GCF_022378335.1 - 8 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAIQCI010000009.1 (Croceicoccus hydrothermalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	terpene-precursor	77,556	98,455

NZ_JAIQCI010000013.1 (Croceicoccus hydrothermalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 17.1	lassopeptide	1,418	23,045

NZ_JAIQCI010000014.1 (Croceicoccus hydrothermalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 19.1	T3PKS	161,438	184,696

NZ_JAIQCI010000016.1 (Croceicoccus hydrothermalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 22.1	hserlactone	1,479	22,300

NZ_JAIQCI010000001.1 (Croceicoccus hydrothermalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 24.1	lassopeptide,hserlactone	1	23,228

NZ_JAIQCI010000002.1 (Croceicoccus hydrothermalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 34.1	terpene	69,447	93,152	Medium	zeaxanthin	terpene

NZ_JAIQCI010000004.1 (Croceicoccus hydrothermalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 56.1	lassopeptide	80,615	103,501

NZ_JAIQCI010000006.1 (Croceicoccus hydrothermalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 74.1	t3nrps-iterative	338,006	377,273

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	terpene-precursor	77,556	98,455
Region 17.1	lassopeptide	1,418	23,045
Region 19.1	T3PKS	161,438	184,696
Region 22.1	hserlactone	1,479	22,300
Region 24.1	lassopeptide,hserlactone	1	23,228
Region 34.1	terpene	69,447	93,152	Medium	zeaxanthin	terpene
Region 56.1	lassopeptide	80,615	103,501
Region 74.1	t3nrps-iterative	338,006	377,273

No secondary metabolite regions were found in these records:: NZ_JAIQCI010000078.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000079.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000080.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000084.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000085.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000086.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000087.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000088.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000010.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000089.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000011.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000090.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000012.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000092.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000093.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000094.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000095.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000015.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000017.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000018.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000019.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000020.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000021.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000022.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000023.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000024.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000025.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000026.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000027.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000028.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000029.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000030.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000031.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000032.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000033.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000034.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000035.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000036.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000003.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000037.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000038.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000039.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000040.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000041.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000042.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000043.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000044.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000045.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000046.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000047.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000048.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000049.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000050.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000051.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000052.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000053.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000054.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000055.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000056.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000005.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000057.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000058.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000059.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000060.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000062.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000064.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000065.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000066.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000067.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000069.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000007.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000070.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000071.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000072.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000073.1 (Croceicoccus hydrothermalis); NZ_JAIQCI010000074.1 (Croceicoccus hydrothermalis)

Compact view

NZ_JAIQCI010000009.1 - Region 1 - terpene-precursor

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Location: 77,556 - 98,455 nt. (total: 20,900 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase

K4G67_RS08600: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

Ligases: synthetase

K4G67_RS08575: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002163.3	0.51	other (other)	fusatin, fusatinic acid, 8-oxo-fusatin, 8-oxo-isopentenyladenine	Fusarium pseudograminearum CS3096
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0000779.3	0.45	saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000841.5	0.41	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0001579.4	0.41	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000486.4	0.41	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001605.3	0.40	terpene	gibberellin	Sinorhizobium fredii NGR234

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002163.3	0.51	other (other)	fusatin, fusatinic acid, 8-oxo-fusatin, 8-oxo-isopentenyladenine	Fusarium pseudograminearum CS3096
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0000779.3	0.45	saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000841.5	0.41	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0001579.4	0.41	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000486.4	0.41	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001605.3	0.40	terpene	gibberellin	Sinorhizobium fredii NGR234

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

K4G67_RS08575: PT_FPPS_like

Domain 1 (37 - 298): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46

Confidence: strong

Additional weak hits (6):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.78 out of 20.01

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.20 out of 26.12

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.68 out of 27.78

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.22 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.44 out of 29.38

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.25 out of 30.98

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
RpoN	Regulator of nitrogen assimilation and virulence

NZ_JAIQCI010000013.1 - Region 1 - lassopeptide

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Location: 1,418 - 23,045 nt. (total: 21,628 nt) Show pHMM detection rules used

Region on contig edge.

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: glycosyltransferase

K4G67_RS09365: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase

K4G67_RS09350: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: dehydratase

K4G67_RS09325: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

K4G67_RS09330: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

K4G67_RS09380: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

K4G67_RS09300: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

K4G67_RS09320: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000737.3	0.53	saccharide	capsular polysaccharide	Pasteurella multocida
BGC0002312.2	0.53	ribosomal	ubonodin	Burkholderia ubonensis
BGC0001550.3	0.53	ribosomal	citrulassin D	Streptomyces katrae
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0000575.5	0.52	ribosomal	lariatin	Rhodococcus jostii
BGC0002053.3	0.51	ribosomal	ulleungdin	Streptomyces sp.
BGC0000757.3	0.51	saccharide	capsular polysaccharide	Avibacterium paragallinarum
BGC0000756.3	0.50	saccharide	capsular polysaccharide	Avibacterium paragallinarum
BGC0001889.2	0.50	ribosomal	fusilassin	Thermobifida fusca YX
BGC0001356.4	0.49	ribosomal	paeninodin	Paenibacillus dendritiformis C454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000737.3	0.53	saccharide	capsular polysaccharide	Pasteurella multocida
BGC0002312.2	0.53	ribosomal	ubonodin	Burkholderia ubonensis
BGC0001550.3	0.53	ribosomal	citrulassin D	Streptomyces katrae
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0000575.5	0.52	ribosomal	lariatin	Rhodococcus jostii
BGC0002053.3	0.51	ribosomal	ulleungdin	Streptomyces sp.
BGC0000757.3	0.51	saccharide	capsular polysaccharide	Avibacterium paragallinarum
BGC0000756.3	0.50	saccharide	capsular polysaccharide	Avibacterium paragallinarum
BGC0001889.2	0.50	ribosomal	fusilassin	Thermobifida fusca YX
BGC0001356.4	0.49	ribosomal	paeninodin	Paenibacillus dendritiformis C454

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptide(s) for K4G67_RS09335

K4G67_RS09335

Leader:

MTDKSTYVSPVLEMIGSFEELTM

Full core:

GNSSGATLDFDFPVGTPDGELTLS

Putative macrolactam:

GNSSGATLD

antiSMASH-DB 4.0 matches for K4G67_RS09335

100.0%

NZ_JAIQCI010000013.1:

Lassopeptides: K4G67_RS09335_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

GNSSGATLDFDFPVGTPDGELTLS

1

GNSSGATLDFDFPVGTPDGELTLS

24

62.5%

NZ_CP009122.1:

Lassopeptides: SKP52_RS26305_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G SSG+ LD DFP GTP +LT S

1

GGSSGSNLDADFPSGTPFSDLTFS

24

62.5%

NZ_CP020925.1and 8 others:

NZ_CP023741.1 Lassopeptides: A6768_RS06865_lassopeptideNZ_CP029335.1 Lassopeptides: DIZ22_RS06300_lassopeptideNZ_CP039248.1 Lassopeptides: E5554_RS14505_lassopeptideNZ_CP047218.1 Lassopeptides: GS397_RS09490_lassopeptideNZ_CP053021.1 Lassopeptides: HH800_RS07780_lassopeptideNZ_CP115456.1 Lassopeptides: PAE53_RS09155_lassopeptideNZ_FRCG01000001.1 Lassopeptides: BUA63_RS24050_lassopeptideNZ_JH992904.1 Lassopeptides: HMPREF9718_RS26505_lassopeptide

Lassopeptides: BV87_RS15085_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G S G +LD FP GTP GELT S

1

GTSYGESLDATFPDGTPRGELTFS

24

with 85 more sequence matches

Only the first 10 are displayed here.

62.5%

NZ_CP092483.1:

Lassopeptides: MF606_RS02785_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G+S+G+ LD FPVGTP G+LT S

1

GSSTGSFLDATFPVGTPFGDLTFS

24

62.5%

NZ_JARGDK010000013.1:

Lassopeptides: P0X85_RS13470_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G +SG+ LD DFP GTP G+LT S

1

GQTSGSKLDADFPDGTPFGDLTFS

24

62.5%

NZ_JPKW01000011.1:

Lassopeptides: allorf_150084_150230_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G+SSG+ LD FP GTP G+LT S

1

GSSSGSRLDNTFPTGTPFGDLTFS

24

62.5%

NZ_QKZS01000007.1:

Lassopeptides: LX76_RS12500_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G+S G +LD FPVGTP G+LT S

1

GSSVGNSLDAAFPVGTPRGDLTFS

24

62.5%

NZ_SKCG01000002.1:

Lassopeptides: E0473_RS10090_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G+S+G TLD FPVGTP+ LT S

1

GSSTGNTLDQAFPVGTPEENLTFS

24

58.3%

NC_015730.1:

Lassopeptides: RLO149_RS23420_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G S+G++LD FP GTP +LTLS

1

GGSTGSSLDAAFPAGTPFADLTLS

24

58.3%

NZ_CP009110.1and 1 other:

NZ_KI421511.1 Lassopeptides: AMYTH_RS49055_lassopeptide

Lassopeptides: AMETH_RS37680_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G SSG+ LD DF GT G+LT S

1

GQSSGSRLDADFAAGTIFGDLTFS

24

58.3%

NZ_CP020612.1:

Lassopeptides: allorf_0899068_0899265_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G S+G LD FPVGTP +LT S

1

GASTGNALDRQFPVGTPKSQLTFS

24

58.3%

NZ_CP027407.1:

Lassopeptides: CEP88_RS08565_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G S+G++LD FP GTP +LTLS

1

GGSTGSSLDAAFPAGTPFTDLTLS

24

58.3%

NZ_CP034767.1:

Lassopeptides: ELX51_RS02725_lassopeptide

1

GNSSGATLDFDFPVGTPDGELTLS

24

G S+G+ LD FP GTP G+LT S

1

GASTGSALDATFPTGTPFGDLTFS

24

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.54 out of 26.33

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.19 out of 21.55

Confidence: medium

Additional weak hits (3):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 21.33 out of 36.54

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 30.11

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.10 out of 29.65

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

K4G67_RS09335 - Class II: Cleavage pHMM score: 1.60; RODEO score: 23; Monoisotopic mass: 2378.1 Da; Molecular weight: 2379.5 Da; Number of bridges: 0

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 1 - 66; Score: 64.8; RRE type: Thurincin_rSAM_RRE; Location: 7 - 63; Score: 25.2

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
ArcA	Repressor of carbon oxidation

NZ_JAIQCI010000014.1 - Region 1 - T3PKS

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Location: 161,438 - 184,696 nt. (total: 23,259 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

K4G67_RS10165: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase sulfhydrylase

K4G67_RS10240: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

K4G67_RS10265: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Ligases: synthase

K4G67_RS10225: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

K4G67_RS10260: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.53	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001962.3	0.50	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002332.2	0.45	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0000255.5	0.41	PKS	pederin	Uncultured bacterium
BGC0000894.4	0.39	other (other)	citrinin	Monascus aurantiacus
BGC0000815.4	0.38	other (other)	loline, N-acetylnorloline, N-formylloline	Epichloe uncinata
BGC0001521.3	0.37	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000783.3	0.37	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0001267.3	0.37	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.53	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001962.3	0.50	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002332.2	0.45	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0000255.5	0.41	PKS	pederin	Uncultured bacterium
BGC0000894.4	0.39	other (other)	citrinin	Monascus aurantiacus
BGC0000815.4	0.38	other (other)	loline, N-acetylnorloline, N-formylloline	Epichloe uncinata
BGC0001521.3	0.37	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000783.3	0.37	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0001267.3	0.37	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.58 out of 23.79

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.81 out of 18.57

Confidence: medium

Additional weak hits (14):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.45 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.78 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.91 out of 29.38

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.52 out of 29.65

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.90 out of 20.01

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.13 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.46 out of 26.06

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.12 out of 30.98

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.02 out of 29.65

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.15 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.55 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.04 out of 21.84

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.77 out of 33.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis

NZ_JAIQCI010000016.1 - Region 1 - hserlactone

Download region GenBank file

Download region SVG

Location: 1,479 - 22,300 nt. (total: 20,822 nt) Show pHMM detection rules used

Region on contig edge.

hserlactone: Autoind_synth

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

K4G67_RS10350: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001222.3	0.39	ribosomal	acidocin B	Lactobacillus acidophilus
BGC0000491.5	0.39	ribosomal	gassericin A	Lactobacillus gasseri
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0000577.3	0.37	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0000563.4	0.36	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001364.3	0.36	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0001226.4	0.36	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001291.3	0.36	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0000188.5	0.36	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000574.3	0.36	ribosomal	caulosegnin I, caulosegnin II, caulosegnin III	Caulobacter segnis ATCC 21756

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001222.3	0.39	ribosomal	acidocin B	Lactobacillus acidophilus
BGC0000491.5	0.39	ribosomal	gassericin A	Lactobacillus gasseri
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0000577.3	0.37	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0000563.4	0.36	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001364.3	0.36	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0001226.4	0.36	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001291.3	0.36	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0000188.5	0.36	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000574.3	0.36	ribosomal	caulosegnin I, caulosegnin II, caulosegnin III	Caulobacter segnis ATCC 21756

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.80 out of 18.16

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.89 out of 18.16

Confidence: strong

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31

Confidence: medium

Additional weak hits (6):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.06 out of 28.14

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.88 out of 21.84

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.85 out of 27.78

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.36 out of 21.55

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.86 out of 30.25

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.28 out of 27.55

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CatR	H2O2-responsive repressor

NZ_JAIQCI010000001.1 - Region 1 - hserlactone,lassopeptide

Download region GenBank file

Download region SVG

Location: 1 - 23,228 nt. (total: 23,228 nt) Show pHMM detection rules used

Region on contig edge.

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)
hserlactone: Autoind_synth

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

K4G67_RS00030: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000573.3	0.58	ribosomal	caulonodin I, caulonodin II	Caulobacter sp. K31
BGC0000577.3	0.53	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0001786.3	0.51	ribosomal	subterisin	Novosphingobium subterraneum
BGC0000576.3	0.46	ribosomal	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0000570.3	0.39	ribosomal	astexin-1	Asticcacaulis excentricus CB 48
BGC0000580.3	0.39	ribosomal	xanthomonin II, xanthomonin I	Xanthomonas gardneri ATCC 19865
BGC0000574.3	0.36	ribosomal	caulosegnin I, caulosegnin II, caulosegnin III	Caulobacter segnis ATCC 21756
BGC0001539.4	0.32	ribosomal	cattlecin	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0002334.3	0.25	other (other), ribosomal	heptyltyrazolone, nonyltyrazolone, undecyltyrazolone, (Z)-ω-6-undecenyltyrazolone	Pseudoalteromonas rubra
BGC0000190.5	0.15	PKS	A-74528	Streptomyces sp. SANK 61196

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000573.3	0.62	ribosomal	caulonodin I, caulonodin II	Caulobacter sp. K31
BGC0001786.3	0.60	ribosomal	subterisin	Novosphingobium subterraneum
BGC0000577.3	0.60	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0000576.3	0.56	ribosomal	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0000570.3	0.52	ribosomal	astexin-1	Asticcacaulis excentricus CB 48
BGC0000580.3	0.52	ribosomal	xanthomonin II, xanthomonin I	Xanthomonas gardneri ATCC 19865
BGC0000574.3	0.50	ribosomal	caulosegnin I, caulosegnin II, caulosegnin III	Caulobacter segnis ATCC 21756
BGC0001539.4	0.46	ribosomal	cattlecin	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0002334.3	0.41	other (other), ribosomal	heptyltyrazolone, nonyltyrazolone, undecyltyrazolone, (Z)-ω-6-undecenyltyrazolone	Pseudoalteromonas rubra
BGC0002133.3	0.37	ribosomal	group 1 methanobactin	Methylosinus sp. LW3

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptide(s) for K4G67_RS00040

K4G67_RS00040

Leader:

MDTHELHDELVDLGVASVETQ

Full core:

GDGLDPFDIGGLQRVAG

Putative macrolactam:

GDGLDPFD

K4G67_RS00040

Cleaved off residues:

IGED

antiSMASH-DB 4.0 matches for K4G67_RS00040

100.0%

NZ_CP087587.1and 1 other:

NZ_JAIQCI010000001.1 Lassopeptides: K4G67_RS00040_lassopeptide

Lassopeptides: LOZ74_RS13275_lassopeptide

1

GDGLDPFDIGGLQRVAG

17

GDGLDPFDIGGLQRVAG

1

GDGLDPFDIGGLQRVAG

17

47.1%

NZ_SLXW01000011.1:

Lassopeptides: C8J43_RS19855_lassopeptide

1

GDGLDPFDIGGLQ

13

GDG +IGGLQ

1

GDGTAQVEIGGLQ

13

33.3%

NZ_CP102384.1:

Lassopeptides: NP825_RS20050_lassopeptide

6

PFDIGGLQRVAG

17

PF+ GGLQ + G

6

PFETGGLQNIPG

17

with 1 more sequence matches

33.3%

NZ_NISK01000001.1:

Lassopeptides: CDQ92_RS20735_lassopeptide

6

PFDIGGLQRVAG

17

PF++GGLQ + G

6

PFELGGLQNIPG

17

MIBiG 4.0 matches for K4G67_RS00040

7.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

3

GLDPFDIG

10

G D FD+

14

GYDDFDLN

21

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.04 out of 18.57

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.71 out of 23.79

Confidence: medium

Additional weak hits (7):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.07 out of 30.22

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.40 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.65 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.87 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.87 out of 29.38

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

K4G67_RS00040 - Class II: Cleavage pHMM score: 13.30; RODEO score: 20; Monoisotopic mass: 1667.8 Da; Molecular weight: 1668.8 Da; Number of bridges: 0

RRE predictions

: RRE type: Lasso_Fused_RRE; Location: 0 - 63; Score: 48.4

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis

NZ_JAIQCI010000002.1 - Region 1 - terpene

Download region GenBank file

Download region SVG

Location: 69,447 - 93,152 nt. (total: 23,706 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

K4G67_RS01335: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Hydrolases: hydrolase

K4G67_RS01280: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: synthase

K4G67_RS01295: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000656.5	0.79	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000630.3	0.60	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000640.3	0.60	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000638.3	0.59	terpene	carotenoid	Pantoea ananatis
BGC0000647.3	0.59	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000639.3	0.58	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.58	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000635.3	0.57	terpene	carotenoid	Paracoccus sp. N81106
BGC0000642.3	0.57	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000646.5	0.56	terpene	β-carotein	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000656.5	0.79	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000630.3	0.60	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000640.3	0.60	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000638.3	0.59	terpene	carotenoid	Pantoea ananatis
BGC0000647.3	0.59	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000639.3	0.58	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.58	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000635.3	0.57	terpene	carotenoid	Paracoccus sp. N81106
BGC0000642.3	0.57	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000646.5	0.56	terpene	β-carotein	uncultured bacterium

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

K4G67_RS01330: PT_phytoene_like

Domain 1 (18 - 314): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → PSPP; FPP → squalene; GGPP → phytoene; PSPP → hydroxysqualene

K4G67_RS01340: Lycopene_cycl

Domain 1 (6 - 380): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52

Confidence: medium

Additional weak hits (6):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.70 out of 29.38

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.40 out of 21.55

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.46 out of 21.55

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.70 out of 26.12

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.67 out of 27.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.89 out of 29.65

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

NZ_JAIQCI010000004.1 - Region 1 - lassopeptide

Download region GenBank file

Download region SVG

Location: 80,615 - 103,501 nt. (total: 22,887 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

K4G67_RS04500: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001634.3	0.53	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001645.3	0.53	ribosomal	lagmysin	Streptomyces sp. NRRL S-118
BGC0001549.3	0.52	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001552.3	0.52	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000575.5	0.52	ribosomal	lariatin	Rhodococcus jostii
BGC0001889.2	0.49	ribosomal	fusilassin	Thermobifida fusca YX
BGC0001356.4	0.49	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0001496.3	0.47	ribosomal	actinokineosin	Actinokineospora spheciospongiae
BGC0000578.3	0.42	ribosomal	SRO15-2005	Streptomyces filamentosus NRRL 15998
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001634.3	0.53	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001645.3	0.53	ribosomal	lagmysin	Streptomyces sp. NRRL S-118
BGC0001549.3	0.52	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001552.3	0.52	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000575.5	0.52	ribosomal	lariatin	Rhodococcus jostii
BGC0001889.2	0.49	ribosomal	fusilassin	Thermobifida fusca YX
BGC0001356.4	0.49	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0001496.3	0.47	ribosomal	actinokineosin	Actinokineospora spheciospongiae
BGC0000578.3	0.42	ribosomal	SRO15-2005	Streptomyces filamentosus NRRL 15998
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.89 out of 23.79

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.90 out of 28.19

Confidence: medium

Additional weak hits (10):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.27 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.91 out of 39.62

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.76 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.08 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.77 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.44 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.61 out of 29.38

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.58 out of 30.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.27 out of 28.19

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.84 out of 20.01

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 11 - 86; Score: 58.9; RRE type: PqqD_RRE; Location: 28 - 86; Score: 30.3

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
MexT	Global virulence regulator
RpoN	Regulator of nitrogen assimilation and virulence
ZuR variant 1	Zinc-responsive repressor

NZ_JAIQCI010000006.1 - Region 1 - t3nrps-iterative

Download region GenBank file

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Location: 338,006 - 377,273 nt. (total: 39,268 nt) Show pHMM detection rules used

Region on contig edge.

t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase reductase

K4G67_RS07030: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

K4G67_RS07065: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K4G67_RS07120: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Transferases: methyltransferase phosphorylase transketolase

K4G67_RS07040: methyltransferase

smcogs: SMCOG1089: methyltransferase

K4G67_RS07135: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

K4G67_RS07165: transketolase

smcogs: SMCOG1204: transketolase

Lyases: decarboxylase

K4G67_RS07105: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase

K4G67_RS07110: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001206.5	0.45	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0001873.3	0.44	NRPS	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0002439.3	0.44	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus
BGC0002527.2	0.43	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000694.3	0.40	saccharide	butirosin	Bacillus circulans
BGC0000622.5	0.40	ribosomal	megacin	Bacillus megaterium
BGC0000678.5	0.39	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001314.3	0.39	terpene	tirucalla	Arabidopsis thaliana
BGC0002199.2	0.39	other (other)	nanangelenin A	Aspergillus nanangensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001206.5	0.45	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0001873.3	0.44	NRPS	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0002439.3	0.44	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus
BGC0002527.2	0.43	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000694.3	0.40	saccharide	butirosin	Bacillus circulans
BGC0000622.5	0.40	ribosomal	megacin	Bacillus megaterium
BGC0000678.5	0.39	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001314.3	0.39	terpene	tirucalla	Arabidopsis thaliana
BGC0002199.2	0.39	other (other)	nanangelenin A	Aspergillus nanangensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.07 out of 25.31

Confidence: medium

Additional weak hits (9):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.69 out of 20.97

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.40 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.43 out of 29.38

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.87 out of 25.88

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.24 out of 27.78

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.03 out of 24.78

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.39 out of 39.62

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.27 out of 25.88

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.36 out of 29.25

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

K4G67_RS07110: X

AMP-binding (16..411): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GAVLFDYGQNQSAGTNSGGYPMYGLTEAFRSTFL
Nearest Stachelhaus code(s):: Asp DYYPTTMRAK (50% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor