LOCUS       NZ_CP023711            21422 bp    DNA     circular CON 06-APR-2024
DEFINITION  Paenibacillus polymyxa strain C12 chromosome, complete genome.
ACCESSION   NZ_CP023711
VERSION     NZ_CP023711.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5793823)
  AUTHORS   Sun,D., Qiu,J. and Shen,M.
  TITLE     De Novo Assembly of the Paenibacillus polymexa Strain C12 Genome
            Using PacBio Single-Molecule Sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5793823)
  AUTHORS   Sun,D., Qiu,J. and Shen,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2017) College of Biotechnology and Bioengineering,
            Zhejiang University of Technology, Chaowang Road, Hangzhou 310000,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 105.2x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022649565.1-RS_2024_04_06
            Annotation Date                   :: 04/06/2024 06:53:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,129
            CDSs (total)                      :: 4,973
            Genes (coding)                    :: 4,899
            CDSs (with protein)               :: 4,899
            Genes (RNA)                       :: 156
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 110
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 74
            CDSs (without protein)            :: 74
            Pseudo Genes (ambiguous residues) :: 0 of 74
            Pseudo Genes (frameshifted)       :: 26 of 74
            Pseudo Genes (incomplete)         :: 42 of 74
            Pseudo Genes (internal stop)      :: 21 of 74
            Pseudo Genes (multiple problems)  :: 13 of 74
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:37:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3636648
            Orig. end                         :: 3658070
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023711.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21422
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="12"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21422
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21422
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11422](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11422
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            complement(44..3484)
                     /locus_tag="CPY53_RS15805"
                     /old_locus_tag="CPY53_15840"
     CDS             complement(44..3484)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820224.1"
                     /locus_tag="CPY53_RS15805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15840"
                     /product="cellobiose phosphorylase"
                     /protein_id="WP_242210431.1"
                     /transl_table=11
                     /translation="MNTSLDQNILLRAGDLSFTFLSSGDVYKIAHGSTMINQLLTNSVD
                     GSLNNLYLRLYRPSGVSITPLLGVRSPGVIRQTDQQIIWEGFTAGVGYQVTFTLSRLGV
                     WFWDVTLQGDDVEADIVYGQDIGIADTAAVRSNEAYLSQYIDHTVYHDEQRGYTVCSRQ
                     NQPQSQAFPYIQQGSLTRTVGYSTDGFQFFGLSYKETNEPEALRRDTLANEVYQYEFAY
                     TALQSERVKLAGEARFTFYGLFQPSHPAAVTKLEYQDLVTKARDEVATVLADASETSIP
                     AHAASDLQAGRVAPAQTIGEPLRTLDLTDAEVNQLFPKRQEEERDGDTLLSFFTDSYEH
                     VVLKSKELRVERPHGHILMGGHYSGGKEETITTTSYMYGVFNSQLVIGNTNFNKMITNV
                     RNALNIPKTSGQRIYVGIQGKYRLLTMPSLFEIGFNYVRWYYKTADDTFIITNHTNADS
                     PEVRLHMRSASGKAYPFLITQQMCMHVNEYELPFHMEREGDDLLFRADSASLSAEAYPD
                     LLYRMHVEGAPLQHVSDAQALLQGGASPDASLVVLELGDSSEWTCIVQGWLHGRSTGKD
                     RAHKELHASFEDERERYREYFAELMNGFHLTLGQQETSELFRVNAVAWWYTHNMLVHYS
                     VPHGLEQYGGAAWGTRDVCQGPVEYFSAVQNFDEVRSILLTVFSHQYEDSGNWPQWFMF
                     DNYTHVQQEESHGDIIVWPLKVLGDYLTATRDYSILGENVPYTHRHTFDYTKQTATLME
                     HALKEIEYIRENFLHDTYLSAYGDGDWDDTLQPANAQLKQYMASSWTVALTYQVIRNFA
                     AVLEQAPANVVSEADKIAQDLHQMANGIRKDFNRYMLESGIIPGFVYMEEPGQPKLMLH
                     PSDTETGIHYRLLPMTRSMISQLLTPEQALAHEQLIREQFLCPDGVRLMNRPAQYDGGV
                     SSHFKRAEQAANFGREVGLQYVHAHIRFVEAMAKLGRKDDAWHSLKLINPVGIRATVPN
                     AEWRQSNAYFSSSDGKFNTRYEAQERFDELREGAVPVKGGWRIYSSGPGIYMNQLISNV
                     LGIRQSGEDLILDPVLPNDLDGLEFKFSFAGKPITFVYRMLQEHTSGEQGRAVLNGAPL
                     ESEPADDNRYRSGALRIKRETFEQALAEHDGVHRLEIIL"
     misc_feature    complement(3463..3478)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.04"
                     /tool="antismash"
     gene            complement(3498..5672)
                     /gene="bglX"
                     /locus_tag="CPY53_RS15810"
                     /old_locus_tag="CPY53_15845"
     CDS             complement(3498..5672)
                     /EC_number="3.2.1.21"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="bglX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019685868.1"
                     /locus_tag="CPY53_RS15810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15845"
                     /product="beta-glucosidase BglX"
                     /protein_id="WP_017425688.1"
                     /transl_table=11
                     /translation="MEQHLNSYLQNMTLEEKVDQLLQLVGGFFEEAGTEGQITGPMASL
                     GITEQTVHNVGSVLGLAGAQEAIRVQQAHLSKNRLGIPLLIMADIVHGFKTIFPIPLAM
                     GCSWDMELAEESATIAAREAAVSGVHVTFAPMVDLVRDPRWGRVMESTGEDPYLNSQFA
                     RAFVRGFQGNDLTNDTERVAACVKHFAAYGAGEGGRDYNTVDVSAWQLREYYLPSYKAA
                     LDEGCEMVMTSFNTVEGVAATGNKRLMRDLLRDEWGFDGVLISDWAAIKELIPHGIAED
                     EREAAKKALLAGVDIEMMTSCYNGYLPELIRSGQLDEALVDEAVMRILKLKQKLGLFEN
                     PLRGADPEREREVVFCEAHRAVAKELAIKSCVLLKNDSVLPLNRNQHIALIGPFAESGD
                     ILGSWSWSGSQEEAIRVVDGFQSKISSSLLTVAAGCSVDNITEEQYAEALHAASQAEII
                     VLALGERSDMSGEAGSRSNIRLPQAQLELVKRLKTLNKPMVAVLFNGRPLDLHGVIEEA
                     DAVLEAWFPGGEGGAAIADLLYGDAEPTGRLTMSFPQSVGQVPVYYNHFNTGRPQLDPN
                     TTERYVSQYLDVPNEPLFPFGYGLSYTDVAYDSLQLSGDTLIPGQELTVRVQVTNTGTR
                     PVEETVQFYVRDISGDTVRPMKELKDFCKILLAPGENREVEFTVTEPQLRYHHADLSFD
                     SDSGEFAVFTGPNSRDTTEGRFRLVKETGK"
     misc_feature    6049..6062
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.42"
                     /tool="antismash"
     misc_feature    complement(6104..6116)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     misc_feature    complement(6171..6183)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 21.58"
                     /tool="antismash"
     gene            6245..7498
                     /locus_tag="CPY53_RS15815"
                     /old_locus_tag="CPY53_15850"
     CDS             6245..7498
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017425689.1"
                     /locus_tag="CPY53_RS15815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15850"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_242210432.1"
                     /transl_table=11
                     /translation="MMKRTLGIILASTLLLGGALVGCSSKDDSSGKDANGKTTITMWGM
                     GAEGKLLPEIVKDFEKENPDIHVDVQALPWDNAHDKLLTAVASKSGPDVVQLGTSWVPE
                     LASAGALTDITPYISKYPELEAKNFFKGAVSTAQFEAKPVAVPWYTETRVLFYRSDLLK
                     QVGYNEAPKTWEELSDAAQKLAARGKGKYGISFSAKEQSMGFMFALQNGSKLVDEQGNP
                     LFNQAPFVDAVKYVNTFFQNGSNAVDIGIDSVQGLQGEGIVPMFISGPFMIKEIKSKAP
                     ELEGKWNIAELPGKVNNLSVLGGANLSIMKFSKHPEESAKFLAYMSKPETQLKWMELSS
                     NLPATTKSWEDAKLKSDPMLLTIRKQLDHSAALPQLAAWEEVSQQFIKSFERIYRGHAD
                     VQKEMDDFNQQATSIMKK"
     gene            7535..8419
                     /locus_tag="CPY53_RS15820"
                     /old_locus_tag="CPY53_15855"
     CDS             7535..8419
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014279338.1"
                     /locus_tag="CPY53_RS15820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15855"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_016820227.1"
                     /transl_table=11
                     /translation="MKGSSQKLAPYLFIGPSIILLTLFSLLPILLALVISFTDMDLSGL
                     VNYESIRFIGLENYTNVLLDPSFLKSIGNTLFFVIIGVPLVLIFSLSIAILINMGKSRA
                     FKVFRVVFYLPSVTNVVAVAVVWSYLYNPTLGLFNYVLGLVNLGPVPWLTDPTVAKISL
                     IVLAVWRGIGLNMIIFIAAIKGIPGSYYEAAQLDGANTWQQIRYITLPQLRYAIFFVSI
                     TTMIGWLQFFEEPFVMTKGKPLDGTLTASLFIYNNGFQFSKFGYAAAGSFILFFAIIAV
                     TLIQFRLQNKAES"
     gene            8438..9292
                     /locus_tag="CPY53_RS15825"
                     /old_locus_tag="CPY53_15860"
     CDS             8438..9292
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013308375.1"
                     /locus_tag="CPY53_RS15825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15860"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_013368987.1"
                     /transl_table=11
                     /translation="MKTAVQQARANTRSGEKTFQWFVAILLTVGGLLMVLPFAWMILSS
                     FKTEGEVTKIPPTIWPEHFTLDNFKILFDSMAFGTYLTNTLIIVLASFFGLFLNAMAGY
                     GFAKFQFKGKGFLFYLVLATMMIPGQVTMIPVYLILNQMGLTNSMLGIVLPGLVGAFAI
                     FLFRQFMSDIPEELLEATRLDGAGEFRTFLQIVLPISTPIIAVQAILTFIGGWNSFLWP
                     LIIANDEKLYTLSVGLSLLKGQNESQFALQMAGSTFMVVPIMIIFIIFQKYIIENYTIS
                     GIK"
     misc_feature    complement(9377..9390)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.77"
                     /tool="antismash"
     misc_feature    complement(9379..9395)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.46"
                     /tool="antismash"
     misc_feature    complement(9441..9456)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 22.93"
                     /tool="antismash"
     misc_feature    9637..9650
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 25.85"
                     /tool="antismash"
     misc_feature    complement(9642..9655)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.15"
                     /tool="antismash"
     misc_feature    complement(9673..9688)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.67"
                     /tool="antismash"
     misc_feature    complement(9698..9707)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.04"
                     /tool="antismash"
     gene            10001..11422
                     /locus_tag="CPY53_RS15830"
                     /old_locus_tag="CPY53_15865"
     CDS             10001..11422
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) rSAM_pep_methan"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014279340.1"
                     /locus_tag="CPY53_RS15830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15865"
                     /product="radical SAM protein"
                     /protein_id="WP_017425690.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.7e-16,
                     bitscore: 58.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.4e-66, bitscore:
                     223.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 7.1e-12, bitscore: 44.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="rSAM_pep_methan (E-value: 2.1e-31,
                     bitscore: 107.2, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.8e-05, bitscore: 22.5,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 5.5e-15, bitscore: 54.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.2e-18, bitscore:
                     64.6, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.7e-05, bitscore: 22.3,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISAPFKKNPVKIIEQNEKLYLYNIKTNGLFQIDDVVVDICNSEG
                     KSIEEIYELLKYRSSREEIDRLLASLKEASVIYNKDLPIQKESKSCNDEQVSLSSIVLM
                     LVQECNLRCSYCYGGDGEYNDRGRMDTETALKAVDYLFNHSGEEEELNICFFGGEPLLN
                     IEVIKEVVAYTKLKLEKSNKRVTYSMTTNGTLISKEIENFLLDHHVSIQISLDGDQMTH
                     DFNRYYQNRKGTYEIILNRTESLRKKGAITARATISSVQLDITHTLTHLMGIGIRHVAM
                     YPAVEMLSEEDFEKYAQEFTKLVVHFESLLQAKKYGEARQISNILKYLQMIHSSSKRDY
                     FCGAVSHMLAVDVHGNLYPCQRFVNVKDYSLGNVREGMDVRKKSGMLSEMRLEKRTVCG
                     ECWAKNLCGGGCPQENMVLSGSINEPVDKYCNFTRSAIMDCMKLYLRLTKEDKTNLFSA
                     KQQREQLLEDASFDN"
     aSDomain        10025..10294
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CPY53_RS15830_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="9.70E-19"
                     /identifier="RREFam024.1"
                     /label="CPY53_RS15830"
                     /locus_tag="CPY53_RS15830"
                     /protein_end="98"
                     /protein_start="8"
                     /score="58.4"
                     /tool="antismash"
                     /translation="NPVKIIEQNEKLYLYNIKTNGLFQIDDVVVDICNSEGKSIEEIYE
                     LLKYRSSREEIDRLLASLKEASVIYNKDLPIQKESKSCNDEQVSL"
     gene            11403..12290
                     /locus_tag="CPY53_RS15835"
                     /old_locus_tag="CPY53_15870"
     CDS             11403..12290
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014279341.1"
                     /locus_tag="CPY53_RS15835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15870"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_044788282.1"
                     /transl_table=11
                     /translation="MPHLTIDIQALSKSYGSHQVLNELHFHIDNGIFGLLGDNGAGKTT
                     LMKILATLLRFDRGKVEIFGHSLKKEPDAIRSLLGYLPQHFDFFPNVTILESMNYFAAL
                     KGIQGKHHIQEETSQRLIEVGLIDQVHKKIKHLSGGMKQRLGIAQAMLGQPKLLIVDEP
                     TVGLDPKERIAFRNLLQNYGEDRIILLSTHIVPDVSSTCDKLLVLKEGRCLYQGAIDDM
                     IRTVEGKVWLVDVGKRQLEQLNQQARITSIVRKEGRIQARLLCNYPPDCCTEVTPETAN
                     LEDAYLYISDSEES"
     gene            12295..12984
                     /locus_tag="CPY53_RS15840"
                     /old_locus_tag="CPY53_15875"
     CDS             12295..12984
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014279342.1"
                     /locus_tag="CPY53_RS15840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15875"
                     /product="hypothetical protein"
                     /protein_id="WP_017425692.1"
                     /transl_table=11
                     /translation="MGQVTRALVQFEVLLMKKSVVFFIALTFSCFLIPLFLYLGAGNKN
                     NELWIFLHHGQMFFTILLMPLMYSVLYDSEKQKMISSVIMPKLLKGAQYFYCKSCVLWG
                     VVCLFQFVALAMIGVVQWTTHSKAPFLILLQLTAAGVATMGYSVQITVILNLVLRKQLY
                     VNIVMLVYLLISITINFPYISIWFNPDWIISNFFTQSFSFGRVFLFLLIWVLMKVSNHL
                     WMARVQG"
     gene            12981..14126
                     /locus_tag="CPY53_RS15845"
                     /old_locus_tag="CPY53_15880"
     CDS             12981..14126
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013368992.1"
                     /locus_tag="CPY53_RS15845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15880"
                     /product="hypothetical protein"
                     /protein_id="WP_038978230.1"
                     /transl_table=11
                     /translation="MNGIIVRFWLQLLFRREQAVTLLVSFSVVLLFNLIMNEGIAITYS
                     VNLLFVAFFSLQIASIHNRNHTEPYIYISVFPNYRLIAYQLYVSLILSFPLLLMMVGLL
                     WKSFADVSLWNLVLIVFFSSVFSSMLGLFLGQVVKHYGLAFTFLIAFYLPIGLVSWSFN
                     EKLRYISPIVNIFNPYMVNWRNLFGLLGCSLLFYGLGTMLSSRRGGGKKSIIPWISTVL
                     ACSILMGVWGYERLFNENVQTSSFQKITVGQTQVEYKGISLYQARQFATLFETLYQVAK
                     KNGTHPVRYTLEITRIHSMSSFEPKIIVQNHNKLQINIYSNKLLEFNFGMDWASKWIDY
                     ILPQSTHFSNEQVDAFRRVKSNIIVEVRRKNPGSVYTIQGD"
     misc_feature    14932..14949
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 24.35"
                     /tool="antismash"
     gene            15342..>15695
                     /locus_tag="CPY53_RS15850"
                     /pseudo=""
     CDS             15342..>15695
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="CPY53_RS15850"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKRGEPLALVGRNGSGKTTVIKLLTGLYEDFEGDILINSISIRNY
                     NKEMLYKKVGVIFQDFVQFDFSVRENIGFGSIGDLELDTRIWESAQHTGVDSVIRDLPN
                     QLEQQLGRNFEGGI"
     gene            complement(15653..16504)
                     /gene="phnE"
                     /locus_tag="CPY53_RS15855"
                     /old_locus_tag="CPY53_15890"
     CDS             complement(15653..16504)
                     /EC_number="7.3.2.2"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015416 - ABC-type phosphonate transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015716 - organic phosphonate transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="phnE"
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016324733.1"
                     /locus_tag="CPY53_RS15855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15890"
                     /product="phosphonate ABC transporter, permease protein
                     PhnE"
                     /protein_id="WP_242210433.1"
                     /transl_table=11
                     /translation="MKPDSTAQPLSSTQSSPSAGPPQPSKPPAGPPLPGRYKRYATWMI
                     FIVVLIACSIHTDATPYQLIVGLPEMGKLLEEMFPPDWSYLPIIWKPMLETIQIAIVGT
                     TLGAILAIPVALLCAYNVMPRKLISLPMRTILNLVRTIPDLLFASIFVAVFGIGPFAGM
                     LALLFFSFGIIAKLTFEAIEAIDPGPLEAMTAVGASRIQVIAFGVVPQALPYFVSYLLY
                     TFEVNVRAASVLGLVGAGGIGLLLDRSLGLFRYDRDIAIFCHCPPESCIPPSKFLPSCC
                     SN"
     gene            complement(16501..17271)
                     /gene="phnC"
                     /locus_tag="CPY53_RS15860"
                     /old_locus_tag="CPY53_15895"
     CDS             complement(16501..17271)
                     /EC_number="7.3.2.2"
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0015416 - ABC-type phosphonate transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015716 - organic phosphonate transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="phnC"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020723499.1"
                     /locus_tag="CPY53_RS15860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15895"
                     /product="phosphonate ABC transporter ATP-binding protein"
                     /protein_id="WP_023990372.1"
                     /transl_table=11
                     /translation="MIEFRNVSKTYPNGTKGLNNINLTIQEGEMVVIVGLSGAGKSTLL
                     RSINRLHDITSGDIVVGGRSVTSAGSSELRRIRRDIGMIFQSFNLVKRSTVLRNVLSGR
                     VGYHSTLRTILGLFPKEDIELALTALERVNIREKAYSRADELSGGQQQRVSIARALAQE
                     AKIILADEPVASLDPLTTRQVMDDLQRINREMQITTIVNLHFIDLAREYATRIIGLRAG
                     EVVFDGTPEEATDEAFAEIYGRAIKHDELLGVGS"
     gene            complement(17373..18341)
                     /locus_tag="CPY53_RS15865"
                     /old_locus_tag="CPY53_15900"
     CDS             complement(17373..18341)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010344588.1"
                     /locus_tag="CPY53_RS15865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15900"
                     /product="phosphate/phosphite/phosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_019688653.1"
                     /transl_table=11
                     /translation="MFKKALTLCMTFTLAAGLAACGSNASNNNSASTPGTDGSKNESTA
                     YVPKELKVQFVPSQNADTLEAKAKPLEKLLGDKLGIPVKVTVSPDYNTIVEAMSSKQVD
                     VGFLPPNAYVLAHDNRKAADLLLQAQRYGIEDATGKDTTEKVNFYKAMIVVKKDSPIQS
                     LADLKGKKVGWQNVTSSAGYVYPAAELKKAGVDPDTDVQGVTIKGHDAAILALLNGQVD
                     AVAVFQDARNTVKKEIPDVFEKTRVIHYTAKIPNDTVSVRSDMDQTWRDKIAQAFMDIA
                     NDPEGGEIIKEIYTHVGYEKGDDKNFDSVREYAEAVGQAVK"
     misc_feature    complement(18524..18541)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.54"
                     /tool="antismash"
     gene            18596..20503
                     /locus_tag="CPY53_RS15870"
                     /old_locus_tag="CPY53_15905"
     CDS             18596..20503
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0008663 - 2',3'-cyclic-nucleotide
                     2'-phosphodiesterase activity [Evidence IEA]"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /GO_process="GO:0009166 - nucleotide catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017425564.1"
                     /locus_tag="CPY53_RS15870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_15905"
                     /product="bifunctional 2',3'-cyclic-nucleotide
                     2'-phosphodiesterase/3'-nucleotidase"
                     /protein_id="WP_242210434.1"
                     /transl_table=11
                     /translation="MDNLDINDKTEQENAGAVRAKFRIMVTTDLHVSLWNYDYYTDQET
                     LHYGLAQTASLIHTARAEVPNHLLLDNGDVIQGNPMGDYAVQRLQQDPSEVHPAYKAMN
                     LLGYEAGSIGNHEFNYGLEYLQTCLQGAQFPYVNANIYIAGEEEENYFTPYLLLDKTVE
                     DEAGRKHLLKVGVIGFVPPQIMQWDKAWLEGKLIVKDMLETARRFIPEMQAQGADLIIA
                     MPHAGFEDIPEIPNMENAVLHLSRVEGIDAIVFGHAHKVFPGPSFIGMTGVDTEQGTIH
                     GIPAVEPGFWGDHLGIIDLDLALIGGKWQVTASAAEVRPVYDPIRKEALVQPDTAIQQA
                     VAAEHAGTLDYIRAPAGQTTVAVNSFFAQVMDDASVQLVNDAQIWYVKQQLQGSEYEGL
                     PVLSAAAPFKTGGRYGPAYYTDIPAGTLAIKHIADLYNFPNTLHVVRLSGAEIREWLEW
                     SAGQFRQIDPLAKEEQELINSDFPSFNFDIIDGITYQIDVTQPARYDTHGELKDLEAHR
                     IVHMSFEGEPMDMQRSYLVVTNNYRAFSSALVNPGGERIILASPDENRHVLTEYVRHME
                     TLTPKADGHWSLAPWSGRPHVTFLTSPQATNVAHAYSELLYEGLTAEGYAKFALDFRQF
                     "
ORIGIN
        1 tcctttgttg cctatacctg attttgctta tgcatcattc gatttataaa ataatctcca
       61 gacggtgtac accatcatgt tctgctaacg cctgctcgaa agtctcacgt ttgatgcgca
      121 aggcaccgga acgatagcga ttatcatcgg ctggctcact ttccagaggg gcaccgttca
      181 atactgcacg gccttgctca ccgctcgtat gctcttgcag catgcggtag acgaaggtga
      241 ttggctttcc tgcaaaggaa aatttaaatt ccaatccgtc gagatcgttc ggcagcacag
      301 ggtccaggat caggtcctcg cctgactgac gaataccaag gacattcgat atgagctgat
      361 tcatgtagat tcccggaccg ctggaataga ttctccagcc acccttgacg ggtacggctc
      421 cttcccgcag ttcatcaaac cgttcctgtg cttcatagcg ggtgttaaat ttaccgtccg
      481 agctgctgaa atacgcgttg ctttggcgcc attcggcatt cggtacggtc gcgcggatgc
      541 cgaccggatt gatgagcttc aggctgtgcc aagcgtcatc cttgcgtcct aacttggcca
      601 tggcttccac aaagcggata tgagcgtgca catattgcag ccccacctca cgtccaaagt
      661 tggccgcttg ctctgcgcgc ttgaagtgcg aactcacacc gccatcatat tgagcagggc
      721 ggttcatcag acgcacacca tccgggcaga ggaactgctc gcggatgagc tgctcatgag
      781 ccaatgcttg ctcaggcgtg agcaactggc tgatcatgct gcgtgtcatc ggcagcaaac
      841 ggtagtggat tcccgtctcg gtgtcggacg gatggagcat gagcttgggt tgaccaggct
      901 cttccatata tacaaagcct ggaataattc cgctctccag catgtagcga ttgaagtctt
      961 tacggatgcc gttcgccatc tgatgtaaat cttgtgcaat tttatccgct tcgcttacta
     1021 catttgctgg agcttgctcc aacacagcag caaagttacg aatcacttgg taggtgagtg
     1081 caaccgtcca gctgctcgcc atgtattgct tcagttgcgc attggctggc tggagggtgt
     1141 catcccaatc gccatcgcca taagccgata agtacgtatc atgcaggaaa ttctctcgaa
     1201 tatattcgat ttccttcagg gcatgttcca taagggtcgc agtctgcttg gtataatcga
     1261 aagtatgccg atgggtgtaa ggcacatttt ctcccagaat actgtaatca cgggtagcgg
     1321 tcaaataatc gcccagtacc ttgagcggcc aaacgataat atccccatgg ctttcttctt
     1381 gctgcacgtg agtatagttg tcaaacataa accattgcgg ccagtttccg ctgtcttcat
     1441 actgatggct gaatacagtt agcaaaatgg aacgaacctc atcaaaattt tgcactgccg
     1501 aaaaatattc gacaggcccc tgacatacat cacgtgttcc ccaggctgct ccgccgtatt
     1561 gctccagacc gtgaggcaca gagtagtgga cgagcatgtt gtgggtgtac caccaggcca
     1621 ctgcgttcac acggaatagc tcgctggttt cctgttggcc aagcgtcaga tggaagccat
     1681 tcataagctc ggcaaaatac tcccggtagc gctcgcgctc atcttcaaag gaggcgtgta
     1741 gctccttgtg tgctcggtcc ttcccggtcg agcggccatg cagccagccc tgtacaatgc
     1801 aggtccattc gctgctgtcg cccagttcca aaacgaccag ggatgcatca ggagaggctc
     1861 caccctgtag cagtgcttga gcgtcgctca catgctgtaa tggagcgccc tctacgtgca
     1921 ttcggtaaag caggtcggga taggcctcgg cgctcaggga agcggaatca gctctaaaga
     1981 gcaggtcatc accttcgcgt tccatatgaa acggaagctc atattcgttc acatgcatac
     2041 acatttgctg agtgatcagg aatggatagg ctttaccact tgccgagcgc atgtgaagcc
     2101 gcacttctgg gctatcagca ttcgtatggt ttgtaataat gaatgtatcg tcagccgttt
     2161 tgtaatacca gcgcacataa ttaaagccaa tctcaaacag ggaaggcatg gtgagcaggc
     2221 gatattttcc ttgaattccg acgtagatac gttgaccgga tgtcttggga atgttgagcg
     2281 cattacgcac gttggtgatc attttgttga aattcgtatt gccgatcacg agctgggaat
     2341 tgaatacccc gtacatatag gaagtggttg taatggtttc ttccttacct ccagagtaat
     2401 gcccacccat taaaatgtgt ccgtgaggac gctctacacg aagctctttg gatttgagta
     2461 cgacatgctc atagctatcc gtgaaaaagg aaagtagtgt atcgccatcc cgttcttctt
     2521 cctggcgttt cgggaaaagc tgattcactt cggcatcggt caagtccagt gtgcgcagcg
     2581 gttcgccgat ggtttgagct ggggccacac gccctgcctg aagatcactt gccgcgtgtg
     2641 ctggtatgct ggtctcagaa gcgtccgcta gaacggtagc tacttcatcg cgtgctttgg
     2701 ttaccaggtc ctgatactcc agcttcgtca ctgcagccgg atggctcggc tggaacagac
     2761 cgtaaaacgt aaagcgagct tccccagcga gttttacccg ctcagattgc agcgccgtat
     2821 aagcgaattc gtattgatat acttcattgg cgagcgtgtc gcggcgcagt gcttccggct
     2881 cattcgtttc cttgtaagaa agtccaaaga actgaaatcc gtctgtcgag taaccaacag
     2941 tgcgggttaa cgagccttgt tgaatgtatg ggaatgcctg actttgaggc tggttttgac
     3001 gtgagcaaac ggtatagcct ctttgttcat catgatagac agtatggtca atatattgag
     3061 acaaatatgc ttcattactg cgcacagcag cggtatcggc aatgccgata tcctgaccgt
     3121 acacaatatc tgcttcaaca tcatcgccct gtagggttac atcccagaac catactccca
     3181 ggcggctgag tgtgaaggtc acctgatagc ctacaccggc agtgaaccct tcccatataa
     3241 tctgctgatc cgtttgtcgg attacgccgg gcgaacgaac tcccagcaga ggagtgatgc
     3301 ttacgccgga aggacgatac agtctcaagt acagattgtt cagggaacca tcgactgaat
     3361 tggtcaacag ttggttgatc atcgttgagc cgtgagcgat cttgtacaca tcaccgctgc
     3421 ttaagaaggt aaaagacagg tctccggccc gcagcaaaat attttggtct agacttgtat
     3481 tcatcaaagg gaacgcctca ctttcctgtt tcttttacta accgaaaacg gccttcagta
     3541 gtatctcggc tgttaggtcc tgtaaagacg gcgaattcac cgctgtcact gtcaaagctc
     3601 aaatctgcat gatgataccg cagctgaggc tcggtcactg taaactccac ttcccggttt
     3661 tcgcctgggg caagcaggat tttgcagaaa tctttcagtt ccttcatggg gcgaaccgta
     3721 tcaccgctga tatcacggac atagaactga acggtctcct cgactggacg tgttcctgtg
     3781 ttcgttacct gcactctaac ggtcagttct tgaccgggaa taagagtatc gcctgaaagt
     3841 tgtaagctgt cataggctac atcggtgtag ctcaggccat agccgaacgg gaataaaggt
     3901 tcgttcggta cgtctagata ttgagacacg tagcgttctg ttgtgttcgg atctaactgc
     3961 ggacgtccag tattaaaatg attgtaatac actggcacct gtccgaccga ttgcgggaag
     4021 gacatcgtca gacgacccgt aggttcagca tcaccgtata acaaatcggc aattgccgcg
     4081 ccgccttcgc caccagggaa ccaggcttcc agtacagcgt ctgcttcttc aatgacgccg
     4141 tgcagatcca atggacgacc attaaacagt acggctacca tgggcttgtt cagtgtcttc
     4201 aggcgtttca ccaattccaa ttgagcctgc ggcaggcgaa tatttgaacg gctgcctgct
     4261 tcaccactca tatctgagcg ctcgccaagc gctagtacga tgatctctgc ttgactggca
     4321 gcatgcagag cttctgcata ttgctcctct gttatgttgt ctacagagca tcctgccgct
     4381 accgtgagca gcgaggagga tattttcgat tggaatccat caacaacacg aatggcttcc
     4441 tcttgtgaac cgctccatga ccaagagccc agaatatcgc cgctctctgc aaaaggtccg
     4501 atcaatgcaa tatgttgatt gcgattcaat ggaagcacag aatcattttt gagcagcacg
     4561 catgatttaa tggctagttc tttagcaacc gcacggtggg cttcacagaa taccacttca
     4621 cgttcacgct cagggtctgc gccgcgtagc ggattctcga acaagcccag cttttgtttg
     4681 agcttcaata tacgcatcac tgcttcatca acgagcgctt catccagctg tccgctgcga
     4741 atcagctcag gcaggtaccc attgtagcag gaggtcatca tttcaatatc tacgcctgcc
     4801 agcaatgctt tttttgctgc ctcccgttca tcctcggcga tgccgtgagg aataagctct
     4861 ttgatcgcgg cccaatccga aatgagtaca ccgtcaaaac cccattcatc acgaagcaga
     4921 tcacgcatca ggcgcttgtt gcccgttgcc gctacgcctt ctacggtatt gaaggacgtc
     4981 atcaccattt cgcagccttc atctaaagca gctttgtagg aagggagata atactctcgc
     5041 agctgccatg cagatacatc tacggtattg taatcacgtc cgccttcacc ggctccataa
     5101 gcagcaaagt gcttcacgca tgcggctacc cgctcggtat cattcgtcag atcattaccc
     5161 tgaaatccgc gcacaaacgc acgggcaaat tgactgttga gataagggtc ttccccagta
     5221 gattccatta cacgacccca gcgtgggtca cgtaccagat cgaccatagg agcgaatgtg
     5281 acgtgaacac cggatacggc tgcttcccga gcagcgatag tagcgctctc ttctgcaagt
     5341 tccatatccc atgagcaacc catagccagt ggtataggga aaatcgtttt gaagccgtgt
     5401 acaatatctg ccataattaa aagcgggata cccagacggt ttttactcaa atgagcctgc
     5461 tgaacacgaa ttgcttcctg ggctcctgca aggccgagca cggaaccaac gttgtgaacc
     5521 gtttgctctg tgatgccgag agaagccata ggcccagtaa tttggccctc tgtacccgct
     5581 tcttcaaaaa agccacccac aagctgaagc agttggtcaa ctttttcttc aagagtcatg
     5641 ttttgtaaat aggaattcag gtgttgttcc atcataatcc tccgtaagct gtatggttgg
     5701 taaaacagct ctctttttca gattcatgag attttttgga taaagttgat tcaaaaaagt
     5761 gctgaacagg ctaatagcta gtatagaagc ataatcttct gttgtattat taatcgaaac
     5821 gtttctattg ttggactcag ttggattata tacgcttcca aatagagagt caaatgcaaa
     5881 acgggggttt tttataggac aaatagcgta ataaagattg aaataaatga aaaagaggtg
     5941 cgattccaag taaataaaaa ataatatccc tattgaatac ggtttcaatt tgttctataa
     6001 tgactatcga aacgtttcta ttgatgagta tggtccttag gctttaaaca taattgttat
     6061 aacggtatgc tttaactgct atgtatttgc atgtatcagg attttgcaaa attcgatttc
     6121 agtcgctcca aattgcaata tttggacatt ggaagtcgct tattgaattt ttgcaaaatt
     6181 catgtgcttg aatccgttat catattgcat gatcggtaaa ctgatcatct cgggaggaat
     6241 tcgtatgatg aaaagaacat tggggatcat tttggcaagc accttattac tggggggtgc
     6301 gttggtaggc tgttcatcca aggatgattc gtcgggcaaa gatgcaaatg gcaagacgac
     6361 catcaccatg tggggaatgg gagcggaagg gaagttgctg cctgaaattg taaaagattt
     6421 tgaaaaagaa aatccagata ttcacgttga tgtacaggcg ttgccttggg ataacgctca
     6481 cgacaaattg ctcacggcgg ttgcctcaaa atcaggtcca gatgttgtcc agctcggtac
     6541 atcatgggtg ccggaattag catctgcggg tgcactaaca gacatcacgc cttacatcag
     6601 caaataccct gagcttgaag cgaaaaattt cttcaagggc gctgtgagta cggctcaatt
     6661 tgaagctaaa ccggtcgccg taccttggta cactgaaacg cgagttttat tctatcgttc
     6721 ggacctactg aaacaggttg gatacaatga agcacctaaa acgtgggagg aactgtccga
     6781 tgctgctcaa aaactagcgg ctcggggtaa aggcaaatat ggtatctcct ttagtgcaaa
     6841 ggagcagtcc atgggcttta tgtttgctct ccagaacggt tccaagctgg ttgacgagca
     6901 gggcaatccg ctattcaacc aagcaccgtt tgtagatgct gtgaagtatg taaatacctt
     6961 tttccaaaat ggctctaacg cagtggatat tggaattgat tccgttcaag gtttgcaagg
     7021 cgaggggatc gttccaatgt ttatcagcgg tcctttcatg attaaagaaa tcaagagcaa
     7081 ggcaccagaa ctggaaggca agtggaatat tgcggagctt cctggcaaag taaacaacct
     7141 atccgttttg ggtggagcta acctttcaat tatgaaattc agcaagcacc cagaggagtc
     7201 ggccaaattc ctggcttaca tgagcaaacc agaaacacaa ctgaaatgga tggagctgtc
     7261 cagtaacttg cctgcgacta ctaaatcgtg ggaagatgcc aaactgaaga gtgatccgat
     7321 gcttctgacg attcgcaaac agctggatca ttccgcagca ttgccgcaac tggctgcatg
     7381 ggaagaggtt tctcaacaat tcatcaagag ctttgagcgt atttaccgcg gtcatgccga
     7441 tgtacagaag gaaatggatg actttaatca gcaggctaca agtataatga aaaaataatg
     7501 atccatatcc gtcattgtca aagggagtga aggcatgaaa ggaagctcgc agaagcttgc
     7561 gccatacttg tttatcggtc cctccatcat cctgttaacg ctgttttcgt tattgccgat
     7621 actactggcg ctcgtgatca gcttcacgga tatggatctg tccggactcg ttaattatga
     7681 aagtattcgc tttataggat tggaaaatta cacgaacgtg cttttggacc cttccttttt
     7741 gaagtccatt gggaatacgt tgttctttgt tatcattggc gttccgctgg tgctgatatt
     7801 ttcactcagc atcgcgattc tgattaacat gggtaaatca cgtgctttca aagtattccg
     7861 cgtcgtgttc tatctgccgt ccgtaacgaa tgtggttgcg gtcgcagtgg tttggagcta
     7921 tctgtataat ccgacgcttg ggttattcaa ctacgtactt ggtctggtga atttaggtcc
     7981 cgtcccatgg ctgaccgatc caacagtagc gaaaatttcg ctgattgtgt tagcggtttg
     8041 gcggggcatc ggtttaaaca tgattatttt tattgcggct attaaaggca ttccaggctc
     8101 ttattatgaa gcggcccagc ttgacggggc caatacatgg cagcaaattc gttatattac
     8161 gctgccgcag cttcgttacg ctattttctt cgtgtccatc acgacgatga tcggctggct
     8221 gcaatttttc gaggaacctt ttgtcatgac caaagggaaa ccgctggacg gtacgctgac
     8281 ggcatccttg ttcatttaca ataacggctt ccaatttagt aaattcgggt atgccgcggc
     8341 gggatcgttc attctgttct tcgcgatcat cgcggtaacg ctgattcagt tccgtttgca
     8401 aaataaagcg gagtcctgat agagagaggt gatgagcgtg aaaacagctg ttcagcaagc
     8461 ccgcgccaat acgcgcagtg gtgaaaaaac atttcaatgg ttcgtggcga ttctcctgac
     8521 tgtgggaggt ctgttgatgg tgctgccttt tgcgtggatg attttatcct cctttaagac
     8581 agagggcgag gtaaccaaaa ttcctccaac catctggccg gagcatttta cactggataa
     8641 ttttaaaatc ctattcgata gcatggcgtt tggaacctac ctgacgaata cgctgatcat
     8701 tgtcctagct tccttcttcg gattattcct taacgctatg gcgggttatg gttttgccaa
     8761 atttcagttt aagggcaaag gtttcctgtt ctatctggtg ctggcaacca tgatgattcc
     8821 aggtcaagtg acgatgattc ccgtctattt gattctaaac cagatggggt tgaccaattc
     8881 catgctgggg attgtgcttc ctggattggt gggcgcgttc gcgatcttcc tcttccggca
     8941 gttcatgtcc gatatcccgg aagaactgct ggaggcgaca cgacttgatg gagcagggga
     9001 gttccgcact tttttacaaa tcgtgctgcc catttcgacg ccgattattg cggtacaggc
     9061 gatcctgacc ttcatcggtg gatggaacag cttcttatgg ccgctcatta ttgcgaacga
     9121 tgagaagctg tacaccttgt ccgtaggttt atcactgctc aagggacaga acgaaagtca
     9181 atttgccctg caaatggcgg gttcgacctt tatggtcgtt ccgattatga ttatcttcat
     9241 tattttccaa aagtatatta tcgagaatta tacaatttcg ggaattaagt aggggtataa
     9301 taggtatgta aaatgataaa aacacaaaaa cggaggactt cttagaaaaa gaagccctcc
     9361 gttttttgtg atcttgtttt atagaaaaat tagaaaacct ggctagtcac attcatttct
     9421 aagaggctgc atcaggtttt gtttatatat gaaaacggga gaacgaagat ttagaattca
     9481 aagattgcgt gttacgaagg tgaataaaag ttccgacctc tagaatcttt aagacatgca
     9541 ttacataaac aacgaatagt ttttttggca aagaaaatta tacttttatt atatttaatt
     9601 gaatatattt caaaaataat atgttaacaa attttatata attattttaa aaaaagtatt
     9661 gaagtgcaat aggaaaatga ttatcttgga aatgaaataa aaaaatacaa aaaaatgggg
     9721 tgattcaaat tgttcgatcc tattaaccaa gcagctgaag gaagtgtttc ccctatgacg
     9781 tgtgttcttt gtgatacacg tgatcgttgt gtaggttgtg atgctaccga ttggttttgt
     9841 agcaaagaaa gtggtcattg gtgtactaat aatgatagcg attaattgaa gtaaagctcg
     9901 caacgatagg actttcaaac acaggtagtc aattaggagg tctgggaact aatcttcttg
     9961 gacttccccc tattttgtaa ctttgagagg atgatcaata gtgattagtg ctccatttaa
    10021 aaaaaatccc gtcaaaatca tagaacaaaa tgaaaagtta tacttataca atataaaaac
    10081 aaatgggctt tttcagattg atgatgtcgt agtagatata tgtaatagcg aaggtaagag
    10141 cattgaagaa atatatgaat tacttaaata tcgttctagt agagaagaga tagataggtt
    10201 attagccagt ctgaaggaag catcggttat atataataaa gatttgccta ttcaaaagga
    10261 atctaaaagt tgcaatgatg agcaagtaag tctatcgtct atagtcctta tgctggttca
    10321 agagtgtaat ctaagatgct cttactgtta tggaggagac ggagagtata atgatcgagg
    10381 gaggatggac acagagaccg cattaaaagc agttgattat ctgtttaatc attctggcga
    10441 agaagaagaa ctgaatattt gcttttttgg aggggagcca cttctgaaca ttgaagttat
    10501 taaagaagtt gtagcctaca ctaagctaaa actagaaaaa tcaaataaac gtgttacata
    10561 tagtatgaca acgaacggta ccttgatttc caaagaaatt gaaaactttt tattagatca
    10621 tcatgtttct attcagataa gtctagacgg tgatcaaatg acgcacgatt tcaatcgata
    10681 ttatcagaac agaaaaggta cctatgaaat cattttaaat agaacagaaa gtttaagaaa
    10741 aaagggtgcc ataacagcaa gagctacgat ttcatcagta caattggata taacacatac
    10801 acttacacat ttaatgggga ttggtatccg ccatgttgcg atgtatcctg cagttgagat
    10861 gcttagtgag gaagactttg agaagtatgc acaagaattc accaaattgg ttgttcattt
    10921 tgaatctttg cttcaggcca aaaaatatgg ggaagcacgt caaatatcga acattctaaa
    10981 atatttgcag atgattcatt cttcttctaa gcgagattat ttttgtggag cagtctcgca
    11041 tatgcttgcc gttgatgtgc acggtaatct ttatccctgt caacgatttg ttaatgtaaa
    11101 ggattattct ttagggaatg tgagggaagg gatggatgta agaaagaaga gtggcatgct
    11161 tagtgagatg cgtttagaga agagaactgt atgcggagaa tgttgggcta agaatctatg
    11221 tggtggaggt tgtcctcaag aaaatatggt gcttagcggt tcgattaatg agccagtgga
    11281 taaatactgt aactttactc gtagtgcaat aatggattgt atgaagttgt atttacgatt
    11341 aactaaagaa gacaagacaa acctgttctc agctaagcag cagcgagagc aactattgga
    11401 ggatgcctca tttgacaatt gatattcaag ctttaagtaa gtcgtatggt tctcaccaag
    11461 tacttaacga gcttcatttt cacattgata atggtatatt cggactgctt ggagacaatg
    11521 gggcgggtaa gaccacttta atgaaaattc ttgccacttt acttagattc gaccgaggga
    11581 aagttgaaat attcggacat tctttgaaaa aagaacctga tgctattcgt tctttactgg
    11641 gttacttgcc gcagcatttt gatttctttc caaatgtgac tattttggaa tccatgaact
    11701 attttgcagc tttaaaaggt attcaaggta aacatcatat tcaagaggag acatcacagc
    11761 gattaattga ggtaggactt atcgatcaag ttcataaaaa aataaaacat ttgtctgggg
    11821 gaatgaagca gcgcttagga attgctcaag ctatgttagg acagcctaag ttgttaattg
    11881 tagatgagcc tacggttgga ctggacccca aagaacgaat tgcttttcga aacttgcttc
    11941 agaattatgg agaagaccgg attatattgt tatctactca tattgtccct gacgtttcaa
    12001 gcacatgtga caaactactc gttttaaaag aaggtcgttg tctgtaccaa ggggctatag
    12061 acgatatgat tcgaactgtt gagggtaaag tatggttggt tgatgttggc aagcgtcaat
    12121 tggaacaatt aaaccaacaa gctcgaatca cttccattgt gcgaaaggaa ggaagaattc
    12181 aggctcgatt attgtgtaac taccctccag attgttgtac agaagtcaca cctgaaacgg
    12241 ctaatcttga ggatgcgtat ctgtacattt ctgattcgga ggagagttag cagaatggga
    12301 caagtaacca gagccctagt tcaatttgaa gttttgctta tgaaaaaaag tgtagtgttt
    12361 tttatagcac taacgttctc ttgtttttta attcctttat ttttatatct aggagcaggg
    12421 aataagaata atgagttatg gatatttttg catcatggac aaatgttctt taccatatta
    12481 ctaatgccgt taatgtattc tgttctttat gatagtgaga agcaaaaaat gatctcttct
    12541 gttattatgc ctaaattact taaaggagcc caatattttt attgtaagag ctgtgtatta
    12601 tggggagtgg tttgcttatt tcaatttgtc gctttagcta tgattggtgt agttcaatgg
    12661 acgactcata gtaaggctcc attcttgata ctgcttcagc taacagcagc aggtgtagca
    12721 actatggggt attctgttca aattaccgtc atattgaact tggtcttacg taaacaactg
    12781 tatgtgaaca ttgtgatgct cgtttacctt ctaatcagta ttactatcaa ctttccttac
    12841 atttcaatct ggtttaatcc ggattggatt atttccaatt tcttcacaca gtcgttttct
    12901 tttgggcgag tattcctatt tttgcttata tgggtattga tgaaagtcag taatcatcta
    12961 tggatggcga gggtacaagg atgaatggaa ttatagttcg tttctggcta cagcttttat
    13021 ttcgaagaga acaagcagta accttgctcg tttcctttag tgtggttctt ttattcaatt
    13081 taataatgaa tgaaggtatt gcaataactt atagtgttaa cttgttattt gtagcttttt
    13141 tttctttaca gattgcgagt atacacaatc gtaatcatac agaaccgtat atatatattt
    13201 ctgtctttcc taattaccgt ctaatcgctt accagcttta tgtttcttta attctttcgt
    13261 ttcctctctt gctcatgatg gtaggacttt tatggaaatc attcgctgat gtttcactat
    13321 ggaatttggt tctcattgta tttttttcta gtgttttttc atcgatgttg ggtctcttcc
    13381 tggggcaggt agtaaagcat tatgggttag cctttacttt tctcattgct ttttaccttc
    13441 ctataggttt agtttcctgg tcttttaatg aaaagttacg ttacatatct cctatagtga
    13501 atatattcaa cccctatatg gtcaactggc gaaatctttt tggactctta ggctgtagtt
    13561 tattatttta cggattaggc acaatgttat ccagtcggcg tggaggcggc aaaaagtcta
    13621 taatcccttg gattagtaca gtccttgctt gtagtatatt gatgggcgta tggggatatg
    13681 agaggctatt taatgagaat gtacagacat cgtcgtttca aaaaataact gtggggcaaa
    13741 cacaagtaga gtataaggga attagtttgt atcaggcgag gcaatttgcc acccttttcg
    13801 aaacgctgta tcaagtggct aagaaaaatg ggacacaccc ggttcgctat accttggaaa
    13861 tcacccgaat acactccatg tcatcgttcg agccgaaaat aatagttcaa aatcataata
    13921 aacttcaaat caatatttat tcaaataagc ttttagagtt taatttcgga atggattggg
    13981 cgagtaagtg gattgattac attttgccgc aatcaactca cttctccaat gagcaagtgg
    14041 acgcatttag gcgcgtcaaa agtaatatta ttgtggaagt tcgcagaaaa aatcctggaa
    14101 gtgtctatac aattcaggga gattgaaagc tgaaataacg agaattcgtg aagaaccaat
    14161 aatagtggat ataaaagaaa gggatggaat gaatggaacg tgaggtagac catttgaata
    14221 taagagctat atttcagtca ttccaatatt ggccgaaatt aactaggttg ttatggaata
    14281 caaaacctat ctattttatt atcatcatca ttggttatct tttaaaagga atactcccga
    14341 ttgccaatct cctttccata cagtatttgg tttctgaaat agaaacaaga ccattatcgc
    14401 atatgcttca aataagcaca gtgtaccctt tagttcttgt gatgttttgt ggtctgctca
    14461 tttcaagttt aattgaatat tctgataaac tgttccaaat tactctgata aaccaattac
    14521 aaacattgat agtacaacaa acatcaaaat ttaatctttc ggattttgaa aacccgcaag
    14581 tacataatca gctcaaaaga gttcagaacg actcgataga tagacctatc cagatctata
    14641 aagaactcat taatttgtta agttccatgg ttacactatg ctctagtatt gccattttac
    14701 tagcgttcag atggtggatt ttacttattc tcattctttc tcccctagca tccttttatt
    14761 ctttactgag gttcacacaa attcagtata tagctaaaaa gaaacgtgct cctttacaac
    14821 gcaaatctag gtatattaat tatttgctca ctaatgacaa gtcttttaaa gaaatcgtat
    14881 tgtatcaact tagtgactat ttaacggcaa gatataagag catttttgat gttttctata
    14941 aagaggataa gcatttagcc aaaaaacgta tcactttata cttatcattt caagtgataa
    15001 gtacattagt tatagccata gctttgatca tgattataca aataacatgg aaagaaaaat
    15061 tacttgttgg cagtgtttat gcattagttc aagcagtatt attaactaat caaaatatta
    15121 acacggtatc tcaaggattg atttcattgt gtgatcataa tctgtatctg gatgaattat
    15181 tcgctttttt taacataaaa gaaaaacaag agaattctag tatgttacta agagaatcag
    15241 gtatatgtgt tgattcaaca atagaatgca tagaatttaa aaatgtttca tttgcctacc
    15301 cagatcaaaa agaattagct ctcaaagata taagttttaa aatgaagcgt ggtgaacctc
    15361 ttgctctagt gggcaggaat ggatcaggga aaacaacagt gataaaactt ttaacggggt
    15421 tatatgaaga ctttgaagga gatattttaa tcaattctat ctcgattcga aattacaata
    15481 aagaaatgct ttacaagaaa gtaggtgtta tatttcaaga ttttgtccaa tttgattttt
    15541 cagtaagaga aaacataggt tttggcagta taggagatct tgaacttgat actaggatat
    15601 gggaatcggc acaacataca ggagtagatt cggtaatacg agatttgcct aatcaattag
    15661 aacaacagct aggaagaaac ttcgaagggg gtatacagct ttcaggaggg cagtggcaaa
    15721 agatagctat atcgcggtca tatcggaaca gcccaaggga acggtcaagc agcagaccga
    15781 tgccgcccgc accgaccagt cctagaacag aagctgcgcg cacattaacc tcaaaggtgt
    15841 atagcaaata cgacacaaaa taaggcagtg cctgcggaac cacaccaaag gcgatgactt
    15901 gaatgcggct cgcgccaaca gcggtcatgg cctccagtgg cccgggatca atggcttcaa
    15961 tcgcctcaaa ggtcagcttg gctatgatcc cgaaggagaa gaacagcagg gcgagcatcc
    16021 ctgcaaacgg tccgatgccg aatacggcca caaagatcga ggcaaacagc aaatcgggaa
    16081 tcgtccgtac cagattcagg atcgtgcgca tcggcagcga gattagcttg cgcggcatca
    16141 cattataggc gcacagcaac gcgacaggga ttgccaatat ggctcccagt gtcgtaccga
    16201 caatagcgat ctggatcgtt tccagcatcg gtttccagat gataggcagg taactccagt
    16261 caggaggaaa catttcttcc agcaatttgc ccatctccgg taagccaacg atcaattggt
    16321 aaggcgtggc atccgtatga atggagcagg ctatcagcac cacgataaaa atcatccagg
    16381 tagcgtaacg cttataacgt cctggcaaag gtggccctgc aggcggcttg cttggctgcg
    16441 gtggtccagc agatggtgac gattgcgtcg aagagagcgg ctgggcagta gagtcgggtt
    16501 tcatgatccc actcccagca gttcatcatg cttgatggcc cggccgtaga tctccgcaaa
    16561 ggcttcatcc gtagcctcct ccggtgtgcc atcaaagacg acttctcccg cgcgtaatcc
    16621 gatgatccgt gttgcatatt cgcgcgccag atcaatgaaa tgcagattga caatggtcgt
    16681 aatctgcatt tcccggttga ttcgctggag atcgtccatc acctggcggg tggtcagcgg
    16741 atcaagcgac gcgacaggct cgtccgccag aatgatttta gcctcctgcg ccagagcacg
    16801 cgcgatggat acacgctgct gttggccacc ggacaattca tcggcgcggc tataggcctt
    16861 ttcgcggata ttcacgcgtt ccagcgccgt tagtgccagt tcgatgtctt ccttcgggaa
    16921 gagaccaaga atggtccgca gcgtcgaatg ataaccgacg cggcccgaga gtacgttgcg
    16981 aagcaccgtc gagcgcttaa ccagattgaa gctttgaaag atcatgccga tatcacggcg
    17041 aatgcgccgc agctcgctgc ttccagcaga cgtgacagac ctgccaccta caacgatgtc
    17101 gccggacgta atgtcatgca gtcggttaat ggaacgcagc agggtggact tacctgcacc
    17161 agataagccg actatgacaa ccatctctcc ctcctgaatc gtcaaattaa tattattcaa
    17221 ccctttggtg ccgttcgggt atgttttcga tacgtttcga aattcaatca tatgctccca
    17281 actttctccc cgatggggtg gaatgaaaac aacaccgcca tgaatacatg gacggtgctg
    17341 ccctgtcatt cgtaaagcct gtttcgtagc tgttacttta ccgcttggcc gacggcttcg
    17401 gcgtattcac gcacagaatc gaagttttta tcgtcgccct tctcataacc tacatgggtg
    17461 taaatttctt taatgatttc gccgccttca ggatcgttgg caatgtccat aaaggcttgg
    17521 gcgattttgt ctctccacgt ttgatccata tcggaacgta cgctgacggt gtcatttgga
    17581 attttagctg tgtaatgaat gacacgtgtc ttttcaaata cgtccgggat ttccttcttc
    17641 actgtgttac gtgcatcctg gaaaacagcg acagcatcaa cctgaccgtt cagcagcgcc
    17701 agaatagcag cgtcgtggcc tttgatcgtc acaccctgca catctgtgtc cgggtccacg
    17761 ccagcttttt tcagctctgc tgcggggtac acatagcctg cggaggaggt tacattttgc
    17821 cagccaacct tcttgccttt cagatcagcc agactttgaa tcggagaatc cttttttacc
    17881 acgatcattg ctttataaaa gtttactttt tcagtcgtgt ctttgcctgt ggcatcttca
    17941 atgccatagc gttgagcttg caggagcaag tcggccgctt tacggttatc gtgtgccagt
    18001 acataagcgt tcggcggaag gaatcctaca tcgacctgtt tggaagacat ggcttccaca
    18061 atcgtattgt aatcaggaga tacggttact tttaccggga ttccgagctt gtcccccagc
    18121 agtttttcga gcggttttgc cttggcttcg agggtatctg cattttgaga aggaacgaat
    18181 tgtaccttta gctccttagg gacataggct gtgctttcgt ttttagagcc atctgtaccc
    18241 ggagtggagg cgctgttgtt attgcttgca tttgagccac aagcggctaa acccgctgcc
    18301 agtgtgaagg tcatgcacaa ggtcagtgct tttttgaaca aaataatttc cccctaaaca
    18361 tcgtaataac gaaaatttaa aaaacctgta aattcagtga caaaccaaat cttaacagct
    18421 agtcttgcag ctagggtaaa aatcactcct gactttggta aaaatgatgt aaaatttatc
    18481 atttgctaga gaccataagc ggtatttata cgaattgcat attttaacat tctcttaaca
    18541 gtgctctgtt agacttgttc aagctctatg accgaagctg agggagagaa caagattgga
    18601 taatttggac attaatgata agacagagca ggaaaatgca ggtgctgtga gggcgaaatt
    18661 ccgcattatg gttacaaccg atctgcatgt cagcttgtgg aattatgatt attatacaga
    18721 tcaggaaacg ctgcattacg gtctggcgca aaccgctagt ctgattcaca cggctcgggc
    18781 agaggtgccc aatcacctgc tgctggataa cggagatgtg attcagggaa atccgatggg
    18841 agattatgct gtacagcggc tccaacagga cccaagcgag gtgcatcccg cctataaagc
    18901 catgaatctg ctggggtatg aggcaggcag tattggtaat catgaattta actatgggtt
    18961 ggaatatttg cagacttgcc ttcaaggagc acagtttcct tatgtgaatg ccaacattta
    19021 tatagcggga gaggaagaag aaaactactt cacgccttat ctattgctgg ataagacggt
    19081 tgaggatgaa gcaggccgta agcatctgct gaaggtgggg gtcatcggct ttgtgccccc
    19141 gcaaattatg caatgggaca aggcgtggtt ggaagggaaa cttatcgtca aagatatgct
    19201 ggaaaccgcc agacggttta ttccggaaat gcaggcgcag ggagccgatc tcatcattgc
    19261 gatgccccat gcaggctttg aggatattcc cgaaattccc aatatggaaa atgcggtgct
    19321 gcatctgagc agggtggaag ggatcgatgc cattgtgttt ggtcatgccc ataaagtatt
    19381 tcccggccct tcatttatag gtatgacagg tgtggataca gagcagggca ccatccatgg
    19441 cattccagca gtagagccgg gcttctgggg agatcatctg ggtatcattg atctggatct
    19501 ggcccttatt ggagggaagt ggcaagtgac tgcatctgct gccgaggtac gcccggtgta
    19561 tgacccgata cgcaaggaag ccctcgtcca acccgatact gctatccagc aggcggtagc
    19621 agctgaacat gcgggaaccc tagattacat ccgtgcacct gcaggtcaaa cgacagtagc
    19681 agtgaacagc ttttttgccc aggtgatgga tgatgcttcg gttcagctcg tcaatgatgc
    19741 acaaatttgg tatgtgaagc agcagctaca agggagcgag tatgaagggt tgcccgttct
    19801 atcggcagca gctcctttta aaacaggtgg cagatatggt ccggcgtatt ataccgatat
    19861 tcccgcaggg acgctggcga tcaagcatat cgccgacctg tacaattttc cgaatacgct
    19921 gcatgtcgtt cgactgagcg gggcagaaat tcgggaatgg cttgagtggt ctgccggtca
    19981 attcaggcaa attgaccctt tggcaaagga ggagcaagag ctgattaatt ctgattttcc
    20041 aagctttaat ttcgatatca tcgatggcat cacgtatcag attgatgtaa cacagccagc
    20101 cagatatgat actcacgggg aattaaagga cctagaagcg cacagaatcg ttcatatgtc
    20161 ttttgaaggg gaaccaatgg atatgcagcg gagttatctg gttgttacga ataactatcg
    20221 cgcattctcc tctgcgctgg ttaatccggg tggagagcga attatactgg cttccccgga
    20281 tgagaaccga catgtgctga ctgagtatgt gcggcatatg gagacgttga cgccaaaggc
    20341 cgacggtcat tggtccctcg ccccatggtc gggtcgtcca catgtgacct tcctaacctc
    20401 gccgcaagca acgaatgttg cccatgctta ttctgaattg ctctatgaag gactgacggc
    20461 agaaggatac gctaagtttg ctcttgattt tcgtcaattt taaaatattt tgcaagttat
    20521 tgtcctctaa gtccacagca tcaaaataat agaaaaagac tgtctctcag aggacggtct
    20581 tttttcataa aacagattta aaatcgtacg aaactcgtga ttttatatgt cctgagtcgt
    20641 gtttaaagtt attgacctct cgtataatta gacatatact ttgattaaac aaattttggt
    20701 ttaaaaggta atgaaaaagt caccatcatt cgtttgaggg ggtgtccctt tggaaaaaaa
    20761 caccacgatc cgcgcagaga tagaaaagta tattcaaagt gaaggcattt cgatgcaatg
    20821 ttttgtagat gcttctaagg taaatccggg tacacttagc ggtatactta accgaaaccc
    20881 accacggcct atttcagtta atcagcttga tctgattact gaggcgatgg gattggaaga
    20941 aggatctttg ttcgagatgt atgttgatga gtgttttatt cattccttgc cacactggag
    21001 gaggctgcgt ccgtttcttc ttcgttgctc agagttgaac aagctggact gtatacgcag
    21061 tgtgcttggt tatttgatgg acgatttatc gaatgttccg gctatttttg agactgcaga
    21121 agcgatgttt gaggatggtc gacatgaagc ctccatgctt ttgtatgatt gtgtcattga
    21181 gagtgagaag tatacccact ccgaacggtt ggcgattagc tattttcgca tattccagat
    21241 tcagattaag gataaccaac ggaacttgaa ggctgctgta caattccatt tgtaccgtag
    21301 tcgtctaccg gaaatttatg cactggaagg cttacatatg ctatctcaag tgtttgcttt
    21361 aaaaatgcaa tggtccgaga tggaaatgta tgcggacgag ctaagagagt tggcgcaggc
    21421 at
//
