LOCUS       NZ_CP092779            25388 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Paenibacillus polymyxa strain ZJ-9 chromosome, complete genome.
ACCESSION   NZ_CP092779
VERSION     NZ_CP092779.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5755887)
  AUTHORS   Zhang,Y. and Gao,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2022) School of Chemistry and Chemical
            Engineering, Yancheng Institute of Technology, 211 Jianjun East
            Road, Yancheng, Jiangsu Province 224051, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 265.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022492955.1-RS_2024_03_30
            Annotation Date                   :: 03/30/2024 06:30:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,104
            CDSs (total)                      :: 4,947
            Genes (coding)                    :: 4,884
            CDSs (with protein)               :: 4,884
            Genes (RNA)                       :: 157
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 111
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 34 of 63
            Pseudo Genes (incomplete)         :: 30 of 63
            Pseudo Genes (internal stop)      :: 14 of 63
            Pseudo Genes (multiple problems)  :: 12 of 63
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:24:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4386835
            Orig. end                         :: 4412223
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP092779.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jian Gao, 211 Jianjun East
            Road, Yancheng City, Jiangsu Province.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25388
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="19"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..25388
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25388
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15388](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15388)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            933..1973
                     /locus_tag="MJ749_RS19165"
                     /old_locus_tag="MJ749_19165"
     CDS             933..1973
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688423.1"
                     /locus_tag="MJ749_RS19165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19165"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_025365660.1"
                     /transl_table=11
                     /translation="MNIKTIASMAGVSVATVSKIINNYTDISEETRQRVLKIMEETGYR
                     PSSSAKTLATKKSNLVGVIFAGKLNVDFSHPFFVDIINVFKKQIGLLGYDLLFFSNEKF
                     LDNGEDYLARSKYFSVDGCIIIAGDEVEKSVFDLDASPIPCIGVDIELTGASSCYIMSD
                     NQKISMKVVEHFYMNGYREMGFIGIERPSLVIKEREEAFISSLKRFSLDVRPEWIVYGK
                     DYAAEDGYQIAKAWIEQENLPRAIFAATDLLAFGAIRAFKESGLRVPEDIAVVGCDDIE
                     ACRYTDPPLTTVKQDKQKIGRLAAMVLFDLMNKQMDTKCIKVEPELVIRTSCGARQHWN
                     PTRVEG"
     gene            complement(2058..3551)
                     /gene="glpK"
                     /locus_tag="MJ749_RS19170"
                     /old_locus_tag="MJ749_19170"
     CDS             complement(2058..3551)
                     /EC_number="2.7.1.30"
                     /GO_function="GO:0004370 - glycerol kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glpK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1210: glycerol kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818622.1"
                     /locus_tag="MJ749_RS19170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19170"
                     /product="glycerol kinase GlpK"
                     /protein_id="WP_240753200.1"
                     /transl_table=11
                     /translation="MGKYILSLDQGTTSSRAILFNSEGDVVYSAQREFPQYFPHPGWVE
                     QNANEIWSSILGVIASCLSESGVKAKQIAAIGITNQRESVAVWDKNTGLPVYNVLVWQS
                     RQTSDICEELKRQGHEELFHSKTGLLIDPYFSGTKVKWILDHVEGARERAERGDLLFGT
                     IDSWLIWKLSGGKAHVTDYSNAARTLMYNIYELKWDEELLDILGVPKIMLPEVRPSSEV
                     YAHTVDYHFFGQNVPIAGAAGDQQAALFGQACYEKGMIKNTYGTGCFMLMNTGDQPVES
                     KHGLITTIAWGLEEGKVQYALEGSVFVAGSAIQWLRDGLRMFREAKDSEPYAARVSSTE
                     GVYLVPAFVGLGSPYWDSEVRGAMFGLTRGTTKEHFIRATLESLAYQTKDVLTAMEIDS
                     GIAVKTLRVDGGAVLNNFLMQFQSDILDATVERPVIHETTALGAACLAGLAIGYWKSTD
                     ELRKRVRVETSFTPTMDEATRDSLYEGWKKAVNATMAYK"
     gene            complement(3583..4407)
                     /locus_tag="MJ749_RS19175"
                     /old_locus_tag="MJ749_19175"
     CDS             complement(3583..4407)
                     /GO_function="GO:0015267 - channel activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688424.1"
                     /locus_tag="MJ749_RS19175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19175"
                     /product="MIP/aquaporin family protein"
                     /protein_id="WP_045244841.1"
                     /transl_table=11
                     /translation="MSPYAAEFIGTMILIALGGGVCAGVSLKKSFAHASGWIVVGLGWG
                     LAVAIGVYAVGQISGAHLNPAVTLALAFQGSFPWQDVPGYIVAQVLGAMAGAVIVILHY
                     WPHWKETEDTAAKLSVFATGPAIDHPFGNVLSEMIGTFIFVLALLSFGANSFTDGLKPL
                     IVGFLVVSIGLSLGGTTGYAINPARDFGPRLMHYLLPIPGKGASNWKYAWVPIVGPLLG
                     GSFAGPFYQAVFKGSMTPAFWILLGVIVVVLLITFGISRIYKNHKMDHKLTA"
     misc_feature    4363..4378
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 23.4"
                     /tool="antismash"
     gene            4729..6210
                     /locus_tag="MJ749_RS19180"
                     /old_locus_tag="MJ749_19180"
     CDS             4729..6210
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1145: Glucose-specific phosphotransferase enzyme IIA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372703.1"
                     /locus_tag="MJ749_RS19180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19180"
                     /product="PTS transporter subunit EIIC"
                     /protein_id="WP_151255967.1"
                     /transl_table=11
                     /translation="MLKFLQKIGKSLMLPVATLPAAGILQGLALINYETDIPLGPGVGG
                     FLNHYVTPFLNEGAGAIFGNLALIFSIGVAIGLAGDAVAALSAVIAYLVLTRILAAVPG
                     IFAYIPDDVKLDMGVLGGIFIGGWSAYLFKKYHNIQLPDWLGFFSGKRFVPMITAFTTM
                     ILAILLGMIWSPIQDGIAAFGNWIVGFGGIGSMVFMIANRLLIPLGLHHVLNSIAWFQI
                     GDYTNAAGEVVHGDLTRFFAGDTSAGMFMSGFFPIMMFALPAAALAFIHTAKPEKRKAV
                     ASIFIGSALASFLTGITEPLEFSFMFIAPLLYGVHALLTGLSGLVVYLLDVKLGFSFSA
                     GLIDYLVNMKLSTHPLRMIPIGLVFAFIYYFLFRFIILKFNLKTPGREDDVDDTLLFEA
                     NKSIPVGKTSASSGTQSSQAGQVLTYLGGSDNIQSIDACITRLRLVVKDDKAVNDQALK
                     QLGASGIIRLGNGTLQVIFGTRSEALKDEIQRLMS"
     gene            6408..7697
                     /locus_tag="MJ749_RS19185"
                     /old_locus_tag="MJ749_19185"
     CDS             6408..7697
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014277625.1"
                     /locus_tag="MJ749_RS19185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19185"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_240753213.1"
                     /transl_table=11
                     /translation="MKTVQWQWLVLCLAFLTMISGCSGSLSSKGQSSEANLSNSKKITL
                     TLWYWNRSIDDELLVQAEKQFPNIELKTQKIGGDFKAKLKTTLAARSGEPDIVALNDWM
                     VELFPSADRFYDLKELGADRLKDQYLEWKWNQGITPDGKMIAFPMDTGPTALFYRSDLF
                     EQAGLPSDPEQVSASIRTWDDYMAAGEQLRQKFGSHSFLADNIVNVYNQVLAQHTNLYF
                     KPDGSYIGNQSPDIRLGWKTAVDFHRKHLLANADGWTPEWNASVNNGKIASFVGAIWMK
                     QVLTEAAPDTAGKWRVARAPGGDGNLGGSFISILKSSQHPKEAFEVLTWLQSPEHQLEA
                     YHKIGLFPSTPGVYDDPVMETPEPFFGGQATGLIFAASARQVKNSYFGERYPVIHGIVT
                     RRLANVAKQNADPDSLWTETMQRIERELQR"
     gene            7731..8606
                     /locus_tag="MJ749_RS19190"
                     /old_locus_tag="MJ749_19190"
     CDS             7731..8606
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014277626.1"
                     /locus_tag="MJ749_RS19190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19190"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_016818618.1"
                     /transl_table=11
                     /translation="MLREIWKHRAVYAAISPFYLLFGIFGLFPIGFSLYLAFHKWDGIG
                     DMTYNGWGNFRYLVTDNEFWQAVGNTFVIWVYATIPMLFLALIVAFLLYAPFVKMRTLW
                     RVGFFLPNVTSIVAVAIIFGALFANNFGFLNYLLQLLGLPMIQWLNVPWGIQIAISSMV
                     VWRWMGYNAIIYLAGLQSIPHVLYEAAKIDGATGAQAFFRITIPMLRPVILFTVITSTI
                     GGMQLFTEPQVLVGNDGGAGASGMTIVLYLYRESFINNYFGYGAAVGWGMFLIIALFSI
                     INWKLVQGKK"
     gene            8628..9455
                     /locus_tag="MJ749_RS19195"
                     /old_locus_tag="MJ749_19195"
     CDS             8628..9455
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372706.1"
                     /locus_tag="MJ749_RS19195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19195"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_016818617.1"
                     /transl_table=11
                     /translation="MMQTRAKSIVLYAGLLVGIILSMFPFYWLIVMATRTTSDIYRFPP
                     QLWLGSHFLDNITRVLQQIDFAGAFLNTLFVASSITLLVLFFDSLAGFAFAKFDFPGKK
                     VLFVILLATMMVPSQLSLVPSFVMMASFGWVGTFKALIIPGMVNAFGIFWIRQYAEESI
                     PKELLDAGRMDGCSFFRLYWNVALPILRPAFAFLGAFTFIGAWNDYLWPLIVLTDERKF
                     TLQIALSQLNGIYNTDYAMVIAGTLLAVLPLIILFLFISRQFISDLAAGAIKD"
     gene            complement(10001..11533)
                     /locus_tag="MJ749_RS19200"
                     /old_locus_tag="MJ749_19200"
     CDS             complement(10001..11533)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372709.1"
                     /locus_tag="MJ749_RS19200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19200"
                     /product="radical SAM protein"
                     /protein_id="WP_016818616.1"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     2.3e-07, bitscore: 29.1, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 2e-47, bitscore:
                     160.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 5.4e-11, bitscore: 41.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5.9e-06, bitscore: 24.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILDSTVMEFFRNIKKQYGNYSRLFKLFQTKNKSYLYDVGTGKVM
                     ECTEIEYVFLNNLQVYGDIEEVIKTTKVNDDTLTILIDLIHVAQEQHLFQAPPLLSFAL
                     SKDEVLENARSHLEQVTLELTEQCNMACHYCIYHSGNIDFREFGRRHMSWQVAELAIDY
                     TLKNSGKKVAVTFYGGEPLIEFKLLKHCVDYTLKNGADKDLTFSMTTNLTLMTAEIAEY
                     LSTVPNFGVVCSIDGPKEIHDCRRVFKNGEGTYDKAINGLKHLINAYGEKSNSLISLSM
                     VTPRPANDVVMKKIQNFFNSLSWVPKDITKNISYVRHSSDIEKTITEKSSMHCYDNPVG
                     NWTIDLMLNNTSISKNTPFTIDFLHKQFSIIHDRILTETPYPDYCLNGCCSPASRRIYV
                     TVNGDFHLCERIGKSPSVGNVYSGIDESVLIDRYIDDYGKESLSQCSKCWAIRLCSVCY
                     VECYDSDKFNIEKKKIACRRSLDMLEHALISYHTILEHKPHLLEELNHITLV"
     aSDomain        complement(11129..11518)
                     /aSDomain="Other_Sactipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a sactipeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MJ749_RS19200_Other_Sactipeptide_rSAM
                     _RRE.1"
                     /evalue="1.30E-09"
                     /identifier="RREFam021.1"
                     /label="MJ749_RS19200"
                     /locus_tag="MJ749_RS19200"
                     /protein_end="135"
                     /protein_start="5"
                     /score="29.1"
                     /tool="antismash"
                     /translation="TVMEFFRNIKKQYGNYSRLFKLFQTKNKSYLYDVGTGKVMECTEI
                     EYVFLNNLQVYGDIEEVIKTTKVNDDTLTILIDLIHVAQEQHLFQAPPLLSFALSKDEV
                     LENARSHLEQVTLELTEQCNMACHYC"
     gene            complement(11499..13172)
                     /locus_tag="MJ749_RS19205"
                     /old_locus_tag="MJ749_19205"
     CDS             complement(11499..13172)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818615.1"
                     /locus_tag="MJ749_RS19205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19205"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_016818615.1"
                     /transl_table=11
                     /translation="MIVLEYLKKYLSKTRKYVFFYIVVTSVLWIIGIIVPYITGIYIDY
                     LVSKSNISIILYFVLLLGIINIVNILIQYLTALFSTKLNNLLLYEICNDIYQKIFKTKL
                     SVFKDKDNAYLVDQINNDSSTVVDFFSNNISNLVLQVITIIISGIIVLKADVLLCVIIF
                     SLIPFYIFTYVVFRKKLYKANLKYKKEANEYYSKKVEQINKLVFIKKNVLFNEMNERLN
                     KAFNSLFRVATSQVKTNYIFSNLNQFILIICYIFVIGIGGHKVVIGQMSIGQFTIINTY
                     LSMIISSTSYLLSLASSYQETKVSIERLNDVMNSENDIYGSTTLEDLEKISIKQLGVKY
                     SEESVFRDFSYDFFKGGIYGICGHNGSGKTTLLNTLIGLYSDLYTGEIAFNNCSIKDID
                     MLDMRRYRISYVEQNPEFLNLPIKEYLKFGITFSKEIASNQDELITAFGLEEIITKANL
                     ENILINENGSNFSGGEKQKLALIRALSKDSFLTILDEPTSALDSKSVSGLIEILTKQKS
                     RRITIVVSHDQRLLAACDHILNIETQEERDDIGFHSYGVL"
     gene            complement(13419..14066)
                     /locus_tag="MJ749_RS19210"
                     /old_locus_tag="MJ749_19210"
     CDS             complement(13419..14066)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818614.1"
                     /locus_tag="MJ749_RS19210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19210"
                     /product="hypothetical protein"
                     /protein_id="WP_016818614.1"
                     /transl_table=11
                     /translation="MLMLKKMCIVLCGFLLMGMPLGASSNAASNDVKNINLTAINCNVT
                     VTKTSASDFSYEYNKSLYTVTSTLSGSTIYITVKGKGSANGISDRVNILIPDKSYEKIT
                     VESTKAGVSLPELNTNLDITGVDGSSMSVRVPVGYSKAISYDNTKGSGSLTFSKGASDY
                     TVTVKTTASALSVPAGWPLFRPNLTYNYINGAGKAKINITLENSAFSIAAQK"
     gene            complement(14060..15388)
                     /locus_tag="MJ749_RS19215"
                     /old_locus_tag="MJ749_19215"
     CDS             complement(14060..15388)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372712.1"
                     /locus_tag="MJ749_RS19215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19215"
                     /product="radical SAM protein"
                     /protein_id="WP_019688427.1"
                     /sec_met_domain="PTHR43273 (E-value: 6.6e-40, bitscore:
                     135.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2e-14, bitscore: 52.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.4e-10, bitscore: 38.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.4e-16, bitscore:
                     57.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKASQYNFIFNDIIENTDKTVLYNSRTGALAVLEPEYYKQFCEHT
                     NNGLAINNDTYLKNLIECGYIVEDNMNEKAYVKVNLLKNRFESSNLMLTIAPTMACNFR
                     CVYCFEKDQYHNKTMSEETAQSIVNFVKANASKLDTLNVTWYGGEPLIAMKQIVRISED
                     FLEICKENNIQYTASVITNGYLLNKEKVQTLISCGVNDIQVTVDGPKEVHDLRRPLVSG
                     RGTFDVIMNNLKQIKGMIKIFMRINTDQDNWLNLHEIVGFLKENSLLENVIPYLGLVTP
                     TNGKYEGTKCLTDEMYSKFNLKFMSENDIPISYIYPAPKGNYCSADKYNSFVIDPLGHL
                     YKCWSDIGIIEQCVGNINEDTSVKWNTELLGCYLLYDPTEDEKCSDCKYLPVCLGGCPH
                     NRMADFNICEQYRYNLQEYITECTKVLLAGQLTENKKEVSESC"
     misc_feature    complement(15443..15458)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     misc_feature    complement(15883..15898)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.64"
                     /tool="antismash"
     gene            15955..16710
                     /locus_tag="MJ749_RS19220"
                     /old_locus_tag="MJ749_19220"
     CDS             15955..16710
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818612.1"
                     /locus_tag="MJ749_RS19220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19220"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_228552499.1"
                     /transl_table=11
                     /translation="MVYLFQVAVCDDDPAMHKILQHFFMCMSVSESLDFNLQFFLSGED
                     LIKSYSSQERYPFHIILLDIEMRELSGIETAKLIRLFPDREVQIIFLTNYPEYMLESFE
                     VQAFQYLLKPLTYKLFVEKINKLCHYMRSSVSHFLSVKNKTEHLVLRHSEIIAISKGEN
                     NYIHNELCIATDSHNYFISGTLKAVYEQLKYPFVFIHRSIIVNLVHIRKFSATSVIMSN
                     EQEFPVGRSHAKSLREAYARFIISRFQEG"
     gene            17109..17729
                     /locus_tag="MJ749_RS19225"
                     /old_locus_tag="MJ749_19225"
     CDS             17109..17729
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013372715.1"
                     /locus_tag="MJ749_RS19225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19225"
                     /product="ATP-binding protein"
                     /protein_id="WP_230877304.1"
                     /transl_table=11
                     /translation="MQEKRYKETTRSLSDIKRSIHDFKKQLIFVRACLQEQRTEEGVNH
                     INQTLKNIDSPKLHITTGHLVIDALVNHTFSIANKSGIAFFHQIHINPANISIGSHDLC
                     IVLGNVFDNAIEAVMQLPRKKEHSIHLEIFTDNFALWIYVRNSKSNYLNTAFSTKTYNS
                     PSKKHGYGLLNIQQVIKKYGGYLNTTITDSHFQITIMLPCNNS"
     gene            complement(17856..19274)
                     /locus_tag="MJ749_RS19230"
                     /old_locus_tag="MJ749_19230"
     CDS             complement(17856..19274)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005283 - amino acid:sodium symporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1153: Amino acid carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016324662.1"
                     /locus_tag="MJ749_RS19230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19230"
                     /product="sodium:alanine symporter family protein"
                     /protein_id="WP_038978208.1"
                     /transl_table=11
                     /translation="MNLVHVLETIDSWMWGAPLLILVMGTGLWLTIRLKMLQIIRLPLA
                     LKLIGKAPDEGSGDVSSFGALSTALAATVGTGSIVGVATAIKLGGPGSLFWMLVAAFFG
                     MATKYAEGLLSVKYRVKDRNGQFSGGPMYYIENGLGRRFKPLAMLFAFSGILVALFGIG
                     TFPQVKAIVSSTESSFGVPTVVTAIIISVLTAVVTIGGLKSIAKVSTKIVPFMSGLYIV
                     VCLIVLIKFAGELPHAIALVLQGAFSTTSATGGFAGATIMLAMRSGVARGIFANEAGLG
                     SAPIAAAAAKTKWPAEQGLISMTGVFIDTMIICNLTGFTLLVTGIWSGNDDGGLMTQHA
                     FSSAFPAGAELVTISLILFAFTTILGWNYYGERCVEYLLGVKWIKPYRYLFIVLVAGGA
                     FIKLDAIWLLADIFNAMMAFPNLIALLGLSGIVVAETRTYMNSLYPNKNKGILAGANVG
                     AAIQVEEKGQTVNS"
     regulatory      complement(19434..19528)
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    19637..19655
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.42"
                     /tool="antismash"
     misc_feature    complement(19678..19693)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 25.74"
                     /tool="antismash"
     gene            complement(19793..21250)
                     /locus_tag="MJ749_RS19235"
                     /old_locus_tag="MJ749_19235"
     CDS             complement(19793..21250)
                     /EC_number="3.2.1.-"
                     /GO_function="GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010348049.1"
                     /locus_tag="MJ749_RS19235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19235"
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="WP_016818609.1"
                     /transl_table=11
                     /translation="MTKTLKGFPKNFLWGGATAANQLEGAFDVDGKGLSSADMIAYVPK
                     SERKNDHAIEISSERLEDILAGKVNARFPKREGVDFYHHYKEDIALFAEMGFKVFRMSI
                     HWSRIFPNGYDAEPNEAGLQFYDNVFDELRKYGIEPLVTLSHYETPLGLTQKYNGWLGR
                     EVVDHYVKYAETVFTRYKDKVKYWLTFNEINVMTMSPFTGGGVVIDRVENKQQAIYQAL
                     HHQFVASALATKRGHEIIPGAQIGCMLARIESYPHTCNPEDILKAQHENQMNLFFTDVH
                     ARGEYPNYMNRYFEENNIVIQTEPGDAEILKNNTVDFISFSYYMTLTVSAGPEGEKAAG
                     NLIGGVKNPYLQSSDWGWQIDPIGLRVTLNTFYDRYQKPLFIVENGLGAYDKVEEDGSV
                     HDTYRIDYLRQHIAQMKEAIADGVDLIGYTSWGPIDLVSMSTSEMSKRYGFIYVDLDDD
                     GNGTLQRSKKDSFNWYKNVIATNGEEL"
     gene            21462..22433
                     /locus_tag="MJ749_RS19240"
                     /old_locus_tag="MJ749_19240"
     CDS             21462..22433
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007431750.1"
                     /locus_tag="MJ749_RS19240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19240"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_044787396.1"
                     /transl_table=11
                     /translation="MSNLDQIAKLAGFSKATVSRVLNQSPHVSQETRAKILKIMQELDY
                     VPNRNAISLSKGQTLQIGIITSTINEIVLAFLDSFVEIAGQYEFQTIIYTSGEDKKKEL
                     QAFEDLKRKRVDALVIISCVNDTDFLSTYCKYGPIVAWQRMEHTDIRSVAMDQYEGYML
                     ALKHLIQKGYTRIANAFGRPSSINTHSRQRAYEQIMSEHNLPVLPHWNYSSIYNIRDGE
                     QVVRNLLQHREEFPEAILCANDYVAVGILCEARRQLLRVPEDLAIVGFDNTELAHTMGI
                     TTVQNPIMAQAQNAFFMLSPQLIGRQMELHSLEYSLIERTTT"
     gene            22667..23515
                     /locus_tag="MJ749_RS19245"
                     /old_locus_tag="MJ749_19245"
     CDS             22667..23515
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818607.1"
                     /locus_tag="MJ749_RS19245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_19245"
                     /product="PRD domain-containing protein"
                     /protein_id="WP_016818607.1"
                     /transl_table=11
                     /translation="MIIEKVLNNNVLLTKNDKGKEVIVMGRGISFKKVAGDQVDDHKID
                     KIFMLNENEFTARLTELLNDIPVSHLEVVNEIVTHAAEVLDTELSDNIYLTLTDHIHFA
                     IQREEKGLALKNAMLYEIKRFYKKEFAVGLDALQKIENTLGVKLGEDEAGFIALHMVNA
                     RIDGNEMKATLKMTEIVQHILNIITYHYGIVLDESSFSYSRFLTHLQYFAMRVIRKEVI
                     HSGEEFLYNQVKQTYTEAFACAQKINEYLEKTYDQYLSKDEYVYLTIHIHRVTERNNIS
                     G"
     misc_feature    complement(23553..23571)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.98"
                     /tool="antismash"
ORIGIN
        1 ggccatacat ccttaccgcc gaaaccaatc ggttccacgc cgttatcctt gagcaccttc
       61 ataacattca ccagttcgtc ccatgtcgtg ggcacagcaa gattatattt ttcaaaaatc
      121 tctttgttgt aaaacagacc tgtcagtgct accttaccca tgtttacacc gtataccttg
      181 tcgttatagg tcatggcatt tttgacatct gtaggattat agtttttgat aaaagcttga
      241 tctgacagat ctgcaatgag tcctccctcg atccactgct tccacatcgg atcagcagct
      301 cccttagacc attcttgcgg tgcgcctacg aagctgaatt tcagaggaat aatatctgca
      361 tcaccggttg aacccgcatt catacgcgtt tgcatcagtt gatcataagt ggaatcagca
      421 ggaaccgtcg tatactccac ctgaacatca ggatacttct cttcaaactt tttattaaat
      481 tcctttatat agttattaat attctcctgc tgccaatgaa taatttttaa cgtgaccttt
      541 ttattcccgt tctgaccagc ttcgttacct ttaccgcaag cggctaatac cacgattaaa
      601 gcggttacaa caagtaaaga aaaacacttt ttcagcattg caaaattccc cctgtaatct
      661 tagaataaat gcactcactc ttacgaaagc ggtttagtta attacagcta ctattatgta
      721 tcgaatagcc tgtatttgta aatagcaatt tgtaaattat caaaaaatca ttaactatcg
      781 ttaaatcgaa cttcattatc cataatatat taggatttat cctttaatag cacggttgac
      841 tctcttctat gaggtagcat agaatacgag taatcattaa ttttagaatg caaggtcaaa
      901 tgaactaaat cagtttagtt gcggaggatt ccatgaatat aaaaacaata gctagcatgg
      961 caggcgtttc agtagcaacg gtttcgaaga tcataaacaa ttacactgat atcagtgagg
     1021 aaacccggca gcgagtactc aaaattatgg aggagacagg ctatagacct tcttcctcgg
     1081 ctaaaacgct tgctaccaaa aaatctaatc tggtaggcgt tatattcgct ggcaagctga
     1141 atgtcgattt tagccatcct ttttttgtag acatcattaa tgttttcaaa aagcagattg
     1201 gcttgctcgg ttacgacctg ctgttttttt cgaatgagaa atttctggat aatggagagg
     1261 actatttggc tcgctcaaaa tatttctcag tggacgggtg cattattatt gccggagacg
     1321 aagtggagaa gagtgttttt gatctcgatg ccagccctat cccctgcatc ggtgtcgata
     1381 tcgaactaac cggagccagt tcctgctaca tcatgtccga caatcaaaag atttcaatga
     1441 aggttgttga gcacttttac atgaatggat accgcgaaat gggttttata ggcatagaac
     1501 gcccctcctt ggttattaaa gagagagaag aagcttttat ctcatcacta aagcggttta
     1561 gccttgatgt cagaccggaa tggatcgtgt atggcaagga ctatgcagca gaggatggat
     1621 accagatcgc aaaggcgtgg atagagcaag aaaatttacc aagagctatt tttgcggcta
     1681 ccgacctgct tgcctttggt gccattcgtg ctttcaagga gagcggcttg agggtacccg
     1741 aggatattgc cgtagtagga tgtgatgata ttgaagcctg tcgttatacc gatcctccac
     1801 tgacgacggt aaaacaagac aagcaaaaaa taggtcgtct ggctgctatg gtgctgtttg
     1861 acctgatgaa taaacaaatg gatacgaaat gtattaaagt ggagcccgaa ctcgtcattc
     1921 gcacctcctg cggagcccgg caacattgga accctacaag ggttgaggga tagcacatac
     1981 ctaaaaaagg tgactcctgt cgaattcaga agtcaccttt ttgcagttat ataacaagag
     2041 ccctttcgtt taagccatta tttgtaggcc atcgtcgcat tcacagcctt tttccagcct
     2101 tcatacaggc tatcacgtgt tgcttcatcc atcgtagggg taaaagaagt ttccactctc
     2161 actcgcttac gaagttcatc tgtactcttc cagtatccta tcgccaatcc tgccagacat
     2221 gcggcaccca gcgccgttgt ctcatggata actggccgtt ccaccgttgc atccagaata
     2281 tcgctctgga attgcatcag gaaattgttc aacacggctc ccccatctac ccgcaacgtc
     2341 ttcaccgcaa tacctgagtc aatctccatg gctgtaagca catccttggt ctgataagcg
     2401 agggactcca aggtggcacg gataaaatgc tccttcgtgg tcccacgtgt cagaccaaac
     2461 atcgctccac gcacctcgct atcccagtag gggctgccca gcccgacaaa agcgggtaca
     2521 agatatactc cttctgtgga ggaaacacgg gccgcgtaag gctcactgtc ctttgcttca
     2581 cggaacatgc gcaacccatc tcgcagccac tggatcgcag agcccgcaac aaacacactc
     2641 ccttcaagtg cgtattgcac tttgccttcc tccagccccc aagcgatggt cgtgatcaga
     2701 ccgtgcttgg attcaaccgg ctgatctccc gtattcatca acatgaagca acctgtaccg
     2761 taagtgtttt tgatcattcc tttttcataa caagcctgac cgaacaaggc tgcctgctgg
     2821 tcacccgctg caccggcgat cggtacattc tgaccaaaaa aatgataatc cacggtgtgc
     2881 gcatatacct cggaagaagg ccttacctca ggcaacatga ttttcggaac tcccagaata
     2941 tccagtagct cttcatccca ctttagctca taaatattgt acatcagcgt tctggccgca
     3001 ttggagtagt ctgttacatg ggcctttccg ccggatagtt tccagattag ccacgagtca
     3061 atcgtaccaa ataataagtc acctcgttcc gctctttccc gcgctccttc tacatggtcc
     3121 agtatccact ttactttagt gcctgaaaaa tacggatcga tcaatagccc tgttttgctg
     3181 tgaaacaact cctcatgccc ttgccgcttc agttcttcgc aaatatccga ggtttggcgt
     3241 gattgccata cgagtacgtt atacacgggt aatccggtat ttttgtccca cacggccacc
     3301 gattctcgct gattggtaat gccgatggca gcaatttgtt ttgcttttac accggattcg
     3361 gaaagacagg aggcaataac gcccagaata gaactccaga tttcattcgc attctgctct
     3421 acccagccgg ggtgaggaaa atattgcgga aattcccgct gggccgagta caccacatct
     3481 ccttcgctat tgaacaaaat cgctcttgaa cttgtcgttc cctggtctag tgacaaaata
     3541 tattttccca tgttcatctc tccctgtgta aatccatcgt ttttacgctg taagcttgtg
     3601 atccatttta tgatttttat aaatacgact aataccgaag gtaatcaaga gtacaaccac
     3661 gataacccct aataaaatcc agaaggccgg agtcatactc cccttaaaaa cggcctgata
     3721 aaacggccct gcgaaagatc cccccaatag cggtcctaca atgggcaccc atgcatattt
     3781 ccagttggat gctcccttac cgggtatcgg tagtaaataa tgcatcagac gcggcccaaa
     3841 atccctcgct ggattgatgg catagcccgt tgtgcctcca agggataaac cgatactgac
     3901 aaccaaaaaa ccaacaatta gcggtttaag gccgtctgta aacgaattgg caccaaacga
     3961 cagtaaagca agaacaaaga taaaagtacc tatcatttca ctaagcacgt taccaaacgg
     4021 atgatcaata gctggtcctg tcgcaaatac actgagtttg gctgctgtgt cctccgtctc
     4081 tttccagtgg ggccaataat gcaaaatgac gatcactgca cccgccatgg ctccaagaac
     4141 ctgagccaca atataaccgg gaacatcctg ccatggaaaa ctaccctgaa atgccaacgc
     4201 gagtgtaact gcgggattca aatgcgctcc gctgatttgg cccaccgcat acaccccaat
     4261 agctaccgcg agcccccacc ccaatccgac cacaatccag ccggaagcgt gggcaaaaga
     4321 ctttttcagg gacacccctg cgcacactcc gccacctagg gcaataagaa tcattgtccc
     4381 tatgaattcg gctgcgtatg gcgacataca accaacctcc tcaatagatc atccgatttt
     4441 gatcgttttc atcgcgcaaa aaaaagaaaa gccatcacaa accaaccctg tgctgtaaca
     4501 tgggatgtct gcgtggctct cttgtctccg tcacgattat taacttaaat ttgatattat
     4561 ataagcatgt aagcgatgtc aactgcggat ttacgtcttc tgatatccta aaataatcgt
     4621 tgaccatgtt agattgcccg atttatgatg taaaaaaatg gctgaatgta aggaggattt
     4681 caggatgaat acgacactcc caaacttgat gatgaaggga agaatgttat gctgaaattt
     4741 ctgcaaaaaa tcggcaagtc attaatgctt ccagtagcta cattacccgc cgcagggatt
     4801 ttgcaagggc tggctctcat taattatgaa acggatattc cgcttggccc tggagttggt
     4861 ggatttctga atcattatgt cactcctttt ctgaatgaag gggcgggtgc tatctttggc
     4921 aatctggcgc tcattttctc catcggtgtt gctattggtc tggcaggcga cgcggtagcc
     4981 gcactttcgg cagtcattgc ctatttggtg ctgacccgta ttttggcggc cgtaccgggt
     5041 atatttgcgt atattccaga cgacgtcaag ctggacatgg gcgtattggg cggtattttt
     5101 atcggcggat ggtctgctta tctgttcaaa aaatatcata atattcaact tccagattgg
     5161 ctcggctttt tttcgggcaa acgttttgtc cccatgatta cagccttcac gaccatgatt
     5221 ttagccattc tgctcggcat gatctggagt ccgatacaag atggcattgc agccttcggc
     5281 aactggattg ttggctttgg tggaatcggg tcaatggtgt tcatgattgc caatcgactg
     5341 ctgatcccgc tcggtttgca tcatgtgctg aactcgatcg catggtttca aattggggac
     5401 tataccaacg ctgcaggtga agttgttcat ggtgacctga cacgtttttt cgcaggcgat
     5461 acatcggcgg gtatgttcat gtccggcttc ttccccatta tgatgttcgc tctgccagcg
     5521 gcggctcttg cattcatcca tacggccaag ccggaaaaac gtaaagctgt cgcttccatc
     5581 tttatcggct ctgcactagc gtcgttcctg accggtatta ctgagcccct cgaattttct
     5641 tttatgttca ttgcacctct gctttacggc gttcatgctc tgctaacagg tctgagtggc
     5701 ctagtcgtat acctactgga tgtcaaactc ggcttttcct tttcagcagg actcattgac
     5761 tatctggtca atatgaagct ctccactcat ccattgcgaa tgatcccgat cgggcttgtc
     5821 ttcgccttca tttattattt tctgttccgc ttcatcatcc tcaaattcaa cctaaagact
     5881 cccgggcgcg aagacgatgt agatgacacc cttctatttg aggctaacaa atccataccc
     5941 gttggaaaaa caagcgcctc atccggcacc cagtccagtc aggcaggcca ggtcctaacc
     6001 tatctcggcg gttcagacaa tatccaaagc attgatgcct gcatcacgcg gttgcgtctt
     6061 gtcgtcaagg acgacaaagc ggttaacgat caagctctta agcagctcgg agcgtcagga
     6121 attatcaggc ttgggaacgg taccctacag gttattttcg gtactcgatc cgaagctctg
     6181 aaagatgaga tacaacgatt gatgtcatga agctaatccc ctgccttaag cacgtgcgat
     6241 cttcctataa cagacgcacg tgcttttttt tatggataaa cgtttcaaat tttttgtttt
     6301 tggttaaggc aatgcacata aatgggtaac agcttcatat gatggagcta aaccatttac
     6361 aacttgttca gcaggcagat tattcagaca gcaaggaggg aaatgatgtg aagacagtac
     6421 aatggcaatg gctggtatta tgtcttgctt ttctcactat gattagtggt tgtagtgggt
     6481 ccctatcctc taaaggtcaa tcatctgaag ctaatttgtc aaacagtaaa aagataacgc
     6541 ttacattgtg gtactggaat cgttctattg acgatgaatt gctcgtccag gcagaaaaac
     6601 agtttcccaa cattgaatta aaaactcaaa aaataggcgg tgactttaaa gccaagctga
     6661 agacaacgct cgcagctcgt tccggtgaac cagacatcgt agctctgaac gactggatgg
     6721 tggagctatt cccgagtgcg gatcgttttt atgatctaaa ggaactcgga gcagaccgac
     6781 tgaaggatca atatttggaa tggaaatgga atcagggcat cactcctgat ggtaaaatga
     6841 ttgcatttcc catggatact gggcctaccg ccctcttcta tcgaagcgac ctgtttgaac
     6901 aggcaggctt gccaagtgat cctgaacagg tcagcgcctc gatccgcaca tgggatgatt
     6961 atatggcagc cggagaacaa cttcggcaga aattcggaag ccattcattt ttggccgata
     7021 atattgtaaa cgtttacaat caggtactcg ctcaacatac gaacctgtac ttcaagccgg
     7081 acggaagtta tatcggcaat caatctcctg acatccgcct gggctggaaa accgctgtgg
     7141 atttccacag gaagcatctg ctcgccaatg cagatggctg gactcctgaa tggaatgctt
     7201 cggtcaataa cggcaaaatc gcctcgttcg taggggcaat ctggatgaag caagttctca
     7261 cagaagccgc accggataca gcgggcaaat ggagagtcgc ccgtgctcct ggaggagacg
     7321 gaaatctggg agggtctttc atctctatcc tcaaatctag ccaacacccc aaagaagcct
     7381 ttgaagttct gacctggctg caaagcccgg aacaccaact ggaagcctac cataaaatcg
     7441 gcctgttccc atccactccc ggcgtctatg acgatccagt catggagaca cccgagcctt
     7501 tctttggtgg tcaggccact ggcctcattt ttgccgcctc cgcacgtcag gtgaaaaata
     7561 gctatttcgg cgagcgctat cctgtcatcc acggcattgt aacccgtcgt cttgccaatg
     7621 tggccaaaca aaatgccgat cccgactcat tatggacgga aacaatgcaa cgaattgaac
     7681 gggaattaca gcgttaaaaa acaaaacttc aaaaaaggcg tgtggacaat atgctgagag
     7741 aaatctggaa gcaccgggcc gtttatgctg cgatctcgcc attttatttg ctgtttggca
     7801 tctttggctt gtttccgatt ggcttttcat tgtacctggc gtttcacaaa tgggacggga
     7861 tcggagacat gacctacaac ggctggggca actttcgtta ccttgtgaca gacaacgaat
     7921 tttggcaggc tgtaggtaat acgtttgtga tctgggtgta cgccacgatt ccaatgctat
     7981 ttctagcact cattgttgcc tttctgcttt atgccccttt tgtgaaaatg cgcaccttat
     8041 ggcgagttgg attcttcctg cccaatgtga catctattgt tgctgttgcc atcatctttg
     8101 gcgccttatt tgccaacaat tttggatttc tcaactacct tttgcagctc ttggggctac
     8161 ctatgatcca atggctgaat gtgccatggg gtatccaaat cgccatttct tccatggtcg
     8221 tctggagatg gatgggttac aacgccatta tctatctggc tgggctccag agtatcccac
     8281 atgtgctgta tgaggccgcc aaaatagacg gggcaaccgg agcgcaagct tttttccgca
     8341 tcaccattcc gatgctgcgc ccagtcattc tgtttacggt cattacgtcc accatcggtg
     8401 ggatgcagct gttcaccgag ccacaggtcc tggtcggtaa tgacggcggt gccggggcaa
     8461 gtggcatgac catcgtttta tacctgtacc gcgagtcgtt cattaacaac tattttggat
     8521 atggcgctgc tgtcggatgg ggcatgtttc tcatcattgc tctattctcc atcatcaatt
     8581 ggaaactcgt tcaaggtaaa aaataacgat ggaaggagct ttaccacatg atgcagacac
     8641 gtgcaaaatc cattgtttta tatgctgggc tgttggtagg tatcatcctg tcgatgtttc
     8701 cattttactg gctaatcgtc atggcaaccc gtacaacctc agacatctat cgttttccgc
     8761 cacaattgtg gttgggcagc cacttcctgg ataacatcac gagagtattg cagcagattg
     8821 attttgccgg cgcctttttg aatacccttt ttgtagccag ttcgattacc ctattggtgc
     8881 tgttttttga ttcactggcc ggttttgcat tcgcaaagtt tgattttccg ggcaaaaagg
     8941 tgctattcgt cattctgcta gctacaatga tggtcccttc acaactttcg ctcgtcccct
     9001 cctttgtcat gatggcttcc tttggatggg taggtacgtt caaagcgctc atcatcccgg
     9061 gtatggtaaa tgccttcggg attttctgga ttcgtcagta tgcagaagaa tctattccca
     9121 aggagctcct ggatgcgggg cgtatggacg ggtgcagctt ttttcggctg tactggaatg
     9181 tagcactgcc gattttacgc cctgcgttcg cttttctcgg cgcatttacc tttataggag
     9241 cttggaatga ttacttatgg ccattaatcg ttttaacgga tgagcgcaaa ttcaccctcc
     9301 agattgcatt gtcgcagttg aacgggattt acaatacgga ttatgcgatg gtcattgctg
     9361 gcaccctgct ggctgtactt cctcttatta ttttgtttct tttcatcagc cgccaattta
     9421 tttccgatct tgccgctgga gcgatcaaag attagcttcg cttgattccc cttttacttg
     9481 ctctaaagcg tcttcgaaac tggacttaag ctctggagag gaattgcaca actatgagct
     9541 ccgtgcgatt ttattaattg gaacgactgc tctaaacgga acactcaaat agactacttc
     9601 gaggctgagt ttacacacga ttgaacatgt actgtctacc tgttatccat atttccttgt
     9661 aaattagcct ccatagttat ctaacgatta ataaaaatcg cttccactca tttaacagag
     9721 tagaagcgat ttttcaaaaa ttaaataaac gtttctctaa taggtcaact taaagccata
     9781 tcatagtttg cactactatt catttgccta tcagagcgac atttacatgc acaattcgag
     9841 ccatgtccga agtcatgaag tatattatta gcaccggaag aacaaataca agataaagga
     9901 acaattccaa gggtatttgc cattaaaggc ttccttccaa atggatttac aattctcaat
     9961 ttataatcct ccttcgactc gttttgataa tagattggaa ttacaccaat gtaatatggt
    10021 ttaattcctc taataaatgt ggtttgtgtt ccaagatagt atgatagctt attaatgcat
    10081 gttccagcat atctaaagaa cgcctacaag ctattttctt tttttcgata ttaaacttat
    10141 cactatcgta acattcgacg taacaaaccg aacaaaggcg tatagcccaa catttggagc
    10201 actgggacaa actctcctta ccatagtcgt ctatataacg atcgattaat acagattcgt
    10261 ctataccact ataaacgttt ccaactgaag gtgattttcc aatgcgctcg cataaatgaa
    10321 agtctccatt taccgttaca taaattcttc ttgaggcagg tgaacagcag ccgtttaagc
    10381 aatagtccgg gtaaggagtt tcagttaaaa tcctatcatg tattattgag aattgtttgt
    10441 gtaaaaaatc gattgtaaag ggagtatttt ttgatataga agtattattt aacattagat
    10501 caattgtcca gttccctaca gggttatcat aacaatgcat agagcttttt tcagtaatcg
    10561 ttttttctat gtcagacgag tgtctcacat aagaaatatt tttagtaata tccttaggta
    10621 cccacgaaag agaattgaag aaattttgaa tttttttcat aactacatca ttagctggtc
    10681 taggtgttac catgcttagc gatataagag aattactctt ttctccataa gcattaatta
    10741 gatgtttaag accattaatt gccttgtcat acgtgccctc accattttta aataccctcc
    10801 tacaatcatg tatttccttt ggaccgtcaa tactacaaac tactccaaag ttaggaactg
    10861 tagatagata ttctgcgatt tcagcagtca ttaaggttaa gtttgttgtc attgaaaatg
    10921 ttaaatcttt atcagcacca ttttttaaag tatagtctac acaatgcttt aataatttaa
    10981 attctattaa tggctccccg ccataaaaag ttaccgccac ttttttacct gagtttttca
    11041 gagtataatc gattgctaac tctgctactt gccaggacat gtgcctgcgt ccaaattccc
    11101 tgaagtctat gttccctgaa tgatatatac aatagtggca tgccatatta cattgttcgg
    11161 tcaactccag agtaacctgt tctagatgac ttcttgcatt ttctaaaacc tcatcttttg
    11221 atagtgcaaa ggataaaaga ggaggtgctt ggaataaatg ctgttcctgc gcaacatgta
    11281 ttaagtcaat tagaatagtc aatgtatcat cattaacttt ggtagttttt attacctctt
    11341 cgatatctcc gtacacttgt aagttattta gaaatacata ctctatttca gtgcattcca
    11401 taactttgcc tgtgcccaca tcatacaaat aggatttatt ctttgtctga aacaacttaa
    11461 acaatcgtga gtaattccca tactgttttt tgatgtttct aaagaactcc ataactgtgg
    11521 aatccaatat catcacgttc ctcttgggtt tcaatattca aaatatggtc acatgctgct
    11581 aatagtctct ggtcatgtga tactacaatt gttatccttc ttgacttttg cttggtcaat
    11641 atttctataa gtccacttac actctttgaa tctaaggctg atgtgggctc atcaagaatc
    11701 gttaagaaag aatctttact taatgcacga atcaaagcta atttttgctt ttcaccacca
    11761 gaaaagttgc ttccattttc atttattagt atattttcaa ggttagcttt tgttattatc
    11821 tcttcaagcc caaaagctgt tataagctca tcttgattac tggcaatctc ttttgaaaaa
    11881 gtaattccaa atttcaaata ttcctttatt ggtagattta aaaactccgg attctgttct
    11941 acataagaaa ttctataacg cctcatatca agcatatcta tatctttgat ggagcaatta
    12001 ttaaaagcta tttctcctgt gtaaagatca ctataaagac ctatcagagt attaagtaat
    12061 gttgttttgc ctgaaccatt gtgaccacaa atcccgtaaa ttcccccctt aaaaaaatca
    12121 taagaaaagt ctctaaatac gctttcctcg gaatatttaa cacctaattg tttaatactt
    12181 attttctcta aatcttcaag tgttgtacta ccataaatat cattttcaga gttcataacg
    12241 tcatttagcc gttctatcga tactttcgtc tcttggtatg aacttgctaa gcttaataaa
    12301 tatgaagttg acgagatgat cattgaaagg tacgtgttaa ttatggtgaa ctgccctata
    12361 ctcatttggc caattacaac tttatgacct ccaattccga ttacaaatat atagcagatg
    12421 atcaatataa attgatttag attggagaaa atataattag tttttacttg tgaagtcgca
    12481 actctaaata atgaattaaa tgctttattt agccgctcat tcatttcatt aaagagtaca
    12541 ttcttcttta taaaaaccaa tttgttaatt tgttcgactt ttttagagta gtattcattt
    12601 gcttcttttt tgtatttcag atttgcttta tacaattttt ttctaaaaac cacatatgta
    12661 aatatataaa aaggaataag cgagaaaatt ataacgcata gtagtacatc agcttttaaa
    12721 acaataatac cactgataat tattgtgatt acttgcaata ctaagttgga aatattattt
    12781 gaaaaaaagt caactactgt ggatgaatca ttattaattt ggtcaactaa gtatgcatta
    12841 tccttatctt tgaagaccga cagtttagtt ttgaatattt tttgatagat atcattgcag
    12901 atttcgtata ataataaatt attcaatttc gtagagaaaa gggcagttaa atattgtatg
    12961 agaatgttta ctatatttat aatccccagt aacagtacaa aatataaaat gatacttata
    13021 ttactttttg atactaaata atcaatatat atgcctgtga tgtaaggaac aataattcct
    13081 ataatccaca atactgaagt aacaacaatg taaaaaaata catacttgcg cgtttttgaa
    13141 aggtattttt tcaagtattc taggactatc atattcatca cctatgtttc atattaggta
    13201 aatcttagcg agatgctaaa aacagcatct cgctaagtaa tgttacttct cttatgctac
    13261 atcttgtagg aacaagaaag agtacagcca cttgaaccgt ggaaaggaca atgtgcactt
    13321 acttgtacag cactttttac caatacgtcc atggtttttc cctccttaaa atttaattta
    13381 tataaataac atacagttta aaaactatat gctacttatc acttttgagc tgcaatagaa
    13441 aatgcactgt tttcaagcgt gatatttatc tttgctttac ctgcaccatt tatatagtta
    13501 tatgttaagt ttggtctaaa caatggccat cccgcaggaa cacttaatgc acttgcagtc
    13561 gtcttaactg taactgtgta atccgaagct cctttactaa aagttaagga acctgaacct
    13621 tttgtattgt cataactaat ggcttttgag tatcctacag gcacccgaac tgacattgag
    13681 gaaccatcta cacctgtgat atcaagatta gtatttagct ctggaagtga aactccagcc
    13741 tttgtacttt ctaccgttat tttttcataa cttttatcag gaattaaaat attaactctg
    13801 tcggaaatgc cgttagctga gcctttcccc tttactgtga tgtaaattgt agatccactt
    13861 aatgtagaag tgacagtata caaggatttg ttatactcat aactaaaatc acttgctgaa
    13921 gtttttgtaa cggtgacatt acaatttata gccgttagat tgatattctt aacatcattt
    13981 gaagctgcat tacttgaagc acctaatggc atccccataa gtaagaaacc acataaaaca
    14041 atacacattt tttttagcat taacatgatt cagaaacctc cttcttattt tccgttaatt
    14101 gtccagccag taatactttc gtgcactcgg taatatactc ctgcaaatta taacgatatt
    14161 gctcacatat gttaaagtct gccattctat tgtgaggaca tcctcctaaa cacacaggta
    14221 agtacttaca gtctgaacat ttttcatctt cagtaggatc atataataaa taacaaccaa
    14281 gaagctcagt attccatttc actgatgtat cttcatttat atttccaaca cactgctcaa
    14341 taattccaat atcgctccaa catttatata aatgaccaag aggatcaata acgaaactat
    14401 tatatttgtc cgcagaacaa taattacctt taggtgcagg ataaatataa ctaattggga
    14461 tatcattttc cgacataaat tttaaattaa attttgaata catctcgtct gtcaagcact
    14521 tagttccctc atactttcca ttcgtcggcg taactaatcc tagataaggt attacatttt
    14581 ccaataaaga attttccttt aagaatccta cgatttcatg taaattcaac cagttgtctt
    14641 ggtcagtatt tattctcata aatatcttaa tcatcccttt aatttgcttg aggttattca
    14701 ttatgacatc aaatgtccct cttccactta ctaaagggcg tctaagatca tgtacttctt
    14761 taggaccgtc aacagtgact tgaatatcat ttactccaca tgatattaac gtttgaactt
    14821 tttctttatt taaaagatag ccgtttgtaa tgacactggc cgtatattgt atattgtttt
    14881 ctttacatat ttccaaaaaa tcttccgata tcctaactat ctgcttcatt gcaatcaagg
    14941 gttcaccgcc ataccatgta acattaagag tgtcaagttt actagcattt gctttaacaa
    15001 aattgactat actttgagct gtttcttcac tcatagtttt gttatgatat tggtctttct
    15061 caaaacagta tacacatcga aaattgcagg ccattgtagg ggcaattgtt agcattaaat
    15121 tagaagattc aaaccgattt tttaagaggt ttacctttac atatgctttt tcattcatat
    15181 tatcttctac gatatagcca cattcgataa gatttttaag ataagtatca ttatttattg
    15241 ccaatccatt gtttgtatgt tcacaaaact gtttatagta ctccggttca agaactgcca
    15301 atgcacctgt tcgagaatta taaagtaccg ttttatcggt attttcaata atgtcattaa
    15361 aaataaagtt atattgcgaa gctttcattt tagccctcct tagaatggat gcggtcccta
    15421 tgtaattatg aatcgattaa ctagtgacaa aattcacata agttttaaaa ataagatgta
    15481 cgctcattct gagttgtaat agcattctcg cagtgcacac tagccaccaa gaatagatgt
    15541 ccatcatccg aaaccggact gaatttaaaa gccatcctac acctttatag tttattcata
    15601 tactttattc tctctggaca atatctatac tagatagctt ttccttctcg gcttttaatg
    15661 tagcataagg caaaaagaaa aaataagctt gtatcctgaa atgcaaaaaa gtccatctca
    15721 acgaccaaat atgtcagctt catgtgagat taatattttt gttacctatt ctaagtaata
    15781 aagaagaacg tatccattcc ctcgcctggg ctacgtcctc tccacagtat aagtatgcat
    15841 ttgaactttt actaacaaaa attccataac ctgatggtaa ttgttttcat atgtaaaaca
    15901 tcacttcgaa tagacttttt ttacaatata ctggatttat ataacatatt tgaggtggtc
    15961 tatttgtttc aagttgctgt ttgtgacgat gatcccgcaa tgcataaaat tttacaacac
    16021 tttttcatgt gtatgtcagt aagtgaatcc ttagatttta atctacaatt ctttttatct
    16081 ggggaagatc taatcaaatc ttacagttca caagagcgat acccctttca tattatcttg
    16141 ttagatattg aaatgaggga attatcggga attgaaactg caaaacttat tcgccttttt
    16201 cctgaccgag aagttcaaat catatttcta actaactatc cagaatacat gctagaaagt
    16261 tttgaagtac aagcatttca atatttactt aaacccctta cttataaact ctttgtagaa
    16321 aagataaata aactatgtca ttatatgcgt tcttcagtat cccactttct gtctgtgaaa
    16381 aataaaactg agcatcttgt attgagacac tctgaaatca tagccatctc aaaaggtgaa
    16441 aacaattaca tccataatga actttgtatt gcaacggatt cacacaacta ttttatttcc
    16501 ggaacgttga aagcggttta tgaacaatta aaatatccgt ttgtgtttat acataggtca
    16561 ataattgtga atttagttca tatacgtaag ttttcagcta cttctgttat tatgtcaaac
    16621 gaacaagaat tccctgtagg tcgttctcac gctaaatcgc ttcgtgaggc gtatgctcgt
    16681 tttataattt ctcgttttca ggaagggtga gttttttgaa tcattgcgtt tacattaatg
    16741 tcacctcgtt ttctaattac tctttatttt tatttagcac aacaaagcaa agtgattttt
    16801 ccaatccaat agttaacctt tttttacttt tcgcctcttt acacttcata cttattacag
    16861 tactagtagt tcattatttt aaaaaaggaa gaaaatacaa gatagggatt gtgtattatt
    16921 ttgtaatatt aataggaaca tcgtttaact tgctcataca ttacggttta ttttctttta
    16981 tgaaacataa tttattcttt ataatgtcaa tcatcagtat tcttggaatg aacgtgatta
    17041 ttgtctttct aacggacaag ttgatagaaa agtcaaacct ctcatgcttt tttcaaaagc
    17101 aaatgctgat gcaagaaaaa cgttataaag aaacaactcg atctcttagt gatatcaaac
    17161 gaagtattca tgatttcaaa aaacagttaa tatttgtccg tgcttgttta caagaacaga
    17221 ggacggaaga gggtgttaat cacatcaacc aaactctaaa aaatatagac tcaccaaaac
    17281 ttcatataac aacaggacat ctcgttattg atgctttggt aaatcatact ttcagcatcg
    17341 ctaataaaag tgggatagct ttcttccatc aaatccatat taacccggca aatattagta
    17401 ttggaagtca tgatctatgt attgtcttag gtaatgtttt cgataatgct attgaagctg
    17461 taatgcagct tcctagaaag aaagagcatt caattcattt ggaaattttc accgataatt
    17521 ttgccctatg gatttatgtt cgcaattcaa aaagtaatta tctcaataca gcattctcaa
    17581 ccaaaacata caattcccct tcaaaaaaac acgggtatgg attacttaac atccagcaag
    17641 tgataaagaa atatggtggt tatttaaata caactattac ggattcgcat tttcaaatta
    17701 cgattatgct cccatgtaat aactcttagg tttgtaaacg ttatggatta agagatattc
    17761 agaataaata aaatgtcggt aatcaccagt cttataacct aaaaaaaagg agtaccctca
    17821 agcctgtgat ggctgaggat actccctttt agtatttatg aatttaccgt ttgtcccttt
    17881 tcttctactt ggatagccgc ccctacattg gcaccagcaa gaataccctt gttcttatta
    17941 ggatacaaag aattcatata agtccgggtt tctgcaacaa caattcccga caagccgagc
    18001 agtgcaatca ggttcggaaa agccatcatg gcgttaaaaa tatctgccag cagccagatg
    18061 gcatcgagct tgatgaacgc gcctccggca accagtacga tgaacagata acggtatggt
    18121 ttaatccact tgaccccaag caaatattca acacagcgtt ccccgtagta gttccagcca
    18181 agtatcgttg tgaacgcaaa taaaataagg ctaatcgtca cgagctctgc tccagccgga
    18241 aaggcactgg aaaacgcatg ctgagtcatc agacctccat catcatttcc actccatatt
    18301 cccgtaacca gcaatgtaaa tcctgtcaaa ttacaaataa tcatcgtatc gataaaaacg
    18361 cccgtcatgg atattagccc ttgttctgcg ggccatttcg tcttagctgc tgctgctgcg
    18421 attggcgcac ttcccaaacc agcttcattt gcaaagatcc ctctggcaac tccgcttcgc
    18481 atcgccagca taatcgtggc tccggcaaat ccacccgtcg cagatgttgt cgagaaagcc
    18541 ccttgtaata ctagtgcgat cgcatgagga agctctcctg caaacttaat aagtacgatt
    18601 aaacaaacca cgatatagag ccccgacatg aatggaacaa tctttgtgga taccttggcg
    18661 atacttttga gtcctccaat cgtaacaaca gccgtcaaca cggaaataat gattgctgta
    18721 actactgttg gcacgccaaa gctactttcc gtagaagaaa cgatagcctt tacttgcgga
    18781 aaagtaccga ttccaaatag tgctacaaga ataccagaaa aggcaaacaa catcgccagc
    18841 ggcttgaaac ggcggccaag cccattttca atataataca tcggtccacc cgaaaattgt
    18901 ccgttccggt ctttaacacg gtatttaacg gataatagcc cttccgcata tttggttgcc
    18961 atcccgaaaa aagctgcaac cagcatccag aataatgaac cgggcccacc cagtttgatc
    19021 gctgttgcga caccgacgat acttcccgta cctacagtag ctgcaagtgc cgtactcaat
    19081 gctccaaagc tactgacatc cccgctgcct tcgtccggcg ctttaccaat tagcttgagc
    19141 gctaagggca atcgaataat ctgaagcatc ttcagacgga tcgttagcca caacccagtg
    19201 cccatgacga gaattagaag cggcgctccc cacatccaac tgtcaatcgt ttctaacaca
    19261 tgtaccaaat tcatttcaac ccgctccttc agcatagtag aaaacaaaaa agagtcaaat
    19321 ctgttgattc gactcctgga gaggttaaag gcacgaaaaa atacaaccat cttgtgcagg
    19381 atttcacctc taaaagctta taaaaaagcc tagggctatc cctgtcacag gttattcgcg
    19441 tctctgtcct tttgcctgag agtttaagca gatgtgatct gcggtgcacc ttcggcgccc
    19501 aattaagggt ctctccagag ttctgtccgt ttacggtccc tgctcgttgc tgtaaatcag
    19561 cctaagcacc tgagagtttt gccccttcgg ttggaacttt cattccatct cccgcaaaca
    19621 tcaaccagac atatgaaatt tttattcatt atacagaaaa atttcagctt attacaagtg
    19681 aaaaatttgt gaagccctct gaaagaatca atagagtgtc tatacaaaaa gcgggtacaa
    19741 cagattgcat cctgaggatt ttctctgctg tacccgccaa aacgttatgg aattataatt
    19801 cttcaccgtt ggttgctatc acatttttat accagttaaa tgagtccttt ttggagcgtt
    19861 gaagcgttcc gttaccgtca tcatccagat caacgtaaat aaatccgtag cgcttggaca
    19921 tttcggacgt agacatgctc acaaggtcga taggtcccca actggtgtaa ccaatcagat
    19981 caacaccgtc agcaatcgct tccttcattt gggcaatatg ctgacgcaag taatcaatgc
    20041 gatacgtgtc atgcacagag ccgtcttctt ctaccttatc atacgcaccc aggccatttt
    20101 ccacgatgaa cagtggcttt tgatagcgat cataaaacgt attcagtgta acacgcaggc
    20161 cgatcggatc gatctgccat ccccagtcgg aagactgcag atacggattt ttcacaccgc
    20221 ctatcaggtt ccctgctgcc ttttcgcctt ctggccctgc cgatacggtc aaggtcatat
    20281 agtaactaaa tgagataaaa tcgaccgtgt tatttttcaa aatttcggca tcgccgggtt
    20341 ctgtctggat cacaatatta ttttcttcaa aatagcggtt catatagttg ggatattccc
    20401 cacgagcatg cacatccgta aagaacaggt tcatttgatt ttcatgctgt gctttcagga
    20461 tatcttctgg gttacacgta tgtgggtagc tttcaatgcg ggccagcata cagccgatct
    20521 gagcgcccgg aatgatttca tgtccccgtt tggtcgccaa tgcacttgct acaaattgat
    20581 ggtgcaatgc ttgatatatc gcttgttgct tgttttctac acggtcaata accacaccgc
    20641 cgcctgtaaa cgggctcata gtcatgacat taatttcgtt aaaggtcagc cagtatttta
    20701 ctttatcctt atagcgtgta aataccgttt cggcatattt tacgtaatga tccacgactt
    20761 cgcgtcccaa ccagccatta tatttctgtg tcaaacctag cggtgtttca taatgcgaca
    20821 gtgttaccaa aggctcaata ccatacttgc gcagctcatc gaatacattg tcgtagaatt
    20881 gcaatcccgc ttcattcggc tcggcatcat atccattcgg gaaaatccgc gaccagtgga
    20941 tggacatccg gaatacttta aagcccattt ctgcaaacaa ggcaatatct tctttgtagt
    21001 ggtggtaaaa gtccacacct tcacgttttg gaaaacgggc gtttaccttc cctgccaaga
    21061 tgtcctccag tcgttcggac gaaatttcta tagcatgatc gttcttacgt tctgatttag
    21121 gtacataggc tatcatgtct gcgctggata gaccttttcc atctacgtca aaagcacctt
    21181 ccaattggtt ggctgcagtt gccccgcccc agaggaagtt tttcgggaat ccttttagcg
    21241 tcttcgtcat ggtatgaaaa cctctttcct taatttaatg ttttcacttt agtcagtaac
    21301 ccgtcaggtg ctgcaatgcg aatccataac taacggtaac cgttctcctt tgaaatgcat
    21361 cgacagatgc tttaaaatag acgtaatgcc ctcataaagc atcctaattg ttgtaacgcg
    21421 tttcatgtca agtatttttt tctcaggtga ggagaagcat catgtcgaat cttgatcaaa
    21481 ttgcaaaact ggcgggcttt tccaaagcta cggtatccag agtgttgaat cagtcccccc
    21541 atgtaagcca agaaaccaga gctaaaattt taaaaataat gcaggaattg gattatgttc
    21601 ctaatcggaa tgcgatctct ctatccaagg gtcagacgct tcagattggt atcatcactt
    21661 caactatcaa tgaaattgtg ctggcatttc tggacagctt tgtggaaatc gcaggccaat
    21721 atgaattcca aaccattatt tatacttcgg gagaagacaa aaagaaagag cttcaagctt
    21781 tcgaggattt aaaaagaaaa agagtcgatg cgctggtcat catttcctgc gtgaatgaca
    21841 ctgatttttt gagtacctat tgcaaatatg gaccgatcgt ggcatggcaa cgaatggagc
    21901 atactgatat tcgctccgtc gctatggacc agtatgaagg atacatgtta gcattaaaac
    21961 atttgataca aaaaggctat acacgtatag ccaatgcttt tggtcgtccg agcagcatca
    22021 atactcacag cagacaacga gcctatgagc agatcatgag tgaacacaat ctgccggtgc
    22081 tgccacactg gaactattct tctatttata acattcgtga tggcgaacag gtcgtgcgca
    22141 atttgttaca gcatcgtgag gaatttccgg aggctatctt gtgtgctaac gattatgtag
    22201 cagtgggcat tctctgcgaa gcgcgcagac aattgctgag ggtaccggaa gacttggcga
    22261 ttgttgggtt tgataacacg gagctggcgc acaccatggg cattacaacg gttcaaaatc
    22321 ctattatggc tcaggcacaa aatgcttttt tcatgctttc ccctcagctg attggacgcc
    22381 aaatggagct tcattcgcta gaatacagcc tcatagagcg tacgactact taagggcaca
    22441 attgacttgc aaattaggca aatgggcctt gatatgaaat attttttgtc gaaagagaat
    22501 aaaatatgtt gaaatcgctt ttttttgtgc tacaatagca ctatatcgaa ggattgtgac
    22561 cggtgatgcg ggcaatgcct gagttcaatt gagtgctatt gctaacaata gtgttgaatt
    22621 gtgcttgggc attttttatt ggtaaaggat gggaggggga acttcaatga ttattgagaa
    22681 ggtgctcaat aacaacgtcc tgttgactaa aaacgataaa ggcaaagagg tcattgtcat
    22741 gggaagaggt atttccttca aaaaggtggc tggggaccaa gtcgatgatc ataaaataga
    22801 taagattttc atgttaaatg aaaacgagtt cacggccaga ctaactgagc tgctaaacga
    22861 tattcctgtg tctcatctgg aggtcgtgaa tgaaatcgtg acccatgcag ccgaagtgct
    22921 ggatacggag ttaagtgata acatttattt aacattgacc gaccatattc attttgccat
    22981 acagcgggaa gaaaaaggat tggcactcaa aaacgcgatg ctgtatgaaa ttaaacgctt
    23041 ttacaaaaaa gaatttgcag ttgggctgga tgctctacaa aaaattgaaa atacgctcgg
    23101 tgtaaaattg ggcgaagacg aagcgggatt tattgcactg catatggtga atgcacggat
    23161 tgatggtaac gagatgaagg ctacactgaa aatgaccgag attgtccaac acatattgaa
    23221 tattattacg tatcattacg ggattgtgct ggatgagtct tcttttagct attcgagatt
    23281 tttgacccat ttgcaatatt ttgcaatgcg agtgattcgc aaagaggtta ttcacagtgg
    23341 tgaagaattt ttgtacaacc aggtaaagca aacatatacc gaggcttttg cttgtgccca
    23401 aaaaattaat gagtatctgg aaaaaacata tgatcaatat ttaagcaaag atgagtatgt
    23461 atatctaacg attcacattc atcgggtaac tgagcgtaat aacatatcag gctaaaaact
    23521 ttatatcctc atcgttcatg gattgtgact ggtaaggcag gcaaaaccta aactgatggt
    23581 gaaatcgacg ttcccttata ggaggagtgc gcagttttca ccacgagttt aggtttttct
    23641 tgtttacaag gttaaaaaag atgcacgccg gcgcatctca gcaacaaatg taaacggtaa
    23701 atcctatcag tagcaagaat aacacttaag gagttctgaa catgagtgat aaagagctat
    23761 ccaaaaaaat agtgactctc gttggcggcg aagagaatgt caattcggta ttccattgcg
    23821 ctacacgctt gagatttaaa ttaaaagatc gcacaaaagc ggacaaagct gcactggaag
    23881 caacacctgg tgtcattaca gtggtggaaa gcagcggcca gttccaagtg gtcattggta
    23941 acaatgtagg tcaggtcttt gagcatatga tggcagaaac aaatctgcag gatgcagata
    24001 atccaaatgc gaaaaaagaa gaatcttccg aaaaaacgaa ttttcttggc aaagcggtcg
    24061 atatcatttc cagcattttc tcacctctct tgggtgctct tgccggagct ggtttgctca
    24121 aagggattat ggccttaatt gcgtcgctcc attggattga tactgcaagc ggtacgtatc
    24181 tcattctgaa cgccgcttcg gacagcgtgt tttatttctt gcctatattc ctagctatta
    24241 catcgtcccg taaatttaag acgaatgctt ttgtatcggt cgcagttgct ggagccctcg
    24301 tctacccgga tgttattgct gcggtggacc atccggcaaa actggctttt ctcggaattc
    24361 caatcattct gattaaatat agttccagcg taatcccaat tattctcgcg gtatgggtac
    24421 agtcctatgt ggaacgttgg tttaattcct ttgttcatca atcggttaaa aacattatcg
    24481 tccctatgct atcactacta gttgttgttc cgttgacgtt tttggccttt ggtccagtcg
    24541 gtaacctgat cagtcaaggc ttggcgaacg gttttacatg ggtgtacaat ttaagcccat
    24601 tgattgccgg agctgttgct ggggcattct ggcaagtctt tgttattttc ggcgtacact
    24661 ggggcttcgt tcctattatg ctgtccaata ttcaaacatt gggttatgac acgatgcttc
    24721 caatgcttac agcagccgta ctttctcaag cgggtgcaac actgggggta ttcctgaaat
    24781 cacgaaatac tcaaatgaaa gctttggctg gttcttctac actggcagct gtattcggga
    24841 ttactgaacc tacgatttat ggtgtaactt tgaaattgaa aaagcctttc atttacgctt
    24901 gtatttctgg tggtatcggt ggcgctatta tcgcttccgg cggagcaact gcaaaatcct
    24961 tctccctgcc tagtttactg gcgttgccaa cttattttgg agctgggttc ttgtgggttg
    25021 ttatcggctt actcgttgcc tttgtacttg cagttgtatt ggttatgatt ttgggctttg
    25081 atgatccaaa agaagaagct gcaaaaacag aaacagcacc cgtaaaaaaa gaagtagcca
    25141 tcgaaaaaga aatcctcgta agtccgctgc aaggtaaagt gctgccattg gaacaatctt
    25201 ctgatgttgc ttttgcttca ggcgctatgg ggaaaggaat cttgatcgat cctacagagg
    25261 gtgtgctgac atctccggtt aacggaacga ttacgacagt attcccgacc ggacatgcca
    25321 tcggtattac ttccaatgac ggagcggaaa ttttgattca cgttggtgtt aatacagtga
    25381 agctgaaa
//
