GCF_022419205.1 - 3 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAJOZU010000001.1 (Thermomonas alba)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	terpene-precursor	8,705	29,580
Region 10.2	lassopeptide	322,620	346,789

NZ_JAJOZU010000004.1 (Thermomonas alba)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	RiPP-like	219,704	230,525

Region	Type	From	To	Most similar known cluster
Region 10.1	terpene-precursor	8,705	29,580
Region 10.2	lassopeptide	322,620	346,789
Region 21.1	RiPP-like	219,704	230,525

No secondary metabolite regions were found in these records:: NZ_JAJOZU010000010.1 (Thermomonas alba); NZ_JAJOZU010000011.1 (Thermomonas alba); NZ_JAJOZU010000012.1 (Thermomonas alba); NZ_JAJOZU010000013.1 (Thermomonas alba); NZ_JAJOZU010000014.1 (Thermomonas alba); NZ_JAJOZU010000015.1 (Thermomonas alba); NZ_JAJOZU010000016.1 (Thermomonas alba); NZ_JAJOZU010000017.1 (Thermomonas alba); NZ_JAJOZU010000018.1 (Thermomonas alba); NZ_JAJOZU010000019.1 (Thermomonas alba); NZ_JAJOZU010000020.1 (Thermomonas alba); NZ_JAJOZU010000021.1 (Thermomonas alba); NZ_JAJOZU010000022.1 (Thermomonas alba); NZ_JAJOZU010000023.1 (Thermomonas alba); NZ_JAJOZU010000024.1 (Thermomonas alba); NZ_JAJOZU010000025.1 (Thermomonas alba); NZ_JAJOZU010000026.1 (Thermomonas alba); NZ_JAJOZU010000002.1 (Thermomonas alba); NZ_JAJOZU010000003.1 (Thermomonas alba); NZ_JAJOZU010000005.1 (Thermomonas alba); NZ_JAJOZU010000006.1 (Thermomonas alba); NZ_JAJOZU010000007.1 (Thermomonas alba); NZ_JAJOZU010000008.1 (Thermomonas alba); NZ_JAJOZU010000009.1 (Thermomonas alba)

Compact view

NZ_JAJOZU010000001.1 - Region 1 - terpene-precursor

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Location: 8,705 - 29,580 nt. (total: 20,876 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: transferase

ML342_RS00120: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: peptidase

ML342_RS00085: gamma-glutamyltranspeptidase

smcogs: SMCOG1274: gamma-glutamyltranspeptidase

Ligases: synthetase

ML342_RS00100: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000779.3	0.44	saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0001605.3	0.41	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000840.5	0.39	other (other)	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000664.5	0.38	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000779.3	0.44	saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0001605.3	0.41	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000840.5	0.39	other (other)	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000664.5	0.38	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

ML342_RS00100: PT_FPPS_like

Domain 1 (31 - 290): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.13 out of 32.93

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.85 out of 26.12

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

NZ_JAJOZU010000001.1 - Region 2 - lassopeptide

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Location: 322,620 - 346,789 nt. (total: 24,170 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

ML342_RS01555: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: glycosyltransferase

ML342_RS01580: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase

ML342_RS01625: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: dehydratase

ML342_RS01590: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001634.3	0.51	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001356.4	0.51	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0000571.3	0.50	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002825.2	0.48	ribosomal	nocapeptin A	Nocardia terpenica IFM 0406
BGC0001639.3	0.47	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000786.3	0.43	saccharide	O-antigen	Edwardsiella ictaluri 93-146
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002575.2	0.43	ribosomal	cochonodin I	Streptococcus suis
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001634.3	0.51	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001356.4	0.51	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0000571.3	0.50	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002825.2	0.48	ribosomal	nocapeptin A	Nocardia terpenica IFM 0406
BGC0001639.3	0.47	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000786.3	0.43	saccharide	O-antigen	Edwardsiella ictaluri 93-146
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002575.2	0.43	ribosomal	cochonodin I	Streptococcus suis
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 20.47 out of 20.47

Confidence: strong

Additional weak hits (6):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.24 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.67 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.60 out of 21.84

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.18 out of 28.19

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.88 out of 30.98

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 6 - 86; Score: 72.8; RRE type: PqqD_RRE; Location: 20 - 87; Score: 32.6

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_JAJOZU010000004.1 - Region 1 - RiPP-like

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Location: 219,704 - 230,525 nt. (total: 10,822 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

ML342_RS08010: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.35	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002447.3	0.31	ribosomal	cerecyclin	Bacillus cereus
BGC0000565.5	0.30	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0000188.5	0.29	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000412.5	0.28	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0002568.2	0.27	other (other)	Ethylenediaminesuccinic acid hydroxyarginine	Streptomyces scabiei 87.22
BGC0002669.2	0.27	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0001283.3	0.23	PKS	Bisenarsan	Streptomyces lividans 1326
BGC0000651.5	0.23	terpene	KS-505a	Streptomyces argenteolus
BGC0000344.5	0.23	NRPS	entolysin	Pseudomonas entomophila L48

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.35	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002447.3	0.31	ribosomal	cerecyclin	Bacillus cereus
BGC0000565.5	0.30	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0000188.5	0.29	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000412.5	0.28	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0002568.2	0.27	other (other)	Ethylenediaminesuccinic acid hydroxyarginine	Streptomyces scabiei 87.22
BGC0002669.2	0.27	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87
BGC0001283.3	0.23	PKS	Bisenarsan	Streptomyces lividans 1326
BGC0000651.5	0.23	terpene	KS-505a	Streptomyces argenteolus
BGC0000344.5	0.23	NRPS	entolysin	Pseudomonas entomophila L48

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Additional weak hits (3):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.15 out of 30.22

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.31 out of 28.19

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production