LOCUS       NZ_JAKRKC020000002     21023 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Actinomadura luzonensis strain ATCC 31491 Contig00006, whole genome
            shotgun sequence.
ACCESSION   NZ_JAKRKC020000002
VERSION     NZ_JAKRKC020000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura luzonensis
  ORGANISM  Actinomadura luzonensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Genome draft of Actinomadura sp. ATCC 31491
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Genome draft of Actinomadura sp. ATCC 31491
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
REFERENCE   4  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
REFERENCE   5  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
REFERENCE   6  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. v1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 89.6x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022664455.2-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 18:46:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,232
            CDSs (total)                      :: 10,155
            Genes (coding)                    :: 10,004
            CDSs (with protein)               :: 10,004
            Genes (RNA)                       :: 77
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 151
            CDSs (without protein)            :: 151
            Pseudo Genes (ambiguous residues) :: 0 of 151
            Pseudo Genes (frameshifted)       :: 36 of 151
            Pseudo Genes (incomplete)         :: 126 of 151
            Pseudo Genes (internal stop)      :: 3 of 151
            Pseudo Genes (multiple problems)  :: 14 of 151
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:31:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2789003
            Orig. end                         :: 2810026
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAKRKC020000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21023
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="7"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21023
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21023
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11023](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11023)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(308..322)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.74"
                     /tool="antismash"
     gene            complement(782..1390)
                     /locus_tag="MF672_RS43275"
                     /old_locus_tag="MF672_043275"
     CDS             complement(782..1390)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024854.5"
                     /locus_tag="MF672_RS43275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043275"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_242377174.1"
                     /transl_table=11
                     /translation="MAEERQATTPSRRPGTTPHEADAAASRTADDAASHEADAAASRTA
                     DDAASYAADDARYVADAADDVRADIGSWPVGRLLSVAARLVERRFHDFLAAHHLSHAGL
                     IALHHLTSGPLPQRELATACRVTDQTMSRTIEHLRRTGYIAKRSDARDRRRMLVELTDA
                     GTAVLALAREKERDSGDLLGAVEDYDRFREDLIRLITIA"
     gene            complement(1395..2405)
                     /locus_tag="MF672_RS43280"
                     /old_locus_tag="MF672_043280"
     CDS             complement(1395..2405)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541530.1"
                     /locus_tag="MF672_RS43280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043280"
                     /product="hypothetical protein"
                     /protein_id="WP_242377172.1"
                     /transl_table=11
                     /translation="MLKDVRAGRVLAAGVAASVVLTGLVWLLGRRLSGIELLPDQGASW
                     YYWKLPEPTFWTRASAWACYAAHQVIFWWLIHRARTRVRRYTSGLHRLNVAALAVNTGF
                     IALHEVQTQLFYDGLAQDVSIFSSQGSVILLLVAVLLMENRRRGLFLGRPAPIRQELVA
                     FARRYHGYLFSWAAVYTFWYHPMENTSGHLIGFLYMFLLLLQGSLFLTRAHTNRWWTVT
                     LELAVAAHGTLVAVMNSGPDGMWPMFLFGFLGVFVVTQMHGLGLGRGVRWALGLAYAAG
                     ALAVYGLRGDLAGVSAVVRIPAIEYALVGVLALLLWLGLRAARLARPREPARLEE"
     misc_feature    2403..2418
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.4"
                     /tool="antismash"
     misc_feature    2408..2422
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.65"
                     /tool="antismash"
     gene            complement(2445..4220)
                     /locus_tag="MF672_RS43285"
                     /old_locus_tag="MF672_043285"
     CDS             complement(2445..4220)
                     /EC_number="6.3.5.1"
                     /GO_function="GO:0003952 - NAD+ synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541531.1"
                     /locus_tag="MF672_RS43285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043285"
                     /product="NAD+ synthase"
                     /protein_id="WP_242377169.1"
                     /transl_table=11
                     /translation="MAQLRIALAQTNPTVGDLSANADRLVAWTRDAAERGAHLVVFTEM
                     FLTGYPVEDLVLRTSFVDAGIRTLEQVARRLAEEGLGELPVVAGYVDRAGLAPRVGQPK
                     GAPLDAAALLYQGEVVARTAKHHLPNYGVFDEYRYFVRGDRLPIFRLHGVDVAVAVCED
                     LWQEGGPVSVVGQAGAGLLVVPNASPYEKEKDDVRLELCARRAREAGCALVYVNQVGGQ
                     DELVFDGDSIVVDGAGELVARAGQFREELLVVDLTGLPVSEAAPGAFPYDAGDGTTITV
                     DRLVLSGEPVAPYPAEPAPVAERLDLHAEVYSALVLAVRDYVAKNGFRSVILGLSGGID
                     SALTATIAADAVGPDRVNVVLMPSRYSSEHSLTDAEELVRRQGVRSQVAPIADIVTAFE
                     KEIELSGLAAENLQARVRGTILMGLSNQNGHLVLTTGNKSELATGYSTLYGDSAGGFAP
                     IKDVPKTMVWELARWRNAHTCAGFLLEAERPIPENSISKEPSAELRPDQRDTDSLPPYE
                     VLDRLLDDYVEKDMGSQELIAAGHDPELVTRVIRLVDLAEYKRRQYPPGPKITPKNFGR
                     DRRLPITNRWRESTS"
     misc_feature    4243..4256
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.01"
                     /tool="antismash"
     misc_feature    4244..4257
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.63"
                     /tool="antismash"
     misc_feature    complement(4245..4258)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.71"
                     /tool="antismash"
     misc_feature    complement(4247..4267)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: medium, score: 30.4"
                     /tool="antismash"
     gene            complement(4253..5770)
                     /locus_tag="MF672_RS51905"
     CDS             complement(4253..5770)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541532.1"
                     /locus_tag="MF672_RS51905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_308210638.1"
                     /transl_table=11
                     /translation="MLTFTALGPFQAWADGAPLDLGGQRQRAVLARLLVAGGRAVPVNT
                     LIDELWPGDPPAQALSTIQGYVSRLRRALEPGRAPREEAEVLVTAPPGYALRAETGQVD
                     AWRFEGLVKSDGPPGQVWADMEAALGLWRGPALAEFADLSWAVTEAGRLEELRLIAVER
                     RADAGLTLGRATSLVADLEAHAAEHPLREEAWRLLAVALYRMGRQGDALAALRRARAVW
                     RDELGLDLTAGLKRLEADMLAQRLEEPPAPEAPAVVPAVVPAAQSAAQPAAPSAPASPG
                     GVLRVLVADDQALVRAGVKAMLDSDPGVTWAGEATNGEEAIAAVPAVRPDVVLLDIQMP
                     RLDGLAAARRILAEERPPRVVMMTTFGSDENLYAALRAGVSGFLLKTAAPEQFLAAIRA
                     AAAGDALIDPAMTTRLISAFAGRTDPASPPALAGLSDALLDVLKLVARGLTNRQIGQTL
                     SLPEEEVGLLVKALLEHLGLFDRAQLVMAAYESGLVTPGEKAHFSSL"
     gene            complement(5820..7649)
                     /locus_tag="MF672_RS43300"
                     /old_locus_tag="MF672_043300"
     CDS             complement(5820..7649)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543588.1"
                     /locus_tag="MF672_RS43300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043300"
                     /product="sensor histidine kinase"
                     /protein_id="WP_242377166.1"
                     /transl_table=11
                     /translation="MRRASLARGTAIAIATLAVTLELADIWVTAQLPPSPLTPLPFAPE
                     DVAGTAFPVFGAILVHSRPRLVIGWLLCAGGLSAAIGVLAANLGELSGAGLPWLVTLSR
                     QVLELTLGVLLPLLYPAGALPSRRWRPVVWLALAGAALEWAGLAPAARWTAGAAMALAF
                     ASLVVRFARGGAVERRQLLWLLVALPGLLVPWIAGGAAAWTASLAIPLIPAAIAVAVLR
                     YRLFGIDTLISRALVGTGLAIVITGVYVAAGAAAGLFLSEVDPVAGIAAAIFAGAFFHP
                     MRRGLQRGVDRLLYGSTGVPEALAARLRHRLQHADPLHGLLATLDVLREGLSATGAAVE
                     VDGDVTASGTMGAAPARTVPLVWHGEPVGRLLIGPPGRRRFPAAHDERVVATLVPYVAD
                     AAHAVRMTAALRRSRERILTAREEERRRLRRDLHDGLGQSLTGMAMSINAARRTARTSP
                     GDAERLLAGLNAGMEAVRADIRELVYGLRPPALDELGLAGAVEELAGTPVEVSGELAGL
                     PAAAEVAAYRIVQEALTNARKHARATRVAVALRREGALLRVTVTDDGVGLSPDARPGVG
                     LHSMRERTAELGGTCAVRDAEGGGTVVQAELPL"
     misc_feature    7688..7708
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.73"
                     /tool="antismash"
     misc_feature    complement(7717..7731)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.45"
                     /tool="antismash"
     gene            complement(7744..8946)
                     /locus_tag="MF672_RS43305"
                     /old_locus_tag="MF672_043305"
     CDS             complement(7744..8946)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541533.1"
                     /locus_tag="MF672_RS43305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043305"
                     /product="MFS transporter"
                     /protein_id="WP_242377164.1"
                     /transl_table=11
                     /translation="MSSPTVEKPPSFLRAQVAGLPRPFWALWGGTVVNRLGTMVMPFTG
                     VYLTQSRGLSVAAAGLVMGVFGAGSLLSQPLAGTLADRIGRRATLSGGMLATAAALLAL
                     GYSATLPAILASMLVLGVVMDLYRPASSAMVADLVPPGERPRAYGLLFWGINLGYSVGM
                     TAGGWLAGMGFLWLFWIDAVSSVVFAVLVWRAVPETRPEGARESAGGFGAVLRDRVMVA
                     FTLVVLGNALVYAQTMTMLPVAMTKVAGLSAAQYGLAMALNGVLIVVVQPLVSGWLGRR
                     DPSRTFALGLAVMGAGFALTGYVTSTLGLAVTVAVWTAGEIVTAGIAGGIVAALAPAHL
                     RGRYAGLFGLAWSAAAALAPLLGGPLLELGPRVLWWTIGAIGVVSAAGMVALGPAIRRR
                     A"
     misc_feature    complement(8998..9012)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.1"
                     /tool="antismash"
     gene            9006..9968
                     /locus_tag="MF672_RS43310"
                     /old_locus_tag="MF672_043310"
     CDS             9006..9968
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541534.1"
                     /locus_tag="MF672_RS43310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043310"
                     /product="DUF5937 family protein"
                     /protein_id="WP_242377162.1"
                     /transl_table=11
                     /translation="MSITWVLRPDDVARIRFAFSPMWELVASLRTLRRPARQSLHLPWI
                     KAVRPRLAGLDLAELMALVPAIGYLADFLTPPPDTPLPDFAAELERVRRTPPERAREEA
                     LRVTGTDPALLRRFAADPAAGVTRVADALEAYWDRCFAEFWPRVYALLERDVLRRSRQL
                     AQGGASELFAALDPAVTWTGERLVVDRPWCAQEGLHGDGLVLVPTAFHWPSVAVMSAPY
                     QSMLVYPVLGVGTLWEEGPPPAPGALAALLGRSRARILLALAEPVTTSALAARMSLTPG
                     AVSQHLGVLSDGGLAVGMRVGKQVLYRRTLAGDMLAGQG"
     gene            complement(10001..11023)
                     /locus_tag="MF672_RS43315"
                     /old_locus_tag="MF672_043315"
     CDS             complement(10001..11023)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541535.1"
                     /locus_tag="MF672_RS43315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043315"
                     /product="terpene synthase family protein"
                     /protein_id="WP_242377160.1"
                     /sec_met_domain="T1TS (E-value: 5e-51, bitscore: 171.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTTDEPGGAADGHSTVTATMFATVRTALRSVLSSMMPLPRRGGS
                     AALALMPLTERVPAMAEPCRMHPAVYAIEAAVIDWARRTGLRADPGVGFHRMAGRAFAE
                     FDAAAAALFAQWLTWLFHLDDELDEGECRLEVFQGLLQGGARHPLEAAFADLWRVTSAR
                     MSDRWRARFAVGLQRQHDACRTEADNRAAGRMPTLEEYPALRRGTVGPYLYDLVEPCLR
                     VEVPAWMHASEPWQQLVDACSDVTAWCNDVASRPKERGDVHNFVVLAMRQLGLGEREAT
                     AWVLDRIARRCEDMHKAARRLPLHDLAPKAARDVSKVACAYLAAPRAHLDWLLESARYA
                     "
     gene            complement(11044..11589)
                     /locus_tag="MF672_RS43320"
                     /old_locus_tag="MF672_043320"
     CDS             complement(11044..11589)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541536.1"
                     /locus_tag="MF672_RS43320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043320"
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_242377158.1"
                     /transl_table=11
                     /translation="MAIDLLNHKLDRAFDHIDANGNGVVERADLLGLGARILVGFGESP
                     TSVTGASLVESFDGIWATLARTLERDGDSGIARPDFRTAMTAAFVTGGHYDPVFRPATV
                     AVAELCDGDRDGEISPGEFRTMLSAFGVAYDDVDEAFDRLDRAGRGRLTVAGLVAAAAD
                     FYRSADPNAPGNWLFGPL"
     misc_feature    11546..11561
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.03"
                     /tool="antismash"
     gene            11776..13137
                     /locus_tag="MF672_RS43325"
                     /old_locus_tag="MF672_043325"
     CDS             11776..13137
                     /EC_number="6.3.1.-"
                     /GO_function="GO:0004356 - glutamine synthetase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013151975.1"
                     /locus_tag="MF672_RS43325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043325"
                     /product="glutamine synthetase family protein"
                     /protein_id="WP_242377156.1"
                     /transl_table=11
                     /translation="MDRQQEFVLRTLEERDIRFIRLWFTDVLGFLKSVAIAPAELEGAF
                     AEGIGFDGSAIEGFARVYESDMLAKPDPATFQILPWRSETPGAGRIFCDILMPDGSPSH
                     ADPRWVLKRTLAKCADMGFTFYTHPEIEFFLLKNRPEPGQRPEPIDSGGYFDHTPHSSG
                     HDFRRQAIMMLESMGISVEFSHHEGAPGQQEIDLRYADALTTADNIMTFRLVMKEVALE
                     QGIWASFMPKPFTEHPGSGMHTHMSLFEGDRNAFYEAGSDYRLSKVGRSFIAGLLRHAA
                     EITAITNQWVNSYKRLWGGAEAIAGQGGEAPSYVCWGHNNRSALVRVPMYKPHKGGSTR
                     IEFRSLDSACNPYLAFALILAAGLKGIEEGYELPPAAEDNVWTLTSAERRALGIEPLPG
                     SLNDAIEVMERSELVAETLGEHVFDFFLRNKRSEWREYRRHVTEFELGRYLPIL"
     gene            complement(13200..15137)
                     /locus_tag="MF672_RS43330"
                     /old_locus_tag="MF672_043330"
     CDS             complement(13200..15137)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.5"
                     /locus_tag="MF672_RS43330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043330"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_242377154.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 4.7e-44, bitscore:
                     148.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRSLLAGASVLAVTTTAALAAAAPAQAAAGDPEVAKSVTAEVR
                     SGHKVRAIIELKKGQSVGAVAKDTEDASKGVQVVDKKLSDDFLVATLDKATLEEVRTDD
                     RVAAVYEDRLSLPSLDVSTKLIGSDKANEAGWTGKGSTIAVLDTGIDRDHPFFAGRIVA
                     EACFSATSTDPYYGAVPLCPNGQSVQVGAGAADAETAACVVNGKNQCYHGTHVAGIAAG
                     KKAAGAPSNGVAPEAGILPIQVFTRLNGAVCQEELGVAAPCFATFVSAQKAALQYVDSV
                     HAGQNVIAANMSLGGGPKQTQPCDDDPSAGALKEEIVWLKQFGVSVVVAAGNNGFTDGV
                     SSPACVSAAVTVGATDDNDAVASFSNRGRLLDLFAPGVQINSSVPGGGYGVLNGTSMAA
                     PHVAGALALIRQAYPQLSDAGRVAKLQDTGKAITYGGVTTKRIDLTAALPPKATPTPTP
                     TATPTATPTATPTTTATPRPTGSHSPSPTPTSSPDDHSTNVDPGIYGDPQPVPDTCSRG
                     KGTKPLSAKAWAREMLRGKGSLSDDTLRCYLTLAQNGSKVFPELTDAGTLTKAYKVLAT
                     RSKAAKALLDRELLASWLNYAHGVYNSSAKVHGATTFKTSVAAAERHRAGKSGAAMKKA
                     AVYLYRHVNK"
     gene            complement(15304..15930)
                     /locus_tag="MF672_RS43335"
                     /old_locus_tag="MF672_043335"
     CDS             complement(15304..15930)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541539.1"
                     /locus_tag="MF672_RS43335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043335"
                     /product="AAA family ATPase"
                     /protein_id="WP_242377244.1"
                     /transl_table=11
                     /translation="MLDEGARTGTVRYPPGSLVILTGLPGAGKTTLLRRLYALDGAESL
                     PVAREAVTVIDTYQAKRHWAGRLAWAPHPVRRAVVFATHLSRISRALADGRSVVAHNRG
                     CAPSVLRGLDWLARRHGARLHLLLLDTTPEAALAGQRERGRVVAARTFARHRRRWEELM
                     ARVRNGDPAPAAAARVVDRGTAALLEAILFEADQDPVSGGFPITE"
     misc_feature    15892..15905
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.83"
                     /tool="antismash"
     misc_feature    complement(16104..16117)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    complement(16138..16153)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.71"
                     /tool="antismash"
     gene            16372..17085
                     /locus_tag="MF672_RS43340"
                     /old_locus_tag="MF672_043340"
     CDS             16372..17085
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541540.1"
                     /locus_tag="MF672_RS43340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043340"
                     /product="PaaI family thioesterase"
                     /protein_id="WP_242377152.1"
                     /transl_table=11
                     /translation="MTTAALQTVLTVPRRFRGPEGVANGGWIAGTMAETLNGGRSAVEV
                     TLHAPTPLETELRLEHMANSASLSHGDRLLVEAIPVAEDLEGPGFVPFNDAARAEAGFA
                     GLKAHPFAECFACGLREPGDGLRIFPGPVAGTDLVAAGWRVPFTVAGEDGVPASIIGAV
                     LDCITGWAHFGPGESALLGRLAVQIHRDVHPGGRYSVVARPTGRDGRKMFGQSAIYEVD
                     GTLVAAGRATWIAPR"
     gene            complement(17147..18001)
                     /locus_tag="MF672_RS43345"
                     /old_locus_tag="MF672_043345"
     CDS             complement(17147..18001)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-270). E-value:
                     4.3e-16. Score: 51.2. Matches aSDomain:
                     nrpspksdomains_MF672_RS43345_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541541.1"
                     /locus_tag="MF672_RS43345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043345"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_242377150.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.8e-17, bitscore:
                     60.1, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 2.3e-12, bitscore: 44.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFHFEDVNGLRVARAGTGPRLIIAVHGITASLMAWGAVARRLPA
                     GWTLVAMDLRGRGHSAGLPGPYGLPRHAEDVLRVAEHVGATGDTVLTGHSMGAYVAALA
                     AARRDFARVVLVDGGIPFPPLPEGVDPDEALAAALGPALDRLRRTYPSAEAYVDFFRAH
                     PAFRGRWSDDVERYVRYDLTGPDGALRSRAVAAAVLEDGRWLHTAQAEAAAALEAVKSP
                     LRLLRAPRGLLDQDTGMLPDDLVAPWTARLPGLRDEVVPDCNHYTILFGERPVATVVDR
                     LTS"
     aSDomain        complement(17192..17938)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MF672_RS43345_Abhydrolase_1.1"
                     /evalue="4.30E-16"
                     /label="MF672_RS43345_Abhydrolase_1.1"
                     /locus_tag="MF672_RS43345"
                     /protein_end="270"
                     /protein_start="21"
                     /score="51.2"
                     /tool="antismash"
                     /translation="LIIAVHGITASLMAWGAVARRLPAGWTLVAMDLRGRGHSAGLPGP
                     YGLPRHAEDVLRVAEHVGATGDTVLTGHSMGAYVAALAAARRDFARVVLVDGGIPFPPL
                     PEGVDPDEALAAALGPALDRLRRTYPSAEAYVDFFRAHPAFRGRWSDDVERYVRYDLTG
                     PDGALRSRAVAAAVLEDGRWLHTAQAEAAAALEAVKSPLRLLRAPRGLLDQDTGMLPDD
                     LVAPWTARLPGLRDEVVPDCNHYTILF"
     CDS_motif       complement(17681..17743)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_MF672_RS43345_0001"
                     /evalue="5.40E-04"
                     /label="NRPS-te1"
                     /locus_tag="MF672_RS43345"
                     /protein_end="107"
                     /protein_start="86"
                     /score="12.6"
                     /tool="antismash"
                     /translation="GDTVLTGHSMGAYVAALAAAR"
     misc_feature    18066..18079
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.84"
                     /tool="antismash"
     misc_feature    18078..18093
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.33"
                     /tool="antismash"
     gene            18079..18762
                     /locus_tag="MF672_RS43350"
                     /old_locus_tag="MF672_043350"
     CDS             18079..18762
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249: carbamoyl phosphate synthase small subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541542.1"
                     /locus_tag="MF672_RS43350"
                     /note="Members of this family of hydrolases with an active
                     site Cys residue belong to MEROPS family C26; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="MF672_043350"
                     /product="type 1 glutamine amidotransferase"
                     /protein_id="WP_242377148.1"
                     /transl_table=11
                     /translation="MRITVIEHEAEAGLGYLAGWLGLACDVVRPYLGEEVPARAADALI
                     VLGGAAAAWEDERSPWQPATRDLLRRAVDEATPTLGICLGAQLLTLACGGVVERGANGL
                     EIGARAVTALPAAREDRLLAGVETAVAVQYHQDAITVLPDGAVPLMTGGQYPNQAYRLG
                     EAAWAVQFHPEATPEIFASWTHGSDLDAAEDLNREVKAAEPALVATWRPVARAFADVIR
                     TAARG"
     misc_feature    18085..18099
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            complement(18740..19333)
                     /locus_tag="MF672_RS43355"
                     /old_locus_tag="MF672_043355"
     CDS             complement(18740..19333)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541543.1"
                     /locus_tag="MF672_RS43355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_043355"
                     /product="HXXEE domain-containing protein"
                     /protein_id="WP_247815727.1"
                     /transl_table=11
                     /translation="MAQKERTAAVPAAVTWGLLGAWAVHDAEELVTMARWLRAARPRLE
                     QRFPAVPWARLELSQAHVTVAIGLMGGVMAGAAALGARTGGRSPVFQAVLAGFGAHGAG
                     HLAQAAVVRGYTPGALTSPVVVIPFTVWAWRRLKAAGVPTGGGGRSAAAGLAALPLVLG
                     AVHGLAHVLTRRASASRAGRTREGGRAVSRGRRS"
     misc_feature    complement(19575..19589)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    20030..20044
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
ORIGIN
        1 ggatgaccgg cgcgcagcag gccgcgcacc gcgtgcctga gcacctgctc cacgtgcgag
       61 ccgccgtcgg agcgccagcg cgccagcagg ccgagcgcca cctccggatg gtccttggcc
      121 aggtcgttga cgtggttggc gaccgagcgg cggacgtact cgctggggtc gtcgcgcagc
      181 cggtcgagca cgggaagcgt ggggcccggg gtcatcagcc agggcacgcg ggcggcccag
      241 ggcaggcgcg ggcggctgcc ctcggacgcc agccgccgca ggtgctcgtc gggggactcc
      301 gcccacccga gcatgatctt cagggcgtcg tcgcggtgac gttcgaggaa gggacggacg
      361 gcgaactcgc ccgtcgcgta cggcgtgagc gcggccagcg tcgccatcgc ctcctccagg
      421 tgaccgagcc cgtgcgccgc cgtgtggtcg gtggcgggcc agccgctcca caggtcgagc
      481 gccccctgag aggcgcacgc ccgcacgacg gcggcggcct ccgggtacgg cagcggcagc
      541 gcctcgtgca gcgcgccggc cacgtgcctg acccggtctt tcagctccag cccgccgagc
      601 ccgtcgaggg cgcgggcgac gaaccggccg cgagggaagg gcggccacgc ggcggccagc
      661 ccgtcggcca gcgcggacac ggactggagg ttgatgcggt ccttcagagg ttgcgccacg
      721 cggacaccct gccagacggc accgacagat ccgggacgcg gcgggggacg gggcgagggg
      781 gtcaggcgat ggtgatgagg cggatgaggt cttcgcggaa gcggtcgtag tcctcgacgg
      841 cgccgaggag gtcgccggag tcgcgttcct tctcgcgggc cagggccagg acggcggtgc
      901 ccgcgtcggt gagctcgacc agcatgcggc ggcggtcgcg ggcgtcggag cgcttggcga
      961 tgtagccggt gcggcgcagg tgctcgatgg tgcggctcat cgtctggtcg gtgacccggc
     1021 aggcggtcgc cagctcccgc tgcggcagcg ggcccgaggt gaggtggtgc agggcgatca
     1081 gcccggcgtg gctgaggtgg tgggcggcga ggaagtcgtg gaagcgccgc tcgaccaggc
     1141 gggcggccac cgacagcagg cggcccacgg gccaggagcc gatgtcggcg cgcacgtcgt
     1201 cggcggcgtc ggcgacgtac cgcgcgtcgt cggccgcgta ggaggcggcg tcgtcggccg
     1261 tgcgggaggc ggcggcgtcg gcctcgtggg aagcggcgtc gtcggccgtg cgggaggcgg
     1321 cggcgtcggc ctcgtgaggt gtggtgccgg gccgccggga gggggtggtc gcctgtcgtt
     1381 cctccgccac ccgctcattc ttccagacgc gcgggctccc gcggtcgcgc gaggcgggcg
     1441 gcccgcaggc cgagccacag cagcagggcc agcaccccga ccagggcgta ctcgatggcc
     1501 gggatgcgca ccacggccga cacgccggcg aggtcgccgc gcaggccgta cacggcgagg
     1561 gcgccggccg cgtacgccag cccgagcgcc caccgcaccc cccgtccgag cccgagcccg
     1621 tgcatctggg tgacgacgaa caccccgagg aagccgaaca ggaacatcgg ccacatcccg
     1681 tcggggccgc tgttcatgac ggccacgagc gtgccgtgcg ccgccacggc cagctccagc
     1741 gtgacggtcc accagcggtt ggtgtgggcc ctggtcagga agaggctgcc ctggaggagc
     1801 agcaggaaca tgtacaggaa cccgatcagg tggccgctgg tgttctccat cgggtggtac
     1861 cagaacgtgt agaccgccgc ccacgagaag aggtagccgt ggtagcggcg ggcgaaggcg
     1921 acgagctcct gccggatcgg cgcgggccgg ccgaggaaca ggccgcgccg ccggttctcc
     1981 atgagcagca cggccaccag cagcaggatc accgagccct gggagctgaa gatggacacg
     2041 tcctgcgcga ggccgtcgta gaagagctgg gtctgcacct cgtgcagggc gatgaagccg
     2101 gtgttgacgg cgagcgcggc cacgttgagc cggtgcaggc cggaggtgta gcggcggacg
     2161 cgggtccggg cgcggtggat gagccaccag aagatcacct ggtgggcggc gtagcaggcc
     2221 caggccgagg cccgggtcca gaaggtcggc tcgggcagct tccagtagta ccaggacgcg
     2281 ccctggtcgg gcagcagctc gatgccgctc agccgccggc cgagcagcca gaccaggccg
     2341 gtgagcacga cgctcgcggc cacgccggcg gccagcacgc gaccggcccg cacatccttc
     2401 agcatgctga acattatgcg aagtgttcag cgtgctgaac aacctcagga ggtggactcc
     2461 cgccaccggt tcgtgatcgg caggcggcgg tccctgccga agttcttcgg cgtgatcttc
     2521 ggccccggcg ggtactgccg ccgcttgtac tcggccaggt ccaccagccg gatcacccgc
     2581 gtcaccagct cggggtcgtg cccggcggcg atgagctcct gcgagcccat gtccttctcc
     2641 acgtagtcgt ccagcagccg gtccagcacc tcgtacggcg gcagcgagtc ggtgtcgcgc
     2701 tggtccggcc gcagctcggc gctcggctcc ttggagatcg agttctccgg gatcggccgc
     2761 tcggcctcca gcaggaaccc ggcgcaggtg tgggcgttgc gccagcgggc cagctcccac
     2821 accatcgtct tcggcacgtc cttgatcggg gcgaagccgc ccgccgagtc gccgtagagc
     2881 gtggagtagc cggtcgccag ctcgctcttg ttgccggtgg tgagcaccag gtggccgttc
     2941 tggttggaca gccccatgag gatcgtgccg cgcacccggg cctggaggtt ctcggcggcc
     3001 aggcccgaca gctcgatctc cttctcgaac gcggtgacga tgtcggcgat cggcgcgacc
     3061 tgcgagcgca cgccctgccg ccgcaccagc tcctcggcgt cggtcagcga gtgctcggag
     3121 gagtagcgcg agggcatgag caccacgttg acccggtcgg gaccgaccgc gtcggcggcg
     3181 atcgtcgcgg tcagcgccga gtcgatgccg ccggacaggc ccaggatgac cgagcggaag
     3241 ccgttcttgg cgacgtagtc gcgcaccgcg agcaccagcg ccgagtagac ctcggcgtgc
     3301 aggtcgagcc gctcggcgac gggcgcgggc tcggcggggt agggcgcgac gggctcgccg
     3361 gacagcacca ggcggtcgac ggtgatcgtc gtgccgtcgc ccgcgtcgta cgggaacgcg
     3421 cccggcgccg cctcggagac cggcaggccg gtcaggtcca ccaccagcag ctcctcgcgg
     3481 aactgcccgg cccgcgcgac cagctctccg gcgccgtcca ccacgatcga gtcgccgtcg
     3541 aagaccagct cgtcctgccc gccgacctgg ttcacgtaga ccagcgcgca gccggcctcg
     3601 cgggcccgcc gggcgcacag ctccaggcgg acgtcgtcct tctccttctc gtacggcgag
     3661 gcgttcggca ccaccagcag cccggccccc gcctgcccga cgacggacac cggcccgccc
     3721 tcctgccaga ggtcctcgca gacggcgacg gccacgtcca cgccgtgcag ccggaagatc
     3781 ggcagccggt cgccgcgcac gaagtagcgg tactcgtcga acacgccgta gttcggcagg
     3841 tggtgcttgg ccgtcctggc caccacctcg ccctggtaca ggagcgcggc ggcgtccagc
     3901 ggggcgccct tcggctggcc cacgcgcggc gcgaggcccg cgcggtccac gtagccggcc
     3961 accacgggca gctcgccgag gccctcctcc gccagcctgc gcgccacctg ctccagggtc
     4021 ctgatgccgg cgtccacgaa ggacgtgcgc agcacgaggt cctccaccgg gtagccggtg
     4081 aggaacatct cggtgaagac gacgaggtga gcgccgcgtt cggcggcgtc gcgggtccac
     4141 gcgaccagcc ggtccgcgtt ggcgctcagg tcgcctacgg tcgggttcgt ctgtgccagg
     4201 gcgatgcgca gttgtgccac gcgaccagcc tagtacgccc cgatttttat cgtcaaagcg
     4261 acgaaaagtg cgctttctcg ccaggtgtca ccaaaccgga ctcgtacgcc gccatcacga
     4321 gctgcgcccg gtcgaacagc cccaggtgct ccagcagcgc cttcaccagc aaccccactt
     4381 cctcctccgg caacgacaac gtctggccga tctgccggtt cgtcagcccg cgcgcgacga
     4441 gcttcagcac gtccagcagg gcgtcggaga gcccggccag cgccggggga gaggccgggt
     4501 cggtgcgccc ggcgaacgcc gagatcagcc gggtcgtcat cgccgggtcg atgagcgcgt
     4561 ccccggcagc cgccgccctg atcgccgcca ggaactgctc gggggccgcc gtcttcagca
     4621 ggaagccgct caccccggcg cggagcgccg cgtacaggtt ctcgtcgctg ccgaacgtgg
     4681 tcatcatcac cacgcgcggc gggcgctcct cggccaggat ccggcgggcg gcggccaggc
     4741 cgtccaggcg cggcatctgg atgtcgagca gcaccacgtc ggggcggacg gcggggacgg
     4801 ccgcgatggc ctcctcgccg ttggtcgcct cgccggccca ggtcacgccg gggtcgctgt
     4861 ccagcatggc cttcaccccg gcccgcacca gcgcctggtc gtcggcgacg agcacgcgca
     4921 gcacgccgcc gggcgaagcg ggcgcggacg gggcggcggg ctgggcggcg gattgggcgg
     4981 cggggacgac ggcggggacg acggcggggg cctcgggggc gggcggctcc tccagccgct
     5041 gcgccagcat gtcggcctcc agccgcttca gcccggccgt caggtccagc cccagctcgt
     5101 cccgccacac cgcgcgggcc cggcgcagcg cggcgagcgc gtcgccctgg cggcccatcc
     5161 ggtacagggc cacggccagc agccgccacg cctcctcgcg cagcgggtgc tcggcggcgt
     5221 gcgcctccag gtcggccacc agggacgtgg cccgccccag cgtcagcccg gcgtccgcgc
     5281 gccgctcgac cgcgatcagg cgcagctcct ccagccggcc cgcctcggtg accgcccagc
     5341 tcaggtcggc gaactcggcc agcgccggcc cgcgccacag cccgagcgcg gcctccatgt
     5401 cggcccacac ctgcccgggc gggccgtcgg acttgaccag gccctcgaac cgccaggcgt
     5461 ccacctgccc ggtctcggcc cgcagcgcgt agccgggcgg cgcggtgacc agcacctccg
     5521 cctcctcgcg cggggcgcgg ccgggctcca gggcgcgccg caggcgggag acgtagccct
     5581 ggatggtgga cagggcctgc gcgggcgggt cgcccggcca caactcgtcg atgagggtgt
     5641 tcacgggcac ggcgcggccg ccggccacga gcaggcgcgc gagcaccgcc cgctgccgct
     5701 ggccgccgag gtcgagaggg gcaccgtccg cccaggcttg gaacggtccc agcgcggtga
     5761 aagtcagcat gtcaggcgta actgtagagc gagaacgtgt tctggcatat ggcgaattgt
     5821 cacagtggga gctcggcctg gacaacggtg cctcctcctt cggcgtcccg gacggcgcag
     5881 gtgccgccca gctcggcggt ccgctcgcgc atcgagtgca gccccacgcc ggggcgcgcg
     5941 tccggcgaca gccccacccc gtcgtcggtc acggtcaccc gcagcagcgc gccctcccgg
     6001 cgcagcgcca cggccacgcg ggtggcccgc gcgtgcttgc gcgcgttggt cagggcctcc
     6061 tggacgatcc ggtacgcggc cacctcggcg gcagccggca gcccggccag ctctcccgac
     6121 acctcgaccg gcgtccccgc cagctcctcg accgccccgg ccaggcccag ctcgtccagg
     6181 gcgggcgggc gcagcccgta gacgagctcc ctgatgtcgg cgcgcaccgc ctccatgccg
     6241 gcgttcagcc cggcgagcag gcgctcggcg tcgccgggcg aggtgcgggc ggtgcggcgg
     6301 gcggcgttga tcgacatggc catgccggtc agcgactggc cgagcccgtc gtgcaggtcg
     6361 cggcgcagcc ggcggcgctc ctcctcgcgg gcggtcagga tgcgctcgcg cgagcgccgc
     6421 agcgcggccg tcatccgcac cgcgtgcgcg gcgtcggcca cgtacgggac cagcgtcgcg
     6481 accacccgct cgtcgtgcgc ggccgggaac ctgcggcggc caggcggccc gatcagcagc
     6541 cgcccgaccg gctcgccgtg ccacaccagc ggcaccgtcc gcgcgggcgc ggcccccatc
     6601 gtgcccgagg cggtgacgtc gccgtccacc tcgacggccg cgccggtggc cgacaggccc
     6661 tcgcgcagca cgtccagggt ggccagcagg ccgtgcaggg ggtcggcgtg ctggagccgg
     6721 tgccgcagcc gggcggccag cgcctcgggg acgccggtgc tgccgtacag gagccggtcc
     6781 acgccgcgtt gcaggccgcg ccgcatgggg tggaagaacg cgcccgcgaa gatcgctgcg
     6841 gcgatgccgg cgaccgggtc cacctccgac aggaacagcc cggccgcggc gccggcggcc
     6901 acgtacacgc cggtgatcac gatcgccagc ccggtgccca ccagcgcccg gctgatcagc
     6961 gtgtcgatgc cgaacagccg gtagcgcagc accgccaccg cgatcgccgc cgggatcagc
     7021 gggatcgcca gggacgccgt ccacgccgcc gcgccgcccg cgatccacgg caccagcagg
     7081 ccgggcagcg cgaccagcag ccacaggagc tggcgccgct cgaccgcgcc gccccgggcg
     7141 aagcgcacca ccagcgaggc gaacgccagc gccatcgcgg ccccggccgt ccagcgcgcg
     7201 gccggggcga ggccggccca ctccagggcc gccccggcga gggccagcca caccaccgga
     7261 cgccagcgcc gcgacggcag cgcgccggcc gggtagagca gcggcagcag cacgccgagg
     7321 gtcagctcca gcacctggcg ggacagcgtg accagccagg ggaggccggc gcccgacagc
     7381 tcgccgaggt tggcggccag gacgccgatc gcggcgctca gcccgccggc gcacagcagc
     7441 cacccgatga ccaggcgcgg cctgctgtgg acgaggatcg cgccgaagac cgggaaggcg
     7501 gtgccggcca cgtcctcggg agcgaacggc agcggggtga gcggcgacgg cgggagctgc
     7561 gcggtgaccc agatgtcggc cagctccagg gtgacggcga gcgtggcgat cgcgatcgcc
     7621 gtccctcgcg cgagactcgc gcggcgcatc tcaccgccct ttccaccctt tcgtcgtgtg
     7681 gtggaaatta tcggcggcct gccaacaacc gatcaaaatt ttctcaacga gggctcgcgg
     7741 ccctcaggcg cgccgccgga tcgccgggcc gagggccacc atgccggccg ccgacaccac
     7801 cccgatagcg ccgatcgtcc accacagcac ccgcggcccc agctccagca gcggcccgcc
     7861 gagcagcggc gccagcgcgg ccgccgccga ccaggccagc ccgaacaggc ccgcgtaccg
     7921 cccccgcagg tgcgcgggcg cgagcgcggc cacgatgccg cccgcgatgc cggccgtgac
     7981 gatctcgccc gccgtccaca ccgcgaccgt gacggccagg ccgagcgtgc tggtgacgta
     8041 cccggtcagc gcgaaccccg cccccatcac cgcgaggccc agcgcgaacg tgcgggacgg
     8101 gtcccgccgc ccgagccagc ccgacaccag cggctgcacg accacgatca gcaccccgtt
     8161 cagcgccatg gccagtccgt actgggcggc gctgagcccc gccaccttgg tcatggccac
     8221 cggcagcatg gtcatcgtct gcgcgtacac cagcgcgttg cccagcacga ccagcgtgaa
     8281 cgccaccatc acccggtctc gcagcaccgc gccgaacccg cccgcggact cccgcgcccc
     8341 ctcgggccgc gtctcgggga ccgcccgcca caccagcacc gcgaagacca cgctggagac
     8401 cgcgtcgatc cagaacagcc agaggaaccc catccccgcc agccagccgc ccgccgtcat
     8461 gccgaccgag tagccgaggt tgatccccca gaacagcagc ccgtacgcgc gcggccgctc
     8521 cccgggtggc accaggtcgg ccaccatcgc gctggaggcc ggccggtaga ggtccatcac
     8581 cacgccgagc accagcatgg aggcgaggat ggccggcagc gtggcgctgt agccgagcgc
     8641 gagcagcgcg gcggccgtgg ccagcatgcc gcccgacagc gtggcccgcc gtccgatgcg
     8701 gtcggccagc gtgccggcga gcggctgcga cagcagcgac cccgcgccga agacgcccat
     8761 caccaggccc gccgcggcca ccgacaggcc gcggctctgg gtgaggtaga cgccggtgaa
     8821 gggcatcacc atggtgccca ggcggttgac cacggtgccg ccccacaggg cccagaaggg
     8881 gcggggcagc ccggcgacct gcgcccgcag gaacgacggc ggcttctcga cagtagggct
     8941 cgacacgtct cgaagagtgc tcccgccggc ttggccgggc gaacgattta gcccacacta
     9001 aaaggatgtc catcacctgg gtgctgcggc cggacgacgt ggcccgcatc cgcttcgcct
     9061 tctccccgat gtgggagctc gtggccagcc tccgcaccct gcgccggccc gcccgccagt
     9121 cgctgcacct gccctggatc aaggccgtgc gcccccggct cgccgggctc gacctggccg
     9181 agctgatggc gctcgtgccc gccatcggct acctggccga cttcctcacc ccgccgcccg
     9241 acacgccgct gcccgacttc gccgccgagc tggagcgggt caggcgcacc ccgccggaac
     9301 gggcccgcga ggaggccctg cgggtcaccg gcaccgaccc ggccctgctc cggcgcttcg
     9361 ccgccgaccc ggccgcgggc gtgaccaggg tcgccgacgc gctggaggcg tactgggaca
     9421 ggtgcttcgc cgagttctgg ccacgcgtgt acgcgctgct ggagcgcgac gtgctgcgcc
     9481 gctcccggca gctcgcccag ggcggcgcga gcgagctgtt cgccgcgctc gacccggccg
     9541 tgacctggac gggggagcgg ctggtcgtcg accggccctg gtgcgcgcag gaagggctgc
     9601 acggcgacgg gctggtgctg gtgcccaccg cgttccactg gccgtcggtg gccgtgatga
     9661 gcgcgccgta ccagtcgatg ctggtctatc ccgtgctggg cgtcggcacc ctgtgggagg
     9721 agggcccgcc gcccgcgccc ggcgccctcg ccgcgctcct cggccgcagc cgggcgcgga
     9781 tcctgctcgc gctggccgag cccgtcacca cctcggcgct ggccgcccgc atgtcgctga
     9841 cgcctggcgc ggtcagccag cacctcggcg tgctcagcga cggcgggctc gcggtgggca
     9901 tgcgggtcgg caagcaggtc ctctaccggc gcaccctggc cggcgacatg ctcgccggcc
     9961 aggggtgacc gcacccgggc gcgcggcccc cccaccgggc tcaggcgtag cgcgccgact
    10021 ccagcagcca gtcgaggtgg gcgcgcggcg ccgccaggta ggcgcaggcc accttgctga
    10081 cgtcgcgcgc cgccttgggc gcgaggtcgt gcagcggcag ccgccgggcc gccttgtgca
    10141 tgtcctcgca gcggcgcgcg atccggtcca gcacccaggc cgtcgcctcc cgctcgccga
    10201 gcccgagctg gcgcatcgcc agcaccacga agttgtgcac gtcgccgcgc tccttgggcc
    10261 gcgaggcgac gtcgttgcac caggcggtga cgtcgctgca ggcgtccacg agctgctgcc
    10321 acggctccga ggcgtgcatc caggccggca cctccacccg caggcacggc tccaccaggt
    10381 cgtacaggta cggcccgacc gtgcccctgc gcagcgccgg gtactcctcc agcgtcggca
    10441 tccggcccgc cgcccggttg tcggcctcgg tgcggcaggc gtcgtgctgg cgttgcagcc
    10501 ccaccgcgaa cctggcccgc caccggtcgc tcatccgcgc gctcgtcacc cgccacaggt
    10561 cggcgaaggc cgcctccagc gggtgccgcg ccccgccctg gagcaggccc tggaagacct
    10621 ccaggcggca ctcgccctcg tccagctcgt cgtccaggtg gaacagccag gtcagccact
    10681 gcgcgaacag cgccgccgcg gccgcgtcga actcggcgaa ggcccggccg gccatccggt
    10741 ggaagccgac gccggggtcg gcccgcaggc cggtgcgcct ggcccagtcg atgacggcgg
    10801 cctcgatggc gtacacggcc gggtgcatgc ggcacggctc ggccatggcc ggcacccgct
    10861 cggtcagcgg catgagcgcc agcgccgccg agccgccgcg ccgcggcagc ggcatcatcg
    10921 acgacaggac cgaacgcagc gcggtgcgca ccgtggcgaa catcgtcgcg gtcacggtgg
    10981 agtgcccgtc ggcggcgccg ccgggctcgt cagtggtgtt cacggtcgtg tccacagcgg
    11041 cgctcacagc gggccgaaca gccagttgcc cggggcgttc gggtcggcgc tgcggtagaa
    11101 gtcggcggcg gcggcgacca ggccggccac ggtcagcctg ccccgtcccg cccggtccag
    11161 ccggtcgaag gcctcgtcca cgtcgtcgta ggcgacgccg aacgcgctca gcatggtgcg
    11221 gaactcgccc ggggagatct cgccgtcccg gtcgccgtcg cacagctccg ccaccgcgac
    11281 cgtcgccggg cggaagaccg ggtcgtagtg accgcccgtg acgaacgccg ccgtcatggc
    11341 ggtgcggaag tccgggcggg cgatgccgga gtcgccgtcg cgttccagcg tccgcgccag
    11401 cgtggcccag atgccgtcga agctctcgac gaggctcgcc ccggtgaccg aggtggggga
    11461 ctccccgaag cccaccagga tgcgcgcccc caggccgagc aggtccgcac gctcgacgac
    11521 cccgttgccg ttggcgtcga tgtggtcgaa ggcccgatcg agcttgtgat tgagcaggtc
    11581 gatagccacc ttgcctcccc cgagactgac tgcgttgatc acagtaagac ggggcggggg
    11641 ctttgtcagc gaggctcgca ccggctagtt cgcccgccct cgcgcggcgt cctcaccgac
    11701 accccccgta acctgtgcga aacacggaca cggcatgctg gtaagagacc tgttctgtca
    11761 tcaagagggg atgccttgga ccgccagcag gagttcgtgc tccgcacgct cgaggaacgc
    11821 gacatccggt tcatccggct ctggttcacc gacgttctcg gcttcctcaa gtccgtcgcc
    11881 atcgccccgg ccgagctgga gggcgccttc gccgagggca tcgggttcga cggctcggcc
    11941 atcgagggct tcgcccgcgt ctacgagtcc gacatgctcg ccaagcccga cccggcgacg
    12001 ttccagatcc tgccgtggcg cagcgagacg ccgggcgccg gccgcatctt ctgcgacatc
    12061 ctgatgcccg acggctcgcc gtcgcacgcc gacccgcgct gggtgctcaa gcgcacgctc
    12121 gccaagtgcg ccgacatggg cttcaccttc tacacccacc cggagatcga gttcttcctg
    12181 ctgaagaacc ggcccgagcc cggccagcgg cccgagccga tcgactccgg cggctacttc
    12241 gaccacacgc cgcacagctc cggccacgac ttccggcgcc aggcgatcat gatgctggag
    12301 tcgatgggca tctcggtgga gttcagccac cacgagggcg cgcccggcca gcaggagatc
    12361 gacctgcgct acgccgacgc gctcaccacc gccgacaaca tcatgacctt ccgcctggtc
    12421 atgaaggagg tcgcgctgga gcagggcatc tgggcctcgt tcatgcccaa gccgttcacc
    12481 gagcacccgg gctccggcat gcacacccac atgtcgctgt tcgagggcga ccgcaacgcc
    12541 ttctacgagg ccggctccga ctaccgcctg tccaaggtcg gccggtcgtt catcgccggg
    12601 ctgctgcggc acgccgccga gatcaccgcc atcaccaacc agtgggtcaa ctcctacaag
    12661 cggctgtggg gcggcgccga ggccatcgcg ggccagggcg gcgaggcccc ctcgtacgtg
    12721 tgctggggcc acaacaaccg ctcggccctg gtccgggtgc cgatgtacaa gccgcacaag
    12781 ggcggctcga cccgcatcga gttccgctcg ctcgactccg cctgcaaccc ctacctggcc
    12841 ttcgcgctca tcctggcggc cgggctcaag ggcatcgagg agggctacga gctgccgccg
    12901 gcggccgagg acaacgtctg gacgctcacc agcgccgagc gccgcgccct cggcatcgag
    12961 ccgctgccgg gctcgctcaa cgacgccatc gaggtgatgg agcgcagcga gctggtcgcc
    13021 gagacgctcg gcgagcacgt cttcgacttc ttcctgcgca acaagcggtc ggagtggcgc
    13081 gagtaccgcc gccacgtcac cgagttcgag ctgggccgtt acctgcccat cctctgacgc
    13141 cagcatgcgg gaagcccggc gcggagcggt ccgcgccggg ctttctcacg tctcggggcc
    13201 tacttgttga cgtgccggta caggtacacc gccgccttct tcatggcggc gccgctcttg
    13261 cccgcgcggt gccgctcggc ggcggccacg gaggtcttga acgtggtcgc gccgtgcacc
    13321 ttggccgagg agttgtacac gccgtgcgcg tagttcagcc acgaggccag cagctcgcgg
    13381 tcgagcagcg ccttggcggc cttgctccgg gtggcgagca ccttgtacgc cttggtcagc
    13441 gtgcccgcgt ccgtcagctc ggggaagacc ttgctgccgt tctgcgccag cgtgaggtag
    13501 cagcgcagcg tgtcgtcgct gagcgagccc ttgccgcgca gcatctccct ggcccacgct
    13561 ttggcgctca gcggcttggt gcccttgccg cgggagcagg tgtcggggac gggctgcggg
    13621 tcgccgtaga tgccggggtc gacgttcgtg ctgtggtcgt cgggggagga cgtcggggtc
    13681 ggcgaggggc tgtgcgagcc ggtcgggcgc ggggtggcgg tcgtggtcgg cgtcgcggtg
    13741 ggggtcgccg tcggggtggc ggtcggcgtg ggcgtcgggg tggccttggg cggcagggcc
    13801 gcggtcaggt cgatccgctt ggtggtgacg ccgccgtagg tgatggcctt gccggtgtcc
    13861 tgcagcttgg cgacccggcc cgcgtcgctg agctgcgggt acgcctgccg gatcagcgcc
    13921 agcgcgccgg ccacgtgggg ggcggccatc gaggtgccgt tgagcacgcc gtagccgccg
    13981 ccgggcaccg agctgttgat ctgcacgccc ggggcgaaca ggtcgagcag ccggccgcgg
    14041 ttgctgaagc tcgccacggc gtcgttgtcg tcggtggcgc ccaccgtcac cgcggcggag
    14101 acgcaggccg ggctggagac gccgtcggtg aagccgttgt tgcccgcggc gacgacgacg
    14161 ctcacgccga actgcttgag ccagacgatc tcctccttga gcgcgcccgc cgacgggtcg
    14221 tcgtcgcagg gctgcgtctg cttggggccg ccgccgaggc tcatgttggc ggcgatgacg
    14281 ttctgaccgg cgtgcacgct gtccacgtac tgcagcgcgg ccttctgagc ggagacgaag
    14341 gtcgcgaagc acggcgcggc cacccccagc tcctcctggc agacggcgcc gttcagccgg
    14401 gtgaacacct ggatcggcag gatgccggcc tccggggcca cgccgttgga cggggcgccg
    14461 gccgccttct tgccggccgc gatgcccgcg acgtgggtgc cgtggtagca ctggttcttg
    14521 ccgttcacga cgcacgcggc ggtctcggcg tcggcggcgc cggcgccgac ctgcaccgac
    14581 tggccgttcg ggcacagcgg cacggccccg tagtacgggt cggtcgaggt ggccgagaag
    14641 cacgcctcgg cgacgatgcg gccggcgaag aacgggtggt cgcggtcgat gccggtgtcg
    14701 aggacggcga tggtggagcc cttgccggtc cagcccgcct cgttggcctt gtccgagccg
    14761 atcagcttgg tgctgacgtc gaggctcggg aggctcagcc ggtcctcgta gacggccgcg
    14821 acgcggtcgt cggtcctgac ctcctccagc gtcgccttgt cgagggtggc gacgaggaag
    14881 tcgtcggaga gcttcttgtc gacgacctgg acgcccttgg aggcgtcctc ggtgtccttg
    14941 gccacggcgc cgacgctctg gcccttcttc agctcgatga tggcgcggac cttgtgcccg
    15001 ctgcgcacct cggccgtgac gctcttggcg acctcggggt cgccggccgc ggcctgggcg
    15061 ggcgcggcgg ccgcgagcgc ggccgtggtg gtgacggcga gcacggacgc gcccgccagc
    15121 agagaccgta gtctcactgg acctccgggg ggtagagggg gtccacgcgc cggtcgtgcg
    15181 tgcgggggtg cgagcagcgc tcagcgaacc ccgcgtctcc ccgtggccga cgttggaacg
    15241 tttccccgtt gacgtatgag gcgcaagcgt acggagtgac aggacaaaac ggtgggaatg
    15301 acgttattcc gttatgggga aaccaccgct taccggatct tggtcggcct cgaacaggat
    15361 ggcctccagc agggcggccg tgccgcggtc caccacccgg gcggcggcgg ccggcgccgg
    15421 gtcgccgttc ctgacccgcg ccatcagctc ctcccaccgc cgccggtgcc gggcgaacgt
    15481 gcgcgccgcc accacccggc cccgctcgcg ctggcccgcc agcgccgcct ccggcgtggt
    15541 gtccagcagg agcaggtgca gccgcgcgcc gtgccggcgg gccagccagt cgaggccgcg
    15601 cagcaccgac ggcgcgcagc cgcggttgtg cgcgacgacc gaccggccgt ccgccagcgc
    15661 ccggctgatg cggctcaggt gggtggcgaa gaccaccgcc cgccgcaccg ggtgcggggc
    15721 ccaggccagc cggcccgccc agtgccgctt ggcctggtag gtgtcgatca ccgtgaccgc
    15781 ctccctggcc acggggaggc tctccgcgcc gtccagcgcg tacagccggc gcagcagcgt
    15841 cgtcttgccc gcccccggca gcccggtcag gatgaccagg gacccgggcg ggtaacgcac
    15901 cgtgccggtc cgcgcgccct cgtcgagcac gtccaagcga tcttcctccc ccgtgtacgg
    15961 cgactgtcgg cctcgcgccc ctccagcctc gccgagcggg ccgcccggcg cgcgcctcct
    16021 gtccggcgaa tccgaaggtc gctcgtatca gccgaatggt gtgcgggacg ccggaaaccc
    16081 ccgctaaagt actgccggac ggcttgatcg gcctcactcc gggagcgctc ctggagtgag
    16141 gccgattttc gttgcttctg acccccgagt cacttccgcg gcatgtgcgg tgcctagcgt
    16201 gctgaccggg ggtggggaag tttcggaccc cttcggggcg ttacgtggtg gtgcggaccg
    16261 gatgttagga ccccccgacc tctgggtaaa gcgggtgtcc agtaaaatcg gtctgttctt
    16321 tatggtattt caggacttcg cgccccttgt ggcgatatgg gagggtgtgg catgacgacg
    16381 gctgccctgc agaccgtgtt gaccgttccc cggcgtttcc gcgggccaga gggagtcgcc
    16441 aacggcggct ggatcgcggg caccatggcg gagacgctca acggggggcg atcagccgtc
    16501 gaggtcacgc tccacgcccc cacgccgctg gagaccgagc tgcgccttga gcacatggcc
    16561 aactccgcgt ccctctcgca cggcgaccgg ctgctcgtcg aggccatccc ggtcgccgag
    16621 gacctggagg ggcccgggtt cgtgccgttc aacgacgccg cccgcgccga ggccgggttt
    16681 gccgggctga aggcgcaccc gttcgccgag tgcttcgcct gcggcctgcg cgagccgggc
    16741 gacggcctgc gcatcttccc cggcccggtg gccggcaccg acctggtggc ggccggctgg
    16801 cgggtgccgt tcacggtggc cggcgaggac ggcgtgccgg cctcgatcat cggcgcggtg
    16861 ctcgactgca tcaccggctg ggcgcacttc ggccccggcg agagcgcgct gctcggccgc
    16921 ctggccgtgc agatccaccg cgacgtgcac cccggcggcc gctactccgt ggtggccagg
    16981 ccgaccggcc gcgacggccg caagatgttc ggccagagcg ccatctacga ggtggacggc
    17041 acgctggtcg ccgccggccg ggccacctgg atcgctccac gctgaccccg caccgggtca
    17101 ccgagcagcc gcccatcccg ccacgaacgg ggtgggcggc gtcgtctcag gaggtgagcc
    17161 ggtccaccac ggtggccacc ggccgctcgc cgaacaggat cgtgtagtgg ttgcagtccg
    17221 gcacgacctc gtcgcgcagg ccgggcagcc gggcggtcca cggcgccacc aggtcgtcgg
    17281 ggagcatgcc ggtgtcctgg tccagcagcc cgcgcggcgc ccgcagcagc cgcagcggcg
    17341 acttgacggc ctccagcgcc gccgcggcct cggcctgcgc ggtgtgcagc cagcggccgt
    17401 cctccagcac ggccgcggcc accgcccgcg agcgcagcgc gccgtccggg ccggtcaggt
    17461 cgtagcgcac gtaccgctcg acgtcgtcgc tccagcggcc cctgaaggcc gggtgggcgc
    17521 ggaagaagtc cacgtacgcc tccgccgacg ggtacgtccg ccgcagccgg tccagcgccg
    17581 ggccgagggc cgcggccagc gcctcgtccg ggtccacgcc ctcgggcagc ggcgggaacg
    17641 ggatgccgcc gtccaccagc accacgcggg cgaagtcgcg ccgggcggcg gccagggcgg
    17701 ccacgtacgc gcccatggag tggccggtca gcacggtgtc gccggtcgcg ccgacgtgct
    17761 cggccacgcg gaggacgtcc tcggcgtggc ggggcagacc gtacgggccg ggcagcccgg
    17821 cgctgtggcc ccggccgcgc aggtccatgg cgaccagcgt ccagccggcg ggcagccggc
    17881 gggccaccgc gccccaggcc atgagggagg cggtgatgcc gtggacggcg atgatcagac
    17941 gggggccggt cccggcgcgg gcgacgcgca gcccgttcac gtcctcgaag tggaagctca
    18001 tgacgggatc ctaggaactc gcgccccggc tgtcgccgtc cccacgccct caagtgattt
    18061 gccccgataa ttacctgtat gcggatcact gtcatcgagc acgaggccga ggccggcctc
    18121 ggctacctcg ccggctggct cggcctcgcc tgcgacgtcg tgcggccgta cctgggggag
    18181 gaggtcccgg cgcgggccgc ggacgcgctc atcgtgctcg gcggcgcggc ggcggcctgg
    18241 gaggacgagc gcagcccgtg gcagcccgcc acccgcgacc tgctgcggcg ggccgtggac
    18301 gaggccacgc ccacgctcgg catctgcctg ggcgcgcagc tgctcaccct ggcctgcggc
    18361 ggcgtggtcg agcgcggcgc gaacggcctg gagatcggcg cccgcgcggt gaccgccctg
    18421 cccgccgccc gcgaggaccg gctgctggcc ggcgtcgaga cggccgtggc cgtgcagtac
    18481 caccaggacg cgataaccgt cctgccggac ggcgcggtgc cgctcatgac cggcggccag
    18541 tacccgaacc aggcctaccg gctgggagag gcggcctggg ccgtgcagtt ccatcccgag
    18601 gccacgccgg agatcttcgc gtcctggacg cacggctcgg acctggacgc ggccgaggac
    18661 ctgaaccgcg aggtgaaggc ggccgagccg gctctcgtgg cgacctggcg cccggtcgcg
    18721 cgcgccttcg ccgacgtcat caggaccgcc gcccgcggct gaccgcccgc ccgccctcgc
    18781 gggtccgtcc cgcgcgggac gcggacgcgc gccgggtgag gacgtgcgcc agcccgtgca
    18841 ccgcgcccag gaccagcggc agcgccgcga gcccggccgc cgccgaccgc ccgcccccgc
    18901 cggtcggcac gccggccgcc ttgagccgcc gccacgccca caccgtgaac gggatcacca
    18961 ccaccggcga ggtgagcgcc cccggcgtgt agccgcgcac caccgcggcc tgcgccaggt
    19021 gcccggcgcc gtgcgccccg aacccggcca gcaccgcctg gaagaccggg ctccgcccgc
    19081 cggtgcgcgc cccgagcgcg gccgcccccg ccatgacgcc gcccatcagc ccgatggcca
    19141 cggtgacgtg cgcctgcgac agctccagcc gcgcccacgg caccgcgggg aagcgctgct
    19201 ccagccgcgg ccgggcggcc cgcagccacc gcgccatcgt caccagctcc tcggcgtcgt
    19261 gcacggccca cgcgccgagc agcccccacg tcacggccgc gggaaccgcg gccgtccgct
    19321 ccttctgagc catctccgcc tccctatcac aacgcaacgt tgcgttgcat tctacgaccg
    19381 ccggccccgg tcctgtcaag atggaggggt gcccaggatc gaatccaccg ccgcgcgcct
    19441 cgccaagctc ggtttcgccg acggagcccg ggccgcccag ctcgtccgcc aggcgggccc
    19501 cggcctcgac gacctgctga cgtcgctggt cgacgtcgcc gaccccgacc tggccctggt
    19561 ctcgctcacc cggctggccg agcgcgaccc ggccgtcctc ggcgccctgc gcgacgacga
    19621 gagcctgcgc gcgcggctgc tggccgtgct cggcgtcagc gacgccctcg gcgagcacct
    19681 ggtccgccac cccggcgacg tcgcccgcct ggcccggccg cgccaggacg aggccagggc
    19741 cgagctgctg cgcgccgtcg gggccgaccc ggccgagccg gagccggtgg ccacggacgc
    19801 gggcgccctg gtggcgctgc gggtggcgta ccggggcagg ctcgtgcacc tggccgcccg
    19861 tgacctcacc ggcgaggcca ccctccagga ggtcacggcc gagctgtccg agctcgccgg
    19921 cgccgcgctg gaggccgcgc tcgccgtcgc ccgcgccgag gtggacgccg ccggggtgcg
    19981 cctcgccgtc atcggcatgg gcaagtgcgg cgcgcgggag ctcaactaca tcagcgacgt
    20041 cgacgtcgtc ttcgtcgccg agccgcgcga gggcgccgac gagaccaagg ccctgcgcac
    20101 cgccacccgc ctggcccagg ccatgatgcg ggcctgcacc gccaccaccc ccgagggcgc
    20161 cctgtgggag gtcgacgcgg gcctgcgccc cgagggccgc tccggcccgc tggtgcgcac
    20221 gctcgccagt cacctcgcct actaccggcg ctgggccaag acgtgggagt tccaggcgct
    20281 gctcaaggcc cgcccggtgg cgggcgacct ggagctgggg gaggcctacg tccaggccgt
    20341 caacgacctg gtctggacgg cggccacccg cgagcacttc gtcgaggacg tgcaggccat
    20401 gcgccgccgg gtcgaggcgc acgtccgcgc cgagggcgag cggcagctca agctgggccc
    20461 cggcggcctg cgcgacatcg agttcgccgt ccagctcctg cagctcgtgc acgggcggct
    20521 cgacccgctg ctgcgccgcc gcgccacgct gcccgcgctg gccgccctgg cgcgcggcgg
    20581 ctacgtcggc cgcgacgact cccgcggcct ggccgaggcg tacgcgttcc tccgccaggt
    20641 cgagcacctg ctccagctcc accggctgcg ccgcacgcac atcgtcccca ccgccgaggc
    20701 cgacctgcgc aggctgggcc gcgcgctcgg catgcaggcc gacccggtgg gcgagttcac
    20761 cgcccggtgg cggcggcacg ccagggaggc gcggcggctg cacgagaagc tgttctaccg
    20821 gccgctgctc caggccgtct cgcggctgca ggagtcggag gcgcggctgt ccccggccgc
    20881 cgcggcggcc cggctggagg cgctcggcta cgtcgacccg gcgggcgcgc tgcggcacat
    20941 cgccgccctc accgccggcg tgtcgcggcg ggccgcgatc cagcgcacgc tgctgccggt
    21001 catgctcggc tggttcgccg aca
//
