFDSALRVALYKSGKYSVEQPLRLGLALAARKLTPW
                     MDELCTGYGQRVGIAFQLRDDILGVFGDPAQTGKPAGDDLREGKRTMLVARTLAAASPG
                     AAAAVRRLLGDPRLDEDGVATLRDVIEGTGALRECEELIGVYLGEALDALARAPVTEEA
                     RAALEGLAIAATSRTT"
     gene            11205..12125
                     /gene="metF"
                     /locus_tag="MF672_RS44275"
                     /old_locus_tag="MF672_044275"
     CDS             11205..12125
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889491.1"
                     /locus_tag="MF672_RS44275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044275"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_242381489.1"
                     /transl_table=11
                     /translation="MALGRPSVLPGRVPTVRDMLAAGGRTFSFEFFPPKTDEGERQLWK
                     AIRELESLRPAFVSVTYGAGGSTRDRTVDIVERIAHDTTLTPVAHFTAVNHSVRELRHL
                     VGRFADAGVRNILAVRGDPPGDPAGEWVRHPEGVLYAEELVRLIRQSGDFCVGVAAFPY
                     KHPRSPSIESDTEFFVRKCRAGADYAITQMFFQADDYLRLRDRVAAQGCDTPIIPCIMP
                     VTQMSTIARSEQLSGAPFPPDVAARFEAVKDDPAAVRRLGIDHGAELCQRLLDEGAPGI
                     HFITFNRSSASREVFQRLAPVPLTA"
     gene            complement(12297..12872)
                     /locus_tag="MF672_RS44280"
                     /old_locus_tag="MF672_044280"
     CDS             complement(12297..12872)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541677.1"
                     /locus_tag="MF672_RS44280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044280"
                     /product="N-acetyltransferase"
                     /protein_id="WP_242381490.1"
                     /transl_table=11
                     /translation="MIEFRGAGPAEFTERLETVIGIYTAAMNPPGDQITGRKAIMRNHA
                     TYPHFQCYFAELREPSLTPGDREEPRTVGFAYGFRGAPGQWWHDVVLRALTEQSGRETA
                     QAWLGHAFELAEIHVHPDYQGKGIGRAMIRTLCAGRGERSAVLSTHDRPTAARHLYASL
                     GFTDLLSRFVFPGGYEEYAIAGRPLPLP"
     gene            complement(12882..13358)
                     /locus_tag="MF672_RS44285"
                     /old_locus_tag="MF672_044285"
     CDS             complement(12882..13358)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131598.1"
                     /locus_tag="MF672_RS44285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044285"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_242381491.1"
                     /transl_table=11
                     /translation="MSEKLPPNAVVVQSALRELGAGGEVIVLPEKAPTAATAAAQLGCE
                     VGAIANSLIFDADGEPLLVLTSGAHRVDTGLIARTAGAAKVRRATPEFVRAATGQPIGG
                     VAPVGHPAPVRTLVDNWLSKHEVVWAAGGHPLTVFPTTFDELVRITGGVAVDVE"
     misc_feature    complement(13360..13378)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 16.87"
                     /tool="antismash"
     misc_feature    complement(13405..13423)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(13420..13435)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.67"
                     /tool="antismash"
     gene            13480..14316
                     /locus_tag="MF672_RS44290"
                     /old_locus_tag="MF672_044290"
     CDS             13480..14316
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541679.1"
                     /locus_tag="MF672_RS44290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044290"
                     /product="L,D-transpeptidase family protein"
                     /protein_id="WP_242381492.1"
                     /transl_table=11
                     /translation="MAALLTAGAVALSGCGTTAARPPALPSAAASTQGPAQGPAQAPAA
                     TGGAAAQAGPSATSAAPVAAPRKTLKLGAKGKAVTWMQRRLTELGYRPGKADGRYGGTT
                     LAAVWAFQKVNGIRPTSTIARRTWEALESPKAPKVLVPGGRATRAEVNLTKQIMVLYVG
                     GRPALITHISSGSGVPYCETAVWQGKEQRFCGSASTPTGDYRTTWRASGWHKSYLGELY
                     NPIFFNGGIAFHGALSVPLQPASHGCVRMPMNVAEVLPGMLGKGVPVHVRGRFKGL"
     gene            complement(14357..14761)
                     /locus_tag="MF672_RS44295"
                     /old_locus_tag="MF672_044295"
     CDS             complement(14357..14761)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887922.1"
                     /locus_tag="MF672_RS44295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044295"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_242381493.1"
                     /transl_table=11
                     /translation="MSVAHTDVTAQVSGPCGDEDCGIRDVLDRLGDKWTVLVLVELAKG
                     VRRFRELHRAIPGVSQRMLTVTTRRLCRDGLVERTAYPTIPPQVEYRLTPIGRSLAETV
                     ERLADWSREHRTAMAAARDRWDAEHPGEPG"
     misc_feature    14834..14848
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.07"
                     /tool="antismash"
     gene            14843..>15100
                     /locus_tag="MF672_RS44300"
                     /old_locus_tag="MF672_044300"
                     /pseudo=""
     CDS             14843..>15100
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024852.5"
                     /locus_tag="MF672_RS44300"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044300"
                     /product="NmrA family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MILVTGVSGQLGGAILAGLRAVGGVEAAGASSSAGVADRTADFDR
                     PETLAEAFAGVDVLVFVSAGYAEDDVVLARHGAVVRAAAEA"
     gene            15366..15722
                     /locus_tag="MF672_RS44305"
                     /old_locus_tag="MF672_044305"
     CDS             15366..15722
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MF672_RS44305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MF672_044305"
                     /product="hypothetical protein"
                     /protein_id="WP_247815746.1"
                     /transl_table=11
                     /translation="MAAETQADLAAGVPARHAGRTYELEGVAPVGGPDLAAALAGALGR
                     PVTYRPVPLAAAREGLAGLEPYQAGHSMSIYANMGAGLLEARGGDLGAFLAAPRPVLDV
                     VADTLKAALASAAG"
     gene            complement(15798..16364)
                     /locus_tag="MF672_RS44310"
                     /old_locus_tag="MF672_044310"
     CDS             complement(15798..16364)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MF672_RS44310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MF672_044310"
                     /product="hypothetical protein"
                     /protein_id="WP_247815747.1"
                     /transl_table=11
                     /translation="MGRGRAGRGRRAGVVLLAAGPALVGAYALAGWAAVGQAAEAQVRG
                     PGWEGGRIGPDGLTSLGVDAWRVVALTALVVGVTALAYLAVGPLLGRRSARGRTFLLVL
                     SGFLIVPYALGCVVAFVNAPRLLGRLYQASDFVAGLPGWQPATAFLLPAAGLVQAAGLA
                     LTARRPPRRAPAPSAEPDQARPAAP"
     gene            complement(16454..17107)
                     /locus_tag="MF672_RS44315"
                     /old_locus_tag="MF672_044315"
     CDS             complement(16454..17107)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541681.1"
                     /locus_tag="MF672_RS44315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044315"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_242381200.1"
                     /transl_table=11
                     /translation="MAGLRERKKQRTRRALIEAALRLFDEKGYTDTTLAEIAAAAEVST
                     RTFFSYFAGKEDLVFHDMEERLERALALLESRRPGESVVALLMRLIDAAFEWTLQSGGL
                     TFEEAGLRTRLIMAEPGLRARALLLLYDSQLKLAAALRQACPDELDEVEAAAAVGALFG
                     AVKLAVMAQLGEDRSLGHMHGTARRAAELALDGLRALEARPGVRVHAERPGMAS"
     misc_feature    complement(17143..17159)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.34"
                     /tool="antismash"
     misc_feature    17146..17160
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.77"
                     /tool="antismash"
     misc_feature    complement(17146..17162)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.18"
                     /tool="antismash"
     misc_feature    17146..17162
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 25.39"
                     /tool="antismash"
     gene            17204..18394
                     /locus_tag="MF672_RS44320"
                     /old_locus_tag="MF672_044320"
     CDS             17204..18394
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016712 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, reduced flavin or flavoprotein as one
                     donor, and incorporation of one atom of oxygen [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541682.1"
                     /locus_tag="MF672_RS44320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044320"
                     /product="cytochrome P450"
                     /protein_id="WP_242381199.1"
                     /sec_met_domain="p450 (E-value: 3.6e-17, bitscore: 59.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLTLPMVRQRPLDPPDKIDELRHQAHMHRMTYADGHVGWLVTG
                     YAAARAVLADPRFSNRPEKMHPPLPGRMELLRRQGFKPQPGLFLRTDPPEHTRYRRLLT
                     GQFTVRRMKALEPRIAEITEECLDAMEAAGPPADLVQAFALPIPSLVICELLGVPYEDR
                     ARFQEDARVLFNLEAGLEEALAAIGSTMAYLRDLIGRKRKEPGDDLLSGLVEGGELDDE
                     ELTGVGFLLLIAGHETTANMLGLGTYALLANPGQLALLRADPSLADNAVEELLRYLTII
                     HLGPLRSAEEDVEIEGNLIRAGETVTLSLPAANRDPARFPGGDTLDLTRPATGHLTFGH
                     GIHQCLGQQLARAEMRLAYPALLRRLPGLRLAVTPEEVPMRSDMSIYGVHRLPVTW"
     misc_feature    complement(18401..18415)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.49"
                     /tool="antismash"
     gene            18406..18597
                     /locus_tag="MF672_RS44325"
                     /old_locus_tag="MF672_044325"
     CDS             18406..18597
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017536827.1"
                     /locus_tag="MF672_RS44325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044325"
                     /product="ferredoxin"
                     /protein_id="WP_242381198.1"
                     /transl_table=11
                     /translation="MEIKADTTVCIGAGMCALTAPQLFDQSEDEGTVLVLQREVPAELE
                     DTVRRAVNLCPSGAISAS"
     misc_feature    18696..18711
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.11"
                     /tool="antismash"
     misc_feature    complement(18697..18710)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.74"
                     /tool="antismash"
     misc_feature    complement(18734..18747)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.91"
                     /tool="antismash"
     misc_feature    18737..18752
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 25.32"
                     /tool="antismash"
     misc_feature    complement(18738..18751)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.64"
                     /tool="antismash"
     misc_feature    complement(18964..18979)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.09"
                     /tool="antismash"
     misc_feature    complement(18975..18990)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.97"
                     /tool="antismash"
     gene            19021..19467
                     /locus_tag="MF672_RS44330"
                     /old_locus_tag="MF672_044330"
     CDS             19021..19467
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037499.5"
                     /locus_tag="MF672_RS44330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_044330"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_302893382.1"
                     /transl_table=11
                     /translation="MAPRPRDTPGPRLSPAVRAHLADARSSLAEASAARTPASRYVAAH
                     LAALRAAAAMLAARPRPAESRRRKLRSAWELLPEAEPHLAEWAAYFSVTAAKRAAAEAG
                     MTSRISAADADEILAEADTFVSTVEDLLGVPVQPQLPLNVPLAG"
     gene            complement(19931..20443)
                     /locus_tag="MF672_RS44335"
                     /old_locus_tag="MF672_044335"
     CDS             complement(19931..20443)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MF672_RS44335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MF672_044335"
                     /product="hypothetical protein"
                     /protein_id="WP_242381196.1"
                     /transl_table=11
                     /translation="MKTSRARRGLDVATAIRQIGQQLRFSRTPVRDALVAAGVRSIERG
                     ADGGAARPVRDVGAVDPRPGGALRPQRGQVAGGAGGGRGRGSEDFGAGQIGWCEFPWYS
                     IVAQGDEFMTVWNYRVIFYRDLRVPLQEMCDVQGQEGWELVGVTPHLDKPGFAIDFGLI
                     FKKPAGQ"
ORIGIN
        1 gccggggcgc cgggggcggg cgcggccggc ggcgtcggct tcgcggcgct ggcgttcctg
       61 cacgccgaga tccgccccgg catcgaccac ctgctcgggc tgctcggctt cggcgcggcg
      121 gcggcgggcg cgcggctcgt catcaccggc gagggctccc tggacgagca gtcgctgcgc
      181 ggcaaggccc ccgtcggggt cgcgcaggcc gcggccaggg ccggggtgcc ggtcgtggcc
      241 gtgtgcgggc ggcgcgcgct ctccgacgcc gagctgaagg ccgccgggat cgaggccgcc
      301 tacgccctca ccgacctgga gcccgacccg gcgcggtgca tggccgaggc cgggccgctg
      361 ctggaacgcc tggccgcccg cgtcgccgcc gaccgccacc tcaccgcctg acccgcaccg
      421 cctgacgctc aaccgcccga cgctcaaccg cccgacgctc aaccgcccga cgctcaacca
      481 tccgatgccc gacccggtcg aagggacctc atgacgcagc tcgacctcgt ggtccgctcc
      541 cgccggaccg tcacgcccga aggggagcgg cccgccgcgg tggccgtgcg cggcgagcgc
      601 gtcgaggccc tgcacgccta cgacgcgccc ctcgacgccg ccgaggacgt cgacctccgc
      661 gacctggcgc tgctgcccgg cctggtggac acgcacgtcc acgtcaacga gcccggccgc
      721 acgcactggg aggggttcgc ctcggcgacc agggccgccg cggcgggcgg cgtcaccacc
      781 atcgtcgaca tgccgctcaa ctcgctgccg cccacggtca gcgtggccgc gctggaggcc
      841 aagctggccg cggcgcgcgg gcagtgccac gtggacgtcg ggttctgggg cggggcggtg
      901 ccgggcaacg tcaaggacct ggcgccgctg cgcgagcgcg gcgtgctcgg cttcaagtgc
      961 ttcatgtcgc cgtccggggt cgaggagttc ccgccgctgg agggcggcga gctgcggcgg
     1021 gcgctggagg aggtggccgg gttcggcggg ctcatggtgg tgcacgccga ggacccggcg
     1081 ctgctggccg agccggccgg gccgggctac ccggagttcc tggcctcgcg gcccggggag
     1141 gccgagcgca gcgccgtgcg gcggctggtc gagctgtcca gggagaccgg cgcgcgggtg
     1201 cacgtcctgc acgtctccag cgccgcctgc ctggacgtgc tggcggccgc gcgggcggac
     1261 ggggtgccgg tcaccgccga gacctgcccc cattacctga cgctggcggc cgagcaggtg
     1321 cccgaggggg cgacggcgtt caagtgctgc ccgccgatcc gctccgccgc caaccgcgac
     1381 ctgctgtggg aggggctggc cggcggggtg ctgagctgcg tggtgtcgga ccactcaccc
     1441 tccaccgccg acctcaaggt gcccgacttc gccgccgcct ggggcggcat cgcctcgttg
     1501 cagctcgggc tggccgcggt ctggacggag gccgcccgcc ggggccaccg gctggccgac
     1561 gtggcgcggt ggatggccgc cgcccccgcc gcgctcgcgg gcctgcccgg caagggcgcg
     1621 atcgcgccgg gcaacgacgc cgacctcgtc gccttcgacc cggccgccga caaccccgtg
     1681 gacgccgccc gtctgcacca caagaacccc gtcacgccgt accacgggcg cgtgctcaag
     1741 ggcgcggtgc tcaccacgtg gctgcgcggc cggcccgtgg acggcgtgcc gcacggccga
     1801 ttcctgttgg gagagcagta gatgacccgc ttcaccgagc tgcccgacct cgcgctgcgt
     1861 acccacggcg gggcggtggt ggccgccagc gacgagtcgt tcgccgagaa ggagagcctg
     1921 atccggcccg gccggcccgg cttccgcgcc ggcacgttcg ggcccaaggg gcaggtctac
     1981 gacggctggg agacccggcg gcggcgcgcg cccggccacg actgggcgct ggtgcggctc
     2041 ggggtgccgg gcgtgatccg cggggtggtc gtcgacaccg cctggttcac cggcaactac
     2101 ccgccgcacg cccgggtcga ggcggcctgc gtcgagggcc acccgtcccc ggaggagctg
     2161 ctggccgccg actgggcgga gatcgtgccg aggtcggagc tgaagggcga cgccgagcac
     2221 ctcttccccg tcgccggcgg tgagcgccgc acgcacgtgc ggctcagcat cttcccggac
     2281 ggcggcgtcg cccggctgcg cgtgcacggc gagccccgcc ccgacctgac cccgtacgac
     2341 gggctcggcc tcgacctggc cgcgctcgcc agcggcgggc tggtcaccgc ctgctccgac
     2401 ggcttctact ccgccccgca caacgtcatc gcccccggcc tggcccgcca ccaggcggag
     2461 ggctgggaga cggcgcggcg gcgcgacggc ggcaacgact ggctggtcat ccgcctggcc
     2521 gggcgcggcg tgctccgcct ggccgagatc gacaccacga atctgatctt caacgccccg
     2581 gccgcggtca ccctcaccgg cttcgacggc gagcccggcg ccgccgcccc ggtggagctg
     2641 ctgccgcgca cccgcctgca gcccgacacg ccgcaccgct tccgcctcgg cgccgccgcc
     2701 ggcgtgccgg tcacgcacgt ccgggtggac atccacccgg acggcggcct ggccagggtc
     2761 cgcctccacg gccacctgac gccctgagcg gcgcccccgg gcgtcactcc cggggcgtca
     2821 ctgccagagg tggacggtgc tgcccggcgg gcgctcgctg ctcggcagcg gacgctggaa
     2881 ctgcaccacg ccgcggttgc ccagccggtg gacctccacc ctgaagccca gcgcggccag
     2941 ctcgcgcctg gcgtcctcga cgttcttgcc gatcacctgc ggcaccaggg cgaactgctg
     3001 gtcgtcgcgg gcctggttgt cgccccggcc gaaccagtcc cagaagtcgg tctggcagcg
     3061 cgcgaccgtg accgtgacct gcgcgccccg gtcgacctcg gacttcgcct tcggcacctg
     3121 cgcgatgacg gtgcacggct cggcgtcgtc gtcgatctcc tgcacctgca ccgagaagcc
     3181 ctgctggccg aggtagccgg cggcctcgtc cttcggcatg ccgccgacgt ccggcatcac
     3241 caggccggcg ctgacgaaga tcgagatgcg cgcgccctcc ttgaccttct cgcccacctg
     3301 cggggaggtg cggatcacct tgtcgcgctc gacctcggtg ttgggcagcc gcttgaccga
     3361 gccgacggtc aggccctcct tggcgatcgc ggcgcgggcg tcgttgccgt tcatgccggt
     3421 gacgttgggc accaccacgc gcttggggcc gagcgagggc gtcaacgtga tcgtggcgcc
     3481 ctgctcgacc tcggtgccgg cgagcgggtc ggtggacagg accaggccct cggcggtctt
     3541 ctcgtcgtac tggccctggc cggtcctgat cttgaagccg cccttggcgg cgtcctgctg
     3601 ggccagcgcc atgctcttgc ccaccaggtc ggggacgtgc acgtagtcgg gctgggcgaa
     3661 gaaccagccg gtcagcccga tggcgaccac catgaaggcg gccagcgcca ccaggaacca
     3721 gttgggccgg aacccgcgcc gccgccggcc ggggacctcg gcgcgcggct ggacgagcgt
     3781 gtgcgcgggc gcgacctgcg gcaccgaggg ggcggcgtgc acggcggtgc ggtcgttcgg
     3841 ctgggacggc ggctgcgggc gcaggccggg cgcggacccg gccatcgacc cggccatcga
     3901 cccggccatc ggcacgggcg ccgggccggg cagggaagcg gccgccgggg ccgccatcga
     3961 cccggtgacg ggcgcggaca tcgcgccgga gccgcgcatc ggcccgtacg gccgcgcgtg
     4021 cgacagcggc gggatcgtgg tgcgcggcag catgcggtgc gcgtccacgg ccgccaccag
     4081 cagcgccgtc gcgtccttcg ggcggtcctg gggctcgcgc gccgtggcct gcgccacgag
     4141 cgtgtcgatc agcggcggca cgtcgggcgt cagcgacgac ggcgccggca cggtgtcgtg
     4201 gacgtgccgg taggcgaccg acatgggcgt ctcgccgtcg tagggctgct gcccggtcac
     4261 cagctcgaac agcatgatgc cggccgcgta gacgtcgctg cgcacgtcgg ccgcgcccgt
     4321 gagcacctgc tcgggcgcca tgtagccgat cgtgccgatc atcacgccgg tgcgcgtctg
     4381 gttcgtcgcc tcgatggcct tggccaggcc gaagtccacg accttgaccc ggccgtcgtc
     4441 ggtcatcagc acgttctcgg gcttgacgtc gcggtgcacc atgccggcct ggtgggcggc
     4501 gccgagcgcg gccagcaccg ggatgaggat ctccagcgcc tcgcgggcgg gcagccggcc
     4561 gcgctcgcgc agcacgtcgc ggagcgtgcg gcccggcacg tactccatcg acaggtagac
     4621 gacgtcgttg tcggtgccct ggtcgaagac gtgcacgaca ttggggtggg agagactggc
     4681 caccgacttc gcctcgccga tgaaccgcct gacgaacgcg gggtcctcgg cgagcgagcg
     4741 gtgcatgacc ttcagcgcca ccgtgcggtc gagccgcacg tcgagcgcca ggtagacggt
     4801 cgccataccg ccccgggcga tccggctctc gatgcgatag cgtccatcga ggagccgccc
     4861 gaccagaggg tccgcagtcg tcgtatccac cccgccgagt ttacgggcgt tttggcaccg
     4921 gcagggcccg gccgcccgaa accgatgccg agccgtgccc cctggaacgc accatagtcc
     4981 cgcgggcccc gctgtgtccc acccgtgcca cgaaaggccg ggtcacgggc agggcgcggg
     5041 ggtcacgggg tcgtcatggg gtcacgggtc acggggtcat gggcgaggac gcctcggcgt
     5101 agcggcggcg cgggatgcgc ccggcctgcc gcgccagccg cccggccgac accgccgcct
     5161 tcatcgccgc cgccatcagg tccggccgct gcgcccgggt gaccgccgtg gccagcagca
     5221 ccgcgtcgca gcccagctcc atcgccagcg cggcgtcgct cgccgtgccg atgcccgcgt
     5281 cgaggatcac cggcaccgag gcggcctcga cgatcagctc gatgttgtgc gggttgcgga
     5341 tgccgagccc cgacccgatc ggcgcgccca gcggcatcac cgccgcgcac ccggcctgct
     5401 ccagccgccg ggccagcgcc gggtcgtcgc cgatgtacgg cagcaccacg aacccgtcgg
     5461 cgaccagccg ctcggccgcg tcgaacgtct cgatcgggtc cggcagcagc gtccgctcgt
     5521 cggcgatgac ctcgagcttg acccagttcg tccccagggc ctcgcgggcc agccgggccg
     5581 tcagcacggc ctcgcccgcg gtgaagcagc cggccgtgtt cggcagcacc ttgatgccgc
     5641 gctcgcgcag cacgtccagc accgagccgc gcgccgccgg gtcgagccgc cgcatcgcga
     5701 ccgtggtcag ctcggtgccc gaggccgcga gcgcctggtc gagcacctcc agcgagggcg
     5761 ccccgccggt gcccatgatg agccgggagg cgaacttctc cccggcgatg atcagctcat
     5821 ccaccctgca ccgccgtcag cacctccacg cggtcgctgt cgcgcagcgc cgtggtctcc
     5881 caggcgccgc gcgtgaccac ctcgtcgttc acggccacgg cgaccccggt ggtcgccgtg
     5941 gtcagggccc gtacggcctg cgccacggtc gtgccgtcgg cgagctcgtg cgcggccccg
     6001 ttgatctgga caatcatgcg atctcctgaa ctccccccga ctcgtggaac ctggcgggcg
     6061 agcacaacgc gcccagcgcg tccagctcgg ccgcctcctc gccaccgctc tccccggcga
     6121 ccagggccgc cgtgaggggc gcgagcagca cgccgccccg gtggtgaccg gtggcgagga
     6181 cgagccccgg cgcgcctcca gggccgatga ccggcaggtt gtcgggcgtg cccgggcgca
     6241 ggcccgccac cacgtcggcc agctccagct cggtgacgcc gggcaccagc tccctggcgt
     6301 cgcgcagcag ctcgtacagg ccgcccgccg tcacgcgggt gtcgaagccc agctcctcct
     6361 gggtggcgcc gaccaccagc tcgccgtcgc cccgggggac gaggtagacg gacgagccgt
     6421 ggacggagcc gcgtacgcac cgggtgagca gcggccgcgg cgagcgcagg cgcaggatct
     6481 ggcccttgac cgggcgcacc gggaccccgg ccaggccgcc gctccaggcg ccggccgcga
     6541 gcaccacccg cccggcccgc acctcggacg gccccgcgcc ctcctccagc cgcaccccga
     6601 cgaccctgcc cgcgcccggc ggctccgctc ccgtgtcgtc ctcgcgcagc agcccggtgg
     6661 cgcgggcccg gaccagcggc acccgcagcc gctccagcgc ggccagcagc gccgccgtca
     6721 cccggcgcgg gtccacccag gcgtcaccgg ccgccagcag cccgccgcgc accgacggcg
     6781 ccagcatcgg ctccagccgc cggcactcgc gcccggtcag ccgctcgacc ggcagcccca
     6841 gcttgtccat gaacgcggcc agctcgtcca gcgccgcgag gtcgtcggcc ccgaacgcca
     6901 cgtccagggt cccctccgcg cgcaggtcca ccccgggccc ggtggcgggc aggcccgcgt
     6961 cggcggccag ctcggccgcg aaggccggcc agcggcgcag cgacgccatc ccgagccgca
     7021 gcagcggcgc ctcggtgtag gtgacctcgc tgatcggggc cagcatgccg gccgccgcgt
     7081 gcgaggcccc gcgcgccgga cgcggatcga ccacggccac ccgccgcccg gcccgcgcca
     7141 gccgccacgc cacggacagc ccgacgaccc cgccccccac gaccacgtcg gtgagcccgg
     7201 agagcccgcc gcccgcgccg gagagcccgg cggtcgtagt ggagagcccg gcggctgcgc
     7261 cgcctgcgtt cgcgtccatc gtgcgctccc ttcgccggca tgatccggat caggtgtctt
     7321 gcggtcgaag gcccgctggc agccttcctc tcagcccggt cacggccgga ctcccgcgcg
     7381 tcttacgccc acagcctacg acctcaccgg cgtgtccccg cacgcccccc ttcgccgccg
     7441 ggccgcgcgc ccgtctatgg tcttggtcgt gaaccatgtc gtggtggtgg gagcgggcct
     7501 ggccggcgtg cgcacggtcg aggcgctgcg cgggcgcgga ttcgacggca cgatcaccct
     7561 ggtcggacgg gagcgccacc gcccctacga ccgcccgccc ctgacgaaga gcgtgctgct
     7621 gggcgagtcc gacaccacct tcgtcgacac cgacctcgcc gcgctgcgcg tcgccttccg
     7681 gcccggggtg tccgccaccg cgctgcgccc gggagccgtc gagacgaccg agggcgagct
     7741 gcgctacgac ggcctggtca tcgccaccgg cgccgacccg gtcaggctgc ccggcgacgg
     7801 cccgcaacac gtcctgcgca ccctggacga cgcccacgag ctgcgggccg cgctggtgcc
     7861 cggcgcccgc gtcgcggtca tcggcgcggg gtggatcggc gccgaggtgg cgacggccgc
     7921 ccgccgcgcc ggctgccacg tcaccgtcgt ggaggccggg cccgcgccgc tcttcaccgc
     7981 cgtcggcgcc gagatcggcg cccgcaccga acgctggtac gacggcatcg acctgcgcct
     8041 ggacaccatg gtccactccg tcgaggaggg cggcgtcgag ctggtcggcg gcgagttcct
     8101 ggacgcgcac gtggtcgtcg ccggcatcgg cgtccgcccc gccgtcgagt ggctcgccga
     8161 cgccgacctc gacctgcaca acggcgtcgt cgtggacgag cggctgcgcg cctcgctgcc
     8221 cggcacggtc gcggtgggcg actgcgccgc ctggtggtcg cgccgcttcc aggccaggct
     8281 ccgcgtcgag cactgggaca ccgcgctcaa cgcccccgag gtcgccgccg ccgccctgct
     8341 cggcgaggac gccgtctacg acccggtgcc gtacttctgg tccgagcagt tcgggcacat
     8401 ggtccagtac gcgggccacc acccggccgg cgagcgcctg ctctaccgcg gcggcccgga
     8461 gggcaagtgg tcggccgtct ggctgcgcgc cgacgacacc ctcgccgccg tcttcgccgt
     8521 ggaccgcccc cgggacctcg tccagggccg ccggctcatc gacgcgggcg cccgcctcca
     8581 cgcggaacgc ctggtagatc cagaagtacc cctacgggat tgtgttgttt gagcaagcac
     8641 gccatgtggt agttgtggtt ccgtgacgct ttctgttgca cagatcgacc gggagaccga
     8701 ccaactcgtc gacgagtggc tcaccctccc cgaagtggcc cggcgcctcg accttccgat
     8761 ggggcgggcc aagcaactcc tcaaggacca caagctcctc ggcgtgcgcc gggagggcag
     8821 tggcgggccg caggtgcccg cggtgttcct cgacggaaag gaagtgatga agggcctgcc
     8881 gggcacgctg accgtgctgc aggacgccgg ctacgacgac gtcgagtccc tgcgctggct
     8941 cttcaccccc gacgactcgc tgcccggctc gcccatcgag gcgatcaggg ccggccgtca
     9001 caccgaggtc aagcggcgtg cccaggccct cgctttctga cgcccgcctc tatctctgca
     9061 ccggcgcccg ccgcgaccgc ggcgacctcg cgcagttcct cgacacggtg ctggccaacg
     9121 gcgtggacat catccagctg cgggagaagg gcctggaggc ccgcgaagaa ctcgccctcc
     9181 tcgaagtctt ccgcgacgcc tgcgaccggc acggcaagct gctggcggtc aacgaccggg
     9241 ccgacatcgc ctacgcggcc cgtcccgacg tgctccacct ggggcaggac gaccttccag
     9301 tgacggtcgc gcgagagata ctcggcgacg acatcgtcat cggacggtcc acccactcca
     9361 ccgccgaggc ttccgccgcg gccgtggagg agggcgtcga ctacttctgc tgcgggccga
     9421 tctggcccac gccgaccaag cccggccgtc cggcccccgg cccgccgctg ctgcggcacg
     9481 ccgcggggct gggcacggcg cggccgtggt tcggcatcgg cggcatcgac ctcggcaacc
     9541 tggacgaggt cctgtcgtac ggggtgcgcc gggtcgtggt cgtccgggcg atcaccgacg
     9601 ccgacgaccc gggcgcggcc gcggccgagt tcgccaaacg gctggcggca gcctgaccgg
     9661 agcccccaca gccggtcgca ctccggcccc ccacagccgg ccccaccacg gtcgggcccg
     9721 ccacagtcgg gcccgccaca gccggcccca ccacggtcgg gcccgccggc ccggccaccg
     9781 acccgggcca cggccccatc acaccggccg cactccggcc ggcaccccgc ctctgcccga
     9841 cgcgccgccc cctccctccg gacggggcgg cgctccagtt tttcgcgggg tctggtggtg
     9901 cgggaggcgg cgaccgccag gccggacggg gcggcgcttc agcttggtgg cgcgtgtctg
     9961 gcgatgccgg aagtggcggc ggcggtccag cttgtgcggg tcaggtggtg cgggaggtgg
    10021 cggcgatcgc gaggccctcc agcgccgccc tggcctcctc ggtgaccggg gcccgcgcga
    10081 gggcgtccag cgcctcgccc aggtagacgc cgatcagctc ctcgcactcg cgcagcgccc
    10141 ccgtgccctc gatgacgtcg cgcagcgtcg ccaccccgtc ctcgtccagg cgggggtcgc
    10201 cgagcagccg ccggacggcc gcggccgcgc cgggggaggc ggcggccagg gtgcgggcca
    10261 cgagcatggt gcgcttgccc tcgcgcaggt cgtcgcccgc gggtttgccg gtctgcgccg
    10321 ggtcgccgaa gacgcccagg atgtcgtcgc ggagctggaa ggcgatgccg acgcgctgcc
    10381 cgtagccggt gcacagctcg tccatccagg gcgtgagctt gcgcgcggcg agcgcgaggc
    10441 cgagccgcag cggctgctcc accgagtact tgccgctctt gtacagcgcc acccgcagcg
    10501 ccgagtcgaa cgtgttctcc ccgtgggcct gctccagcag gtcgaggtac tggccgcaca
    10561 tcagctcggt gcgcatgtgg tcgtgcaccg gctgggccgc ctccagcgcc tcgcgcggca
    10621 ggccgctggt gcgccacatc tcgcccgacc agatgagcag caggttgccc agcaggatcg
    10681 ccgcgccctc gccgaactgc tcgggggagc cgtgccaggc cgccttctcg tgcatggcct
    10741 ggaagcggcg gtgcgccgcc ggcatgccgc ggcgcaggtc gctcttgtcc atcacgtcgt
    10801 cgtgcacgag cgcgctggcc tgcagcagct ccagcgaggc cgccgcggtg aagatgccgg
    10861 ggtcgtcgtc cgcgccgccc gcgccgcgcc agccccagta gcagaacgcg ggccgcagcc
    10921 gcttgccgcc cgccagcagg tcctcggcgg cggcgcgcag cggctggaag tcggggtcgc
    10981 cggcggcggg gagccggtgc tcgacgaagg cgcccagggc acgctccacc cgcgtgcgca
    11041 ggacgtccat gctcacggcg tcagaggtca tgcctttgag actagtggcc ggtcggagcg
    11101 cttccgctcg gggccggggt gaggtacgtg aaccccgccg ggccgggcgg gagcggtcgc
    11161 ggcggggcct ccgcgaccgc cgccgctgcc tgtaaccttg ggccatggcg cttggtcgac
    11221 cctccgtcct gcccggacgt gtccccaccg tccgcgacat gctcgccgcc gggggccgca
    11281 cgttctcctt cgagttcttc ccgcccaaga ccgacgaggg cgagcggcag ctctggaagg
    11341 cgatcaggga gctggagtcg ttgcggccgg cgttcgtgtc ggtcacctac ggcgccggcg
    11401 gctccacccg cgaccgcacg gtcgacatcg tcgagcgcat cgcccacgac accacgctca
    11461 ccccggtcgc ccacttcacc gcggtcaacc actcggtgcg cgagctgcgc cacctggtcg
    11521 ggcgcttcgc cgacgcgggc gtgcgcaaca tcctggccgt gcgcggcgac ccgcccggcg
    11581 acccggcggg ggagtgggtc cggcatcccg agggcgtcct gtacgccgag gagctggtgc
    11641 ggctgatccg gcagtcgggc gacttctgcg tgggcgtggc ggcgttcccc tacaagcatc
    11701 cgcgctcgcc gtccatcgag tccgacaccg agttcttcgt gcgcaagtgc cgggccgggg
    11761 ccgactacgc gatcacccag atgttcttcc aggccgacga ctacctgcgg ctgcgcgacc
    11821 gggtggcggc ccagggctgc gacaccccga tcatcccgtg catcatgccg gtgacgcaga
    11881 tgagcacgat cgcgcgctcc gagcagctgt cgggcgcgcc gttcccgccg gacgtggcgg
    11941 cgcgcttcga ggccgtcaag gacgacccgg cggcggtgcg gcggctcggc atcgaccacg
    12001 gcgccgagct gtgccagcgg ctgctggacg agggcgcgcc cggcatccac ttcatcacct
    12061 tcaaccgctc cagcgcctcg cgcgaggtgt tccagcggct cgccccggtc ccgctcaccg
    12121 cctgagcccc ggcaagggcg gccccggcgc gcgtcaaagc cgtcacccgc ccgcaggggg
    12181 accgggcgga tgacggcagg agacacctgt catgccgtaa agggtcggtc actttccgtc
    12241 gtggttcatg cccgcggtca tgacatggca aaccccgcac caggcggagg ccgggctcag
    12301 ggcagcggga gggggcggcc cgcgatggcg tactcctcgt agccgcccgg gaagacgaac
    12361 cgtgacagca ggtcggtgaa gccgaggctg gcgtagaggt ggcgggcggc ggtcggccgg
    12421 tcgtgggtgg acagcaccgc cgagcgctcg ccgcggcccg cgcagagggt cctgatcatg
    12481 gcgcggccga tgcccttgcc ctggtagtcg gggtggacgt ggatctcggc cagctcgaag
    12541 gcgtggccga gccaggcctg ggcggtctcg cggccggact gctcggtgag cgccctgagc
    12601 acgacgtcgt gccaccactg cccgggcgcg ccgcggaagc cgtaggcgaa gccgacggtc
    12661 ctgggctcct cgcggtcgcc aggagtcagc gacggttcac gcaattcggc gaagtagcac
    12721 tgaaaatggg gatatgtcgc gtgattgcgc atgatggcct tgcggccggt gatctggtcc
    12781 ccgggcgggt tcatcgctgc cgtgtagatc ccgatcaccg tctccagccg ctcggtgaac
    12841 tcggccggcc ccgccccgcg aaactcgatc accgtcgcac cctactcgac gtccaccgcg
    12901 acgcccccgg tgatgcgcac cagctcgtcg aacgtcgtcg ggaacaccgt cagcggatgc
    12961 ccgccggccg cccacaccac ctcgtgcttg ctcagccagt tgtccaccag cgtgcgcacc
    13021 ggcgcggggt gcccgaccgg ggccacgccg ccgatgggct gcccggtcgc cgcccgcacg
    13081 aactccggcg tggcccgccg caccttcgcc gcgcccgccg tacgggcgat caggccggtg
    13141 tcgacgcggt gggcgccgct cgtcagcacc agcagcggct caccgtcggc gtcgaagatc
    13201 aggctgttgg cgatggcccc gacctcgcag ccgagctgcg ccgcggcggt cgccgccgtg
    13261 ggcgccttct ccggcagcac gatgacctcg ccgcccgccc ccagctcacg caacgcggac
    13321 tgcacgacga cggcgttagg aggcaacttc tcagacatgg ggacactcta aacaggttga
    13381 cggcttgatt acccgttcgt ggtgactggt gtagtgtcct gtgatccgct gcacacggca
    13441 tgagaggtgg tacgggtggg gttttcgcga ctgcccggaa tggctgctct gctgacggcc
    13501 ggagccgtcg cgctgtccgg ctgcggcacg accgcggcgc gaccaccagc cctgccgtcc
    13561 gccgccgcgt ccactcaggg gcccgctcag gggcccgctc aggcgcccgc cgccaccggc
    13621 ggggccgccg cgcaggcagg cccctccgcc acctccgcgg cccccgtcgc cgcgcctcgt
    13681 aagacgctga agctgggcgc caagggcaag gccgtcacct ggatgcagcg gcggctcacc
    13741 gagctcggct accgccccgg caaggccgac ggccgctacg gcggcaccac cctggcggcg
    13801 gtgtgggcgt tccagaaggt caacggcatc cggcccacca gcacgatcgc caggcgcacc
    13861 tgggaggccc tggagagccc gaaggccccc aaggtcctgg tgcccggcgg cagagcgacc
    13921 cgcgccgagg tcaacctcac caagcagatc atggtcctgt acgtcggcgg ccggccggcg
    13981 ctcatcaccc acatctcctc cggcagcggc gtcccgtact gcgagaccgc ggtgtggcag
    14041 ggcaaggagc agcgtttctg cggctcggcg agcacgccca ccggcgacta ccggaccacc
    14101 tggcgggcga gcggctggca caagtcctac ctgggcgagc tgtacaaccc catcttcttc
    14161 aacggcggca tcgccttcca cggcgcgctg tcggtgccgc tccagccggc ctcgcacggc
    14221 tgcgtccgca tgccgatgaa cgtggccgag gtgctgccgg ggatgctcgg caagggcgtg
    14281 ccggtgcacg tgcggggccg cttcaagggg ctgtgagccc cggggccgac ctcgggtctc
    14341 agcccggctc gcccgctcag cccggctcgc ccgggtgctc ggcgtcccag cggtccctcg
    14401 cggcggccat ggccgtcctg tgctccctcg accagtccgc cagccgctcc accgtctccg
    14461 cgaggctccg gccgatcggc gtcagccggt actccacctg cggcgggatg gtcgggtacg
    14521 ccgtccgctc gaccaggccg tcccggcaca gccgccgggt cgtcaccgtc agcatgcgct
    14581 gggagacgcc cgggatcgcc cggtgcagct ccctgaaccg ccgcacgccc ttggccagct
    14641 cgacgagcac cagcaccgtc cacttgtcgc cgagccggtc gagcacgtcg cggatcccgc
    14701 agtcctcgtc cccgcacggc ccgctgacct gggcggttac gtcggtgtgc gcgactgaca
    14761 tgaaagtgcc tccttatggc ggacgcccgg gtgcgcccat gctggtgacc gtctaaccgg
    14821 gcacaacacc aggagtggtc agatgattct cgtcaccggc gtgtcggggc aactgggcgg
    14881 ggcgatcctc gccgggctgc gggccgtggg cggagtggag gcggccgggg ccagcagctc
    14941 cgcaggcgtc gcggaccgga cggcggactt cgaccgcccg gagacgctcg cggaggcgtt
    15001 cgcgggcgtg gacgtgctgg tcttcgtctc ggccgggtac gccgaggacg acgtcgtgct
    15061 ggcccgccac ggggccgtgg tgcgggcggc cgccgaggca ggggtgcggc acgtggtcta
    15121 cacgagcctc gccgggtcgg gggagcggct gacgctcgcg ctcgcgcacc gctggaccga
    15181 ggcgcggctg gccgaggcgc cgttcggcgt caccgtcctg cgcaacggcc tgtacgccga
    15241 gctcgtggcc gggctggcgc tcgccggggc cgcggcggcg gccgggagcg gggtgttcgc
    15301 ggcgccgctc ggcgacgggc ggctgacggc ggtggcccgc gacgacctgg cggccgtggc
    15361 cgcgcgtggc ggccgagacg caggccgacc tggcggccgg ggtgccggcg cggcacgcgg
    15421 ggcggacgta cgagctggag ggcgtggcgc cggtcggcgg tccggacctg gcggcggcgc
    15481 tggccggcgc gctcggccgg cccgtcacct accggccggt gccgctggcg gcggcgcggg
    15541 aggggctggc ggggctggag ccgtaccagg cggggcacag catgtcgatc tacgcgaaca
    15601 tgggggcggg gctgctggag gcgcgtgggg gcgatctggg cgcgttcctg gccgcgccgc
    15661 ggccggtcct ggacgtcgtc gccgacaccc tgaaggcggc cctggcgtcc gcggcgggtt
    15721 agcgcggggc ggccgggtga gcgcggggcg ggcgttcaga gcgcggcggg gcggccgggt
    15781 gagggcgggg cggccgttca gggcgcggcg gggcgggcct ggtcgggctc ggcggacggg
    15841 gccggtgcgc ggcggggcgg gcggcgggcc gtcagggcca gcccggcggc ctggacgagc
    15901 cccgccgccg gcagcaggaa agccgtggcc ggctgccagc cgggcagccc ggcgacgaag
    15961 tcggacgcct ggtagaggcg gcccagcagc cgcggcgcgt tgacgaaggc gacgacgcac
    16021 cccagcgcgt acggcacgat caggaacccc gacaacacga gcaggaacgt ccgccctcgc
    16081 gccgagcgcc gccccagcag cggcccgacg gccagatagg ccagcgcggt cacccccacc
    16141 accagggccg tcagcgccac cacccgccag gcgtccacgc cgagcgaggt cagcccgtcg
    16201 ggcccgatcc tgccgccctc ccacccgggg ccgcgcacct gcgcctcggc ggcctgcccg
    16261 acggcggccc acccggccag cgcgtacgcc cccacgagcg ccggcccggc cgccagcagc
    16321 accacccccg cccgccgccc ccggcccgca cgcccccggc ccacacgccc ctgcccgccc
    16381 ctgtgctcag ccccggccgg tcgccctcac ccgccacgcg cacccccaca ccacgtccct
    16441 tgaggatccc gggtcagctt gccatccccg gccgctcggc gtggacgcgg acgcccggcc
    16501 gcgcctccag cgcgcgcagc ccgtccagcg ccagctcggc cgcgcgccgg gcggtgccgt
    16561 gcatgtgccc cagcgaccgg tcctcgccga gctgggccat cacggccagc ttgaccgccc
    16621 cgaacagcgc gcccaccgcg gccgccgcct cgacctcgtc cagctcgtcg gggcacgcct
    16681 ggcgcagggc cgccgccagc ttgagctggc tgtcgtagag cagcagcagc gcccgcgccc
    16741 gcagcccggg ctcggccatg atgagccgcg tccgcagccc cgcctcctcg aacgtcagcc
    16801 ccccggactg cagcgtccac tcgaaggccg cgtcgatgag ccgcatcagc agcgcgacga
    16861 cggactcgcc ggggcggcgg ctctccagca gcgccagcgc ccgctccagc cgctcctcca
    16921 tgtcgtggaa gaccaggtcc tccttgccgg cgaagtaact gaagaacgtc cgtgtggaca
    16981 cctccgccgc ggcggcgatc tccgcgaggg tggtgtcggt gtagcccttc tcgtcgaaca
    17041 gccggagcgc cgcctcgatc agcgcccggc gcgtgcgctg cttcttacgc tcccgcagtc
    17101 ctgccatggg cgaactttac tgcatgtcca gctttctttc atcggttgta attttgcaac
    17161 cgatgaggtt ttctggacgt acgtcccgga gaggagccga ggcatgtccg atctgaccct
    17221 tcccatggtg cggcagcgcc cgctggaccc gcccgacaag atcgacgaac tgcggcacca
    17281 ggcccacatg caccgcatga cgtacgccga cggccacgtg ggctggctcg tcaccggcta
    17341 cgccgccgcc cgcgcggtgc tggccgaccc ccgtttctcc aaccgcccgg agaagatgca
    17401 cccgccgctc cccggccgga tggagctgct caggcggcag ggcttcaagc cgcagcccgg
    17461 cctgttcctg cgtaccgacc cgcccgagca cacccgctac cgcaggctgc tcaccggcca
    17521 gttcaccgtg cgcaggatga aggcgctgga gccgaggatc gccgagatca ccgaggagtg
    17581 cctggacgcc atggaggccg cggggccgcc cgccgacctg gtgcaggcgt tcgcgctgcc
    17641 catcccgtcc ctggtgatct gcgagctgct cggcgtgccg tacgaggacc gcgcccgctt
    17701 ccaggaggac gcgcgggtgc tgttcaacct ggaggccggg ctcgaggagg cgctggccgc
    17761 catcggcagc acgatggcgt acctgcgcga cctcatcggc cgcaagcgca aggagccggg
    17821 cgacgacctg ctgagcgggc tcgtcgaggg cggcgagctg gacgacgagg agctgaccgg
    17881 cgtcgggttc ctgctgctca tcgccgggca cgagaccacc gccaacatgc tcgggctcgg
    17941 gacgtacgcg ctgctcgcca accccggcca gctcgcgctg ctgcgcgccg acccctcgct
    18001 cgcggacaac gccgtcgagg agctgctgcg ctacctcacc atcatccatc tggggccgct
    18061 gcgcagcgcc gaggaggacg tcgagatcga gggcaacctc atcagggcgg gggagacggt
    18121 cacgctcagc ctgcccgcgg ccaaccgcga ccccgcccgc ttccccggcg gcgacaccct
    18181 cgacctgacc cggcccgcga ccggccacct caccttcggc cacggcatcc accagtgcct
    18241 cggccagcag ctcgcccggg cggagatgcg cctcgcctac cccgcgctgc tgcgccgcct
    18301 gcctggccta cgcttggccg taacgccgga ggaggtgccg atgcgctcgg acatgtcgat
    18361 ctacggagtg caccgcctcc ctgtcacctg gtagaggtca tcaacatgga aatcaaggca
    18421 gacacgaccg tgtgcatcgg ggcgggaatg tgcgcgctga cggcgcccca gctgttcgac
    18481 cagagcgagg acgagggcac ggtgctggtc ctgcagcgcg aggtgccggc cgagctggag
    18541 gacaccgtgc ggcgcgcggt caacctgtgc ccgtcgggag ccatctccgc ctcctgaccc
    18601 cgcccccgtc cccttccccg ttcgagccgc cgccgccgcg acacgccgtc gcggcggcgg
    18661 cttccgcctg ttcggagcgt ttctcttcaa ggtcatcgaa cctgtgttcg tggaaccggt
    18721 tgacaccgga gggtgatcga aattatgttc gacctagtgg cggtgaggct cgcggctcag
    18781 cgtcacgcgg acctggtcgc ggggtgatcg cttccccgag cgtgacccgc ggcgaggctc
    18841 cacgggcgaa gggcacgtcc tcgtcgtcgg cggagacgag cgggcgtgtc ctggccggac
    18901 ggggagaggg gaagctcctc gtccggccgg cccggcggaa atgtcggtgg cgtctgcgat
    18961 tgttggacct accggtgaag aaagccggca gccgcccacg acttcgagga ggcgcgcaag
    19021 atggcaccaa ggcctagaga cacgcccggg ccccggctgt cgcctgcggt tcgggcgcac
    19081 ctggccgacg cacgttccag cctggcggag gcgagcgccg ctcgcacccc ggcttcccga
    19141 tatgtggccg cgcacctggc ggccctgaga gcggccgcgg cgatgctcgc cgcccgtccc
    19201 cgtcccgccg agagccgccg gcgcaagctg cgcagcgcct gggagctgct gcccgaggcg
    19261 gagccccacc tggccgagtg ggccgcctac ttctcggtga ccgccgccaa gcgggccgcc
    19321 gcggaggcgg gcatgaccag ccgcatcagc gcggccgacg ccgacgagat cctggccgag
    19381 gccgacacct tcgtctcgac cgtcgaagac ctgctggggg ttcccgtcca gccccaacta
    19441 ccactgaacg tcccgctcgc cggatgaaga gctgatccgg ccgtccccgg cgacgagaac
    19501 gggacgtccg agaccgcctg acccgtcggc ggtgcacgac ccgacgcggc tcccgcgcac
    19561 gccccggtag gcgcgccgcg acccgatcgg gagcacgctg agctccctga tcgtgaactt
    19621 gcgcatgggc gtgagcaagc ccatgaggat tgagcccgcc gccacctggg cgatcgtgac
    19681 gccgagccgc acgccgtggg cgcatctcag ggcctcacgc tgcgaagcag cccgccgacg
    19741 cgcagcggcc tccttgcgat caccacagcg gccccaaccc cgtcagcccg aacgacaccc
    19801 gcggcgacgc cccgagcagc cacgaaccca ggcactcgtc cagcaacggc ccggacgagg
    19861 cccgggcgcg tggattgacg gcccaggacg cgatcgagcc acgacgcctc gatcggcaca
    19921 tggccgaggg ctactgccct gccggcttct tgaagatcag gccgaaatct atggcgaacc
    19981 cgggcttgtc gagatgggga gtgacgccga ccagttccca cccctcctgt ccctgcacat
    20041 cgcacatctc ctgaagcggc acgcgaagat cccggtagaa gatcaccctg tagttccaca
    20101 ctgtcatgaa ctcatctccc tgtgcgacga tcgagtacca gggaaactca caccagccga
    20161 tttggccagc gccgaaatcc tccgaaccgc gtccccgccc ccctccagcg ccgcccgcaa
    20221 cctgaccacg ctgcggccga agcgcgccgc cagggcgcgg atcgactgcg ccgacatccc
    20281 gtaccgggcg cgcagcaccg ccgtccgctc cccgctcgat actccgcacc ccagcggcga
    20341 cgagcgcgtc acgcaccggt gtgcgggaga agcggagctg ctgcccgatc tggcgtatgg
    20401 cggtggccac gtccaggccc cgccgagcac gggaggtctt cacgccgggc accgtccaag
    20461 acgacggctc agcgcgacgc tgggcaggaa gggccacgat ggcgcatgac ggcttcgcac
    20521 gtcggctcag ggtgaggcga cggtgcgggc gtggccgtcg cggtcggtgg ctctcaggcg
    20581 cgcacgaggc cagccgcgaa ggccggactc gggaggccac tcggaaaggc cggactgcaa
    20641 ggccacgctg agaggccctg tctgcgaccg cgggatcgga ggcccgcacc gcggacactc
    20701 aggctcgcgg gcgctggtga gaggggccgc catgccgttg gggagccggc gagcgcaggc
    20761 ccggcgagcc acaggcggcg atggccgcaa cggtggccag gccggcatcg gcgggtccgg
    20821 ctctcggcgg ggcgcgagcc gccgagccct cggacggccg gagggcgtgc ggtgtgcggt
    20881 tccgcgcccc agggcccagg ccccgctcac agggcttcgg gcccctggcc caggattcga
    20941 gctcacgccc gcgaggcgag cccggaggca tggcccgacg ccgggcgtag gcggtcgccg
    21001 acgcggctcc aggggccggc gcggcgcgtc aaggggccgt ggtgcggggc catcccgatg
    21061 gggcgtcaag g
//
