LOCUS       NZ_JAKRKC020000001     22454 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Actinomadura luzonensis strain ATCC 31491 Contig00003, whole genome
            shotgun sequence.
ACCESSION   NZ_JAKRKC020000001
VERSION     NZ_JAKRKC020000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura luzonensis
  ORGANISM  Actinomadura luzonensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 6358096)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Genome draft of Actinomadura sp. ATCC 31491
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6358096)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
REFERENCE   3  (bases 1 to 6358096)
  AUTHORS   Shi,X. and Du,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2022) School of Medicine, Zhejiang University, 866
            Yuhangtang Road, Hangzhou, Zhejiang 310058, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. v1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 89.6x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022664455.2-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 18:46:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,232
            CDSs (total)                      :: 10,155
            Genes (coding)                    :: 10,004
            CDSs (with protein)               :: 10,004
            Genes (RNA)                       :: 77
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 151
            CDSs (without protein)            :: 151
            Pseudo Genes (ambiguous residues) :: 0 of 151
            Pseudo Genes (frameshifted)       :: 36 of 151
            Pseudo Genes (incomplete)         :: 126 of 151
            Pseudo Genes (internal stop)      :: 3 of 151
            Pseudo Genes (multiple problems)  :: 14 of 151
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:31:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1577764
            Orig. end                         :: 1600218
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAKRKC020000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22454
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="5"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22454
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22454
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12454](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12454)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            89..2113
                     /locus_tag="MF672_RS07470"
                     /old_locus_tag="MF672_007470"
     CDS             89..2113
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012895338.1"
                     /locus_tag="MF672_RS07470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007470"
                     /product="adenylate/guanylate cyclase domain-containing
                     protein"
                     /protein_id="WP_242380836.1"
                     /transl_table=11
                     /translation="MPSADPAPYLPPATQPVRGVVWAIHLVLPMLGLWLLLANDKINIP
                     WQHNPSHFWSILAVAGVNVALGLMISEAARRRGDARLFLVSMVFLSSAGFFFMHGLATP
                     GFILRTGSLGFDAGQQVGLSVAALFAFASALPLGERAAGRVLAAQHFVRAALLGFMLVW
                     GLTSLTPGLTPLSEPPAEAPVPWLAWGSLPGLLAYAAASVMMFLIHRRRPSAMLISLIT
                     AYALLAESMVAGMSQHNWHLSWWEWHLLLTLAFVFVAYSSYLQFRREGSSAGLFDSVAL
                     SATVRRIRQDYDRALEELVEHVRRGEPLAATRLSGKFRLNEGQAAVLDRAGRALAEERE
                     LSVRLAALVDVSGRTKVGLPENELLASSLERVRQAYGDVRIALVADGRTQVGSREYAFT
                     GDEPIRRDHLLAFPLTVKGKLAGVLEVPIGRTSQDEALAATLAGQLSISLENARLYQEL
                     HTLFHQYMSPDVAHALLADPAQAALGGELRELTALFADLKGFTTFSEKVTPGEIVEMLN
                     RYHTAAVPCILDNGGTIVQFVGDALLALFNAPAAQADHARAACRAALAMQQAAAEVAEE
                     MAWKRVDDVPWPTFRVGVNTGPALVGNIGSPELRGFNAMGDCVNVAARLEGVAVPGTVV
                     IGETTLRHLGEGASVRPLGDLSLKGKEELVTAYVLTDLA"
     gene            2147..2809
                     /locus_tag="MF672_RS07475"
                     /old_locus_tag="MF672_007475"
     CDS             2147..2809
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0030552 - cAMP binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544220.1"
                     /locus_tag="MF672_RS07475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007475"
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="WP_242380837.1"
                     /transl_table=11
                     /translation="MDPEPGEFLSMLTDEEAQALRAAGRIRRWDRGTAVMNEGDLADWV
                     LVLLDGRVKVSSHTSSGTEVVLAVRGPGGLLGDMSAIDGSPRSATVTALEPITGIVVRD
                     FPAFLETHGRIAVLLMKLVTGRLRDSDRKRIEYGAFDTTGRVATRLIELAERYGEKTNG
                     GVRVALPLSQDELAGWTGASREAVSKALRTLRDRGLIETGRRRVVIHDLDGLRKRAR"
     misc_feature    complement(2816..2825)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.9"
                     /tool="antismash"
     gene            2854..4323
                     /locus_tag="MF672_RS07480"
                     /old_locus_tag="MF672_007480"
     CDS             2854..4323
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544221.1"
                     /locus_tag="MF672_RS07480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007480"
                     /product="MFS transporter"
                     /protein_id="WP_242380838.1"
                     /transl_table=11
                     /translation="MVAVTPHDDSRLRYAWKVCSVTSLGLVLIGIAGSTLNVALPAVVR
                     HFHADATESGWILLSFLLVNTASLVFFGRVADLLGRREVYLAGFALFTVASLLAGLSPD
                     VWFLIAMRVVQAVGAAMILANGTVIITDAFPPERLSQGMGVYIGTLSVAQLAGPTVGGL
                     IAETAGWQWIFWVNVPAGLIALAWGAAILRKVPRGPRQPVDGLGNVLLFAALSALLLAL
                     SETGSRGVGSPVVLAGAGVFAVLVPLIVLAERRAANPVLDLRLFGGRLLAYANAASFCN
                     ALARSALILVVALYFQAARGLDAFAAGLSVLPVPVGIGLASPLVGLLGRRVSPYALSIG
                     GATLSALGLGTLTLTAGPGTPYWVTGIGLFVAGCGSGTFLTGNTTQVMRALPSGSLGVV
                     NGFRVMIMNVGIVISVGLSLSVLTASVGPELRAQVYAGTLSRLSPVAVGQLMEGFQRAY
                     GVLFAVAVAGALLAALARGQSSAESLDSTSR"
     misc_feature    3427..3429
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4284..5030)
                     /locus_tag="MF672_RS07485"
                     /old_locus_tag="MF672_007485"
     CDS             complement(4284..5030)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544222.1"
                     /locus_tag="MF672_RS07485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007485"
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="WP_242380839.1"
                     /transl_table=11
                     /translation="MTFELICEIEPPTKPDLKHVRHQIGTMSKIAHAFLIPDNHIGRAT
                     VSSVAVAHEVEAMGGRGIACLNSRDRNLLGFRRDLLTAAAYGVDQFLFVYGDKPTSGNR
                     TSDLTVRSMLDEARAFSPDLRLGAAAGLRSLPSWKRAADFLFLQVSYSVEAQLRWREAH
                     PADVPVYAGVMVLASERHARTLAAAIPDIDLPDDLVRRVAADRMAGVEAACEQVLALRE
                     SGAFAGVHLVPVSRYRDVESRLSALL"
     gene            complement(5027..5674)
                     /locus_tag="MF672_RS07490"
                     /old_locus_tag="MF672_007490"
     CDS             complement(5027..5674)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014906.5"
                     /locus_tag="MF672_RS07490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007490"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_242380843.1"
                     /transl_table=11
                     /translation="MGKLTAQAIAERALEIGDAEGLDAVTIRRLAAELGVTPMALYWHF
                     KNKDQLLAGMADHLIAGFAPQPADERPWQEQLRDLTVGLIRTLRAHRCARDVFERVGQV
                     AVPNYLAVWNRALGLGRTAGFSADESCLISQYLLRSAIAIADAPGHSRDEQEVRARRAG
                     LQALPPERYPFIVEMAAPLAGGMDPELYDTFGVDLVLAGIEALAARRIQSEP"
     misc_feature    complement(5679..5694)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.41"
                     /tool="antismash"
     gene            5790..7200
                     /locus_tag="MF672_RS07495"
                     /old_locus_tag="MF672_007495"
                     /pseudo=""
     CDS             5790..7200
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="MF672_RS07495"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007495"
                     /product="MFS transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTYLDNNVGNVALPTIQRELGLTVSGLEWIVSSYILVFAGLMLAG
                     GRLADVFGARGVFLAGLGVFTAASLTAGLATSGGLLIAARGAQGVGAALLTPTALALIG
                     QIFPDPAERDRRAVHGARAGGGRLHQRAPALGLDLPGQRADRGGHGRARAVGGQALRAG
                     PAAQPGPARAGHLGAGAGGAHVRAHRGRRGRVDVAGDPGRVRGRPGGGRGVRGDRVAGR
                     RADAGDGAVPVAGVHRRTAHQRHLVVRGVRDLLLQRPVAAERARLLPHRGGRLVRADGP
                     GHGRRGAAVAAGEPAVRHRPDRRDRPGAHGHRRLPALPGRRRGRLRRRRPVVHPVRRRR
                     RPDGAADRRRPRRPAGRALGGGRRHAERLPRGLRPARRHRPRGDPERPAERERAARAAR
                     LPGRVRVHAGDRGGRDAGRHPDRPVGPPGPPRPRPGRGPDGPRAGRRRKPDLSGEREDR
                     PDHPLAALVAEV"
     gene            complement(7143..7562)
                     /locus_tag="MF672_RS07500"
                     /old_locus_tag="MF672_007500"
     CDS             complement(7143..7562)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.5"
                     /locus_tag="MF672_RS07500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007500"
                     /product="ATP-binding protein"
                     /protein_id="WP_242380840.1"
                     /transl_table=11
                     /translation="MEHTFLAGIADPLLFPSMARDTVCRWIGARAHDLETVTSELVTNA
                     VRHGLGPMPDAGYVRLKLTTESRRCELLVTDPGRSPGEPAMGLPDNDPSPDPDPDPGVE
                     RLRGLVLVDLLTGGLWGHFRNERRERVVWAVLPLA"
     misc_feature    complement(7558..7571)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.89"
                     /tool="antismash"
     gene            7692..8513
                     /locus_tag="MF672_RS07505"
                     /old_locus_tag="MF672_007505"
     CDS             7692..8513
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.4"
                     /locus_tag="MF672_RS07505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007505"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_242380841.1"
                     /transl_table=11
                     /translation="MAENGQDPSLKAWQEYAERLHRYRSDQGLSQQRLAERIPYSEAAV
                     GHVERLIRKPSHGLTKELERVFGLQGELMELLPEIHGVGPKWFREWPRVEKLAHTIRTS
                     EPMLIPGLLQTERYASHTFLGEPGASVEEIETAVGFRLRRQRIFARARPPVYSALIDES
                     VLRRPVGGGAVMREQLQKLTDVLNPPYVTVRIIPLSAGLTAGCLGAFEIATLLDGGPTH
                     AYVESAEEGRVTSRAKTVQALTVRWEALSGMAHPVDRSRAIIREVMESYEQ"
     gene            8503..8721
                     /locus_tag="MF672_RS07510"
                     /old_locus_tag="MF672_007510"
     CDS             8503..8721
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.5"
                     /locus_tag="MF672_RS07510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007510"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_242380842.1"
                     /transl_table=11
                     /translation="MSSERGLRTGVWTKARASGGNGGSCVEVMRLADGGVLVRDSKDGG
                     QGPELSFTRAEWLAFLDGAGKGEFDLS"
     gene            8791..9782
                     /locus_tag="MF672_RS07515"
                     /old_locus_tag="MF672_007515"
                     /pseudo=""
     CDS             8791..9782
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612357.1"
                     /locus_tag="MF672_RS07515"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007515"
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MARGDLTDEEWSLIEPHLPLGERGPIPDLRRLFNAVMWRFRTGSP
                     WRDLPTEYGPWSTAYDRFRSWALNGVFEQLMQAMIAEAAARGQADLDLVSVDSTTARAH
                     HHAAGMVLDGELSAALEEAAEREKGLRQRGKTPATTATTKGATGTGTDEGGCDADTGSG
                     "
     misc_feature    8842..8844
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(9861..9995)
                     /locus_tag="MF672_RS07520"
                     /old_locus_tag="MF672_007520"
     CDS             complement(9861..9995)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038159.1"
                     /locus_tag="MF672_RS07520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007520"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_242371943.1"
                     /transl_table=11
                     /translation="MTLLDLQALPPERDPKGGDQAAAQSHLSITGCAADSGLSLLLCD"
     gene            complement(10001..12454)
                     /gene="lanKC"
                     /locus_tag="MF672_RS07525"
                     /old_locus_tag="MF672_007525"
     CDS             complement(10001..12454)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017559021.1"
                     /locus_tag="MF672_RS07525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007525"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_242371942.1"
                     /sec_met_domain="micKC (E-value: 2.6e-235, bitscore: 781.8,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.9e-06, bitscore:
                     25.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRDYHLFCQADPLFYDVPPAADDFPCAPLPPGWLRHDHHEWRSC
                     LPPGPGLPAQGWKIHVSGRPDNAERLIAAVRAYCLPRGLAFKFLRGPRAVLARNAKYAP
                     RAGSGKLLTLYPRDEAELERVCAELGGLLEGEPGPYILSDLRIAAGPLYVRYGAFVPRW
                     CRSADGERVPAIEDPAGALVPDPRGPVFALPPWVDLPPFLAPHLAAREAVTVGALPYEI
                     EAALHHSNGGGLYRARRRDDGEPVVLKEARPHAGFSADGSDAVTRLRHERNLLERLSGL
                     PAVPALDGYVTLGDHEFLAMELVPGITLSTALARRHPLTAEVGRERDVAGFTRWALRTH
                     GLVEQAVAELHRRGYVHGDLHLGNVLSRPDGSVTLIDYEAAFPVAERRRPAVAAPGFLA
                     PPGRAGADLDRHALAVLRLALFLPMPMLLQLDRGKAAHLADLVAEHFPVPEEWLREAVA
                     VIAPDRPPSRPRLAPDGPGRDAITRAILATATPGRADRLFPGDIAQFGPGGGLNLAHGA
                     AGVLYALHASGAGRFPGHERWLLDRVLTGRDVRPGFYDGLHGIAYALACLGRLPEALDV
                     LAAARRHDLTDCGHDLYGGLAGIGLNLLHFARLTARPDLREAAHLLAGRIGDDPPAQAG
                     LMHGASGPALLFLALYEDRGDPAYLDRAATALRHDLGRCVTDDDGLLQVDEGWRLMPYL
                     AGGSIGIGLVLRRYLRHRHDARFARALAGIRRVARSGFFVQPGLFSGRAGAVLALADDP
                     EHGPEQARRLAWHALPHRGGLAFPGEQLLRLSADLATGAAGVLLALAAAQHRRPASLPF
                     LDERR"
     misc_feature    complement(12510..12525)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            complement(12527..14404)
                     /locus_tag="MF672_RS07530"
                     /old_locus_tag="MF672_007530"
     CDS             complement(12527..14404)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017593937.1"
                     /locus_tag="MF672_RS07530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007530"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_242371941.1"
                     /transl_table=11
                     /translation="MSMEMTAWHQLYSMNNRPERRPLSRATLRRIGGFARPHRRKLALF
                     VLLSVVLAGLAVASPLLAGRVVDAIFNAEPLSAVVTVALAIAAIAVAEAGLGLLNRWLS
                     AGIGEDLILNLRTAVFDHVQRMPVAFFTRTRTGALVSRLNNDVIGAQRAFTDTLSGVVG
                     NLVTLALTLTAMVGISWQITLLALLLLPVFVLPARRMGARIARLRREAADHNAAMGTQM
                     TERFSAPGATLVKLFGRPARESAEFAARARRVRDIGVRSAMTQSAFVTALTLVSALALA
                     LVYGLGGFYALREQLQPGAVVSMAMLLTRLYAPLTALASARMDVMAAVVSFERVFEVLD
                     LKPLIEERPGARRVPDGPVAVEFDDVRFAYPSADKVSLASLEEVAVLDSRGGEEVLHGI
                     SFRAEPGQMVALVGSSGAGKSTIAQLLPRLYDVDAGAVRLGGVDVRELSFDAIRDTLGL
                     VTQDGHLFHDTIRANLLLARPEATEDDLWDALTRARLAALIASLPDGLDTVVGERGYRL
                     SGGERQRLTIARLLLAQPRVVILDEATAALDATSEAAVQAALGEALAGRTAVVIAHRLS
                     TIRAADLILVVEDGRIVERGTHAELLAAGGRYEELYRTQFDDPATVGVA"
     misc_feature    complement(14409..14423)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.31"
                     /tool="antismash"
     misc_feature    14426..14443
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     gene            complement(14440..16515)
                     /locus_tag="MF672_RS07535"
                     /old_locus_tag="MF672_007535"
     CDS             complement(14440..16515)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544225.1"
                     /locus_tag="MF672_RS07535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007535"
                     /product="PhoX family phosphatase"
                     /protein_id="WP_242371940.1"
                     /transl_table=11
                     /translation="MANLIGGGRRPLPLLSTPHKGGRSALTCQFRCGNACAHDVANTTD
                     NAYFGDVVKEALSRRGVLRAGALGALVAGVGVAGAAPALADEPEAAAAKGWTGGGNGGL
                     NFTPVAPSTEDALRIPDGYSSSVVARWGDPVLPDAPAFDFDNQTAEAQAKQFGYNCDYV
                     TLLPLGRDRALLWVNHEYTDESLMFRGYTGGATATEEQIKIALAAHGGSVVEIERAGNT
                     GQWKLVTKGRRRYNRRITAQTPMRFTGPAAGSDLLKTAADPEGRNPVGMLNNCSGGTTP
                     WGTVLTAEENIDQYFVNGDKVPEAQKPYIARYTITTGTPAGNRRFDRVEERFDLAKHPN
                     EANRFGWIVEIDPFDPDSTPIKRTALGRLKHEAANTTLSRDNHLVVYMGDDSRFEYIYK
                     FVSKNRYIPGFDRHNRTLLDEGTLYVAKFTGDSPAAEIDGTGKLPSDGAFDGSGEWLPL
                     VSGDKSYVEGMTAAEVLVYTRVAADRVKGGATKMDRPEDMERNPVTGGVYVALTNNTNR
                     TAAQVDEANPRPSNKHGHVLELVEKGNDAGQRTFAWSLPLVCGDPADPATYFAGYDKSK
                     VSPISCPDNVTFDRDGNLWISTDGNALGSNDGLFVMPVRGKERGHLRQFLTVPVGAETC
                     GPLVSEDQRSVFVAVQHPGEIDGASPDQPASRWPDGDQPRPAVAVVWHAKNKKIGS"
     gene            16628..17073
                     /locus_tag="MF672_RS07540"
                     /old_locus_tag="MF672_007540"
                     /pseudo=""
     CDS             16628..17073
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544226.1"
                     /locus_tag="MF672_RS07540"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007540"
                     /product="sterol carrier family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPPRKMDPEKLRAALDAQLVALDEPPYDGPAAALPGALVAAVLAA
                     YDRGLAPERDAARQAVTAHLLDRLAAAARGAPWRCACRRTRPCRRSPARATPAAPRPTS
                     WRPTGAPGSSWPSGGSPGRRRWPRERSPPAAHAPIWQSTCRCAT"
     gene            complement(17070..18032)
                     /locus_tag="MF672_RS07545"
                     /old_locus_tag="MF672_007545"
     CDS             complement(17070..18032)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MF672_RS07545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MF672_007545"
                     /product="DUF4190 domain-containing protein"
                     /protein_id="WP_242371939.1"
                     /transl_table=11
                     /translation="MTTPGDPNEPRPGQDPREGEEPGVPATPREGEEPIAPAPPVVPPP
                     HEPPREPPHEPPREPGPEPGPEPGPHPPHEPRPGERPGHPDLPAAPETPAPAAGEDAEA
                     TQAFPIPGATPAYPGWESAPPQDEQPPARPPAPSRYEEPRPEHPYGGGYTTPDRTPGRP
                     QGGPQGGGVPPHQEAVPGTSPSSPYGGPPGYPSPPYGYPGAPPYQYGDRPPQDRTGNGL
                     ATASLVLGVASPFLVFVCFTGLITAILSIVFGCVALARKAGKGRALAGIVISVLSLILF
                     AIVAIWFWNVVQDCAHLSGPAADRCFEERFPWMSGGRRG"
     misc_feature    18028..18043
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
     gene            18175..18903
                     /locus_tag="MF672_RS07550"
                     /old_locus_tag="MF672_007550"
     CDS             18175..18903
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MF672_RS07550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MF672_007550"
                     /product="hypothetical protein"
                     /protein_id="WP_242371938.1"
                     /transl_table=11
                     /translation="MLDESPYRPAELRERLRHVYWLGGGSGAGKSTIARRLAARHGLTV
                     YATDDVMPDHARRLTPEDAPQLSRFKDMDMDERWLNRSPRAMLDTFHWYRGEGFALIVS
                     DLLRLPPGRGVLAEGFRLLPHLVRPLLADPARAVWLLPTPAFRRAAFERRGWDIPRRTS
                     DPPRARDNLLERDRLFTDRLAAETRRLGLPAVGVDATLGEDELTDHVAGLMGLRPACGQ
                     VTARDVSPPRGASTEAADLD"
     gene            18909..20345
                     /gene="purF"
                     /locus_tag="MF672_RS07555"
                     /old_locus_tag="MF672_007555"
     CDS             18909..20345
                     /EC_number="2.4.2.14"
                     /GO_function="GO:0004044 - amidophosphoribosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009113 - purine nucleobase biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544228.1"
                     /locus_tag="MF672_RS07555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007555"
                     /product="amidophosphoribosyltransferase"
                     /protein_id="WP_242371937.1"
                     /sec_met_domain="GATase_7 (E-value: 1e-18, bitscore: 65.9,
                     seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKGDGRLGHDLDPHDRAPKDACGVFGVWAPGEEVSKLTYYGLYA
                     LQHRGQESAGIAASEGSRILVYKDMGLVSQVFDESVLGTLRGHLAIGHCRYSTTGSSVW
                     ENAQPTLSSTEVGGLALAHNGNLINTPELAQRLAPGSTRATTDTEVLTTLLAQDRTRSI
                     EDSAAELLPQVKGAYSLVFMDEKTLYAARDPQGIRPLVLGRLERGWVVASETAALDIVG
                     ATFVREIEPGELLTIDERGVRSRRFALAEPKGCLFEYVYLARPDTTIAGRGVQVTRVEV
                     GRVLAREHPVEADLVIPTPESGTPAAVGYAEESGIPYGQGLVKNSYVGRTFIQPSQTIR
                     QLGIRLKLNPLREVVEGKRLVVVDDSIVRGNTQRAIVKMLREAGAREVHVRISSPPVAW
                     PCFYGIDFATRAELIAGSLTVEEIRASLGADSLGYISLEGLTKATTLPADRLCRACFTG
                     EYPIPIDQDNVGKFVLESKA"
     gene            20342..21367
                     /gene="purM"
                     /locus_tag="MF672_RS07560"
                     /old_locus_tag="MF672_007560"
     CDS             20342..21367
                     /EC_number="6.3.3.1"
                     /GO_function="GO:0004641 -
                     phosphoribosylformylglycinamidine cyclo-ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006189 - 'de novo' IMP biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="purM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012895351.1"
                     /locus_tag="MF672_RS07560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007560"
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="WP_242371936.1"
                     /transl_table=11
                     /translation="MSTYEAAGVDIEAGERAVELMKDKVARSRRPEVVDDASGFAGLFD
                     ASALLRYRRPLLATSTDGVGTKVMIAQRYGKHDTIGIDLVGMVLDDLVVCGAEPLFMTD
                     YIACGKVVPERVAEIVGGVAEGCRLAGAALVGGETAEHPGAMGPDEYDLAGAGTGVVEA
                     DALLGPDRVRAGDVVLGLASSGIHSNGYSLVRHIVREAGLSLDAELPELGRPLGEELLE
                     PTRIYSLDCLELARSVEVHAFAHITGGGVESNLARSLPSGLDAVLDRASWTPPPVFGVL
                     AGHGRVAQQDMDRTFNLGVGMAAVVAADAADAALRLLADRGLPAWVLGEIVPGAGQARY
                     R"
     gene            complement(21416..21955)
                     /locus_tag="MF672_RS07565"
                     /old_locus_tag="MF672_007565"
     CDS             complement(21416..21955)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017594208.1"
                     /locus_tag="MF672_RS07565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MF672_007565"
                     /product="ABATE domain-containing protein"
                     /protein_id="WP_242371933.1"
                     /transl_table=11
                     /translation="MELLIGEPLALDLLNTRTRDLDVLDTPGDFQTWLARQAGRLTAPG
                     GPLTPGGLAAVRRLRAHVATALDAVREGAPPPAAALAAINEAARAAPAYQVLEWRDGGP
                     RLSAARDGDPLAVLLAQLAEAAAGLLADPAVTRVRGCEGPGCVLLFLPAHPRRRWCSPD
                     LCGNRVRVARHYQRHK"
     misc_feature    21988..22008
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.52"
                     /tool="antismash"
     misc_feature    22008..22023
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.48"
                     /tool="antismash"
ORIGIN
        1 ctgttactga tgatttgacc gattgtcggt aaccttggtg agtaaaacga cgcattggag
       61 gcatgggccg cgcgtggata atcggcttgt gccaagcgcc gatcccgccc cttacctgcc
      121 cccggccacg cagcccgtcc gcggagtggt gtgggcgatc cacctggtcc tgcccatgct
      181 gggcctctgg ctgctgctcg ccaacgacaa gatcaacatc ccctggcagc acaacccgag
      241 ccacttctgg tcgatcctcg cggtcgccgg ggtcaacgtg gcgctcggcc tgatgatcag
      301 cgaggcggcg cggcggcgcg gcgacgcccg gctgttcctc gtgtccatgg tcttcctgag
      361 cagcgccggc ttcttcttca tgcacggcct ggccacgccg gggttcatcc tgcgcaccgg
      421 ctcgctcggc ttcgacgccg gccagcaggt cgggctgtcg gtggccgccc tgttcgcctt
      481 cgcctccgcg ctgccgctcg gcgagcgggc cgccgggcgg gtgctggccg cgcagcactt
      541 cgtccgggcg gcgctgctcg gcttcatgct ggtgtggggc ctgacgtcgc tgacgccggg
      601 cctgacgccg ctcagcgagc ccccggccga ggcgccggtg ccctggctcg cctggggctc
      661 gctgcccggg ctgctggcgt acgcggcggc gagcgtgatg atgttcctca tccaccggcg
      721 gcggccctcg gccatgctga tcagcctcat caccgcgtac gcgctgctgg ccgagtccat
      781 ggtcgccggc atgtcccagc acaactggca cctgtcgtgg tgggagtggc acctgctgct
      841 gacgctggcc ttcgtcttcg tggcctacag ctcctacctg cagttccggc gcgagggatc
      901 gagcgccggc ctgttcgact cggtggcgct ctcggccacc gtgcggcgca tcaggcagga
      961 ctacgaccgg gcgctggagg agctggtcga gcacgtacgg cgcggcgagc cgctggccgc
     1021 gacccggctg tcgggcaagt tccggctcaa cgagggccag gccgcggtgc tggaccgggc
     1081 cggccgggcc ctggccgagg agcgtgagct gtcggtgcgg ctggcggcgc tggtcgacgt
     1141 cagcgggcgg accaaggtcg gcctgccgga gaacgagctg ctggcttcgt cgctggagcg
     1201 ggtgcggcag gcgtacgggg acgtcaggat cgcgctggtc gccgacggga ggacccaggt
     1261 gggctcgcgc gagtacgcct tcaccggcga cgagccgatc cggcgcgacc acctgctggc
     1321 cttccccctc acggtcaagg ggaagctggc gggcgtgctg gaggtgccga tcggccgcac
     1381 cagccaggac gaggcgctgg ccgccacgct ggccggccag ctgtcgatct cgctggagaa
     1441 cgcccgcctc taccaggagc tgcacacgct gttccaccag tacatgtcgc cggacgtggc
     1501 gcacgcgctg ctggccgacc ccgcgcaggc ggcgctcggc ggcgagctga gggagctgac
     1561 ggcgttgttc gccgacctca agggcttcac cacgttctcg gagaaggtga cgcccggcga
     1621 gatcgtcgag atgctcaacc gctaccacac cgccgccgtg ccgtgcatcc tcgacaacgg
     1681 cggcacgatc gtgcagttcg tcggcgacgc gctgctcgcg ctgttcaacg cgccggcggc
     1741 gcaggccgac cacgcgcggg ccgcctgccg ggccgcgctc gcgatgcagc aggcggcggc
     1801 cgaggtggcc gaggagatgg cctggaagcg ggtggacgac gtgccgtggc cgacgttccg
     1861 ggtgggcgtc aacaccgggc ccgccctggt cggcaacatc ggcagccctg agctgcgcgg
     1921 cttcaacgcc atgggcgact gcgtgaacgt ggccgcccgg ctggagggcg tcgccgtgcc
     1981 cggcacggtg gtcatcggcg agaccacgct acggcacctg ggcgagggcg cctcggtgcg
     2041 gccgctgggg gacctgagcc tgaagggcaa ggaggaactc gtcacggcct atgttctgac
     2101 ggatttggcg tagtagggcc gggctcgtac cgacataatc gggcgcatgg atccagagcc
     2161 aggcgagttc ctttccatgc tcaccgacga ggaggcgcag gcgctgcggg cggccggccg
     2221 catccggcgg tgggaccgcg gcaccgccgt catgaacgag ggcgacctgg ccgactgggt
     2281 gctcgtgctg ctcgacggcc gggtgaaggt gtcgtcgcac accagcagcg gcaccgaggt
     2341 ggtgctcgcc gtgcgcgggc cgggcgggct gctcggcgac atgtcggcca tcgacggctc
     2401 gccgcgctcg gccaccgtga cggcgctgga gccgatcacc gggatcgtgg tgcgcgactt
     2461 cccggcgttc ctggagaccc atgggcgcat cgcggtgctg ctgatgaagc tcgtcaccgg
     2521 ccggctgcgc gactccgacc ggaagcgcat cgagtacggc gccttcgaca cgaccggccg
     2581 ggtggccacg cgcctgatcg agctggccga gcggtacggc gagaagacca acggcggggt
     2641 gcgggtggcg ctgccgctgt cgcaggacga gctggcgggc tggaccggcg cgtccaggga
     2701 ggcggtcagc aaggcgctgc gcacgctgcg cgaccggggg ctcatcgaga cggggcggcg
     2761 gcgggtggtc atccacgacc tcgacgggct caggaagcgc gccaggtaac ccctgtcaca
     2821 aaacggacgt acgtcgtacg tcatagtggg agcatggtcg cggtcacccc ccatgacgac
     2881 agccggctcc gctacgcctg gaaggtgtgc tccgtcacca gcctggggct cgtcctcatc
     2941 ggcatcgccg gcagcacgct caacgtggcg ctgcccgccg tggtgcggca cttccacgcc
     3001 gacgcgacgg agtccggctg gatcctgctg tcgttcctgc tggtcaacac ggcgagcctg
     3061 gtcttcttcg gccgggtcgc cgacctgctc gggcggcggg aggtctacct ggcggggttc
     3121 gcgctgttca ccgtcgcctc gctgctggcg gggctgtcgc cggacgtgtg gttcctcatc
     3181 gcgatgcgcg tggtgcaggc ggtcggcgcg gcgatgatcc tggccaacgg caccgtgatc
     3241 atcaccgacg cgttcccgcc ggaacggctc agccagggca tgggcgtcta catcggcacg
     3301 ttgtcggtgg cgcagctcgc cgggcccacg gtcggcgggc tcatcgcgga gacggccggc
     3361 tggcagtgga tcttctgggt gaacgtgccg gccgggctga tcgcgctcgc ctggggcgcg
     3421 gcgatcttac ggaaggtgcc cagggggccg cggcagccgg tggacggcct cggcaacgtg
     3481 ctgctgttcg ccgcgctgtc ggcgctgctg ctggcgctgt cggagaccgg ctcgcgcggg
     3541 gtgggcagcc cggtggtgct ggccggggcc ggggtgttcg cggtgctggt gccgctcatc
     3601 gtgctggccg aacggcgggc cgcgaacccc gtgctggacc tgcggctgtt cggcgggcgg
     3661 ctgctcgcct acgcgaacgc ggcctcgttc tgcaacgcgc tcgcccgctc ggcgctgatc
     3721 ctcgtggtgg cgctgtactt ccaggcggcg cgggggctcg acgcgttcgc ggcggggctc
     3781 agcgtgctgc cggtgccggt cgggatcggg ctggcctcgc cgctcgtggg gctgctgggg
     3841 cggcgggtgt cgccgtacgc gctgtcgatc ggcggcgcga cgctgagcgc gctcgggctc
     3901 gggacgctga cgctgacggc cggcccaggg acgccgtact gggtgaccgg gatagggctg
     3961 ttcgtggccg gctgcggcag cgggacgttc ctcaccggca acaccaccca ggtcatgcgg
     4021 gcgctgccga gcggcagcct gggcgtggtc aacggcttcc gcgtcatgat catgaacgtc
     4081 gggatcgtga tcagcgtcgg cctgtcgctg agcgtgctga ccgcctccgt cgggcccgag
     4141 ctgcgcgccc aggtgtacgc cggcacgctc tccaggctct cccccgtggc cgtggggcag
     4201 ctcatggagg gtttccagcg ggcctacggg gtgttgttcg cggtggccgt ggcgggcgcg
     4261 ctgctggccg ccctggcccg cggtcagagc agcgcggaga gcctggactc gacgtcgcgg
     4321 tagcgggaga ccggcaccag gtgcaccccg gcgaacgcgc ccgactcgcg cagcgcgagc
     4381 acctgctcgc aggccgcctc gacgcccgcc atgcggtcgg ccgccacccg gcgcaccagg
     4441 tcgtccggca ggtcgatgtc ggggatggcg gccgccagcg tgcgggcatg gcgctcgctg
     4501 gccagcacca tcactccggc gtagaccggc acgtccgccg ggtgcgcctc gcgccaccgg
     4561 agctgggcct ccaccgagta gctgacctgg aggaacagga agtcggccgc gcgcttccac
     4621 gacggcaggg agcgcagccc ggccgccgcg ccgagccgca ggtccggcga gaacgcacgg
     4681 gcctcgtcga gcatcgagcg caccgtgagg tcgctggtgc ggttgccgct cgtgggcttg
     4741 tcgccgtaga cgaacaggaa ctggtcgacc ccgtaggccg ccgccgtgag caggtcgcgc
     4801 cggaagccga gcaggttgcg gtcgcgggag ttgaggcagg cgatgccgcg cccgcccatg
     4861 gcctcgacct cgtgcgcgac cgcgacgctg gagacggtgg cgcggccgat gtggttgtcg
     4921 gggatgagga acgcgtgcgc gatcttgctc atggtgccga tctggtgcct gacgtgcttc
     4981 agatcgggct tggtcggggg ttcgatctcg cagatcagct cgaaggtcac ggctccgact
     5041 gtatccggcg ggccgccagc gcctcgatgc ccgccaggac gagatcgacg ccgaaggtgt
     5101 cgtacagctc cgggtccatg ccgccggcca gcggcgcggc catctccacg atgaacgggt
     5161 accgctcggg cggcagcgcc tgcagcccgg cgcgcctggc cctgacctcc tgttcgtcgc
     5221 gggagtgccc cggggcgtcg gcgatggcga tggcgctccg cagcaggtac tggctgatga
     5281 ggcagctctc gtcggcgctg aagccggccg tgcggccgag gccgagcgcc cggttccaga
     5341 cggccaggta gttggggacg gccacctggc cgacgcgctc gaacacgtcg cgggcgcacc
     5401 ggtgcgcgcg cagcgtgcgg atcaggccca ccgtgaggtc acggagctgc tcctgccacg
     5461 ggcgctcgtc ggcgggctgc ggcgcgaagc cggcgatcag gtggtcggcc atgccggcga
     5521 ggagctggtc cttgttcttg aagtgccagt agagggccat cggggtcacg cccaactcgg
     5581 cggcgaggcg cctgatcgtc acggcgtcga gaccttcggc gtcgccgatc tccagggcgc
     5641 gctccgcgat cgcctgagcg gtcagttttc ccatcacggt tgacaactat acgccgtaca
     5701 cgttgaactg tacgacgtac aagtacggcg tataggaagg cgtcgccatg cggtggtggg
     5761 cgttggtcgc ggtgactctg ggcaccttca tgacctatct ggacaacaac gtgggcaacg
     5821 tggcgttgcc caccatccag cgggagctgg ggctcacggt ctccgggctg gaatggatcg
     5881 tgagctcgta catcctggtc ttcgccgggc tcatgctggc cggcgggcgg ctcgcggacg
     5941 tgttcggggc gcgcggggtg ttcctcgccg gcctcggcgt cttcaccgcc gcgtcgctga
     6001 ccgccggcct cgccaccagc ggcggcctgc tcatcgcggc gcggggcgcg cagggcgtcg
     6061 gggcggcgct gctcacgccg accgcgctgg cgctgatcgg gcagatcttc cccgaccccg
     6121 ccgagcgcga ccggcgcgct gtccatggcg ctcgggccgg tggcgggcgg cttcatcagc
     6181 gagcacctgc actggggctg gatctacctg gtcaacgtgc cgatcggggc ggccacggcc
     6241 gggctcgcgc tgtgggcggt caagccctcc gcgcggggcc ggcggcacag cctggacctg
     6301 cccgggctgg tcacctcggc gctggcgctg gtggcgctca cgtacgggct catcgagggc
     6361 gacggggccg ggtggacgtc gccggagatc ctggccgcgt tcggggtcgc cctggcggcg
     6421 gccgtggcgt tcgtggtgat cgagtcgcgg gccgccgagc cgatgctggt gatggcgctg
     6481 ttccggtcgc gggtgttcac cggcggactg ctcaccagcg gcatctggtc gttcggggtg
     6541 ttcgggatct acttcttcag cgccctgtgg ctgcagaacg tgctcggctt ctcccccacc
     6601 gaggcgggcg cctcgttcgt gccgatggcc ctggtcacgg ccgtcgtggc gctgctgtcg
     6661 cagcgggtga gccggctgtt cggcatcggc ccgaccgtcg cgaccggcct ggcgctcatg
     6721 ggcaccgccg tctacctgct ctcccgggtc ggcggcgggg ccggctacgg cgacgtcggc
     6781 ccgtggttca tcctgtacgg cgtcggcgcc ggcctgatgg tgccgctgac cgccgccgtc
     6841 ctcgccggcc tgccggccgg gcgctcgggg gtggccgccg gcatgctgaa cgtctcccgc
     6901 gaggtcttcg gcctgctcgg cgtcaccgtc ctcggggcga tcctgagcgc ccggcagagc
     6961 gcgagcgggc tgcccgcgct gcccgccttc ctggacgggt acgcgttcac gctggtgatc
     7021 gcggcggccg tgatgctggc cgccatcccg atcgccctgt gggccctccg ggcccgccgc
     7081 ggccccgtcc cggccgagga cccgacggcc cccgagccgg ccgccgtcgg aagcccgacc
     7141 tctcaggcga gcgggaggac cgcccagacc acccgctcgc ggcgctcgtt gcggaagtga
     7201 ccccacaggc caccggtcag caggtccacc aggacgaggc cccgcagccg ctcgacaccc
     7261 gggtcagggt cggggtccgg cgaggggtcg ttgtcgggca ggcccatggc gggctcgccc
     7321 ggcgaccgtc ccgggtcggt gaccagcagc tcgcagcgac gcgactcggt ggtcagcttg
     7381 aggcggacgt acccggcgtc cggcatcgga ccgaggccgt ggcggacggc gttggtgacc
     7441 aattcgctgg tgaccgtctc caggtcgtgc gcccgcgccc cgatccagcg gcagacggtg
     7501 tcccgggcca tcgaggggaa gagcagcggg tccgcgatcc ccgccaggaa ggtgtgctcc
     7561 atgggcatac ggctttctcg tgggcggtag gccaacaaga gcatgaccgt ctggctatgg
     7621 aagcgccgca ggttgcgggc gtaccgttcc gtaccgttcg taggcgactg cggtgggtga
     7681 cggagggcgg catggcggag aacgggcagg accccagcct caaagcctgg caggagtacg
     7741 ccgagcgcct ccaccggtac cggtccgacc aggggttgag ccagcaacgg ctggccgagc
     7801 gcattcccta cagcgaagcg gcggtagggc atgtggaacg gctcatccgc aagccgtccc
     7861 atgggctcac caaggagctg gagagggtgt tcgggctcca gggcgagctg atggagctgc
     7921 tgccggagat ccacggcgtg gggccgaagt ggttccggga gtggcctcgg gtggagaagc
     7981 tggcgcacac gatcaggacg tccgagccga tgctcatccc cggcctgctc cagacggaga
     8041 ggtacgcgag tcacacgttc ctcggagagc cgggagcatc cgtggaagag atcgagacgg
     8101 cggtcggctt ccggcttcgc cgtcagcgga tcttcgcacg ggccaggcct cccgtgtact
     8161 cggcgctgat cgacgagagc gtgctgcggc gtcctgtggg cgggggcgcg gtgatgcgcg
     8221 agcagttgca gaagctgacc gatgtgctga acccgcccta tgtcacggtg cggatcattc
     8281 ctctgtccgc ggggctcacg gccggctgcc tcggagcctt cgagatcgcc acgctcctcg
     8341 acggcgggcc gacccacgcg tacgtggagt ccgccgaaga aggccgcgtc accagtcgcg
     8401 ccaagacggt gcaggcgctt acggttcgat gggaggcgct gtccggcatg gcgcatcccg
     8461 tggaccggag tcgcgcgatc atccgcgagg tgatggagag ctatgagcag tgagcggggc
     8521 ctccgtacag gcgtgtggac caaggccagg gcgtcgggcg ggaacggcgg gagctgtgtc
     8581 gaggtgatgc ggctggcgga tggcggggtg ctggtcaggg acagcaagga cggcggccag
     8641 gggcccgagc tgagcttcac ccgggccgaa tggctggcct tcctggacgg ggccgggaag
     8701 ggcgagttcg acctgtccta gggcctgtac ggagttgaga tcagagggat tacctgcggt
     8761 atggccggcg gtcctggtag gccatcgggc atggcgcgtg gagacctcac cgacgaggaa
     8821 tggtccttga tcgagcctca cttaccgctg ggtgagcggg gtccgatccc ggatctgcga
     8881 cggctgttca atgcggtgat gtggcggttt cgtaccggca gcccgtggcg cgacctgccg
     8941 accgagtacg gaccttggtc caccgcctac gaccggttcc gctcctgggc gctgaacggc
     9001 gtgttcgagc aactgatgca ggcgatgatc gccgaggccg cggcccgtgg gcaggccgac
     9061 ctcgacctgg tcagcgtgga ttccaccacc gcccgcgctc accatcatgc cgccgggatg
     9121 gtcttggacg gcgagctgag cgcagcgctg gaagaagccg ccgaacggga aaaggggcta
     9181 cgccaaaggg gcaaaacgcc cgcaacgaca gcgacgacga agggtgcgac ggggacgggg
     9241 acggacgaag gcggctgcga cgccgacacc ggttccggct gaaggcggcc atgctgggcc
     9301 gctcgcgagg cgggctgacc agcaaggtgc atctggccgc cgaccggcga tgccgtccgt
     9361 tgtccttcgt cctgactgcc ggccaggcag gcgatagccc gcagttccgc gccgtgctgg
     9421 agcgcatcaa gatcggcctg ccgatcggcc gtccgcgcac tcggccgggc gcggtggccg
     9481 cggacaaggc ctactcctcc cgcggcaacc gcgcctacct gcgtcggcgt cggatcaaag
     9541 cgatcattcc ggagaagatc gaccaggcgg ccaaccgcaa gaagcgcggc tcccgtggcg
     9601 gccggccggt cacccatgat cccgatctct acaagcagcg caacacggcc gaacgctgca
     9661 tcaaccggat gaaggagtgg cgtgggctgg ccttccggtt cgacaagacg cccgccagct
     9721 atctggccgg cctgcacctg cgaggagccg tcttatggat tcgaagcctg cgaccagcct
     9781 agagatccga actccgtaca cgccctagcg cggctcggac ggtccgggag gatcgcccga
     9841 gccgcttcgg agcggggcgg tcagtcacac agcagaaggc tgagcccgct gtcggccgcg
     9901 cagccggtga tgctcaggtg cgattgagcg gcggcctggt caccgccctt ggggtcgcgc
     9961 tccggtggca gggcctgcag gtcgagaagg gtcatgggat tcacctcctt tcgtccagga
    10021 agggcaggga ggcggggcgg cggtgctggg cggcggcgag ggcgagcagg acgccggcgg
    10081 cgccggtcgc gaggtcggcc gacaggcgga gcagctgctc gccggggaag gccaggccgc
    10141 cccggtgggg cagggcgtgc caggcgagcc ggcgcgcctg ctcggggccg tgctccgggt
    10201 cgtccgccag cgccaggacg gctccggcgc gcccgctgaa caggccgggc tggacgaaga
    10261 agccgctgcg ggccacccgc cggatcccgg ccagcgcccg cgcgaaccgc gcgtcgtggc
    10321 ggtgccgcag gtagcggcgc agcaccaggc cgatgccgat gctgccgccc gccaggtacg
    10381 gcatcagccg ccatccttcg tcgacctgga gaaggccgtc gtcatcggtg acgcagcggc
    10441 cgaggtcgtg gcggagggcg gtggccgccc ggtccaggta cgcggggtcg ccgcggtcct
    10501 cgtacagggc gaggaacagc agggcgggcc cggaggcgcc gtgcatgagg cccgcctgcg
    10561 cgggcgggtc gtcgccgatc cggccggcca gcaggtgcgc ggcctcccgc aggtcggggc
    10621 gggcggtcag gcgggcgaag tgcagcaggt tgaggccgat gccggccagg ccgccgtaca
    10681 ggtcgtggcc gcagtccgtc aggtcgtggc gccgggcggc ggccagcacg tccagggcct
    10741 cggggaggcg gcccaggcag gccagcgcgt acgcgatgcc gtgcagcccg tcgtagaagc
    10801 cgggccggac gtcgcggccg gtcaggacgc ggtcgagcag ccaccgctcg tggccgggga
    10861 accggcccgc gccggaggcg tgcagggcgt agaggacgcc cgccgccccg tgcgccaggt
    10921 tgagcccgcc gcccgggccg aactgggcga tgtcgccggg gaagagccgg tcggcgcggc
    10981 cgggggtggc ggtggcgagg atcgcgcggg tgatcgcgtc ccggcccggc ccgtccggtg
    11041 cgaggcgcgg gcgggacggc ggccggtcgg gggcgatgac cgcgacggcc tcccgcagcc
    11101 actcctcggg cacggggaag tgctcggcga cgaggtccgc gaggtgggcg gccttgccgc
    11161 ggtcgagctg cagcagcatg ggcatcggca ggaacagcgc cagccgcagc acggccagcg
    11221 cgtgccggtc caggtcggcg ccggcgcggc cgggcggcgc gaggaagccg ggcgcggcca
    11281 ccgcggggcg gcgccgctcc gcgaccggga aggccgcctc gtagtcgatg agcgtcaccg
    11341 acccgtccgg gcggctcagg acgttgccca ggtgcaggtc gccgtggacg tagccgcggc
    11401 ggtggagctc ggcgaccgcc tgctcgacga ggccgtgggt gcggagggcc cagcgggtga
    11461 agccggccac gtcgcgctcg cggccgacct cggcggtcag cgggtgccgc ctggccaggg
    11521 cggtgctgag ggtgatgccc gggacgagct ccatggccag gaactcgtgg tcgccgaggg
    11581 tgacgtagcc gtccagcgcg ggcacggcgg ggagcccgga cagccgctcc agcaggttcc
    11641 gctcgtggcg cagccgggtg accgcgtcgg agccgtcggc ggagaagccg gcgtgcgggc
    11701 gggcctcctt cagcaccacc ggctcgccgt cgtccctgcg gcgggcgcgg tagaggccgc
    11761 cgccgttgga atggtgcagg gcggcctcga tctcgtacgg cagcgcgccg accgtcacgg
    11821 cctcgcgggc cgccaggtgg ggcgcgagga agggcggcag gtcgacccag ggcggcagcg
    11881 cgaacaccgg gccgcgcgga tcgggcacca gggcgccggc ggggtcctcg atcgcgggca
    11941 cccgctcgcc gtccgcggac cggcaccagc gggggacgaa ggcgccgtag cggacgtaca
    12001 gcgggccggc cgcgatgcgc aggtcgctca ggatgtacgg gcccggctcc ccctccagca
    12061 ggccgcccag ctcggcgcac acgcgctcca gctcggcctc gtcgcgcggg tagagggtca
    12121 ggagcttgcc gctgcccgcg cgaggggcgt acttggcgtt gcgggcgagc accgcgcgcg
    12181 ggccgcgcag gaacttgaag gcgagcccgc gcggcaggca gtaggcgcgc accgcggcga
    12241 tgagccgttc ggcgttgtcg gggcggccgg agacgtggat cttccagccc tgggcgggca
    12301 ggcccgggcc gggcggcagg cagctgcgcc actcgtggtg gtcgtggcgc agccagccgg
    12361 gcggcaaggg ggcgcagggg aagtcgtccg ccgcgggagg gacgtcgtag aagagcgggt
    12421 cggcttggca gaagaggtgg taatccctgt tcactggtca cctcgtcagg gctcacccgt
    12481 tacggtcccc cgaaaaggaa ctacctaaag tgaccgcgag gtgacatcaa gcgaccccca
    12541 cggtcgccgg gtcgtcgaac tgggtgcggt agagctcctc gtagcggccg ccggcggcca
    12601 gcagctcggc gtgggtgccg cgctcgacga tccggccgtc ctcgacgacc aggatgaggt
    12661 cggcggcgcg gatcgtggac aggcggtgcg cgatgaccac ggcggtgcgg ccggccaggg
    12721 cctcgccgag ggcggcctgg acggcggcct ccgaggtggc gtcgagcgcc gcggtggcct
    12781 cgtccaggat caccacccgg ggctgggcca gcagcaggcg ggcgatcgtc aggcgctggc
    12841 gctcgccgcc ggacaggcgg tagccgcgct cgcccaccac cgtgtcgagg ccgtcgggca
    12901 gcgaggcgat gagggcggcc aggcgggcgc gggtcagggc gtcccagagg tcgtcctcgg
    12961 tggcctcggg gcgggccagc agcaggttgg ccctgatcgt gtcgtggaac aggtggccgt
    13021 cctgggtgac caggccgagc gtgtcgcgga tggcgtcgaa ggacagctcg cgcacgtcca
    13081 cgccgccgag ccggaccgcg cccgcgtcca cgtcgtacag gcggggcagg agctgggcga
    13141 tggtggactt gccggcgccc gacgagccga ccagggcgac catctgtcct ggttcggcgc
    13201 ggaacgagat gccgtgcagc acctcctcgc cgccgcgcga gtcgagcacg gcgacctcct
    13261 ccagcgaggc cagcgagacc ttgtcggccg aggggtaggc gaagcgcacg tcgtcgaact
    13321 cgaccgcgac cgggccgtcg ggcacccggc gcgcgcccgg ccgctcctcg atgagcggct
    13381 tgaggtccag cacctcgaag acgcgctcga agctgacgac cgcggccatg acgtccatgc
    13441 gggccgaggc gagggcggtg agcggggcgt acaggcgggt gaggagcatg gccatcgaga
    13501 cgaccgcgcc gggctggagc tgctcgcgca gggcgtagaa gccgccgagg ccgtacacca
    13561 gggccagggc gagcgccgag accagggtca gcgcggtgac gaaggccgac tgggtcatgg
    13621 ccgagcgcac gccgatgtcg cgcacccggc gggccctggc ggcgaactcg gcggactcgc
    13681 gggccggccg gccgaacagc ttgaccagcg tcgcgccggg cgcggagaag cgctcggtca
    13741 tctgggtgcc catggcggcg ttgtggtcgg ccgcctcgcg gcgcagccgg gcgatgcggg
    13801 cgcccatgcg gcgggccggg agcacgaaga cgggcaggag cagcagcgcg agcagggtga
    13861 tctgccagga gatgccgacc atcgcggtga gcgtgagcgc gagcgtcacg aggttgccga
    13921 cgacgccgga cagcgtgtcg gtgaaggcgc gctgcgcgcc gatcacgtcg ttgttgagcc
    13981 ggctgaccag ggcgccggtg cgggtcctgg tgaagaaggc gaccggcatg cgctggacgt
    14041 ggtcgaagac ggcggtgcgg aggttcagga tcaggtcctc gccgatgccg gccgacaacc
    14101 agcggttgag cagcccgagg cccgcctcgg ccacggcgat cgcggcgatg gcgagcgcca
    14161 ccgtgaccac cgcgctcagc ggctcggcgt tgaagatggc gtccaccacc cgtcccgcga
    14221 gcagcggcga ggccaccgcg aggcccgcga gcaccacgct gagcagcacg aacagggcga
    14281 gcttgcggcg gtgcggccgg gcgaagccgc cgatgcgccg gagcgtcgcc cgcgacaggg
    14341 gacggcgctc cggccggttg ttcatcgagt acagctggtg ccaggcggtc atctccatgc
    14401 tcatggcatg gaacactagt tcctcaagtt aagttgaggt caactgccga tcttcttgtt
    14461 cttcgcgtgc cagaccacgg ccacggcggg gcgcggctgg tcgccgtcgg gccagcggct
    14521 cgccggctgg tccggggagg cgccgtcgat ctcgcccggg tgctgcaccg ccacgaacac
    14581 gctgcgctgg tcctcgctca ccagcgggcc gcaggtctcc gcgccgaccg ggacggtgag
    14641 gaactggcgc aggtggccgc gctccttgcc gcgcaccggc atgacgaaca ggccgtcgtt
    14701 ggagccgagg gcgttgccgt cggtggagat ccacaggttg ccgtcgcggt cgaacgtgac
    14761 gttgtccggg cacgagatcg gcgagacctt gctcttgtcg tagccggcga agtacgtcgc
    14821 ggggtcggcc gggtcgccgc agaccagcgg cagcgaccag gcgaaggtgc gctggcccgc
    14881 gtcgttgccc ttctcgacga gctcgagcac gtggccgtgc ttgttggacg ggcgcgggtt
    14941 ggcctcgtcc acctgggcgg cggtgcggtt ggtgttgttg gtcagggcca cgtagacgcc
    15001 gccggtgacc gggttgcgct ccatgtcctc gggacggtcc atcttggtgg cgccgccctt
    15061 cacccggtcg gcggcgaccc gggtgtagac caggacctcc gcggcggtca tgccctccac
    15121 gtacgacttg tcgcccgaca ccagcggcag ccactcgccg gagccgtcga acgcgccgtc
    15181 cgaaggcagc ttgccggtgc cgtcgatctc ggcggccggg ctgtcgccgg tgaacttggc
    15241 cacgtacagg gtgccctcgt ccagcagcgt ccggttgtgc cggtcgaagc ccgggatgta
    15301 gcggttcttg gagacgaact tgtagatgta ctcgaagcgc gagtcgtcgc ccatgtagac
    15361 gaccaggtgg ttgtcgcgcg acagggtggt gttggcggcc tcgtgcttga gccggccgag
    15421 cgcggtgcgc ttgatcggcg tggagtccgg gtcgaacggg tcgatctcca cgatccaccc
    15481 gaaccggttg gcctcgttcg ggtgcttggc caggtcgaag cgctcctcga cgcggtcgaa
    15541 gcggcggttg ccggccgggg tgccggtggt gatcgtgtag cgggcaatgt acggcttctg
    15601 cgcctcgggg accttgtcgc cgttgacgaa gtactggtcg atgttctcct cggcggtcag
    15661 gaccgtgccc cacggggtgg tgccgccgga gcagttgttg agcatgccga ccgggttgcg
    15721 gccctcgggg tcggcggcgg tcttgagcag gtcgctgccc gccgccgggc cggtgaaccg
    15781 catcggggtc tgggcggtga tgcgccggtt gtagcggcgg cggcccttgg tgaccagctt
    15841 ccactggccg gtgttgccgg cccgctcgat ctcgacgacc gagccgccgt gcgcggccag
    15901 cgcgatcttg atctgctcct cggtggccgt ggcgccgccc gtgtagccgc ggaacatcag
    15961 gctctcgtcg gtgtactcgt ggttgaccca cagcagcgcg cggtcgcggc ccagcggaag
    16021 cagcgtcacg tagtcacagt tgtagccgaa ctgcttggcc tgggcctcgg ccgtctggtt
    16081 gtcgaagtcg aaggccgggg cgtcgggcag caccgggtcg ccccagcgcg ccaccacgga
    16141 ggagctgtag ccgtcgggga tgcgcagcgc gtcctcggtg ctgggcgcga cgggcgtgaa
    16201 gttcaggcca ccgttgccgc cgccggtcca gcccttggcg gcggcggcct ccggctcgtc
    16261 ggcgagcgcc ggcgcggccc cggcgacgcc cacgccggcc accagcgcgc cgagggcgcc
    16321 ggcccgcagc acgccgcggc gcgacagcgc ctccttcacc acgtcgccga agtaggcgtt
    16381 gtccgtcgtg ttggccacgt cgtgcgcgca cgcgttccca cagcggaact ggcaggtcaa
    16441 cgcggaacgg ccacctttgt gcggagtgga aagcagcggc agcggccgcc gcccgccccc
    16501 gatgaggttt gccacaggtc ctccatatat gcgcggttgt accgccggga ggttacggtc
    16561 ggcggcgaaa ccgcaggtga acgaagacct ccgtctcgat gaacgcttcc cgcgagacaa
    16621 tggcggggtg ccaccacgca agatggaccc ggaaaagctg agagccgccc tcgacgccca
    16681 gctcgtcgcc ctggacgagc cgccgtacga cgggccggcc gccgcgctgc ccggcgcgct
    16741 ggtcgcggcc gtgctggccg cctacgaccg cggcctcgcc cccgagcgcg acgcggcccg
    16801 ccaggccgtg accgcgcacc tgctcgaccg cctggccgcc gccgcccggg gcgcaccgtg
    16861 gaggtgcgcg tgccgccgta cgcggccgtg caggcgatcc ccggcccgcg ccacacccgc
    16921 ggcaccccgc ccaacgtcgt ggagaccgac gggcgcacct ggatcgagct ggccgtcggg
    16981 cggctcacct gggaggaggc ggtggccaag ggagcggtct ccgccagcgg ctcacgcgcc
    17041 gatctggcag agcacctgcc gctgcgcgac tagccgcggc ggccgccgct catccagggg
    17101 aagcgctcct cgaagcagcg gtcggcggcc gggcccgaca ggtgggcgca gtcctgcacc
    17161 acgttccaga accagatcgc cacgatcgcg aacaggatca gcgacaggac gctgatcacg
    17221 atgccggcca gggcgcggcc cttgcccgcc ttcctggcga gcgcgacgca gccgaagacg
    17281 atcgacagga tcgcggtgat caggccggtg aagcagacga acacgaggaa cgggctggcc
    17341 acgcccagca ccagcgacgc cgtggccagg ccgttgccgg tcctgtcctg gggcgggcgg
    17401 tcgccgtact ggtagggcgg ggcccccggg tagccgtacg ggggcgaggg gtagccgggc
    17461 gggccgccgt acgggctgga cgggctggtg ccgggcaccg cctcctggtg cggcgggacg
    17521 ccgccccctt gcgggccgcc ctgggggcgg ccgggagtgc ggtcgggcgt cgtgtacccg
    17581 ccgccgtacg ggtgctcggg gcgcggctcc tcgtagcggg agggcgcggg cggccgggcc
    17641 gggggctgct cgtcctgcgg aggagcgctc tcccagccgg ggtaggcggg cgtcgcgccc
    17701 gggatcggga acgcctgggt cgcctccgcg tcctcgcccg ccgccggggc cggggtctcg
    17761 ggcgcggccg gcagatcggg atgcccgggc cgttcacccg ggcgcggctc gtgcggcggg
    17821 tgggggcccg gctcggggcc cggctcgggg cccggctcgc ggggcggctc gtggggcggc
    17881 tcgcggggcg gttcatgggg cggcgggacg acgggcggcg cgggcgcgat cggctcctcg
    17941 ccctcgcgcg gcgtcgcggg aacgcccggt tcctcccctt cgcgtgggtc ctgccccggg
    18001 cggggctcgt tcggatcccc aggtgtggtc acgtctgcgt ctcccgacgg gtctgcatgc
    18061 cggatacttc accctttcgc ggaggccgtc cgctaaacca cgcgacacgg taagagggcg
    18121 ctcatccttg ggtcaccatg cgccaaagcg gcaggcggcg ggcaagatgg ggacatgctg
    18181 gacgagtccc cgtaccggcc cgccgagctg cgggaacggc tgcggcacgt ctactggctc
    18241 ggcggcggca gcggcgcggg caagtcgacg atcgcccgcc gcctcgcggc ccggcacggc
    18301 ctgaccgtgt acgcgaccga cgacgtcatg ccggaccacg cccgccgcct cacccccgag
    18361 gacgcccccc agctcagccg cttcaaggac atggacatgg acgagcgctg gctgaaccgc
    18421 tcgccgcgcg ccatgctgga caccttccac tggtaccggg gcgagggctt cgccctgatc
    18481 gtttcggacc tgctgcggct gcccccgggc cggggcgtgc tcgccgaggg cttccggctg
    18541 ctgccgcacc tggtccggcc gctgctcgcg gacccggccc gcgccgtgtg gctgctgccg
    18601 acgcccgcgt tccggcgggc cgcgttcgag cgccggggct gggacatccc gcgcaggacc
    18661 agcgacccgc cgcgcgcccg cgacaacctc ctggaacgcg accgcctgtt caccgaccgg
    18721 ctcgccgccg agacccgccg cctcgggctg cccgccgtcg gggtggacgc cacgctgggc
    18781 gaggacgagc tcacggacca cgtggccggc ctcatggggc tccggccggc gtgcgggcag
    18841 gtcaccgccc gcgacgtcag cccgccccgg ggtgcgagca cggaagcggc cgacctagac
    18901 tgaagcacgt gctgaagggc gacggccggc tcggccatga cctggacccc cacgaccgcg
    18961 cacctaaaga cgcctgtggc gtcttcggcg tctgggcgcc aggcgaggaa gtttccaaac
    19021 tcacctacta cgggctgtac gcgttgcagc accgcgggca ggagtccgcg ggcatcgcgg
    19081 ccagcgaggg cagccgcatc ctcgtctaca aggacatggg tctggtctcc caggtcttcg
    19141 acgagtccgt gctgggcacc ctgaggggcc acctggcgat cggccactgc cgctactcca
    19201 ccaccggctc cagcgtgtgg gagaacgcgc agccgacgct cagctccacc gaggtcggcg
    19261 ggctcgcgct cgcgcacaac ggcaacctga tcaacacccc cgagctggcc cagcgcctcg
    19321 ctccgggctc caccagggcc accaccgaca ccgaggtcct gaccacgctg ctcgcgcagg
    19381 accgcacccg ctccatcgag gactccgccg ccgagctgct gccgcaggtc aagggcgcgt
    19441 actcgctggt gttcatggac gagaagacgc tgtacgcggc ccgcgacccg cagggcatcc
    19501 gcccgctggt gctcggccgc ctggagcgcg gctgggtggt ggcctccgag acggcggcgc
    19561 tcgacatcgt gggcgccacg ttcgtccgcg agatcgagcc gggcgagctg ctcaccatcg
    19621 acgagcgcgg cgtgcgctcg cgccgcttcg cgctggccga gcccaagggc tgcctgttcg
    19681 agtacgtcta cctggcccgc cccgacacca cgatcgccgg gcgcggcgtg caggtcaccc
    19741 gggtcgaggt gggccgcgtg ctggcccgcg agcacccggt cgaggccgac ctcgtcatcc
    19801 ccacgcccga gtccggcacc ccggccgccg tcggctacgc cgaggagagc ggcatcccgt
    19861 acgggcaggg cctggtcaag aactcctacg tgggccgcac cttcatccag ccgtcgcaga
    19921 ccatccggca gctcggcatc aggctgaagc tcaacccgct gcgcgaggtc gtcgagggca
    19981 agcgcctggt cgtcgtggac gactcgatcg tgcgcggcaa cacccagcgg gcgatcgtca
    20041 agatgctccg cgaggcgggg gcgcgcgagg tgcacgtgcg catctcctcg ccgccggtgg
    20101 cctggccgtg cttctacggc atcgacttcg cgacgcgggc cgagctgatc gcgggctcgc
    20161 tgacggtgga ggagatccgg gcctcgctcg gcgccgactc cctcggctac atctcgctgg
    20221 agggcctgac gaaggccacc acgctgccgg ccgaccggct gtgccgggcc tgcttcaccg
    20281 gcgagtaccc gatcccgatc gaccaggaca acgtcggcaa gttcgtgttg gagagcaagg
    20341 cgtgagtacg tacgaggccg ccggggtcga catcgaggcc ggcgagcggg ccgtcgagct
    20401 gatgaaggac aaggtggccc gttcgcgccg gcccgaggtg gtcgacgacg ccagcggctt
    20461 cgccgggctg ttcgacgcct ccgccctgct gcgctaccgc cggccgctgc tggccacctc
    20521 gaccgacggc gtcggcacca aggtcatgat cgcgcagcgc tacggcaagc acgacacgat
    20581 cggcatcgac ctggtcggca tggtcctcga cgacctcgtg gtgtgcgggg ccgagccgct
    20641 gttcatgacc gactacatcg cctgcggcaa ggtggtgccc gagcgcgtcg ccgagatcgt
    20701 gggcggcgtc gccgagggct gccgcctggc cggggccgcg ctggtgggcg gcgagacggc
    20761 cgagcacccg ggcgcgatgg gccccgacga gtacgacctg gccggcgccg gcacgggcgt
    20821 ggtggaggcc gacgcgctgc tcggccccga ccgcgtcagg gcgggcgacg tcgtgctggg
    20881 cctcgcctcc tccggcatcc actccaacgg ctactcgctg gtccgccaca tcgtgcgcga
    20941 ggccggcctg tcgctcgacg cggagctgcc cgagctgggc cggccgctcg gcgaggagct
    21001 gctggagccg acccgcatct actcgctcga ctgcctggag ctggcgcgtt cggtggaggt
    21061 gcacgccttc gcgcacatca ccgggggcgg cgtggagtcc aacctggccc gttcgctgcc
    21121 gtccgggctg gacgccgtgc tcgaccgcgc gtcctggacc ccgccgccgg tcttcggcgt
    21181 gctggccggg cacgggcggg tggcccagca ggacatggac cgcacgttca acctgggggt
    21241 gggcatggcg gccgtggtcg ccgccgacgc cgccgacgcc gccctccgcc tcctcgcgga
    21301 ccgggggctg ccggcgtggg tgctgggcga gatcgtcccg ggggccggcc aggcccgtta
    21361 ccgctgacca tcggcgcgcg aacggggccg ggcggcgcgc ccagccccgt tcgcgtcatt
    21421 tgtgccgctg atagtggcgg gccacccgga cgcggttgcc gcacaggtcg ggtgagcacc
    21481 agcggcggcg cgggtgggcg ggcaggaaga gcaggacgca gccggggccc tcgcagccgc
    21541 gcacccgggt gacggccggg tcggcgagca ggccggcggc ggcctcggcg agctgggcga
    21601 gcagcacggc cagggggtcg ccgtcgcggg ccgccgacag gcgcggcccg ccgtcccgcc
    21661 actccagcac ctggtacgcc ggcgcggccc gggcggcctc gttgatcgcg gccagggcgg
    21721 cggcgggcgg cggggcgccc tcgcggacgg cgtccagggc cgtcgccacg tgcgcgcgca
    21781 gccggcggac ggccgccagg ccgccgggcg tgagcgggcc gccgggcgcg gtgagccgcc
    21841 cggcctggcg ggcgagccag gtctggaagt cgccgggcgt gtcgagcacg tcgaggtcgc
    21901 gggtgcgggt gttgagcagg tccagcgcca gcggctcgcc gatcagcagc tccatggcac
    21961 ctaatggtac atcccgggat tgacccatta gactcgggct cgctataact aatgcgtctt
    22021 cgactgaaag aggcattagt gatggtcatc ccagaggtgc ggcacggttt cgtggacgtg
    22081 gcgggcgcgc aggtcttcta ccgcgaggca ggcccgcgcg acggcctgcc ggtgctcctg
    22141 ctgcacggct tcccgtccgc ctcccaccag taccggcggc tcatggacgc cctgggcggc
    22201 ggccggttcc ggctgatcgc ccccgactac cccgggttcg ggcacacccg ggcccctgcg
    22261 ggcttcacgt actccttcga ccggctggcc gacgtcgtgg agggcttcgt ccaggcgctc
    22321 ggcctggagc gcttcgcctg gtacgccttc gacttcggcg gcccggtcgg cttccgcgtg
    22381 gcgcagcggc acccggagtg gatcgccgcg ctcgtcgtgc agaacgccaa cgcctacgag
    22441 gagggcctgt cgga
//
