LOCUS       NZ_JAJOZU010000004     10822 bp    DNA     linear   CON 08-AUG-2024
DEFINITION  Thermomonas alba strain SYSU G04536
            NODE_4_length_354697_cov_193.971264, whole genome shotgun sequence.
ACCESSION   NZ_JAJOZU010000004
VERSION     NZ_JAJOZU010000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Thermomonas alba
  ORGANISM  Thermomonas alba
            Bacteria; Pseudomonadota; Gammaproteobacteria; Lysobacterales;
            Lysobacteraceae; Thermomonas.
REFERENCE   1  (bases 1 to 354697)
  AUTHORS   Liu,Z., Jiao,J. and Li,W.
  TITLE     Thermomonas sp. nov., a bacterium isolated from hot spring
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 354697)
  AUTHORS   Liu,Z., Jiao,J. and Li,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-DEC-2021) College of Life Sciences, Sun Yat-sen
            University, NO. 135, Xingangxi Road, Guangzhou, Guangdong 510275,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022419205.1-RS_2024_08_08
            Annotation Date                   :: 08/08/2024 03:47:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,368
            CDSs (total)                      :: 2,315
            Genes (coding)                    :: 2,258
            CDSs (with protein)               :: 2,258
            Genes (RNA)                       :: 53
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 45
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 5 of 57
            Pseudo Genes (incomplete)         :: 51 of 57
            Pseudo Genes (internal stop)      :: 2 of 57
            Pseudo Genes (multiple problems)  :: 1 of 57
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:42:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 219703
            Orig. end                         :: 230525
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAJOZU010000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10822
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10822
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10822
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5822](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5822
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(252..266)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.31"
                     /tool="antismash"
     misc_feature    complement(653..664)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            1031..1999
                     /gene="pstC"
                     /locus_tag="ML342_RS07965"
     CDS             1031..1999
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pstC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018974334.1"
                     /locus_tag="ML342_RS07965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="WP_240126510.1"
                     /transl_table=11
                     /translation="MNATSDSLDLTPRERADLRTDTRFRWLVTTAGMLVLISLVAAALS
                     MLWGGRLAFHKFGLAFLWTDQWDAVQQQFGALVPIYGTVVTAAIAMLIAVPVSFGIAFF
                     LTEIAPRWLRAPIGAAVELLAGIPSIIYGMWGLFVLAPLLGEHVFPWVDEHLGQLPGIG
                     VLFSGPPLGLGMGTAGLVLAIMVIPFVSSVMREVFLTVPGPLKESAYALGATRWEVVWD
                     VVLPYTRSAVIGGIFLGLGRALGETMAVTFVLGNAHALTYSLLEPGNSIAATIANEFTE
                     ADSKMYLSALIALGFVLFMLTFVVLTLARLMLRRLNRQEGR"
     gene            1999..2853
                     /gene="pstA"
                     /locus_tag="ML342_RS07970"
     CDS             1999..2853
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pstA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003487152.1"
                     /locus_tag="ML342_RS07970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="WP_240126511.1"
                     /transl_table=11
                     /translation="MFPSLHGWRAFKNILAQLLATLATLFGLFWLIWIMWTTLRTGISA
                     ISPALFTQMTPPPGEEGGGLLNAFFGSAVISLMGIAIGAPIGVLAGTYLAEYANRHWLG
                     EAVRFINDILLSAPSIVLGLFVYTLVVAQMGHFSALAGGIALAFIVLPVVVRTTDEMLR
                     LVPVQMREAALSLGVPQWKMILQVLYRSALPGIVTGILLALARISGETAPLLFTALNNQ
                     YWTTDLLAPMANVPVVIFQFAMSPYDGWHALAWAGAFILTLFVLAISLIARAIVLRNKM
                     THD"
     gene            2846..3679
                     /gene="pstB"
                     /locus_tag="ML342_RS07975"
     CDS             2846..3679
                     /EC_number="7.3.2.1"
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0015415 - ATPase-coupled phosphate ion
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pstB"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019237787.1"
                     /locus_tag="ML342_RS07975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphate ABC transporter ATP-binding protein
                     PstB"
                     /protein_id="WP_240126512.1"
                     /transl_table=11
                     /translation="MTDLRTIPMPSTHATAMPAEHTAAAAPPPKIAARGLNFWYDKFHA
                     VKNINLDVPEKHVTALIGPSGCGKSTLLRVFNRIYALYPKLRAEGEVLLDGDNVLDPKY
                     PINRLRSKVGMVFQKPVPFPMTIYENVAYAIRHHERLSRSELDDRVEQALRQAALWDEV
                     KDKLKASGLSLSGGQQQRLCIARAVALRPEVLLLDEPTSALDPISTSRIEQLVEELKQS
                     FTIMIVTHNMQQAARVSDYTAFMYLGDLVEYGPTAQIFSTPAKQQTEDYITGRFG"
     gene            3742..4446
                     /gene="phoU"
                     /locus_tag="ML342_RS07980"
     CDS             3742..4446
                     /GO_process="GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0030643 - intracellular phosphate ion
                     homeostasis [Evidence IEA]"
                     /GO_process="GO:0045936 - negative regulation of phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="phoU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008265615.1"
                     /locus_tag="ML342_RS07980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="WP_240126513.1"
                     /transl_table=11
                     /translation="MNEQGSHIVRSYDKEQAALLDELIRMGNMAVAQLEAALDVVERRD
                     GNAAERVIANDEAIDALEHQVNHDVIHLIRRGPLASDLRIILAALRVASDIERIGDYAA
                     NIAKRSLALNLAPPLPHTRGLTALGKLAVQQARDVLEAYRQRDEDAALRVRQRDAELDT
                     LYTGLFRELLTYMMEDPRAITPCTHLLFMAKNLERVGDHATNIAENIWFLRHGEAPLPE
                     REKRDESNTVAP"
     misc_feature    4535..4545
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            4539..4994
                     /locus_tag="ML342_RS07985"
     CDS             4539..4994
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010483445.1"
                     /locus_tag="ML342_RS07985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_240126514.1"
                     /transl_table=11
                     /translation="MSQIHKPLSVLLGAAVATGTLAAGSLFSMDAMAHGYMQDAGKSAA
                     GKAGEGKCGGEGKCGAGKMAAAKADHEGGCGMAKMDTDKDGRISRAEFNATHKGQDAMF
                     AKIDTNGDGFISQAEMDAHHAAMQKDARPAAKAASEGKCGEGKCGSM"
     gene            5001..5822
                     /locus_tag="ML342_RS07990"
     CDS             5001..5822
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014646321.1"
                     /locus_tag="ML342_RS07990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_240126515.1"
                     /sec_met_domain="DUF692 (E-value: 4.4e-115, bitscore:
                     377.9, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATLPAHSAGLGLRRALLDELIEAPAGAFDFLECAPDNWIGVGG
                     ALGERLARLSARHPLSCHGLSLSLGGPDPLDLELLRQTRAFLDRHRAVLYSEHLSYCAA
                     GGHLYDLLPLPFTEEAVRHVAARIRQAQDVLGRRIAIENVSTYAIPAAEMDEATFVRAV
                     LEDADCDLLLDVNNVYVNAANHGFDAHAYIAAMPAARIVAYHVAGHYDEPDGLKIDTHG
                     TAVKDAVWELLGFAYATHGVRPTLLERDFHFPPLPVLLDEVARIRALQAAA"
     gene            5819..6565
                     /locus_tag="ML342_RS07995"
     CDS             5819..6565
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009598434.1"
                     /locus_tag="ML342_RS07995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2063 domain-containing protein"
                     /protein_id="WP_240126516.1"
                     /transl_table=11
                     /translation="MSALRDQLHALAAHVRDPAFHPGPPGIPERRLRVYRELVFNNLGG
                     LLAGTFPVIRRTLGDDAWRDLLRRFLATHRSQTPLFTRLGLEFVAFLAHIDDPARPWLA
                     ELADYEWAELGLQLSQAAAPATDAMADLLDGRPALSPLAWPRAYRWPVHRIGPDFQPGA
                     PPPQPTLLLLRRDAGGRVHFSQLSPLLYRLLELADGNTDRSGRALLLQLAAEAGHADIA
                     AFQQEALPMLARLQQEGVLYWHPQVT"
     gene            complement(6720..7511)
                     /locus_tag="ML342_RS08000"
     CDS             complement(6720..7511)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017158091.1"
                     /locus_tag="ML342_RS08000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_240126517.1"
                     /transl_table=11
                     /translation="MLELWQTLSALGSGAAVGFVLGLIGGGGSILATPLLLYVVGIAQP
                     HVAIGTGALAVSANAYLNFAGHARRRNVCWACAIVFALVGTVGALLGSTLGKAMDGQRL
                     LFLFGLIMVAVGVAMLRPRRERGAAHPITNLRHCLRTGVAALLAGGASGFFGIGGGFLI
                     VPALIWATGMSMANAVGSSLLAVGTFGLATALNYALSGMVNWPVAGLFIAGGLLGGMAG
                     TRLSLRLASQRNTLTRIFAGVVFVVAAYILYRSGSALRLAG"
     gene            complement(7517..7876)
                     /locus_tag="ML342_RS08005"
     CDS             complement(7517..7876)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01244.1"
                     /locus_tag="ML342_RS08005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR01244 family sulfur transferase"
                     /protein_id="WP_240126518.1"
                     /transl_table=11
                     /translation="MPAITPITPITPITPTYHVSPQLDPREVAAIAAAGYRTLVCMRPD
                     GEAFGQPAWAAVEAEAKKHGLQTHYIPAQSGAVTPAQAAQLKQVLAQAPGKVLAYCASG
                     NRCALAYQMARQLPD"
     gene            complement(7916..8809)
                     /locus_tag="ML342_RS08010"
     CDS             complement(7916..8809)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016902486.1"
                     /locus_tag="ML342_RS08010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_240126519.1"
                     /transl_table=11
                     /translation="MDIPPVPAPSSAHPEVTAFFDPATNTISYVVRDPASTACAIIDPV
                     LDFDPAAGRITYASAQRIVDHVRAQGLQVEWLIETHVHADHLSAAPWLQQQLGGRIGIG
                     EKIVEVQRTFGKVFNEGTEFRRDGSQFDHLFADGERYAIGTLEAFALHTPGHTPACMTH
                     VVGDAAFVGDTLFMPDAGTARADFPGGDARTLYRSARRILALPPQTRLFMCHDYGPNGR
                     EIRWQTSVAEERQSNIHVADGSDEDAFVAMRQARDATLGMPRLILPSLQVNMRAGHLPP
                     PDGDGRHFLKLPLNAL"
     gene            8943..9878
                     /locus_tag="ML342_RS08015"
     CDS             8943..9878
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="ML342_RS08015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydrogen peroxide-inducible genes activator"
                     /protein_id="WP_240126520.1"
                     /transl_table=11
                     /translation="MPALPNLRHLRYLVALHDHLNFSRAAEACFVTQSTLSAGIRELEA
                     QLGAAVAERNRRTVVITPLGHRLVAQARTLLREAEALMAMAAEDGNPMAGLLELGVLPT
                     IGPFLLPRLIPALGQAFPQLRLTLREDHSGNLLDQLAQGRLDLVLMAFPYDTPGMETFP
                     LFADAYRFVGPARDASASPPGGRVPLAAQLEGRHLLLLEHDHCLHGQAMPALQQAADGG
                     RINFASTSLHTLVAMVAAGMGATFLPDLAITGGILRGLPVVVQPLDVAEGQRTIGLCWR
                     RHAARRETFLALGGFLRTWAARAIQPWTPD"
     gene            9913..10596
                     /gene="rnt"
                     /locus_tag="ML342_RS08020"
     CDS             9913..10596
                     /GO_function="GO:0016896 - RNA exonuclease activity,
                     producing 5'-phosphomonoesters [Evidence IEA]"
                     /GO_process="GO:0006364 - rRNA processing [Evidence IEA]"
                     /GO_process="GO:0042780 - tRNA 3'-end processing [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rnt"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003467237.1"
                     /locus_tag="ML342_RS08020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribonuclease T"
                     /protein_id="WP_240126521.1"
                     /transl_table=11
                     /translation="MTDLMDARADTPAFAPMAQRFRGYLPVVVDVETGGFDCQRHALLE
                     IAAVPIELDAAGRYVPGEVAHAHIAPAPGTEIDPKSLEVTGIKIGHPLRGELPEREGLD
                     AVFIPVRAAVKRHGCQRAILVGHNAHFDLGFLNAAVARVQHKRNPFHPFSVFDTVTLAG
                     LAYGQTVLARAAMAAGLGWDPKEAHSAVYDALQTARLFCAIANAWPLPTAGNAGAAAEP
                     ADGAA"
     misc_feature    10662..10677
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.15"
                     /tool="antismash"
ORIGIN
        1 cgcccagatc aaggccgcga ccgtggattt cggcgcctcc gacaagccgc tctcggccga
       61 agagctgaag caggccggcc tggcgcagtt cccgctggtg atcggcggca tcgtgccggt
      121 ggtgaacgtg ccgggcgtgg ccccgggtgc gatgaagatc gacggcacgc tgctggccga
      181 catctacctg ggcaagatca ccaagtggaa cgacccgcgc atcgccgcgc tgaatccggg
      241 cctgaagctg ccggacatga agatcaccgt ggtgcaccgc tccgacggct cgggcaccac
      301 cttcaacttc accaactacc tgtccaaggt cagcccggag tggaagcaga aggtcggtga
      361 gggcacctcg gtggcgtggc cggtcggcgt cggcggcaag ggcaacgaag gcgtggcggc
      421 ttatacccgc cagatccgcg gcggtatcgg ctacgtggaa tatgcctatg ccctgcagaa
      481 caagctgacg tatgcactga tgaagaatgc cgccggcaac ttcgtgcgtc ccagcgacga
      541 gaccttccag gccgccgcgg ccagcgccaa ctggggagcc gtcaaggatt tcaacctgat
      601 catgaccaat gccccgggtg ccaacgcctg gccgatcacg gccacgacct gggcgatcat
      661 gtacaagaag cccaaggatg ccgcgcgcac ccgtcaggcg ctggccttct tcaagtgggc
      721 gctggaaaac ggccagccgc aggccgcggc gctggactac gtgccgctgc ccgcctcgct
      781 ggtgcagcag atcgagacct actgggcgca gaacatcgcc agcaagtaat ccctgcagca
      841 ggctgtagcc aggcgggccc ctcgggcccg ccttttttca tttcgatcca tgtcacgaag
      901 ctgtcataaa accatcgttt catacccact ctgcaccgat cttcccgaca cctccgcaca
      961 cgcccaaccc cgtctgccgg gtgaggcacg cacgcgtgcc cacgccccca gcagagccca
     1021 agtcactgcg atgaacgcca catccgacag tctcgatctg acgccgcgcg aacgcgccga
     1081 cctgcgcacc gacacccgtt tccgctggct ggtgaccacc gccggcatgc tggtgttgat
     1141 cagcctggtc gccgccgcgc tgtcgatgct gtggggcggg cgcctggcct tccacaagtt
     1201 cggtctggcc ttcctctgga cagatcaatg ggatgcggta cagcaacagt tcggcgccct
     1261 ggtgccgatc tacggcaccg tggtcaccgc cgccatcgcc atgctgatcg ccgtgccggt
     1321 cagtttcggc atcgccttct tcctgaccga aatcgccccg cgctggctgc gcgcgccgat
     1381 cggcgcagcg gtggaactgc tggcgggcat tccctcgatc atctatggca tgtggggcct
     1441 gttcgtgctg gccccgctgc tgggcgaaca cgtgttcccg tgggtggatg aacacctcgg
     1501 ccagctgccc ggcatcggtg tgctgttcag cggtccgccg ctggggctgg gcatgggcac
     1561 cgcggggctg gtgctggcca tcatggtgat ccccttcgtc tcctcggtga tgcgcgaggt
     1621 gttcctcacc gtgccggggc cgctcaagga atccgcctac gcgctcggcg cgacccgctg
     1681 ggaagtggtc tgggacgtgg tgctgcccta cacccgctcg gcggtgatcg gcggcatctt
     1741 cctcggcctc gggcgcgcgc tgggcgagac gatggcggtg accttcgtgc tcggcaacgc
     1801 gcatgcgctc acttactcac tgctggagcc gggcaactcg atcgccgcca ccatcgccaa
     1861 cgagttcacc gaagccgatt ccaagatgta cctgtccgcg ctgatcgcgc tcggcttcgt
     1921 gctgttcatg ctgaccttcg ttgtactcac gctggcacgc ctgatgctgc gacgactcaa
     1981 ccgccaggag ggccgctgat gtttccgtcc ctgcacggct ggcgcgcgtt caagaacatc
     2041 ctcgcccagc ttctcgcgac gctcgccacc ctgttcggcc tgttctggct gatctggatc
     2101 atgtggacca cgctgcgcac gggcatcagc gcaatcagcc cggcgctgtt cacccagatg
     2161 acgcccccgc ccggcgagga gggcggcggc ctgctcaacg ccttcttcgg cagcgccgta
     2221 atcagcctga tgggcatcgc catcggcgcg ccgatcggcg tcctggccgg cacctacctg
     2281 gccgaatacg ccaaccgcca ctggctgggc gaggccgtgc gtttcatcaa cgacattttg
     2341 ctatcggcgc cttcgatcgt gcttggcctg ttcgtgtaca ccctggtggt ggcgcagatg
     2401 ggccacttct cggcgctggc gggcggcatc gccctggcct tcatcgtgct gccggtagtg
     2461 gtgcgcacca ccgacgagat gctgcgcctg gtgccggtgc agatgcgcga ggccgcgctg
     2521 tcgctgggtg tgccgcagtg gaagatgatc ctgcaggtgc tctaccgcag cgctctgccc
     2581 gggatcgtca ccggcatcct gctggcgctg gcgcgcatca gcggcgaaac cgccccgctg
     2641 ctgttcaccg cgctcaacaa tcagtactgg accaccgacc tactggcacc gatggccaac
     2701 gtgccggtgg tgatcttcca gttcgccatg agcccctacg acggctggca cgcgctggcc
     2761 tgggccggcg ccttcatcct caccctgttc gtgctggcga tcagcctgat cgcgcgggcg
     2821 atcgtgctgc gcaacaaaat gacccatgac tgacctgcgg accattccaa tgccctccac
     2881 gcacgccacg gccatgcccg ccgagcacac cgccgccgca gcgcctccgc ctaagatcgc
     2941 cgcgcgcggc ctgaacttct ggtacgacaa gttccacgcg gtcaagaaca tcaatctcga
     3001 cgtgccggag aagcacgtca ccgcgctgat tggcccgtcc ggctgcggca aatccaccct
     3061 gctgcgcgtg ttcaaccgca tctacgcgct ttatcccaag ctgcgcgccg aaggcgaggt
     3121 gctgctggac ggcgacaacg tgctcgatcc gaagtacccg atcaaccgcc tgcgtagcaa
     3181 ggtcggcatg gtgttccaga agccggtgcc gttcccgatg acgatctacg agaacgtggc
     3241 ctacgccatc cgccatcatg agcgactgtc acgctcggag ctggacgacc gggtagaaca
     3301 ggcgctgcgc caggccgcgc tgtgggacga agtgaaggac aagctgaagg ccagcggcct
     3361 gagcctgtcc ggcggccagc agcaacgcct gtgcatcgcg cgcgcggttg ccctgcgccc
     3421 ggaggtgctg ctgctggacg agccgacctc ggcgctggac ccgatctcca ccagccgcat
     3481 cgaacagctg gtggaagagc tcaagcagag cttcaccatc atgatcgtca cccacaacat
     3541 gcagcaggcg gcgcgcgtgt cggattacac cgccttcatg tatctcgggg atctggtcga
     3601 atacggcccg accgcgcaga ttttctcgac ccctgccaag cagcagaccg aggactacat
     3661 caccggccgc ttcggctgag cacgcttgac ccataccccg acgacgatgc gcccctccac
     3721 cagcgggcca ggagcacacc catgaacgaa caaggcagcc atatcgtccg tagctacgac
     3781 aaagagcagg ccgccctgct cgatgagctg atccggatgg gcaacatggc ggtcgcccag
     3841 ctggaagcgg cgctggacgt ggtcgaacgc cgcgatggca atgccgccga gcgcgtgatc
     3901 gccaacgacg aggcgatcga cgcgctggag catcaggtca accacgacgt gatccacctg
     3961 atccgacgcg gcccgctcgc gtccgacctg cgcatcatcc tcgccgcgct gcgcgtggcc
     4021 tccgacatcg agcggatcgg cgactacgcc gccaacatcg ccaagcgctc gctggcgctg
     4081 aatctggccc cgccactgcc gcacacgcgc ggcctgaccg cgctcggcaa gctggcggtg
     4141 cagcaggcgc gcgacgtgct ggaggcctac cgtcagcgcg atgaggacgc cgcgctgcgg
     4201 gtgcgtcagc gcgatgcgga actggacacc ctctacaccg ggctgttccg cgagcttttg
     4261 acctacatga tggaagaccc gcgcgcgatc accccgtgca cccacctgct gttcatggcc
     4321 aagaacctgg agcgggtcgg cgatcacgcc accaacatcg ccgagaacat ctggttcctg
     4381 cgccacggcg aggcgccgct gccagagcgt gagaagcgcg atgagagcaa caccgtcgcg
     4441 ccgtgaccgt gcgcggcgcg cccctgcact ggcgccgcgg ccgccagcag cgctaggatc
     4501 ggaagcctgt cgatcccgtg cctcatcagg agcctgccat gtcccagatc cataaaccgc
     4561 tgtcggtgct gctcggcgcc gccgttgcca ccggcaccct cgccgccggt tccctgttct
     4621 cgatggacgc gatggcgcat ggctacatgc aggacgccgg caagtccgcc gccggcaagg
     4681 ccggggaagg caagtgcggc ggcgagggca agtgtggcgc cggcaagatg gcggccgcca
     4741 aggccgacca cgagggcggc tgcggcatgg ccaagatgga caccgacaag gacggccgca
     4801 tctcgcgcgc cgagttcaat gccacgcaca aaggccagga cgcgatgttc gccaagatcg
     4861 acaccaacgg cgacggcttc attagccagg ccgagatgga cgcccatcat gccgccatgc
     4921 agaaagacgc caggcccgcg gccaaggccg ccagcgaggg caagtgcggc gaaggcaaat
     4981 gcggcagcat gtgagccggc atgtccgcca cgctgcccgc gcatagcgcc ggcctcggcc
     5041 tgcgccgcgc cctgctggac gaactgatcg aggcgcctgc gggcgccttc gatttcctgg
     5101 aatgcgcccc cgacaactgg atcggcgtcg gcggcgcgct gggcgagcgg ctggcccggc
     5161 tttcggcgcg ccatccgctg agctgccacg gcctgtcgct ctcgctgggc gggccggatc
     5221 cgctggatct tgaactgctg cgccagaccc gcgcgttcct cgaccgccat cgcgcggtgc
     5281 tctacagcga acacctgagc tactgcgcgg ccggcggcca cctctacgac ctgctgccgc
     5341 tgcccttcac cgaggaggcg gtgcgccacg tcgccgcccg catccgccag gcgcaggacg
     5401 tgctcgggcg ccggatcgcg atcgagaacg tgagcaccta tgcgattcca gccgcggaga
     5461 tggacgaggc gacgttcgtg cgcgcggtgc tggaagacgc cgactgcgac ctgctgctgg
     5521 acgtgaacaa cgtgtacgtg aacgcggcca atcacggctt cgatgcgcac gcctacatcg
     5581 ccgcgatgcc tgcggcgcgc atcgtcgcgt atcacgtcgc tgggcactac gacgaacccg
     5641 acggcctgaa gatcgacacc cacggcacag ccgtgaagga cgccgtgtgg gaactgctcg
     5701 gcttcgccta tgccacccac ggcgtgcgcc ccaccctgct ggagcgcgac ttccatttcc
     5761 cgccgctgcc cgtgctgctg gacgaggtgg cgcggatccg cgcgctgcag gcggcggcat
     5821 gagcgcgctg cgcgaccagc tgcacgcgct ggcggcgcac gtgcgcgacc cggcgttcca
     5881 ccctggcccg cccgggatcc ccgagcgccg gctgcgggtg taccgcgagc tggtgttcaa
     5941 caacctcggc ggcctgctgg ccggcacctt cccggtgatc cgcaggacgc tgggcgacga
     6001 tgcgtggcgg gacctgctgc ggcgcttcct cgccacccat cgcagccaga cgccgctgtt
     6061 cacccgtctc gggctggagt tcgtcgcctt cctcgcgcac atcgacgacc cggcgcggcc
     6121 atggctggcg gaactggccg actacgagtg ggccgaactc ggcctgcaac tgagccaagc
     6181 cgccgcgccc gcgaccgatg cgatggccga cctgctcgac ggccgcccgg cgctgtcgcc
     6241 gctggcgtgg ccgcgcgcct accgctggcc ggtgcatcgc atcgggcccg atttccagcc
     6301 cggcgctcca ccgccgcagc cgacgctgct gctgctgcgc cgcgacgccg gcgggcgcgt
     6361 gcacttctcg cagctgtcgc cgctgctgta ccggctgctg gaactggcgg acggcaatac
     6421 cgaccgcagc ggccgcgcgc tgctgctgca gctcgccgcg gaagccggcc acgccgacat
     6481 cgccgccttc cagcaggagg ccctgccgat gctggcgcgg ctgcagcagg aaggcgtgct
     6541 gtactggcat ccgcaggtga cctgagacgc gccacttcgc gcgcaagttg ggaaactgta
     6601 aagagatgcg cgaaaaggag aaggcgccct gcactattcc cgcagtgcgg tgagtacctc
     6661 atgcggcgga tgcaaaaagc cacccgcacc ggcatcggaa tcggcatcct cctgatgggt
     6721 caacccgcga gccgcagcgc gctgccgctg cggtagagga tgtaggcggc gaccacgaac
     6781 acgaccccgg cgaagatccg cgtcagggtg ttgcgctggc tggccaggcg cagcgagagc
     6841 cgggtgccgg ccatcccgcc gagcaggccg ccggcgatga acagcccggc caccggccag
     6901 ttcaccatcc cggacagcgc gtagttgagc gcggtggcca ggccaaaggt gcccaccgcc
     6961 agcagcgagg agccgaccgc gttggccatc gacatcccgg tggcccagat cagcgccggc
     7021 acgatcagaa agccgccgcc gatcccgaag aacccggagg cgccgccagc caacagcgcc
     7081 gccaccccgg tgcgcaggca gtggcgcagg ttggtgatcg ggtgcgcggc gccgcgctcg
     7141 cgccgtgggc gcagcatggc gacgccgacc gcgaccatga tcaggccgaa caggaacagc
     7201 agcctctgcc cgtccatcgc cttgcccagg gtggaaccga gcagcgcgcc gacggtgccg
     7261 accagcgcga acacgatcgc gcaggcccag cacacgttgc gtcgccgcgc gtgcccggcg
     7321 aagttgaggt aggcattggc cgacaccgcc agcgcgccgg tgccgatcgc cacgtgcggc
     7381 tgcgcgatcc cgaccacgta cagcagcagc ggggtggcga ggatcgaacc gccaccgccg
     7441 atcaggccga gcacgaaccc gaccgcggcg ccggagccga gcgcggacag cgtctgccag
     7501 agctccagca tgttgctcag tctggcagct gccgcgccat ctggtaggcc agcgcgcaac
     7561 ggttgccgga ggcgcagtag gccagcacct tgcccggcgc ctgcgccagc acctgcttga
     7621 gctgcgccgc ctgggccggg gtcaccgcgc cggactgggc cgggatgtag tgggtctgca
     7681 ggccgtgctt tttcgcctcg gcttcgaccg cggcccaggc gggctggccg aacgcctcgc
     7741 cgtccgggcg catgcatacc agggtgcgat agccggcggc ggcgatcgcg gcgacctcgc
     7801 gcggatcgag ctgcgggctg acgtggtacg tgggggtgat gggggtgatg ggggtgatgg
     7861 gggtgatggc aggcatgggg gattctcctt gctggaatgg gagggcaaat gcgacttaca
     7921 gcgcgttcaa aggcagtttg aggaagtggc ggccgtcgcc atccggcggc ggcaggtggc
     7981 cggcgcgcat gttcacctgc aaggaaggca ggatcaggcg cggcatgccg agggtggcat
     8041 cgcgcgcctg gcgcatcgcc acgaaggcgt cttcatcgct gccatcggcg acatggatgt
     8101 tggactggcg ctcctcggcc acgctggtct gccagcggat ctcgcgcccg ttcgggccgt
     8161 agtcgtggca catgaacagg cgcgtctgcg gcggcagcgc caggatgcgc cgcgccgagc
     8221 ggtacagcgt gcgcgcatcc ccgccgggaa aatcggcgcg cgcggtgccg gcatccggca
     8281 tgaacagggt atcgccgacg aacgcggcat cgcccaccac gtgggtcatg cacgccgggg
     8341 tatgcccggg cgtgtgcagg gcgaaggcct ccagcgtgcc gatggcgtag cgctcgccat
     8401 cggcgaacag gtggtcgaac tggctgccgt cgcggcggaa ctcggtgcct tcgttgaaca
     8461 ccttgccgaa ggtgcgctgc acctccacga tcttctcgcc gatcccgatc ctgccgccca
     8521 gctgctgctg cagccagggc gcggcggaca ggtggtcggc gtggacgtgg gtttcgatca
     8581 gccactcgac ctgcaagccc tgcgcgcgca cgtggtccac gatccgctgc gccgaggcgt
     8641 acgtgatccg gccggcggcg ggatcgaagt ccagcaccgg gtcgatgatc gcgcaggccg
     8701 tgctggcggg atcgcgcacc acgtagctga tggtgttggt ggcggggtcg aagaacgccg
     8761 tcacctcggg gtgggcggac gacggcgctg gaaccggggg gatgtccata tgcggcgctc
     8821 ctgcatggca gtgctggcac tgtagggcgc cggcttccgc gagggaaacg aatttttccg
     8881 cacgctgtga tcgagtgatt cgatagcatc atccggcccg ctcccgaccg ctgccgcccg
     8941 ccatgcctgc cctgcccaat ctgcgccacc tgcgctatct ggtcgcgctg cacgatcacc
     9001 tgaacttcag ccgcgccgcg gaggcctgct tcgtcaccca gtccaccctg agcgccggca
     9061 tccgcgagct ggaagcgcag ctcggtgcgg ccgtggccga gcgcaaccgg cgcacggtcg
     9121 tcatcacccc gctcgggcac cggctggtgg cgcaggcgcg cacgctgctg cgcgaagccg
     9181 aggcgctgat ggcgatggcc gccgaggacg gcaatccgat ggcgggcctg ctggagctgg
     9241 gcgtactgcc gaccatcggc ccgttcctgc tgccgcgcct gattcccgcg ctgggccagg
     9301 ccttcccgca gctgcgcctg accctgcgcg aggatcacag cggcaacctg ctcgaccagc
     9361 tcgcgcaggg ccggctcgac ctggtgctga tggcctttcc gtacgacacc ccggggatgg
     9421 aaaccttccc gctgttcgcg gatgcctacc gcttcgtcgg ccccgcccgg gatgcgtcgg
     9481 cgtcgccgcc cggcggccgc gttccgctgg ccgcgcagct cgaaggccgc catctgctgc
     9541 tgctggagca cgaccactgc ctgcacggcc aggccatgcc ggcgctgcag caggccgccg
     9601 acggcggccg gatcaacttc gcctcgacca gcctgcatac cctggtggcg atggtggcag
     9661 ccggcatggg cgcgaccttc ctgccggacc tggcgatcac cggcggcatc ctgcgcgggc
     9721 ttccggtggt ggtgcagccg ctggacgtgg ccgagggcca gcgcacgatc gggctgtgct
     9781 ggcgacgcca cgcggcgcgg cgcgagactt ttctcgcgct cggcgggttc ctgcgcacct
     9841 gggcggcacg ggcgatccag ccctggacgc cggactgacc gccacgcaac gcccctctgc
     9901 taggctttgc cgatgacgga cctgatggat gcccgcgcgg atacgcccgc cttcgcgccg
     9961 atggcgcagc gtttccgcgg ctacctgccg gtggtagtgg acgtggagac cggcggcttc
    10021 gactgccagc gccacgcgct gctggaaatc gcggcggtgc cgatcgaact ggatgccgcc
    10081 ggtcgctacg tgccgggcga ggtcgcgcat gcgcatatcg cccccgcgcc cggcaccgag
    10141 atcgacccga aatcgctgga ggtgaccggc atcaagatcg gccacccgct gcgcggcgag
    10201 ctgcccgagc gcgaagggct ggatgcggtg ttcatcccgg tccgcgccgc ggtgaagcga
    10261 cacggctgcc agcgcgcgat cctggtcggc cacaacgcgc atttcgatct cggcttcctc
    10321 aacgcggcgg tggcgcgggt gcagcacaag cgcaatccgt tccatccgtt cagcgtgttc
    10381 gacaccgtga ccctggccgg cctggcctac gggcagaccg tgctggcgcg cgcggcgatg
    10441 gccgcgggcc tgggctggga cccgaaggaa gcgcattcgg cggtgtacga cgcgctgcag
    10501 accgcgcgcc tgttctgcgc gatcgccaac gcctggccgc tgccgaccgc gggcaacgca
    10561 ggcgccgcgg cggagcccgc ggacggggcc gcctgaacgc agcctttgct caggcgccgc
    10621 cgtccttgcg cgcgccgccg agggtgcgcg caatgccgta cacgctgatc gcgacccagg
    10681 tcgcttccag caggaacacc gagatgttga agctgcccca cagcgaggcc agcaccccgg
    10741 ccgcgcccag caggttcatc agctggtagg gcaggcggtt gccatgcagg cgcccggcct
    10801 gcagcaggaa atacgagagc ac
//
