LOCUS       NZ_CP023711            27353 bp    DNA     circular CON 06-APR-2024
DEFINITION  Paenibacillus polymyxa strain C12 chromosome, complete genome.
ACCESSION   NZ_CP023711
VERSION     NZ_CP023711.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5793823)
  AUTHORS   Sun,D., Qiu,J. and Shen,M.
  TITLE     De Novo Assembly of the Paenibacillus polymexa Strain C12 Genome
            Using PacBio Single-Molecule Sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5793823)
  AUTHORS   Sun,D., Qiu,J. and Shen,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2017) College of Biotechnology and Bioengineering,
            Zhejiang University of Technology, Chaowang Road, Hangzhou 310000,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 105.2x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022649565.1-RS_2024_04_06
            Annotation Date                   :: 04/06/2024 06:53:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,129
            CDSs (total)                      :: 4,973
            Genes (coding)                    :: 4,899
            CDSs (with protein)               :: 4,899
            Genes (RNA)                       :: 156
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 110
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 74
            CDSs (without protein)            :: 74
            Pseudo Genes (ambiguous residues) :: 0 of 74
            Pseudo Genes (frameshifted)       :: 26 of 74
            Pseudo Genes (incomplete)         :: 42 of 74
            Pseudo Genes (internal stop)      :: 21 of 74
            Pseudo Genes (multiple problems)  :: 13 of 74
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:37:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4380318
            Orig. end                         :: 4407671
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023711.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27353
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="13"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..27353
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-i"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..24366
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24366
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14366](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14366
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(590..603)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.15"
                     /tool="antismash"
     gene            671..1435
                     /gene="aroD"
                     /locus_tag="CPY53_RS19240"
                     /old_locus_tag="CPY53_19260"
     CDS             671..1435
                     /EC_number="4.2.1.10"
                     /GO_function="GO:0003855 - 3-dehydroquinate dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426256.1"
                     /locus_tag="CPY53_RS19240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19260"
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="WP_040102062.1"
                     /transl_table=11
                     /translation="MGKIVKINDVRIGEGAPKICVPMVGETLEQLKEEAAHLRTLDLDI
                     VEWRVDFFEHVEDLEKVKAALHEIRSILANIPLVFTFRSAREGGEKEISAASYVELNRT
                     VAETGQVDIIDVELFNEEADVKTLVEAAHKHNVYVIISNHDFQKTPPKEEIVSRLRKAQ
                     ELGGDLPKIAVMPTNTADVLTLLDATRTMAEEYADRPIITMSMAGKGVVSRLTGELFGS
                     ALTFGAAKKASAPGQIPVTELREILQVLHSHS"
     gene            complement(1536..2108)
                     /locus_tag="CPY53_RS19245"
                     /old_locus_tag="CPY53_19265"
     CDS             complement(1536..2108)
                     /EC_number="2.7.1.71"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004765 - shikimate kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819867.1"
                     /locus_tag="CPY53_RS19245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19265"
                     /product="shikimate kinase"
                     /protein_id="WP_016819867.1"
                     /transl_table=11
                     /translation="MQNNSEIPLKEQNIVLIGFMGVGKTTIGSHLARKLYRDFVDIDQE
                     IEQEYNMPTTEIFKTYGEKRFREIEKEHILKLCSNTRLKIISVGGGAFLQEEVKQACLA
                     SSIVFFLDLNWDSWKDRLKMLIDTRPNLQNKTLEEIEDLFRSRQDIYAVNHSKIDTDQL
                     DAEEVADYIIQTLNLGWELYEPTRGLN"
     misc_feature    2331..2351
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.85"
                     /tool="antismash"
     misc_feature    complement(2517..2532)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 22.59"
                     /tool="antismash"
     gene            2674..3366
                     /locus_tag="CPY53_RS19250"
                     /old_locus_tag="CPY53_19270"
     CDS             2674..3366
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819868.1"
                     /locus_tag="CPY53_RS19250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19270"
                     /product="pectate lyase"
                     /protein_id="WP_016819868.1"
                     /transl_table=11
                     /translation="MKTNTAKVLKKGMSIALSGMLIALFVGNYSAHAAPEVVHKTILVK
                     AGEVYDGKGKTVVADPDTLGDGSQKEAQKPIFKLENNATLKNVIIAAPAADGVHVYGNG
                     TISNVTWEDVGEDALTLKEPGTVNITGGGAFHAYDKVFQINAEGTINIKNFRADDIGKL
                     VRQLGGSTFRVNMTLDNSDISNVKDSILRSDGPNSKAKITNTRYHNVKQLFKGFKSGNT
                     SESGNTKY"
     gene            3504..4541
                     /locus_tag="CPY53_RS19255"
                     /old_locus_tag="CPY53_19275"
     CDS             3504..4541
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013308931.1"
                     /locus_tag="CPY53_RS19255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19275"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_017426257.1"
                     /sec_met_domain="APH (E-value: 6.3e-13, bitscore: 47.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVLLHFIQKSWVAMNLFHQYVSHDGTLNDTLVHSREILYTGTNG
                     RHVERFYVSSSESYIFKPLTNDDQKGRERWVYEHVLPALSPIYPQLLACSDTDADGGGE
                     WMVFEDLGPLHHLHADETLLQAVGFVARWHALPPGRFAGMPLRGPKPLIQEMVSELHIR
                     KPDILELCSSLGFSKQHMQRIYAQLEHLSFSHQLVLSHGDLHPGNYALSGEQLKVLDWE
                     HVHLNTPLWDVYHLIDMSHPLFPRHMTSKLRIRMLDTYLEQLELLGIQVDRTAFIQEYG
                     MFAVVFSLWMLLLITSDLQRIETELHRNSNKWSKEQLESQLDETLACLNQCTAMMDWGQ
                     VQPCK"
     misc_feature    3520..3533
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.72"
                     /tool="antismash"
     gene            4598..5596
                     /locus_tag="CPY53_RS19260"
                     /old_locus_tag="CPY53_19280"
     CDS             4598..5596
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014279969.1"
                     /locus_tag="CPY53_RS19260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19280"
                     /product="glycosyltransferase"
                     /protein_id="WP_017426258.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.7e-11,
                     bitscore: 41.6, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVGLVMRKIQFAEAQGPRIFAERLKQIGLELGVDIVFVSPERH
                     VSSHDWLPGYEHEKGDLVNYDIVLDQLHEQQIEHVIYTVSGFTYLNMFFKNSVLFPHSF
                     PDPALTGYEMMKPFYQIVDKAIVQTAFLKQEMASKFGVTDVTVIPIGFNERLVEKHFDP
                     SQVVENRVMWIGRDEENRRPDLVLEYARHNPDKDVYMVFGGERYKESMKKYDIPDNVKL
                     QFALTQDEVFALMNTAKVYWSCSKFDTFAMPLTEALAMGKIVVKPEHPCYGHISSTHSF
                     SGNEKNWFELVNMAAASPRRVSAENQTYAMEQFSSQVMKQGYRDFFDGWLS"
     gene            complement(5670..6878)
                     /locus_tag="CPY53_RS19265"
                     /old_locus_tag="CPY53_19285"
     CDS             complement(5670..6878)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369570.1"
                     /locus_tag="CPY53_RS19265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19285"
                     /product="MFS transporter"
                     /protein_id="WP_017426259.1"
                     /transl_table=11
                     /translation="MSTQENMTANRFPPSLLWLTLGAFAIGMTEFVIMGLLPNVAHDLH
                     VTIPQAGQLITSYALGVAIGAPVLTVLTHKVPQKKLLCLLMSIFILGNLFSVIAPNYEL
                     LIAARMATALSHGTFLGAGSLIAARLVRADKRAGAISMVLTGLTVANIIGVPFGTFIGQ
                     QLGWRASFGAIVVIGLISLFGIIRYIPVIQQDKPSSLKQEVKSLFNPKVLLMLLTGAVG
                     CGSLFTVFTYITPMLTDISGFAEHSITWILVLFGLGVTIGNIVGGKLADWKLLPSLVAN
                     YAVLAIILAILTFTLQNKVLAVITVFIWGIAAFGIMPGIQVRIMNLAYEAPLLASTSSH
                     SALNLGNAGGAFIGGVVINQMGLPAIPWVASLITVGGLLLMLVSYMMDRKTAHTEAIAE
                     IQS"
     cand_cluster    6757..27353
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    6757..27353
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[16756:17353](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      16757..17353
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
     gene            7098..8021
                     /gene="cysK"
                     /locus_tag="CPY53_RS19270"
                     /old_locus_tag="CPY53_19290"
     CDS             7098..8021
                     /EC_number="2.5.1.47"
                     /GO_function="GO:0004124 - cysteine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /gene="cysK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819871.1"
                     /locus_tag="CPY53_RS19270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19290"
                     /product="cysteine synthase A"
                     /protein_id="WP_017426260.1"
                     /sec_met_domain="PALP (E-value: 2.3e-70, bitscore: 235.5,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLKVVHSITDLIGDTPCVRLQRLTGPQDAEVYVKLEYFNPSGSV
                     KDRAAGNLIAEAEKAGHLKPGGTIIEPTSGNTGIGLAMNAAARGYRAILVMPSNMTKER
                     INILKAYGAEVVLTPAEERMPGAIRKALELGAEIEGSFIPHQFENEANPDIHRTTTALE
                     ILEQTEGRLDVFVASSGTGGTITGTGEVLRQHLPDLRIVVVEPKGSPVLSGGKPGPHKL
                     VGTSPGFVPTVLNTEVYDEIIQVSDEDAIAMTRAIAAQEGILVGPSSGATIWTAIQEAR
                     RLGAGKRVLCIAPDTGERYLSMGIFG"
     gene            8842..8988
                     /locus_tag="CPY53_RS19275"
                     /old_locus_tag="CPY53_19295"
     CDS             8842..8988
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="CPY53_RS19275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19295"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_226888859.1"
                     /transl_table=11
                     /translation="MFDLDLRKSYEASELSPQASIIKTTIKVSKAVCKTLTCICTGSCS
                     NCK"
     CDS_motif       8842..8895
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MFDLDLRKSYEASELSPQ"
                     /locus_tag="CPY53_RS19275_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8896..8988
                     /prepeptide="core"
                     /locus_tag="CPY53_RS19275_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="14.70"
                     /molecular_weight="2943.6"
                     /monoisotopic_mass="2941.6"
                     /core_sequence="ASIIKTTIKVSKAVCKTLTCICTGSCSNCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MFDLDLRKSYEASELSPQ"
                     /leader_location="[8841:8895](+)"
                     /alternative_weights="2961.6"
                     /alternative_weights="2979.6"
                     /alternative_weights="2997.7"
                     /alternative_weights="3015.7"
     gene            9055..9996
                     /locus_tag="CPY53_RS19280"
                     /old_locus_tag="CPY53_19300"
     CDS             9055..9996
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686236.1"
                     /locus_tag="CPY53_RS19280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19300"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_226888857.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.3e-22, bitscore:
                     76.6, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKPNIYNWHVARLTDHFSCGATVGQPLTILFIDTGVDKSHSEIQ
                     GNLVEAECKSFVPYEPCISDYVGHGTQMVSSVTGKYILKGICPFARVVVYKITDKKGIS
                     KLEWLYRALEEGIAKGYPIINVSYRTEYEVDLFEFNRFQALVDCANAQGIWVVCSAGND
                     GRDITQEYRVPANLKGVYPIGSTNKNGDISGFSNTLNDQFFAPSGDEYEINYNNDWVMV
                     AKSSFDTEDYLYEVLGFDKAYTVGIGTSIASALFSGVVASLSGELIAQGMNAGRTEMEC
                     LLRQGARLIDVQRNYYEVSLAGSIRALRQMRG"
     gene            10001..13084
                     /locus_tag="CPY53_RS19285"
                     /old_locus_tag="CPY53_19305"
     CDS             10001..13084
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686237.1"
                     /locus_tag="CPY53_RS19285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19305"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_016819875.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.1e-111,
                     bitscore: 372.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.1e-12,
                     bitscore: 43.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.4e-24, bitscore:
                     84.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLENFEISENYMYRKTLLGMEHYTQIFDHEQLDDDEYLDRLVRFV
                     QQQGLIDSIYVSSPSTYAALQSLEQGRTLKSKKKRNLILSLSKFISRAICRPTPFGLFA
                     GVGISRFGKTGGAGEHVVWATPDYSLIYRLIGLFHGDADVRNELRLSVNNTSYIDHHRL
                     VISYQTLFAADQEERSTENISILKTPVIDFIMKILDKEQQTFLQLMQAIKDAFGVDDTI
                     STDFLQQLIEQGFLVSEMIPNPRDTAPLEHLIRTLKLLAAPKAAYYSDILERVGQAIQD
                     ITVAAVKREGIEAVRKLVQLILPDYQGDLVKIDVRLNQVNEILLSDSDRQSLAQIASIL
                     SMLSTYRKEDTLSDYRQQFTEKYGVYEEVPLLQLFSKTLGLGKPEEYKSHYQNGDKYRH
                     KDEGRFRQLKALIAEWQTEALVNHSDIVLDEVKIQQLSELSLENVHVSFDLYYSCMENE
                     QGEVTFYLNNRAGSLEACQSFGRFAYMFDKDSRDEIFNFVRNPKDQKAGESGAEISFYP
                     FSPKITNIMTAGPTPDQSMDMATFPENRKLDVSQLLVGVEDSGYFYLKHRETGELVFPK
                     LSSMYNTELAPYLIRFLNDINLQYQTGWSHLEEYLYDSSFTPRVTYKNIIICPKKWTLY
                     ADKQLQSEEQFLAFLEDWIIKYNIPRYVYLVELDNKLLLDLDRHHHRKLLHKEYTRNPE
                     GKAAVIMETEKELFASANRYMEECVFFCKSPMFQYLPIDRLSAQATDKSLNKVLSSSVN
                     AVYYPGSDWISLQVYYNQEMLTDLLGSAFKTFMDNSAEYFIDQVFFVQYADKEPHIRLR
                     CKMSGSVEHQRFTALNYVFDFLNTVTSSGLVSSYSVVPYRPEILRYGGAAFIEQAERLF
                     AIDSYLVSGYYAGKRSINATDQMLFCCTGLFEVVNCAYPLAEDQLKAMAAIIDPKKFRQ
                     EYREHKEALFQRIQQTRSISLPASDTGDRLWQYAAYFTAIREADDRTNYYDDIMFSIMH
                     MFCNRVFGLDREKEELALHLCYYSLEDYLQVSKYHVAY"
     aSDomain        10448..10726
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CPY53_RS19285_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.60E-14"
                     /identifier="RREFam001.1"
                     /label="CPY53_RS19285"
                     /locus_tag="CPY53_RS19285"
                     /protein_end="242"
                     /protein_start="149"
                     /score="43.9"
                     /tool="antismash"
                     /translation="LSVNNTSYIDHHRLVISYQTLFAADQEERSTENISILKTPVIDFI
                     MKILDKEQQTFLQLMQAIKDAFGVDDTISTDFLQQLIEQGFLVSEMIP"
     gene            13095..14366
                     /locus_tag="CPY53_RS19290"
                     /old_locus_tag="CPY53_19310"
     CDS             13095..14366
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426262.1"
                     /locus_tag="CPY53_RS19290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19310"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_107735013.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-49, bitscore:
                     167.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVKQVPGNLSEIVRQSAEIYKDIDTVTLLIKKHAMHDYPEMELI
                     SLASGYPGISLLLDKLDEVYPGEGWDALAFKYNQEIVRLIGNIPFHSLSLYTGLAGVIY
                     LFNECSRGSTRYTNVLSQTLDMFLSSYGEFYEETRGKLEDSLIEDSDLDLISGWTGIAA
                     ALMEVKERQDRYAGKLDAVLLKILQLITDAVGKLRHFGELPEQTIYYNLGMAHGITGAI
                     NLLAVAHLRRYPLTGLREVLEVAKTFLLGNIREWNGTLVIPNMFTPDESAETSRNPGYH
                     RDAWCYGTPGASVAMFRLGLALEDKALQQQALQLFNTVYSRPDSLRKVISPTICHGYAG
                     LLLIQHHFSRTAAIPFKNDFLHRMLSYRNTQEAVPFTDLEGSVDDPLSLDKVGLLDGCA
                     GVLLTLLTCDNENLSTWKQMLVFS"
     gene            14382..14939
                     /locus_tag="CPY53_RS19295"
                     /old_locus_tag="CPY53_19315"
     CDS             14382..14939
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819877.1"
                     /locus_tag="CPY53_RS19295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19315"
                     /product="DUF5823 family protein"
                     /protein_id="WP_016819877.1"
                     /transl_table=11
                     /translation="MFILLKEIITVMVGLITDFLSFQLDAYFYIWFLVLFISSLAATLV
                     QRSEGTITYSTAECVGINVLVVVLYLVIGTILARYFASFEDQQIVAGDKIMLYKISFML
                     TSAVIIVDIILDRLKRGRKFSYSLEFLAGSAVCFLLFQLSNQTDWIGTKLSLSYIVMVA
                     IAAGVYTMAMKFLLEYENHKEK"
     misc_feature    complement(14389..14402)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.81"
                     /tool="antismash"
     gene            14954..16747
                     /locus_tag="CPY53_RS19300"
                     /old_locus_tag="CPY53_19320"
     CDS             14954..16747
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426264.1"
                     /locus_tag="CPY53_RS19300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19320"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_081317629.1"
                     /transl_table=11
                     /translation="MELNMESTAYKKIGEEKQTAHSLLELIKIARWPKLALAWSIVFTL
                     ISAAFSLVLPIITGKLVDKISAMELTIQTAAVLISLFLAGGILNAVSSLLLRYVGSKFF
                     QELRLKIWEKIIHLPVNYFDNNENGKIISRMTNDLAIVSNFLAITLPSILADVLMVTGC
                     IIMLFVLDWRLMSVLVALIPITALLIYPIGRRMNRVAIEAQDAAADFSGELSKILYNIR
                     FIKATTSEKLEMKYTREILGRIFRLNIKEGILSAVIEPIVTIIIMLALVGMFWYGSAGI
                     AAGHITTGTLVSMIFYLFTMVSPLTQLSSFFSQYQKAKGASKEIYTIYNQQDEKQEKLG
                     SVPDMKSHDQNSDILHFANVSFSYNQGQPVLSNVELTFRGGTTTAIVGPSGSGKTTIFS
                     LIEKFYSEYNGEIYYNNVYLDKIRTEEWRRKISYVMQDSDLLVGSVRDNLVYGLNRDAD
                     DHEIYAALDTVGLKEVIYQLPDGLDTFVGERGVKLSGGQKQRIQIARCLLSDHEILLFD
                     EATANLDSESEQLVHDVIKLLSKNKMTIVIAHRLSTIYKADQIIFLDKGEVTGVGTHHE
                     LMSWHDKYRDYVQFQLPTQLS"
     gene            16757..17353
                     /locus_tag="CPY53_RS19305"
                     /old_locus_tag="CPY53_19325"
     CDS             16757..17353
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686238.1"
                     /locus_tag="CPY53_RS19305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19325"
                     /product="accessory gene regulator AgrB"
                     /protein_id="WP_242210537.1"
                     /sec_met_domain="AgrB (E-value: 4.2e-32, bitscore: 109.2,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALYHQLSTWIIDKYFQDEELEAEKRAYVLYYLENILAGTEKILL
                     VLVSACLLGVLAETAAMLLSYTVVRRKSFGWHARKSHHCTWVSLLTFVFVPWLLKEVEW
                     NRFFLATLCLLSIILIARYAPADTECNPLVDPKFRRACRLQAIFLSIVFVFVAIALDFY
                     PWLIFGLFLEAVVITPVFYSIMRRSYANYEQYQEY"
     gene            17492..18820
                     /locus_tag="CPY53_RS19310"
                     /old_locus_tag="CPY53_19330"
     CDS             17492..18820
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819882.1"
                     /locus_tag="CPY53_RS19310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19330"
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_102998724.1"
                     /transl_table=11
                     /translation="MITSGIYFLQYTSYLVIYHMVSGNGLSVFRMNYKLLLFLVMYYFI
                     GITALNNFGLIVYLFLFVLLALYGWLTDKYESLWVIGFYAILTIFITTLLGYFITVISY
                     AVPYEYKNKWTAPFLTACSPPLIYLALRKLVSYLFPTPAVRLLKLYRIKLIVGASLILI
                     LGIIGLGLIIYSECESNNPYPSRLKIVLMLIGFTSIFLMTINWLYRFLRERELEKNKTE
                     QYLQLEAYIMEIEKMYEDIRGFRHDYTNILLMLDEGIRTGDLAMIKRIYESSIQPTASQ
                     LNGYSYSLDNLINLDVSELKSIITSKVLVAKKRGVDVKLEIDSGISEMYMDIIDLCRVI
                     SCFLDNAIDAALETCNPSINIVLIHEDDIQTVTIRNSYNHSALDGIKVNDLYKRNFSTK
                     ADNRGLGLYNIAKVLRSNKYVTLDTKKEPDFFTQTLIIKRATS"
     gene            18817..19596
                     /locus_tag="CPY53_RS19315"
                     /old_locus_tag="CPY53_19335"
     CDS             18817..19596
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819883.1"
                     /locus_tag="CPY53_RS19315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19335"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_017426267.1"
                     /transl_table=11
                     /translation="MNIFILEDQFIQQRIMEKMVRKSCEELGICCSNLIATSKPDLLLF
                     ESKACANNLYFLDIEISGCQMKGLEVAQEIRKYDMYGHIVFVTTHGHLSPLTFQYKVAA
                     LDFIIKDATQDEMEKKVREVLVVAHQRKPVLDVNDWFILDNKFTKFQISFSSIYYFETT
                     GVPHKIRLVSENRTLEFYGDLKDIEAKDPRLFRCHRAFIVNLMKVESIDKSKKEIIFQT
                     NQNSGEARRIIPVSRQLLKHLLDKMGDRSLLNRPVYE"
     gene            19643..20401
                     /locus_tag="CPY53_RS19320"
                     /old_locus_tag="CPY53_19340"
     CDS             19643..20401
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426268.1"
                     /locus_tag="CPY53_RS19320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19340"
                     /product="TraX family protein"
                     /protein_id="WP_242210538.1"
                     /transl_table=11
                     /translation="MEQRLSVQAEVKGIDATSLKLIAVLAMLIDHIGGLFFADFLGFQV
                     VGRITLPIMAFFVAEGYIHTRSFKKYTMRLALTGLASVVPYGLVFKDWCTSGNIMLTLL
                     MGLLAIWFYDNTTNPVLKYLAISALCVVSLLGDWSVIGVFLVLAFYVARKQQKIYNGWI
                     IAIIALMFIFGVIIIWAVPDSLSIMGINASTMNEYLYPFAIGGACIFALPLLSRYNGER
                     GKGPRTFFYLFYPLHLLALYLLKLAIDYYI"
     gene            20537..21514
                     /locus_tag="CPY53_RS19325"
                     /old_locus_tag="CPY53_19345"
     CDS             20537..21514
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426269.1"
                     /locus_tag="CPY53_RS19325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19345"
                     /product="aldo/keto reductase"
                     /protein_id="WP_017426269.1"
                     /transl_table=11
                     /translation="MKIMPLQKRGISDSRLVLGCMPFGGEWSHAPYTQEHVVEAERAVE
                     AAQSIGITMFDHADIYRMGKAEEIFGRILKGQPGLREQIVIQSKCGIFLPDGTLPGRFD
                     FSYDHIMESVDGILKRLGTEYLDILLLHRPDPLVEPEEVAKVFSELRTSGKVRHFGVSN
                     MNVSQICFLERSLTEPLIVNQLEMSLAHLHFIDQTVHVNQQAGTNVHFGEGLLEYCQTE
                     DIQLQAWGPLAHGRFSGGSLEGEPEHIRKTAELVQKLASEKGTTREAIVLGWLMKHPAR
                     IQPVIGSANPERIKACQDAERQSELMTREEWYQLYVSARGQALP"
     gene            complement(21598..22398)
                     /locus_tag="CPY53_RS19330"
                     /old_locus_tag="CPY53_19350"
     CDS             complement(21598..22398)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819886.1"
                     /locus_tag="CPY53_RS19330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19350"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_193191328.1"
                     /transl_table=11
                     /translation="MSLFEKIFNYQIVSRLDESGAFATTSQERVWLKSMLADSAATAAF
                     TPSTLDKLRQLLADDEPLEADGSLREKAGVPAASVYHPLLRKLRSILRSRSGICMTYKL
                     RNGRLHERMSGFPYKLEFSMVKKEWSLLWYNRRHRAFMSTKLSNIVTVTEDEILPEEAE
                     KFTQRILGILESRKEQGIIEIIPVYNGEMSRILYAFSCFEKEVEYVQEADTYRVTLTFQ
                     ADECEYVLSKIRFLGKRVKVVQGSRLISRMKETTAKALARYEEE"
     gene            complement(22373..23698)
                     /locus_tag="CPY53_RS19335"
                     /old_locus_tag="CPY53_19355"
     CDS             complement(22373..23698)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007428946.1"
                     /locus_tag="CPY53_RS19335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19355"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_242210539.1"
                     /transl_table=11
                     /translation="MARESFDKEIQFLRMLTLTSGAYNRQQFADRLGISVHTFDKTIRR
                     LKEIVQSVQQQLPAEQGHDFNEMLRFNYYESADPLLLFLFRAKSLKESESVRLSLLLTA
                     LQSQPMTTMELLDACCNGLPSDSALPDEKTIRSDLKYLVEVGVVCKEPGGRPYRYAVRN
                     DLVTELTDEELLDLYDFVDVMANTQLPSVQGYLLRDHLKKAMRRQLGDREMAEPFLYKY
                     HYYSRILDEAHIHPLLHAIRQRRCVNFLYFSASKRSMYGSQNTNPRFEKETEGREHTIL
                     PLQVIYDHQYGRWYVLGHVGGKGIMKFRMEGMTQLVEGKPVPEQLYADLLAVLEEKMRY
                     SWLVDTGRPVKVRVRFFNPEGAKRNFIRERVLSQGQWGAITEEESESFIYEITVNGITE
                     IKPWIRSFGSSCEVLEPQRLRKEFRQEWKELQAYYEPVRENI"
     gene            23897..25465
                     /locus_tag="CPY53_RS19340"
                     /old_locus_tag="CPY53_19360"
     CDS             23897..25465
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369575.1"
                     /locus_tag="CPY53_RS19340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19360"
                     /product="limonene hydroxylase"
                     /protein_id="WP_242210540.1"
                     /transl_table=11
                     /translation="MFGRFKNEVLYPWVGKLSIYETIKQGLDPQGRLTDDHLPDDEEYW
                     AGHTMRWVAGGLDGAFGHHGAGGDGETEKIKELAHLLSRQCRKPGMKTRRETYVRLMEE
                     NALSLIDPLLDAVREHPAIQPDRLYEEARWLAEHGAHRNVVKVGIALLGLLETEQHHEL
                     ILTLAKHDEFTLYAAVAIRNISDQANEQLYNLALQVHGWGRIHVVERLEPARQEIRDWL
                     LREGFRNNVMYEYLAYECAHKGELHTAMAVPHIDRELFDGAGDILSALLAAGGPAESID
                     DYEHAAMVIGNYLRHAKTMCTTVKHLTIIMDIADFLDEEDDSWEARYEHEWTPELRKRY
                     ASVCQQMMDDPQWMKLVEQELHHADSPHLHCAIRAARMLALDVWPVLFDQLSKHPVKPN
                     LYFELSKTEDEQRACKLVAFAEKHLPLGEIASGPADVPGFGPEYEAHQCLGMLLQLLSS
                     YEGMGQKLVAIGLWSPVTSNRRAALHVLKEWPSEMWGEATIERLRCLSEAETEESIREQ
                     IREIL"
     gene            25485..26303
                     /locus_tag="CPY53_RS19345"
                     /old_locus_tag="CPY53_19365"
     CDS             25485..26303
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369576.1"
                     /locus_tag="CPY53_RS19345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_19365"
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_242210541.1"
                     /transl_table=11
                     /translation="MTDVKHGQGFIQPEMRDTILRELRALEQEEQVRIVYACESGSRAW
                     GFHSQDSDYDVRFIYVRPIEWYLSIFDKRDVIERPISNMLDINGWDLKKALHLFRKSNP
                     PLLEWLQSPIPYLEQYSVADQIRAISPLTFSPKSCMYHYLNMARGNYRDYLQGEQVKIK
                     KYFYVLRPLLACGWIERYNSMPPIKFVDLLAEFIPADTELYQVIEHLLERKKAGEELDM
                     EPQLSVVNDFIEQQIACFEQKAPLLQHMEGGRDQQLDEMFRAAVNEVWKT"
     misc_feature    26817..26830
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    complement(26956..26969)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.33"
                     /tool="antismash"
ORIGIN
        1 acaggaccta ccttgctgta tattgtgcag ttatggctgc ctacttttgg gcaacagttt
       61 atcggcatga cggaatcaga gtctctgagg ctattagttt attacaatat gggttcgctg
      121 gtttccgtgt ttgtattggt cattgtattg agaaaatggg ttaaacctgt tcatatcatc
      181 cttatttatc cttgcatttc cttgttggct tttggagcgc ttcttctttt caaatctggg
      241 gctgccgcca ttatctgtgc gagtgtcatc gggttttcaa tatcgggtgt acttcagctg
      301 acgttaaccg taatgagtga attttttagt caacgaaaag gacagattac cgggtttatt
      361 tataccgcaa cttcgctgtc ctatacgctc attcccgtgt ttacaggctt tcttttgaag
      421 cattctcaga tttccagtgt gtttatgctg gctattatcg tgaatgtact tggaatcgca
      481 ctggcggtat ttgttaactt tcgttacagt gccgtttttc ctgcaaaacg agaattgtct
      541 cctcaaattg tactggatac gaaataacta gcgactgaac ctaatcatct gcatgcttat
      601 tcagaatgcg ttatactatg aattattgtg aatgttcgac ttgaaactgt aattggggag
      661 tgagatagat atgggaaaaa tcgtaaagat aaatgatgta cggatcggtg aaggagcgcc
      721 taaaatatgt gttcccatgg tgggagaaac gttggagcag ttgaaggaag aggctgccca
      781 tttacgaaca ctcgacctgg atatcgtaga gtggagagtc gattttttcg agcatgtgga
      841 agatctggaa aaggtaaagg ctgccttaca tgaaattcgg tctattttag ccaatattcc
      901 actcgtattt acgttccgta gcgcccgaga aggtggagaa aaggaaatca gtgctgcaag
      961 ttatgtggaa ttgaatcgca ctgtggccga gacgggacaa gtagatatca ttgatgtaga
     1021 gctttttaat gaggaagctg atgtgaagac actggtagaa gcagcacaca agcataacgt
     1081 atatgtgatc atttctaacc acgatttcca aaagacgccg ccgaaggagg aaattgtgtc
     1141 ccggttgcgt aaggcacagg aattgggcgg cgatctgcct aaaatagcgg tgatgccaac
     1201 caatacagcc gatgtactga ccttactgga cgccacacgc actatggcag aagagtatgc
     1261 ggatcggccg attatcacaa tgtcgatggc gggaaaaggt gtcgtgagcc gtctgaccgg
     1321 agagctattt ggttcagcgt tgacttttgg tgctgccaag aaggcttctg caccgggaca
     1381 gattcctgtc actgaactga gagaaatatt gcaggtgctg catagccact cttaagagat
     1441 gcaattacta cccactagcg agcaaggaat tcatagtgaa cacaaaagga ggaccccatg
     1501 cgataagcat gctggggtcc tcctttttgt aatgcttaat tcaatccccg agtaggttca
     1561 tacaattccc aacccagatt cagtgtttga ataatatagt ctgcgacttc ttccgcatcc
     1621 aactgatcgg tatcgatctt ggagtgattc accgcgtaaa tgtcctgtct ggaacggaaa
     1681 agatcttcaa tttcctctaa cgtcttgttt tgcagattag ggcgggtgtc aatcagcatc
     1741 ttgagccgat ctttccagga atcccaattt aaatccaaga agaacacaat ggaggaagcc
     1801 aaacaagcct gcttcacctc ttcctgtaga aacgcgccac cgccaacaga aatgatttta
     1861 agacgcgtat tgctgcacaa cttcaaaata tgctcttttt caatctcacg gaaacgcttc
     1921 tctccgtaag ttttgaaaat ttctgttgta ggcatgttgt actcttgttc aatctcctga
     1981 tcaatatcca cgaaatcgcg atacagcttg cgcgctagat gggaaccgat cgttgttttg
     2041 cccacgccca taaagccgat gagcacaata ttttgttctt ttaatggaat ctcactattg
     2101 ttttgcacat aaccactctt ttctcaccag taatgttgag atgtaacgct tcaaagcact
     2161 aaatacatta tacgttcatc aaccgtgtca ttcaatagta tagagcacat cagcaatgag
     2221 gtatacgata aaagagactc tgattaccaa tggagtgata gaacagcagg taaaaaacta
     2281 ggtattcaag tgttatgtaa tgcgtaaatg gaagaaaaac aaacttgtac aagtataaaa
     2341 gaggcaatat tgtgtactta attgaaaaaa aggacatatt ttgccgaaaa acgtattgaa
     2401 attattggaa gtaggaatat aatagagtta tgcaaattgt aaatgtaatc gctctattta
     2461 caatttgtga ttgatttaat ttataaaaaa gaaagctact ttgaaccaaa aaccaagtat
     2521 acatatgcaa ataattaaat atcactttac ggacatgtat cggtcaatgg gttcattgta
     2581 cgaaggtggt gatacggtct acgcgcttac gctctagtca acgaagaatt ggagataaga
     2641 ataaaaaacg atctaggaga gggatgaatt gaaatgaaaa caaacacagc taaagtattg
     2701 aaaaagggca tgagtatcgc tttatccggt atgttaatcg cgttatttgt cggcaattac
     2761 tctgcccatg cagctccaga ggtcgttcac aagaccatac ttgttaaagc tggagaagta
     2821 tacgatggta aaggcaagac cgtagtggct gaccccgaca ccttgggaga tggaagccag
     2881 aaagaggctc aaaagcctat ctttaagcta gaaaataatg caacgctgaa aaatgtgatc
     2941 atcgctgcac ctgctgcgga tggtgtgcat gtatatggca atggcaccat ttccaacgta
     3001 acgtgggagg atgtcggtga agatgcattg acgcttaaag aaccaggcac ggtgaacatt
     3061 acaggtggtg gagcgtttca tgcatatgat aaagtattcc aaatcaatgc cgaaggcacg
     3121 attaacatta aaaactttag agccgatgat atcggtaagc tggttcgcca acttgggggc
     3181 tctacgttta gggtgaatat gactttggat aactcggata tttccaacgt caaggattcg
     3241 atcctcagat cggacggtcc taacagcaaa gctaaaatta cgaatactcg ttatcataat
     3301 gtaaaacaat tgttcaaagg ttttaaatct ggcaatacga gcgagtccgg caatactaaa
     3361 tactaatcgt tagcgtagga taggagtacg ataggaaagg ggctgtccaa caggtcgtat
     3421 gatctgatag gacatgcccc ttttttggta tgttaagtta accctaagat gatctgggct
     3481 tcgttcagaa cgaggactat gttatgatcg tgctattaca ttttatacaa aaaagttggg
     3541 tggctatgaa tctatttcat caatatgtga gtcatgacgg tactttaaat gatacgctgg
     3601 tgcacagtcg tgaaatttta tatacaggta cgaatggccg acatgtggaa cgtttttacg
     3661 tgtcctcctc tgaaagttat atatttaaac ccctgaccaa tgatgatcag aagggacggg
     3721 agagatgggt gtatgagcat gtgcttccag cattatcacc catctatccc caattgctag
     3781 cttgttccga tacagacgca gatggcggag gagaatggat ggtgtttgag gatcttggtc
     3841 cgttacatca tctacatgca gatgaaaccc tattgcaagc tgttggattt gtcgcaaggt
     3901 ggcatgcttt gccgccgggt cgttttgccg ggatgccatt gcgtggaccg aagccgctca
     3961 tccaggagat ggtttccgag ctgcacatac gcaagccaga tatattagag ctttgcagct
     4021 cactcggttt ttccaagcaa cacatgcagc gtatttatgc acaactggag catctatctt
     4081 tttcacacca gcttgtactg tctcatggtg atcttcatcc ggggaactat gcgctgagtg
     4141 gggagcagtt aaaggtattg gattgggagc atgttcatct aaacacaccg ctgtgggatg
     4201 tatatcacct gatcgacatg tcccatccgt tattcccccg acacatgacg tctaaattgc
     4261 gtattcgtat gttggacacc tatctggaac agctggagct gttggggata caggtagatc
     4321 gaacggcatt tatacaggaa tatggtatgt ttgctgtggt attttcgctt tggatgctat
     4381 tactaatcac aagtgatttg caaaggattg aaacggagct gcatagaaat agcaacaaat
     4441 ggtcaaaaga acaattagag tcccagttgg atgaaacgtt agcttgttta aaccaatgta
     4501 cagcgatgat ggattgggga caagtccaac catgtaagta gtcggtttaa ggcctagatt
     4561 ctatatagtt agccaaagaa ggtagggaaa taaatccatg aaaaaagtcg gtttggtcat
     4621 gagaaaaata caatttgctg aagcgcaggg tcctcgtatt tttgcagaac gtctgaagca
     4681 gatcggattg gaactgggag tggatatcgt atttgtatca ccggagcgcc atgtaagcag
     4741 ccatgactgg cttccgggct atgagcacga aaagggtgac ctagtcaatt atgacatcgt
     4801 actggaccaa ctccatgagc agcagattga gcacgttatt tatacggtat ctggttttac
     4861 ctatttgaac atgtttttca aaaacagtgt actctttcca catagttttc cagacccggc
     4921 actgacaggc tatgagatga tgaagccttt ttatcagatc gtggacaagg ctatcgtaca
     4981 gactgccttt ctcaagcagg agatggcctc gaagtttggc gtaaccgatg tgacagtcat
     5041 cccgatcgga tttaatgagc ggttggtgga aaagcatttt gatccctcac aagtggtgga
     5101 gaaccgggtg atgtggattg gtagagatga agagaatcgg cgtccggatc tggtactgga
     5161 gtatgcgcgg cataatcctg ataaggatgt ctatatggta tttggcggtg aacgctacaa
     5221 ggaaagcatg aagaagtacg acatcccgga caatgtaaaa cttcaatttg cattaacgca
     5281 agacgaggtg tttgcactga tgaatacggc gaaggtgtat tggagctgct ctaaattcga
     5341 cacgttcgcg atgccgctga ccgaagcgct agccatgggg aaaatcgtcg tcaagccgga
     5401 gcatccttgc tatgggcaca tcagctctac gcattctttt tcaggaaatg agaaaaactg
     5461 gttcgagctg gtcaatatgg ctgcggcttc acctcgccgg gtttctgcgg agaatcagac
     5521 atacgccatg gaacagtttt cgagtcaggt gatgaagcag ggataccgag acttttttga
     5581 tggttggtta agctgaacga cgaggcagga tgcgtggatt tagaccataa aaaaaggact
     5641 ttcgctctaa tgaacgaaag tcctttttct tatgactgta tctctgctat cgcttcagta
     5701 tgagccgtct tgcgatccat catgtagctg accagcatca gcagcagacc gccgacagta
     5761 atgagtgatg caacccatgg aatggcgggt agccccattt ggttaataac gactcctccg
     5821 ataaaagcac cgcctgcgtt gcctagattc aatgcggaat ggctggaggt agaggctagc
     5881 aaaggagcct cataggccag attcatgata cgaacctgaa tccccggcat gatgccgaat
     5941 gcggcaatcc cccagataaa gacagtgatc acggccagta ccttgttttg aagcgtaaac
     6001 gtcagaatgg ccagaataat ggccagtaca gcatagtttg caaccaagga cggaagcagc
     6061 ttccaatctg cgagcttgcc gccaacgatg ttgccaatcg tgacacctag gccgaacagg
     6121 acgagaatcc aggtaatgct gtgttcggca aagccactaa tatccgtaag catgggcgta
     6181 atgtacgtaa agacagtgaa caagctacca cagccaactg cacctgtgag cagcatcagc
     6241 agcacttttg gattaaacag gcttttgact tcttgcttga gactggaagg tttgtcctgc
     6301 tgaatcaccg gaatgtaacg aataataccg aagagagaaa tcaagccgat cacaacaatg
     6361 gctccaaagg aagcgcgcca gccgagctgc tgcccgataa aggtgccaaa gggcacgcca
     6421 ataatattcg ccacggtcaa tccggtcagc accatagaga tggctcctgc ccgcttatca
     6481 gcacgaacca gccgggcagc gatcaaggaa cctgctccca agaaggttcc gtgcgataac
     6541 gcagtagcca tacgggccgc aatcagcagt tcgtagttag gagcaatgac ggaaaaaaga
     6601 ttgcctaaaa tgaatatgga catcagcaga cacaacagct ttttttgcgg aaccttatgg
     6661 gttaatacag taagcacagg tgcgccaatg gccacaccaa gcgcgtaact ggtgattaat
     6721 tgcccggctt gcggaatcgt aacatgaaga tcatgggcta cattgggcag aagtcccata
     6781 atgacgaatt cggtcatgcc gatggcgaag gcaccaaggg ttaaccatag caaggagggg
     6841 gggaagcgat tagctgtcat attttcttga gtactcataa gtttcttgta tcctcctgaa
     6901 aaaatagtaa tgcgagtata tcattccagg caacatctgg cgacccattt tgcaagaatt
     6961 ttacatacta agttgataag gtttgtgtaa tttacaaaag cgacaggttg gaaggagcca
     7021 attatgttat tttggtggta gtatgatatg aagataggaa atgacgttgt aaggaatgat
     7081 ccggggagga tataacaatg acacttaaag tggtacatag tattacggac ttaatcggag
     7141 atacgccttg tgtgcggctg caacggctca caggaccgca ggatgcggaa gtgtatgtga
     7201 agctggagta ttttaatcca agcggcagtg ttaaagatcg ggcggcgggc aatctgattg
     7261 ccgaggcgga aaaggcggga catctcaagc cgggaggcac gattattgag ccaaccagtg
     7321 gcaacacggg gattggtctt gcgatgaatg cggcagctcg aggttaccgt gcgattttgg
     7381 taatgccttc gaatatgacg aaggaacgga tcaatatttt aaaagcctat ggggctgagg
     7441 tcgtactgac accagcggaa gaacggatgc caggagcgat tcgtaaagct ctcgaactgg
     7501 gggcagaaat tgaagggagt tttatcccgc atcagtttga aaatgaagca aatcctgata
     7561 tccatcgtac aaccacggca cttgaaattt tggagcagac ggaggggcgg ttggatgtgt
     7621 tcgtcgcttc ttcgggaacg ggtggtacca ttacgggtac aggtgaagtg ctgcgccagc
     7681 atttgccgga tctgcggatt gttgtggtcg agcccaaggg ttcgcccgtc ctatctgggg
     7741 gaaaacccgg tccgcataag ctggtgggaa cgagtccggg ctttgttccc accgtgctga
     7801 atacggaagt gtatgacgaa atcatacagg tttccgatga ggatgcgatt gcgatgacac
     7861 gggcgattgc tgctcaggaa gggattctcg tcgggccctc cagtggggct acaatatgga
     7921 cggccattca ggaagcccgg cgtttgggag caggcaaacg ggtactctgc attgccccgg
     7981 ataccggaga gcgttatctg agcatgggga tattcggata aaaagatggg gatcgggtca
     8041 aagagattcg actcatttat atgtaagatc cagcctcatt aatcgaagtt acagaagtga
     8101 attggcgata tggtagacat aaacattgaa tacatctttg ccatattcat aggttaattt
     8161 cactcctgac aaatcaataa gccacaattc ataaggttat ggctaattaa ttgtcgatta
     8221 tagcttatat tcgtgagaat tttaaaagtc tcacggttca tgttccgttc ttcgacctta
     8281 tttgtttctt caggatcctc ttgaaaaaac caagtaatca gagaaggaaa caccaagcct
     8341 attctccatt tcagcaagag ctgcctcaaa cgggtcaact tatgagatgc cgtgtacacg
     8401 tagtgcgtcg gtcaattcct ttacagtcat gtcctgtttg aaaaaaatcg cagttcgtcc
     8461 acaagatcca gcgtatcgta aacatagggc gagcgctttt tgctaagcat ctcttcttca
     8521 gccgacttat acgagacacc tgtataggaa cataccggat tcttgcaagc atccgtcatg
     8581 ctctaagcgt caatcgttcc gctctgtgtc ggtatttttt ttgtcatgcc gcatgggaag
     8641 caaaatgact gcaatttagg aggtttggaa taccttttag gaataaagtt taaaaaacgg
     8701 gagaattaga tatattcttt attcatcgac agcaagatat gacatacagt cactcacaat
     8761 aaacatgatt aaggggtacc actgaaatca tgtttattag aatttaattt agagaggaag
     8821 aggaaaatga aagtagatca aatgtttgac cttgatttaa gaaagagcta tgaggccagt
     8881 gagcttagcc cacaagcttc aatcatcaag acaaccatta aggtatccaa agcagtatgt
     8941 aaaactctta cctgtatctg taccggttct tgttccaatt gtaaataatt cataagcgat
     9001 tcgtaagtca ggggtagtga aatgggctac ccctacttac attatggaga ttgcatgata
     9061 aaacctaata tatacaattg gcatgtagcc cggctaaccg atcattttag ttgtggtgca
     9121 actgttggtc agccgcttac tatcctgttt attgatacag gcgtcgataa atcccactca
     9181 gagatccaag gtaatctagt tgaggcagaa tgcaagtcat ttgtacctta tgagccttgt
     9241 ataagcgatt acgtcgggca tggtacacaa atggttagct ctgttaccgg caaatatata
     9301 ttgaagggga tatgcccttt cgctcgggtt gttgtctaca aaattacgga caaaaaagga
     9361 ataagcaagc ttgaatggtt gtatagagcg ctggaagagg gtattgctaa aggatatcca
     9421 attatcaacg tcagctatcg tacagaatat gaggtcgact tattcgagtt caataggttt
     9481 caggctttgg ttgactgcgc caatgcgcaa ggcatatggg tagtctgttc cgcaggaaac
     9541 gatggacgcg atattacgca ggagtacaga gtacctgcga atttaaaggg agtataccca
     9601 attggatcaa ctaataagaa cggggatatc tccgggttca gcaatacgct caacgatcaa
     9661 ttttttgcgc cgagtggtga tgagtatgaa atcaattaca acaatgattg ggtaatggtt
     9721 gccaaatcga gcttcgacac agaggattac ttatacgaag tgctgggatt tgacaaagca
     9781 tacacagtgg gtatcggtac gagtattgcc agcgccttat tcagcggagt tgttgcctct
     9841 cttagcggag agcttatcgc gcaggggatg aatgccggac gcacagaaat ggagtgtctg
     9901 ctccgtcaag gcgcgagact gattgatgtt cagcggaatt attatgaagt aagccttgcc
     9961 ggttcaattc gtgctttaag acagatgaga ggttgattgc atgttggaga actttgaaat
    10021 ctcggaaaat tacatgtacc ggaaaacgtt gcttggcatg gagcattata cgcagatatt
    10081 tgatcatgaa caactagatg atgatgaata ccttgacaga cttgtacggt tcgttcagca
    10141 gcaggggttg atagattcca tttatgtctc cagcccctcg acctacgctg cactgcaaag
    10201 cctggaacaa ggcagaacat tgaagtccaa aaaaaagcgg aatcttatcc taagtctaag
    10261 caagttcatt tcgcgggcaa tttgtagacc aacaccgttt ggactgttcg cgggagtagg
    10321 catttcccga tttggaaaaa cgggaggcgc cggggaacat gtcgtctggg caactccgga
    10381 ttatagccta atttaccgct taatagggct tttccatggg gatgcggatg tccgcaatga
    10441 attgagactg agtgtaaata acacctctta cattgaccat cacaggctcg tcatctctta
    10501 tcagactctg tttgcagcag atcaggagga acgaagcact gaaaatatat ctattctcaa
    10561 aaccccggtc atagatttca tcatgaagat ccttgataaa gagcagcaga cttttctgca
    10621 gcttatgcaa gctataaaag acgccttcgg cgtggatgac acgatcagca cagatttttt
    10681 gcagcaattg atagaacaag gctttttagt aagtgagatg attcccaatc ctcgggatac
    10741 cgctcctctg gagcatctga tacgtacact aaagctgctt gctgctccca aggcagcata
    10801 ttactcagat attttggaga gagttggaca agccattcag gacattacag ttgctgcggt
    10861 caaacgcgaa ggcattgagg ctgtccgaaa actagtccag cttatccttc ccgattatca
    10921 gggcgacttg gtcaaaatag acgtaagact gaatcaggta aatgaaattc tattgtcgga
    10981 cagcgatagg caatcgttgg cccaaatagc ttcaatattg agcatgcttt ctacgtacag
    11041 gaaagaggat acactttccg actatcgtca gcaatttact gagaagtacg gagtatatga
    11101 agaagtgccc ttattgcagt tgttcagtaa gaccttgggg ctcggcaaac ctgaagagta
    11161 caagagccac taccagaacg gagataagta caggcacaaa gatgaaggca ggttccgaca
    11221 gcttaaggcg ctaattgcgg agtggcagac cgaagcgctt gtcaatcatt cggatatcgt
    11281 gcttgacgag gtcaaaatcc aacagctgtc tgaattgagt ctggagaatg tccatgtctc
    11341 gttcgatttg tattattcct gcatggagaa tgagcaaggt gaagttacgt tttatttaaa
    11401 caacagagcc ggatcattgg aagcgtgtca gagcttcgga agatttgcct acatgtttga
    11461 caaggatagc cgtgatgaaa tcttcaattt tgtcaggaac ccgaaggatc agaaagcagg
    11521 ggagagcggc gctgaaatct cattttaccc attcagtccc aaaataacta atattatgac
    11581 ggcaggcccg acaccagacc aatctatgga tatggccacg tttcccgaga atcggaaatt
    11641 agatgtttcc cagctgctgg taggggtgga ggattcggga tacttttatc tgaagcacag
    11701 ggaaacaggc gaactggtat ttcccaaact cagcagcatg tacaatacag agctggcgcc
    11761 ttatctgatc cggtttctga atgatattaa tctgcagtat cagaccggat ggtcccatct
    11821 ggaggagtat ctctatgatt cttcttttac accgagagta acctataaaa atatcatcat
    11881 ctgccccaaa aaatggacat tatatgcgga taaacagctc cagagcgaag aacagtttct
    11941 ggcctttctg gaggattgga tcataaagta taacattccg cgatatgtat atttggtgga
    12001 gctggacaat aagctgttgc tggatttgga tcgccatcat catcgaaagc ttttgcacaa
    12061 agaatatacc cggaatccgg aaggcaaggc ggccgttatt atggaaacgg agaaagaatt
    12121 gttcgcttcc gctaaccgat atatggagga gtgcgtattt ttttgcaaaa gcccgatgtt
    12181 tcagtacttg ccgatagaca gattgtctgc acaggctacc gataaaagct taaataaagt
    12241 gctgagttct tcggtgaatg ccgtttatta tccaggttcg gattggatat ccctgcaggt
    12301 atattacaat caggaaatgc taaccgattt gctgggcagt gcatttaaga cattcatgga
    12361 caatagcgcc gagtacttca ttgaccaggt tttttttgtc cagtatgcag ataaggagcc
    12421 gcatatcagg ctaaggtgca aaatgtcggg aagcgtagag catcagcgtt tcacggcctt
    12481 gaactatgtt tttgatttcc tgaatactgt aacctcgtcc ggattggtta gttcctattc
    12541 ggttgttcct taccggcctg aaattttgcg gtatggcggc gcagccttca ttgaacaagc
    12601 ggagaggtta tttgctatcg attcttatct agtttcaggc tattatgcag gcaagaggtc
    12661 aattaatgca accgatcaaa tgttattttg ctgtaccgga ctttttgagg ttgtgaactg
    12721 cgcgtatccg ctggcagaag atcaattgaa ggctatggct gcgattattg atccgaagaa
    12781 attcagacag gagtatcggg aacacaaaga agcgctattt caaaggattc aacagacccg
    12841 ttccatatcc ttgccagcaa gcgatacagg cgacaggttg tggcaatacg ctgcatattt
    12901 cacggctatc cgggaagctg acgacagaac caattattac gatgatatta tgttcagcat
    12961 catgcacatg ttctgcaaca gagtgttcgg cctggaccgg gaaaaggaag agcttgccct
    13021 acacctgtgc tactacagtt tggaagatta tttacaggta agcaaatacc atgttgctta
    13081 ttgaggagga gcttatggcg gtcaaacaag tcccgggaaa tttatctgaa atagtcaggc
    13141 aaagcgcaga aatctacaaa gatatagata ctgtaaccct gctaatcaag aagcacgcca
    13201 tgcatgatta ccctgaaatg gagctgatat cattggcttc aggatatccc gggatcagcc
    13261 ttcttctgga taaactagat gaagtctacc cgggggaagg gtgggatgcg cttgctttca
    13321 agtacaatca ggagattgtg cgcttaatcg gcaatatacc gttccattca ttgtcactgt
    13381 ataccggatt ggcaggtgtt atttatctgt tcaacgagtg ttcaagaggt tcaacaagat
    13441 atacgaatgt gctctcacag acgctggata tgtttcttag cagctatggg gaattctatg
    13501 aggagacaag ggggaaattg gaagactcct tgattgagga tagcgacttg gatttgattt
    13561 caggatggac ggggattgca gctgcattaa tggaggttaa ggaacgccaa gacagatacg
    13621 ctgggaagct ggatgcggtg ctccttaaga tccttcaact gattacggat gctgtaggca
    13681 agctgagaca tttcggggaa cttcccgaac agaccattta ctataatctt ggtatggcgc
    13741 acggaattac aggagccatt aatttgctgg ctgttgcaca tctccgccgc tacccgttaa
    13801 caggattgag agaagtactg gaagttgcca agacttttct actcggaaat atcagagagt
    13861 ggaacggcac ccttgtcata cctaatatgt tcacaccgga tgaatccgca gagactagtc
    13921 ggaatccagg ttatcacaga gatgcatggt gttacggcac accgggagct tctgtggcta
    13981 tgttccggct gggattggcc ctggaggaca aagcgctgca gcagcaggct ctgcaattgt
    14041 tcaataccgt ctactccaga ccagattcgc taagaaaggt aatttcaccg acgatctgtc
    14101 acggctatgc aggcttgctc ctgattcagc accatttcag ccgtacggca gccataccgt
    14161 tcaagaatga ttttttgcat cgtatgttat cataccggaa tactcaagaa gcagtaccct
    14221 ttacagacct tgagggaagc gtcgatgatc cgttatctct cgataaagta ggcctgctcg
    14281 atggatgtgc aggtgtattg ctgacactgc tgacctgtga taatgagaac ttgagtacat
    14341 ggaagcagat gctggtattt agctaaaagg aggagacggt aatgttcatt ttattaaaag
    14401 aaattattac agtcatggtg ggactgatta ccgattttct ctcttttcaa ctggatgcat
    14461 atttttatat ttggtttctg gtcctgttta tttcaagctt ggcggcgacc ctggttcaac
    14521 gaagcgaagg gactattacc tacagcacag ccgaatgtgt cggaataaat gtgctagttg
    14581 tcgtattata cctagtaatc ggtacaattt tggccagata ctttgcaagt tttgaggatc
    14641 agcagattgt tgctggagat aagattatgc tgtataaaat ttcttttatg cttacatccg
    14701 ctgtaattat agtggatatt atactagata ggttgaagag agggcggaaa ttctcctact
    14761 ctttggagtt tcttgccgga agcgccgtgt gcttcttact gtttcaatta agcaaccaaa
    14821 cggactggat aggaaccaag ctgtcgctct cctatattgt catggtagcg atagccgcag
    14881 gtgtctatac aatggcaatg aagtttttgc tagaatacga aaatcacaaa gagaaatagg
    14941 tgattaagcc ataatggaat tgaatatgga gagcacggca tataaaaaga tcggtgaaga
    15001 aaaacaaacg gcccattcct tgctggagtt aatcaaaatt gcgagatggc ccaagcttgc
    15061 acttgcttgg agcatcgtat ttacactgat ttccgccgct ttttcattag tattgccgat
    15121 cattacaggc aagcttgtcg ataagatctc agctatggag ctgacgatcc agaccgcagc
    15181 tgtgcttatt tcgctgtttc tggccggagg gattttaaac gccgtgtctt ctctgctcct
    15241 cagatatgtg gggagcaagt tttttcagga actgcgactg aaaatttggg aaaaaattat
    15301 ccatttgccg gttaattatt ttgataacaa cgagaacggc aaaatcatca gcagaatgac
    15361 gaacgacctt gctattgtaa gtaattttct ggctatcact ctgccttcta ttctggctga
    15421 tgtcctgatg gtcactggtt gcatcatcat gttatttgtg ttggattgga gattaatgag
    15481 tgtactcgtt gctctgattc ctataacggc gctactaatc tatcccattg gaagaaggat
    15541 gaatagagta gcgattgagg cacaggatgc agccgcagat ttttctggtg agttatccaa
    15601 aattctctat aacatcagat tcattaaagc gacgacgtcg gaaaagcttg aaatgaaata
    15661 tactcgggag atacttggac gtatctttcg cttgaacatc aaagagggaa tattgtcggc
    15721 tgtcattgag ccgattgtca caattatcat catgctagct ttggtaggaa tgttttggta
    15781 tggaagcgcc ggcattgccg ctggacatat cactacaggt actttggtat ccatgatctt
    15841 ttatttgttt acaatggttt cgcctctgac ccagctcagc agttttttct cgcagtatca
    15901 gaaggccaag ggagcaagca aggaaattta taccatatat aaccagcagg atgagaagca
    15961 agaaaagtta ggcagtgtgc cggacatgaa aagtcatgat cagaattcgg atatcctgca
    16021 ttttgccaat gtttctttct cgtacaacca gggccaaccg gtattatcca acgtagagtt
    16081 aaccttcaga ggcggtacca ctacagcgat cgtagggcct tccggctcgg gaaaaacaac
    16141 aatattttct ttaatagaga aattttactc agaatataat ggagaaatct attacaataa
    16201 tgtatatttg gataagatta ggacggaaga atggcgtcgt aaaatatcct atgttatgca
    16261 ggatagtgac ttactggtag gatcagtgag agacaatctg gtatatggcc taaacagaga
    16321 cgcggatgac catgagattt atgcggctct tgatacagta ggcttgaagg aggtaattta
    16381 tcaattaccg gatggtttgg atacctttgt tggagaaagg ggagtcaaat tatcgggggg
    16441 acagaagcag cgaatccaga ttgccagatg cttgctttca gaccatgaga ttctgctgtt
    16501 tgatgaagct accgccaatc tggatagcga gtcagagcag cttgtacatg atgtaatcaa
    16561 gcttctctcc aagaataaaa tgaccattgt tatcgctcat cgtttgtcaa ccatctacaa
    16621 agcggaccag ataatctttt tggataaagg agaagtaacg ggggtaggca cgcatcacga
    16681 attaatgagt tggcatgata aatatcgtga ttatgttcaa ttccagcttc ccacacaatt
    16741 aagttaggga ggggcggtgg cgttgtatca tcaattgtca acgtggatca ttgataaata
    16801 ctttcaagac gaagaattgg aagcggagaa gcgtgcttat gtgctttatt atctagagaa
    16861 catactggct ggcacagaaa aaatacttct tgtattggtc agtgcctgtt tgctcggtgt
    16921 attagccgaa acggctgcga tgctgctttc ctatacagtg gtccggcgaa agtcctttgg
    16981 ctggcatgct cgcaagtcgc atcattgcac ctgggtcagt ctactgacct ttgtgtttgt
    17041 tccctggctc ttaaaggaag tagaatggaa ccgctttttt ttggcgacgc tctgtctgct
    17101 ttctatcatt ctgattgcca gatacgctcc ggccgatacg gagtgcaatc cattggtaga
    17161 tccgaagttc agaagagcat gcagattaca agctatcttt ttaagtatag tgtttgtttt
    17221 cgtggccatc gcactagatt tttatccttg gttaatattt gggctgtttc ttgaagcagt
    17281 cgtcatcaca ccagtattct attccataat gagaaggagt tatgccaatt atgaacaata
    17341 tcaagaatat taaagaacac agaaacaacc atacccagag actcaaggct aagctactgg
    17401 agcatatgag taaaagaggt gaaggaggag ggatttgttt cgggttgttc tatgaaccag
    17461 tcaacccaaa agtttggaaa ttgaacaata aatgattaca tccggcattt attttttgca
    17521 atacaccagc tatcttgtaa tatatcatat ggtcagcggc aatggtctaa gcgttttccg
    17581 tatgaattat aagctgctgc tgtttttagt catgtattat tttatcggaa taacagctct
    17641 gaataacttc ggactgattg tttacctatt tctatttgtg ctactggcat tatacgggtg
    17701 gttgaccgac aaatatgaat ccttgtgggt cataggcttc tacgccatcc ttaccatttt
    17761 tattacgaca ctgctgggtt atttcataac ggtaatcagc tatgcggttc cttatgaata
    17821 taaaaacaaa tggacggcgc ccttcctaac cgcttgttca cctccgctga tctacttggc
    17881 gctccgaaag cttgtgtctt atttgtttcc tactccggcg gtcaggcttt tgaagctata
    17941 tcggattaag cttatcgtcg gagcttcttt aatcttaatc ttggggatca tcggactcgg
    18001 actcattatc tattcggagt gcgagagcaa caatccgtat ccaagcagat taaagattgt
    18061 gttgatgctg atcggcttta cctccatctt cctgatgact atcaattggc tgtatcgctt
    18121 cctgcgtgaa cgtgagctag agaagaacaa gacggaacaa tacttgcagc tggaggctta
    18181 tattatggag attgaaaaaa tgtacgaaga catccgcggc ttcagacatg actataccaa
    18241 tatcctgtta atgctggatg aggggatcag aactggggat ttggcgatga tcaagcggat
    18301 atatgagagt tctatccaac ctactgcttc acagttgaac ggatattcct atagtctgga
    18361 taacctgatt aatctggacg tgagtgagct caagagtatt attacatcca aggtgctggt
    18421 ggcaaagaag cgtggagttg acgtaaaatt ggaaattgat agcggtatca gtgaaatgta
    18481 tatggatatt atagaccttt gcagagtaat ctcttgtttc ctggacaatg caatcgatgc
    18541 ggcattagag acctgcaatc cgtccataaa tattgtactg atccatgaag acgatattca
    18601 gacggtgacg atacgaaact cttataatca ttctgcactt gacgggatta aggtgaatga
    18661 tctctacaaa cggaactttt caacgaaagc ggacaatcga ggtcttggct tgtacaatat
    18721 agcaaaggtg ctgcgcagca acaagtatgt aactttggat accaaaaagg aaccggattt
    18781 tttcacgcaa acattaatta taaagagagc gacatcatga atatttttat tctggaagat
    18841 cagtttatcc agcagcgcat aatggaaaag atggtccgta aaagctgcga ggaacttggc
    18901 atctgctgca gcaatctcat tgccaccagt aagccggatc tcctgctttt tgaatctaaa
    18961 gcttgtgcga ataacttgta tttccttgat attgaaatct ctggttgtca gatgaaggga
    19021 ctggaagttg cccaggaaat cagaaaatat gatatgtatg ggcatattgt ctttgtaact
    19081 acccacggtc atctgtctcc gcttaccttc caatataagg tagcagctct tgatttcatt
    19141 atcaaggatg ctactcagga tgaaatggaa aaaaaggtca gagaagttct tgttgttgcc
    19201 catcaaagaa agcctgtgtt ggatgtcaat gattggttta tactcgacaa taaatttacg
    19261 aaatttcaaa tttccttctc cagcatttat tactttgaaa caaccggtgt tccccacaaa
    19321 atccgtctgg tttccgaaaa cagaactctt gagttttacg gcgatctgaa agatattgag
    19381 gctaaggacc caaggttgtt ccggtgtcat cgggcattta tcgtaaacct gatgaaggtg
    19441 gaatctatag ataagagcaa gaaggagatc atttttcaaa ccaatcagaa ttccggagaa
    19501 gcaaggcgca ttattcccgt ttcccgccaa ttgttgaagc acctcttaga taagatggga
    19561 gaccggagcc tcctgaacag acctgtttac gaatagaata gatacggagg gcatagttct
    19621 tcgggaagaa aaggggagga atatggaaca aagattatcc gttcaagcag aggtgaaagg
    19681 cattgatgcc accagtttaa aattaattgc agtattggca atgctaattg atcatattgg
    19741 agggctattt tttgccgatt ttttgggctt tcaggtggta ggcagaatta cattgcctat
    19801 catggctttt tttgtagccg aaggatatat ccataccaga agcttcaaaa aatatacaat
    19861 gcgccttgct ctaaccgggc tagccagtgt ggtgccttac ggattggtat ttaaagattg
    19921 gtgtacttcg ggaaacatca tgctaacgtt gttgatgggc ctactggcaa tatggttcta
    19981 tgacaacacg accaatcctg tgcttaaata cttggctatt tcggctcttt gcgtagtctc
    20041 tcttttggga gactggagtg tgattggagt gttcctggtt ctggctttct atgtggctcg
    20101 caaacaacag aagatttaca acggatggat tattgcaata attgcgctta tgttcatttt
    20161 cggagtcatc attatatggg ctgttcccga ttcgctcagc atcatgggca tcaacgccag
    20221 cacaatgaac gaatatcttt atccgtttgc gatcggcggg gcctgtattt ttgcactccc
    20281 tttgctatcc cgatataacg gagagagggg aaaaggccca cgaaccttct tctatttgtt
    20341 ttatccgctg catttgctcg cgctttatct gctgaagttg gctattgatt attacatata
    20401 agaagggctg tctaataagt aactaaaata aaatcagacg ggaaacgaca tgttttccgt
    20461 ctgatttttg cggtttgacg aactattcga atgttgatga agcaaggaat actttgaggg
    20521 ttcaaggagg agcagcatga aaattatgcc tttacagaaa cgtggaatct ccgatagtcg
    20581 gctggtactt ggctgcatgc cttttggtgg agaatggagc catgcaccgt atacacagga
    20641 gcatgtcgtt gaagcggaga gagctgtaga agctgcacaa tccatcggga ttacgatgtt
    20701 tgatcatgcg gatatctatc gtatgggaaa agcggaagaa attttcggtc ggattttaaa
    20761 gggacagccc ggattgcgtg aacaaatcgt aattcagtcc aaatgcggca tttttttgcc
    20821 ggatggcacg ctcccaggcc gttttgattt ctcatatgat catattatgg agtccgtaga
    20881 tggtatcttg aagcgtctgg gtactgagta tttagacatc ctgctgctgc accgtcccga
    20941 tccgctggta gagccggaag aagtagcgaa ggtgttcagc gagcttagga catccggcaa
    21001 agtacggcat tttggcgttt ccaatatgaa tgtaagccaa atttgttttc tggagcgtag
    21061 cctaacggag ccgctgattg ttaatcagct ggagatgagc ctggcacatc tgcattttat
    21121 agatcagacc gtacacgtga accagcaggc agggacgaat gtacattttg gcgaaggatt
    21181 gctggaatat tgccaaactg aggatattca gctccaggct tggggaccgc tggcgcatgg
    21241 acgttttagc ggaggttctc tggaaggaga gcctgagcat atccgtaaga cggcagaact
    21301 ggtgcagaag ctggcttctg aaaaggggac gacacgtgaa gcgatcgtcc tgggctggct
    21361 gatgaagcat ccggcacgga ttcagcctgt cattggcagc gccaatcctg aacgaatcaa
    21421 agcatgtcag gatgcagaac gccagagcga gctgatgacc cgtgaggaat ggtatcaatt
    21481 gtatgtcagt gcacgcggac aagccttgcc ataactcgtt taacaggccc tcctttcgtc
    21541 tcattagcag acggagggag ggcctttacg tggattcatc ctatatttct tcagcagcta
    21601 ttcctcttcg tatcgtgcga gggccttggc agttgtttcc ttcattcgcg atattaatcg
    21661 agagccttga acgaccttga cacgtttgcc gaggaagcgg attttggata acacatattc
    21721 acattcgtct gcctggaagg tgagcgtaac acgataggta tcagcttcct gtacatattc
    21781 gacctctttt tcaaaacagg aaaaagcata taaaatacga gacatttcac cgttgtatac
    21841 aggaataatt tcaatgatgc cctgttcttt gcgcgactcc agtataccga gtattcgttg
    21901 ggtaaacttc tcggcttctt caggaagaat ctcatcctcc gtaacggtta cgatgttgga
    21961 tagtttagta gacatgaatg cgcggtgtcg gcgattatac catagcagac tccattcttt
    22021 tttgaccatg gaaaactcca gcttataggg aaatccggac attcgctcat gcaggcgacc
    22081 gttgcgcagt ttgtaagtca tacagatgcc ggagcgggat cgcagaatgg aacgcaattt
    22141 acgcaggagc ggatgataaa ctgaagcagc aggaactcct gccttttcgc gtaggctgcc
    22201 atcggcctcc aaaggctcgt cgtctgcaag taattgccga agcttatcaa gtgtagacgg
    22261 ggtaaaagcc gctgtcgctg ccgagtctgc aagcatggac ttaagccaga ctctttcctg
    22321 cgaggtggta gcaaaagcgc ccgattcatc caaccgtgag acaatctgat agttaaatat
    22381 tttctcgaac aggctcataa taggcttgca gctccttcca ttcctgtctg aattccttac
    22441 gcagccgctg gggctccaat acctcacagc ttgatccgaa gctgcgaatc cacggtttaa
    22501 tctcagtgat tccattcact gtgatttcat agataaagga ttcactttct tcctccgtaa
    22561 tcgcacccca ttgtccctgt gacagtacac gttcccgaat aaagttgcgt tttgcccctt
    22621 cgggattaaa aaaacgtacc cttaccttca cgggacgacc cgtatcaaca agccagctgt
    22681 accgcatttt ttcctccaac acggctaaca gatcggcata aagctgttct gggacaggct
    22741 tgccctccac caattgggtc atgccctcca tacgaaactt catgattcct ttgccgccca
    22801 catgaccaag cacgtaccaa cgtccatatt gatgatcata gatgacttgc aagggcagaa
    22861 tggtatgttc acggccttca gtctcttttt caaatcgtgg gttggtgttc tgtgacccgt
    22921 acatgcttcg tttggatgcc gaaaaatata aaaagtttac gcagcggcgt tgccgaatgg
    22981 catgcagaag cggatgaata tgggcttcgt ccagaatgcg tgaataataa tggtatttat
    23041 ataaaaaagg ctctgccatc tcccgatctc cgagctgacg gcgcatggcc tttttaagat
    23101 gatctcgcaa cagatatccc tgcacagagg ggagctgagt gttggccata acgtccacaa
    23161 aatcatataa gtccagtaat tcctcgtccg tcagttctgt caccagatcg ttacggacag
    23221 catagcgata gggtctgccg ccaggctcct tacaaactac gccgacttcg accagatatt
    23281 tcagatcaga acggattgtt ttttcatccg gcagtgcact gtcggaaggc agcccattgc
    23341 agcaagcgtc cagcagttcc atggtggtca taggctgtga ttgcagcgct gtcagcagaa
    23401 gggataagcg gacgctttcc gattccttga gcgatttggc ccgaaacagg aataacaata
    23461 acggatcagc ggattcgtaa taattaaagc gcagcatctc attaaaatca tgtccctgtt
    23521 ccgcaggcaa ctgctgttgt acggattgga caatttcctt gagacgccga atcgttttat
    23581 caaaggtgtg caccgaaatg ccaagtctgt ctgcaaattg ctgccgatta taagcgccac
    23641 tggttagtgt gagcatgcgc aggaattgaa tttctttatc aaaactctct ctcgccatga
    23701 tgcattcccc gtttctgtag ccgttctccg aaaacaagta tccctttatt ctaacaggga
    23761 agggatgcag gaaaaaggta atttattcat ctttgtaata ctttcaccat gttcatgact
    23821 tccaaaataa aggattatag ggatataagg tagcacgata agtaagaagc aatacataac
    23881 agaagggtga tgcaacatgt ttggacgatt caaaaatgaa gtgttatatc catgggtagg
    23941 taagctttcg atttatgaaa caattaagca gggactggac cctcagggca ggcttacgga
    24001 tgatcatttg ccggatgatg aagaatactg ggcaggtcac acgatgcgtt gggtggcagg
    24061 agggctggat ggagcgtttg ggcatcatgg cgctggcgga gatggagaga ctgagaaaat
    24121 taaggagcta gcacacttgt tgtccagaca atgccgcaag ccagggatga aaacaagacg
    24181 tgagacgtat gtacgcttga tggaggaaaa tgcgctcagc ctgattgatc cgctgctaga
    24241 tgcggtgcgc gaacatccag caattcagcc ggatcgattg tatgaggaag cgcgttggct
    24301 ggccgaacac ggagcacatc gcaatgtggt gaaggtcggt attgcgctgc tcggattgct
    24361 ggagacagag cagcaccacg agcttatttt aacgctagcc aagcatgatg aattcacgct
    24421 atatgcggct gtagctatcc gtaatatttc ggatcaggcc aatgagcagt tgtataattt
    24481 agccttacag gtacatggtt ggggacgtat tcacgtcgtg gaacgactgg agccggcgcg
    24541 gcaggaaata cgtgattggt tattacggga aggattccgt aacaatgtca tgtatgagta
    24601 ccttgcttat gaatgcgctc ataaaggcga gctgcataca gccatggctg taccgcacat
    24661 tgatcgggag ttgtttgacg gagcaggcga tatactgtcg gctttgctgg cggcaggcgg
    24721 acctgcggaa agtatagacg attatgagca tgccgctatg gtcataggca actaccttcg
    24781 tcatgctaag actatgtgta cgactgtgaa gcatcttacg atcatcatgg atattgcgga
    24841 cttcctcgat gaagaagacg attcatggga ggcacgttat gagcatgaat ggacgccgga
    24901 attacgtaaa cgttacgcgt cggtatgcca gcagatgatg gacgatccgc agtggatgaa
    24961 gctggtagag caggaactac atcatgcaga ttcaccgcat cttcactgtg ccattcgcgc
    25021 agctcgaatg ctagcactag atgtatggcc cgtgctattt gatcaattaa gcaaacaccc
    25081 agtcaagcct aatctgtact ttgaacttag caagacagag gatgaacagc gggcatgtaa
    25141 gctggtggct tttgcagaaa agcacttgcc tctgggagag atagcttccg gtcctgctga
    25201 tgtgccgggc tttggaccgg agtatgaagc gcatcaatgt ctggggatgc tgctgcaact
    25261 attgtcttct tacgaaggga tgggacaaaa gctagttgct atcggacttt ggagcccggt
    25321 gacctccaat cgccgtgcag cgcttcatgt actcaaggaa tggccttctg agatgtgggg
    25381 agaggcaacg atagagcgcc ttcgctgctt atcggaagct gaaacggagg agtcgatcag
    25441 agaacagatt cgggaaatac tttaaggata agggagggaa caacatgaca gatgtgaagc
    25501 atgggcaggg tttcattcaa ccggaaatgc gcgacacgat tttgcgtgag ctgcgcgcgt
    25561 tggagcagga agagcaggtg cgcattgtgt acgcctgtga atcaggcagt cgggcatggg
    25621 ggtttcattc acaggacagt gactatgatg tacgatttat ttatgtaaga cccatagaat
    25681 ggtatttatc tatttttgat aagcgggatg tgattgagcg gccaatcagc aatatgctgg
    25741 atataaacgg ttgggatttg aaaaaggcgc tccatttatt tcgcaaatcc aatccgcctt
    25801 tgctggaatg gctgcaatct ccgattcctt atctggagca atattcagtg gccgatcaga
    25861 tccgtgcaat ctcgccgtta accttctctc cgaagtcctg tatgtatcac tatctgaata
    25921 tggcacgggg aaactatcgg gactatttgc aaggtgaaca ggtgaaaatt aaaaaatatt
    25981 tttacgtgct gcgtccgctg ctggcctgtg gctggattga acgttacaac agtatgcctc
    26041 ctatcaaatt cgtagacttg ctagcggaat tcattccggc agataccgaa ctttatcagg
    26101 tgatcgaaca tttgctggag cgtaaaaaag cgggtgagga actggatatg gagccgcagc
    26161 tttcagtggt gaatgacttt attgagcagc aaattgcttg ttttgaacag aaggcgcctt
    26221 tgcttcagca tatggagggc ggacgggatc agcaattgga cgagatgttc cgcgctgcgg
    26281 tgaatgaagt ttggaaaaca taagctggga aggagaagtg gagtatgcac atcacgctaa
    26341 aagcaaccgg aaacaatgcc gggatgattt cgcatttgct cgccaagaac ccttacaata
    26401 cgtatgatcg cacggaaaag ggtgctcgtg tacgcatggt gtacaccgtt tttacggagg
    26461 aagaggcaga aatcgtcatt caggcctcgc cagattcgat agatttggtc aaaaatagtc
    26521 cggatagcta tgacattaca caatatatta atgatcggga gtttgtaacc agcagcttgt
    26581 tttgcaccta tattcgcggc gcgcttggca cggccttgaa cggcaagccc aaggaagact
    26641 atgcagcatg ggtgacgcat ccttttgcgc tggagttatc gtttgggcct gttgcgtcag
    26701 atttgccgga tgctgtggtg gagggactat ttgcgccgct gggctatcaa gtgaccatcg
    26761 aacgagggaa agcggattat tcttttcagc tgaaaaatcg aagcaccgtc agatatgtca
    26821 cgctaagtgg ccatcagacg gtgcaatatg cgctgcgtca gttattgctg ttaattccag
    26881 tgttggataa ttataagcac tattatatta gcgaagaaga gtttgataag ctgaaacgtt
    26941 acggtgaagg ctggctgcaa gagcatccga tgcgcgagct catcattcga cgcacgcttc
    27001 attttaccaa tctgattgag caatttgagc aatctgattc tgctgctaca cagactgaaa
    27061 aacatgcggt ccaagaacaa aaccataatc acgaacagga tcagcagcaa gatcagtcac
    27121 tggaggaagg aaagcaacag cctgtaatgc ggctaaatga gctgcggtat caagccatta
    27181 tggatgtgat tcgcaagctg ccccgaagac agaaaatcgt agattttgga tcaggagaag
    27241 ggaagctttc ggctcggatg gctcgaatca agggcattga agagatttgg gctgtggagc
    27301 cgtctgcata tgcacaggtg agggctgtgg agcgttttgc caagctggaa agg
//
