LOCUS       NZ_CP092779            27010 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Paenibacillus polymyxa strain ZJ-9 chromosome, complete genome.
ACCESSION   NZ_CP092779
VERSION     NZ_CP092779.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 5755887)
  AUTHORS   Zhang,Y. and Gao,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-FEB-2022) School of Chemistry and Chemical
            Engineering, Yancheng Institute of Technology, 211 Jianjun East
            Road, Yancheng, Jiangsu Province 224051, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 265.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022492955.1-RS_2024_03_30
            Annotation Date                   :: 03/30/2024 06:30:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,104
            CDSs (total)                      :: 4,947
            Genes (coding)                    :: 4,884
            CDSs (with protein)               :: 4,884
            Genes (RNA)                       :: 157
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 111
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 63
            CDSs (without protein)            :: 63
            Pseudo Genes (ambiguous residues) :: 0 of 63
            Pseudo Genes (frameshifted)       :: 34 of 63
            Pseudo Genes (incomplete)         :: 30 of 63
            Pseudo Genes (internal stop)      :: 14 of 63
            Pseudo Genes (multiple problems)  :: 12 of 63
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:24:45
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1726604
            Orig. end                         :: 1753614
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP092779.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jian Gao, 211 Jianjun East
            Road, Yancheng City, Jiangsu Province.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..27010
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="7"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27010
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27010
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17010]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17010
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(400..417)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.88"
                     /tool="antismash"
     misc_feature    complement(468..482)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 20.57"
                     /tool="antismash"
     gene            1671..2852
                     /locus_tag="MJ749_RS07395"
                     /old_locus_tag="MJ749_07395"
     CDS             1671..2852
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820485.1"
                     /locus_tag="MJ749_RS07395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07395"
                     /product="hypothetical protein"
                     /protein_id="WP_017426672.1"
                     /transl_table=11
                     /translation="MMKKNLDSYGQKNGFPRLEYPYARFFRHKVTGLLMTGLIAGGLLS
                     GCGIKSAGETIPTSGMKTGQKLTVIDMDAARQQVSDELVVQSIDRLGDVYARSWLSDEE
                     LIVERQNQLWIHNVKTNKERVLTPGRNALQLLAVVSPDQRHVFFTEGSASSKYDIQGYI
                     LELSSGKVTSVGQLDMTNEVSWGDKDHLITGTPDGKIHLIGLNGKAEELSFQDPNHSEL
                     IAHVEKVGNDIFYTGNDKQGYPVLNRFSLNHPQAVTIAEGAMSFAVSLDGKSIAIEKRK
                     WNTSEPARMIILDEQGKEKGIVGQGTLMSRGSWSSDGTKLAFSIYDEDQQGMRGLYVFD
                     QSTGKTTPVTTDIQSYDSPTVWSPSARFLSMYQNISEGGKQLNQSYIVEFKKK"
     gene            complement(2921..4366)
                     /locus_tag="MJ749_RS07400"
                     /old_locus_tag="MJ749_07400"
     CDS             complement(2921..4366)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686782.1"
                     /locus_tag="MJ749_RS07400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07400"
                     /product="SpoVR family protein"
                     /protein_id="WP_102997733.1"
                     /transl_table=11
                     /translation="MSTDQKELEYAISEIMEIANGFGLDYYPMRYEICPADIVYTFGAY
                     GMPTRFSHWSFGKTFHKMKMQYDFGLSKIYELVINSNPCYAFLLDGNSLVQNKLIVAHV
                     LAHCDFFKHNARFSASNRNMVESMSATAERISSYEMEYGSKAVESFIDSVLAIQEHVDP
                     QLIKPRHLDKQRYMELKIKEQKEPKKHQRPIGPYDDLWSLDTVKQHDSAETEGIKVRQF
                     PPEPEKDIVWFIQEFSEVLEDWQRDIMTMLRDEMLYFWPQMETKIMNEGWASYWHQRIV
                     RELDLTGDETVEFAMLNASVVQPSKQSLNPYYLGLKIFEDIEKRWDNPTREEQERQGRK
                     PGEGRAKMFEVREFDSDTSFIRNYMTKQLTEDLDLYVFEKRGPDWKITDKSWENIRDQL
                     VFSRVNGGSPYIVVEDGDYLHTGELKLKHQYEGIELDLKYMERTLPYVYQLWGRTVHLE
                     TMIEGKLALFSYDGKKHHRKFVQ"
     gene            complement(4363..5529)
                     /gene="yhbH"
                     /locus_tag="MJ749_RS07405"
                     /old_locus_tag="MJ749_07405"
     CDS             complement(4363..5529)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yhbH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370159.1"
                     /locus_tag="MJ749_RS07405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07405"
                     /product="sporulation protein YhbH"
                     /protein_id="WP_016820483.1"
                     /transl_table=11
                     /translation="MTEPRQPYSFVVSREDWSLHRKGYQDQQRHQQKVKDVIKQNLPDL
                     ITEENIIMSDGQQIIKVPIRSLDEYRFIYNYQKQKHVGQGDGDSQVGDVIGRDPASQKP
                     GKGEKAGDQPGHDIMETEVSIEELEDMLFEEMELPHLQQKDKDQIEVESIVFNDIRKKG
                     MQANIDKKRTILENLRRNAREGNPGIHHISPDDLRYKTWEEKTIPQSNAVIIAMMDTSG
                     SMGSFEKYCARSFFFWMTRFLRRQYEKVEIVFLAHHTEAKEVTEEEFFTRGESGGTICS
                     SAYLKALEIIDKRYPPSTYNIYPFHFSDGDNLSSDNERCVKLIEELMKRSNMFGYGEVN
                     QYNRSSTLMSAYKNIKADQFMYYVIKEKGEVYQALRTFFRKREGGTVG"
     gene            5693..6412
                     /locus_tag="MJ749_RS07410"
                     /old_locus_tag="MJ749_07410"
     CDS             5693..6412
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686783.1"
                     /locus_tag="MJ749_RS07410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07410"
                     /product="response regulator transcription factor"
                     /protein_id="WP_025364471.1"
                     /transl_table=11
                     /translation="MEEIAVLIVDDEQGLRDMLTTVLKKEGFLHVKHAATGQEALQIVM
                     ESRIDVIVLDVMLPDRDGFEVCRQMRLYTEAPILFLTARDTDLDKLMGFGIGGDDYITK
                     PFNPLEVAARMKARMKYRKVTTADMKPALRTLDFGYFCLELESGVLYVQDQEVDCPARE
                     WLLLVFLCKHPNRIFSVRQLYEAIWSETFLGDEKTVVIHISRLRKKIEPDPKHPQFLVN
                     VRGLGYKMISVKRGEQE"
     gene            6544..7479
                     /locus_tag="MJ749_RS07415"
                     /old_locus_tag="MJ749_07415"
     CDS             6544..7479
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686784.1"
                     /locus_tag="MJ749_RS07415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07415"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_235193642.1"
                     /transl_table=11
                     /translation="MNIDLFWIGLGIVQSLVFIVVYGWYIGKPLVYVIKWIGNIATGEF
                     QAPLSELELPERKKNQRNNYKPPYQLYKEVFEQMNILSAQLRSNEEERIEIEKRKQQWV
                     AGVSHDLKTPLSYIEGYAAMLTTQEYDWSDEEKRSFSMAISEKVTEMKQLIQDLNASMQ
                     LKEGALPIQLKKEDIVEFLRNTVIDIANHPSAEQYEFSFMSLEAVCTMPFDSKLLGRAL
                     KNFLMNAIIHNPSGTHISMDVNKESDKLHISIEDDGKGMNPTECIQVSHSKEHGISIAK
                     SFIEAHNGTLHILPGSKKGTRVEITLPLNI"
     gene            7625..8548
                     /locus_tag="MJ749_RS07420"
                     /old_locus_tag="MJ749_07420"
     CDS             7625..8548
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426675.1"
                     /locus_tag="MJ749_RS07420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07420"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_025364473.1"
                     /transl_table=11
                     /translation="MSEYVIHTQQLTRRFGKREFVKQINLQVPEKQIYGFLGPNGAGKT
                     TTIRMLLGLIKSTSGEIEIFGKKLKDHRMEILKDVGSLVESPAYYAHLSAYRNLEIVTT
                     MRGLPTRKINKVLDLVRLSKDAYRPVKGYSLGMRQRLGIAMALIADPKLLILDEPTNGL
                     DPSGIQEIRELIMSLPDAYGMTVLVSSHLLSEIEQIATYVGIINQGEMIFQGTMKELTD
                     KSKPQLFIETQNPVQAAGALMQHGWIAGAESLEQKEVITPIVDRQQSSEMIKVLVEHNH
                     PVYRVREKKKTLEEIFLELTGKERSL"
     gene            8545..9252
                     /locus_tag="MJ749_RS07425"
                     /old_locus_tag="MJ749_07425"
     CDS             8545..9252
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370164.1"
                     /locus_tag="MJ749_RS07425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07425"
                     /product="ABC transporter permease"
                     /protein_id="WP_016820479.1"
                     /transl_table=11
                     /translation="MILQVIKAEGYKLKKICWWLPLIQGCVLTGMTVMEWYLYFRQGPG
                     GVYAGFAVMFMFISFVMLLGGTLLASIMAGTEHDTQTWKQLMAMPVPRSYIYLSKMFWI
                     VILQFGTALITIAGMSLIWVLYTNEPIPWRVMLLQPINASLATLPVLAIQLWLSTLFTN
                     QAFPLAFGIFGSIASLFLARTSILWIKLLPWSYPALSSPLIKGYVMWVIIALCAGVIFT
                     GLGTLQFRKHEFK"
     gene            9266..10000
                     /locus_tag="MJ749_RS07430"
                     /old_locus_tag="MJ749_07430"
     CDS             9266..10000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370165.1"
                     /locus_tag="MJ749_RS07430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07430"
                     /product="ABC transporter permease"
                     /protein_id="WP_025364474.1"
                     /transl_table=11
                     /translation="MGSILRVEAMKLQWVMVWILIILSAVINSLMGVLELNDLKQFYEP
                     SWLMLYTYAAQFHSMFFYPLYCGIIASLLCAYEHRDGGWKILLSSPYPRQRIYYAKYIL
                     LILILFLDQLTFIVGYFVGGYIAGAPGKIPWLLVLSTGWGGWFGILPLAALQLMLSVKI
                     RNFGASLGMAICCVVPNIVMTGFHSSIGAWFPFTIPYYIMLPQTASYAPRVEPYSLGLI
                     VLFTFLACLFAGRKMFVNRDWL"
     gene            complement(10001..11362)
                     /locus_tag="MJ749_RS07435"
                     /old_locus_tag="MJ749_07435"
     CDS             complement(10001..11362)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370167.1"
                     /locus_tag="MJ749_RS07435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07435"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_025364475.1"
                     /sec_met_domain="LANC_like (E-value: 1.8e-54, bitscore:
                     183.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTDHFVMEACEQLQAKDFSTTIALRLSNPESVYKAVHAEQNISP
                     ETKYHPWGDTSLSHGYPGNIFLLSQCRASDSTYDWNQAIYLNMKHIQASLAKKGLNDVS
                     LYSGWTGIASSVREASNHGEYYSHFLQQIHEWMIPLTEQWLQLNTAQLALHEGMPMQSF
                     DTISGASGIGRYIVMNSIDPSCTPLVEPILQFLTDLTYPIKIHNRYVPGWYSPQKFQFL
                     DRDKSNYAMGNFNCGMAHGIPGPLALLSVAYSSGIEVKGQYQAIETITEWLLKYKNEDT
                     YGYYWPHIVPFEAETGSLQLDLKRAREAWCYGTPGVACSLYLAGKALHNEELQKMAVMA
                     CIGAITYEVTKQEMDSSALCHGLAGLLTISWRMWCHSKEPAFIPLIQHLTSQLIDRFQA
                     DSPLGYLDPEPRADSSLAWLTKAGLLEGVAGIASALLSVSENKEMPWDYMLMLS"
     gene            11560..11712
                     /locus_tag="MJ749_RS07440"
                     /old_locus_tag="MJ749_07440"
     CDS             11560..11712
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820476.1"
                     /locus_tag="MJ749_RS07440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07440"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_016820476.1"
                     /sec_met_domain="TIGR03731 (E-value: 6.3e-06, bitscore:
                     24.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQFDLDLQVAKNEVAPKEVQPASGLICTPSCATGTLNCQVSLS
                     FCKTC"
     CDS_motif       11560..11631
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNQFDLDLQVAKNEVAPKEVQPA"
                     /locus_tag="MJ749_RS07440_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       11632..11712
                     /prepeptide="core"
                     /locus_tag="MJ749_RS07440_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="5.70"
                     /molecular_weight="2493.9"
                     /monoisotopic_mass="2492.2"
                     /core_sequence="SGLICTPSCATGTLNCQVSLSFCKTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNQFDLDLQVAKNEVAPKEVQPA"
                     /leader_location="[11559:11631](+)"
                     /alternative_weights="2511.9"
                     /alternative_weights="2530.0"
                     /alternative_weights="2548.0"
     gene            11788..13053
                     /locus_tag="MJ749_RS07445"
                     /old_locus_tag="MJ749_07445"
     CDS             11788..13053
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820475.1"
                     /locus_tag="MJ749_RS07445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07445"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_016820475.1"
                     /sec_met_domain="LANC_like (E-value: 5.6e-55, bitscore:
                     184.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGDLQERSVEISKNITQKLIDLSYTEKIVHHRNNLSPSRGTAPW
                     NPGWLADGVPGVFVLLAEWGYLKPDQNWAEHVHTQLLYLHRNSLILLPDISLYYGSTGV
                     AYGILLASNNRANYQQLLNQINDYIRTQWVKSPVINTITEFSKQMDVIHGLLGVGRYTL
                     EIPEDDEKMCNLTHQLLDTITHFIPEYIHSVSRGSSTSIHLGMAHGITGILALLVTALQ
                     KKIRVKGLHEAIEYIADFLLIQIQEDQYGLYWPVSSQATSMNKTDNKEGMREIEGWCHG
                     TCGIAWTLFRAGMECSNEEWTKIAEQAMKSVFCLDDELLNALSPTFCHGLAGLLHMAHR
                     FYYFTGNQAALGFADQIALKLMNLYDEELPFGYQDLEGTTHVHNIGILQGATGIALSLL
                     DYGVGKEQPKYSGRWSELFLIS"
     gene            13104..13781
                     /locus_tag="MJ749_RS07450"
                     /old_locus_tag="MJ749_07450"
     CDS             13104..13781
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820474.1"
                     /locus_tag="MJ749_RS07450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07450"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_016820474.1"
                     /transl_table=11
                     /translation="MKQKFMVISSFKKIKHFFETLSTPENIQIMFYDSLYQALPDIDEQ
                     CIGVALNQDHVTLEDLSHWHTIKEKFTVPFIFLSYHCDDKRQLDLLKQLLSMASSEYGL
                     ERDQEAISLSPNVIFDPAGKVIWKQGHEHMLTMMEFRLLMYLLTAKECASTIDHIIDRV
                     WGVDAFTTSNTVYVHIRKLREKIEDDPSHPKILVTCHGIGYRLNIFPKNLEVASCEETT
                     ALH"
     gene            13756..17010
                     /locus_tag="MJ749_RS07455"
                     /old_locus_tag="MJ749_07455"
     CDS             13756..17010
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820473.1"
                     /locus_tag="MJ749_RS07455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07455"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_240753628.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.6e-196,
                     bitscore: 651.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.4e-17,
                     bitscore: 60.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.9e-56, bitscore:
                     189.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRQLHYTDAHNLHREPRDKNERWFSACDYFLIRAPLLPLEQYFE
                     VFSDQDVDSHLSLEEITRRLKLVSREAVIREAISLASPSLMQFLHYLNDDDALEDKGEL
                     QKYEKTLNSFYRYFIRMTTRTTPFGLFSGVGQGICKDTTHLDIGTYHQHLKRARPDMEW
                     IYKIIRKMESDPVIFDQLKVFLNRTVMIKGDRAKLPFRPKHGAAETDDSAEMFSSIRLT
                     DVVRLTFEAAEHPIQVMELKELLLKAFPDATTEIIAHFLQQLVEQEFILSELRPPLMDH
                     SPFHYIFEKIKKMDMSDYWTDILHEIDILLRQYNQCMIGEGEKAYRELCGKMLDIIAVK
                     TPVQVDVKLAQEVTLPRHVLDDVALGAEVMCRLFSSPKMDELDEYLNRFLEKYGVYQEV
                     PINELFDEDWGLGIPKTYRTNEKKSMGMEAFKRNAVLFQWLSNAIANHDIEIVLSDEQL
                     EQLTISDNDDTSPESMEVYYSIFAESPEKVDSGDYKLLLGPSAGSNRAGKTFGRFLDMF
                     SEEYVQKFSDIYDHHRCFHPDALLAEMVFMPDQGKISNISLSKNFMEYEIVSGTTSSKD
                     EEQTLHMDDLLIGATHDRFYVKSRRLGKEIIPLQTHMLNYKLSPHVFRFLTDITNKELG
                     TWSYFDWGPLEQSPFLPRLVYGKIVISAAQWRLGKAALNISDLTEPQAREELFHTWREQ
                     WNVPRYVYLTMGDNRLLLDLCNLLHIKELLREMSKMREGQELLLTECLGDPFHTPLHGT
                     AGRYMGEFVFPLKKKKIKGKPSIPSLPHKMDSQKFMAYTPSGIHRGFLPGGEWLYLKLY
                     GVKERETDLISLSLDQLRNNPEFEDWSKKSYFLRYVDPEHHIRLRFQGEPGQLWSAGLA
                     QLNQWAGELREEGLITHMVLDTYLPELERYGGQTLMDLAEQVFDVDSRWVIAYMAGIRS
                     KAFNLDIEIAAVINIIHYLSSFGLTIQEQVDWLEGRIDSKPYMKAFRDIKKALITAVES
                     EYEWIRQADTATQVALLALVEKRQAMIQQYAQAITLAENNHELTNHANDILGSIIHMHL
                     NRLLGVNREREMKCMALAKHTAANLLHRKGVRHVTV"
     aSDomain        14302..14586
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MJ749_RS07455_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.50E-19"
                     /identifier="RREFam001.1"
                     /label="MJ749_RS07455"
                     /locus_tag="MJ749_RS07455"
                     /protein_end="277"
                     /protein_start="182"
                     /score="60.7"
                     /tool="antismash"
                     /translation="VFLNRTVMIKGDRAKLPFRPKHGAAETDDSAEMFSSIRLTDVVRL
                     TFEAAEHPIQVMELKELLLKAFPDATTEIIAHFLQQLVEQEFILSELRPP"
     misc_feature    17125..17138
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.91"
                     /tool="antismash"
     gene            17165..18898
                     /locus_tag="MJ749_RS07460"
                     /old_locus_tag="MJ749_07460"
     CDS             17165..18898
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309469.1"
                     /locus_tag="MJ749_RS07460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07460"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_240753629.1"
                     /transl_table=11
                     /translation="MILLATRELINSVVAGASGGSFQPVFIAFGVLIGVNLLYDLINIG
                     ESFFRKMFQSRLSNQVNIRIIEKAQKMSLQSFEDADVQNMLQRAQGEADYRPFEIFTQI
                     LAIMSSMVTLFSTGAILIAWRWWAFLFIFLIPCLSFYSFLRIGQREFNVHFQRAGRQRE
                     SWYLSFLVTRDNSFKEVKIFQLGDYLRKRYKTILEGFYREDKVLAVRRSYTSLAFQIVN
                     QGACAFIIFMAIQATYVGQILVGNLVSLIQGITLTQSTSQSIVQGILSLCQNNLYIKQL
                     FDFLDMPEETKMQKSVQHLPLSAIHSIEFRNVSFRYPNTEENAISNVSFTLHQGEKLAI
                     VGRNGSGKSTIVKLLTHLYSDFEGEILINGHSIHELDKDSFRGKIGVVFQDFVHYEMSV
                     RDNIGFGHVASRENDEAIWAAIDKAGIVDLIAGLPEKLNTLLGKWFEDGQQLSGGQWQR
                     IAIARAFMRNADIYVLDEPSSFLDPHAEKEVFQKFDQLVHERIGVFISHRLSSARMADT
                     IILMKEGRIVEAGSHKHLMDMDGVYAEMFRLQASSYLSQGESELEQEMLSPPLVKATGG
                     S"
     gene            complement(18937..19266)
                     /locus_tag="MJ749_RS07465"
                     /old_locus_tag="MJ749_07465"
     CDS             complement(18937..19266)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820471.1"
                     /locus_tag="MJ749_RS07465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07465"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_016820471.1"
                     /transl_table=11
                     /translation="MNISPNVLYIIIGGMIVTAIPRIIPFVVLQKLTLPKPVLQWLSYI
                     PICIFTALVMENLLVRTETSVTLNGQVLIAVLPTLVTALWSKNLLATVVVGIVSMAVVR
                     VLWLG"
     gene            complement(19263..19988)
                     /locus_tag="MJ749_RS07470"
                     /old_locus_tag="MJ749_07470"
     CDS             complement(19263..19988)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820470.1"
                     /locus_tag="MJ749_RS07470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07470"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_016820470.1"
                     /transl_table=11
                     /translation="MSIASELSGTKPDSLSVLQGVKDCIPTLLGYVCIGFAAGIVGASS
                     GVSTMEIGLMSALVYAGASQFIMCSMLAAASPPSVIILTTFIVNARHLLLSASLAPYFS
                     KYSLWKNIGIGILLTDESFGVASDKLAKGGQVSDRWMNGLNITAYLAWIASCVAGGVLG
                     NWISQPEAFGLDFALPAMFLALLISQLQSVQTSKLKHRLLLVLCMAVLMYLLSWWVPSH
                     IAVIVATMITATIGVLTDK"
     misc_feature    20008..20021
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.91"
                     /tool="antismash"
     misc_feature    20083..20098
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.02"
                     /tool="antismash"
     gene            complement(20165..21403)
                     /locus_tag="MJ749_RS07475"
                     /old_locus_tag="MJ749_07475"
     CDS             complement(20165..21403)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426681.1"
                     /locus_tag="MJ749_RS07475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07475"
                     /product="MFS transporter"
                     /protein_id="WP_240753630.1"
                     /transl_table=11
                     /translation="MNPQTRKSRHMYMMQLATIFIGFIVFGISENIKGPAIPRIQFDFN
                     MDEQQLGTLLSLNALGYLIACSFTAVLVRKWGIKAVSIISFASMIISGVFIYLSHTYPF
                     FASSYFLMYIGNGMLEIALAILGARIFVKNTGTMMNLSHFFYGLSSTVAPLLATGVMSL
                     TVFGHTLDWRGMYLAMLSLCLLPIVAALLSTFPGDDLQHEERTSLKTLTRDPALWMMVM
                     ILSFGVVSELAVGGWLVNFLEKAYSWSTVKASSMLSAFFLTFSLGRLLLGPLTDRMGFV
                     LSTILFSAFSAICTFAAIAGGERLAFLFAASGAGIAMIYPTVMAFIARRYPKDSDTAIT
                     FVVTLMGIGSVIGNYVIGWVIEGVKIVYGATTELGILRGLQAGYGVIGLCAAICAVSGM
                     ILYGYLKKRQELI"
     misc_feature    complement(21481..21490)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 17.33"
                     /tool="antismash"
     gene            21637..22185
                     /locus_tag="MJ749_RS07480"
                     /old_locus_tag="MJ749_07480"
     CDS             21637..22185
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429618.1"
                     /locus_tag="MJ749_RS07480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07480"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_016820468.1"
                     /transl_table=11
                     /translation="MDSMQYIIGSNLAQIRKTRGLSLDKVAELTGVSKGMLAQIEKGKS
                     NPTVTTLWKIANGLHVSFSTFLKEDPPQITKIRRADLHPVIDEDGNYFVYPVFPYHSEK
                     KFEVFTVSLKPGFTHKAEEHLGEETILMIRGEMYFEMQGQQLRLSAGDAVQFQGSDIHT
                     YRNDSDEDADFYVLIYYAD"
     gene            22285..22800
                     /locus_tag="MJ749_RS07485"
                     /old_locus_tag="MJ749_07485"
     CDS             22285..22800
                     /EC_number="3.1.2.20"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /function="acyl-CoA hydrolase"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014599583.1"
                     /locus_tag="MJ749_RS07485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07485"
                     /product="acyl-CoA thioesterase"
                     /protein_id="WP_014599583.1"
                     /transl_table=11
                     /translation="MESKYIRETYCFKTSRVFPNDINNHNTLFGGRLMSYIDDIASIAA
                     AKLCRTNTVTASTDSVDFLLPIHPSDSVTLEAFVTWTGRSSMEVFVKVIREGLMTGDRK
                     IAATAFLTFVALDENNRKVTVPQVIPETEEQIQLHQTAPSRAAIRRQRREESKQLASFL
                     TTDFPWEV"
     gene            complement(22909..24375)
                     /locus_tag="MJ749_RS07490"
                     /old_locus_tag="MJ749_07490"
     CDS             complement(22909..24375)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686791.1"
                     /locus_tag="MJ749_RS07490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07490"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_025364479.1"
                     /transl_table=11
                     /translation="MKYDFARLLCIMLTILLSLSIFQMFSPKIASAASANVVNGIQFKD
                     TDGNVVHAHGGGMIKVDGYYYWFGENRNPNGTFKAVSAYRSSDLKNWEFRKNVLTSSSA
                     AELNVSNIERPKVIYNEKTRKYVLWMHKENGINYNEARVAVASSDTVDGDYTYQGSFRP
                     LDYDSRDMTVYNDNGTAYLISATRVNADLNIYRLTPDFLQVESLVTTLWPGQYREAPAM
                     FKKGDVYFLITSGATGWNPNQAKYATASSIEGTWSNTMNFGDSTTYGSQSAYVIPVEGT
                     QTTSYLYLGDRWAGAWSGPVQDSQYVWLPLRFPTATSLAMDWFDSISIDTASGVVEGVT
                     TPMVIDPDAYYQLVSRKSNKPLGIIGNATTDGADLEQRANSGAPSQQWQLKDAGGGYYK
                     IVNRNSGKLIGVESGATADGAVIEQWNDGGWSSQHWQLVSVTGGYYKLKNRATGKLIDI
                     SEGATADGAKAIQWGDNGGTNQHFRVVKVE"
     gene            24602..25303
                     /locus_tag="MJ749_RS07495"
                     /old_locus_tag="MJ749_07495"
     CDS             24602..25303
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (103-161). E-value: 2.8e-12. Score:
                     38.6. Matches aSDomain:
                     nrpspksdomains_MJ749_RS07495_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426685.1"
                     /locus_tag="MJ749_RS07495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07495"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_016820466.1"
                     /transl_table=11
                     /translation="MEIYAIDTSKPEAEEHYELLVNQVSLEKQHKLDRFLHREDALRGL
                     YADVLLRWLVCRQLKIPNASLQFTYNAFGKPSLLNAPAFHFNVSHSGKWVVCAIDDHPL
                     GIDIEQLRPIDFEVGRVCFSDTEYDALMQQDAESRLDYFYDLWTLKESFVKAEGQGLTL
                     PLKSFSFELEARPSIGFTTEGFTTEYCHFKQYNELDPDYKMAVCAAHDHFAQEVQQVDI
                     NTLRLEVATLA"
     aSDomain        24911..25084
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MJ749_RS07495_ACPS.1"
                     /evalue="2.80E-12"
                     /label="MJ749_RS07495_ACPS.1"
                     /locus_tag="MJ749_RS07495"
                     /protein_end="161"
                     /protein_start="103"
                     /score="38.6"
                     /tool="antismash"
                     /translation="LGIDIEQLRPIDFEVGRVCFSDTEYDALMQQDAESRLDYFYDLWT
                     LKESFVKAEGQGL"
     gene            25351..26940
                     /locus_tag="MJ749_RS07500"
                     /old_locus_tag="MJ749_07500"
     CDS             25351..26940
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370180.1"
                     /locus_tag="MJ749_RS07500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MJ749_07500"
                     /product="amidohydrolase"
                     /protein_id="WP_025364480.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.8e-11, bitscore:
                     42.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFVLFKRGRLYGDWASKGDSIVVQHGRIQAIGYARELELQLSGK
                     EYETVDWEGANVLPGLTDAHMHLSMHGMKLAMLDFTSATSKDEMLAMLRKRVAVTPPGE
                     WILGLNWNENAFIPVEIPNIAELDAITDQHPVYLTRTCFHTFLANSEAFRRAGIHENTP
                     DPASGAYGRDAEGRLNGLIYEEASFAFTSVQPEPDYSAKKDTIRRACLDALRLGLTAAH
                     TEDLRFLGSVETMQRIYKELREEGLAFRTHQLIYHPFMEEVKVQELRAGTGNEWFKIGA
                     IKIFADGAIGGRTALLSEPYSDAPHTCGMAIQPQPELNQMVAAARAAGFPVAVHAIGDG
                     AAHMILTAMEAHGLTEESGLPDRLIHGQVLRADLVKRMAKLPLIADIQPRFVASDFPWV
                     LDRVGKERTEYLYAWKKLLQAGIPCAGGSDAPIEPLNPFLGIHAAVTRAKPEEMHEGYL
                     PAEKLDVHEAIHLFTMGSAVAAGEADERGTIAEGKAADFTVIDRDVSESHQALLDVKVR
                     MTVVNGQVAYQS"
ORIGIN
        1 gaaggaagct tgcagtccac tgaccagcca aagcgcaaac gtaagcgtac aggcttgagc
       61 ctgcgctgga aatttccgct ggtcctggcg gctttactgc tgtttactgt cggtgtgctg
      121 agctggctcg tacttaccgg tattcgtgct aatcagacag accaaatgga acgcggctta
      181 aagcgtcagg cggaaatcgt ggagatgcgc gtaaaacagt cttacctgtt gggagttcac
      241 caatcgcccg aagacttcat gaaaaagcaa gcaccacagc ttgccgtgga gcttggcgta
      301 tccagtaata tgcgcgttat tttatatgat ggccggggag atgaggtcgg aaattctcta
      361 ccactggctt atagaacaaa cgtcggccag gcgctttctt atgcgctcca agggaaaatt
      421 gcgtatatta cggaaggtag ctcagttact tatttggctc cgctgcaagg tccggacggc
      481 ttgctgggag tggtacagct tcatagctca acagaagcgc agcagcagtt ttaccgggcg
      541 atcgcccgct tgtttttatg gacaggaggg gcggtgctgg ttttaagctt tattttgggc
      601 ttaggctatg tcagccgcca gacgagggac atcggacgac tgactcgtgt ttctgagcag
      661 atctcggcag ggcactatcc agaagctcga ttgctgcgac gtcaggacga gctaggaagg
      721 ctggatgaag ggatgctcca gatgagtcat gtgatccggg ctagtattac cgcgctcgag
      781 aatgaaaagc ttcggctgga agaagcagtt cagcgtttgc gagagctgga gcagcagcag
      841 aagactttta ttggcaatat cagtcatgaa ttgaagactc cgttaacatc tattcaggct
      901 tacgctgatt tgctggatat gtatggggat gatcccgaat tggtgcgtga agccagagaa
      961 agtatcggta aggaaacaaa acggttgtat gagcttgtcg aggattcact gagactatct
     1021 gtgctggaca aatacgattt tgaattacat acggaggaag tggagctgca tttgctgctc
     1081 gaagatgcag gtagccgaat ccgggggaaa gctgcggcgc gtggactaaa tttttcgatg
     1141 gataccattc cagccaaggt gtgtggagat cctaagcatc taatgcatat tgtactgaat
     1201 ttgctggata atgcagtaaa atataatcag gacaaaggct ggatcacgtt atccaatcga
     1261 gtggaaaagg acactgtgat agtgtatata tgcaattccg gtccatggat tcctagggaa
     1321 gaatgggaca tgatttttga gccgtttgtt accttaagcc gtgatcgttc tcgccaggac
     1381 agtggtacgg gacttggcct gcctctggca cgcagactgg cggagcgcat gggtggagag
     1441 ttgcagctta cagcttcggg cggtactggg ttggaaaata gcaatggtca ttcagttgca
     1501 agtggcaatg aattttcgct caggctcccc ctgttggttc acgatggctc tcagtagata
     1561 gctttagaac tgaaaatgtt gtcttattta caatttggaa acaattcgat gtattcacga
     1621 gatgttcagg cattaagctg ggggtaacgt taacaaggag gccgttatac atgatgaaga
     1681 aaaacctaga cagctacggg caaaagaacg gctttcctcg tctcgaatat ccctatgcac
     1741 gctttttcag acacaaagtc acaggcttgc tcatgactgg cttgatcgct ggaggattgc
     1801 tcagcggctg cggcataaaa agcgcaggag agacaattcc aacatccggt atgaaaacgg
     1861 ggcaaaagct tactgtgatt gacatggatg cagctcggca gcaagtatcg gacgaactgg
     1921 tggtacagtc catcgacagg ctgggagatg tctacgcgag gtcatggctg agtgatgaag
     1981 aattgattgt ggagcgccag aatcagttat ggattcataa tgtaaagacc aacaaggagc
     2041 gagttttaac accaggtcgt aacgctctac agttacttgc tgtggtatca ccggatcaac
     2101 gccatgtgtt ttttacggag ggcagtgcca gcagcaagta tgatatccag ggctatattt
     2161 tagaactcag cagtggtaag gttacatcgg ttggtcagct ggacatgact aacgaagtga
     2221 gctggggcga taaggatcat ctcattacag gtacaccaga cggtaagata catctgattg
     2281 gtctgaacgg caaagcagaa gaactaagct ttcaagatcc gaatcactca gaattaattg
     2341 ctcatgtcga gaaggtgggt aacgacatat tttatacagg caatgataaa caagggtatc
     2401 cggtactgaa tcggttctct ctcaatcatc ctcaagctgt gaccattgca gagggggcca
     2461 tgtcttttgc tgtgtcgctt gatggtaaat ctattgccat tgaaaagcgg aaatggaata
     2521 catccgaacc agcccgtatg atcattttgg atgaacaagg caaagagaaa gggatcgtgg
     2581 gtcaagggac tttaatgagt cgtggaagct ggtccagcga cgggaccaag cttgcttttt
     2641 ccatttatga tgaggatcag caaggaatga gagggctgta tgtgtttgac caatccacgg
     2701 gtaaaaccac tcccgttacg accgatatcc aatcctatga cagtccaaca gtgtggagcc
     2761 cttccgcccg gtttttatcc atgtaccaga acatttcgga aggtggaaaa caactgaatc
     2821 agagctacat cgtcgaattt aagaaaaagt agtaaaaaaa ggcgcatttc cttcttcgga
     2881 atgcaccttt tttaaattag gctggctatt cgattgtggg tcactgcaca aacttgcgat
     2941 gatgtttctt cccatcatat gaaaataagg cgagcttccc ctcaatcatc gtttccaaat
     3001 gaacggtacg cccccacagt tgatatacat atggaagcgt gcgctccata tattttaaat
     3061 ccagctcaat gccttcatac tgatgcttga gctttaactc gcccgtatgc aggtagtctc
     3121 cgtcctcaac gacgatgtaa ggggagcctc catttacgcg tgagaacaca agctgatccc
     3181 gtatgttttc ccaggattta tcggtaattt tccaatccgg tccccgtttc tcaaacacgt
     3241 acaaatctaa atcctctgtt agctgcttgg tcatgtaatt gcgtataaaa gaggtgtccg
     3301 aatcaaactc tcgcacctcg aacattttag ctcggccctc gcccggtttg cgtccttggc
     3361 gctcttgctc ctcgcgagtc gggttatccc atcgcttttc aatatcttca aatatcttca
     3421 atcccaaata atacggattc aagctttgct tggaaggctg cacaacggaa gcattcagca
     3481 tggcaaattc aacagtttca tccccggtca aatccagttc cctgacaatc cgttgatgcc
     3541 aataagaggc ccagccttca ttcatgattt tggtctccat ttggggccag aaatacagca
     3601 tttcgtcccg cagcatcgtc atgatgtccc gctgccaatc ctccagtacc tcggagaatt
     3661 cctgaataaa ccagacaata tccttttcag gttccggtgg gaactggcgt accttgatcc
     3721 cctcggtctc ggccgaatca tgctgcttta ctgtgtccag tgaccacaga tcatcgtaag
     3781 gtccgatggg acgctggtgt tttttaggtt ctttttgctc cttgattttg agttccatgt
     3841 atcgttgttt atctagatgc cttggtttga tgagctgtgg gtctacatgc tcttgtatcg
     3901 ccagtacaga gtcaatgaag gattccacgg cctttgagcc gtattccatt tcatagctgc
     3961 tgatccgttc tgcggtggca gacatgctct cgaccatatt gcggttggag gccgagaagc
     4021 gggcgttgtg tttgaaaaaa tcgcagtgcg ccaacacatg agcgacaatc agtttatttt
     4081 gcaccaacga atttccatcc agcaggaaag cgtagcaggg attggagttg atgaccagct
     4141 catagatttt actcaatcca aaatcgtact gcatcttcat cttgtgaaat gtttttccga
     4201 aactccagtg gctgaagcgc gtgggcatac catacgcacc gaatgtgtat acaatatccg
     4261 ccggacaaat ttcataccgc atcggatagt agtcgagacc gaatccattt gcaatctcca
     4321 taatttctga tatcgcgtat tccagctctt tctggtcggt actcatccca ccgttccccc
     4381 ttcccgtttg cgaaaaaagg tgcgtagggc ttggtatacc tcaccttttt ccttgatgac
     4441 atagtacata aactgatctg ccttaatatt cttgtaggct gacatcagcg tactgctgcg
     4501 attatattgg ttcacttctc catagccgaa catattgctg cgcttcataa gctcctcgat
     4561 tagtttcaca caccgttcat tgtctgagct taggttatcg ccatcggaga aatggaaggg
     4621 ataaatatta taagtcgaag gaggatagcg tttatcgata atctccaatg ctttcaaata
     4681 agcagaagag cagattgtgc caccactttc accgcgagta aaaaattctt cctccgtaac
     4741 ctccttggct tcggtatgat gcgcaagaaa gacaatttcc accttttcat attggcgacg
     4801 caaaaagcga gtcatccaga aaaagaagct gcgggcgcaa tatttttcaa aagatcccat
     4861 gctgcctgag gtgtccatca tagctataat taccgcattg gattggggaa tggttttctc
     4921 ttcccatgtt ttgtaacgaa gatcgtccgg actaatatga tggatgcccg gattcccctc
     4981 acgagcgttg cggcgcagat tttcgagtat cgttcgcttc ttgtcaatgt tcgcttgcat
     5041 gccttttttg cgtatatcat tgaatacgat agattcaacc tcaatttgat ccttatcttt
     5101 ttgctgcaaa tgcggtaatt ccatttcctc gaacagcata tcttcgagtt cttctatgct
     5161 gacttcagtt tccataatat catgtcctgg ctggtcgcct gctttctcac ctttacctgg
     5221 cttctgggaa gcaggatcac gtccgatgac atcccccacc tgactgtcgc catccccttg
     5281 acctacatgc ttttgctttt ggtagttata aatgaagcga tattcatcca gactgcgaat
     5341 gggcactttg atgatctgtt gaccgtccga cattataata ttttcttccg ttatcagatc
     5401 gggtagattt tgcttaatga catctttgac cttctgctga tggcgttgct ggtcctggta
     5461 ccctttgcga tgcagcgacc aatcttcgcg ggatacgacg aatgaatatg gctggcgtgg
     5521 ttccgtcatt gttaggcacc ccccaagtgg atacacggca cagtttggcc ttgttggtta
     5581 ttaagtatat tcacggggat gtacgatatg tgatggaact cgatttaaat tctgcacgtt
     5641 tgcttttata atgaaagtaa aaaatgtaaa aaaagaatgg agaaccttgg ttatggaaga
     5701 aattgcagtg cttatcgtag acgatgaaca gggactgcga gatatgctga caacagtttt
     5761 aaaaaaagaa gggtttctac atgttaagca tgcagccacg ggtcaagaag cgttgcaaat
     5821 cgtgatggaa tctcgtattg atgtgattgt gcttgatgtt atgcttcctg atcgtgatgg
     5881 atttgaggtg tgtcgtcaga tgcgtctata cacggaagct cctattcttt ttttgacggc
     5941 aagagataca gatttggaca aattaatggg atttggtatt ggtggggacg attatattac
     6001 caaaccgttt aatccgttag aagtcgctgc acgtatgaaa gctcgaatga aatatcgaaa
     6061 agtgacaaca gcggacatga agcctgcctt acgaacctta gattttggat atttttgtct
     6121 ggaattggaa tcaggtgtgt tgtatgtgca agaccaagag gtcgattgtc ctgcacgtga
     6181 atggctgctg ctggtatttt tgtgcaagca tcctaaccgt atattcagtg tgcgtcagct
     6241 atacgaagca atatggagcg agaccttcct tggtgatgaa aagacagtag tcattcatat
     6301 ctctcgtttg cgaaaaaaaa tagaacctga tcccaagcac ccgcaatttt tagttaatgt
     6361 aagagggcta ggttataaaa tgatatcagt caagaggggg gagcaagaat gaactctctc
     6421 gtcaagatgt cctttcgttt tataaaagta acattatgtt ttgctctagc ctatgttctt
     6481 tgttttctta tctgtactgt tatatatatt tttataaaaa gtacatttgg tacatctcat
     6541 aatatgaata ttgatctctt ctggatcgga cttggaatcg tgcagagcct tgtgtttata
     6601 gttgtctatg gatggtatat aggcaaaccc ttggtgtatg taattaaatg gattggaaat
     6661 atagcaacag gggaattcca ggcaccgcta agtgagctag aactgccaga gcgcaaaaaa
     6721 aatcagagaa ataattataa gcctccgtat caattgtata aagaagtttt tgaacaaatg
     6781 aacatcttat ctgctcaatt gcgcagtaat gaggaagaga gaatagaaat agaaaagcga
     6841 aaacagcagt gggtagcagg cgtaagccat gatctcaaaa cgccattatc ctatattgaa
     6901 ggatatgcag ccatgctgac tactcaagag tatgattggt ccgatgaaga aaaaagaagc
     6961 tttagtatgg ctatcagtga gaaagtaacg gaaatgaagc agttaattca ggatttgaat
     7021 gcttctatgc agctcaagga gggtgccttg ccgatccagc tgaagaagga ggacattgtg
     7081 gagtttctcc gcaatacagt catagatatc gctaaccatc cttcggccga gcagtacgaa
     7141 ttttctttta tgtcattgga ggcagtatgt accatgccct tcgatagtaa attattaggt
     7201 agagcgctga aaaattttct gatgaacgca atcattcata atccttcagg tacacatatt
     7261 tcaatggatg taaataaaga gagcgataag cttcatattt cgatcgaaga tgatggaaaa
     7321 ggaatgaatc caactgaatg tatacaggtg tctcattcca aagagcatgg catatctatt
     7381 gccaaaagct ttattgaagc tcataacgga acgcttcata ttcttccggg aagtaaaaag
     7441 ggtaccaggg tggaaattac tttgccgcta aatatctaac tctttaacat ctgtgccttc
     7501 acattttgga gtccgctcgt ttttttgcct gttgtttagg agctgtttac ctgatgttaa
     7561 ctttccttct gtaaactgta tgtaactaaa acttcagcat taaaagtcga gaggagatca
     7621 ggaaatgtct gaatatgtaa tacatacaca gcagctaacc aggcgttttg gaaaacgaga
     7681 atttgtcaaa caaataaatc tccaggtacc tgagaagcaa atttacggat ttttgggacc
     7741 aaacggggcg gggaaaacaa ccacgattcg tatgctactc gggctgatta aatccacatc
     7801 cggggagatt gagatttttg ggaaaaagct caaggatcat cgcatggaaa tattaaagga
     7861 tgtaggttct ctggttgaat cacctgccta ttatgcccat ttgtctgcat atcgaaattt
     7921 ggaaatcgtt acaacaatgc gtgggctgcc gacccgaaaa attaataaag tgctggattt
     7981 ggtgagatta agcaaagatg cgtatcgacc ggtaaaagga tactccttgg ggatgaggca
     8041 aaggctagga attgccatgg cgttgattgc tgatcccaaa ttgttgattc ttgatgaacc
     8101 gacgaatggt ttggacccgt ctggtatcca ggaaattcgg gagttaatta tgagcctgcc
     8161 tgatgcttac ggaatgacgg tattggtttc gagccatcta ctaagtgaaa tcgaacagat
     8221 cgcaacctat gtagggatta ttaatcaagg ggaaatgata ttccagggaa cgatgaaaga
     8281 acttacagac aaaagcaagc ctcaattatt cattgaaacc caaaatcctg ttcaggctgc
     8341 tggagccctg atgcagcatg gatggattgc cggagctgaa tccttggagc aaaaagaggt
     8401 cataactcct attgtggatc ggcaacaatc atcggagatg atcaaagtgt tggtagagca
     8461 caatcacccc gtctatcggg taagggagaa gaaaaaaaca ttggaggaaa tattcctgga
     8521 gctgacgggt aaggagcgaa gtttatgata ctccaagtta tcaaggcgga aggatataag
     8581 ctgaaaaaaa tatgctggtg gcttcctcta atacagggct gtgtccttac agggatgact
     8641 gtcatggaat ggtatctcta ctttcgtcag gggccaggag gggtctatgc tggttttgcg
     8701 gttatgttta tgttcatctc gtttgtgatg ctgcttggcg gtacacttct agcaagtatt
     8761 atggcgggta cagagcatga tacccaaaca tggaagcagc ttatggccat gccggttccc
     8821 agaagctaca tctacttatc caaaatgttt tggattgtga ttctgcagtt tggtactgcc
     8881 ttgattacga tagcagggat gagtctcatc tgggtgctgt atacaaacga gcccattcct
     8941 tggcgagtta tgctgctgca gccgattaac gccagcttgg ctactctgcc tgtacttgca
     9001 attcaacttt ggttgtctac gctttttact aatcaggcat tcccgttagc atttggcata
     9061 tttggttcta ttgccagctt gtttttggca cgaaccagta ttctttggat taaattatta
     9121 ccttggtcgt atccggctct atcaagtcct ctaattaagg gatacgtaat gtgggtgatc
     9181 attgctttat gtgcaggggt catcttcaca ggactcggta ctctacagtt tagaaagcat
     9241 gaattcaaat aggaggagga gaagtatggg atccatttta cgcgtggaag cgatgaagct
     9301 tcaatgggtc atggtatgga ttctcattat attaagtgcg gttatcaatt ctttaatggg
     9361 agtcctggaa ctgaacgatt tgaagcagtt ttatgagcct agctggttaa tgctatacac
     9421 ctatgcggcg caatttcact cgatgttttt ttatccgctt tattgtggaa ttatcgcttc
     9481 tcttttgtgc gcatacgaac atcgagacgg gggatggaag attttattga gcagtccata
     9541 tccccgtcag cgaatctatt atgcaaaata tatattgctc attctcatcc tgtttcttga
     9601 tcagcttaca ttcatagtag gatattttgt aggtgggtat atagcaggtg ctccaggaaa
     9661 aatcccttgg ttgctcgtcc tttctaccgg atggggaggg tggttcggga ttctaccatt
     9721 ggcagccctc cagcttatgc tctcggtgaa aattcgcaat tttggagctt cactaggaat
     9781 ggctatttgc tgtgtggtgc ctaatattgt tatgacaggc tttcactctt ccataggcgc
     9841 atggtttcct tttacgattc cttattatat catgttgccg caaacagcga gctatgctcc
     9901 tagagttgag ccttatagtc ttggtttgat tgtacttttt acgtttttag cctgtctatt
     9961 tgctggaaga aagatgtttg tgaatagaga ttggctgtag ctaggatagc atgagcatgt
    10021 aatcccaggg catctctttg ttctcagaaa cacttaataa agcagaagca atcccggcga
    10081 cgccttcaag caggcctgct tttgtcagcc aggccaaaga gctgtctgcc cttggctcgg
    10141 ggtccagata tccaagtggg ctatcggctt gaaagcgatc tatcagctga ctggttaagt
    10201 gttgaataag cgggataaac gctggttcct tactgtgaca ccacattcgc caggagatcg
    10261 taagtaaccc ggcaagacca tgacacaatg cagaggagtc catttcctgc ttagtaacct
    10321 cataggtaat ggcaccgata caggccatca cagccatttt ttgcagttct tcattatgaa
    10381 gagccttccc ggcaagatat aaggaacagg caacgccggg agtaccgtaa caccaggctt
    10441 ctcttgctcg ttttaaatct aactgtaaag agcctgtttc agcttcaaaa ggaacaatat
    10501 gaggccagta gtagccgtat gtatcctcat ttttatactt aagcagccat tccgtaatcg
    10561 tttcaatcgc ttgatattgg ccttttactt caattccaga actgtaagct acagatagta
    10621 aggccaatgg tccgggaatg ccatgtgcca ttccgcaatt gaaattaccc atagcataat
    10681 tgcttttatc acgatccaaa aactggaact tttgcggaga gtaccagcct ggaacatagc
    10741 ggttgtgaat ttttatagga tatgtgagat cggttaaaaa ttgaagaata ggctcgacaa
    10801 gaggagtaca actaggatcg attgagttca tcacaatata tctcccaatc ccggaggctc
    10861 ctgaaatcgt atcaaaggat tgcatgggca tcccttcgtg cagagctaat tgtgctgtat
    10921 tcaattgcag ccattgttct gtcagaggaa tcatccattc atgtatttgc tgtaaaaaat
    10981 ggctgtagta ttcgccatga ttggaggctt ctctcacaga agaagcgatg ccggtccagc
    11041 cgctgtaaag tgagacatca ttcagacctt ttttagcaag tgaagcttga atgtgcttca
    11101 tattcaagta gattgcctga ttccaatcat acgtggagtc tgaagcacga cattgagata
    11161 gtaaaaaaat attacccgga taaccgtgtg aaagcgaagt atctccccat gggtgatatt
    11221 ttgtttcggg tgaaatattt tgctctgcgt ggactgcttt gtagaccgat tcagggttac
    11281 tcaggcgcaa ggcgattgtt gtactgaagt cttttgcctg taattgctcg catgcttcca
    11341 taacaaaatg gtccgttttc atacgaatgc ccctttcatt ttttccttca ttatattgtt
    11401 gctcaaagct ggcgagttgt ccttaaaaat tctaaaaagt aacgagggat tatcttaatt
    11461 gcattcacta aatttaagat ggatgtaaga gttttataaa gtctagttaa gattatataa
    11521 attataataa aattgtaaaa aataaaagga ggtagcaaaa tgaaaaatca atttgatctg
    11581 gacttgcaag ttgccaaaaa tgaggttgct cctaaagagg ttcaaccagc tagcggtctt
    11641 atctgtactc cttcatgtgc aacaggtact ttgaattgcc aagttagtct ttctttctgc
    11701 aaaacgtgtt aataacgaga aacaaggtac aaaaggcacg gttttataac cgtgtctttt
    11761 cccggttaaa aaataggggg aggaattatg gttggagatt tgcaggaaag gtcagttgag
    11821 atcagcaaaa atattacaca aaaactgata gacctatcat atacagaaaa aatagttcat
    11881 catagaaaca acctttcacc ttcgcgtggg acggcccctt ggaatcccgg ctggcttgct
    11941 gatggagttc caggtgtatt cgtgctgttg gccgagtggg gttatctgaa acctgatcag
    12001 aattgggcag aacatgtgca tacacagttg ttgtatttac atcgcaattc tttaatatta
    12061 ctacccgata tatctctgta ctatggttct acaggtgtag catatggaat attgcttgcc
    12121 tcaaataaca gagctaatta tcagcaactg ttaaatcaaa taaatgatta tattcgtact
    12181 caatgggtaa agtcacccgt tataaataca attacagagt tcagcaagca gatggacgtt
    12241 atccacggcc tgctcggagt gggcagatac acattagaga ttcctgaaga cgacgagaag
    12301 atgtgcaatc tgacccatca actattagat actataacgc actttatacc tgaatatata
    12361 cattcggtat caaggggaag ttcgacttcg attcatctag gaatggcgca tggcatcacc
    12421 ggaatccttg cactacttgt cactgcccta caaaaaaaga ttagagttaa aggattacat
    12481 gaggctatag aatatatagc cgattttttg cttattcaaa ttcaggagga tcaatatggt
    12541 ttgtattggc ctgtaagctc tcaagcgact tcaatgaaca agacagataa caaagaagga
    12601 atgagagaaa ttgaaggctg gtgccatgga acctgtggga tagcatggac tttattcaga
    12661 gcaggaatgg agtgtagcaa tgaagaatgg acaaagatag ctgaacaagc tatgaaatcc
    12721 gtattttgct tggatgatga gcttttaaac gcgctatccc ccactttctg tcatggattg
    12781 gcgggtttgc ttcatatggc tcatagattc tattacttca ctggtaatca agctgcatta
    12841 ggctttgccg accaaatagc attaaagttg atgaatctat acgatgaaga gctcccattt
    12901 ggttatcagg acttggaggg gacaactcat gttcataata taggaatact gcaaggggca
    12961 acaggaattg cattaagctt gttggactat ggagtaggga aggaacaacc taaatattca
    13021 gggagatgga gtgaattgtt tctaatttcg taaaagctct gtcttaactg cttatctgaa
    13081 gccgtgcttt tggggaggat tagatgaaac aaaaatttat ggttatatca tcctttaaga
    13141 agattaagca tttttttgag actttaagca ctccagaaaa cattcaaatt atgttttatg
    13201 attcgcttta ccaggctcta ccggatattg atgagcagtg catcggtgta gctttgaatc
    13261 aggatcacgt aacgctagag gatttatctc actggcacac cattaaagaa aaatttacag
    13321 tcccatttat cttcctatcc tatcattgtg atgacaaacg gcaattggat ctcctcaaac
    13381 aactgctttc catggcttca tctgaatatg ggctggaaag agatcaggag gcaattagtt
    13441 tatcacccaa tgtcattttt gatcctgctg gtaaggttat ttggaagcaa ggacatgagc
    13501 atatgctgac gatgatggaa tttcgattat tgatgtatct ccttacagcg aaagagtgtg
    13561 catccacgat tgatcacatt attgacagag tatggggagt tgatgctttt actacatcta
    13621 atacggtgta tgtgcatatc cgaaaattga gagagaaaat agaagatgat ccaagtcatc
    13681 cgaaaatact ggtaacatgc catggaatcg gttacaggtt gaatatattt cctaaaaact
    13741 tggaggtggc cagttgtgaa gagacaactg cattacactg atgctcataa cctacataga
    13801 gaaccgagag ataagaatga acgatggttc agcgcatgtg attattttct aatcagagcc
    13861 ccattactac cgttagagca atattttgag gtgttttcgg atcaagatgt agatagccat
    13921 ctttctttgg aggaaatcac tcgtcgacta aagcttgtgt cccgtgaagc tgttattcga
    13981 gaagctattt cattggcctc tccgtccctt atgcagtttc tacactactt gaacgatgac
    14041 gatgctttgg aagataaagg agagttacaa aagtatgaga agacgctaaa tagtttttat
    14101 cgttatttta ttcggatgac tactcgaacg actccatttg gattattttc aggggtgggg
    14161 caagggattt gtaaggatac tacccatttg gacataggta cctatcatca acatctgaag
    14221 agagctagac ctgacatgga atggatatat aagattatcc gaaaaatgga gtctgaccca
    14281 gtcatatttg atcaattaaa ggttttttta aaccgaacgg ttatgatcaa gggcgatcgc
    14341 gccaaattac catttcggcc taagcatgga gcggcagaaa ccgatgattc ggccgaaatg
    14401 tttagttcca ttcggcttac ggacgtcgtt cgcctgacgt ttgaagctgc tgagcatccg
    14461 attcaggtga tggagcttaa agaattacta ttgaaggcat ttcctgacgc tactacggaa
    14521 atcatcgctc attttttgca gcagcttgta gagcaagagt ttattttgag cgagcttaga
    14581 cctccactga tggatcactc accttttcat tacatatttg aaaaaattaa aaaaatggac
    14641 atgtctgatt attggactga cattttacac gaaattgata ttttattacg acaatacaat
    14701 cagtgcatga ttggagaagg agagaaggcc taccgggaac tatgtggaaa aatgctagat
    14761 atcattgctg taaaaacgcc tgtacaggtc gatgtcaaat tagctcaaga agtaacgctg
    14821 ccgagacatg tgctcgatga tgttgcatta ggagctgaag tcatgtgcag gttgttttca
    14881 tccccaaaaa tggatgaact ggacgaatat ttaaatcgtt ttttggaaaa gtacggagtg
    14941 taccaggagg tccctatcaa tgaactgttt gatgaggatt ggggacttgg tataccaaag
    15001 acgtatcgta ccaatgagaa aaaatcaatg ggcatggaag catttaaacg caacgcagtt
    15061 ctctttcaat ggctttcgaa tgccattgcc aaccatgaca tagaaatcgt tctttcagat
    15121 gagcagttgg agcagctgac gatatccgat aatgatgaca cttccccgga atctatggag
    15181 gtatactaca gtatatttgc cgaatcacct gaaaaagttg attcaggaga ctataagctt
    15241 ttacttgggc ccagcgccgg ttctaatcgg gcaggtaaaa cttttggacg ttttctggat
    15301 atgtttagtg aagagtatgt tcagaaattc tctgatattt atgatcatca ccgatgcttt
    15361 catcccgacg ccttgttggc agagatggtt tttatgcctg accagggaaa aatatcgaat
    15421 atatcactga gcaaaaattt tatggaatat gaaatcgtgt ccggaacgac ctcttctaaa
    15481 gatgaggagc agacactaca catggatgat ttattgatag gtgcaactca cgaccgtttc
    15541 tatgtcaagt ccaggcgttt gggtaaagaa atcatccccc tgcaaaccca tatgcttaat
    15601 tacaagcttt caccgcatgt attcagattc ttgaccgata tcaccaacaa agagcttggc
    15661 acatggtcat actttgactg ggggccacta gagcagtctc cttttttgcc aagacttgta
    15721 tatggaaaaa ttgttattag tgctgcgcag tggaggcttg gcaaggctgc attgaatatt
    15781 tcagatttaa ctgagcctca agcaagggag gagctttttc atacttggag agaacagtgg
    15841 aatgtgccac gctatgttta tttaacgatg ggagataacc gactgttatt ggacctgtgc
    15901 aatctcctcc atatcaaaga attgcttcgt gagatgagca agatgaggga aggacaggaa
    15961 ctgcttctta ccgagtgttt gggcgatcca ttccataccc cgctacatgg gaccgctgga
    16021 agatatatgg gggaatttgt gtttccgctc aagaagaaaa aaataaaggg gaagccgagt
    16081 attccaagtt taccccacaa gatggattct caaaaattca tggcttatac cccttcgggc
    16141 attcatagag ggttccttcc aggaggtgaa tggctgtacc ttaaattgta tggagtcaag
    16201 gaaagggaaa cggatcttat ttccttaagc ttggatcaac tccgaaataa cccggaattt
    16261 gaggattgga gtaaaaaatc ttattttttg cggtacgttg atcctgagca tcatattcgt
    16321 ctgcggtttc aaggagagcc aggtcaacta tggagtgctg gcttggcgca attaaatcag
    16381 tgggcaggtg agctgcgtga agagggactt atcacacata tggtactgga tacatacctt
    16441 cctgagttgg agaggtatgg agggcagaca cttatggacc tggcagaaca ggtttttgac
    16501 gtggatagcc gatgggttat cgcctatatg gcaggaattc gttccaaagc tttcaatctg
    16561 gacatagaga ttgcagctgt gattaacatt attcactatt taagcagctt tggtttaacg
    16621 attcaggagc aagtggactg gctagaaggt agaattgaca gcaagcctta tatgaaggcg
    16681 ttcagggata ttaaaaaagc attgattacc gctgtagaat cggaatatga atggattaga
    16741 caagcggata cggctacaca ggtcgctttg ttggcacttg tagaaaaaag acaggccatg
    16801 attcaacagt atgctcaagc gataaccctg gctgaaaaca atcatgagct tacgaatcat
    16861 gctaatgata ttttaggcag tatcattcat atgcacctga atcgtctgct gggtgtaaat
    16921 cgggaacggg aaatgaaatg tatggctttg gcaaagcata cagcggccaa cctgttgcat
    16981 cggaaaggag tgcgccatgt cacagtctaa aggacaaacc aatgacctgg tttccttgtc
    17041 ctaccaaaat atatttcgta cctttttatt ttggcctcgt atattcaggc tgctttggga
    17101 cacacaccct acttttttga tcgctatact tattacaaat ttgttgaagg gtgccgttcc
    17161 tgctgtgatc cttttagcaa cgagggaatt aattaatagt gttgtggcag gagcgtcagg
    17221 aggaagcttt cagcctgttt ttatagcttt tggtgttcta ataggtgtca atttgctgta
    17281 cgatctgatc aatattgggg aaagcttttt tcgtaaaatg tttcaaagcc ggctatcaaa
    17341 ccaggtaaat atcagaatta ttgaaaaagc acaaaagatg tctttgcagt cgtttgagga
    17401 tgcagatgtg caaaatatgc ttcaacgtgc tcagggagaa gcagattaca gaccatttga
    17461 aatatttact cagatcctcg ccattatgag cagtatggta accttatttt cgacgggtgc
    17521 tattcttatt gcgtggagat ggtgggcatt tttattcatt tttctcattc catgtttgtc
    17581 attctattcc tttttacgca ttgggcaaag agaatttaat gttcactttc aaagagcagg
    17641 aagacaacgt gaatcctggt atttgtcttt tttggtgacg agagataaca gctttaaaga
    17701 agtgaagatc tttcaactgg gagattatct gcgaaaaagg tataaaacaa tactcgaagg
    17761 gttttatcgt gaggataaag tgctggcggt tcgtagatcc tatacttctc ttgcatttca
    17821 gattgtgaat cagggtgcat gcgcatttat tattttcatg gccatacaag ccacttatgt
    17881 tggtcaaatt ttagtgggga acctggtgag cttaattcaa ggtatcacgt taacccagtc
    17941 aacgtcgcag agcattgtac aaggtatttt aagtctgtgt caaaataatt tgtatattaa
    18001 gcagcttttt gactttctgg atatgccgga ggaaacaaaa atgcaaaagt cagttcaaca
    18061 cttgcctttg tccgctatac acagtattga atttcgaaat gtatcgttta gatatcctaa
    18121 cacggaggag aatgccattt ctaatgttag ctttactctt catcaaggag agaagctagc
    18181 cattgtaggg agaaatggat cgggtaaatc aacaattgtg aagttactca ctcatctgta
    18241 ttctgatttt gaaggagaaa tcttaattaa tggacactca atacacgaat tggataaaga
    18301 cagctttagg ggaaagatag gcgtcgtttt tcaggacttt gtacattatg agatgtctgt
    18361 tagggataat ataggctttg gtcatgtggc ttccagagaa aatgatgagg ccatttgggc
    18421 agctattgat aaggcaggca ttgtagattt gatagctggt ctgccagaaa aactgaacac
    18481 tctgcttgga aaatggtttg aagatggaca acagctatct ggagggcagt ggcagcgcat
    18541 agcaatagct agggctttta tgagaaatgc tgatatctat gtgttggatg agccgagttc
    18601 ttttttagac ccacacgcag agaaggaagt ttttcaaaaa tttgatcagc ttgttcacga
    18661 gagaatagga gtatttattt cacacagatt gtcctccgca cgtatggcgg ataccattat
    18721 tttaatgaag gagggcagaa ttgtggaagc gggcagtcat aaacacttaa tggatatgga
    18781 cggagtatac gctgaaatgt tcaggctaca agcatcttcg tatctttcac aaggagaaag
    18841 tgaacttgag caagagatgc tgtcacctcc gttggtaaag gcgacaggcg gatcgtaaga
    18901 aaggacaaat cccctcctat tttaggaggg gattttctat cccaaccaca aaactcgaac
    18961 tacagccata ctcacaatac ccacaaccac agtagccagc aaatttttgc tccacaaagc
    19021 ggtcaccagc gtaggaagga ccgctataag cacttgccca ttaagagtga ccgaggtttc
    19081 agttcgtacg agcagatttt ccatgaccag tgccgtgaag atgcaaatgg ggatgtagga
    19141 cagccactgt aacacaggtt tgggcaacgt cagtttttgc agcacgacga aggggatgat
    19201 tctcggaatt gccgtgacaa tcatgccgcc gataatgata tacaggacat tgggactaat
    19261 attcatttgt cagttaacac tccaatcgtt gcggtgatca tggtcgctac aatgacggcg
    19321 atatgtgatg gcacccacca ggataaaagg tacattagaa cggccataca tagcacaagt
    19381 agcaggcgat gcttgagttt ggaggtctgg acactttgga gctgggaaat gagtagggcc
    19441 agaaacattg caggtaaggc aaagtctaga ccaaaagctt ccggctggga aatccaattc
    19501 cctagcactc caccagccac acaggaagca atccaagcga gataagctgt aatattaagt
    19561 ccgttcatcc agcggtcact gacctgcccg cctttagcca atttatccga cgctacccca
    19621 aaggattcat ccgtcaaaag gataccgatg cctatgtttt tccacagtga gtatttagaa
    19681 aagtaaggag ccaatgacgc acttaaaagc agatggcgag cattcacaat aaatgtcgtt
    19741 aaaataatga cagacggagg actggctgcc gccagcatcg agcacataat aaactgggag
    19801 gcgcctgcgt atacaagcgc tgacatcaga ccaatttcca tggtgctaac ccctgatgaa
    19861 gcgcccacaa tgccagctgc gaatccaata catacataac caagcagtgt aggaatacaa
    19921 tctttaaccc cttgtaaaac gctcagtgaa tcgggcttcg ttccgctcaa ttccgaagct
    19981 atggacatgt taaccttacc cccagtgtat aaattttata atagtatata acggaaattg
    20041 cgaagtatca atatattata caattgtatg ttatattgaa taatccctat agcgaacaag
    20101 tagttcgtaa aaaaagggcg ccccagtcag ttcatgactt atgggacaac cctaaggtgg
    20161 tggcttatat aagctcttgc cgttttttca gatatccgta gagaatcatt cccgagaccg
    20221 cgcagatggc tgcacataga ccaataactc catatcccgc ctgaagcccg cgcagtatgc
    20281 caagctcagt ggttgctccg tagactatct tgaccccttc gattacccag ccgatcacat
    20341 agttgccaat gacactacct atgcccatca gtgtgacgac gaacgtaata gctgtatcac
    20401 tgtctttcgg atatctccgt gctatgaacg ccatcacggt cggatagatc attgcaatgc
    20461 cggcacccga tgcggcaaag agaaacgcca gtctctcccc acccgcgatt gctgcaaacg
    20521 tacatatcgc tgagaaggcg gagaatagaa tcgtcgaaag tacaaacccc atccggtctg
    20581 tgagcggacc aagcaacagg cgccccaacg agaaggtaag aaaaaacgct gagagcatgc
    20641 tggacgcctt caccgtgctc catgaatacg ctttctctaa aaagttgact agccagcccc
    20701 caactgcgag ctcagagact accccaaacg acaggatcat taccatcatc cagagtgccg
    20761 gatcgcgggt tagggtcttg agtgaggtcc gttcctcatg ctgcagatcg tctcccggga
    20821 aggtgctgag cagcgcggcc acaatcggca gcaggcagag cgacaacata gccagataca
    20881 ttccccgcca gtctagcgta tgcccaaata ccgtcagtga catgactccc gtcgccagca
    20941 aaggggcgac tgttgagcta agcccataga aaaagtgaga caaattcatc atcgtgccgg
    21001 tatttttcac aaaaatcctc gcccccaaaa ttgcgagtgc aatctccagc atgccgttcc
    21061 cgatatacat caagaagtag gacgaagcga agaacggata cgtgtgcgac aggtagatga
    21121 acactcccga gatgatcatg gaagcaaaag aaatgatgct gaccgccttg attccccact
    21181 ttcggacaag gacagcggtg aacgagcagg caatcaaata accaagtgcg tttagagaca
    21241 acaatgttcc gagctgctgt tcatccatat tgaagtcgaa ttgaatgcgt ggaatggcag
    21301 gaccttttat attctccgag ataccaaata caataaagcc aataaaaatt gtcgccagct
    21361 gcatcatgta catgtggcgg gacttgcggg tttgcggatt caaatttagt ccctcctaga
    21421 tagtcaacgt tgattctctc gcctgttggg tgttcaggga tggaaaagtc acaggatagc
    21481 ggcccccttc aggatattac aatagttttg aaaaacgttt tagtaagtga agtttaagga
    21541 catttatagt taatgtcaac agtaaattat agctacagcg gacacttttg tgtattcttc
    21601 atatatagac tttgggatac gaggaggtat aattcggtgg attcaatgca atatattatt
    21661 ggttctaatt tggctcaaat taggaaaact agaggactta gtttggataa ggtggctgaa
    21721 ctgacagggg ttagcaaagg gatgctggct caaattgaga aggggaaatc taatcctacg
    21781 gtaaccacac tttggaagat tgcgaacggc ttgcacgtat ccttttcgac ctttcttaaa
    21841 gaagacccgc cgcaaatcac gaagattcgt agagcagatc tgcatccagt tattgatgag
    21901 gacggtaact attttgttta ccctgtcttc ccgtatcact cggaaaagaa gttcgaggta
    21961 ttcacggtaa gtctgaagcc aggctttaca cacaaggcag aagagcatct gggagaggaa
    22021 acgatcctca tgatccgtgg ggaaatgtac tttgaaatgc aggggcaaca gctccgattg
    22081 agtgcagggg acgccgtaca atttcaagga tctgatatcc atacctatcg taatgattcg
    22141 gatgaggatg ccgattttta tgtattgatt tattatgcgg attagtggga tgattaatat
    22201 agtctacaac agacttccac acaggattct gcaaaatcct gagatataaa aagagagcaa
    22261 cgaggaaaag agaggaaaga acccatggaa agcaagtaca tccgagaaac ctactgcttt
    22321 aagacgtccc gagtatttcc caacgatatc aacaatcata acacgctctt tggaggccga
    22381 ttgatgtcat atatcgacga tatcgcatct attgctgccg ccaagctgtg ccgtacgaac
    22441 acagtaacag cctcgacgga ttcggtagat tttttgctgc ctatccaccc gagcgattct
    22501 gtcacgctgg aagcgttcgt aacttggaca ggccgcagct cgatggaggt gttcgtaaaa
    22561 gtgattcgcg agggattgat gactggtgat cgcaaaattg cagctaccgc cttcctgacc
    22621 tttgtggcat tggacgagaa caatcgtaaa gtgaccgtcc cacaggtgat tccggaaaca
    22681 gaggagcaaa tacaattaca ccagacggct ccatcgcgcg cagccatacg gcgtcagcgg
    22741 agggaagaaa gcaagcagct ggctagtttt ctgacgacag attttccgtg ggaagtgtag
    22801 tgtactagac atcacccatt ttaccgtttt agcataaaaa ggagccgttt tccgttagag
    22861 atcactacga tctgttcgga tgacggctcc ttttgataag gatctgagct attccacttt
    22921 gactacacgg aaatgctggt tcgtcccgcc attatcgccc cattgaatgg ctttggctcc
    22981 atcggcagtg gcaccttcgg aaatgtcgat tagcttgccc gttgcccgat ttttcagctt
    23041 gtaatagcct ccggttacgg atacgagctg ccaatgctgg ctggaccagc ctccatcatt
    23101 ccactgttca ataactgcgc cgtctgctgt agcaccgctt tcaacaccaa tcagcttccc
    23161 gctgttccga ttcacaattt tataatatcc gccgcctgca tccttaagct gccattgctg
    23221 gcttggcgct ccggaattcg cacgctgctc taaatctgct ccgtctgtcg tcgcattgcc
    23281 aatgatgcct agcggcttgt tgctcttgcg gcttaccagc tgataataag catccgggtc
    23341 gatgaccatc ggcgtagtta cgccctcaac tacaccactg gcggtatcaa tgctgatgct
    23401 gtcgaaccaa tccatagcta atgaggtcgc ggttggaaaa cgcagcggca gccatacata
    23461 ttgagaatcc tgcacaggac cgctccacgc cccagcccaa cggtcgccca aatacagata
    23521 cgaggtcgtc tgcgtacctt caacaggaat gacgtaagcc gactgtgaac cataggttgt
    23581 actatccccg aagttcatcg tattgctcca ggttccttca atgctcgatg cggtagcata
    23641 cttggcctga ttgggattcc agccggttgc cccggatgta atcaggaagt agacgtctcc
    23701 ttttttgaac atcgctggag cttcacgata ttgtcctggc caaagtgtag tcaccagcga
    23761 ttcaacttga aggaaatccg gtgtcagacg ataaatgttc agatccgcgt ttacacgggt
    23821 agccgaaatc aggtatgcag taccgttatc gttgtatacg gtcatatcgc gcgaatcata
    23881 atccagcgga cggaagctgc cctgatacgt ataatctccg tctacagtat cggatgaggc
    23941 aactgccact cgggcttcgt tgtaattaat cccgttttcc ttgtgcatcc ataatacgta
    24001 tttgcgtgtt ttttcgttat aaatcacttt cggacgttca atattcgata cattcagctc
    24061 tgcggccgaa ctgctggtca gcacgttttt acgaaactcc caatttttta aatcagagga
    24121 acgataggcg gagaccgcct tgaatgttcc attcggatta cgattttcac caaaccaata
    24181 ataataaccg tccactttaa tcatcccgcc cccatgggca tggaccacgt ttccatctgt
    24241 atctttaaac tgaatgccat ttactacatt cgctgaagca gctgaagcga tcttaggtga
    24301 aaacatctga aaaatgctta acgaaagcaa aatagtgagc ataatacaca gcaagcgggc
    24361 aaaatcatat ttcattgttt cgtcctcctc tgtatggtta ttttaaagcg ctttcattaa
    24421 tagggtctat gaagtagttt tgatagagct gcttatccca attgtatcca tattgaattg
    24481 aaagtgctag agtagtatat tgaccatgta tatggcaagt gtcatcctaa tttaacagac
    24541 ttcaatcgac tggtgagtgt tacaaactgg ctaatatcca ttaggtatac aggaggcgac
    24601 catggaaata tacgcgattg atacaagcaa gccggaggct gaggaacatt atgaattact
    24661 ggtaaatcag gtttcactgg aaaaacagca caagttggat cgttttttac atcgagaaga
    24721 cgctttgagg gggttatacg ccgatgtgct gttaaggtgg ttggtttgtc ggcaattaaa
    24781 aataccaaat gccagccttc agtttacata caatgctttt ggcaagccct ccttgttgaa
    24841 tgcgccggca ttccatttta atgtttccca ttcgggaaaa tgggtagtat gcgccattga
    24901 tgatcatccg cttggtattg acattgaaca gctccgtcct attgattttg aggtaggcag
    24961 ggtatgcttt tcagacacag agtacgatgc attaatgcag caggatgcag agagtcgttt
    25021 agactatttt tacgatcttt ggacgcttaa ggaaagtttt gtgaaggccg aagggcaggg
    25081 gctgacgcta ccgttaaagt ctttttcatt cgagttggaa gcacgaccgt ctataggttt
    25141 cacgacagag ggttttacta cagagtattg tcactttaag caatataatg agctagaccc
    25201 agattataaa atggctgtct gtgcagctca tgatcacttt gcgcaggagg tacagcaggt
    25261 agatataaat acactacgtt tggaagtggc aaccttggcg taatatgcag cagatcaagc
    25321 atatagttgg agaaaaggag atgagtggcg ttgacattcg ttttgttcaa gcgcggcagg
    25381 ttatatgggg actgggcttc caaaggagac tccatcgttg tacagcatgg ccgcatacag
    25441 gccattggat atgcccggga gcttgaattg cagttgtcag gtaaggagta cgagacggtg
    25501 gattgggagg gtgccaatgt actgccgggc ttaactgatg cccatatgca tttgtctatg
    25561 catggtatga agctggctat gctggatttc acatcagcta cttccaagga cgagatgctg
    25621 gctatgctgc gcaagcgggt cgctgtaaca ccgccgggag agtggatttt aggtcttaat
    25681 tggaacgaaa acgcgtttat tcctgttgaa attccaaata tagctgagct ggatgccatt
    25741 acagatcagc acccggtata tctgactcgt acgtgctttc atacgttttt ggccaattca
    25801 gaggcatttc ggcgtgcagg tattcacgag aacacccctg atccggcttc aggagcctat
    25861 ggacgagacg cagagggacg gttaaatgga ttgatttatg aggaagcatc ctttgccttt
    25921 acaagcgtgc agccagagcc ggattattcg gcgaagaagg atacgatccg gcgggcttgt
    25981 ctggatgcgc tacggctggg tctgactgct gcacacacgg aggatttacg ttttttgggc
    26041 agcgtagaga cgatgcagcg aatttacaag gagctgagag aagaaggtct tgcttttcgc
    26101 acacaccagc tcatctatca tccatttatg gaagaagtga aagtacagga gctccgtgca
    26161 ggtaccggaa atgagtggtt caaaatcggt gcaattaaaa tatttgctga cggcgctatt
    26221 ggtggaagaa cggctttatt atccgaacct tatagtgatg ctccacatac gtgtggaatg
    26281 gccatccaac cacagccaga gctgaatcag atggtggcag cagccagagc cgcaggcttt
    26341 ccagtggctg tacatgccat cggagatggg gcggcgcaca tgattttgac agcgatggag
    26401 gcccatggac taacggagga aagcgggttg ccggatcgtc tgattcatgg gcaggtgcta
    26461 cgggctgatt tggttaaaag aatggcgaag ctgccgctga ttgcagacat ccagcctcgt
    26521 tttgtcgcaa gtgattttcc ctgggtgctg gatcgggttg ggaaagaacg gaccgagtat
    26581 ttatatgcct ggaaaaagct gctgcaagca ggcattccgt gtgctggagg cagtgatgcg
    26641 ccgatcgagc ccctaaaccc atttctgggt atacatgcgg cagtgactcg cgccaagccg
    26701 gaagaaatgc atgagggcta tcttcccgct gagaagctgg atgttcacga agccattcat
    26761 ctgtttacta tgggaagcgc agtagcggct ggggaagctg atgaaagagg gacaatcgct
    26821 gaaggcaaag ccgctgactt taccgttatt gaccgcgatg tatcggaaag tcaccaggct
    26881 ttgcttgatg ttaaggtacg aatgaccgtt gtgaacgggc aagttgcata ccagtcgtag
    26941 gctggtaata cgtatgtatg gcaaaagcct tcaccttcac tttttacgtg aggttgaagg
    27001 cttttgaatt
//
