LOCUS       NZ_CP023711            25388 bp    DNA     circular CON 06-APR-2024
DEFINITION  Paenibacillus polymyxa strain C12 chromosome, complete genome.
ACCESSION   NZ_CP023711
VERSION     NZ_CP023711.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5793823)
  AUTHORS   Sun,D., Qiu,J. and Shen,M.
  TITLE     De Novo Assembly of the Paenibacillus polymexa Strain C12 Genome
            Using PacBio Single-Molecule Sequencing
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5793823)
  AUTHORS   Sun,D., Qiu,J. and Shen,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2017) College of Biotechnology and Bioengineering,
            Zhejiang University of Technology, Chaowang Road, Hangzhou 310000,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 105.2x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022649565.1-RS_2024_04_06
            Annotation Date                   :: 04/06/2024 06:53:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,129
            CDSs (total)                      :: 4,973
            Genes (coding)                    :: 4,899
            CDSs (with protein)               :: 4,899
            Genes (RNA)                       :: 156
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 110
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 74
            CDSs (without protein)            :: 74
            Pseudo Genes (ambiguous residues) :: 0 of 74
            Pseudo Genes (frameshifted)       :: 26 of 74
            Pseudo Genes (incomplete)         :: 42 of 74
            Pseudo Genes (internal stop)      :: 21 of 74
            Pseudo Genes (multiple problems)  :: 13 of 74
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:37:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2038622
            Orig. end                         :: 2064010
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023711.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25388
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="10"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..25388
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25388
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15388](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15388)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            936..1976
                     /locus_tag="CPY53_RS08545"
                     /old_locus_tag="CPY53_08560"
     CDS             936..1976
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688423.1"
                     /locus_tag="CPY53_RS08545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08560"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_016818623.1"
                     /transl_table=11
                     /translation="MNIKTIASMAGVSVATVSKIINNYTDISEETRQRVLKIMEETGYR
                     PSSSAKTLATKKSNLVGVIFAGKLNVDFSHPFFVDIINVFKKQIGLLGYDLLFFSNEKF
                     LDNGEDYLARSKYFSVDGCIIIAGDEVEKSVFDLDASPIPCIGVDIELTGASSCYIMSD
                     NQKISMKVVEHFYMNGYREMGFIGIERPSLVIKEREEAFISSLKRFSLDVRPEWIVYGK
                     DYAAEDGYQIAKAWIEQENLPKAIFAATDLLAFGAIRAFKESGLRVPEDIAVVGCDDIE
                     ACRYTDPPLTTVKQDKQKIGRLAAMVLFDLMNKQMDTKCIKVEPELVIRTSCGARQHWN
                     PTRVEG"
     gene            complement(2061..3554)
                     /gene="glpK"
                     /locus_tag="CPY53_RS08550"
                     /old_locus_tag="CPY53_08565"
     CDS             complement(2061..3554)
                     /EC_number="2.7.1.30"
                     /GO_function="GO:0004370 - glycerol kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glpK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1210: glycerol kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818622.1"
                     /locus_tag="CPY53_RS08550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08565"
                     /product="glycerol kinase GlpK"
                     /protein_id="WP_016818622.1"
                     /transl_table=11
                     /translation="MGKYILSLDQGTTSSRAILFNSEGDVVYSAQREFPQYFPHPGWVE
                     QNANEIWSSILGVIASCLSESGVKAKQIAAIGITNQRESVAVWDKNTGLPVYNVLVWQS
                     RQTSDICEELKRQGHEELFHSKTGLLIDPYFSGTKVKWILDHVEGARERAERGDLLFGT
                     IDSWLIWKLSGGKAHVTDYSNAARTLMYNIYELKWDEELLDILGVPKIMLPEVRPSSEV
                     YAHTVDYHFFGQNVPIAGAAGDQQAALFGQACYEKGMIKNTYGTGCFMLMNTGDQPVES
                     KHGLITTIAWGLEEGKVQYALEGSVFVAGSAIQWLRDGLRMFREAKDSEPYAARVSSTE
                     GVYLVPAFVGLGSPYWDSEVRGAMFGLTRGTTKEHFIRATLESLAYQTKDVLTAMEIDS
                     GITVKMLRVDGGAVLNNFLMQFQSDILDATVERPVIHETTALGAACLAGLAIGYWKSTD
                     ELRKRVRVETSFTPTMDEATRDSLYEGWKKAVNATMAYK"
     gene            complement(3586..4410)
                     /locus_tag="CPY53_RS08555"
                     /old_locus_tag="CPY53_08570"
     CDS             complement(3586..4410)
                     /GO_function="GO:0015267 - channel activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688424.1"
                     /locus_tag="CPY53_RS08555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08570"
                     /product="MIP/aquaporin family protein"
                     /protein_id="WP_016818621.1"
                     /transl_table=11
                     /translation="MSPYAAEFIGTMILIALGGGVCAGVSLKKSFAHASGWIVVGLGWG
                     LAVAIGVYAVGPISGAHLNPAVTLALAFQGSFPWQDVPGYIVAQVLGAMAGAGIVILHY
                     WPHWKETEDTAAKLSVFATGPAIDHPFGNVLSEMIGTFIFVLALLSFGANSFTDGLKPL
                     IVGFLVVSIGLSLGGTTGYAINPARDFGPRLMHYLLPIPGKGASNWKYAWVPIVGPLLG
                     GSFAGPFYQAVFKGSMTPAFWILLGVIVVVLLITFRISRIYKNHKMDHKLTA"
     misc_feature    4366..4381
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 23.4"
                     /tool="antismash"
     gene            4729..6210
                     /locus_tag="CPY53_RS08560"
                     /old_locus_tag="CPY53_08575"
     CDS             4729..6210
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1145: Glucose-specific phosphotransferase enzyme IIA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372703.1"
                     /locus_tag="CPY53_RS08560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08575"
                     /product="PTS transporter subunit EIIC"
                     /protein_id="WP_016818620.1"
                     /transl_table=11
                     /translation="MLKFLQKIGKSLMLPVATLPAAGILQGLALINYETDIPLGPGVGG
                     FLNHYVTPFLNEGAGAIFGNLALIFSIGVAIGLAGDAVAALSAVIAYLVLTRILAAVPG
                     IFAYIPDDVKLDMGVLGGIFIGGWSAYLFKKYHNIQLPDWLGFFSGKRFVPMITAFTTM
                     ILAILLGMIWSPIQDGIAAFGNWIVGFGGIGSMVFMIANRLLIPLGLHHVLNSIAWFQI
                     GDYTNAAGEVVHGDLTRFFAGDTSAGMFMSGFFPIMMFALPAAALAFIHTAKSEKRKAI
                     ASIFIGSALASFLTGITEPLEFSFMFIAPLLYGVHALLTGLSGLVVYLLDVKLGFSFSA
                     GLIDYLVNMKLSTHPLRMIPIGLVFALIYYFLFRFIILKFNLKTPGREDDVDDTLLFEA
                     NKSIPVGKASASSGTQSSQAGQVLTYLGGSDNIQSIDACITRLRLVVKDDKAVNDQALK
                     QLGASGIIRLGNGTLQVIFGTRSEALKDEIQRLMS"
     gene            6408..7697
                     /locus_tag="CPY53_RS08565"
                     /old_locus_tag="CPY53_08580"
     CDS             6408..7697
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014277625.1"
                     /locus_tag="CPY53_RS08565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08580"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_026065450.1"
                     /transl_table=11
                     /translation="MKTVQWQWLVLCLAFLTMISGCSGSLSSKGQSSEANLSNSKKITL
                     TLWYWNRSIDDELLVQAEKQFPNIELKTQKIGGDFKAKLKTTLAARSGEPDIVALNDWM
                     VELFPSADRFYDLKELGADRLKDQYLEWKWNQGITPDGKMIAFPMDTGPTALFYRSDLF
                     EQAGLPSDPEQVSASIRTWDDYMAAGEQLRQKFGSHSFLADNIVNVYNQVLAQHTNLYF
                     KPDGSYIGNQSPDIRLGWKTAVDFHRKHLLANADGWTPEWNASVNNGKIASFVGAIWMK
                     QVLTEAAPDTAGKWRVARAPGGDGNLGGSFISILKSSQHPKEAFEVLTWLQSPEHQLEA
                     YHKIGLFPSTPGVYDDPVMETPEPFFGGQATGLIFAASARQVKNSYFGERYPVIHGIVT
                     RRLANVAKQNADPDSLWTETMQRIQRELQR"
     gene            7731..8606
                     /locus_tag="CPY53_RS08570"
                     /old_locus_tag="CPY53_08585"
     CDS             7731..8606
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014277626.1"
                     /locus_tag="CPY53_RS08570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08585"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_016818618.1"
                     /transl_table=11
                     /translation="MLREIWKHRAVYAAISPFYLLFGIFGLFPIGFSLYLAFHKWDGIG
                     DMTYNGWGNFRYLVTDNEFWQAVGNTFVIWVYATIPMLFLALIVAFLLYAPFVKMRTLW
                     RVGFFLPNVTSIVAVAIIFGALFANNFGFLNYLLQLLGLPMIQWLNVPWGIQIAISSMV
                     VWRWMGYNAIIYLAGLQSIPHVLYEAAKIDGATGAQAFFRITIPMLRPVILFTVITSTI
                     GGMQLFTEPQVLVGNDGGAGASGMTIVLYLYRESFINNYFGYGAAVGWGMFLIIALFSI
                     INWKLVQGKK"
     gene            8628..9455
                     /locus_tag="CPY53_RS08575"
                     /old_locus_tag="CPY53_08590"
     CDS             8628..9455
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372706.1"
                     /locus_tag="CPY53_RS08575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08590"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_016818617.1"
                     /transl_table=11
                     /translation="MMQTRAKSIVLYAGLLVGIILSMFPFYWLIVMATRTTSDIYRFPP
                     QLWLGSHFLDNITRVLQQIDFAGAFLNTLFVASSITLLVLFFDSLAGFAFAKFDFPGKK
                     VLFVILLATMMVPSQLSLVPSFVMMASFGWVGTFKALIIPGMVNAFGIFWIRQYAEESI
                     PKELLDAGRMDGCSFFRLYWNVALPILRPAFAFLGAFTFIGAWNDYLWPLIVLTDERKF
                     TLQIALSQLNGIYNTDYAMVIAGTLLAVLPLIILFLFISRQFISDLAAGAIKD"
     gene            complement(10001..11533)
                     /locus_tag="CPY53_RS08580"
                     /old_locus_tag="CPY53_08595"
     CDS             complement(10001..11533)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372709.1"
                     /locus_tag="CPY53_RS08580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08595"
                     /product="radical SAM protein"
                     /protein_id="WP_016818616.1"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     2.3e-07, bitscore: 29.1, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 2e-47, bitscore:
                     160.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 5.5e-11, bitscore: 41.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6e-06, bitscore: 24.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILDSTVMEFFRNIKKQYGNYSRLFKLFQTKNKSYLYDVGTGKVM
                     ECTEIEYVFLNNLQVYGDIEEVIKTTKVNDDTLTILIDLIHVAQEQHLFQAPPLLSFAL
                     SKDEVLENARSHLEQVTLELTEQCNMACHYCIYHSGNIDFREFGRRHMSWQVAELAIDY
                     TLKNSGKKVAVTFYGGEPLIEFKLLKHCVDYTLKNGADKDLTFSMTTNLTLMTAEIAEY
                     LSTVPNFGVVCSIDGPKEIHDCRRVFKNGEGTYDKAINGLKHLINAYGEKSNSLISLSM
                     VTPRPANDVVMKKIQNFFNSLSWVPKDITKNISYVRHSSDIEKTITEKSSMHCYDNPVG
                     NWTIDLMLNNTSISKNTPFTIDFLHKQFSIIHDRILTETPYPDYCLNGCCSPASRRIYV
                     TVNGDFHLCERIGKSPSVGNVYSGIDESVLIDRYIDDYGKESLSQCSKCWAIRLCSVCY
                     VECYDSDKFNIEKKKIACRRSLDMLEHALISYHTILEHKPHLLEELNHITLV"
     aSDomain        complement(11129..11518)
                     /aSDomain="Other_Sactipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a sactipeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CPY53_RS08580_Other_Sactipeptide_rSAM
                     _RRE.1"
                     /evalue="1.30E-09"
                     /identifier="RREFam021.1"
                     /label="CPY53_RS08580"
                     /locus_tag="CPY53_RS08580"
                     /protein_end="135"
                     /protein_start="5"
                     /score="29.1"
                     /tool="antismash"
                     /translation="TVMEFFRNIKKQYGNYSRLFKLFQTKNKSYLYDVGTGKVMECTEI
                     EYVFLNNLQVYGDIEEVIKTTKVNDDTLTILIDLIHVAQEQHLFQAPPLLSFALSKDEV
                     LENARSHLEQVTLELTEQCNMACHYC"
     gene            complement(11499..13172)
                     /locus_tag="CPY53_RS08585"
                     /old_locus_tag="CPY53_08600"
     CDS             complement(11499..13172)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818615.1"
                     /locus_tag="CPY53_RS08585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08600"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_016818615.1"
                     /transl_table=11
                     /translation="MIVLEYLKKYLSKTRKYVFFYIVVTSVLWIIGIIVPYITGIYIDY
                     LVSKSNISIILYFVLLLGIINIVNILIQYLTALFSTKLNNLLLYEICNDIYQKIFKTKL
                     SVFKDKDNAYLVDQINNDSSTVVDFFSNNISNLVLQVITIIISGIIVLKADVLLCVIIF
                     SLIPFYIFTYVVFRKKLYKANLKYKKEANEYYSKKVEQINKLVFIKKNVLFNEMNERLN
                     KAFNSLFRVATSQVKTNYIFSNLNQFILIICYIFVIGIGGHKVVIGQMSIGQFTIINTY
                     LSMIISSTSYLLSLASSYQETKVSIERLNDVMNSENDIYGSTTLEDLEKISIKQLGVKY
                     SEESVFRDFSYDFFKGGIYGICGHNGSGKTTLLNTLIGLYSDLYTGEIAFNNCSIKDID
                     MLDMRRYRISYVEQNPEFLNLPIKEYLKFGITFSKEIASNQDELITAFGLEEIITKANL
                     ENILINENGSNFSGGEKQKLALIRALSKDSFLTILDEPTSALDSKSVSGLIEILTKQKS
                     RRITIVVSHDQRLLAACDHILNIETQEERDDIGFHSYGVL"
     gene            complement(13419..14066)
                     /locus_tag="CPY53_RS08590"
                     /old_locus_tag="CPY53_08605"
     CDS             complement(13419..14066)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818614.1"
                     /locus_tag="CPY53_RS08590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08605"
                     /product="hypothetical protein"
                     /protein_id="WP_016818614.1"
                     /transl_table=11
                     /translation="MLMLKKMCIVLCGFLLMGMPLGASSNAASNDVKNINLTAINCNVT
                     VTKTSASDFSYEYNKSLYTVTSTLSGSTIYITVKGKGSANGISDRVNILIPDKSYEKIT
                     VESTKAGVSLPELNTNLDITGVDGSSMSVRVPVGYSKAISYDNTKGSGSLTFSKGASDY
                     TVTVKTTASALSVPAGWPLFRPNLTYNYINGAGKAKINITLENSAFSIAAQK"
     gene            complement(14060..15388)
                     /locus_tag="CPY53_RS08595"
                     /old_locus_tag="CPY53_08610"
     CDS             complement(14060..15388)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372712.1"
                     /locus_tag="CPY53_RS08595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08610"
                     /product="radical SAM protein"
                     /protein_id="WP_016818613.1"
                     /sec_met_domain="PTHR43273 (E-value: 3.3e-39, bitscore:
                     133.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.3e-14, bitscore: 52.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.7e-10, bitscore: 39.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.4e-16, bitscore:
                     57.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKASQYNFIFNDIIENTDKTVLYNSRTGALAVLEPEYYKQFCELT
                     NNGLAINNDTYLKNLIECGYIVEDNMNEKAYVKVNLLKNRFESSNLMLTIAPTMACNFR
                     CVYCFEKDQYHNKTMSEETTQSIVNFVKTNASKLDTLNVTWYGGEPLIAMKQIVRISED
                     FLEICKENNIQYTASVITNGYLLNKEKVQTLISCGVNDIQVTVDGPKEVHDLRRPLVSG
                     RGTFDVIMNNLKQIKGMIKIFMRINTDQDNWLNLHEIVGFLKENSLLENVIPYLGLVTP
                     TNGKYEGTKCLTDEMYSKFNLKFMSENDIPISYIYPAPKGNYCSADKYNSFVIDPLGHL
                     YKCWSDIGIIEQCVGNINEDTSVKWNTELLGCYLLYDPTEDEKCSDCKYLPVCLGGCPH
                     NRMADFNICEQYRYNLQEYITECTKVLLAGQLTENKKEVSESC"
     misc_feature    complement(15443..15458)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     misc_feature    complement(15883..15898)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.64"
                     /tool="antismash"
     gene            15955..16710
                     /locus_tag="CPY53_RS08600"
                     /old_locus_tag="CPY53_08615"
     CDS             15955..16710
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818612.1"
                     /locus_tag="CPY53_RS08600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08615"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_228552499.1"
                     /transl_table=11
                     /translation="MVYLFQVAVCDDDPAMHKILQHFFMCMSVSESLDFNLQFFLSGED
                     LIKSYSSQERYPFHIILLDIEMRELSGIETAKLIRLFPDREVQIIFLTNYPEYMLESFE
                     VQAFQYLLKPLTYKLFVEKINKLCHYMRSSVSHFLSVKNKTEHLVLRHSEIIAISKGEN
                     NYIHNELCIATDSHNYFISGTLKAVYEQLKYPFVFIHRSIIVNLVHIRKFSATSVIMSN
                     EQEFPVGRSHAKSLREAYARFIISRFQEG"
     gene            17109..17729
                     /locus_tag="CPY53_RS08605"
     CDS             17109..17729
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372715.1"
                     /locus_tag="CPY53_RS08605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_230877304.1"
                     /transl_table=11
                     /translation="MQEKRYKETTRSLSDIKRSIHDFKKQLIFVRACLQEQRTEEGVNH
                     INQTLKNIDSPKLHITTGHLVIDALVNHTFSIANKSGIAFFHQIHINPANISIGSHDLC
                     IVLGNVFDNAIEAVMQLPRKKEHSIHLEIFTDNFALWIYVRNSKSNYLNTAFSTKTYNS
                     PSKKHGYGLLNIQQVIKKYGGYLNTTITDSHFQITIMLPCNNS"
     gene            complement(17856..19274)
                     /locus_tag="CPY53_RS08610"
                     /old_locus_tag="CPY53_08625"
     CDS             complement(17856..19274)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005283 - amino acid:sodium symporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1153: Amino acid carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016324662.1"
                     /locus_tag="CPY53_RS08610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08625"
                     /product="sodium:alanine symporter family protein"
                     /protein_id="WP_038978208.1"
                     /transl_table=11
                     /translation="MNLVHVLETIDSWMWGAPLLILVMGTGLWLTIRLKMLQIIRLPLA
                     LKLIGKAPDEGSGDVSSFGALSTALAATVGTGSIVGVATAIKLGGPGSLFWMLVAAFFG
                     MATKYAEGLLSVKYRVKDRNGQFSGGPMYYIENGLGRRFKPLAMLFAFSGILVALFGIG
                     TFPQVKAIVSSTESSFGVPTVVTAIIISVLTAVVTIGGLKSIAKVSTKIVPFMSGLYIV
                     VCLIVLIKFAGELPHAIALVLQGAFSTTSATGGFAGATIMLAMRSGVARGIFANEAGLG
                     SAPIAAAAAKTKWPAEQGLISMTGVFIDTMIICNLTGFTLLVTGIWSGNDDGGLMTQHA
                     FSSAFPAGAELVTISLILFAFTTILGWNYYGERCVEYLLGVKWIKPYRYLFIVLVAGGA
                     FIKLDAIWLLADIFNAMMAFPNLIALLGLSGIVVAETRTYMNSLYPNKNKGILAGANVG
                     AAIQVEEKGQTVNS"
     regulatory      complement(19433..19527)
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    19636..19654
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.42"
                     /tool="antismash"
     misc_feature    complement(19677..19692)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 25.74"
                     /tool="antismash"
     gene            complement(19792..21249)
                     /locus_tag="CPY53_RS08615"
                     /old_locus_tag="CPY53_08630"
     CDS             complement(19792..21249)
                     /EC_number="3.2.1.-"
                     /GO_function="GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010348049.1"
                     /locus_tag="CPY53_RS08615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08630"
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="WP_016818609.1"
                     /transl_table=11
                     /translation="MTKTLKGFPKNFLWGGATAANQLEGAFDVDGKGLSSADMIAYVPK
                     SERKNDHAIEISSERLEDILAGKVNARFPKREGVDFYHHYKEDIALFAEMGFKVFRMSI
                     HWSRIFPNGYDAEPNEAGLQFYDNVFDELRKYGIEPLVTLSHYETPLGLTQKYNGWLGR
                     EVVDHYVKYAETVFTRYKDKVKYWLTFNEINVMTMSPFTGGGVVIDRVENKQQAIYQAL
                     HHQFVASALATKRGHEIIPGAQIGCMLARIESYPHTCNPEDILKAQHENQMNLFFTDVH
                     ARGEYPNYMNRYFEENNIVIQTEPGDAEILKNNTVDFISFSYYMTLTVSAGPEGEKAAG
                     NLIGGVKNPYLQSSDWGWQIDPIGLRVTLNTFYDRYQKPLFIVENGLGAYDKVEEDGSV
                     HDTYRIDYLRQHIAQMKEAIADGVDLIGYTSWGPIDLVSMSTSEMSKRYGFIYVDLDDD
                     GNGTLQRSKKDSFNWYKNVIATNGEEL"
     gene            21461..22432
                     /locus_tag="CPY53_RS08620"
                     /old_locus_tag="CPY53_08635"
     CDS             21461..22432
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007431750.1"
                     /locus_tag="CPY53_RS08620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08635"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_016818608.1"
                     /transl_table=11
                     /translation="MSNLDQIAKLAGFSKATVSRVLNQSPHVSHETRAKILKIMQELDY
                     VPNRNAISLSKGQTLQIGIITSTINEIVLAFLDSFVEIAGQYEFQTIIYTSGEDKKKEL
                     QAFEDLKRKRVDALVIISCVNDTDFLSTYCKYGPIVAWQRMEHTDIRSVAMDQYEGYML
                     ALKHLIQKGYTRIANAFGRPSSINTHSRQRAYEQIMSEHNLPVLPHWNYSSIYNIRDGE
                     QVVRNLLQHREEFPEAILCANDYVAVGILCEARRQLLRVPEDLAIVGFDNTELAHTMGI
                     TTVQNPIMAQAQNAFFMLSPQLIGRQMELHSLEYSLIERTTT"
     gene            22666..23514
                     /locus_tag="CPY53_RS08625"
                     /old_locus_tag="CPY53_08640"
     CDS             22666..23514
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818607.1"
                     /locus_tag="CPY53_RS08625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CPY53_08640"
                     /product="PRD domain-containing protein"
                     /protein_id="WP_016818607.1"
                     /transl_table=11
                     /translation="MIIEKVLNNNVLLTKNDKGKEVIVMGRGISFKKVAGDQVDDHKID
                     KIFMLNENEFTARLTELLNDIPVSHLEVVNEIVTHAAEVLDTELSDNIYLTLTDHIHFA
                     IQREEKGLALKNAMLYEIKRFYKKEFAVGLDALQKIENTLGVKLGEDEAGFIALHMVNA
                     RIDGNEMKATLKMTEIVQHILNIITYHYGIVLDESSFSYSRFLTHLQYFAMRVIRKEVI
                     HSGEEFLYNQVKQTYTEAFACAQKINEYLEKTYDQYLSKDEYVYLTIHIHRVTERNNIS
                     G"
     misc_feature    complement(23552..23570)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.98"
                     /tool="antismash"
     misc_feature    complement(23641..23656)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 24.77"
                     /tool="antismash"
ORIGIN
        1 ataggccata catctttacc gccgaaacca atcggttcta cgccgttatc tttgagcacc
       61 ttcataacat tcaccagttc gtcccatgtc gtgggcacag caagattata tttttcaaaa
      121 atctctttgt tataaaacag tcctgtcagg gccaccttcc ccatgttcac accatatacc
      181 ttgtcgttat aggtcatggc atttttgaca tctgtaggat tatagttttt gataaaagct
      241 tgatctgaca gatctgcaat gagtcctccc tcgatccact gcttccacat cggatcagca
      301 gctcccttag accattcctg cggtgcgcct acgaagctga atttcagagg aataatatct
      361 gcatcaccgg ttgaacccgc attcatacgc gtttgcatca gttgatcata agtggaatca
      421 gcaggaaccg tcgtatactc cacctgaaca tcaggatact tctcttcaaa ctttttatta
      481 aattccttta tatagttatt aatattctcc tgctgccaat gaataatttt taacgtgacc
      541 tttttattcc cgttctgccc agcttcgtta cctttaccgc aagcggctaa taccacgatt
      601 aaagcggtta caacaagtaa agaaaaacac tttttcagca ttgcaaaatt ccccctgtaa
      661 tcttagaata aatgcactca ctcttacgaa agcggtttag ttaattacag ctactattat
      721 gtatcgaata gcctgtattt gtaaatagca atttgtaaat tatcaaaaaa tcattaacta
      781 tcgttaaatc gaacttcatt atccataata tattaggatt tatcctataa tagcacggtt
      841 gactctcttc tatgaggtag catagaatac gagtaatcat taattttaga atgcaaggtc
      901 aaatgaacta aatcagttta gttacggagg attccatgaa tataaaaaca atagctagca
      961 tggcaggcgt ttcagtagca acggtttcga agatcataaa caattacaca gatatcagtg
     1021 aggaaacccg gcagcgagta ctcaaaatta tggaggaaac aggctataga ccttcctcct
     1081 cggctaaaac gcttgctacc aaaaaatcta atctggtagg cgttatattc gctggcaagc
     1141 tgaatgtcga ttttagccat cctttttttg tagacatcat taatgttttc aaaaagcaga
     1201 ttggcttgct cggttacgac ctgctgtttt tttcgaatga gaaatttctg gataatggag
     1261 aggactattt ggctcgctca aaatatttct cagtggacgg gtgcattatt attgccggag
     1321 acgaagtgga gaagagtgtt tttgatctcg atgccagccc tatcccctgc atcggtgtcg
     1381 atatcgaact aaccggagcc agttcctgct acatcatgtc cgacaatcaa aagatttcaa
     1441 tgaaggttgt tgagcacttt tacatgaatg gataccgcga aatgggtttt ataggcatag
     1501 aacgcccctc cttggttatt aaagagagag aagaagcttt tatctcatca ctaaagcggt
     1561 ttagccttga tgtcagaccg gaatggatcg tgtatggcaa ggactatgca gcagaggatg
     1621 gataccagat cgcaaaggcg tggatagagc aagaaaattt accaaaagct atttttgcgg
     1681 ctaccgacct gcttgccttt ggtgccatcc gtgctttcaa ggagagcggc ttgagggtac
     1741 ccgaggatat tgccgtagta ggatgtgatg atattgaagc ctgtcgttat accgatcctc
     1801 cactgacgac tgtaaaacaa gacaagcaaa aaataggtcg tctggccgct atggtgctgt
     1861 ttgacctgat gaataaacaa atggatacga aatgtattaa agtggagccc gaactcgtca
     1921 ttcgcacctc ctgcggagcc cggcaacatt ggaaccctac aagggttgag ggatagcaca
     1981 tacctaaaaa aggtgactcc tgtcgaatac agaagtcacc tttttgcagt tatataacaa
     2041 gagccctttc gtttaagcca ttatttgtag gccatcgtcg cattcacagc ctttttccag
     2101 ccttcataca ggctgtcacg tgttgcttca tccatcgtag gggtaaaaga agtttccact
     2161 ctcactcgct tacgaagttc gtctgtactc ttccagtatc ctatcgccaa ccctgccaga
     2221 cacgcggcac ccagcgccgt tgtctcatgg ataactggcc gttccaccgt cgcatccaga
     2281 atatcgctct ggaattgcat caggaaattg ttcaacacgg ctcctccatc cactcgcaac
     2341 atcttcaccg taatacctga atcaatctcc atggctgtga gcacatcctt ggtctgataa
     2401 gcgagcgact ccagggtggc acggataaaa tgctccttcg tggtcccacg tgtcagacca
     2461 aacatcgctc cacgcacctc gctatcccag taggggctgc ccagcccgac aaaagcgggt
     2521 acaagatata ctccttctgt ggaggaaaca cgggccgcat aaggctcact gtccttcgct
     2581 tcacggaaca tgcgcagccc atctcgcagc cactggatcg cagagcccgc aacaaacaca
     2641 ctcccttcaa gtgcgtattg cactttgcct tcctccagcc cccaagcgat ggtcgtgatc
     2701 agaccgtgct tggattcaac cggctgatct cccgtattca tcaacatgaa gcaacctgta
     2761 ccgtaagtgt ttttgatcat tcctttttcg taacaagcct gaccgaacaa ggctgcctgc
     2821 tggtcacccg ctgcaccggc gatcggtaca ttctgaccaa aaaaatgata atccacggtg
     2881 tgcgcatata cctcggaaga aggccttacc tcaggcaaca tgattttcgg aactcccaga
     2941 atatccagta gctcttcatc ccactttagc tcataaatat tgtacatcag cgttctggcc
     3001 gcattggagt agtctgttac atgggccttt ccgccggata gtttccagat tagccacgag
     3061 tcaatcgtac caaataataa gtcacctcgt tccgctcttt cccgcgctcc ttctacatgg
     3121 tccagtatcc actttacttt agtgcctgaa aaatacggat cgatcaatag ccctgttttg
     3181 ctgtgaaaca actcctcatg cccttgccgc ttcagttctt cgcaaatatc cgaggtttgg
     3241 cgtgattgcc atacgagtac gttatacacg ggtaatccgg tatttttgtc ccacacggcc
     3301 accgattctc gctgattggt aatgccgatg gcagcaattt gttttgcttt tacaccggat
     3361 tcggaaagac aggaggcaat aacgcccaga atagaactcc agatttcatt cgcattctgc
     3421 tctacccagc cggggtgagg aaaatattgc ggaaattccc gctgggccga gtacaccaca
     3481 tctccttcgc tattgaacaa aatcgctctt gaacttgtcg ttccctggtc tagtgacaaa
     3541 atatattttc ccatgttcat ctctccccgt gtaaatccat cgtttttacg ctgtaagctt
     3601 gtgatccatt ttatgatttt tataaatacg actaatacgg aaggtaatca agagtacaac
     3661 cacgataact cctaataaaa tccagaacgc cggagtcata ctccccttaa aaacggcctg
     3721 ataaaatgga cctgcgaaag atccccccaa tagcggtcct acaatgggca cccatgcata
     3781 tttccagttg gatgctccct taccgggtat cggtagtaaa taatgcatca gacgcggccc
     3841 aaaatccctc gctggattga tggcatagcc cgttgtgcct ccaagggata aaccgatact
     3901 gacaaccaaa aaaccaacaa ttagcggttt aaggccgtct gtaaacgaat tggcaccaaa
     3961 cgacagtaaa gcaagaacaa agataaaagt acctatcatt tcactaagca cgttaccaaa
     4021 cggatgatca atagctggtc ctgtcgcaaa tacactgagt ttggctgctg tgtcctccgt
     4081 ctctttccag tggggccaat aatgcaaaat gacgatccct gcacccgcca tggctccaag
     4141 aacctgagcc acaatataac cgggaacatc ctgccatgga aaactaccct gaaatgccaa
     4201 cgcgagtgta actgccggat tcaaatgcgc tccgctgatt ggacccaccg catacacccc
     4261 aatagctacc gcgagccccc accccaatcc gaccacaatc cagccggaag cgtgggcaaa
     4321 agactttttc agggacaccc ctgcgcacac tccgccacct agggcaataa gaatcattgt
     4381 ccctatgaat tcggctgcgt atggcgacat acaaccaacc tcctcaatag atcatccgat
     4441 tttgatcgtt gtcatcgcgc aaaaaaaaga aaagccatca caaaccaacc ctgtgctgta
     4501 acatgggatg tctgcgtggc tctcttgtct ccgtcacgat tattaactta aatttgatat
     4561 tatataagca tgtaagcgat gtcaactgcg gatttacgtc ttctgatatc ctaaaataat
     4621 cgttgaccat gttagattgc ccgatttatg atgtaaaaaa atggctgaat gtaaggattt
     4681 caggatgaat acgacactcc caaacttgat gatgaaggga agaatgttat gctgaaattt
     4741 ctgcaaaaaa tcggcaagtc attaatgctt ccagtagcta cattacccgc cgcagggatt
     4801 ttgcaagggc tggctctcat taattatgaa acggatattc cgcttggccc tggagttggt
     4861 ggatttctga atcattatgt cactcctttt ctgaatgaag gggcgggtgc catcttcggc
     4921 aacctggcgc ttattttctc catcggtgtt gctattggtc tggcaggcga cgcggtagcc
     4981 gcactttcgg cagtcattgc ctatttggtg ctgacccgta ttttggcggc cgtaccgggt
     5041 atatttgcgt atattccaga cgacgtcaag ctggacatgg gcgtattggg cggtattttt
     5101 atcggcggat ggtctgctta tctgttcaaa aaatatcata atattcaact tccagattgg
     5161 cttggctttt tttcgggcaa acgttttgtc cccatgatta ccgccttcac gaccatgatt
     5221 ttagccattc tgctcggcat gatctggagt ccgatacaag atggcattgc agccttcggc
     5281 aactggattg ttggctttgg tggaatcggg tcaatggtgt tcatgattgc caatcgactg
     5341 ctgatcccgc tcggtctgca tcatgtgctg aactcgatcg catggtttca aattggggac
     5401 tataccaatg ctgcaggtga agttgttcat ggtgacctga cacgtttttt cgcaggcgat
     5461 acatcggcgg gtatgttcat gtccggcttc ttccccatta tgatgttcgc tctgccagcg
     5521 gcggctctcg cattcatcca tacggccaag tcggaaaaac gtaaagctat cgcttccatc
     5581 tttatcggtt ctgcgctggc gtcgttcctg accggtatta ctgagcccct cgaattttct
     5641 tttatgttca ttgcacctct gctttacggc gttcatgctc tgctaacagg tctgagcggc
     5701 ctagtcgtat acctactgga tgtcaaactc ggcttttcct tttcagcagg actcattgac
     5761 tatctggtca atatgaagct ctccacccat ccattgcgaa tgatcccgat tgggcttgtc
     5821 ttcgccctca tctattattt tctgttccgc ttcatcatcc tcaaattcaa cctaaagact
     5881 cccgggcgcg aagacgatgt agatgacacc cttctatttg aggctaacaa atccataccc
     5941 gttggaaaag caagcgcctc atccggcacc cagtccagtc aggcaggcca ggtcctaacc
     6001 tatctcggcg gttcagacaa tatccaaagc attgatgcct gcatcacgcg gttgcgtctt
     6061 gtcgtcaagg acgacaaagc ggttaacgat caagctctta agcagctcgg agcgtcagga
     6121 attatcaggc ttgggaacgg taccctacag gttattttcg gtactcgatc cgaagctctg
     6181 aaagatgaga tacaacgatt gatgtcatga agctaatccc ctgccttaag cacgtgcgat
     6241 cttcctataa cagacgcacg tgcttttttt tatggataaa cgtttcgaat tttttgtttt
     6301 tggttaaggc aatgcacata aatgggtaac agcttcatat gatggagcta aaccatttac
     6361 aacttgttca gcaggcagat tattcagaca gcaaggaggg aaatgatgtg aagacagtac
     6421 aatggcaatg gctggtatta tgtcttgctt ttctcactat gattagtggt tgtagtgggt
     6481 ccctatcctc taaaggtcaa tcatctgaag ctaatttgtc aaacagcaaa aagataacgc
     6541 ttacattgtg gtactggaac cgttctattg acgatgaatt gctcgtccag gcagaaaaac
     6601 agtttcccaa cattgaatta aaaactcaaa aaataggcgg tgactttaaa gccaagctga
     6661 agacaacgct cgcagctcgt tccggtgaac cggacatcgt agctctgaac gactggatgg
     6721 tggagctatt cccgagtgcg gatcgttttt atgatctaaa ggaactcgga gcagaccgac
     6781 tgaaggatca atatttggaa tggaaatgga atcagggcat cactcctgat ggtaaaatga
     6841 ttgcatttcc catggatact gggcctaccg ccctcttcta tcgaagcgac ctgtttgaac
     6901 aggcaggctt gccaagtgat cctgaacagg tcagtgcctc gatccgcaca tgggatgatt
     6961 atatggcagc cggagaacaa cttcggcaga aattcggaag ccattcattt ttggccgata
     7021 atattgtaaa cgtttacaat caggtactcg ctcaacatac gaacctgtac ttcaagccgg
     7081 acggaagtta tatcggcaat caatctcctg acatccgcct gggctggaaa accgctgtgg
     7141 atttccacag gaagcatctg ctcgccaatg cagatggctg gactcctgaa tggaatgctt
     7201 cggtcaataa cggcaaaatc gcctcgttcg taggggcaat ctggatgaag caagttctca
     7261 cagaagccgc accggataca gcgggcaaat ggagagtcgc ccgtgctcct ggaggagacg
     7321 gcaatctggg agggtctttc atctctatcc tcaaatctag ccaacacccc aaagaagcct
     7381 ttgaagttct gacctggctg caaagcccgg aacaccaatt ggaagcctac cataaaatcg
     7441 gcctgttccc atccactccc ggcgtctatg acgatccagt catggagaca cccgagcctt
     7501 tctttggtgg tcaggccact ggcctcattt ttgccgcctc cgcacgtcag gtaaaaaata
     7561 gctatttcgg cgagcgctat cctgtcatcc acggcattgt gacccgtcgt cttgccaatg
     7621 tggccaaaca aaatgccgat cccgactcat tatggacgga aacaatgcaa cgaattcaac
     7681 gggaattaca gcgttaaaaa acaaaacttc aaaaaaggcg tgtggacaat atgctgagag
     7741 aaatctggaa gcaccgggcc gtttatgctg cgatctcgcc attttatttg ctgtttggca
     7801 tctttggctt gtttccgatt ggcttttcat tgtacctggc gtttcacaaa tgggacggga
     7861 tcggagacat gacctacaac ggctggggca actttcgtta ccttgtgaca gacaacgaat
     7921 tttggcaggc tgtaggtaat acgtttgtga tctgggtgta cgccacgatt ccaatgctat
     7981 ttctagcact cattgttgcc tttctgcttt atgccccttt tgtgaaaatg cgcaccttat
     8041 ggcgagttgg attcttcctg cccaatgtga catctattgt tgctgttgcc atcatctttg
     8101 gcgccttatt tgccaacaat tttggatttc tcaactacct tttgcagctc ttggggctac
     8161 ctatgatcca atggctgaat gtgccatggg gtatccaaat cgccatttct tccatggtcg
     8221 tctggagatg gatgggttac aacgccatta tctatctggc tgggctccag agtatcccac
     8281 atgtgctgta tgaggccgcc aaaatagacg gggcaaccgg agcgcaagct tttttccgca
     8341 tcaccattcc gatgctgcgc ccagtcattt tgtttacggt cattacgtcc accatcggtg
     8401 ggatgcagct gttcaccgag ccacaggtcc tggtcggtaa tgacggcggt gccggggcaa
     8461 gtggcatgac catcgtttta tacctgtacc gcgagtcgtt cattaacaac tattttggat
     8521 atggcgctgc tgtcggatgg ggcatgtttc tcatcattgc tctattctcc atcatcaatt
     8581 ggaaactcgt tcaaggtaaa aaataacgat ggaaggagct ttaccacatg atgcagacac
     8641 gtgcaaaatc cattgtttta tatgctgggc tgttggtagg tatcatcctg tcgatgtttc
     8701 cattttactg gctaatcgtc atggcaaccc gtacaacctc agacatctat cgttttccgc
     8761 cacaattgtg gttgggcagc cacttcctgg ataacatcac gagagtattg cagcagattg
     8821 attttgccgg cgcctttttg aatacccttt ttgtagccag ttcgattacc ctattggtgc
     8881 tgttttttga ttcactggcc ggttttgcat tcgcaaagtt tgattttccg ggcaaaaagg
     8941 tgctattcgt cattctgcta gctacaatga tggtcccttc acaactttcg ctcgtcccct
     9001 cctttgtcat gatggcttcc tttggatggg taggtacgtt caaagcgctc atcatcccgg
     9061 gtatggtaaa tgccttcggg attttctgga ttcgtcagta tgcagaagaa tctattccca
     9121 aggagctcct ggatgcgggg cgtatggacg ggtgcagctt ttttcggctg tactggaatg
     9181 tagcactgcc gattttacgc cctgcgttcg cttttctcgg cgcatttacc tttataggag
     9241 cttggaatga ttacttatgg ccattaatcg ttttaacgga tgagcgcaaa ttcaccctcc
     9301 agattgcatt gtcgcagttg aacgggattt acaatacgga ttatgcgatg gtcattgctg
     9361 gcaccctgct ggctgtactt cctcttatta ttttgtttct tttcatcagc cgccaattta
     9421 tttccgatct tgccgctgga gcgatcaaag attagcttcg cttgattccc cttttacttg
     9481 ctctaaagcg tcttcgaaac tggacttaag ctctggagag gaattgcaca actatgagct
     9541 ccgtgcgatt ttattaattg gaacgactgc tctaaacgga acactcaaat agactacttc
     9601 gaggctgagt ttacacacga ttgaacatgt actgtctacc tgttatccat atttccttgt
     9661 aaattagcct ccatagttat ctaacgatta ataaaaatcg cttccactca tttaacagag
     9721 tagaagcgat ttttcaaaaa ttaaataaac gtttctctaa taggtcaact taaagccata
     9781 tcatagtttg cactactatt catttgccta tcagagcgac atttacatgc acaattcgag
     9841 ccatgtccga agtcatgaag tatattatta gcaccggaag aacaaataca agataaagga
     9901 acaattccaa gggtatttgc cattaaaggc ttccttccaa atggatttac aattctcaat
     9961 ttataatcct ccttcgactc gttttgataa tagattggaa ttacaccaat gtaatatggt
    10021 ttaattcctc taataaatgt ggtttgtgtt ccaagatagt atgatagctt attaatgcat
    10081 gttccagcat atctaaagaa cgcctacaag ctattttctt tttttcgata ttaaacttat
    10141 cactatcgta acattcgacg taacaaaccg aacaaaggcg tatagcccaa catttggagc
    10201 actgggacaa actctcctta ccatagtcgt ctatataacg atcgattaat acagattcgt
    10261 ctataccact ataaacgttt ccaactgaag gtgattttcc aatgcgctcg cataaatgaa
    10321 agtctccatt taccgttaca taaattcttc ttgaggcagg tgaacagcag ccgtttaagc
    10381 aatagtccgg gtaaggagtt tcagttaaaa tcctatcatg tattattgag aattgtttgt
    10441 gtaaaaaatc gattgtaaag ggagtatttt ttgatataga agtattattt aacattagat
    10501 caattgtcca gttccctaca gggttatcat aacaatgcat agagcttttt tcagtaatcg
    10561 ttttttctat gtcagacgag tgtctcacat aagaaatatt tttagtaata tccttaggta
    10621 cccacgaaag agaattgaag aaattttgaa tttttttcat aactacatca ttagctggtc
    10681 taggtgttac catgcttagc gatataagag aattactctt ttctccataa gcattaatta
    10741 gatgtttaag accattaatt gccttgtcat acgtgccctc accattttta aataccctcc
    10801 tacaatcatg tatttccttt ggaccgtcaa tactacaaac tactccaaag ttaggaactg
    10861 tagatagata ttctgcgatt tcagcagtca ttaaggttaa gtttgttgtc attgaaaatg
    10921 ttaaatcttt atcagcacca ttttttaaag tatagtctac acaatgcttt aataatttaa
    10981 attctattaa tggctccccg ccataaaaag ttaccgccac ttttttacct gagtttttca
    11041 gagtataatc gattgctaac tctgctactt gccaggacat gtgcctgcgt ccaaattccc
    11101 tgaagtctat gttccctgaa tgatatatac aatagtggca tgccatatta cattgttcgg
    11161 tcaactccag agtaacctgt tctagatgac ttcttgcatt ttctaaaacc tcatcttttg
    11221 atagtgcaaa ggataaaaga ggaggtgctt ggaataaatg ctgttcctgc gcaacatgta
    11281 ttaagtcaat tagaatagtc aatgtatcat cattaacttt ggtagttttt attacctctt
    11341 cgatatctcc gtacacttgt aagttattta gaaatacata ctctatttca gtgcattcca
    11401 taactttgcc tgtgcccaca tcatacaaat aggatttatt ctttgtctga aacaacttaa
    11461 acaatcgtga gtaattccca tactgttttt tgatgtttct aaagaactcc ataactgtgg
    11521 aatccaatat catcacgttc ctcttgggtt tcaatattca aaatatggtc acatgctgct
    11581 aatagtctct ggtcatgtga tactacaatt gttatccttc ttgacttttg cttggtcaat
    11641 atttctataa gtccacttac actctttgaa tctaaggctg atgtgggctc atcaagaatc
    11701 gttaagaaag aatctttact taatgcacga atcaaagcta atttttgctt ttcaccacca
    11761 gaaaagttgc ttccattttc atttattagt atattttcaa ggttagcttt tgttattatc
    11821 tcttcaagcc caaaagctgt tataagctca tcttgattac tggcaatctc ttttgaaaaa
    11881 gtaattccaa atttcaaata ttcctttatt ggtagattta aaaactccgg attctgttct
    11941 acataagaaa ttctataacg cctcatatca agcatatcta tatctttgat ggagcaatta
    12001 ttaaaagcta tttctcctgt gtaaagatca ctataaagac ctatcagagt attaagtaat
    12061 gttgttttgc ctgaaccatt gtgaccacaa atcccgtaaa ttcccccctt aaaaaaatca
    12121 taagaaaagt ctctaaatac gctttcctcg gaatatttaa cacctaattg tttaatactt
    12181 attttctcta aatcttcaag tgttgtacta ccataaatat cattttcaga gttcataacg
    12241 tcatttagcc gttctatcga tactttcgtc tcttggtatg aacttgctaa gcttaataaa
    12301 tatgaagttg acgagatgat cattgaaagg tacgtgttaa ttatggtgaa ctgccctata
    12361 ctcatttggc caattacaac tttatgacct ccaattccga ttacaaatat atagcagatg
    12421 atcaatataa attgatttag attggagaaa atataattag tttttacttg tgaagtcgca
    12481 actctaaata atgaattaaa tgctttattt agccgctcat tcatttcatt aaagagtaca
    12541 ttcttcttta taaaaaccaa tttgttaatt tgttcgactt ttttagagta gtattcattt
    12601 gcttcttttt tgtatttcag atttgcttta tacaattttt ttctaaaaac cacatatgta
    12661 aatatataaa aaggaataag cgagaaaatt ataacgcata gtagtacatc agcttttaaa
    12721 acaataatac cactgataat tattgtgatt acttgcaata ctaagttgga aatattattt
    12781 gaaaaaaagt caactactgt ggatgaatca ttattaattt ggtcaactaa gtatgcatta
    12841 tccttatctt tgaagaccga cagtttagtt ttgaatattt tttgatagat atcattgcag
    12901 atttcgtata ataataaatt attcaatttc gtagagaaaa gggcagttaa atattgtatg
    12961 agaatgttta ctatatttat aatccccagt aacagtacaa aatataaaat gatacttata
    13021 ttactttttg atactaaata atcaatatat atgcctgtga tgtaaggaac aataattcct
    13081 ataatccaca atactgaagt aacaacaatg taaaaaaata catacttgcg cgtttttgaa
    13141 aggtattttt tcaagtattc taggactatc atattcatca cctatgtttc atattaggta
    13201 aatcttagcg agatgctaaa aacagcatct cgctaagtaa tgttacttct cttatgctac
    13261 atcttgtagg aacaagaaag agtacagcca cttgaaccgt ggaaaggaca atgtgcactt
    13321 acttgtacag cactttttac caatacgtcc atggtttttc cctccttaaa atttaattta
    13381 tataaataac atacagttta aaaactatat gctacttatc acttttgagc tgcaatagaa
    13441 aatgcactgt tttcaagcgt gatatttatc tttgctttac ctgcaccatt tatatagtta
    13501 tatgttaagt ttggtctaaa caatggccat cccgcaggaa cacttaatgc acttgcagtc
    13561 gtcttaactg taactgtgta atccgaagct cctttactaa aagttaagga acctgaacct
    13621 tttgtattgt cataactaat ggcttttgag tatcctacag gcacccgaac tgacattgag
    13681 gaaccatcta cacctgtgat atcaagatta gtatttagct ctggaagtga aactccagcc
    13741 tttgtacttt ctaccgttat tttttcataa cttttatcag gaattaaaat attaactctg
    13801 tcggaaatgc cgttagctga gcctttcccc tttactgtga tgtaaattgt agatccactt
    13861 aatgtagaag tgacagtata caaggatttg ttatactcat aactaaaatc acttgctgaa
    13921 gtttttgtaa cggtgacatt acaatttata gccgttagat tgatattctt aacatcattt
    13981 gaagctgcat tacttgaagc acctaatggc atccccataa gtaagaaacc acataaaaca
    14041 atacacattt tttttagcat taacatgatt cagaaacctc cttcttattt tccgttaatt
    14101 gtccagccag taatactttc gtgcactcgg taatatactc ctgcaaatta taacgatatt
    14161 gctcacatat gttaaagtct gccattctat tgtgaggaca tcctcctaaa cacacaggta
    14221 agtacttaca gtctgaacat ttttcatctt cagtaggatc atataataaa taacaaccaa
    14281 gaagctcagt attccatttc actgatgtat cttcatttat atttccaaca cactgctcaa
    14341 taattccaat atcgctccaa catttatata aatgaccaag aggatcaata acgaaactat
    14401 tatatttgtc cgcagaacaa taattacctt taggtgcagg ataaatataa ctaattggga
    14461 tatcattttc cgacataaat tttaaattaa attttgaata catctcgtct gtcaagcact
    14521 tagttccctc atactttcca ttcgtcggcg taactaatcc tagataaggt attacatttt
    14581 ccaataaaga attttccttt aagaatccta cgatttcatg taaattcaac cagttgtctt
    14641 ggtcagtatt tattctcata aatatcttaa tcatcccttt aatttgcttg aggttattca
    14701 ttatgacatc aaatgtccct cttccactta ctaaagggcg tctaagatca tgtacttctt
    14761 taggaccgtc aacagtgact tgaatatcat ttactccaca tgatattaac gtttgaactt
    14821 tttctttatt taaaagatag ccgtttgtaa tgacactggc cgtatattgt atattgtttt
    14881 ctttacatat ttccaaaaaa tcttccgata tcctaactat ctgcttcatt gcaatcaagg
    14941 gttcaccgcc ataccatgta acattaagag tgtcaagttt actagcattt gttttaacaa
    15001 aattgactat actttgagtt gtttcttcac tcatagtttt gttatgatat tggtctttct
    15061 caaaacagta tacacatcga aaattgcagg ccattgtagg ggcaattgtt agcattaaat
    15121 tagaagattc aaaccgattt tttaagaggt ttacctttac atatgctttt tcattcatat
    15181 tatcttctac gatatagcca cattcgataa gatttttaag ataagtatca ttatttattg
    15241 ccaatccatt gtttgtaagt tcacaaaact gtttatagta ctccggttca agaactgcca
    15301 atgcacctgt tcgagaatta taaagtaccg ttttatcggt attttcaata atgtcattaa
    15361 aaataaagtt atattgcgaa gctttcattt tagccctcct tagaatggat gcggtcccta
    15421 tgtaattatg aatcgattaa ctagtgacaa aattcacata agttttaaaa ataagatgta
    15481 cgctcattct gagttgtaat agcattctcg cagtgcacac tagccaccaa gaatagatgt
    15541 ccatcatccg aaaccggact gaatttaaaa gccatcctac acctttatag tttattcata
    15601 tactttattc tctctggaca atatctatac tagatagctt ttccttctcg gcttttaatg
    15661 tagcataagg caaaaagaaa aaataagctt gtatcctgaa atgcaaaaaa gtccatctca
    15721 acgaccaaat atgtcagctt catgtgagat taatattttt gttacctatt ctaagtaata
    15781 aagaagaacg tatccattcc ctcgcctggg ctacgtcctc tccacagtat aagtatgcat
    15841 ttgaactttt actaacaaaa attccataac ctgatggtaa ttgttttcat atgtaaaaca
    15901 tcacttcgaa tagacttttt ttacaatata ctggatttat ataacatatt tgaggtggtc
    15961 tatttgtttc aagttgctgt ttgtgacgat gatcccgcaa tgcataaaat tttacaacac
    16021 tttttcatgt gtatgtcagt aagtgaatcc ttagatttta atctacaatt ctttttatct
    16081 ggggaagatc taatcaaatc ttacagttca caagagcgat acccctttca tattatcttg
    16141 ttagatattg aaatgaggga attatcggga attgaaactg caaaacttat tcgccttttt
    16201 cctgaccgag aagttcaaat catatttcta actaactatc cagaatacat gctagaaagt
    16261 tttgaagtac aagcatttca atatttactt aaacccctta cttataaact ctttgtagaa
    16321 aagataaata aactatgtca ttatatgcgt tcttcagtat cccactttct gtctgtgaaa
    16381 aataaaactg agcatcttgt attgagacac tctgaaatca tagccatctc aaaaggtgaa
    16441 aacaattaca tccataatga actttgtatt gcaacggatt cacacaacta ttttatttcc
    16501 ggaacgttga aagcggttta tgaacaatta aaatatccgt ttgtgtttat acataggtca
    16561 ataattgtga atttagttca tatacgtaag ttttcagcta cttctgttat tatgtcaaac
    16621 gaacaagaat tccctgtagg tcgttctcac gctaaatcgc ttcgtgaggc gtatgctcgt
    16681 tttataattt ctcgttttca ggaagggtga gttttttgaa tcattgcgtt tacattaatg
    16741 tcacctcgtt ttctaattac tctttatttt tatttagcac aacaaagcaa agtgattttt
    16801 ccaatccaat agttaacctt tttttacttt tcgcctcttt acacttcata cttattacag
    16861 tactagtagt tcattatttt aaaaaaggaa gaaaatacaa gatagggatt gtgtattatt
    16921 ttgtaatatt aataggaaca tcgtttaact tgctcataca ttacggttta ttttctttta
    16981 tgaaacataa tttattcttt ataatgtcaa tcatcagtat tcttggaatg aacgtgatta
    17041 ttgtctttct aacggacaag ttgatagaaa agtcaaacct ctcatgcttt tttcaaaagc
    17101 aaatgctgat gcaagaaaaa cgttataaag aaacaactcg atctcttagt gatatcaaac
    17161 gaagtattca tgatttcaaa aaacagttaa tatttgtccg tgcttgttta caagaacaga
    17221 ggacggaaga gggtgttaat cacatcaacc aaactctaaa aaatatagac tcaccaaaac
    17281 ttcatataac aacaggacat ctcgttattg atgctttggt aaatcatact ttcagcatcg
    17341 ctaataaaag tgggatagct ttcttccatc aaatccatat taacccggca aatattagta
    17401 ttggaagtca tgatctatgt attgtcttag gtaatgtttt cgataatgct attgaagctg
    17461 taatgcagct tcctagaaag aaagagcatt caattcattt ggaaattttc accgataatt
    17521 ttgccctatg gatttatgtt cgcaattcaa aaagtaatta tctcaataca gcattctcaa
    17581 ccaaaacata caattcccct tcaaaaaaac acgggtatgg attacttaac atccagcaag
    17641 tgataaagaa atatggtggt tatttaaata caactattac ggattcgcat tttcaaatta
    17701 cgattatgct cccatgtaat aactcttagg tttgtaaacg ttatggatta agagatattc
    17761 agaataaata aaatgtcggt aatcaccagt cttataacct aaaaaaaagg agtaccctca
    17821 agcctgtgat ggctgaggat actccctttt agtatttatg aatttaccgt ttgtcccttt
    17881 tcttctactt ggatagccgc ccctacattg gcaccagcaa gaataccctt gttcttatta
    17941 ggatacaaag aattcatata agtccgggtt tctgcaacaa caattcccga caagccgagc
    18001 agtgcaatca ggttcggaaa agccatcatg gcgttaaaaa tatctgccag cagccagatg
    18061 gcatcgagct tgatgaacgc gcctccggca accagtacga tgaacagata acggtatggt
    18121 ttaatccact tgaccccaag caaatattca acacagcgtt ccccgtagta gttccagcca
    18181 agtatcgttg tgaacgcaaa taaaataagg ctaatcgtca cgagctctgc tccagccgga
    18241 aaggcactgg aaaacgcatg ctgagtcatc agacctccat catcatttcc actccatatt
    18301 cccgtaacca gcaatgtaaa tcctgtcaaa ttacaaataa tcatcgtatc gataaaaacg
    18361 cccgtcatgg atattagccc ttgttctgcg ggccatttcg tcttagctgc tgctgctgcg
    18421 attggcgcac ttcccaaacc agcttcattt gcaaagatcc ctctggcaac tccgcttcgc
    18481 atcgccagca taatcgtggc tccggcaaat ccacccgtcg cagatgttgt cgagaaagcc
    18541 ccttgtaata ctagtgcgat cgcatgagga agctctcctg caaacttaat gagtacgatt
    18601 aaacaaacca cgatatagag ccccgacatg aatggaacaa tctttgtgga taccttggcg
    18661 atacttttga gtcctccaat cgtaacaaca gccgtcaaca cggaaataat gattgctgta
    18721 actactgttg gcacgccaaa gctactttcc gtagaagaaa cgatagcctt tacttgcgga
    18781 aaagtaccga ttccaaatag tgctacaaga ataccagaaa aggcaaacaa catcgccagc
    18841 ggcttgaaac ggcggccaag cccgttttca atataataca tcggtccacc cgaaaattgt
    18901 ccgttccggt ctttaacacg gtatttaacg gataatagcc cttccgcata tttggttgcc
    18961 atcccgaaaa aagctgcaac cagcatccag aataatgaac cgggcccacc cagtttgatc
    19021 gctgttgcga caccgacgat acttcccgta cctacagtag ctgcaagtgc cgtactcaat
    19081 gctccaaagc tactgacatc cccgctgcct tcgtccggcg ctttaccaat tagcttgagc
    19141 gctaagggca atcgaataat ctgaagcatc ttcagacgga tcgttagcca caacccagtg
    19201 cccatgacga gaattagaag cggcgctccc cacatccaac tgtcaatcgt ttctaacaca
    19261 tgtaccaaat tcatttcaac ccgctccttc agcatagtag aaaacaaaaa agagtcaaat
    19321 ctgttgattc gactcttgga gaggttaaag gcacgaaaaa atacaaccat cttgtgcagg
    19381 atttcacctc taaaagctta taaaaagcct agggctatcc ctgtcacagg ttattcgcgt
    19441 ctctgtcctt ttgcctgaga gtttaagcag atgtgatctg cggtgcacct tcggcgccca
    19501 attaagggtc tctccagagt tctgtccgtt tacggtccct gctcgttgct gtaaatcagc
    19561 ctaagcacct gagagttttg ccccttcggt tggaactttc attccatctc ccgcaaacat
    19621 caaccagaca tatgaaattt ttattcatta tacagaaaaa tttcagctta ttacaagtga
    19681 aaaatttgtg aagccctctg aaagaatcaa tagagtgtct atacaaaaag cgggtacagc
    19741 agattgcatc ctgaggattt tctctgctgt acccgccaaa acgatatgga attacaattc
    19801 ttcaccgttg gttgctatca catttttata ccagttaaat gagtcctttt tggagcgttg
    19861 aagcgttccg ttaccgtcat catccagatc aacgtaaata aatccgtagc gcttggacat
    19921 ttcggacgta gacatgctca caaggtcgat aggtccccaa ctggtgtaac caatcagatc
    19981 aacaccgtca gcaatcgctt ccttcatttg ggcaatatgc tgacgcaagt aatcaatgcg
    20041 atacgtgtca tgcacagagc cgtcttcttc taccttatca tacgcaccca ggccattttc
    20101 cacgatgaac agtggctttt gatagcgatc ataaaacgta ttcagtgtaa cacgcaggcc
    20161 gatcggatcg atctgccatc cccagtcgga agactgcaga tacggatttt tcacaccgcc
    20221 tatcaggttc cctgctgcct tttcgccttc tggccctgcc gatacggtca aggtcatata
    20281 gtaactaaat gagataaaat cgaccgtgtt atttttcaaa atttcggcat cgccgggttc
    20341 tgtctggatc acaatattat tttcttcaaa atagcggttc atatagttgg gatattcccc
    20401 acgagcatgc acatccgtaa agaacaagtt catttgattt tcatgctgtg ctttcaggat
    20461 atcttctggg ttacacgtat gtgggtagct ttcaatgcgg gccagcatac agccgatctg
    20521 agcgcccgga atgatctcat gtccccgttt ggtcgccaat gcacttgcta caaattgatg
    20581 gtgcaatgct tgatatatcg cttgttgctt gttttctaca cggtcaataa ccacaccgcc
    20641 gcctgtaaac gggctcatag tcatgacatt aatttcgtta aaggtcagcc agtattttac
    20701 tttatcctta tagcgtgtaa ataccgtttc ggcatatttt acgtaatgat ccacgacttc
    20761 gcgtcccaac cagccattat atttctgtgt caaacctagc ggtgtttcat aatgcgacag
    20821 tgttaccaaa ggctcaatac catacttgcg cagctcatcg aatacattgt cgtagaattg
    20881 caatcctgct tcattcggct cggcatcata tccattcggg aaaatccgcg accagtggat
    20941 ggacatccgg aatactttaa agcccatttc tgcaaacaag gcaatatctt ctttgtagtg
    21001 gtggtaaaag tccacacctt cacgctttgg aaaacgggcg tttaccttcc ctgccaagat
    21061 gtcctccagt cgttcggacg aaatttctat agcatgatcg ttcttacgtt ctgatttagg
    21121 tacataggct atcatgtctg cgctggatag accttttcca tctacgtcaa aagcaccttc
    21181 caattggttg gctgcagttg ccccgcccca gaggaagttt ttcgggaatc cttttagcgt
    21241 cttcgtcatg gtatgaaaac ctctttcctt aatttaatgt tttcacttta gtcagtaacc
    21301 cgtcaggtgc tgcaatgcga atccataact aacggtaacc gttctccttt gaaatgcatc
    21361 gacagatgct ttaaaataga cataatgccc tcataaagca tcctaattgt tgtaacgcgt
    21421 ttcatgtcaa gtattttttt ctcaggtgag gagaagcatc atgtcgaatc ttgatcaaat
    21481 tgcaaaactg gcgggctttt ccaaagctac ggtatccaga gtgttaaatc agtcccccca
    21541 tgtaagtcac gaaaccagag ctaaaatttt aaaaatcatg caggaattag attatgttcc
    21601 taatcggaat gcgatctctc tatccaaggg tcagacgctt cagattggta tcatcacttc
    21661 aactatcaat gaaattgtgc tggcatttct ggacagcttt gtggaaatcg caggccaata
    21721 tgaattccaa accattattt atacttcggg agaagacaaa aagaaagagc ttcaagcttt
    21781 cgaggattta aaaagaaaaa gagtcgatgc gctggtcatc atttcctgcg tgaatgacac
    21841 tgattttttg agtacctatt gtaaatatgg accgatcgtg gcatggcaac gtatggagca
    21901 taccgatatt cgctccgtcg ctatggatca atatgaagga tacatgttag cattaaaaca
    21961 tttgatacaa aaaggctata cacgtatagc caatgctttt ggtcgtccga gcagcatcaa
    22021 tactcacagc agacaacgag cctatgagca gatcatgagt gaacacaatc tgccggtgct
    22081 gccacactgg aactattctt ctatttataa cattcgtgat ggcgaacagg tcgtgcgcaa
    22141 tttgttacag catcgtgagg aatttccgga ggctatcttg tgtgctaacg attatgtagc
    22201 agtgggcatt ctctgcgaag cgcgcagaca attgctgagg gtaccggaag acttggcgat
    22261 tgttgggttt gataacacgg agctggcgca caccatgggc attacaacgg ttcaaaatcc
    22321 cattatggct caggcacaaa atgctttttt catgctttcc cctcagctga ttggacgcca
    22381 aatggagctt cattcgctag aatacagcct catagagcgt acgactactt aagggcacaa
    22441 ttgacttgca aattaggcaa atgggccttg atatgaaata ttttttgtcg aaagagaata
    22501 aaatatgttg aaatcgcttt tttttgtgct acaatagcac tatatcgaag gattgtgacc
    22561 ggtgatgcgg gcaatgcctg agttcaattg agtgctattg ctaacaatag tgttgaattg
    22621 tgcttgggca ttttttattg gtaaaggatg ggagggggaa cttcaatgat tattgagaag
    22681 gtgctcaata acaacgtcct gttgactaaa aacgataaag gcaaagaggt catcgtcatg
    22741 ggaagaggta tttccttcaa aaaggtggct ggggaccaag tcgatgatca taaaatagat
    22801 aagattttca tgttaaatga aaacgagttc acggccagac taactgagct gctaaacgat
    22861 attcctgtgt ctcatctgga ggtcgtgaat gaaatcgtga cccatgcagc cgaagtgctg
    22921 gatacggagt taagtgataa catttattta acattgaccg accatattca ttttgccata
    22981 cagcgggaag aaaaaggatt ggcactcaaa aacgcgatgc tgtatgaaat taaacgcttt
    23041 tacaaaaaag aatttgcagt tgggctggat gctctacaaa aaattgaaaa tacgctcggt
    23101 gtaaaattgg gcgaagacga agcgggattt atcgcattgc atatggtgaa tgcgcggatc
    23161 gacggtaacg aaatgaaggc tacactaaaa atgactgaga ttgtccaaca catattgaat
    23221 attattacgt atcattacgg gattgtgctg gatgagtctt cttttagcta ttcgagattt
    23281 ttgacccatt tgcaatattt tgcaatgcga gtgattcgca aagaggttat tcacagtggt
    23341 gaagaatttt tgtacaacca ggtaaagcaa acatataccg aggcttttgc ttgtgcccaa
    23401 aaaattaatg agtatctgga aaaaacatat gatcaatatt taagcaaaga tgagtatgta
    23461 tatctaacga ttcacattca tcgggtaact gagcgtaata acatatcagg ctaaaaactt
    23521 tatatcctca tcgttcatgg attgtgactg gtaaggcagg caaaacctaa actgatggtg
    23581 aaatcgacgt tcccttatag gaggagtgcg cagttttcac cacgagttta ggtttttctt
    23641 gtttacaagt ttaaaaagat gcacgccggc gcatctcagc aacaaatgta aacggtaaat
    23701 cctatcagta gcaagaataa cacttaagga gttctgaaca tgagtgataa agagctatcc
    23761 aaaaaaatag tgactctcgt tggcggcgaa aagaatgtca attcggtatt ccattgcgct
    23821 acacgcttga gatttaaatt aaaagatcgc acaaaagcag acaaagctgc actggaagca
    23881 acacctggtg tcattacagt ggtggaaagc agtggccagt tccaagtggt cattggtaac
    23941 aatgtaggtc aggtctttga gcatatgatg gcagaaacaa atctgcagga tgcagataat
    24001 ccaaatgcga aaaaagaaga atcttccgaa aaaacgaatt ttcttggcaa agcggtcgat
    24061 atcatttcca gcattttctc acctctcttg ggtgctcttg ccggagctgg tttgctcaaa
    24121 gggattatgg ccttaattgc gtcgctccat tggattgata ctgcaagcgg tacgtatctc
    24181 attctgaacg ccgcttcgga cagcgtgttt tatttcttgc ctatattcct agctattaca
    24241 tcgtcccgta aatttaagac gaatgctttt gtatcggtcg cagttgctgg agccctcgtc
    24301 tatccggatg ttattgcagc ggtggaccat ccggcaaaac tggcttttct cgggattcca
    24361 atcattctga taaaatatag ttctagcgta atcccaatta ttctcgcggt atgggtacag
    24421 tcctatgtgg aacgttggtt taattccttt gttcatcaat cggttaaaaa cattatcgtc
    24481 cctatgctat cactgctagt tgttgttccg ttgacgtttt tggcctttgg tccagtcggt
    24541 aacctgatca gtcaaggctt ggcgaacggt tttacatggg tgtacaattt aagcccattg
    24601 attgccggag ctgttgctgg ggcattctgg caagtatttg ttattttcgg cgtacattgg
    24661 ggcttcgttc ctattatgct gtccaatatt caaacattgg gttatgacac gatgcttcca
    24721 atgcttacag cagccgtact ttctcaagca ggtgcaacac tgggggtatt cctgaaatca
    24781 cgaaatactc aaatgaaagc tttggctggt tcttctacac tggcagctgt attcgggatt
    24841 actgaaccta cgatttatgg tgtaactttg aaattgaaaa agcctttcat ttacgcttgt
    24901 atttctggtg gtatcgatgg cgctattatc gcttccggcg gagcaactgc aaaatccttc
    24961 tccctgccta gtttactggc gttgccaact tattttggag ctgggttctt gtgggttgtt
    25021 atcggcttac tcgttgcctt tgtacttgca gttgtattgg ttatgatttt gggctttgat
    25081 gatccaaaag aagaagctgc aaaaacagaa acagcacccg taaaaaaaga agtagccatc
    25141 gaaaaagaaa tcctcgtaag tccgctgcaa ggtaaagtgc tgccattgga acaatcttct
    25201 gatgttgctt ttgcttcagg cgctatgggg aaaggaatct tgatcgatcc tacagagggt
    25261 gtgctgactt ctccggttaa cggaacgatt acgacagtat tcccgaccgg acatgccatc
    25321 ggtattactt ccaatgacgg agcagaaatt ttgattcacg ttggtgttaa tacagtgaag
    25381 ctgaaagg
//
