LOCUS       NZ_CP061870            22954 bp    DNA     circular CON 25-MAY-2024
DEFINITION  Bacillus subtilis strain FX-1 chromosome, complete genome.
ACCESSION   NZ_CP061870
VERSION     NZ_CP061870.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4266037)
  AUTHORS   Huang,S.
  TITLE     Identification and cellulase producing ability analysis of Bacillus
            subtilis FX-1 based on Genome-wide data
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4266037)
  AUTHORS   Huang,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-SEP-2020) Technology Innovation Center for
            Exploitation of Marine Biological Resources, Third Institute of
            Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen,
            Fujian 361005, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: FALCON v. 0.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 490.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022647025.1-RS_2024_05_25
            Annotation Date                   :: 05/25/2024 05:42:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,743
            CDSs (total)                      :: 4,620
            Genes (coding)                    :: 4,349
            CDSs (with protein)               :: 4,349
            Genes (RNA)                       :: 123
            rRNAs                             :: 11, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 271
            CDSs (without protein)            :: 271
            Pseudo Genes (ambiguous residues) :: 0 of 271
            Pseudo Genes (frameshifted)       :: 166 of 271
            Pseudo Genes (incomplete)         :: 103 of 271
            Pseudo Genes (internal stop)      :: 45 of 271
            Pseudo Genes (multiple problems)  :: 38 of 271
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:12:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 463961
            Orig. end                         :: 486915
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP061870.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22954
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..22954
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="interleaved"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22954
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12954](+)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12954
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     protocluster    235..21467
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10234:11467](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      10235..11467
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
     gene            373..915
                     /gene="adaB"
                     /locus_tag="IE382_RS02535"
                     /old_locus_tag="IE382_02525"
     CDS             373..915
                     /codon_start=1
                     /gene="adaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388063.1"
                     /locus_tag="IE382_RS02535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02525"
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="WP_041335168.1"
                     /transl_table=11
                     /translation="METKNKPTLYWSLLMFKDWNFYIASTLKGLVFVGSQNKPIEELFE
                     WAKKRFPGSLLVEDDDKLEPYAVEITQYLEGKRKNFTVPVEYAGTQFQLAVWNALCEIP
                     YGQTKSYSDIANEINKPAAVRAVGAAIGANPVLITVPCHRVIGKNGSLTGYRGGFEMKT
                     LLLDLEKRASSEMDVPH"
     gene            1435..2952
                     /gene="ndhF"
                     /locus_tag="IE382_RS02540"
                     /old_locus_tag="IE382_02530"
     CDS             1435..2952
                     /EC_number="1.6.5.9"
                     /codon_start=1
                     /gene="ndhF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388064.1"
                     /locus_tag="IE382_RS02540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02530"
                     /product="NADH dehydrogenase subunit 5"
                     /protein_id="WP_041352202.1"
                     /transl_table=11
                     /translation="MLVSLSLSSLLTLFFIMLMASGISGLLFLHPRVPLSFVRIHIGIL
                     ALPLLVSLLILANSGVSGNVGPWHLDSLACLMTFFVLAIGFIIQRFSVRYLMGDRSYRK
                     YFTLFTFTTGAASMTWLSGDLRLMVLFWGATLVGLTLLIRLNSAWQVASEAAKISGRLF
                     LLSWFSLFFAMMWLFHATGQWQLSLVVTNESLAGLGEWERTGIQLLIVLAVIIPAAQWP
                     FQRWLVESIVAPTPVSAIMHAGLVNAGGIILTRFSPLFHGGIASIILLLLAGISVMIGT
                     GISLVQVDYKRQLVGSTIGQMGFMLIQCALGAYIAAIIHLILHGLFKATLFLQAGSAVG
                     RHEVSARTNERTSYLWVMAGRILSLVIGVAFWLAAPGEGYQFISALILGWSLSVSWTQL
                     VAFGEGRIGRIAGLTVLGGAALVYFIIHHLFYKWLHTTIFQSVQPPMSAVMIVVCLLLF
                     GSALGTWVARHRSSVFFAVLYLWLVRLGEAKPKSVESHPDYLKQYIS"
     gene            2967..5582
                     /gene="ybcC"
                     /locus_tag="IE382_RS02545"
                     /old_locus_tag="IE382_02535"
     CDS             2967..5582
                     /codon_start=1
                     /gene="ybcC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388065.2"
                     /locus_tag="IE382_RS02545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02535"
                     /product="YbcC family protein"
                     /protein_id="WP_041352204.1"
                     /transl_table=11
                     /translation="MGITSVLTKDNVKKIDTDIDVQERDLNVFITSASRVIAPLWPIST
                     FAARNPWMGLENQPFDQVASWLKNTRDVDIYPSASMIRSAKNKGEIDEDFVEMGLQRWL
                     DSHSYHIPRDVAERFCHAALKLDPLPSDLLSSHELEKLVGECSGLDHIENVFMQPLSSY
                     IENQDGERLVNILDHHVIKWSKLYLDDSQAGWTMPNREEGFYRAWQHLIQYDPALSKKQ
                     RERVKGWPKEAHLALQEALFALEIPESEIQTYLEGHLLSLPGWAGMMLWRSQQSSHEHA
                     LLTEYLAVRISMEWALIKPYLPLTNERSKKTISIAPLIAAWIHWGGLTLEEWSQMTAIE
                     QNEYLSFAYSFDEKLRKKLWLEAWEQTYTDRLSQKIISKQRETGHKKSALAQLAFCIDV
                     RSEPFRRQLEKEGPFETIGIAGFFGVPIATCELGSKHSHASLPIIQKPQNKIKEFAGED
                     VFKKYNQRKQAIHSLSHTFKTMKQNALSSLLLPELSGPWLTLQMAARSFVPRKAGRFIR
                     NLREAWLRKPDTKLSLHHDATEAEIPVGFTDEEKVNYARQALKMMGLTENIAPLVVICG
                     HGSQSTNNPYSAALDCGACGGAAGGFNARVLAALCNLSEVREALLTEGIKIPEDTVFAA
                     AEHNTTVDELHWLYVPELSEAAQEAFEQIEAVMPKVRHHVNAERLAQLPNFQSKLKNPK
                     AEANRFAEDWSEIRPEWGLARNAAFIIGKRELTQDCDLEGRAFLHNYDWKQDESGELLA
                     NIIAGPGTVAQWINLQYYASTVAPHYYGSGNKATQTVTSGLGVMQGNASDLLAGLPWQS
                     VMESDHEAYHSPLRLLILIQAPREYVERLLNHDSAFLQKVQNGWVRLANIDPEGCWESW
                     "
     gene            5659..6186
                     /gene="ybcF"
                     /locus_tag="IE382_RS02550"
                     /old_locus_tag="IE382_02540"
     CDS             5659..6186
                     /codon_start=1
                     /gene="ybcF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388067.1"
                     /locus_tag="IE382_RS02550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02540"
                     /product="carbonic anhydrase"
                     /protein_id="WP_041339978.1"
                     /transl_table=11
                     /translation="MNVIQNKKVLFLTDIENGLEPILQEATNTSAENMLTIQSYGAGIS
                     HPYGEIMRSVIFAIYQEDVEEIFVVGTKDKKTSAGNGLTQLETMKDKIQTLDYLFQNCK
                     PEFLGGTVDEWLNENSSDTIEKSVDMIRHHPLVPSYVKVRGLFVHHKDGKPSIVEVPDV
                     KTGQALPDHCLS"
     gene            6250..6540
                     /gene="ybcH"
                     /locus_tag="IE382_RS02555"
                     /old_locus_tag="IE382_02545"
     CDS             6250..6540
                     /codon_start=1
                     /gene="ybcH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388068.1"
                     /locus_tag="IE382_RS02555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02545"
                     /product="DUF6407 family protein"
                     /protein_id="WP_015252954.1"
                     /transl_table=11
                     /translation="MSANLTDFVTKTIEDMNSFDRENMECMKKLIRKAIDFYHLKSYEE
                     VEETHSGNVRFLHVHSMMEENMLSKMIVVTRNGKTDLDIEGVYEGYVVREY"
     gene            6598..6972
                     /gene="ybcI"
                     /locus_tag="IE382_RS02560"
                     /old_locus_tag="IE382_02550"
     CDS             6598..6972
                     /codon_start=1
                     /gene="ybcI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388069.1"
                     /locus_tag="IE382_RS02560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02550"
                     /product="DUF2294 domain-containing protein"
                     /protein_id="WP_017694955.1"
                     /transl_table=11
                     /translation="MKKSKGSIESEISKSITKWEKDYLGRGSVSVKTDILRDMIIVNLK
                     GILTPAEYVVCGSKEGMLSIKQTRSELVESGIEGLKDIILKITGEKVKSFHTDLSSRTG
                     ERVMVFKLCNDLEKNLEKIL"
     gene            7469..7771
                     /gene="ybzH"
                     /locus_tag="IE382_RS02565"
                     /old_locus_tag="IE382_02555"
     CDS             7469..7771
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="ybzH"
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097670.1"
                     /locus_tag="IE382_RS02565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02555"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_003234907.1"
                     /transl_table=11
                     /translation="MEPIEVFKALSNESRLQILQWLKEPDRHFAPHEGIDMNTIGVCVS
                     QITDKLKMTQSTASQYLTILLRAGLIKAERIGKYTYYKRDEEAIGKLADFLKTEI"
     gene            7898..9070
                     /gene="ybcL"
                     /locus_tag="IE382_RS02570"
                     /old_locus_tag="IE382_02560"
     CDS             7898..9070
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybcL"
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388070.1"
                     /locus_tag="IE382_RS02570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02560"
                     /product="MFS transporter"
                     /protein_id="WP_152425310.1"
                     /transl_table=11
                     /translation="MSNTWKIYILAIVSFLVGTSEYIISGILDQIAHTLGITLAAAGQF
                     ITIFSLVYALSTPVLMALTASMDRRKLMMYALGLFVFGNVLAFVLPGYGWFIAARIIMA
                     MGAGVVVVTALTIAAKIASEGKQGSAIATVVMGFTASLIIGVPLGRMIPVALGWKSVFG
                     AIALLGLIAMVVIFFTLPHTEGDKPVPLLQQLALFKKRKVAMGLSITFFWLGGYSVAYT
                     YLSPYLLNISGINGNLLSGVLLIFGIASLVGSKFGGYSTDKWGVPFTLVGGMTLHIVTL
                     ILLSLVTHSYIGVLVILILWSFAAWSTGPTQQFHLATIEPEMSGVLLSMNQSMMQFAMA
                     VGAGIGGVFVENVSLASITWVGALGVMIAIIASLLIFNSQPKQALKDINQ"
     gene            <9171..9529
                     /locus_tag="IE382_RS02575"
                     /pseudo=""
     CDS             <9171..9529
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003223659.1"
                     /locus_tag="IE382_RS02575"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="glutamine--fructose-6-phosphate aminotransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="VCVEGALKLKGIS"
     gene            10001..10168
                     /gene="skfA"
                     /locus_tag="IE382_RS02580"
                     /old_locus_tag="IE382_02565"
     CDS             10001..10168
                     /codon_start=1
                     /gene="skfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: TIGR04404"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388072.1"
                     /locus_tag="IE382_RS02580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02565"
                     /product="sporulation killing factor"
                     /protein_id="WP_009966416.1"
                     /sec_met_domain="TIGR04404 (E-value: 4.8e-37, bitscore:
                     123.7, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRNQKEWESVSKKGLMKPGGTSIVKAAGCMGCWASKSIAMTRVC
                     ALPHPAMRAI"
     aSDomain        10235..10537
                     /aSDomain="Other_Sactipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a sactipeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE382_RS02585_Other_Sactipeptide_rSAM
                     _RRE.1"
                     /evalue="1.70E-16"
                     /identifier="RREFam021.1"
                     /label="IE382_RS02585"
                     /locus_tag="IE382_RS02585"
                     /protein_end="101"
                     /protein_start="0"
                     /score="51.4"
                     /tool="antismash"
                     /translation="MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAF
                     LLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSL"
     gene            10235..11467
                     /gene="skfB"
                     /locus_tag="IE382_RS02585"
                     /old_locus_tag="IE382_02570"
     CDS             10235..11467
                     /codon_start=1
                     /gene="skfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388073.2"
                     /locus_tag="IE382_RS02585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02570"
                     /product="sporulation killing factor system radical SAM
                     maturase"
                     /protein_id="WP_003234902.1"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     2.7e-14, bitscore: 51.4, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 8.1e-31, bitscore:
                     105.3, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.9e-21, bitscore: 74.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5.2e-06, bitscore: 24.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 5.3e-05, bitscore: 21.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAF
                     LLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSLDSY
                     LPISCTLQLTNACNLSCSFCYASSGKPYPEELSSEQWILVMQKLAAHGVADITLTGGEA
                     KLIKGFKELVVVASSLFTNVNVFSNGLNWRDEEVELLSHLGNVSVQISIDGMDNTHDQL
                     RGRKGGFKESMNTIKKLSEANIPVIVAMTINESNADEVSDVVEQCANAGAFIFRAGKTL
                     SVGRATEGFKALDIDFEEMVQIQLREARHKWGDRLNIIDWEHEESSFTTDFCTPGYLAW
                     YIRADGYVTPCQLEDLPLGHILEDSMADIGSPARLLQLKCEAKNCKCIGKIELSEPDLP
                     FQKEVKAGIQE"
     gene            11464..12954
                     /gene="skfC"
                     /locus_tag="IE382_RS02590"
                     /old_locus_tag="IE382_02575"
     CDS             11464..12954
                     /codon_start=1
                     /gene="skfC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: skfc"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097671.1"
                     /locus_tag="IE382_RS02590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02575"
                     /product="sporulation killing factor biosynthesis protein
                     SkfC"
                     /protein_id="WP_041335176.1"
                     /sec_met_domain="skfc (E-value: 1.4e-286, bitscore: 949.3,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Abi (E-value: 1.2e-12, bitscore: 46.1,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSLSLVFWSILAVVGLLLFIKFKPPTIASLLLSKDEAKEISIQF
                     IKEFVGIDVENWDFYSVYWYDHDTVNKLHHLGILKKNRKVLYDVGLVESWRVRFVHQNQ
                     SFVVGVNANREITFFYADVPKKTLSGKFEQVSPETLKQRLMASPDGLWSRANMTGTGKK
                     EEDFREVSTYWYIAEAGDIRLKVTVELQGGRISYIGTEQEILTDQMSKVIRDEQVESTF
                     GVSGMLGSALAMILAILILVFMDVQTSIIFSLVLGLLIIIFQSLTLKEDIQLTIVNAYD
                     ARMSVKTVSLLGILSTLLTGLLTGFVVFICSLAGNALAGDFGWKTFEQPIVQIFYGIGA
                     GLISLGVTSLLFNLLEKKHYLRISPELSNRTVFLSGFTFRQGLNMSIQSSIGEEVIYRL
                     LMIPVIWWMSGNILISIIVSSFLWAVMHQVTGYDPRWIRWLHLFIFGCFLGVLFIKFGF
                     ICVLVAHFIHNLVIVCMPLWQFKLQKHMHHDQPKHTSL"
     gene            12973..13695
                     /gene="skfE"
                     /locus_tag="IE382_RS02595"
                     /old_locus_tag="IE382_02580"
     CDS             12973..13695
                     /codon_start=1
                     /gene="skfE"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388077.1"
                     /locus_tag="IE382_RS02595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02580"
                     /product="sporulation killing factor ABC transporter
                     ATP-binding protein SkfE"
                     /protein_id="WP_041335180.1"
                     /transl_table=11
                     /translation="MQLMQVQNLSKCYRNGDGVEHLSFSIQRGEIVALLGPNGAGKTTT
                     IRCLTGLYKPDKGDILIEGSPPGHINVQKKVALIPDQPYLYPALTAAEHIQFRARGYHP
                     GKKDVKERVYHALKEVHLEEKANQLCGQLSRGQKQRVVLAGAIVQDALLYILDEPTVGL
                     DIPSKQWLSNWLKTKTDQECSAFVSTHSLEFVLETADRVILIRDGKLMQDLYVPQFEEE
                     QAEWRKEVIRLLGEWSDE"
     gene            13688..15103
                     /gene="skfF"
                     /locus_tag="IE382_RS02600"
                     /old_locus_tag="IE382_02585"
     CDS             13688..15103
                     /codon_start=1
                     /gene="skfF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019257319.1"
                     /locus_tag="IE382_RS02600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02585"
                     /product="sporulation killing factor system integral
                     membrane protein"
                     /protein_id="WP_017694959.1"
                     /transl_table=11
                     /translation="MNNIISFLWLQSKRRFVSQGQEKKMPFLIMLLFVGAIGFQVSFVS
                     RSTTWDMSIAGWVLTGVFILYTAFGLFSNRLPSQMADIIWLYGTATSFSKVVYSVLFFS
                     VTWKALLWIISAIFGDVLIVLLSGEHINLLGRSIIFIGLFFIAEVWLMSVSCARTVKKM
                     KRVYVSVFLLMLGIYSICLYQFFFLQHSSGIWESIARFISGVGLVFDTLSPLYVVVFIG
                     IITVSFMTIAFTSRQVEMRESLVKEAEFWEEFQERQFGSGQIIQKPKTTWWGLQGLNGI
                     WSFLWLELLLFKKYLFFHSIHTVMLSGVFYVVIFMYPEWFYLLFFLIVSAVMLSSYYSG
                     IVRHSQSGTLHLFPGALWKKIIILELTNTVWLYILYCVSITFMAVGNLVYWYIYGLGIY
                     IWFMTIRLFAFTHTNRNDIKLSLPQYYKSFFMALGLSGICLYVIHLLTADWYTLVVVVC
                     IGSLSWCLFYRFR"
     gene            15150..15665
                     /gene="skfG"
                     /locus_tag="IE382_RS02605"
                     /old_locus_tag="IE382_02590"
     CDS             15150..15665
                     /codon_start=1
                     /gene="skfG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388079.2"
                     /locus_tag="IE382_RS02605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02590"
                     /product="sporulation killing factor biosynthesis/export
                     protein SkfG"
                     /protein_id="WP_003234897.1"
                     /transl_table=11
                     /translation="MNSNGDKLSLSVQNLANTNEITIVQAIGELKKSGKDAIPVLVEAL
                     KEEGSLCNIAAAVLGEFGEDASEAAEELSCLLKSHAEDTRMAAAISLMRIGKPSLPFVI
                     KIAQESEGQSCFWASWCIAWIDPSCIEPKMYKCLKYEHEHPSGIVAPFAAEEALGKLIA
                     FQLKDKED"
     gene            15670..16095
                     /gene="skfH"
                     /locus_tag="IE382_RS02610"
                     /old_locus_tag="IE382_02595"
     CDS             15670..16095
                     /codon_start=1
                     /gene="skfH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388080.2"
                     /locus_tag="IE382_RS02610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02595"
                     /product="sporulation killing factor biosynthesis/export
                     protein SkfH"
                     /protein_id="WP_003246390.1"
                     /transl_table=11
                     /translation="MKDEQMLTEWPSHLPWLNQSQNDFTFPSDTYLLLYFWSMSCPNCH
                     QLTDKVLQDIKDMNVKVIGVHVPYIEEEKSMEVVLTYALDRGLAIPIVLDQNYEIVTTC
                     HVQGIPSFCLLSQYGQIITKTMGDVGWDKMLKKIAGL"
     misc_feature    15688..15703
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.76"
                     /tool="antismash"
     gene            16344..17321
                     /gene="ybdG"
                     /locus_tag="IE382_RS02615"
                     /old_locus_tag="IE382_02600"
     CDS             16344..17321
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybdG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388081.2"
                     /locus_tag="IE382_RS02615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02600"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_041335183.1"
                     /sec_met_domain="PF00561 (E-value: 6e-07, bitscore: 27.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLWKVLKIVFVSLAALVLLVCVSVFIYHHFQLNREAALLKEKG
                     TLVEVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAGYG
                     YSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKAIIA
                     MDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDEEKEI
                     YKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKYAIQNR
                     KDYEAFAAQFNTADIKELRETHSIYLYQPDQIYKLSMEFMRKVR"
     gene            17323..17994
                     /gene="ybdJ"
                     /locus_tag="IE382_RS02620"
                     /old_locus_tag="IE382_02605"
     CDS             17323..17994
                     /codon_start=1
                     /gene="ybdJ"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388082.1"
                     /locus_tag="IE382_RS02620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02605"
                     /product="two-component system response regulator YbdJ"
                     /protein_id="WP_015382624.1"
                     /transl_table=11
                     /translation="MKGYHILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQK
                     VDLVIMDVMLPGEDGYQMSAKIKELGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKPFD
                     PRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYLYEN
                     RDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLNTVVK
                     K"
     gene            17991..18977
                     /gene="ybdK"
                     /locus_tag="IE382_RS02625"
                     /old_locus_tag="IE382_02610"
     CDS             17991..18977
                     /codon_start=1
                     /gene="ybdK"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003234894.1"
                     /locus_tag="IE382_RS02625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02610"
                     /product="two-component system sensor histidine kinase
                     YbdK"
                     /protein_id="WP_017694961.1"
                     /transl_table=11
                     /translation="MKLKTKYQLLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMP
                     FHRSFAYPAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVK
                     RADEIGELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLE
                     DQCHGQAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDY
                     LYSMSGIELHYKAADQDVIWMSNALWMQRLFDNIFQNTLKHSKAEKMEVTIEHDNVFIR
                     DDGIGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDSGTGFLFSKE"
     gene            19036..19295
                     /locus_tag="IE382_RS02630"
                     /old_locus_tag="IE382_02615"
                     /pseudo=""
     CDS             19036..19295
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097672.1"
                     /locus_tag="IE382_RS02630"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02615"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNSICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAARA
                     KEDTTTVMAAVIVTNAGATAAVNPKKFLFRFWDKGFFM"
     gene            complement(19280..20050)
                     /gene="ybdM"
                     /locus_tag="IE382_RS02635"
                     /old_locus_tag="IE382_02620"
     CDS             complement(19280..20050)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybdM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388085.1"
                     /locus_tag="IE382_RS02635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02620"
                     /product="protein kinase"
                     /protein_id="WP_017694962.1"
                     /sec_met_domain="Pkinase (E-value: 4.8e-32, bitscore:
                     109.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTDI
                     LTQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLNSIHHPQIPGFIDEFIIDGQAYYVMQF
                     IEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDGRLC
                     LIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEELTLTK
                     EVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT"
     gene            complement(20136..20993)
                     /locus_tag="IE382_RS02640"
                     /old_locus_tag="IE382_02625"
     CDS             complement(20136..20993)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388086.1"
                     /locus_tag="IE382_RS02640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02625"
                     /product="hypothetical protein"
                     /protein_id="WP_017694963.1"
                     /transl_table=11
                     /translation="MVKKWLIPFAVMLSVLFTFTYSASAVGVTAITGNNSFDTAMPIGY
                     WKYKNIDTTILEAGQDEAYFTFTANKGEKVYVRSTYQSAYTGMKIEIYDKNRIPVSQGT
                     EVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQFSG
                     IAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHLIMTS
                     ENNEWRRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKIDYEYDV
                     TKQF"
     misc_feature    21050..21059
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            21125..22309
                     /gene="ybdO"
                     /locus_tag="IE382_RS02645"
                     /old_locus_tag="IE382_02630"
     CDS             21125..22309
                     /codon_start=1
                     /gene="ybdO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388087.1"
                     /locus_tag="IE382_RS02645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IE382_02630"
                     /product="DUF4885 domain-containing protein"
                     /protein_id="WP_041335187.1"
                     /transl_table=11
                     /translation="MRLNRQFIRTQLMAQNILSKNAPAKRENATENPAAVLEKAYSRLK
                     SQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESDIR
                     IKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEWLFK
                     GKAQNYNLQDAVFRNVTFHVEVEAENEKVYQRGQVNQQLQVLLNRNNIYIPEGTELTFT
                     ITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSTQFSEEAYQKYQ
                     AAREMYEVTGYQLKDLEVIDGRYITPDGRDLLDVYKEELEKDPVQKQTASYAISYYRSE
                     LSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGVNY"
     misc_feature    22370..22384
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.38"
                     /tool="antismash"
     misc_feature    22390..22403
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.64"
                     /tool="antismash"
     misc_feature    22849..22863
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
ORIGIN
        1 cttgtaaacg ttgcaagccc actaatgaaa aaatgcctga tagcgagtgg gttgatttaa
       61 ttactgaata cattgataaa aatttcacag aaaaattaac gctagaatcg ttagcagata
      121 tttgtcatgg gagtccgtat catatgcatc gaacatttaa aaagattaaa ggcattacgc
      181 tggttgagta tatacaacaa gttagagtac acgtggctaa aaagaatttg attcagacaa
      241 ataaatcgat tggagatatc gctatatgtg tgggtatagc taacgcgcct tattttatta
      301 ctttatttaa aaagaaaact ggacagacac cagcacaatt tcgtcaaatg agtaaaatgg
      361 aggaaacgta caatggaaac aaagaataaa ccaacccttt attggtcttt actaatgttc
      421 aaggattgga atttttatat tgcttcaact ttaaaggggc ttgtgtttgt aggttcacag
      481 aacaaaccaa tcgaggaatt gttcgaatgg gctaagaaac gctttccagg aagtcttctt
      541 gttgaagatg atgataagct tgaaccctat gctgttgaaa tcactcaata tctagaagga
      601 aagcggaaaa actttactgt tccagttgag tacgccggta cgcaatttca gctagccgtc
      661 tggaatgcac tttgtgaaat tccttatgga cagacgaaat cctattccga cattgcaaat
      721 gaaataaata aaccagcagc tgttcgtgct gtaggtgcgg ctattggggc taatccggta
      781 ttaattactg taccgtgcca tcgtgtaata gggaagaatg gctcattaac tggctatcgg
      841 ggcggattcg aaatgaagac actgctcctc gatctggaaa agcgagcttc atctgaaatg
      901 gatgttcctc attgaaagtg aatcatctat aatgggttgg attcttttag aggaaagtaa
      961 agaccagttt actgataaac ttgacaactt ttaaaattta gcatatctta tacgtaactt
     1021 aataatcgat gccgatgttt atttttcctt ttaaaatatg taggccttta gcattctttt
     1081 catatttaat tttaaatatt gataggatga aaaagcatcc taactaaaaa ggaagagaaa
     1141 cataagtcga tttatttgat aatcaggact atattaaagg aaatgaaaac atagcataaa
     1201 gtaaagacca ataataaggt agctcttcaa aaaacttcgc tgaagttagt tgaagtgaag
     1261 ccgacaattt tcaggattca atgatctaac ataatcattg aaattttgaa gttgtcggct
     1321 tttttgttgg aaaaaaatag agataaataa aaattgaaat aaataataga caaatatgat
     1381 ctgattgaaa ggtcttttga ccaataatga gttttaaaaa agggagaatt tagaatgtta
     1441 gtttcgctga gtttgtcatc attattaaca ttatttttta ttatgcttat ggcttctggg
     1501 ataagtggac tattgttttt acatccgcga gtacccttga gttttgttcg cattcatatt
     1561 gggatcttgg ctttaccact tttggtttcc ttactgattc ttgccaatag tggtgtgagc
     1621 ggaaatgttg gcccttggca cttagattcc ttagcttgtt taatgacttt ctttgttctt
     1681 gcaattggat tcatcattca gcgtttttct gtacgttact taatggggga tcgatcttat
     1741 cgaaaatatt ttacgctttt tactttcaca acaggagctg cttcaatgac atggttaagt
     1801 ggtgatctcc gcttgatggt tctattttgg ggagcgactc ttgttggatt aaccttactt
     1861 attaggttaa acagtgcttg gcaagtggct agtgaagcag ccaaaatttc tggccggtta
     1921 tttttgttaa gttggttttc tttgtttttt gcgatgatgt ggctttttca tgccacaggt
     1981 caatggcagt tatcattggt tgtaacaaat gaaagtttag ctgggctggg agaatgggag
     2041 agaacaggga ttcagctatt gattgtactg gcggtgatca ttcctgcagc tcaatggccg
     2101 ttccaaagat ggttggttga gtctattgtt gctccaaccc ctgtttctgc aattatgcat
     2161 gcaggtttag taaatgctgg aggaataata ctaactcgat tttcacctct atttcatggt
     2221 ggtatcgctt cgattatctt acttctgctt gctggcattt ctgtaatgat tggaactgga
     2281 attagtttag tccaggttga ttataaacgc cagttagtag gctccacgat tggacaaatg
     2341 gggtttatgc tcattcagtg tgcattaggc gcctatatag cagccattat tcatcttatt
     2401 ttacatggtt tattcaaagc tacgttgttt ctacaagctg gttcagcagt agggcgtcat
     2461 gaagtatcgg ctcgcactaa tgaaagaaca tcctatttat gggtcatggc tggtcggatt
     2521 ttatccttag taataggcgt tgctttttgg ctcgctgctc ctggagaggg atatcaattc
     2581 attagtgcgc tgatcttagg gtggtcattg tccgtttctt ggactcagct tgtcgctttt
     2641 ggagagggcc gaattggccg aattgccggc ttaactgttt taggaggagc agccctcgta
     2701 tattttatta ttcatcacct tttctataag tggctgcata caaccatttt tcaaagtgtt
     2761 caacctccaa tgtcagctgt catgattgtc gtatgtctct tactctttgg cagtgcttta
     2821 ggtacgtggg ttgctcgtca tcgttcttcc gtttttttcg cggtactcta tctttggtta
     2881 gtccgattag gtgaagcaaa accaaagtca gtagagagtc acccagacta ccttaaacaa
     2941 tatatttcat aaggagctaa tctgagatgg gcattacatc cgtattaacg aaagataatg
     3001 taaaaaagat agatacagat attgatgttc aagaaaggga tcttaacgta ttcattacat
     3061 ctgccagccg agtgattgcg ccactttggc ctatttctac atttgctgca cgtaatccgt
     3121 ggatgggact tgaaaaccaa ccttttgatc aggttgcaag ttggttgaaa aacactcgcg
     3181 atgttgatat ataccctagt gcgtctatga tccgttcagc aaagaataaa ggtgagattg
     3241 atgaagattt tgtggaaatg gggctgcagc gttggcttga ttcacattcc tatcacatcc
     3301 cacgggacgt ggcagagcga ttttgtcatg ctgcattaaa gttagatccc ctgccttccg
     3361 accttttatc atcacatgag ctggagaaat tagtaggtga atgtagtgga ttggatcata
     3421 tcgagaatgt gtttatgcag ccactaagtt cgtatataga gaatcaagat ggtgaaaggc
     3481 tagtcaatat attagatcat catgtcatta aatggagtaa attatatctt gatgactctc
     3541 aagcaggctg gacaatgcct aatcgtgagg aaggtttcta tcgtgcttgg cagcatctca
     3601 ttcaatatga tccagcactt agcaaaaagc agcgagaaag ggtaaaaggt tggccgaaag
     3661 aggcacattt ggctttacag gaagccttat tcgcactaga aatcccagag tcagaaatcc
     3721 agacttatct tgaaggtcat ttactttcat tacctggatg ggcagggatg atgctttggc
     3781 gctcccagca atcgagccac gaacatgcac tcctaacaga atatttagcg gttcgaatat
     3841 ccatggagtg ggctcttata aagccatact tacctttgac taatgaacga tctaagaaaa
     3901 caatttcaat tgctcccctt atagcagctt ggattcattg gggtgggctt acattagaag
     3961 aatggtcaca gatgacggcc attgaacaaa acgaatattt atcatttgcc tacagctttg
     4021 atgagaaact tcgcaagaaa ctttggttag aggcttggga acaaacgtac actgatcgat
     4081 taagccagaa gatcatctcg aaacaacgtg aaaccggcca taaaaaatct gcattagctc
     4141 aattagcatt ctgcatcgat gtacgatcag aaccttttcg tcgtcaacta gaaaaagaag
     4201 gcccgtttga aacgattggt attgctggtt tcttcggggt gccgattgca acttgtgaac
     4261 ttggcagtaa acacagtcat gcttccttgc cgatcataca aaaaccgcaa aataaaataa
     4321 aagagttcgc aggtgaggat gtattcaaaa aatacaatca acggaagcaa gcaattcatt
     4381 ctttaagcca tacctttaaa acgatgaagc agaatgcgct ttcgagctta ctactgcctg
     4441 agctaagcgg accttggctt actctccaaa tggcagcacg tagctttgtg ccaagaaaag
     4501 cgggtcgttt cattcgtaat ctccgtgagg cttggctgcg caaacctgat acaaaactct
     4561 cgcttcatca tgatgctaca gaggcggaaa tacctgtggg ttttactgat gaagaaaaag
     4621 tgaactatgc tcgccaagca ttaaaaatga tggggttaac agagaatatc gcaccattgg
     4681 ttgtgatatg cgggcacggc agtcaaagta ccaataatcc ttattccgca gcacttgact
     4741 gtggcgcctg cggtggagcg gccggtggat tcaatgcaag agttttagct gctttatgta
     4801 atctatcaga ggtacgagaa gctcttttaa ctgaaggaat taaaatccct gaggatacgg
     4861 tttttgcggc agctgaacat aatacaacgg tggatgaatt acattggctt tatgtaccag
     4921 agctttccga agctgcacaa gaagcatttg aacaaattga agctgttatg ccgaaagtga
     4981 gacatcatgt aaacgcagaa cgtctagccc aattaccgaa tttccaatcg aagctaaaaa
     5041 atccgaaggc tgaggcaaac cgatttgcgg aagattggag tgagatacgt ccggaatggg
     5101 gactggctcg taatgccgct tttattatcg gtaaacgtga actaactcag gattgtgatt
     5161 tggaaggcag agcctttctc cataattatg attggaagca ggatgaaagc ggtgaactcc
     5221 tagcaaatat tattgcagga cctggaactg tagcccaatg gattaattta caatattacg
     5281 catcaacggt agcacctcat tattatggca gcggaaataa agcaactcaa accgttactt
     5341 caggtctcgg cgttatgcag gggaatgcaa gcgacttgtt agccggactg ccttggcaat
     5401 ccgtcatgga atcagatcac gaggcctatc attctcctct tcgtttattg atactcatcc
     5461 aagcacctag agaatatgta gaacggttat taaatcatga ctcagcattt ctgcaaaaag
     5521 ttcaaaatgg atgggtccga ctggctaata ttgatccaga aggatgttgg gaaagctggt
     5581 aatgatgaat gtaagcattt atcaaatgga tttgttattc aaaataaaaa tgataaacat
     5641 agggaagagg tgtgctgtat gaatgtaatc caaaataaaa aagtattgtt tttgacggat
     5701 attgaaaacg gtttggagcc tattttacaa gaagcgacta acacttctgc agagaatatg
     5761 ttgactatac aaagctatgg tgccggtatt tcacatcctt atggagaaat catgaggtct
     5821 gttatttttg cgatttacca ggaagatgtt gaggagattt ttgtagtagg aacaaaagac
     5881 aagaagactt ccgcaggtaa tggactaact caacttgaaa caatgaaaga taaaatacaa
     5941 acattggatt atctctttca aaattgcaag cctgaatttt taggtggtac ggtcgatgaa
     6001 tggctaaatg aaaatagcag tgacaccatt gaaaaaagtg ttgatatgat tcgacatcat
     6061 cccctagtgc cgtcatatgt taaagttaga ggtttattcg ttcatcataa ggatggaaaa
     6121 ccctcaatcg tggaggttcc tgatgttaaa acaggtcaag ccttacctga tcattgcttg
     6181 tcatgatgaa atacaggtcc aacttctaaa cgcacctata tatggagaaa gcagttctaa
     6241 ggagattgta tgagcgctaa tttaactgat tttgtcacga aaacaataga ggacatgaac
     6301 tcgtttgatc gtgaaaatat ggaatgtatg aaaaaactaa ttagaaaagc aattgatttt
     6361 tatcatctaa agtcttatga agaagttgag gaaacccatt caggaaatgt tcgatttttg
     6421 catgtccact ctatgatgga agaaaatatg ttatccaaaa tgatagtggt cacaagaaac
     6481 ggtaaaactg atttggatat tgaaggtgta tatgaaggat atgttgtaag agaatattaa
     6541 tgagacgaaa tcacaaatag aatatgccaa tttttttgct caggagatgt attagatatg
     6601 aaaaagtcga agggttctat tgaatcagag atcagtaagt ccattactaa atgggagaag
     6661 gattatcttg ggcgggggtc tgtatctgtt aagactgata tactgcggga catgatcatc
     6721 gtcaatttaa aagggatttt aacaccggcc gaatatgtag tttgtggatc aaaagagggt
     6781 atgttatcta tcaaacaaac tcgttcggag ttagttgaat caggtataga aggccttaag
     6841 gatattatct taaaaataac cggagaaaaa gtgaaaagtt ttcatactga tttaagctcc
     6901 cggacaggtg aacgagtgat ggtatttaaa ttatgtaatg atctagagaa aaatttggaa
     6961 aagatcttat aatctaaaga aaataaatgt taagacggta tggaatttgt tgtgaattga
     7021 acataaagaa ctgccgattc ttttgtttta caattatggt atcattgata acttttattc
     7081 atatcctaag cggacataaa gagatgtcaa ttcatagtac actgacttgt tattcctgtc
     7141 gaaagatcta acatccgctg ttgttatgag cggatgtttt tttacatcta ttttaaatac
     7201 atgaatttga tgctggtgat tagtcacttg aacaatatta aattcatttt aattgaaaac
     7261 atccttgtca ccttccaggt tcacccaagt gttttgtgaa atgattatga gaccaatttc
     7321 gtaaagcttg atgataaatt taagcggtga acaaaattga tatgctgtct tcagtttcat
     7381 ttcacggaat tagtcagaga taaaccttta attaaatata tccaaaaaac ggattgacat
     7441 atcgaaatat aacgatataa taatcgatat ggaaccaatt gaagtattca aagccttatc
     7501 aaatgaatca aggctgcaaa ttttacaatg gctgaaggag cccgatcgtc attttgcacc
     7561 ccatgaaggg attgatatga acacaatcgg ggtatgtgtc agtcaaataa cagacaaatt
     7621 gaaaatgacg caatcgacag cttctcaata tcttaccatc cttttaagag ccggcctaat
     7681 taaggcggag cgaatcggaa agtacacgta ttacaaaaga gatgaagaag ccattgggaa
     7741 acttgctgac tttcttaaaa cagagatata aaaataaaca tcaaaagatg tttattttta
     7801 caccatacat atcgacatat tacgatgtgt ttatttttta taataacata tcgataattc
     7861 gtgatatgtt tattaataat taaggagtga atgttttatg tctaacactt ggaaaattta
     7921 tattttagcc attgtcagct ttttagttgg aacctcagag tacatcattt ccggaatttt
     7981 ggatcaaatt gctcatactc tcgggatcac tttagctgcc gcgggccagt ttattaccat
     8041 tttttcactt gtatatgctc tttctacacc cgtacttatg gcgttgacag caagtatgga
     8101 tagacgcaaa ttgatgatgt atgccctagg tttgtttgtg ttcggtaatg tcctggcttt
     8161 tgtattgcct ggttatggat ggtttattgc agcgcggatc attatggcga tgggagcagg
     8221 tgtggtggtt gtcaccgcat taacgattgc cgctaagatt gcatcggaag ggaagcaggg
     8281 aagtgccatc gctacggtcg tgatgggatt taccgcttct ttaatcattg gtgttccgct
     8341 tggaagaatg ataccagtag cattaggctg gaagtctgta tttggagcca ttgctttgtt
     8401 gggattgatc gcaatggtcg ttattttctt tactcttccg catactgaag gggataagcc
     8461 tgtgcctttg cttcaacagc ttgctctttt caaaaaacgg aaagtggcta tgggattatc
     8521 aatcactttc ttctggctcg ggggatattc tgttgcttac acttatttgt caccgtatct
     8581 cttgaacatc tcaggtataa acggcaactt gcttagcggt gttttgctta tatttggaat
     8641 tgccagtttg gttggatcaa agtttggggg atatagcacc gataaatggg gagtgccctt
     8701 tacactcgtt ggcgggatga cgttgcatat cgtcacactg attcttctgt cacttgtcac
     8761 tcattcctat atcggagtgt tggtgattct catattatgg tcgtttgccg catggtccac
     8821 cggcccgaca cagcaatttc acctggctac aatagaaccg gaaatgtcag gtgttttgct
     8881 tagcatgaat cagtcaatga tgcaattcgc catggcggtc ggcgcaggta taggaggggt
     8941 ttttgtggaa aacgtatcat tggcctcgat tacctgggtt ggtgcgttag gggttatgat
     9001 tgccattatt gcatcattgc tgattttcaa ttcgcaaccg aaacaagcgc taaaagatat
     9061 caatcaataa tttcgaaagt tctaacatcc gctcgttata caagcgggtg ttttttataa
     9121 gcattcaaag tcagtccatg catgagcctt ccaagggccg acatcgttct gtatgtgtcg
     9181 aaggcgcact gaagctgaaa gggatttctt aaggctttgc cgctgaagta cggtactacg
     9241 gtacgattgc cttgatcgaa cactggaaac acaagagaac gtaaacctga acatccgcgt
     9301 aaacgtcaag gaagttgcca cttggggagt aaacacttgc atcatctcgc tgaaaggcct
     9361 agacaatgcg gatgacatat tcgtattgcc ggaagtaaac acagcgcttg ctctgtttcc
     9421 gttggtttct gttgtcggtt gcagctgatt gcttactaat gctgccctgc atctcggttg
     9481 tgatgtcgat aagcagcgta accttgtgaa gagtgttact gtggagtaag atgtttaacc
     9541 cctttggata ttttagccga aggggttttt agtatagata tttgatttaa attacaggag
     9601 acttcattca tttaactaaa gtcattgctt tcttaatcac taaagtttat ttgaaaataa
     9661 tctcttgatt taatttcctc gaagagattg tttgtcaatc tattaggcat cagaattttt
     9721 ataacagaat ggatcgtctt tttgacgttt tgtttataga acaagaaaat attcaaaaca
     9781 taagtggaaa attaggggtg agctcctgtt tttctcgaga ggatagcttg tcagcttttc
     9841 tatttttaaa gggttaaaat attgtattta tactaattaa tgtaattttt aggataatat
     9901 acaaaatccc ccttacttcg acaattgcaa tctggtatta tcgtatcgca tgggagctat
     9961 gtcaatagac tctatgcaaa aattaagagg aggtttactt atgaaaagaa accaaaaaga
    10021 atgggaatct gttagtaaaa aaggacttat gaagccggga ggtacttcga ttgtgaaggc
    10081 tgctggctgc atgggctgtt gggcctcgaa gagtattgct atgacacgtg tttgtgcact
    10141 tccgcatcct gctatgagag ctatttaaca tttgagaata gggagttgag cgtatttgct
    10201 tatactcctt attttctctt aagggggatt ttatatgtca tatgatcgtg ttaaagattt
    10261 tgatttgcca gagttagcgg ttcatttaca gcctcatggt gctgtaatga ttgatagaaa
    10321 aagtatgttt tatttcagac tcagtggacg tggagcacag ttggcgtttc tgttatcaaa
    10381 aaacaaaaat cttcataaaa cggcacgtat ttgggagatt atgaaaaaag aagagatgag
    10441 tgctgaccaa ttaaaagaag agcttagtgc ccatccattt acggaggctt ggacggaagg
    10501 actgttagat cagcctttac acgtttcggg ttcgctagat tcatatttac ctattagttg
    10561 taccttgcag ttgacaaatg cttgtaattt aagctgttcg ttttgctatg ccagctcagg
    10621 taaaccatat cctgaggaac tatctagtga acaatggata ttggttatgc aaaagttagc
    10681 agcccatgga gttgctgata ttacgctgac cgggggtgaa gcaaagctga tcaaagggtt
    10741 taaagaatta gtcgttgttg caagttcgtt gtttaccaat gtgaatgtat ttagtaatgg
    10801 attgaactgg cgagatgaag aagttgaatt acttagtcac ttaggcaatg tttctgtaca
    10861 gattagtatt gatggtatgg ataatacaca tgaccaatta agaggcagaa aaggcggctt
    10921 taaagaaagt atgaatacca ttaaaaaatt atcagaagca aacattccag tgattgtcgc
    10981 tatgaccatt aatgagtcca atgctgatga agtatcagat gtggtggagc aatgtgccaa
    11041 tgcgggtgct tttatctttc gtgcaggaaa aacgttatct gttggacgtg cgacagaagg
    11101 ctttaaggct ttggatattg attttgaaga aatggttcaa atacagctta gggaagcacg
    11161 tcataaatgg ggagatcgcc tgaacataat tgattgggag cacgaagaga gttcgttcac
    11221 aacagatttt tgtacaccag gatatcttgc ttggtatata agagcagatg gatacgtaac
    11281 tccttgccaa ttagaagatt tgccgctagg gcatatttta gaagatagca tggctgacat
    11341 tggttcacct gctcgtttgc ttcagttaaa atgtgaagct aaaaattgca aatgtatagg
    11401 gaaaattgag ctatctgaac cggacttgcc ttttcaaaaa gaagtcaagg cagggattca
    11461 ggaatgaata gtctatcatt ggtgttctgg agtattttag cagttgttgg attactgtta
    11521 tttattaaat tcaaaccccc aacaattgct tcactactct taagcaaaga tgaggcaaaa
    11581 gaaataagca ttcaatttat aaaagagttt gttgggatag atgtagagaa ctgggatttt
    11641 tattcggtat attggtatga ccacgataca gtaaataaac ttcatcactt aggcatactt
    11701 aagaaaaata gaaaggtttt atatgatgtt gggttggtcg aatcatggag agtccgtttc
    11761 gttcaccaga atcaatcatt tgtagttggt gtcaatgcca atcgagaaat cacttttttt
    11821 tatgcggatg ttccgaaaaa aaccctttcg gggaagtttg aacaagtttc tccagagaca
    11881 ctcaagcaga ggttaatggc ttcacctgat ggactttggt ctagagcaaa tatgactggt
    11941 actggtaaaa aagaggagga ttttcgcgag gtcagtactt attggtacat agcggaagcg
    12001 ggagatattc ggctcaaggt gactgttgaa ttacagggcg gccgaatttc ttatattggt
    12061 actgaacaag aaatactaac agatcaaatg agtaaagtca ttcgagatga acaagtggaa
    12121 tcgacattcg gagtatctgg tatgctgggt tcagctttag cgatgatcct tgcgattctc
    12181 atccttgtat ttatggatgt gcaaacaagc ataatcttca gtcttgttct gggtttgttg
    12241 attataatat tccagtcatt gacgctgaaa gaagatattc aattaacaat tgtaaatgct
    12301 tatgatgcaa gaatgagtgt caaaacggtc agtttattag gtattttgtc tacacttctt
    12361 acaggattat taacaggatt tgtagtattt atatgttcat tggcaggaaa tgcgcttgct
    12421 ggtgattttg gatggaaaac gtttgaacaa ccaatagttc agattttcta tggaatagga
    12481 gcagggctca ttagtttagg agtgacttct ctgttgttta acttattgga gaaaaagcat
    12541 tatttacgaa tttcacctga gctttctaac cgaactgtct ttctatcagg ttttaccttt
    12601 aggcaaggat tgaatatgag catacaaagt tcaattggag aagaggtcat ctatcggcta
    12661 ttaatgattc cagtcatttg gtggatgagt ggaaatatcc tcatctccat tattgtatct
    12721 tcctttttat gggcggtgat gcaccaagta actggatatg acccaaggtg gatacgttgg
    12781 ctgcatctat ttatattcgg ttgctttctg ggagttctct tcatcaaatt tggttttatt
    12841 tgtgtattag tagctcattt cattcataat ttagtaatcg tctgtatgcc gctgtggcag
    12901 ttcaagcttc agaaacatat gcatcatgat cagccaaagc atacttcact ctaatgatta
    12961 ggagaagatt tgatgcaatt gatgcaagta caaaatttaa gcaaatgcta tcgaaatggt
    13021 gatggggttg aacatttgtc tttctcaatt caacgaggag aaatcgtggc gctattgggg
    13081 ccaaatggag ctggaaaaac aacgacaatt cgatgtttga caggtctcta taagccggat
    13141 aaaggagata tcctcattga gggttctcct ccaggacata taaatgttca aaaaaaagtc
    13201 gcgcttattc ctgatcagcc atatctgtat cccgctttaa ccgctgctga acatattcag
    13261 tttagggcaa gaggatatca tccaggtaaa aaagatgtaa aagaaagggt ttatcatgca
    13321 ttgaaggaag tgcacttgga ggagaaagca aaccaattgt gtggtcagct gtcaagaggc
    13381 caaaagcagc gggttgtcct ggcgggggcg attgttcaag acgctttgct gtatatatta
    13441 gacgaaccga ctgtgggcct tgatatccca tcaaaacagt ggctctctaa ctggttaaaa
    13501 actaaaaccg atcaagagtg ttcagcattt gtatcaactc atagtctaga gtttgtttta
    13561 gagacagcag acagggtgat attaattaga gacggcaaac tcatgcagga tttgtatgtt
    13621 cctcaattcg aagaagaaca agcggaatgg agaaaagaag tgatacgtct tctgggggaa
    13681 tggtcagatg aataatatca tttctttttt atggcttcag tcaaaaaggc gttttgtcag
    13741 tcaaggtcag gaaaaaaaaa tgcctttttt gatcatgctc ctttttgttg gggccatcgg
    13801 atttcaagta agttttgttt ctagatctac gacatgggat atgagtattg ctggttgggt
    13861 acttacaggt gtttttatcc tttatacggc atttggactt ttttcaaatc gattaccaag
    13921 tcaaatggca gatattatat ggctttatgg cactgccaca tctttttcaa aagttgtgta
    13981 tagtgtttta tttttcagcg tcacttggaa ggcgttgctt tggatcatct cagccatatt
    14041 cggtgatgta ttaattgtgc ttctgtctgg tgagcatatc aatttattag gccgatccat
    14101 aatttttata gggctctttt ttatcgctga agtgtggttg atgtcggtct cctgtgccag
    14161 aacagtgaag aaaatgaaaa gggtatacgt ttcagtcttt cttctaatgt taggcattta
    14221 ctccatatgt ctttatcaat tcttctttct ccaacattca tctgggatat gggagagcat
    14281 tgcccgtttt attagtggcg ttggattagt gtttgataca ttgtcaccgt tgtatgtggt
    14341 tgtatttatt gggatcatca cagtctcttt tatgacaatt gcttttacga gccgtcaggt
    14401 agaaatgagg gaatcgttgg tgaaagaagc tgaattctgg gaggaatttc aagaacgtca
    14461 atttggttca ggtcaaatta tacagaaacc aaaaacgact tggtggggct tgcaaggtct
    14521 aaatggcatt tggtcttttc tgtggttgga actgttgctt tttaaaaaat atttattttt
    14581 tcatagcatt catacggtca tgctcagtgg cgtcttttat gtcgtcattt tcatgtatcc
    14641 agaatggttt tatcttcttt tctttcttat cgtctcggca gtcatgttaa gttcctatta
    14701 ttcaggaatt gtcagacatt ctcaatcagg cacccttcat ttattccccg gtgccctttg
    14761 gaaaaaaatc attattctag agctgacgaa tacagtctgg ttgtatattc tctactgtgt
    14821 ctctattact tttatggcag ttgggaattt agtttattgg tatatatatg gcttagggat
    14881 atatatatgg ttcatgacaa taaggctttt tgcttttacc catacaaacc gaaacgatat
    14941 taagctttca ttgcctcaat attacaagtc attttttatg gcattaggcc tgagcggcat
    15001 ttgtttgtat gtcattcatt tattgactgc tgactggtat acattagtgg tggtcgtctg
    15061 tatagggagc ctaagttggt gcctgtttta tcgtttcaga tagtggttat gtagagttat
    15121 tgttttaaaa cgaggagagg ggctctttta tgaattcaaa tggtgataaa ttgtcgttat
    15181 ctgttcagaa tttagcgaat acaaatgaga tcacaattgt tcaagcgata ggtgagctaa
    15241 agaaatcggg aaaagatgca ataccagttt tggttgaggc cttaaaagag gaaggctctt
    15301 tgtgtaatat tgctgcagct gttttaggtg agtttgggga agacgcgagt gaagcagcgg
    15361 aggagctatc atgtttatta aaaagtcatg ccgaagatac aagaatggca gcggcgattt
    15421 cattaatgag aatcgggaag cccagtctgc cctttgtcat caaaatcgct caagaaagtg
    15481 aagggcaatc gtgcttttgg gcatcttggt gtattgcatg gattgatccg tcttgcattg
    15541 aacctaagat gtataaatgt ctaaaatacg agcatgaaca tccttcagga atagttgctc
    15601 cgtttgcggc tgaagaggca ttaggaaagc tgattgcttt tcagctgaaa gataaggagg
    15661 actgaaagga tgaaagatga acaaatgttg actgaatggc caagtcattt accatggttg
    15721 aatcaatcac agaatgattt tacatttcca agtgacacat atcttcttct ttatttttgg
    15781 tcaatgagct gtccaaactg tcaccaatta acagacaaag tccttcaaga tataaaggat
    15841 atgaatgtga aagtaatcgg agtacatgtc ccttatatag aagaagagaa atctatggag
    15901 gttgtcttga cgtatgctct tgatagggga ctagctattc cgattgtatt agaccaaaac
    15961 tatgagatcg tcacaacttg tcacgtacaa ggcatcccca gcttttgtct attaagtcaa
    16021 tacggtcaga tcattactaa aacgatggga gatgttggtt gggataagat gttaaaaaag
    16081 attgcaggct tgtgaaattt tccgtcttgt atgtgcgaca aacggttgaa tattatgatg
    16141 aaacggtcct tcctataagc aggaaggttt ttttatgaaa tattttttta ttagtaggta
    16201 aattcatcaa atgttctgct atgctccaaa tgtacacctt tccgtaaggg caaagttaaa
    16261 tgtgaaaata aaactgttcc aaagttaatc agaaatttat tttcatattg tatcttttca
    16321 gtatcaagtg aaaggagcat catatgaaaa cattatggaa agtcctcaaa attgtttttg
    16381 tcagcttggc tgctttggtt ttgcttgtat gcgtctcggt atttatttat caccatttcc
    16441 agctaaatag ggaggcggca ctccttaaag aaaaaggcac attagtcgaa gttgatggta
    16501 aaaagatgaa tgtgtatcaa gagggaagcg ggaaggatac gtttgtgttt atgtccggtt
    16561 cggggattgc tgcgcctgct tatgaaatga aggggctgta cagcaagttt tcaaaagaaa
    16621 ataagattgc tgttgtagat cgggcaggtt atggatacag tgaagtgtct cacgatgaca
    16681 gagatattga tacggtattg gaacagacga ggaaagcgct tatgaaaagc ggaaataagc
    16741 ctccttatat tttaatgcct cattcgatat ccgggattga agcgatgtat tgggcacaga
    16801 aatatcctaa ggaaatcaag gccattattg cgatggatat tggattgccc cagcagtacg
    16861 tcacgtataa attgagcgga gttgaccgat tgaaagtgag agggttccac ctgttaacct
    16921 cgattggttt tcatcggttt ataccttccg ctgtatataa tcctgaggtg attcggcagt
    16981 cgtttttaac tgatgaagaa aaagaaatct ataaagccat taactttaag caatttttta
    17041 atgcagatat ggagcatgag cttttgcagt cttaccaaaa cggcagcaaa tctgtgaatc
    17101 tgccggcgcc aaaggaaact cccgtcttga ttttagatgc ggtctctgac caaaatagac
    17161 attcaaagta tgctatacaa aaccgaaaag actatgaagc gtttgcggct caattcaata
    17221 ctgccgatat aaaggaactg agggaaacac acagtattta tttatatcag cctgatcaaa
    17281 tatataaact gtccatggag tttatgagaa aggttcgcta ggatgaaggg ttatcatatt
    17341 ttaatcgttg aagacgatgt gatgattggt gatttgctgc aaaagatttt gcagcgtgag
    17401 ggatatcgtg tgatatggaa aacagatggg gcggatgtgc tttcggtgat tcagaaggtg
    17461 gatttggtca ttatggatgt gatgctgccg ggtgaagacg ggtatcaaat gtctgcaaaa
    17521 atcaaagagc tggggctggg cattccggtt atttttctct cagcccgcaa tgacatggac
    17581 agcaagcttc aaggtttgca gatcggcgag gattatatgg taaagccctt tgatccgaga
    17641 gagctgctat taagaatgcg gaatatgctt gagcatcatt atggcacctt tacgcaaatc
    17701 aaacatttgt atattgatgc agtaacgaaa aaagtgttca atgaaagcct gcatgatgag
    17761 gtattattta ctgcgattga gcggaaaatt ttcttttatt tatatgaaaa tagagacagt
    17821 atcctgacaa aggaacattt ctttgaatat ctatggcagc tcgaagatag aaacccgaat
    17881 attgtcaatg tgcatattaa aaaaatcaga gctaaaatca atgatcaagc gggtgagatg
    17941 attgaaaata tatatggaga agggtatcgg ctgaataccg ttgtgaagaa atgaagctca
    18001 agacaaaata tcagttgtta ttgtttacgg ctgtcattag tgttccgatg ctgttgctgg
    18061 cggtcagtgt tttgatgtct gttatttatg acagcatgtt taaaccgatg aatcatggta
    18121 tgccctttca caggtcgttt gcgtacccgg caatgatcgt tgtatttttg atatcgctct
    18181 tattgttagc ttttttattt tcaaagtcga ttcattctct gttgcataaa atcaatctat
    18241 taaatcaaac cattcggcat ttggcgagtg atcaaagggt gcccgataaa attgaagtga
    18301 agcgtgctga tgaaatcggg gaactgatca agtcggtcaa tttgttaatt gaacggacga
    18361 catatcgtga actggagctg agacagcaag aggaaatcaa aaaggagctt ttgcaaaaac
    18421 tgcggcatga cattaataca cctttaacgg ctctcaggct gcagttattt tatttggaag
    18481 accaatgtca tggtcaggct gtattcgaat cattgtatca gcaaatcgaa tatatctcgg
    18541 aattaaccaa tgaattcaat ctatattccg ctgagacgct ggaaagctct tatattgtaa
    18601 atgaagaagt gcgtctaaac gagctattag aaacagcggt gaaaaagtgg gattatttat
    18661 acagtatgag tgggattgag ctgcactata aggcggcaga tcaagatgtg atatggatga
    18721 gcaacgcgtt atggatgcaa aggctgtttg ataatatttt tcaaaatacg ttaaagcatt
    18781 caaaagctga aaagatggaa gtcacgattg aacatgacaa tgtttttatt cgtgatgacg
    18841 gtattggatt tgatcggaat gagagcagtg agggacttgg attaaagatt attgaggata
    18901 catgcaggct gcttgcgatt acttatgagc tgcatacaaa tgatagcgga acggggttct
    18961 tgttttcaaa agagtgaccc cgctgatgtt tttctttctc ctataaaatt tatataatag
    19021 ggagaaagaa atggggtgaa cagcatatgt ttaaaaaaat catcaaaacg attaagtacc
    19081 tctcaagcag ttctagtgac cgatatcgca gacaccggca ttacagcagc agccggcgca
    19141 gacattatcg cagctacagc agctcgggca aaagaagaca ctacgaccgt tatggcggca
    19201 gtcatcgtta caaacgccgg agctacagca gcagttaatc caaaaaagtt cttgttccgc
    19261 ttttgggaca agggtttttt tatgtgaccg attgaatggc ccggtttaga tcctcgcgaa
    19321 tggaagcggt gtgctgatac tcttcctcaa tgcccaataa tcttttcagc agcaaggtta
    19381 cttcctttgt cagtgttaat tcctccagcc aagtgccgtt tttcttcttt tttcctttat
    19441 attgagagta cagcaggaat aacagcgttt ctccgagatc gaagaagtca tcctgttttc
    19501 gtacctttat ttcctccatt tcttcaggag tcaattgttt ggcaaggccg aaatcgatga
    19561 ggcagagcct gccatcattg atgatgatat taggcgttct gatgtcgctg tggaagataa
    19621 ggcgatcatg caggtattct ataatctcaa gcagctgcga aatcagttgt aatgccataa
    19681 gctctgtgaa cggctgtttt cgaaaaaata ataattcttc tatattctct ccctcaatga
    19741 actgcatgac ataataagcc tgtccgtcta tgatgaactc atctatgaag cccggaattt
    19801 gcgggtggtg aatgctattg agcagtttta tttcctgttg gaatcggact ttctcttttt
    19861 cctttttcgc ttttgtcggc cgaagctgtt ttaagacata aggtgtttga gttaggatat
    19921 cggtgcacaa ataaaccaaa ccgtagcctc ccataccgag gcactcttcg attttgtatt
    19981 gatgatttaa gataacgccg ttctttagag ggcggtcaaa tagcagtttt tttagaagtt
    20041 ttaatgccat gtctgcactt cccttggttg tactgactat agtttacctt ctagacggag
    20101 aataaaaaag agccggatca ccggctcggt ataagttaaa actgctttgt cacgtcgtat
    20161 tcataatcta tttttgcttt tacgttgctc atcgtcgatc tggcagtcgc taatgtatta
    20221 tatttaaaac tccatacctt tgccacactg agttgatctg acaaagagat atcataagac
    20281 cctgaagtcg agctgtttac aagagcacgg cgccattcgt tgttttcgct cgtcatgatc
    20341 aggtggcgtg tatttccctg gcttggtgtt tgagtggcgg ttgtctgaac tctggttaca
    20401 atggcatcac gcggtatccc agattggttt gttaaatcaa ccttgatcac gctggagtca
    20461 gaacctgagg ggctaaggct tgtatttcct ttattttcag caatgccgct gaattggaat
    20521 gttccgctgc ctgatttgat tcggtcttca attgaaagtg taaaatacat gtttccggta
    20581 taggtgcctc gtgacacttt cacataaaag gtatccgtcg tgttttgggc gtctgcattt
    20641 gcataaataa aagaagaaaa cgtattaggg ttaatgactt ctgtcccttg agaaacaggt
    20701 attctattct tatcataaat ttcaattttc atccctgtat acgcgctctg gtatgtactc
    20761 ctcacgtata ctttttctcc cttattagcc gtaaaagtga aataggcttc atcttgacca
    20821 gcttccagta ttgttgtatc gatattttta tatttccaat aaccgatcgg cattgcggta
    20881 tcaaatgaat tgtttcctgt gatagcagtg actccgacag ctgatgccga atacgtaaag
    20941 gtgaataaga cagacagcat aacagcgaat ggaataagcc attttttcac catgcaaaca
    21001 acctcctttt atttccatca tacataataa cgatttaggt gtaaataaat gttttttgag
    21061 gttaatatat acattatctt tgccgataaa aaagaataag agagaatact cgggagggaa
    21121 ttcaatgcgt ctgaatcggc aatttatccg cactcagctg atggcacaga acatattgag
    21181 caagaatgcg cctgccaaac gggagaatgc gactgaaaat ccagcggcag ttctggaaaa
    21241 ggcatacagc aggcttaagt cacaatcttc aactggggga atcaatcagt tcaattattc
    21301 taaaaccagc gtgtcgggaa acagcgggac gttcagcaaa gtgtatcaat cagcgaatga
    21361 tcgaacagtg acagacacag gggaagaaac agtgattcaa tcccaaaacc cctatgaatc
    21421 tgagagtgat atcagaatca aaatactaga tgaaaaatac agcaggatga atgcgattaa
    21481 caaaacaaag tctgatccat taggctatat taaggataag taccaaaatt caaagtctcc
    21541 ttatttcaga agtgatctgt cagctgcaga aagacaggcc gcttacgata atgaaacaga
    21601 atggctattc aaaggcaagg cccaaaacta taaccttcag gatgctgtgt ttcggaatgt
    21661 cacatttcat gtggaagtgg aagctgagaa tgaaaaggtg tatcagcggg gacaggttaa
    21721 ccagcagctg caagtgctgt tgaatcgaaa caacatttat attccagagg ggacagagct
    21781 gacgtttaca atcacaccga ttgactatca ggtgcgggtg agcgggacag acgaccagga
    21841 tctgatcaag caaattgagc aagtgctgca atctggagac aacagcaaag aactattttt
    21901 gcacatcatg aaaagccaaa gcagtgattc aacacaattt tccgaagagg cctatcaaaa
    21961 gtatcaggca gctcgtgaga tgtacgaagt cacaggctat caattgaagg atttagaagt
    22021 gattgatggg cggtatatca cgcctgatgg acgtgactta ttagatgtat ataaggaaga
    22081 gcttgaaaaa gatccagtgc agaaacaaac ggcttcttat gctatatctt actatcgttc
    22141 agagctcagt aaaatcgcgg aagccgggta taatgccatt ccggatttca tcctatcaat
    22201 tgattacagc aatggatctc tgagagatgt gggacaaagc aagagctatg ggaccggaga
    22261 taccgggtgg cttgaagcat taaagcgtca aacgggtgtg aattattaag taagctgttc
    22321 atgtagaaca gcttattttt tatgagaatc taaggggcat attaatttca atattcaaac
    22381 aattttatta tttttatata aaagatttta aaagaagtga acgattcaaa actctgaaca
    22441 aaggtgttta cctgaaaaaa acaattgtat tttccagaga aatttattat gatgaaataa
    22501 gtaatttagg agattatata acaattttaa gtttgaattt tctgattgtt atcactgatt
    22561 catgtgaagg caagcaggtc tgctgttttc tcatttatga gtattttgtt aggaggagga
    22621 agaggagtgg caaataaaga attaaagagg ggcctgggcg cgcgccatat tcagatgatc
    22681 gccttgggcg gtacgatcgg tgttggcttg tttatgggtt ctgccagcac gatttcatgg
    22741 actggcccat ctgtccttct ggcttatgca atatgcggaa tttttatctt ttttattatg
    22801 cgtgcgatgg gtgaaatgct gtatgtcgag ccgagcacag gttcttttgc gacgttcggc
    22861 catcaatata ttcatccgat ggcaggttat ataacagcat ggagcaactg gttccagtgg
    22921 attatcgtcg gcatgtcaga aattatcgct gtcg
//
