LOCUS       NZ_JAKRKC020000002     20456 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Actinomadura luzonensis strain ATCC 31491 Contig00006, whole genome
            shotgun sequence.
ACCESSION   NZ_JAKRKC020000002
VERSION     NZ_JAKRKC020000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura luzonensis
  ORGANISM  Actinomadura luzonensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Genome draft of Actinomadura sp. ATCC 31491
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Genome draft of Actinomadura sp. ATCC 31491
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
REFERENCE   4  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
REFERENCE   5  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
REFERENCE   6  (bases 1 to 3173380)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. v1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 89.6x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022664455.2-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 18:46:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,232
            CDSs (total)                      :: 10,155
            Genes (coding)                    :: 10,004
            CDSs (with protein)               :: 10,004
            Genes (RNA)                       :: 77
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 151
            CDSs (without protein)            :: 151
            Pseudo Genes (ambiguous residues) :: 0 of 151
            Pseudo Genes (frameshifted)       :: 36 of 151
            Pseudo Genes (incomplete)         :: 126 of 151
            Pseudo Genes (internal stop)      :: 3 of 151
            Pseudo Genes (multiple problems)  :: 14 of 151
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:31:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 599026
            Orig. end                         :: 619482
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAKRKC020000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20456
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="1"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20456
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20456
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10456](-)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10456)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            54..293
                     /locus_tag="MF672_RS32970"
                     /old_locus_tag="MF672_032970"
     CDS             54..293
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MF672_RS32970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MF672_032970"
                     /product="hypothetical protein"
                     /protein_id="WP_242378623.1"
                     /transl_table=11
                     /translation="MLIATLRDARLRALRWGSGALVAAYAIPVAFWQLGPSDAPSLTKY
                     MNPAVTAILIAAGVAVALAFHVQRRRAAAQPTAD"
     misc_feature    63..76
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 21.26"
                     /tool="antismash"
     misc_feature    511..525
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.88"
                     /tool="antismash"
     misc_feature    568..581
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    complement(654..669)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.77"
                     /tool="antismash"
     misc_feature    complement(697..711)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.34"
                     /tool="antismash"
     gene            908..9286
                     /locus_tag="MF672_RS32975"
                     /old_locus_tag="MF672_032975"
     CDS             908..9286
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033679.1"
                     /locus_tag="MF672_RS32975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_032975"
                     /product="DNRLRE domain-containing protein"
                     /protein_id="WP_242378624.1"
                     /transl_table=11
                     /translation="MISLAAAPPAAAQSTTPVPGEPNLISRAAGWLAGTVSGWFAEDPK
                     GEMRPAAGPVTLPGRDGEVSVKQAEPAPPGKRVKEKSGQRWRFGTVYELEDGRSQAEIS
                     TRPVYFQDPSGAWQPIDTSIGAAEGDGFAHGNDKTGFQSRFGDKSDKLARIGLGKQQVT
                     FGVAGAARQITPQVNGSTVTYPGLWEGADLVYTLTASGVSEHLKLTRPPAPGTSFAFTV
                     KTGGDLQATQNGDGSISFAGADGKRVFTIPRPFMIDSQADAASPYGKRTGAITQELVQG
                     QGGEVAITLKPDTAWLAAPERAWPVLIDPTLKINDWAIDVYDTYVSNAAATTNFADSWK
                     LPVGKTSAGLNRALLFFGAPGAKILPIGTRIDQARLEMYFDQALGESAAVTLAAHEITD
                     DSWTWDPLGTTWNHQPSFAATAASTVTRAPGELSRWHSFDVTAMVNGWYSSIEAPMAGI
                     LVKAANEAKTAPVGGVAYQAMDDFGPADPLTVDPVAHPRLLVTFGKPSVRLEQPTLATS
                     VGASLSWSAYQDPTPGDASDDLVEYRLRHECPSACDRSSNTSGGDYDSLVVTLPPQVTS
                     YVDTSSGAEPDAAADPAYSHRADYWVEAVLKNGQVVPSQKVRVFLPKPGYVTKTLYAGT
                     DTTLASGEPGTGHDVLAGQKRLQIGNTATALANTRAVLTFDDYAAQIPADAQISQARLS
                     LWQATATGSGASFTAHKLTRAFDENATWASPWTTPGGDFEATALDTVTGLTDTAGWRPW
                     TVTDAAKSWTATPAANHGLLIKVANEAGTAKQSAQFLAGETSEPLLRPKLAVTYADTTT
                     PSSFYAPGTPERLDAGASADISVMVQNTTTESWPAASTKLSYHWKLPDGTDISTADSQL
                     KTALPYDLAPGAAVTVTAKVRAPATTSNLAEGAVLVWDVQDTVTNNWKSATHHLPELPQ
                     QIRIDSPTSDLLGLEKFYAYTGKNTGAGASALVNPYAGNVVWGYNAFSNPSRGAQTFVR
                     MTYNSLDTSTASLGYGWSLQTSTLPKLGSQLQFHPPGQRWPTQVRLTDGDGTTHVWTLD
                     THGNTNCLPNTCDYKHPRGVHLYLQRVPESAAAPDRYSRDPARQWVFTKPDRTQFFFDD
                     EGFQSAIVDKNGNTMSFTYERRKSNNKPTKFLQYITDATGRKTLSLDYYEKGQDYTYID
                     DETWQPVQDTKLTNPHIIDNVEQITDIAGRRLTFAYTGKGLMARMIDGAGDEQAKTFAF
                     RYDATQGNKNVKLVKVTDPRGNDTDLKYYEAPVDPKDLWKAQTLTDRLDGVTTFDYVDP
                     DGPQGGVINATVTDPLTHATKYELDAYGRPHLITNAKNETTRLEWDPDHNVTDLFEANQ
                     AHTTWTYDDKTGYPRTIKDAEANQNGTNPTTLTYQAGLNGYTADLTEKTSPEGRTWQFT
                     YDANGNLKTVTDPLGVQTATAGDYTTKYDYDGNGLLIKVTDANGNPTSYGDYDPSGYPK
                     TITDAYGVETPTQGDHTTSFDYDVRGNVLSVTDALGKKTTQTYDIFKRPLESKVPKDQD
                     TGVFITTPAPVYDRNDNITKSTAPNGAVATAAYDAADQLIESVLPKDSDTGPQRKATFA
                     WDLAGNLKTQTEPKGNLPGANPAEFTTTYLYNQIYQLTDVLNADQHKITYTYDNVGNTT
                     TVIDPRKNATPDTGDYTATYTYDLNHQVKTTKDAAGHQTKTDYDLDGLVIGQTDQENNK
                     TITTYDKRGDVIETKVPHADTGGTIKYVTTRFEYDQAGNQTKTITPRGVETADDDTDFL
                     AETRYDKLNRPVEEIYPFDKDDPVYNKPDSVLYTYDAVSQLKEISLPPSHGQTIRNVSK
                     MTYWDNGWSRTTTDPWDIKTTYDYNKLGLQTNRTVTSAGGSSQRAMDWDYYPDGKLKTH
                     SDDGVPLGLDVVLEDNSDTGQTVATGTWTATSGGTSSSSIIGPRLATTATDGFVGYDYA
                     TAPAGTGQSSFTWNLATPAAGTYKVAVQYPAGATATNAKYTVKHDGGTAVVVVDQTKNP
                     GTWVELGSYTFTAGTTHSVTLTDEANGTVVADAVKLVRDTAGTSDTEKKDFAYTYDANA
                     NLTRIDDNSPTAKIDLWDISYTNLNQIQQIQEKLDGALKNTTTYAYNENSAVTVRTHDK
                     TVATYGYDVRDLVNQVVNKKSATDPSPKTTTYTYTPRGERLTETKANGNTVTYDYFLSG
                     VLRHSIEKKPNATIVAEHTLGYQSNLHRASDHAKIQNADNHGAYLEHDYAYTYDPRDRI
                     AKTVKTPVAGGTAQTETYSHDPNSNVWEEEVLGKKTTFTYDRNRLMTSVTGGATATYTY
                     DPYGRLRTVQGGGKTWEKYTYDGFDHVIQHEKLGADGTTNTVTKYTYDPLDRTTTKTEK
                     EGTANARTTTYSYLGLSGEVLDEEVAGKLTKSFQYSPWGERLSQVKVNADSTEENSYYG
                     YNPHTDVEQITSDAGDTRATYGYTAYGKNDDKLFTGVDKPDPVDPTAKEEYNPYRFNAK
                     RWDNSTGMYDMGFRDYNPGLNRFLNLDSYDGALADLALGLDPWTANRYAFAGGNPITGI
                     ELDGHDPYGCSPTSPDCVSKNNAIARKEAGLPPRDRSGNGGTYEARPSLLLSPMKPVNP
                     PTRTAPKAPTQTAPKGFWGRLGGVLGLLLMLCGDSAQTDCSDEPERQPQPLPSPSSSNS
                     TSIQQDDSKEQVAPDTNVLIDAYDRHLEAAVDAAIGDRGVVILGPVRDEFLDTDDAQEL
                     AARKNWLKQFMDKHQGVYGGGASVSAVKSLQAENAWELDKWRSAAPPILKDKDARVLAA
                     AMAHNRIKILTSDKKFANWLTWIAYPHELLSLR"
     misc_feature    9278..9280
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9333..9689
                     /locus_tag="MF672_RS32980"
                     /old_locus_tag="MF672_032980"
     CDS             9333..9689
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MF672_RS32980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MF672_032980"
                     /product="hypothetical protein"
                     /protein_id="WP_242378625.1"
                     /transl_table=11
                     /translation="MPAFNRLRLPEPFVCPNCHQGYEQILQFTYGYAWQFDYEIGDTVN
                     WRKEPRADEGVPGAGRVYVEAILERACPHCGHDVPWPRSAFEIELRKDVIVAARPGIHH
                     VTHTRQDRWVVAEP"
     gene            complement(10001..10456)
                     /locus_tag="MF672_RS32985"
                     /old_locus_tag="MF672_032985"
     CDS             complement(10001..10456)
                     /GO_function="GO:0016755 - aminoacyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04539.1"
                     /locus_tag="MF672_RS32985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_032985"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_242378626.1"
                     /sec_met_domain="CDPS (E-value: 4.9e-27, bitscore: 92.5,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIAGQALVEVGPCNAASAAILARCEHIVLLVSPGNSYFSAARLA
                     ATFAWAVRNVGDVHVLVSDAEMTAATYLARGRPEQDAYRKARDDIRQMAARIRRARDSA
                     GTPDLRISEVADWTGNAAYRHALAYARQAIADPRYIALRVRPPDRAG"
     gene            complement(10511..11368)
                     /locus_tag="MF672_RS32990"
                     /old_locus_tag="MF672_032990"
     CDS             complement(10511..11368)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MF672_RS32990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MF672_032990"
                     /product="hypothetical protein"
                     /protein_id="WP_242378628.1"
                     /transl_table=11
                     /translation="MPPTVPRAHRRAARLLALPLAVVPATDTIPFRLLPAAQADPSACT
                     VNGSKVTGQVITGTAGDDTITCPGGVPQNTTINALAGNDTITAHGAPGNHGTVNGGDGA
                     DTIKATGGEGGSHDGGYGNAGTITGGSDNDIITLTGGKGGSAGGSSRGGPANVNRVEGG
                     PGADQITAIGGDAATGRTDPLHSGYGGDGNWSRGRLLGGDGADTIKATGGNSTTSRGGS
                     GNANGAKIHGGNGNDSITAARGTGTQSGLSNDAHSEVDGGEGVDTCTFVPKDPPKVYNC
                     EKKR"
     misc_feature    11463..11475
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            complement(11511..12332)
                     /locus_tag="MF672_RS32995"
                     /old_locus_tag="MF672_032995"
     CDS             complement(11511..12332)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012738.5"
                     /locus_tag="MF672_RS32995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_032995"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_242378630.1"
                     /transl_table=11
                     /translation="MRRLRLGTYAAVAVFAVPFLLPFYLLLRNALMTRRELGSLEWHWW
                     PETVTFQGFADAFGNEAVPLAHALGNSALISSISAPVSTLLASMAGYALARVPVAAARP
                     VFFFIIATMMVPGAATFIPTFVVVGSMGGVNTLWGLIAPGLFSAFAVLLFRGFYLRFPR
                     ELEDAGRVDGLGHLGLYARLALPNSGALFASLGILSFIEHWNAFLWPLVIGQDPEYWTV
                     QVALSTNLNQQAVNLPALFAGALVAILPLVALFLLAQRWIVRGVLLTGVKG"
     gene            complement(12329..13300)
                     /locus_tag="MF672_RS33000"
                     /old_locus_tag="MF672_033000"
     CDS             complement(12329..13300)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083758.1"
                     /locus_tag="MF672_RS33000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_033000"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_242378632.1"
                     /transl_table=11
                     /translation="MTSTAAPATVRARRRRRAAARGPAWRAFILLTLPMVAGLFLFKYV
                     AIGWGLLLSFNDARGTISLGAWNGLENYRRLLSDPAFTRSLVTILLFTLFIVPVTFGLA
                     LGLAVLVNRLRRGRALFRTTFFVPAAVSYVVGALVWKMSLFSGTPSGVANSLAYLVGHE
                     DAIGWVATVDPPLYWVVLVTVRLWLQTGFYMILFLAGIQQVPAQLYEAARVDGAHSEWT
                     LFRHITWPMLRNTSVAVTLLLIINAFQAFDEFYNILASNLSGLGGADGRTPLIYLFQTA
                     LGEQNYGAGSAGAFLVTVLIVAFTLLQGRFAGFGRGDEEEAR"
     gene            complement(13297..14583)
                     /locus_tag="MF672_RS33005"
                     /old_locus_tag="MF672_033005"
     CDS             complement(13297..14583)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024808.5"
                     /locus_tag="MF672_RS33005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_033005"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_242378634.1"
                     /transl_table=11
                     /translation="MDRPLTRRGLLKGSVLFVAGAAVSACGGDPLARTRPSSASGGAPK
                     ITLSHWYHEYGEQGTQQAAMRYAADFTKANPDTAVKVSWIPGDYATKWTAAVLTADGPD
                     VYEVNDVSPNMVKAGQVTPLDDVLGAEKPDFDPKVLAPYTWGGRAYAVPMIIDPMLLFY
                     RKSLFQKAGVAVPASFPELLAAAKKLTAGKQKGLFAGNDGVGPLNTMLPWSNGNLLIDD
                     RKIIYNDPKVVEALAGLKQLYDAKTTLQGYSTDWWDPGALINGAAAMQWVGLWAVPGLT
                     DALGDDFDAFALPPYGPGGRAVVNMGGWVQVVNGKSRNLDAAKKYVRWLWVENTAAQTD
                     WSLAYGFHVPPRTSAAAKADKLTSGPAKTVMDAVAAHGVKQPALWTAEVRQPYTDAVTA
                     IVKKGADPEKTLAEAAKRSQDILDQVPVL"
     misc_feature    14680..14697
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.59"
                     /tool="antismash"
     misc_feature    14691..14708
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.22"
                     /tool="antismash"
     misc_feature    14697..14710
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.08"
                     /tool="antismash"
     misc_feature    complement(14699..14712)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.19"
                     /tool="antismash"
     gene            14813..15949
                     /locus_tag="MF672_RS33010"
                     /old_locus_tag="MF672_033010"
     CDS             14813..15949
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012742.5"
                     /locus_tag="MF672_RS33010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_033010"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_242378636.1"
                     /transl_table=11
                     /translation="MTAPNRVTIRDVARRAGVSVATVSRVLGGEYPVLAATRNKVVRAV
                     RELDYVPNAHARALSAARPGAVAIVVNSVAVPYYALIAQGVEEQAAQEGRLSLICTTGG
                     DTGRELSVVQLMREQRAEAVILVGSVVVDEEYRKRMTEYAHALAAAGSRLVLCGRPPLG
                     DGVPALVVNFDNTGGAHAVTAHLLSAGHRRILYLGLRPGHSTSDSRVAGYRAALAEYGV
                     PADPGLEVPAEFDRESGYAAMRRLLAAGPPRFTAVFAGNDVVAAGAIQALREHGLRVPE
                     DVSIVGYDDVPPAQDLGLTTVHLPHDELGRAAVRLALGRRTPGSPLPSPLPAPLLAPRP
                     GAAGPPEAGGPDGDGPARVLTLGTHIVVRSSVRRLGPR"
     gene            15946..17673
                     /locus_tag="MF672_RS33015"
                     /old_locus_tag="MF672_033015"
     CDS             15946..17673
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019552.5"
                     /locus_tag="MF672_RS33015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_033015"
                     /product="heparinase II/III family protein"
                     /protein_id="WP_247815530.1"
                     /transl_table=11
                     /translation="MTPPALPARPAGAAGRLGRLAREIREEAERARGTPAPALTAALWR
                     RFADTGDRLAYESVYFERRRRLSALLLAAHLTDAPDDRPDDRPDDRPDDRPDGRRDGRW
                     DPALDDLLWSVCEERTWALPAHAPPPGAPAGRHVVDLFAAETAHTLAEATVLPGVRLGP
                     RVRARVRAEVDRRVLAPFQARRMWWETCAHNWAAVCAGAAGMAALALGSARLPALLPRV
                     EAALAAFRSGAGRDGACLEGPDYWAYGFGYFVYFAEALRAHTGRDLLDDPHVRAMAGYP
                     AAIDLGGGHRPAFADSAGRGAYPAGLLDRLAERLDVPVPEQPAEPSFHDDPCYRWAHLS
                     RTLWWSTGAARRPPAPQAFLPDAGIVAARAPGSAFAAKGGHNDEPHNHLDLGHFVLRAG
                     GATVLDDLGAPEYTRGYFGPHRYRTPQASAAWHSVPLIDGTPQLPGRERAARVAAHVPG
                     EPLLFALDLTAAYGTPRLARFVRTFTWRPGRLDVADDFAFHGGECRVEEVFVSRARPAV
                     RDGVVRWGPVVLDVPEPWRARAEELRVRGHDGARETVHRVRLTAAVPSGPHRFVFRVT"
     gene            complement(17670..19532)
                     /locus_tag="MF672_RS33020"
                     /old_locus_tag="MF672_033020"
     CDS             complement(17670..19532)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017589847.1"
                     /locus_tag="MF672_RS33020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_033020"
                     /product="DUF2264 domain-containing protein"
                     /protein_id="WP_242382277.1"
                     /transl_table=11
                     /translation="MRWLRELDDRRLSPHTGWTRDHWAALADHLLLSARRHASPSHARF
                     SFPGEPGGYGPDVDGLEGFARTFLAAGFRVAGEGGRDPHGHLEWYARGLAAGTDPASPD
                     RWVRLDEHDQAKVEAASIALVLHLTRPWLWDRLDDRVRERVVEYLAPAVGAAYPPINWV
                     WFQIVVEQFLASVGGPHSRADLEAGLALTDGFAREDGWYSDGDRRAYDHYAGWALHFYP
                     LLWAEMAAGDPAADGRVAGYLGRLRRYLEDAVHLVGADGSPLLQGRSLTYRFAAAAPFW
                     TGARAGLAAPAPGLLRRAASGIARHFVRHGAPGDDGLLTLGWHGPWRPIAQSYSGPGSP
                     YWAAKGLYGLTLPADHPVWTAVEEPLPVERGDFRRVVRAPGWLVSGTRDDGVVRVVNHG
                     TDHATPGDHRADSPLYARLGYSTATSPVLAGPHAADPLDQSVTLLDGDGRPSHRTGFGT
                     LFAARLPSGTAVGASRWRAHWVRPDPDVPDHGYGRGGDVTLGPSITVVSALRGAWEVRL
                     VRVDPECAFPLRVGGWPAPPGRTSAVVPGPGLDLADTAVARDATPLSGHTAIPWCGTAA
                     AAEPGRWYTATILLAGGAPGRAPVVVGRCVTWSDGTEDVLELPS"
ORIGIN
        1 cggtcctcgt cctcggcggc ttcgccctgc tctccggcat ccccatcgcc atcgtgctga
       61 tcgccaccct gcgtgatgcc cgcttgcgcg ccctgcgctg ggggagcggg gcgctcgtcg
      121 ccgcctacgc catcccggtg gcgttctggc agctggggcc gagcgacgcg ccgagcctga
      181 ccaagtacat gaaccccgcc gtcaccgcga tcctcatcgc cgccggcgtg gccgtcgccc
      241 tcgccttcca cgtccagcgc aggcgcgccg cggcgcagcc cacggccgac tgacgccagc
      301 cacaccccgg agcgggcggg cggatgccga aggctccgtg cggacccgtg cgagtttcgc
      361 gcgacgggag gacgggggct gcgcgcaagg ctaaatactg agcgttgccg aacgtgcggc
      421 gtccgccaga aggcgagagg taactcagag ccagcgcgcc gatccgtagc gtggatttct
      481 cctggtcagc ccgctaagcg gctttctgtg aagttgctgg caattgcatc acggacaggt
      541 aacgagcgct cgtgaccacc tgcatcgttt acgcagagca atgttggcgc tcggtcggac
      601 atccttcctg ctcggccgtg atcttcccag ttggatccaa gtccgcgacg ctcgcgcaca
      661 ggtgttcgag aaaagtggta tgccaccttc cgtaatcatt gaccgaatat gcctgtttgt
      721 ggcgagatac gggtgttttg ctccgaggat ctttagatcc tccttatccg cggcctcctg
      781 ggctgcggag atgtggagtg cgctcgtgtc cttatcgtcc ctgtcatcga aacgacctgc
      841 atcaggccga cgtggccacc acccgcgctt acgcaagctg accagcgcga ccgcggcctc
      901 cgcgctggtg atctcgctgg ctgcggcccc acccgccgcc gcgcagagca ccaccccggt
      961 tccgggtgag ccgaatctga tctcccgggc ggccggctgg ctggccggca cagtgtcggg
     1021 ctggttcgcc gaggatccca agggtgagat gcggccggcg gccggcccgg tcacgctgcc
     1081 cggacgcgac ggtgaggtgt ccgtgaagca ggccgagcct gcgccgccgg gcaagcgcgt
     1141 caaggagaag agcggtcagc ggtggcggtt cggcaccgtg tacgagctgg aggacggccg
     1201 ctcgcaggcg gagatctcga cccggccggt gtatttccag gacccgtccg gggcctggca
     1261 gccgatcgac accagcatcg gcgcggccga gggcgacggg ttcgcgcacg gcaacgacaa
     1321 gacaggcttt cagagccgtt tcggtgacaa gagcgacaag ctggcgcgga tcggactggg
     1381 caagcagcag gtcaccttcg gcgttgcagg cgcggcgcgg cagatcactc cgcaggtcaa
     1441 cggctcgacc gtcacctatc cgggcctgtg ggagggtgcc gatctggtct acacgctcac
     1501 cgcctcgggc gtgagcgagc atctcaagct gaccaggccg cccgcgccgg ggacgagttt
     1561 cgccttcacc gtcaagaccg gcggcgacct gcaggccacc cagaacggcg acggctcgat
     1621 ctccttcgcc ggcgccgatg gcaagcgggt ctttacgatc ccgcgccctt tcatgatcga
     1681 cagccaggcg gatgccgcct ccccgtacgg caagcgcacc ggcgccatca cccaggaact
     1741 ggtccagggc cagggcggcg aggtggcgat cacgctgaag ccggacacgg cctggctggc
     1801 cgcgccggag cgcgcctggc cggtgctgat cgaccccacc ctgaagatca acgactgggc
     1861 gatcgacgtc tacgacacct acgtcagcaa cgccgcggcg accaccaatt tcgccgactc
     1921 ctggaagctt ccggtgggca agacctcggc ggggctgaac cgggcgctgc tgttcttcgg
     1981 cgccccgggt gcgaagatcc tgcccatcgg cacccggatc gaccaggccc gtctggagat
     2041 gtacttcgac caggcgctgg gtgagagcgc ggcggtgacg ctggccgcgc acgagatcac
     2101 cgacgattcc tggacgtggg acccgctcgg caccacgtgg aaccaccagc cgagtttcgc
     2161 cgccaccgcc gcctcgaccg tgacccgggc gccgggtgag ctgtcacgct ggcactcctt
     2221 cgacgtgacc gcgatggtca acggctggta ctccagcatc gaggcgccga tggccggcat
     2281 tttggtcaag gcggccaacg aggcgaagac cgccccggtg ggcggggtcg cctaccaggc
     2341 gatggacgac ttcggcccgg ccgacccgct gaccgtcgac ccggtcgcgc atccgcggct
     2401 gctggtgacg ttcggcaagc cgtcggtgcg gctggagcag ccgacgctgg ccacctcggt
     2461 gggcgcctcc ctgtcgtgga gcgcctacca agatcccacc cccggtgacg cctctgatga
     2521 tctggtggag taccggctgc gccacgagtg cccgtcggcg tgtgaccgca gctccaacac
     2581 cagtggcggc gactacgaca gtctggtggt gacgctgccg ccgcaggtga cctcctacgt
     2641 cgacaccagc agcggcgccg agcccgacgc cgccgccgac cccgcctaca gccaccgcgc
     2701 cgactactgg gtggaggcgg tgctgaagaa cgggcaggtg gtgccgtcgc agaaggtgcg
     2761 ggtgttcctg cccaagcccg gctacgtcac caagaccctg tacgccggca ccgacaccac
     2821 cctggcctcg ggcgagccgg gcaccgggca cgacgtgctg gccggccaga agcggctgca
     2881 gatcggcaac accgccaccg ccctggccaa cacccgcgcg gtgctcacgt tcgacgacta
     2941 cgccgcccag atcccggccg acgcgcagat cagccaggcc cggctgtcgc tgtggcaggc
     3001 caccgccacc ggcagcggcg cctccttcac cgcccacaag ctcacccgcg ccttcgacga
     3061 gaacgccacc tgggccagcc cgtggaccac gcccggcggc gacttcgagg ccacggcgct
     3121 ggacaccgtc accgggctga ccgacaccgc tggctggcgg ccatggacgg tcaccgacgc
     3181 cgccaagtcc tggaccgcca ccccggccgc caaccacggc ctgctgatca aggtcgccaa
     3241 cgaggccggc acggccaagc agtcggccca gttcctggcc ggcgagacca gcgagccgct
     3301 gctgcgcccg aagctggccg tcacctacgc cgacaccacc acgccgtcct cgttctatgc
     3361 tcccggcacc cccgagcggc tggacgcagg cgcgagcgcc gacatctcgg tcatggtgca
     3421 gaacaccacc accgaatcct ggcccgcggc ctcgaccaag ctgtcgtatc actggaagct
     3481 gcccgacggc accgacatct ccaccgccga cagccagctc aagaccgccc tcccctacga
     3541 cctggcgccg ggtgccgccg tcaccgtgac cgccaaggtc agggcccctg cgaccacgag
     3601 caacctggcc gagggcgcgg tgctggtgtg ggacgtgcag gacaccgtca ccaacaactg
     3661 gaagtcggcc acccatcatc tgccggagct gccgcagcag atccgcatcg actcccccac
     3721 ctcggacctg ctggggctgg agaagttcta cgcctacacc ggcaagaaca ccggcgccgg
     3781 cgcgagcgcg ctggtcaacc cgtacgcggg caacgtggtg tggggctaca acgccttctc
     3841 caacccctcc cgcggcgcgc agacgttcgt ccggatgacc tacaacagcc tcgacacctc
     3901 aacggcctcc ctcggctacg gctggagcct gcagacctcg acgctgccca agctgggctc
     3961 gcagctgcag ttccacccgc ccggccaaag atggcccacc caggtcaggt tgaccgacgg
     4021 cgacggcacc acccacgtat ggacgctcga cacccacggc aacaccaact gcctgcccaa
     4081 cacctgcgac tacaagcacc cccgcggcgt gcacctgtac ctgcagcgcg tgccggaatc
     4141 cgcggccgca cccgaccgct actcacgcga cccggcccgc cagtgggtgt tcaccaagcc
     4201 cgaccgcacc cagttcttct tcgacgacga aggcttccag tccgcgatcg tcgacaagaa
     4261 cggcaacacc atgtcgttca cctacgaacg gcgtaagtcc aacaacaagc cgaccaagtt
     4321 cctgcagtac atcaccgacg ccaccggccg taagacgctg agcctggact actacgaaaa
     4381 gggccaggac tacacctaca tcgatgacga gacctggcag ccggttcagg acaccaagct
     4441 gaccaacccg cacatcatcg acaacgtcga gcagatcacc gacatcgccg gccgcaggct
     4501 caccttcgcc tacaccggca agggcctgat ggcccgcatg atcgacggcg ccggggacga
     4561 gcaggccaaa accttcgcct tccgctacga cgccacccag ggcaacaaga acgtcaaact
     4621 ggtcaaggtc accgacccgc gcggcaacga caccgacctg aagtactacg aggcaccggt
     4681 cgaccccaag gacctgtgga aggcccagac cctgaccgac cggctcgacg gcgtcaccac
     4741 cttcgactac gtggaccccg acggaccgca gggcggcgtg atcaacgcca cggtcaccga
     4801 cccgctcacc cacgccacca agtatgagct ggacgcctac ggccggccgc acctcatcac
     4861 caacgccaag aacgagacca cccgcctgga atgggacccc gaccacaacg tcaccgacct
     4921 gttcgaggcc aaccaggcgc acaccacctg gacctacgac gacaagaccg gctacccgcg
     4981 gacgatcaag gacgccgagg ccaaccagaa cggcaccaac ccgaccacgc tgacctacca
     5041 ggccggcctg aacggctaca ccgccgacct gaccgagaag accagccccg aaggccgcac
     5101 gtggcagttc acctacgacg ccaacggcaa cctcaagacg gtcaccgacc cgctcggcgt
     5161 ccaaaccgcc acagccggtg actacaccac gaagtacgac tacgacggca acggcctgct
     5221 gatcaaggtc acggacgcca acggcaaccc caccagctac ggcgactacg acccctccgg
     5281 ctaccccaag accatcaccg acgcgtacgg cgtcgagacg cccacgcagg gcgaccacac
     5341 cacctcattc gactacgacg tacgcggcaa cgtcctgtcg gtcaccgacg cgctgggcaa
     5401 gaagaccacc cagacctacg acatcttcaa acgccccctg gagtccaagg tccccaagga
     5461 ccaggacaca ggcgtcttca tcaccacccc ggcccccgtc tacgaccgca acgacaacat
     5521 caccaagtcc accgccccca acggcgcggt ggccaccgcg gcctacgacg cggccgacca
     5581 gctgatcgaa tcggtgctgc ccaaggactc cgacaccggc ccgcagcgca aggccacctt
     5641 cgcctgggac ctggccggca acctgaagac ccagaccgag cccaagggca acctgcccgg
     5701 cgcgaacccg gccgagttca ccaccaccta cctctacaac cagatctacc agctcaccga
     5761 cgtactcaac gccgaccagc acaagatcac ctacacctac gacaacgtcg gcaacaccac
     5821 cacggtcatc gacccgcgca agaacgccac cccggacacc ggcgactaca ccgcgaccta
     5881 cacctacgac ctcaaccacc aggtcaagac caccaaggac gcggccggac accagaccaa
     5941 gaccgactac gacctggacg gcctcgtcat cggccagacc gaccaggaga acaacaagac
     6001 gatcaccacg tacgacaagc gcggcgacgt gatcgagacc aaggtcccgc acgccgacac
     6061 cggcggcacg atcaagtacg tcaccacccg cttcgagtac gaccaggccg gcaaccagac
     6121 caagacgatc acgccccggg gcgtggagac cgccgacgac gacaccgact tcctcgccga
     6181 gacccgctac gacaagctga accggccggt cgaggagatc taccccttcg acaaggacga
     6241 cccggtctac aacaagccgg acagcgttct ctacacctac gacgccgtct cccagctgaa
     6301 ggagatctcc cttccgccct cgcacgggca gaccatccgc aatgtctcga agatgaccta
     6361 ctgggacaac ggctggtcca ggaccaccac cgacccgtgg gacatcaaga ccacctacga
     6421 ctacaacaag ctgggcctgc agaccaaccg caccgtcacc agcgcgggcg gctcctccca
     6481 gcgggcgatg gactgggact actaccccga cggcaaactc aagacccact ccgacgacgg
     6541 cgtcccgctc ggcctggacg tggtcctgga ggacaactcc gacaccggcc agacagtggc
     6601 gaccggcacc tggacggcca cctcgggcgg cacctcctcc tccagcatca tcggcccccg
     6661 gctggcgacg acggcaaccg acgggttcgt cggctacgac tacgccaccg cccccgccgg
     6721 caccggccag tcatccttca cctggaacct ggccaccccg gccgcgggca cctacaaggt
     6781 cgccgtgcaa tacccggccg gcgccaccgc caccaacgcc aaatacaccg tcaagcacga
     6841 cggcggcacc gccgtggtgg tcgtggacca gaccaagaac cccggcacct gggtcgagct
     6901 cggcagctac accttcaccg ccggcaccac ccacagcgtc accctcaccg acgaagccaa
     6961 cggcaccgtc gtggcggacg cggtcaagct ggtccgcgac accgccggca ccagcgacac
     7021 cgagaagaag gacttcgcct acacctacga cgccaacgcc aacctgaccc ggatcgacga
     7081 caactcaccc accgccaaga tcgacctgtg ggacatctcc tacaccaacc tcaaccagat
     7141 ccagcagatc caggaaaagc tcgacggcgc cctgaagaac accacgacct acgcctacaa
     7201 cgagaacagc gccgtcaccg tccgcaccca cgacaagacg gtggccacct acggctacga
     7261 cgtacgcgac ctggtcaacc aggtcgtcaa caagaagtcc gccaccgacc cgtcgcccaa
     7321 gacgaccacc tacacctaca ccccgcgcgg cgaacgcctg accgagacca aggccaacgg
     7381 caacaccgtc acctacgact acttcctgtc cggcgtcctg cgccactcga tcgagaagaa
     7441 gcccaacgcc acgatcgtgg ccgagcacac cctcggctac cagagcaacc tgcatcgcgc
     7501 cagcgaccac gccaagatcc agaacgccga caaccacggc gcctacctcg aacacgacta
     7561 cgcctacacc tacgaccccc gcgaccgcat cgccaagacc gtcaagaccc cggtcgccgg
     7621 cggcaccgcg cagaccgaga cctactccca cgaccccaac agcaacgtgt gggaggagga
     7681 ggtcctcggc aagaagacca ccttcaccta cgaccgcaac cgcctgatga cctcggtcac
     7741 cggcggagcc accgctacct acacctacga cccctacggc cgcctgcgca ccgtccaggg
     7801 cggcggcaag acctgggaga agtacaccta cgacggcttc gaccacgtca tccagcacga
     7861 gaaactcggc gccgacggca ccaccaacac cgtcaccaag tacacctacg acccgctcga
     7921 ccgcaccacc accaagaccg agaaggaagg caccgcaaac gccaggacca ccacctactc
     7981 ctacctcggc ctgtccggcg aggtcctgga cgaggaggtg gccggcaaac tcaccaagtc
     8041 cttccagtac agcccgtggg gcgagcgcct gtcccaggtg aaggtcaacg ccgacagcac
     8101 ggaagagaac tcctactacg gctacaaccc gcacaccgac gtcgaacaga tcacgtccga
     8161 cgcgggcgac acccgggcca cctacggcta caccgcctac ggcaagaacg acgacaagct
     8221 tttcaccggc gtcgacaagc ccgaccccgt ggaccccacc gccaaggagg agtacaaccc
     8281 ctaccgcttc aacgccaagc gctgggacaa ctccaccggc atgtacgaca tggggttccg
     8341 cgactacaac ccgggcctca accgcttcct caacctcgac agctacgacg gcgccctggc
     8401 ggacctggca ctcggcctcg acccctggac cgccaaccga tacgccttcg caggcgggaa
     8461 cccgatcacc ggcatcgagc tcgacggaca cgacccgtac ggctgctcac ccacctcacc
     8521 ggactgcgtg agcaagaaca acgccatcgc ccgtaaggag gccgggcttc cgccccggga
     8581 ccgaagcggc aacggaggca cctacgaggc caggccaagc ctgctgcttt caccgatgaa
     8641 gccggtcaat ccgcctaccc gaacggcccc gaaggcgccg acccagaccg cgcccaaggg
     8701 cttctggggg agactcggcg gcgtactggg cctgttgctc atgctgtgcg gcgactccgc
     8761 acagaccgac tgctcggacg agcccgaacg gcaaccccag cccctgccca gcccgagcag
     8821 ctccaacagc acgagcatcc agcaggacga cagcaaggaa caggtggcgc cggacacgaa
     8881 cgtgttgatc gacgcctacg atcggcatct ggaggccgcg gtcgacgccg ccatcgggga
     8941 tcgcggtgtg gtcatcctcg gtcccgtcag ggatgagttc ctggacaccg atgacgcaca
     9001 ggaactcgcc gcgcggaaga attggctgaa acagttcatg gataagcacc agggagttta
     9061 cggtggcggc gcatcggtgt cggcggtaaa gtccctgcag gccgagaacg cgtgggagct
     9121 ggacaagtgg agatcggctg cacctcctat cctcaaggac aaggacgcac gcgtcctcgc
     9181 cgcggcgatg gcccacaacc ggataaagat cctcacgagc gacaagaagt tcgcgaactg
     9241 gctgacctgg atcgcttatc cgcacgagct tctctcatta cgttagtgcc agctggaaac
     9301 agacaggcga gacaagacag gccacgagaa atatgccggc attcaacagg ctgagactcc
     9361 ctgagccgtt cgtctgcccg aactgccacc agggctacga gcagatcctt cagttcacct
     9421 acggctacgc ctggcagttc gactacgaaa tcggcgacac ggtcaactgg cgaaaggagc
     9481 cacgcgcgga cgaaggcgtt ccgggagctg ggcgggtata tgtggaagcc atcctcgaaa
     9541 gggcatgccc ccactgcggc cacgatgtgc cgtggccccg ctcggccttc gagatcgagc
     9601 tgagaaagga tgtgatcgtc gccgctcgcc caggaatcca ccatgtgacg cacacgagac
     9661 aggatcgatg ggtggtggcg gagccgtgag gtgagcgcat cgcggtgacg tcctggaggg
     9721 ccgggcaccc gtccggccct ccatgcgcgt cctcggcgcg tcaacgcgta cggcgcgggc
     9781 gttgcccggc gcacacccgc gtacccggca cgaaccggcc gggctccctg agccggggca
     9841 ggccgcgcgg ctgacgccga gccgatcagc aatctgctgg acggtgtagc gccgctcacc
     9901 gtccgatccc tgcatgtgca gccgtgggcc aggaccatgc cgctccttcg aggactcgcc
     9961 gcgggcagcc gtagcgccct ccgccggcgt ggacgatcga tcagccggcc cggtcgggcg
    10021 ggcggacgcg cagcgcgatg tagcgggggt cggcgatggc ctgccgcgcg taggccagcg
    10081 cgtggcggta ggcggcgttg cccgtccagt cggcgacctc gctgatccgc aggtcaggcg
    10141 tgccggccga gtcgcgggcc cgccggatcc tggccgccat ctggcggatg tcgtcgcggg
    10201 ccttgcggta ggcgtcctgc tccggccggc cccgggccag gtaggtcgcc gcggtcatct
    10261 ccgcatcgga gaccagcacg tgtacgtccc cgacgtttcg gacggcccag gcgaacgtcg
    10321 ccgccaggcg agcggcggag aagtaggagt tgcccgggct gaccagcaac acgatgtgct
    10381 cacacctggc caggatcgcg gcgctcgcgg cgttgcacgg tccaacctcg accagcgcct
    10441 gtcctgcgat gtccaccctg ccacccccta cgagcaccta cccacgtggg tgctgaccgc
    10501 gagcaggggg ctacctcttc ttctcgcagt tgtagacctt gggcgggtcc ttgggaacga
    10561 aggtgcacgt gtcgacgccc tcgccgccgt ccacctcgga gtgggcgtcg ttcgacaatc
    10621 ctgactgcgt gcccgtgccc ctggcggcgg tgatggagtc attgccgttg ccaccgtgga
    10681 tcttggcgcc gttcgcgttg cccgagcctc ccctgctggt ggtgctgttg ccgccggtgg
    10741 ccttgatggt gtcggcgccg tcgccgccga gaagtcttcc tctggaccag ttgccgtcgc
    10801 ctccgtagcc gctgtggaga ggatcggtgc gaccggtggc ggcgtcgccg ccgatggcgg
    10861 tgatctgatc ggcgcctggg cctccctcga ccctgttcac gtttgccggc ccgcctcttg
    10921 agctgccacc tgcggagccg cccttgccgc cggtcaaggt gatgatgtcg ttgtcggaac
    10981 cgccggtgat ggtgccggcg ttgccgtacc cgccgtcgtg ggatccgcct tcgccgccgg
    11041 tggccttgat ggtgtcggcg ccgtcgccgc cgttgacggt gccgtgattg ccgggggcgc
    11101 cgtgggcggt gatcgtgtcg ttgccggcca gggcgttgat ggtggtgttc tgggggacgc
    11161 cgccggggca ggtgatggtg tcgtctccgg cggtgccggt gatgacctgg ccggtgactt
    11221 tgctgccgtt gacggtgcag gcgctggggt cggcctgtgc cgcgggcagc aggcggaatg
    11281 ggatggtgtc ggtggccggc accacggcca gaggcagtgc gagcaggcgt gcggcgcggc
    11341 ggtgggctcg ggggacggtc gggggcatgt gcagctccga tggctgaagg cgttcgcgcc
    11401 gcaagcagcg gggagcggat cgggacctgg ctcacggtgc ggcgctcacg tggtcgtcgc
    11461 ccgggccgtt gtcaccgccg gtggggtgac ggcgccaggc acggaggggg tcagcctttg
    11521 acgccggtga gcaggacgcc cctgacgatc cagcgctggg cgagcaggaa gagcgcgacc
    11581 agcggcagga tggccaccag cgccccggcg aacagcgccg gcaggttcac ggcctgctgg
    11641 ttgaggttgg tggacagcgc gacctggacc gtccagtact ccgggtcctg cccgatgacc
    11701 agcggccaca ggaacgcgtt ccagtgctcg atgaacgaca ggatgccgag cgaggcgaac
    11761 agcgcgcccg agttcggcag cgccagccgg gcgtacaggc cgaggtggcc gaggccgtcc
    11821 acccggcccg cgtcctccag ctcgcgcggg aagcgcaggt agaagccgcg gaacagcagc
    11881 acggcgaacg cgctgaacag gccgggcgcg atcagccccc acaacgtgtt gaccccgccc
    11941 atcgagccga ccacgacgaa cgtcgggatg aacgtggccg cgcccggcac catcatcgtg
    12001 gcgatgatga agaagaacac cggccgcgcg gccgccaccg ggacacgggc cagcgcgtag
    12061 cccgccatcg aggccagcag cgtgctcacc ggcgcggaga tcgacgagat cagcgccgag
    12121 ttgccgaggg cgtgcgccag cggcacggcc tcgttgccga aggcgtcggc gaacccctgg
    12181 aacgtcaccg tctccggcca ccagtgccac tccagcgacc ccagctcgcg ccgcgtcatg
    12241 agcgcgttgc gcagcagcag gtagaacggc agcaggaacg gcaccgcgaa cacggccacc
    12301 gccgcgtacg tgcccagccg cagcctcctc atcgcgcctc ctcctcgtcg ccgcggccga
    12361 agccggcgaa gcggccctgc agcagcgtga acgccacgat cagcacggtg accaggaacg
    12421 cccccgccga cccggcgccg tagttctgct cgccgagcgc ggtctggaac aggtagatca
    12481 gcggcgtgcg gccgtccgcg ccgccgagcc cggacaggtt ggaggccagg atgttgtaga
    12541 actcgtcgaa cgcctggaac gcgttgatga tcagcagcag cgtgaccgcc accgacgtgt
    12601 tgcgcagcat cggccaggtg atgtgccgga acagcgtcca ctccgagtgg gcgccgtcca
    12661 cccgcgcggc ctcgtagagc tgggcgggca cctgctggat gccggccagg aacaggatca
    12721 tgtagaagcc ggtctgcagc cacagtcgta cggtgaccag caccacccag tacagcggcg
    12781 ggtccacggt ggccacccag ccgatcgcgt cctcgtgccc caccaggtac gccaggctgt
    12841 tggccacccc cgacggcgtg ccgctgaaca ggctcatctt ccacaccagc gcgcccacca
    12901 cgtacgacac ggccgccggc acgaagaagg tggtgcggaa cagcgcccgc ccccgccgca
    12961 gccggttgac cagcaccgcg aggcccagcg ccagcccgaa cgtcaccggc acgatgaaca
    13021 gcgtgaacag caggatcgtc accagcgacc gggtgaaggc cgggtccgac agcagccgcc
    13081 ggtagttctc cagcccgttc caggcgccca ggctgatcgt gccgcgggcg tcgttgaagc
    13141 tgagcagcag cccccagccg atggcgacgt acttgaacag gaacagcccg gccaccatcg
    13201 gcagcgtgag caggatgaac gcgcgccagg cgggcccgcg ggcggcggcc cgccgccggc
    13261 ggcgggcgcg gaccgtggcg ggggcggccg tgctcgtcat agcacgggca cctggtcgag
    13321 gatgtcctgc gagcgcttgg cggcctcggc cagcgtcttc tccgggtcgg cgcccttctt
    13381 gacgatcgcg gtgacggcgt cggtgtaggg ctggcgcacc tcggcggtcc acaacgccgg
    13441 ctgtttgacg ccgtgcgcgg cgacggcgtc catgacggtc ttggcggggc cgctggtcag
    13501 cttgtcggcc ttggcggcgg cgctggtcct cggcgggacg tggaagccgt aggcgaggct
    13561 ccagtcggtc tgcgcggcgg tgttctccac ccacagccag cgcacgtact tcttggccgc
    13621 gtccaggttg cggctcttgc cgttgacgac ctgcacccag ccgcccatgt tgaccacggc
    13681 gcgcccgccg gggccgtacg gtggcagcgc gaaggcgtcg aagtcgtcgc cgagggcgtc
    13741 ggtcaggccc ggcaccgccc acaggcccac ccactgcatg gccgccgcgc cgttgatcag
    13801 cgctcccggg tcccaccagt cggtcgagta gccctgcagg gtggtcttgg cgtcgtagag
    13861 ctgcttgagc ccggccagcg cctcgaccac cttcgggtcg ttgtagatga tcttgcggtc
    13921 gtcgatcagc aggttgccgt tcgaccaggg cagcatcgtg ttgagcgggc cgacgccgtc
    13981 gttgccggcg aacaggccct tctgcttgcc ggccgtcagc ttcttcgccg ccgcgagcag
    14041 ctcggggaag ctcgccggca ccgccacccc ggccttctgg aacagcgact tgcggtagaa
    14101 cagcaacatc gggtcgatga tcatgggcac cgcgtaggcc cggccgcccc acgtgtacgg
    14161 ggccagcacc ttcgggtcga agtcgggctt ctccgcgccc agcacgtcgt ccagcggggt
    14221 cacctggccg gccttcacca tgttcgggct gacgtcgttg acctcgtaca cgtcggggcc
    14281 gtcggcggtc agcacggcgg cggtccactt ggtggcgtag tcgccgggga tccacgagac
    14341 cttgaccgcg gtgtcggggt tggccttggt gaagtcggcc gcgtaccgca tcgccgcctg
    14401 ctgggtgccc tgctcgccgt actcgtggta ccagtggctg agggtgatct tgggagcgcc
    14461 cccggaggcg gacgacggcc tggtcctggc gaggggatcg ccgccgcagg ccgagacggc
    14521 ggcgccggcg acgaagagca cggatccctt gagcagtccg cggcgcgtga gtggtctgtc
    14581 catcggggcc acctctctgg ggggaaggat cggggccgat gtcaggtaac cggttacttc
    14641 agacgtcgtg agccggacgg tagacgcgat cgtccagagg agtcaatgtc ttgttaactt
    14701 ttcgttacaa acgcgctcag agcagggttg acggcgaaaa cgggatctcc tagcgtccag
    14761 ggcatcggtc aggtaaccgg ttacctgcga gacccgccga caggaggccc gcatgaccgc
    14821 gcccaaccgt gtcaccatca gggacgtggc caggcgggcc ggcgtctcgg tggccacggt
    14881 gtcccgcgtg ctgggcggcg agtacccggt gctcgcggcc acccgaaaca aggtcgtccg
    14941 ggcggtgcgc gagctggact acgtccccaa cgcccacgcc cgcgccctgt cggcggcccg
    15001 gcccggcgcc gtcgccatcg tcgtcaacag cgtcgccgtg ccgtactacg cgctcatcgc
    15061 gcagggcgtc gaggagcagg ccgcccagga gggacggctg tcgctcatct gcaccaccgg
    15121 cggcgacacc ggccgcgagc tgtccgtcgt gcagctcatg cgcgagcagc gcgccgaggc
    15181 cgtcatcctg gtcggcagcg tggtcgtgga cgaggagtac cgcaagcgca tgaccgagta
    15241 cgcccacgcg ctcgccgccg ccggctcccg cctggtgctg tgcgggcggc cgccgctggg
    15301 cgacggggtg ccggcgctcg tcgtcaactt cgacaacacc ggcggcgcgc acgcggtgac
    15361 cgcccacctg ctgtcggccg gccaccgccg gatcctctac ctggggctgc ggcccggcca
    15421 ctccacctcc gacagccgcg tcgccggcta ccgggcggcg ctcgccgagt acggcgtgcc
    15481 cgccgacccc gggctggagg tgccggccga gttcgaccgc gagtccgggt acgccgccat
    15541 gcgccgcctg ctggccgccg ggccgccccg cttcaccgcc gtcttcgccg gcaacgacgt
    15601 ggtcgccgcg ggcgccatcc aggcgctgcg cgagcacggg ctgcgggtgc ccgaggacgt
    15661 ctccatcgtc ggctacgacg acgtgccccc ggcgcaggac ctcgggctga ccacggtgca
    15721 cctgccgcac gacgagctgg gacgcgccgc ggtccgcctg gccctcggcc gccgcacccc
    15781 cggctcgccc cttccctccc cccttcccgc gcctcttctc gcgccccggc ccggcgcggc
    15841 ggggccgcct gaggcgggcg ggccggacgg cgacggtccg gcgcgggtcc tgacgctcgg
    15901 gacgcacatc gtcgtgcgca gctccgtccg gcggctcggc ccccggtgac cccgcccgcg
    15961 ctgcccgccc gtcccgccgg cgcggcgggg cggctcggcc ggctggcgcg ggagatccgc
    16021 gaggaggccg aacgggcccg ggggacgccc gcgcccgcgc tgaccgccgc cctgtggcgg
    16081 cgcttcgccg acaccggcga ccggctcgcc tacgagtccg tctacttcga acgccgccgc
    16141 cgcctgtccg ccctcctcct ggccgcccac ctgaccgacg cccccgacga ccggcccgac
    16201 gaccgccccg acgaccgccc cgacgaccgg cccgacggcc gccgcgacgg ccggtgggat
    16261 cccgcgctcg atgatctcct ctggtcggtc tgcgaggagc gcacctgggc gctccccgcc
    16321 cacgccccgc cccccggcgc acccgccggc cggcacgtgg tggacctgtt cgccgccgag
    16381 accgcgcaca ccctggccga ggcgaccgtc ctgcccggcg tccggctcgg cccgcgcgtg
    16441 cgcgcccgcg tccgggccga ggtggaccgg cgggtgctcg cgcccttcca ggcccgccgc
    16501 atgtggtggg agacctgcgc gcacaactgg gccgccgtct gcgcgggcgc ggccgggatg
    16561 gccgccctgg ccctcggctc ggcccgcctc cccgcgctcc tgccccgcgt ggaggcggcc
    16621 ctcgccgcgt tccgctccgg cgccggccgg gacggcgcct gcctggaggg tcccgactac
    16681 tgggcctacg gtttcgggta cttcgtctac ttcgccgagg cgctgcgcgc gcacaccggc
    16741 cgcgacctcc tcgacgaccc gcacgtgcgc gccatggccg gctatccggc cgcgatcgac
    16801 ctcggcggcg ggcaccgccc cgccttcgcc gactcggccg ggcgcggcgc gtacccggcc
    16861 gggctgctgg accgcctggc cgagcggctg gacgtgcccg tgcccgagca gccggccgag
    16921 ccgtccttcc atgacgaccc ctgctaccgc tgggcgcacc tgagccgcac cctgtggtgg
    16981 agcaccggcg ccgcccgccg cccgcccgcg ccgcaggcgt tcctcccgga cgccgggatc
    17041 gtcgccgccc gcgcccccgg cagcgccttc gccgccaagg gcggccacaa cgacgagccg
    17101 cacaaccacc tcgacctcgg ccacttcgtc ctgcgcgcgg gcggcgcgac cgtgctggac
    17161 gacctgggcg cgcccgagta cacccgcggc tacttcggcc cgcaccgcta ccgcaccccg
    17221 caggcgtccg ccgcctggca ctccgtcccc ctcatcgacg gcacgccgca gctcccgggg
    17281 cgcgagcgcg cggcgagggt cgcggcgcac gtccccggcg agccgctgct gttcgccctc
    17341 gacctcaccg ccgcctacgg cacgccgcgc ctggcccggt tcgtccgcac cttcacctgg
    17401 cgtcccggcc ggctcgacgt cgccgacgac ttcgccttcc acggcggtga gtgccgggtg
    17461 gaggaggtgt tcgtctcgcg cgcgcgtccc gcggtccggg acggcgtcgt ccggtggggg
    17521 ccggtggtgc tcgacgtgcc ggagccgtgg cgggcgcggg cggaggagct gcgggtccgc
    17581 ggccacgacg gcgcccggga gacggtccac cgggtacgcc tgaccgccgc cgtcccgtcc
    17641 ggtccgcacc gtttcgtctt ccgcgtcacc taggagggga gctccaggac gtcctcggtg
    17701 ccgtcggacc aggtcacaca ccgccccacg accacggggg cgcgcccggg ggcgcccccg
    17761 gccagcagga tcgtggccgt gtaccacctg ccgggctcgg cggcggccgc cgtcccgcac
    17821 cacgggatcg ccgtgtggcc ggacagcggg gtggcgtccc gcgcgacggc cgtgtccgcc
    17881 aggtcgagcc ccgggccggg gacgacggcg gaggtccggc ccggcggcgc cggccagccc
    17941 cccacccgca gcgggaacgc gcactccggg tccacccgga ccagccgcac ctcccaggcg
    18001 ccgcgcaggg ccgacacgac cgtgatcgac ggcccgagcg tgacgtcgcc gccgcgcccg
    18061 tagccgtggt cggggacgtc cgggtccggg cgcacccagt gggcccgcca ccgggacgcg
    18121 cccacggcgg tgccgctcgg caggcgcgcg gcgaacagcg tgccgaaccc ggtgcggtgg
    18181 ctgggccggc cgtcgccgtc gaggagcgtg accgactggt ccagggggtc ggcggcgtgc
    18241 ggcccggcca ggacgggcga ggtcgcggtg gagtagccga ggcgggcgta cagcggcgag
    18301 tcggcgcggt ggtccccggg cgtggcgtgg tcggtgccgt ggttgacgac gcggaccacg
    18361 ccgtcgtccc gggtgccgga caccagccag ccgggcgccc ggaccacccg ccggaagtcg
    18421 ccgcgctcca ccggcagcgg ctcctccacg gccgtccaca ccgggtgatc ggcgggcagc
    18481 gtcagcccgt acaggccctt ggccgcccag tagggggagc cggggccgga gtacgactgg
    18541 gcgatcggcc gccatggccc gtgccagccg agcgtgagca ggccgtcgtc gcccggcgcg
    18601 ccgtgccgga cgaagtggcg ggcgatgccg gaggcggccc ggcgcagcag cccgggcgcg
    18661 ggcgccgcca gcccggcccg cgcgcccgtc cagaagggcg cggccgccgc gaaccggtag
    18721 gtgaggctgc gcccctggag cagcggcgag ccgtccgcgc cgaccaggtg gacggcgtcc
    18781 tctaggtagc gccgcagccg ccccaggtag ccggcgacgc ggccgtcggc ggccgggtcg
    18841 ccggcggcca tctcggccca cagcagcggg tagaagtgca gcgcccagcc ggcgtagtgg
    18901 tcgtaggcgc gccggtcgcc gtcggagtac cagccgtcct cgcgggcgaa gccgtcggtg
    18961 agcgcgagcc cggcctcgag gtccgcgcgg gagtgcgggc cgccgacgga ggcgaggaac
    19021 tgctccacga cgatctggaa ccagacccag ttgatcggcg ggtacgcggc cccgaccgcc
    19081 ggtgccaggt actccaccac ccgctcgcgc acccggtcgt cgagccggtc ccacagccac
    19141 ggcctggtca ggtgcagcac cagcgcgatg gacgccgcct ccaccttggc ctggtcgtgc
    19201 tcgtccagcc gcacccagcg gtcgggggag gcggggtcgg tgcccgccgc caggccgcgc
    19261 gcgtaccact ccaggtggcc gtgcgggtcg cggccgccct cgcccgccac ccggaacccg
    19321 gccgcgagga acgtccgggc gaagccctcc agcccgtcca cgtccggccc gtagccgccc
    19381 ggctcgccgg ggaaggagaa acgcgcgtgg gacggggagg cgtgccggcg ggccgacagc
    19441 agcaggtggt cggccagcgc cgcccagtgg tccctggtcc agccggtgtg gggggacagc
    19501 cgccggtcgt ccagctcccg cagccagcgc atgggggcct cccgccgatc gtggaccccg
    19561 gcgatgctgg caccaccgcg tcccgcccgt caagcgcccg ccggcggcgc tcgcggctca
    19621 cccgcgtcgc cttcccggct cacccgcgtc gccctcccgg ctcacccgtg ccgggaccgg
    19681 atccctgaca ccagctccct gacccgggcc agcgccggcc ccgggtcgcg ggccgacagc
    19741 acgctgtgcg tggccccggc cgcgtggcgc agcgtgccgg ccaggtcggc gacgagaccg
    19801 ccccggcgtt ccgcggcggc ccgccgcagg tcgccctcca gccagtggta gcgcaccccc
    19861 ggccgggccc gcgcgggcgg cacgtcctgg ccggtggcca gggccgccca ggcggccggc
    19921 aggttcgcgc cggccgcggt ggcgagcgcc atcgagccgt agaagcggcc gttcaggtcg
    19981 atgagccggg gcgcgccgtc ctccggcact acgaactgca gttgcgccag cccgaaccag
    20041 ccgagggcgg cgagcagccg gacggccggg ccggcgatcc tcgggtccac ccgcacggtc
    20101 tcggcgcggc agctcgcgcc ggcctcgggc ggccagatcc gcgaggcgac ctgcatgcag
    20161 tcggccacga cccgcgcctc gcgggtgacc acggcgcagt aggccatcag gcggcccgcg
    20221 tggaactcct cgacgcgggg ctcgccgccg agcccgcgca cctcgtccac ccggcggcgg
    20281 gcggccgcgc cgtcgtgcac gaccagggtg tcgatccgcg gcggggcgcc cggccggtcc
    20341 ggctgcgcgt gcagccgggc cttcaccacg agcggccggt gctcgccggc gaccgcgtcc
    20401 gggtcgaggg cgcgggccgt cgccaggccg atcgacctgg cggcgtcgca cagcga
//
