GCF_022559645.1 - 14 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP044132.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS,transAT-PKS	197,837	275,566	Low	locillomycin/locillomycin B/locillomycin C	NRPS:Type I+PKS
Region 2	NRPS	354,681	420,088	High	surfactin	NRPS:Type I
Region 3	cyclic-lactone-autoinducer,lanthipeptide-class-ii	672,125	701,383	High	amyloliquecidin GF610	ribosomal:RiPP
Region 4	PKS-like	1,029,463	1,070,707
Region 5	terpene	1,153,507	1,174,247
Region 6	transAT-PKS	1,482,680	1,570,905	High	macrolactin H	PKS
Region 7	transAT-PKS,T3PKS,NRPS	1,796,934	1,907,039	High	bacillaene	NRPS:Type I+PKS:Type I
Region 8	NRPS,transAT-PKS,betalactone	2,104,023	2,241,841	High	fengycin	NRPS:Type I
Region 9	terpene	2,267,123	2,289,006
Region 10	T3PKS	2,357,078	2,398,178
Region 11	transAT-PKS	2,513,917	2,620,096	High	difficidin	PKS
Region 12	terpene-precursor	2,642,191	2,663,081
Region 13	terpene-precursor,NRP-metallophore,NRPS,RiPP-like	3,245,981	3,311,298	High	bacillibactin	NRPS:Type I
Region 14	other	3,842,622	3,884,040	High	bacilysin	other:other

NZ_CP044132.1 - Region 1 - NRPS,transAT-PKS

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Location: 197,837 - 275,566 nt. (total: 77,730 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

F5K02_RS01170: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

F5K02_RS01260: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

F5K02_RS01345: dehydrogenase

smcogs: SMCOG1181: dehydrogenase

Transferases: acylase acyltransferase methyltransferase

F5K02_RS01245: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

F5K02_RS01270: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

F5K02_RS20910: polyketide synthase associated protein papA3

smcogs: SMCOG1209: polyketide synthase associated protein papA3

Hydrolases: esterase hydrolase

F5K02_RS01195: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

F5K02_RS01230: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

F5K02_RS01250: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

F5K02_RS01255: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

F5K02_RS01265: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

F5K02_RS01300: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

F5K02_RS20905: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease

F5K02_RS01190: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

F5K02_RS01295: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.87	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.82	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.82	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.81	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001261.3	0.81	NRPS	AM-toxin	Alternaria alternata
BGC0001249.5	0.81	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001135.5	0.81	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.80	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000426.5	0.73	NRPS	sevadicin	Paenibacillus larvae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.72	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001261.3	0.72	NRPS	AM-toxin	Alternaria alternata
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001135.5	0.72	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.69	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000426.5	0.69	NRPS	sevadicin	Paenibacillus larvae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.86 out of 26.06

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 25.01 out of 30.22

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.63 out of 27.55

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.10 out of 21.84

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.42 out of 27.78

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.52 out of 28.19

Confidence: medium

Additional weak hits (4):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.39 out of 28.14

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.71 out of 20.47

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.30 out of 32.93

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 197836 - 275566:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val - D-Phe - Asp) + (D-Asn - Gly) + (ccmal) + (ccmal) + (mal - D-Glu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F5K02_RS20905: Val - Phe

Search NORINE for peptide: strict or relaxed

AMP-binding (248..645): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LETAFDASTFEGWLLVGGDINGYGPTEGTTFTCC
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1287..1678): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: LVFAFDASVWEMTLITAGSINAYGPTETTICSTM
Nearest Stachelhaus code(s):: Phe DAWTIAAICK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS20910: Asp - Asn - Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (264..665): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWVSFDLCYTSPKMILGGEINHYGPTESTVGCIA
Nearest Stachelhaus code(s):: Asp DLTKIGHVGK (65% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1303..1697): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGEYNEYGPTEATVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2805..3198): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FGITFDIFGLELQLMVGGEYNMYGPTETTIWSSV
Nearest Stachelhaus code(s):: Gly DILQMGMVWK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)

F5K02_RS01245: mal

PKS_AT (6..293): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 75.0%; 2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 111.1
inactive: 50.8
Methoxymalonyl-CoA: 39.3
Isobutyryl-CoA: 31.6
Methylmalonyl-CoA: 29.7
Propionyl-CoA: 12.0
CHC-CoA: 10.8
fatty_acid: 10.4
Benzoyl-CoA: 10.0
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

F5K02_RS01265: Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (1198..1599): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LALAFDASVKQSDGIIGGETNVYGPTECCVDAAS
Nearest Stachelhaus code(s):: Glu DAKDIGVVDK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
ClgR	Caseinolytic protease gene regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
MexT	Global virulence regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP044132.1 - Region 2 - NRPS

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Location: 354,681 - 420,088 nt. (total: 65,408 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase electron transfer oxidoreductase reductase

F5K02_RS01750: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

F5K02_RS01765: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

F5K02_RS01770: flavodoxin

smcogs: SMCOG1134: flavodoxin

F5K02_RS01775: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

F5K02_RS01790: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: PPTase aminotransferase

F5K02_RS01870: aminotransferase

smcogs: SMCOG1019: aminotransferase

F5K02_RS01885: aminotransferase

smcogs: SMCOG1019: aminotransferase

F5K02_RS01890: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase

F5K02_RS01865: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

F5K02_RS01785: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

F5K02_RS01835: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F5K02_RS01840: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

F5K02_RS01850: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F5K02_RS01860: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000433.5	0.90	NRPS	surfactin	Bacillus velezensis FZB42
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000433.5	0.90	NRPS	surfactin	Bacillus velezensis FZB42
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.80 out of 27.78

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.76 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

Additional weak hits (18):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.91 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 23.04 out of 30.12

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.79 out of 20.01

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.29 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.14 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.78 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.24 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.63 out of 36.54

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 354680 - 420088:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu - D-Leu) + (Val) + (Asp - D-Leu) + (Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F5K02_RS01835: Glu - Leu - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (465..867): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1511..1908): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
Nearest Stachelhaus code(s):: Leu DAFMMGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2550..2939): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASIWEPFLLVGGDINNYGPTENTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS01840: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (470..864): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS01850: Asp - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (429..831): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1474..1863): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS01860: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (469..867): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LHVSFDAFTFDAFALFGGEINCYGPTEGTVFATA
Nearest Stachelhaus code(s):: Leu DAFFLGCVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP044132.1 - Region 3 - cyclic-lactone-autoinducer,lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 672,125 - 701,383 nt. (total: 29,259 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

F5K02_RS03630: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

F5K02_RS03565: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

F5K02_RS03580: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002663.2	1.14	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000517.4	0.55	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.43	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000504.5	0.41	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.39	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000497.3	0.36	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0001311.5	0.36	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000552.3	0.33	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001391.3	0.33	ribosomal	thusin	Bacillus thuringiensis serovar rongseni

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002663.2	0.95	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000623.3	0.66	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000517.4	0.65	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000504.5	0.61	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.56	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.55	ribosomal	thuricin	Bacillus thuringiensis
BGC0000499.3	0.55	ribosomal	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000497.3	0.54	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000525.5	0.54	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0002110.3	0.54	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for F5K02_RS03565

F5K02_RS03495

Leader:

MENRSALFG

Core:

FFEDCWKNGTVLTVEMRKAVEKGRITKEEYDEITAKERGSAYPDQE

Core with dehydrations:

FFEDCysWKNGDhbVLDhbVEMRKAVEKGRIDhbKEEYDEIDhbAKERGDhaAYPDQE

antiSMASH-DB 4.0 matches for F5K02_RS03495

100.0%

NZ_CP044132.1:

Lanthipeptides: F5K02_RS03495_lanthipeptide

1

FFEDCWKNGTVLTVEMRKAVEKGRITKEEYDEITAKERGSAYPDQE

46

FFEDCWKNGTVLTVEMRKAVEKGRITKEEYDEITAKERGSAYPDQE

1

FFEDCWKNGTVLTVEMRKAVEKGRITKEEYDEITAKERGSAYPDQE

46

17.4%

NZ_JACEIQ010000001.1and 1 other:

NZ_JACEIQ010000001.1 Lanthipeptides: H1191_RS00055_lanthipeptide

Lanthipeptides: H1191_RS00055_lanthipeptide

15

EMRKAVEKGRITKEEYD

31

E+ +A +GRIT++EY+

17

ELLRAYCEGRITEDEYN

33

F5K02_RS03560

Leader:

MSIIETWKNPALRMNSQVVNPAGDLMEELSDDEMEMLAGG

Core:

CAWYDISCKLGNKGAWCTLTVECQSSCN

Core with dehydrations:

CysAWYDIDhaCysKLGNKGAWCysDhbLDhbVECysQDhaDhaCysN

antiSMASH-DB 4.0 matches for F5K02_RS03560

100.0%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWYDISCKLGNKGAWCTLTVECQSSCN

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

85.7%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWYD+SC+LGNKGAWCTLTVECQ++CN

1

CAWYDVSCRLGNKGAWCTLTVECQNNCN

28

75.0%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSC

27

C WY+ISC+LGNKG WCTLT ECQ SC

1

CEWYNISCQLGNKGQWCTLTKECQRSC

27

with 101 more sequence matches

Only the first 10 are displayed here.

71.9%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWY+ISC+LGNKGA+CTLTVEC SCN

5

CAWYNISCRLGNKGAYCTLTVECMPSCN

32

65.5%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

C W++ISC LGN G +CTLT ECQ SCN

1

CDWWNISCHLGNTGQFCTLTKECQPSCN

28

62.1%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

C W++ISC LGN G +CTLT ECQ +CN

1

CDWWNISCHLGNTGRFCTLTKECQPNCN

28

60.7%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

3

WYDISCKLGNKGAWCTLTVECQSSCN

28

W+++S LGNKG CTLT ECQS CN

1

WWNVSKNLGNKGRICTLTKECQSMCN

26

57.1%

NZ_FOBE01000018.1:

Lanthipeptides: BMW61_RS13085_lanthipeptide

2

AWY-DISCKLGNKGAWCTLTVECQSSCN

28

WY ++S LGN+G++CTLT ECQ+ CN

1

GWYSEMSAALGNRGSYCTLTKECQACCN

28

57.1%

NZ_KE384107.1:

Lanthipeptides: G586_RS23925_lanthipeptide

2

AWY-DISCKLGNKGAWCTLTVECQSSCN

28

WY D+S LGN+G++CT+T ECQ+ CN

1

GWYADLSASLGNRGSYCTITKECQACCN

28

57.1%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide

Lanthipeptides: EL241_RS01725_lanthipeptide

2

AWYDISCKLGNKGAWCTLTVECQSSCN

28

W D+S LGNKG CTLT ECQ C

2

GWKDLSKSLGNKGYVCTLTKECQKLCR

28

56.7%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

4

YDISCKLGNKGAWCTLTVECQSSCN

28

+ +S LGNKG WCTLT ECQ SCN

6

FTLSDYLGNKGGWCTLTKECQRSCN

30

55.2%

NZ_CP036016.1:

Lanthipeptides: allorf_075467_075682_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSC

27

C W+D+SC LGN G+ CTL+VEC+ +C

2

CTWWDLSCHLGNDGSTCTLSVECRPAC

28

53.6%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

6

ISCKLGNKGAWCTLTVECQSSCN

28

+S KLGN G CTLT ECQ CN

5

LSRKLGNTGYVCTLTKECQRMCN

27

MIBiG 4.0 matches for F5K02_RS03560

82.1%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWY+ISC+LGNKGA+CTLTVEC SCN

1

CAWYNISCRLGNKGAYCTLTVECMPSCN

28

50.0%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

4

YDISCKLGNKGAWCTLTVECQSSCN

28

+ +S LGN G WCTLT ECQ +CN

6

FSLSNALGNNGGWCTLTKECQPNCN

30

20.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

17

CTLTVECQSSCN

28

CTL+ ECQ +CN

28

CTLSKECQPNCN

39

F5K02_RS03570

Leader:

MTKQEKAAIYRDVNKHSELGLESPVGEVNEEELKNLAGA

Core:

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

Core with dehydrations:

KNVNQEEPLDhaDhaFIPGPGDhbCysLDhbAAICysPDhbDhbGMCysNIY

antiSMASH-DB 4.0 matches for F5K02_RS03570

100.0%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13810_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptide

Lanthipeptides: BAMY6639_RS13810_lanthipeptide

1

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

1

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

82.4%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: allorf_0557723_0557881_lanthipeptide

Lanthipeptides: allorf_0557723_0557881_lanthipeptide

2

NVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

NV Q E SSFIPGPGTCLTAAICPTTGMCN Y

2

NVAQNETHSSFIPGPGTCLTAAICPTTGMCNKY

34

34.3%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

2

NVNQEE-PLSSFIPGPGTCLTAAICPTT

28

+VN E P + I G +TA++CPTT

2

DVNPETTPATPTIIGATIAVTASLCPTT

29

with 6 more sequence matches

24.3%

NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17975_lanthipeptide

Lanthipeptides: C794_RS17975_lanthipeptide

5

QEEPLSSFIPGPGTC--LTAAICPTTG

29

++ LS P G+C ++ A CPT+

3

EQNSLSPLTPSSGSCVAISLAFCPTSA

29

23.5%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide

Lanthipeptides: NP440_RS09140_lanthipeptide

20

LTAAICPTTGMCNIY

34

++AAICPTT +I

14

ISAAICPTTQCASIV

28

21.4%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

10

SSFIPGPGTCLTAAICPTT

28

++++ T TAAICPTT

18

TAWVCATVTLATAAICPTT

36

20.9%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS30040_lanthipeptide

Lanthipeptides: K378_RS30040_lanthipeptide

18

TCLTAAICPTT

28

T TAAICPTT

27

TLATAAICPTT

37

18.6%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide

Lanthipeptides: HCC61_RS01465_lanthipeptide

21

TAAICPTT

28

TAAICPTT

30

TAAICPTT

37

17.6%

NZ_BBZF01000020.1:

Lanthipeptides: LPU43_RS18755_lanthipeptide

14

PGPGTCLTAAICPTTGM

30

PGP + + +CP + M

4

PGPASNASVVLCPISVM

20

MIBiG 4.0 matches for F5K02_RS03570

16.2%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

20

LTAAICPTT

28

++AA CPTT

23

VSAAFCPTT

31

11.8%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

24

ICPTT

28

CPTT

16

FCPTT

20

F5K02_RS03575

Leader:

MSNREKAELYRNASKRTELGFVNPVGEVSEDELRNLAGA

Core:

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

Core with dehydrations:

ADVDhbPHDhbDhbPDhaDhaLPCysGVFVDhbAAFCysPDhaDhbKCysDhbDhaDhaCys

antiSMASH-DB 4.0 matches for F5K02_RS03575

100.0%

NZ_CP006058.1and 25 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide

Lanthipeptides: BAMY6639_RS19790_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

78.1%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide

Lanthipeptides: BALI_RS00915_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

ADVTPHTTPSSLPCG VTA +CPS CTS C

1

ADVTPHTTPSSLPCGTLVTAVWCPSNACTSDC

32

65.6%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTPSS+ CG+ V+A FCP+TKCTS C

1

GDVDPQTTPSSVACGIAVSALFCPTTKCTSQC

32

with 123 more sequence matches

Only the first 10 are displayed here.

55.3%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

2

DVTPHTTP---SSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TTP SS C GV V+A+ CP+TKCTS C

2

DVNPETTPATTSSWTCITAGVTVSASLCPTTKCTSRC

38

53.1%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ P V V+ CP+TKCTS C

1

GDVNPETTPAT-PTIVAVSLGICPTTKCTSKC

31

53.1%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

8

TPSSLPCGVFVTAAFCPSTKCTSSC

32

T SS CGV +AAFCPST CTS C

5

TTSSWICGV-ASAAFCPSTACTSKC

28

53.1%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide

Lanthipeptides: C8268_RS00150_lanthipeptide

8

TPSSLPCGVFVTAAFCPSTKCTSSC

32

T SS CG FVTAA CPST CT C

8

TTSSWICG-FVTAALCPSTACTGDC

31

51.3%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

1

ADVTPHTTP---SSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TTP SS PC V ++A CP+TKCTS C

2

GDVNPETTPLTTSSWPCVIGAVDISANLCPTTKCTSKC

39

51.3%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

1

ADVTPHTT---PSSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TT SS C GV V+A+ CP+TKCTS C

2

GDVNPETTILTTSSWTCITAGVTVSASLCPTTKCTSQC

39

48.6%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

1

ADVTPHTTPSS---LPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ + + VTA+ CP+TKCTS C

1

GDVNPETTPATPTIIGATIAVTASLCPTTKCTSRC

35

46.9%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV+P TTP++ V ++ CP+TKCTS C

1

GDVSPETTPATPTIVVAISVGLCPTTKCTSKC

32

46.9%

NZ_CP039292.1and 1 other:

NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide

Lanthipeptides: E4J16_RS14990_lanthipeptide

7

TTPSSLPCGVFVTAAFCPSTKCTSSC

32

TTPSS PCG+ +T CP+ CTS C

2

TTPSSWPCGIGITTTICPTAVCTSKC

27

46.9%

NZ_MLKL01000042.1:

Lanthipeptides: BKK45_RS27405_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ P V V+ CP+ CT SC

1

GDVNPETTPAT-PTIVAVSVKLCPTGVCTKSC

31

MIBiG 4.0 matches for F5K02_RS03575

35.1%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

16

VFVTAAFCPSTKCTSSC

32

V V+AAFCP+TKCTS C

21

VGVSAAFCPTTKCTSRC

37

28.1%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

FCPSTKCTSSC

32

FCP+TKCTS C

16

FCPTTKCTSKC

26

11.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

8

TPSSLPC

14

T SSLPC

42

TLSSLPC

48

allorf_0680979_0681047

Leader:

MNINERYGG

Core:

NRAKKQITNCLNE

Core with dehydrations:

NRAKKQIDhbNCysLNE

antiSMASH-DB 4.0 matches for allorf_0680979_0681047

100.0%

NZ_CP044132.1and 1 other:

NZ_CP044132.1 Lanthipeptides: allorf_0680979_0681047_lanthipeptide

Lanthipeptides: allorf_0680979_0681047_lanthipeptide

1

NRAKKQITNCLNE

13

NRAKKQITNCLNE

1

NRAKKQITNCLNE

13

Lanthipeptide(s) for F5K02_RS03580

F5K02_RS03560

Leader:

MSIIETWKNPALRMNSQVVNPAGDLMEELSDDEMEMLAGG

Core:

CAWYDISCKLGNKGAWCTLTVECQSSCN

Core with dehydrations:

CysAWYDIDhaCysKLGNKGAWCysDhbLDhbVECysQDhaDhaCysN

antiSMASH-DB 4.0 matches for F5K02_RS03560

100.0%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWYDISCKLGNKGAWCTLTVECQSSCN

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

85.7%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWYD+SC+LGNKGAWCTLTVECQ++CN

1

CAWYDVSCRLGNKGAWCTLTVECQNNCN

28

75.0%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSC

27

C WY+ISC+LGNKG WCTLT ECQ SC

1

CEWYNISCQLGNKGQWCTLTKECQRSC

27

with 101 more sequence matches

Only the first 10 are displayed here.

71.9%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWY+ISC+LGNKGA+CTLTVEC SCN

5

CAWYNISCRLGNKGAYCTLTVECMPSCN

32

65.5%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

C W++ISC LGN G +CTLT ECQ SCN

1

CDWWNISCHLGNTGQFCTLTKECQPSCN

28

62.1%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

C W++ISC LGN G +CTLT ECQ +CN

1

CDWWNISCHLGNTGRFCTLTKECQPNCN

28

60.7%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

3

WYDISCKLGNKGAWCTLTVECQSSCN

28

W+++S LGNKG CTLT ECQS CN

1

WWNVSKNLGNKGRICTLTKECQSMCN

26

57.1%

NZ_FOBE01000018.1:

Lanthipeptides: BMW61_RS13085_lanthipeptide

2

AWY-DISCKLGNKGAWCTLTVECQSSCN

28

WY ++S LGN+G++CTLT ECQ+ CN

1

GWYSEMSAALGNRGSYCTLTKECQACCN

28

57.1%

NZ_KE384107.1:

Lanthipeptides: G586_RS23925_lanthipeptide

2

AWY-DISCKLGNKGAWCTLTVECQSSCN

28

WY D+S LGN+G++CT+T ECQ+ CN

1

GWYADLSASLGNRGSYCTITKECQACCN

28

57.1%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide

Lanthipeptides: EL241_RS01725_lanthipeptide

2

AWYDISCKLGNKGAWCTLTVECQSSCN

28

W D+S LGNKG CTLT ECQ C

2

GWKDLSKSLGNKGYVCTLTKECQKLCR

28

56.7%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

4

YDISCKLGNKGAWCTLTVECQSSCN

28

+ +S LGNKG WCTLT ECQ SCN

6

FTLSDYLGNKGGWCTLTKECQRSCN

30

55.2%

NZ_CP036016.1:

Lanthipeptides: allorf_075467_075682_lanthipeptide

1

CAWYDISCKLGNKGAWCTLTVECQSSC

27

C W+D+SC LGN G+ CTL+VEC+ +C

2

CTWWDLSCHLGNDGSTCTLSVECRPAC

28

53.6%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

6

ISCKLGNKGAWCTLTVECQSSCN

28

+S KLGN G CTLT ECQ CN

5

LSRKLGNTGYVCTLTKECQRMCN

27

MIBiG 4.0 matches for F5K02_RS03560

82.1%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

1

CAWYDISCKLGNKGAWCTLTVECQSSCN

28

CAWY+ISC+LGNKGA+CTLTVEC SCN

1

CAWYNISCRLGNKGAYCTLTVECMPSCN

28

50.0%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

4

YDISCKLGNKGAWCTLTVECQSSCN

28

+ +S LGN G WCTLT ECQ +CN

6

FSLSNALGNNGGWCTLTKECQPNCN

30

20.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

17

CTLTVECQSSCN

28

CTL+ ECQ +CN

28

CTLSKECQPNCN

39

F5K02_RS03570

Leader:

MTKQEKAAIYRDVNKHSELGLESPVGEVNEEELKNLAGA

Core:

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

Core with dehydrations:

KNVNQEEPLDhaDhaFIPGPGDhbCysLDhbAAICysPDhbDhbGMCysNIY

antiSMASH-DB 4.0 matches for F5K02_RS03570

100.0%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13810_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03325_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12915_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18405_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14700_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03570_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03175_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03405_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03210_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03230_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10975_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15465_lanthipeptide

Lanthipeptides: BAMY6639_RS13810_lanthipeptide

1

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

1

KNVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

82.4%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: allorf_0557723_0557881_lanthipeptide

Lanthipeptides: allorf_0557723_0557881_lanthipeptide

2

NVNQEEPLSSFIPGPGTCLTAAICPTTGMCNIY

34

NV Q E SSFIPGPGTCLTAAICPTTGMCN Y

2

NVAQNETHSSFIPGPGTCLTAAICPTTGMCNKY

34

34.3%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

2

NVNQEE-PLSSFIPGPGTCLTAAICPTT

28

+VN E P + I G +TA++CPTT

2

DVNPETTPATPTIIGATIAVTASLCPTT

29

with 6 more sequence matches

24.3%

NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17975_lanthipeptide

Lanthipeptides: C794_RS17975_lanthipeptide

5

QEEPLSSFIPGPGTC--LTAAICPTTG

29

++ LS P G+C ++ A CPT+

3

EQNSLSPLTPSSGSCVAISLAFCPTSA

29

23.5%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide

Lanthipeptides: NP440_RS09140_lanthipeptide

20

LTAAICPTTGMCNIY

34

++AAICPTT +I

14

ISAAICPTTQCASIV

28

21.4%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

10

SSFIPGPGTCLTAAICPTT

28

++++ T TAAICPTT

18

TAWVCATVTLATAAICPTT

36

20.9%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: K378_RS30040_lanthipeptide

Lanthipeptides: K378_RS30040_lanthipeptide

18

TCLTAAICPTT

28

T TAAICPTT

27

TLATAAICPTT

37

18.6%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS01465_lanthipeptide

Lanthipeptides: HCC61_RS01465_lanthipeptide

21

TAAICPTT

28

TAAICPTT

30

TAAICPTT

37

17.6%

NZ_BBZF01000020.1:

Lanthipeptides: LPU43_RS18755_lanthipeptide

14

PGPGTCLTAAICPTTGM

30

PGP + + +CP + M

4

PGPASNASVVLCPISVM

20

MIBiG 4.0 matches for F5K02_RS03570

16.2%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

20

LTAAICPTT

28

++AA CPTT

23

VSAAFCPTT

31

11.8%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

24

ICPTT

28

CPTT

16

FCPTT

20

F5K02_RS03575

Leader:

MSNREKAELYRNASKRTELGFVNPVGEVSEDELRNLAGA

Core:

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

Core with dehydrations:

ADVDhbPHDhbDhbPDhaDhaLPCysGVFVDhbAAFCysPDhaDhbKCysDhbDhaDhaCys

antiSMASH-DB 4.0 matches for F5K02_RS03575

100.0%

NZ_CP006058.1and 25 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide

Lanthipeptides: BAMY6639_RS19790_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

78.1%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide

Lanthipeptides: BALI_RS00915_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

ADVTPHTTPSSLPCG VTA +CPS CTS C

1

ADVTPHTTPSSLPCGTLVTAVWCPSNACTSDC

32

65.6%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTPSS+ CG+ V+A FCP+TKCTS C

1

GDVDPQTTPSSVACGIAVSALFCPTTKCTSQC

32

with 123 more sequence matches

Only the first 10 are displayed here.

55.3%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

2

DVTPHTTP---SSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TTP SS C GV V+A+ CP+TKCTS C

2

DVNPETTPATTSSWTCITAGVTVSASLCPTTKCTSRC

38

53.1%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ P V V+ CP+TKCTS C

1

GDVNPETTPAT-PTIVAVSLGICPTTKCTSKC

31

53.1%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

8

TPSSLPCGVFVTAAFCPSTKCTSSC

32

T SS CGV +AAFCPST CTS C

5

TTSSWICGV-ASAAFCPSTACTSKC

28

53.1%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00150_lanthipeptide

Lanthipeptides: C8268_RS00150_lanthipeptide

8

TPSSLPCGVFVTAAFCPSTKCTSSC

32

T SS CG FVTAA CPST CT C

8

TTSSWICG-FVTAALCPSTACTGDC

31

51.3%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

1

ADVTPHTTP---SSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TTP SS PC V ++A CP+TKCTS C

2

GDVNPETTPLTTSSWPCVIGAVDISANLCPTTKCTSKC

39

51.3%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

1

ADVTPHTT---PSSLPC---GVFVTAAFCPSTKCTSSC

32

DV P TT SS C GV V+A+ CP+TKCTS C

2

GDVNPETTILTTSSWTCITAGVTVSASLCPTTKCTSQC

39

48.6%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

1

ADVTPHTTPSS---LPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ + + VTA+ CP+TKCTS C

1

GDVNPETTPATPTIIGATIAVTASLCPTTKCTSRC

35

46.9%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV+P TTP++ V ++ CP+TKCTS C

1

GDVSPETTPATPTIVVAISVGLCPTTKCTSKC

32

46.9%

NZ_CP039292.1and 1 other:

NZ_CP039292.1 Lanthipeptides: E4J16_RS14990_lanthipeptide

Lanthipeptides: E4J16_RS14990_lanthipeptide

7

TTPSSLPCGVFVTAAFCPSTKCTSSC

32

TTPSS PCG+ +T CP+ CTS C

2

TTPSSWPCGIGITTTICPTAVCTSKC

27

46.9%

NZ_MLKL01000042.1:

Lanthipeptides: BKK45_RS27405_lanthipeptide

1

ADVTPHTTPSSLPCGVFVTAAFCPSTKCTSSC

32

DV P TTP++ P V V+ CP+ CT SC

1

GDVNPETTPAT-PTIVAVSVKLCPTGVCTKSC

31

MIBiG 4.0 matches for F5K02_RS03575

35.1%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

16

VFVTAAFCPSTKCTSSC

32

V V+AAFCP+TKCTS C

21

VGVSAAFCPTTKCTSRC

37

28.1%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

FCPSTKCTSSC

32

FCP+TKCTS C

16

FCPTTKCTSKC

26

11.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

8

TPSSLPC

14

T SSLPC

42

TLSSLPC

48

allorf_0680979_0681047

Leader:

MNINERYGG

Core:

NRAKKQITNCLNE

Core with dehydrations:

NRAKKQIDhbNCysLNE

antiSMASH-DB 4.0 matches for allorf_0680979_0681047

100.0%

NZ_CP044132.1and 1 other:

NZ_CP044132.1 Lanthipeptides: allorf_0680979_0681047_lanthipeptide

Lanthipeptides: allorf_0680979_0681047_lanthipeptide

1

NRAKKQITNCLNE

13

NRAKKQITNCLNE

1

NRAKKQITNCLNE

13

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.43 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.03 out of 24.78

Confidence: medium

Additional weak hits (1):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.94 out of 29.65

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

F5K02_RS03495 - Class II

Cleavage pHMM score: -5.10

RODEO score: 0

Monoisotopic mass: 5305.6 Da

Molecular weight: 5308.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5326.9 Da N = 1; 5344.9 Da N = 2; 5362.9 Da N = 3; 5380.9 Da N = 4

F5K02_RS03560 - Class II

Cleavage pHMM score: 2.80

RODEO score: 0

Monoisotopic mass: 2992.3 Da

Molecular weight: 2994.4 Da

Number of bridges: 5

F5K02_RS03570 - Class II

Cleavage pHMM score: 3.70

RODEO score: 0

Monoisotopic mass: 3460.7 Da

Molecular weight: 3463.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3481.0 Da N = 1; 3499.0 Da N = 2; 3517.0 Da N = 3

F5K02_RS03575 - Class II

Cleavage pHMM score: 3.80

RODEO score: 0

Monoisotopic mass: 3016.4 Da

Molecular weight: 3018.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3036.4 Da N = 1; 3054.5 Da N = 2; 3072.5 Da N = 3; 3090.5 Da N = 4; 3108.5 Da N = 5; 3126.5 Da N = 6; 3144.6 Da N = 7

allorf_0680979_0681047 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 1512.8 Da

Molecular weight: 1513.7 Da

Number of bridges: 1

F5K02_RS03560 - Class II

Cleavage pHMM score: 2.80

RODEO score: 0

Monoisotopic mass: 2992.3 Da

Molecular weight: 2994.4 Da

Number of bridges: 5

F5K02_RS03570 - Class II

Cleavage pHMM score: 3.70

RODEO score: 0

Monoisotopic mass: 3460.7 Da

Molecular weight: 3463.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3481.0 Da N = 1; 3499.0 Da N = 2; 3517.0 Da N = 3

F5K02_RS03575 - Class II

Cleavage pHMM score: 3.80

RODEO score: 0

Monoisotopic mass: 3016.4 Da

Molecular weight: 3018.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3036.4 Da N = 1; 3054.5 Da N = 2; 3072.5 Da N = 3; 3090.5 Da N = 4; 3108.5 Da N = 5; 3126.5 Da N = 6; 3144.6 Da N = 7

allorf_0680979_0681047 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 1512.8 Da

Molecular weight: 1513.7 Da

Number of bridges: 1

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_CP044132.1 - Region 4 - PKS-like

Download region GenBank file

Download region SVG

Location: 1,029,463 - 1,070,707 nt. (total: 41,245 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

F5K02_RS05275: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase

F5K02_RS05305: acyltransferase

smcogs: SMCOG1141: acyltransferase

F5K02_RS05320: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: deacetylase

F5K02_RS05365: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: synthase

F5K02_RS05325: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

F5K02_RS05280: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.50	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0002294.3	0.43	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0001292.5	0.42	other (other)	A33853	Streptomyces sp. NRRL 12068
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.50	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0002294.3	0.43	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0001292.5	0.42	other (other)	A33853	Streptomyces sp. NRRL 12068
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 25.45 out of 27.55

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.81 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.49 out of 25.88

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.85 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19

Confidence: medium

Additional weak hits (11):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.34 out of 30.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.42 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator
ZuR variant 1	Zinc-responsive repressor

NZ_CP044132.1 - Region 5 - terpene

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Location: 1,153,507 - 1,174,247 nt. (total: 20,741 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

F5K02_RS05915: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000885.3	0.43	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.41	other (other)	tabtoxin	Pseudomonas syringae
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001374.5	0.35	other (other)	thienodolin	Streptomyces albogriseolus
BGC0000937.5	0.31	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0001007.5	0.30	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin b	Salinispora arenicola CNS-205
BGC0000254.5	0.30	PKS	oxytetracycline	Streptomyces rimosus
BGC0001739.3	0.29	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001006.5	0.29	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin B	Salinispora tropica CNB-440
BGC0000190.5	0.29	PKS	A-74528	Streptomyces sp. SANK 61196

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000885.3	0.43	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.41	other (other)	tabtoxin	Pseudomonas syringae
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001374.5	0.35	other (other)	thienodolin	Streptomyces albogriseolus
BGC0000937.5	0.31	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0001007.5	0.30	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin b	Salinispora arenicola CNS-205
BGC0000254.5	0.30	PKS	oxytetracycline	Streptomyces rimosus
BGC0001739.3	0.29	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001006.5	0.29	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin B	Salinispora tropica CNB-440
BGC0000190.5	0.29	PKS	A-74528	Streptomyces sp. SANK 61196

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		PSPP	C30	acyclic	PP
triterpene		squalene	C30	acyclic	none
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

F5K02_RS05920: PT_phytoene_like

Domain 1 (3 - 242): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → PSPP; FPP → squalene; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 20.47 out of 20.47

Confidence: strong

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.23 out of 20.97

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.27 out of 27.78

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.29 out of 27.55

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.46 out of 27.78

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.99 out of 35.63

Confidence: medium

Additional weak hits (3):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.91 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
NrtR	NAD synthesis repressor
RutR	Regulator of the pyrimidine and purine metabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP044132.1 - Region 6 - transAT-PKS

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Location: 1,482,680 - 1,570,905 nt. (total: 88,226 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

F5K02_RS07800: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS07810: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS07815: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS07825: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS07855: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acylase kinase

F5K02_RS07695: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

F5K02_RS07795: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase deformylase hydrolase phosphatase

F5K02_RS07775: hydrolase

smcogs: SMCOG1179: hydrolase

F5K02_RS07780: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

F5K02_RS07830: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

F5K02_RS07835: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

F5K02_RS07865: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

F5K02_RS07895: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Ligases: synthase

F5K02_RS07805: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

F5K02_RS07845: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.92	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.92	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.92	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.92	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.63 out of 27.78

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55

Confidence: medium

Additional weak hits (7):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.56 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.20 out of 31.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 8, location 1482679 - 1570905:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:: F5K02_RS07800 + F5K02_RS07805 + F5K02_RS07810 + F5K02_RS07815 + F5K02_RS07820 + F5K02_RS07825 + F5K02_RS07830

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F5K02_RS07795: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 91.9
inactive: 31.2
Methoxymalonyl-CoA: 26.1
Methylmalonyl-CoA: 19.6
Propionyl-CoA: 16.9
fatty_acid: 13.9
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT	Regulator of MSHA biosynthesis

NZ_CP044132.1 - Region 7 - NRPS,T3PKS,transAT-PKS

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Location: 1,796,934 - 1,907,039 nt. (total: 110,106 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

F5K02_RS09040: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

F5K02_RS09170: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS09190: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase

F5K02_RS09130: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

F5K02_RS09135: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

F5K02_RS09140: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase protease

F5K02_RS09125: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

F5K02_RS09210: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase

F5K02_RS09155: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

F5K02_RS09160: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

F5K02_RS09045: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

F5K02_RS09150: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

F5K02_RS09165: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

F5K02_RS09175: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

F5K02_RS09180: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

F5K02_RS09185: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	1.67	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0001160.5	1.03	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002135.2	1.03	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001164.3	1.01	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001132.4	0.97	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.97	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.97	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.96	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.94	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.94	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	0.92	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.69	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.14 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.10 out of 24.78

Confidence: strong

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.35 out of 27.04

Confidence: medium

Additional weak hits (14):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.07 out of 39.62

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.46 out of 21.55

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 9, location 1796933 - 1907039:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F5K02_RS09130: mal

PKS_AT (4..285): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 100.0
inactive: 46.8
Methoxymalonyl-CoA: 38.9
Methylmalonyl-CoA: 25.3
Propionyl-CoA: 23.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

F5K02_RS09135: mal

PKS_AT (7..293): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 31.8
inactive: 25.8
Methoxymalonyl-CoA: 14.0
Benzoyl-CoA: 13.9
Isobutyryl-CoA: 8.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

F5K02_RS09140: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 93.3
inactive: 29.5
Methoxymalonyl-CoA: 23.7
Methylmalonyl-CoA: 10.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

F5K02_RS09165: fatty_acid - Gly

Search NORINE for peptide: strict or relaxed

CAL_domain (74..476): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 26.7
NH2: 9.4
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (1145..1540): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDIAALELQALCGGEWNMFGPTETTIWSAV
Nearest Stachelhaus code(s):: Gly DILQLGMIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS09180: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (492..896): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
DasR	N-acetylglucosamine dependent repressor
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP044132.1 - Region 8 - NRPS,betalactone,transAT-PKS

Download region GenBank file

Download region SVG

Location: 2,104,023 - 2,241,841 nt. (total: 137,819 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

F5K02_RS10590: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

F5K02_RS10605: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS10690: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS10710: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

F5K02_RS10785: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

F5K02_RS10885: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acylase aminotransferase carboxylase transferase

F5K02_RS10685: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

F5K02_RS10730: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

F5K02_RS10745: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

F5K02_RS10755: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

F5K02_RS10775: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase

F5K02_RS10860: gamma-glutamyltranspeptidase

smcogs: SMCOG1274: gamma-glutamyltranspeptidase

Lyases: hydratase

F5K02_RS10760: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

F5K02_RS10670: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

F5K02_RS10675: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F5K02_RS10680: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

F5K02_RS10725: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

F5K02_RS10765: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

F5K02_RS10780: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F5K02_RS10800: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

F5K02_RS10805: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F5K02_RS10810: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F5K02_RS10815: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F5K02_RS10820: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001098.5	1.65	NRPS, PKS	iturin	Bacillus subtilis
BGC0002135.2	1.59	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	1.58	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001095.5	1.55	NRPS	fengycin	Bacillus velezensis FZB42
BGC0001090.5	1.53	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001128.4	1.51	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	1.49	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	1.49	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	1.49	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135.5	1.47	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001095.5	0.93	NRPS	fengycin	Bacillus velezensis FZB42
BGC0001098.5	0.90	NRPS, PKS	iturin	Bacillus subtilis
BGC0001090.5	0.88	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0000407.5	0.81	NRPS	plipastatin	Bacillus subtilis subsp. subtilis
BGC0000402.4	0.81	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430
BGC0001103.5	0.79	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.75	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.59 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.57 out of 27.78

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.44 out of 32.93

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.67 out of 20.01

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.82 out of 26.06

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.75 out of 26.85

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (16):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.46 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.66 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.12 out of 27.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.79 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.75 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.41 out of 29.38

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.96 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.50 out of 26.06

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.24 out of 27.18

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 10, location 2104022 - 2241841:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile) + (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Gln - Pro - D-Asn) + (Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 11, location 2104022 - 2181267:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Gln - Pro - D-Asn) + (Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 12, location 2164171 - 2241841:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F5K02_RS10670: Asn - Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (268..663): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTITSTKLIVGGDFNEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1778..2185): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS10675: Tyr - Asn - Gln - Pro

Search NORINE for peptide: strict or relaxed

AMP-binding (268..662): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: SWKYFDAFILNGSTVVGGENNEYGPTENSVVSSF
Nearest Stachelhaus code(s):: Tyr DALSVGEVVK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1779..2174): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3288..3693): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASVQQADGLIGGETNVYGPTETCVDASL
Nearest Stachelhaus code(s):: Gln DAQDLGVVDK (100% 8Å match); Ile DAQDLGVVDK (74% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4337..4733): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LYEAFDVCYQESFLIAAGEHNHYGPSETHVVTMY
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS10680: fatty_acid - Asn

Search NORINE for peptide: strict or relaxed

CAL_domain (36..478): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 625.8
NH2: 18.0
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (2956..3351): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGEFNEYGPTEAVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS10685: mal

PKS_AT (6..290): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 75.7
inactive: 30.0
Methoxymalonyl-CoA: 20.4
Propionyl-CoA: 11.8
Methylmalonyl-CoA: 11.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

F5K02_RS10780: X

AMP-binding (12..445): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
Nearest Stachelhaus code(s):: Z-ahmohOrn FGLHIASTCK (56% 8Å match); Ile DGLFIGIPVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

F5K02_RS10800: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (473..866): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
Nearest Stachelhaus code(s):: Ile DAFFYGITFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS10805: Pro - Gln - Tyr

Search NORINE for peptide: strict or relaxed

AMP-binding (469..866): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LHQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1500..1901): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: FSLTFDASIWEWHFFAGGETNSYGPTEATVEAAY
Nearest Stachelhaus code(s):: Gln DAWHFGSVEK (100% 8Å match); Glu DAWHFGSVEK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2532..2924): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: TWRFFDGFVTSTIITLAGEANEYGPTENSVATTA
Nearest Stachelhaus code(s):: Tyr DGTITAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS10810: Glu - X

Search NORINE for peptide: strict or relaxed

AMP-binding (468..873): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
Nearest Stachelhaus code(s):: Glu DAWHFGGVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1505..1898): X

nrpys: Ala, Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LNSSFDVTTFEGWLIIGGEWNGYGPTENTTFSTC
Nearest Stachelhaus code(s):: Ala or Val DVFWIGGTFK (97% 8Å match); Val DVFWIGGTFK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS10815: Tyr - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (474..867): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: TWRFFDGSLTSTLITFAGELNEYGPTENSVATTI
Nearest Stachelhaus code(s):: Tyr DGTLTAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1509..1905): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LHKHFDFSVWEGNQIFGGEVNMYGITETTVHVTC
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS10820: Glu - Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (463..868): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
Nearest Stachelhaus code(s):: Glu DAWHFGGVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1500..1905): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: AAWAFDVFSGDRESVLGSDINSYGVTEATIDSSY
Nearest Stachelhaus code(s):: Orn DVGEVGSIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
ArgR	Regulator of arginine biosynthesis genes
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
RutR	Regulator of the pyrimidine and purine metabolism
ToxT	Regulator of MSHA biosynthesis

NZ_CP044132.1 - Region 9 - terpene

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Location: 2,267,123 - 2,289,006 nt. (total: 21,884 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

F5K02_RS11115: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Hydrolases: hydrolase

F5K02_RS11140: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0000607.5	0.32	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000686.3	0.30	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001575.4	0.29	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001338.4	0.28	PKS	citrinin	Monascus ruber
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0000607.5	0.32	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000686.3	0.30	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001575.4	0.29	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001338.4	0.28	PKS	citrinin	Monascus ruber
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

F5K02_RS11120: T2TS

Domain 1 (5 - 625): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.14 out of 18.16

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.86 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.92 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

Additional weak hits (5):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.37 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.54 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP044132.1 - Region 10 - T3PKS

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Location: 2,357,078 - 2,398,178 nt. (total: 41,101 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

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TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase methyltransferase

F5K02_RS11710: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

F5K02_RS11720: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase

F5K02_RS11740: isochorismatase

smcogs: SMCOG1027: isochorismatase

Ligases: synthase

F5K02_RS11715: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.55	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001475.4	0.43	terpene	aspterric acid	Aspergillus terreus NIH2624
BGC0001289.5	0.35	ribosomal	penisin	Paenibacillus ehimensis
BGC0001647.3	0.34	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0002254.3	0.33	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0001964.2	0.33	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0001928.2	0.32	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001663.3	0.32	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.55	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001475.4	0.43	terpene	aspterric acid	Aspergillus terreus NIH2624
BGC0001289.5	0.35	ribosomal	penisin	Paenibacillus ehimensis
BGC0001647.3	0.34	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0002254.3	0.33	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0001964.2	0.33	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0001928.2	0.32	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001663.3	0.32	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.98 out of 20.97

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.73 out of 29.25

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.26 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.26 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.39 out of 27.78

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.10 out of 32.93

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.96 out of 24.78

Confidence: medium

Additional weak hits (11):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.42 out of 28.14

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.07 out of 30.22

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.45 out of 29.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.23 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.58 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.01 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.96 out of 32.74

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.59 out of 30.97

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.18 out of 25.75

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.96 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
LexA variant 2	Repressor of DNA damage response
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP044132.1 - Region 11 - transAT-PKS

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Location: 2,513,917 - 2,620,096 nt. (total: 106,180 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

F5K02_RS12515: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

F5K02_RS12595: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS12620: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

F5K02_RS12625: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

F5K02_RS12635: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS12640: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS12655: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS12660: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS12695: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

F5K02_RS12720: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: acylase transferase

F5K02_RS12680: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

F5K02_RS12745: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: deacetylase hydrolase

F5K02_RS12600: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

F5K02_RS12740: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Lyases: hydratase

F5K02_RS12610: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

F5K02_RS12615: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

F5K02_RS12630: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

F5K02_RS12645: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

F5K02_RS12665: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.93	PKS	difficidin	Bacillus velezensis FZB42
BGC0000174.5	0.67	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001383.3	0.58	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0002056.3	0.58	NRPS, PKS	peloruside A	sponge metagenome
BGC0001795.3	0.56	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0000067.5	0.54	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001012.3	0.53	NRPS, PKS	meridamycin	Streptomyces violaceusniger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.93	PKS	difficidin	Bacillus velezensis FZB42
BGC0000174.5	0.67	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001383.3	0.58	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0002056.3	0.58	NRPS, PKS	peloruside A	sponge metagenome
BGC0001795.3	0.56	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0000067.5	0.54	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001012.3	0.53	NRPS, PKS	meridamycin	Streptomyces violaceusniger

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.92 out of 27.78

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.93 out of 27.55

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.96 out of 24.78

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.92 out of 25.88

Confidence: medium

Additional weak hits (9):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.71 out of 30.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.13 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.34 out of 26.06

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.46 out of 30.97

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.31 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 15, location 2513916 - 2620096:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal - ccmal - mal) + (ohmal - mal) + (mal) + (ccmal - ccmal - ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:: F5K02_RS12655 + F5K02_RS12650 + F5K02_RS12645 + F5K02_RS12640 + F5K02_RS12635 + F5K02_RS12630 + F5K02_RS12625

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F5K02_RS12665: X

AMP-binding (15..363): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ALLLHIGGINTAPATYGTEKQTYGLTELGIFSTK
Nearest Stachelhaus code(s):: 2,3-dohHda IGNPTGTIMK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

F5K02_RS12680: mal

PKS_AT (4..281): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 86.6
Methoxymalonyl-CoA: 24.9
inactive: 23.4
2-Methylbutyryl-CoA: 14.3
Methylmalonyl-CoA: 14.1
Propionyl-CoA: 13.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
LexA variant 2	Repressor of DNA damage response
MexT	Global virulence regulator
PsrA	Oleic acid responsive regulator
ToxT	Regulator of MSHA biosynthesis

NZ_CP044132.1 - Region 12 - terpene-precursor

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Location: 2,642,191 - 2,663,081 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

F5K02_RS12980: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

F5K02_RS12945: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

F5K02_RS12950: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

F5K02_RS12950: PT_FPPS_like

Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.81 out of 29.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
SypG	Regulator of biofilm formation and host colonization

NZ_CP044132.1 - Region 13 - NRP-metallophore,NRPS,RiPP-like,terpene-precursor

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Location: 3,245,981 - 3,311,298 nt. (total: 65,318 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

F5K02_RS16225: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS16300: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS16350: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

F5K02_RS16355: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

F5K02_RS16405: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: esterase hydrolase

F5K02_RS16145: thioesterase superfamily protein

smcogs: SMCOG1144: thioesterase superfamily protein

F5K02_RS16190: isochorismatase

smcogs: SMCOG1027: isochorismatase

F5K02_RS16285: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

F5K02_RS16295: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthetase

F5K02_RS16165: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

F5K02_RS16280: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

F5K02_RS16290: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	2.51	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	1.64	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	1.05	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	1.04	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.87	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.86	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.75	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	0.96	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	0.94	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.80	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.80	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

F5K02_RS16165: PT_FPPS_like

Domain 1 (56 - 285): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.57 out of 27.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.00 out of 26.06

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.87 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.23 out of 21.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

Additional weak hits (20):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.56 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.36 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.99 out of 33.14

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 17, location 3245980 - 3311298:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 19, location 3259507 - 3311243:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F5K02_RS16280: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (456..855): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1513..1929): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

F5K02_RS16290: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SISLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (100% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP044132.1 - Region 14 - other

Download region GenBank file

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Location: 3,842,622 - 3,884,040 nt. (total: 41,419 nt) Show pHMM detection rules used

other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

F5K02_RS19240: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS19260: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F5K02_RS19295: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase transferase

F5K02_RS19245: aminotransferase

smcogs: SMCOG1019: aminotransferase

F5K02_RS19325: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

F5K02_RS19350: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: dehydratase lyase

F5K02_RS19255: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

F5K02_RS19315: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

F5K02_RS19320: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease

F5K02_RS19150: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

F5K02_RS19285: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001184.4	0.98	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000888.5	0.96	other (other)	bacilysin	Bacillus sp. CS93
BGC0000898.5	0.56	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000790.3	0.55	saccharide	O-antigen	Escherichia coli
BGC0000773.3	0.55	saccharide	lipopolysaccharide	Escherichia coli
BGC0000791.3	0.54	saccharide	O-antigen	Cronobacter sakazakii
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000795.3	0.52	saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000899.4	0.52	saccharide	desosamine	Streptomyces narbonensis
BGC0001817.5	0.52	other (other)	vancosamine	Streptomyces sp. WAC2288

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001184.4	0.98	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000888.5	0.96	other (other)	bacilysin	Bacillus sp. CS93
BGC0000898.5	0.56	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000790.3	0.55	saccharide	O-antigen	Escherichia coli
BGC0000773.3	0.55	saccharide	lipopolysaccharide	Escherichia coli
BGC0000791.3	0.54	saccharide	O-antigen	Cronobacter sakazakii
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000795.3	0.52	saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000899.4	0.52	saccharide	desosamine	Streptomyces narbonensis
BGC0001817.5	0.52	other (other)	vancosamine	Streptomyces sp. WAC2288

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.03 out of 26.85

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.63 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.12 out of 23.79

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.75 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.47 out of 28.19

Confidence: medium

Additional weak hits (8):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.29 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.15 out of 36.54

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.45 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.50 out of 30.22

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.62 out of 32.93

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.32 out of 26.06

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
RutR	Regulator of the pyrimidine and purine metabolism
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor