LOCUS       NZ_JAIQCI010000013     21628 bp    DNA     linear   CON 28-MAR-2024
DEFINITION  Croceicoccus hydrothermalis strain JLT1
            NODE_15_length_22961_cov_175.249557, whole genome shotgun sequence.
ACCESSION   NZ_JAIQCI010000013
VERSION     NZ_JAIQCI010000013.1
KEYWORDS    WGS; RefSeq.
SOURCE      Croceicoccus hydrothermalis
  ORGANISM  Croceicoccus hydrothermalis
            Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
            Erythrobacteraceae; Croceicoccus.
REFERENCE   1  (bases 1 to 23045)
  AUTHORS   Chen,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-SEP-2021) State Key Laboratory for Marine
            Environmental Science, Institute of Marine Microbes and Ecospheres,
            Xiamen University, A3-302, Zhoulongquan Building, Xiang'an, Xiamen,
            Fujian 361102, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Velvet v. 2019-11-6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 521.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022378335.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 07:11:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,506
            CDSs (total)                      :: 3,455
            Genes (coding)                    :: 3,380
            CDSs (with protein)               :: 3,380
            Genes (RNA)                       :: 51
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 45
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 75
            CDSs (without protein)            :: 75
            Pseudo Genes (ambiguous residues) :: 0 of 75
            Pseudo Genes (frameshifted)       :: 30 of 75
            Pseudo Genes (incomplete)         :: 44 of 75
            Pseudo Genes (internal stop)      :: 22 of 75
            Pseudo Genes (multiple problems)  :: 17 of 75
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:29:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1417
            Orig. end                         :: 23045
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAIQCI010000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21628
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..21628
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21628
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12496](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12496
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    145..158
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.54"
                     /tool="antismash"
     gene            1724..2716
                     /locus_tag="K4G67_RS09300"
     CDS             1724..2716
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF025025.4"
                     /locus_tag="K4G67_RS09300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_239806106.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.9e-39,
                     bitscore: 125.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVPSYNAAATLDETLLSIREQSHRNLEIIVVDDGSKDNTRDVAE
                     RQAAIDPRIRVVTQENGGVAAARNHGIELAKGEFIAPVDADDLWRPRKIERQLRAMHSA
                     GPYTGLVYCWSAVIDEESSVISRANSPSHAGDVLPQLFYGNFVGNGSSALMRKDLVQGV
                     GGFDPSLRARKAQGCEDWKLYLLLAERSHFAVIPDYLVGYRSTAAAMSGDVSQMLRSDA
                     IVRGEMAVRHPNSRLELEWGRRHYLEWMLWRELDALNWQNCMTLIHERRAESRPLRMVA
                     RRAKLGAKFFRQKMRRKSGSVVGAPFLENGVTADAGLTLPFGSPSGNIG"
     gene            complement(2693..3904)
                     /locus_tag="K4G67_RS09305"
     CDS             complement(2693..3904)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019833545.1"
                     /locus_tag="K4G67_RS09305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_239806107.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.8e-28,
                     bitscore: 88.9, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRSPAHSDPSAIQSCQSIEPFADIFRSPIDKASPIVAGRPALVI
                     FEADGLPAGQQWLKPGEQADPSEEIAARIEARRERPIRASAGYSTSVVICTRDRPEELR
                     RCLASFADQSWTPDELIVVDNASRDQRTRDVVLSAGATYIREDRPGLDFARNSGARAAH
                     GDIVLYTDDDTELHERWVESTIAAFDAPDIMAVTGLVLPARLDTEAQWIFETEWSFGRG
                     FDRIDYGYDFFSQNGRYGCPAWIVGAGANMAFRRIIFDRVGYFDERLDVGQAGCSGDSE
                     FWYRILAAGYICRYEPLAVMFHHHRLEMSGLASQIYHYMRGHTAALMVQYQRTGETGNL
                     RRAFVLLPKYYLGLLANRLKNGLTNKNRFLAEQIKGAAAGIWFFIRNRQMPAPPAESSD
                     IPRR"
     misc_feature    3950..3968
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 21.33"
                     /tool="antismash"
     misc_feature    4031..4045
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 21.7"
                     /tool="antismash"
     gene            4187..4948
                     /locus_tag="K4G67_RS09310"
     CDS             4187..4948
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="K4G67_RS09310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_239806123.1"
                     /transl_table=11
                     /translation="MRLNHWKDVVLLLVSRDFRGRYKHTKVGILWSLASPIMFLLIFYF
                     LFQRVINLDIPRYASYAFTGIIVWNWTQQALIASVTSISANQGLVAQPGFPVAALPVIS
                     VLSALLNLAIAFPLLLALSWIDGATPTFVLIALPVVIIAQFLFILSVAYIIAALNVGLR
                     DVEQILPIILQLGYYVTPIFFSLQNVPPDFHVMFRFNPMTWVISSYRDIVMYGIWPNWT
                     ALGIITAGSCLFLVFGVRIFSRARYRFLEEL"
     gene            5032..6195
                     /locus_tag="K4G67_RS09315"
     CDS             5032..6195
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="K4G67_RS09315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_275588814.1"
                     /transl_table=11
                     /translation="MRRGFRAAKVSDHFWAVRDVSFQVKPGEMLGIIGHNGSGKSTMLR
                     IVGGVMRADTGSVVTTGSISGLLELNAGMHQELSGRDNVLIGGVIAGLTRRQIAARMDE
                     IIAFAELEDFIDSPVRTYSAGMRLRLGFSVAIHTDPGVLLIDEVLSVGDLAFQAKCLDR
                     IRRHRDEGSAIILITHDLSQVEKLCTDALWLRKGEVVAHGPPDVLSGEYRAAMAQQTRE
                     RTYSEMPDEISTGGIVLRAHENRFGSLEKKIDAVSLRDRSEAIVDAIETGAPLSIEVCF
                     TEGGISEPIVSVTIATAEEIKCLDVNTEADEAILNDTGKKGVVRLELDRVDLAAGRYFV
                     SVGIFPAGWEYAYDYHWHAYPLNITGSTEDVGKLSPPRRWTTNALEE"
     gene            6361..7359
                     /locus_tag="K4G67_RS09320"
     CDS             6361..7359
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF021616.4"
                     /locus_tag="K4G67_RS09320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_239806109.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.5e-41,
                     bitscore: 131.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPLPPSQPNADDHRSERLISVIIPAYNSADTLTDTLNSVLAQTY
                     SLIEVIVVDDGSTDNTFNIAREHAASDPRVRVIQQANGGVAKARNTAISVSTADLIAPI
                     DADDLWHPAKLERQLDVLKAFPNIGLVYTWFAKIDRQGRIIEFESRHTAEGNVLAELCV
                     HNIVGHASSPLVTRAAIEHAGGYDETLRARNAQGCEDNKLYLAIAEHYNFAVVKEHLVG
                     YREMPEGMSSDFQQMLRSRDLCIKETVDRHPALVAIARRGRFQMLKWMLLRALRSRMYR
                     LSSQLLFEMLQTAPTSTAAYIMRFVFRRLTGARRATHDPMVGKPFVQLWSE"
     gene            complement(7421..8401)
                     /gene="galE"
                     /locus_tag="K4G67_RS09325"
     CDS             complement(7421..8401)
                     /EC_number="5.1.3.2"
                     /GO_function="GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (65-173). E-value:
                     3.4e-10. Score: 31.4. Matches aSDomain:
                     nrpspksdomains_K4G67_RS09325_NAD_binding_4.1"
                     /codon_start=1
                     /gene="galE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019833544.1"
                     /locus_tag="K4G67_RS09325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="WP_239806110.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.2e-18, bitscore:
                     56.8, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.6e-10,
                     bitscore: 30.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVLVIGGAGYVGSHCCKAFAAAGWRVVCFDNLSRGWRDAVKWG
                     PLIEGDLLNRSEISAAVRDTRPDLIAHFAAFAYVGESVASPEIYYRNNCVGTINMLDAM
                     LEYEVKPLLFSSTCASYGIPQHLPIDENHPQVPINPYGESKLMAEKMLRDYGAAHGLRT
                     VALRYFNAAGADADGEIGERHEPETHAIPLTIEAAIDPDATFTVMGTDFDTRDGSAVRD
                     YIHVTDLASAHVAAGAFALANEGSHIFNLGTGVGTTVLELLAAVERIAGRRPSVEMGGR
                     RAGDPAALVASYEKAQRVLGWQPQCSDIDTIVDTALAWRRSRAGA"
     aSDomain        complement(7883..8206)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K4G67_RS09325_NAD_binding_4.1"
                     /evalue="3.40E-10"
                     /label="K4G67_RS09325_NAD_binding_4.1"
                     /locus_tag="K4G67_RS09325"
                     /protein_end="173"
                     /protein_start="65"
                     /score="31.4"
                     /tool="antismash"
                     /translation="RPDLIAHFAAFAYVGESVASPEIYYRNNCVGTINMLDAMLEYEVK
                     PLLFSSTCASYGIPQHLPIDENHPQVPINPYGESKLMAEKMLRDYGAAHGLRTVALRYF
                     NAAG"
     CDS_motif       complement(8327..8395)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K4G67_RS09325_0001"
                     /evalue="2.30E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="K4G67_RS09325"
                     /protein_end="25"
                     /protein_start="2"
                     /score="10.6"
                     /tool="antismash"
                     /translation="TVLVIGGAGYVGSHCCKAFAAAG"
     gene            complement(8398..9414)
                     /locus_tag="K4G67_RS09330"
     CDS             complement(8398..9414)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014075921.1"
                     /locus_tag="K4G67_RS09330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UDP-glucuronic acid decarboxylase family protein"
                     /protein_id="WP_239806111.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.8e-09, bitscore:
                     26.1, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVEVQQRALVTGGAGFLGSFLCERLIEDGRDVVCVDNFFTGRKQ
                     NIAHLMSNPNFEVLRHDVTIPLYLEVDEIYNLACPASPVHYQYDPVSTTKTSVHGAINM
                     LGLAKRTKARIFQASTSEVYGDPLVHPQREDYWGHVNPIGPRSCYDEGKRCAETLFFDY
                     WRQFQLKIKVARIFNTYGPRMRPDDGRVVSNFIVQALMGQPITIYGDGTQTRSFCYVDD
                     LIDGFIAMMHSPADMTGPVNIGNPNEFTIGELAELVIELTNSRSEIVHKALPVNDPKQR
                     QPDISLAKDALNWEPKVKLREGLVKTIAYFDGFLREKGAIGEDSAANLTSKRDERVS"
     misc_feature    complement(9644..9661)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.19"
                     /tool="antismash"
     gene            9723..9866
                     /locus_tag="K4G67_RS09335"
     CDS             9723..9866
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004212599.1"
                     /locus_tag="K4G67_RS09335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_239806112.1"
                     /transl_table=11
                     /translation="MTDKSTYVSPVLEMIGSFEELTMGNSSGATLDFDFPVGTPDGELT
                     LS"
     CDS_motif       9723..9791
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MTDKSTYVSPVLEMIGSFEELTM"
                     /locus_tag="K4G67_RS09335_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       9792..9866
                     /prepeptide="core"
                     /locus_tag="K4G67_RS09335_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="1.60"
                     /molecular_weight="2379.5"
                     /monoisotopic_mass="2378.1"
                     /core_sequence="GNSSGATLDFDFPVGTPDGELTLS"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MTDKSTYVSPVLEMIGSFEELTM"
                     /leader_location="[9722:9791](+)"
     gene            10001..10225
                     /locus_tag="K4G67_RS17545"
     CDS             10001..10225
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thurincin_rSAM_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="K4G67_RS17545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PqqD family protein"
                     /protein_id="WP_338026416.1"
                     /sec_met_domain="PF05402 (E-value: 4.9e-20, bitscore: 62.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 6.1e-21,
                     bitscore: 64.8, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Thurincin_rSAM_RRE (E-value: 1.4e-08,
                     bitscore: 25.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLDLSSNAYFRLNEMGIEIWRKIEDGADEESIVDDLTNKYDAER
                     SQIAGDVRGFIEGLETAGLIVSGRVENSQ"
     aSDomain        10004..10198
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K4G67_RS17545_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="8.20E-21"
                     /identifier="RREFam002.1"
                     /label="K4G67_RS17545"
                     /locus_tag="K4G67_RS17545"
                     /protein_end="66"
                     /protein_start="1"
                     /score="64.8"
                     /tool="antismash"
                     /translation="VLDLSSNAYFRLNEMGIEIWRKIEDGADEESIVDDLTNKYDAERS
                     QIAGDVRGFIEGLETAGLIV"
     misc_feature    10019..10034
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.1"
                     /tool="antismash"
     aSDomain        10022..10189
                     /aSDomain="Thurincin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a thurincin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K4G67_RS17545_Thurincin_rSAM_RRE.1"
                     /evalue="1.90E-08"
                     /identifier="RREFam019.1"
                     /label="K4G67_RS17545"
                     /locus_tag="K4G67_RS17545"
                     /protein_end="63"
                     /protein_start="7"
                     /score="25.2"
                     /tool="antismash"
                     /translation="NAYFRLNEMGIEIWRKIEDGADEESIVDDLTNKYDAERSQIAGDV
                     RGFIEGLETAG"
     gene            10260..10634
                     /locus_tag="K4G67_RS09345"
     CDS             10260..10634
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="K4G67_RS09345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_239806114.1"
                     /sec_met_domain="PF13471 (E-value: 9.7e-19, bitscore: 58.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAFAIPCGFLIGLAVRMGRFEMVHRFLPNGPGKSQATAREVTIV
                     QRAVRRAIRLSPSETCLSQASLGKILMNLLDRQSVLHVGVRLGEDNTVRAHAWLSVRGI
                     TMVGGPDAKIAPFRQIAEFV"
     gene            10631..12496
                     /locus_tag="K4G67_RS09350"
     CDS             10631..12496
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="K4G67_RS09350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_239806115.1"
                     /sec_met_domain="GATase_7 (E-value: 5.5e-22, bitscore:
                     68.5, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 2.5e-47, bitscore:
                     152.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGLAGIIGEHGAEALQRRAGRMVSAVAYRGTPAVRMLDADKGIL
                     AQLGHTAAFDGLHIADRAIVGLSGRLDDPDVLATTLGLDATPSDEVLVYRAYLRWGTDF
                     VEYIQGEYAIFLWDRVEANLVLVRDRFGVEPLYYANTSSSFVFASEIKAILAAEPDLRG
                     ALREDLIVDYIANIHAAEPEQTIFKQILRVPAASIVMIRGREIIVRRYYTLDTTVRSCG
                     KDAPERFAERLSIAVRRRMRANGEIGALLSGGLDSSSITSLAAREVRGGRELPTYTSFY
                     KDDPDGEDPYADAVRRKYGLSHPVLIDADDINVFDDLSTRLRALDRPPYGPNNALAQHV
                     ARSVAATGTAQVILCGHGGDEIVSSGSSFLRELAQAKQWSRLWSEIGDTDVLGFPRARV
                     FRDLFLASSPMARRAARFVRMLNPAPKAPVASSWMQYVSPRVADAAAFSQRYDAARTPS
                     SDVRLPLSARSHIANLFNPMQVEAFEGLDQTRTPSGLLFRYPFWDKDLIELAISLPGEE
                     KWSRGWPRVLLRRAMKGILPEEVAWRPDKYNYVFRFKDSLRRAESVALISHALNEDAER
                     VSHYVNISHARGLLHDLQTGEIGPLDLFYLWRVTILSHWLEERDR"
     gene            12565..13440
                     /locus_tag="K4G67_RS09355"
     CDS             12565..13440
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K4G67_RS09355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_239806116.1"
                     /transl_table=11
                     /translation="MRIRSDIAFAELDPAPEGDVDLYIRLGPELDPEELQAAIENRRSD
                     GSEFLGKRMDFGAVGRYDITDDTITISPVIGIRHPDLSLPLLGPVLATYLHRRGMLILH
                     GNAVLLKDGLTVFVGDSGAGKSTTGGWFASNVGTLFTDDILPVRIAADGTPWVEPGYAL
                     VKLSSAAVEAFAPADAKILPVSFEGYPKLRVRLSRPAMPQTSTIRRICVLRRGEEAGYE
                     RLNDFAGFRAMVEHTYMAKYRDAFTSAERKALHLKQCSAVSRNVEIAILTVPFGIDRLH
                     EVLSVLEAAE"
     gene            13437..15206
                     /locus_tag="K4G67_RS17665"
     CDS             13437..15206
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="K4G67_RS17665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_239806117.1"
                     /transl_table=11
                     /translation="MRPGKFVSGWLGVLRRMAAPEPKRLVLTLGLTLIVALTENITIGL
                     LIPLITYAEPGAALLTLPLPGKVSDFAGNSELQIHIGVVLAILIALVIVRVLVQRSSDL
                     RTSALITRFVRRTRFSLFTAISQTRWSVLASQRTADLHHNLTAEVDRLSALAYSSLSAT
                     KAAIIVAIYLAVACLISPFLTVVALSLAGLIFLMQVPLHKKVRASGQRSLDIRTGQTRT
                     VSDFLSSLKVNKAFSLEPRYARTLDDLMIEQEETVRAYVSLQGRVNLIVQSAMIIGLSL
                     FVYTSLVVAETTQAEVLIILLLFFRLSGRTQAIQTALREIESNAPCLERLDGMIAQYSM
                     DEEEPVSAVVDAPRLHHEMRFDGVVLTYAGAKAPALDGVSLVIPARKLTALVGRTGSGK
                     TTIADLALGLLSTDSGSLTIDGVTLGNDNRRAWREYVSLVPQDPVLFHGSIRENLHLVR
                     PDATDAEMEEALETAHILATIRRLPHGLDTAVGDRGQMLSGGERQRLALARALLRKPAL
                     LVLDEATSALDSVTEAEVVRALADIRHETSILAITHRPALLDVADHVVLLRDGRIVEEG
                     TKKLSLDALYASE"
     gene            complement(15234..16364)
                     /locus_tag="K4G67_RS09365"
     CDS             complement(15234..16364)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012744.4"
                     /locus_tag="K4G67_RS09365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_239806118.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 6.2e-29,
                     bitscore: 91.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSTVILVTCEYPPFPGGIGTYSGRLAAVLAADGHRTIVICPRYD
                     GGQDLDEPTGIEYHRVLKHHGIRPIAAATLLRVLRRAPRDAVLIAADIRTLLLVHLLQP
                     LHRRPYRVMVHGSEAHKFRDGSLLFKLVRRAYLSADQVLYNSEATGAIFRAQVGQPKSD
                     TVTYLGVDDAWFEDPLSSAFEHEALAEIPPEAKVFCSVGRLEPRKGQIETVRALAFARD
                     RLSMDDPVYVVVGRAEDQAYADAIMGEARKYKLRTILTGKLSMDDVKRVYRRSTAHLLF
                     ARPLPGKVEGFGLVLLEAAAQKCPSIAAKTGGIPEVVADTGLLVEPDNIEELASAVLRI
                     TREPQAEATMGEAACRRAKDFSWRKCAERTFPSLYA"
     gene            complement(16368..17336)
                     /locus_tag="K4G67_RS09370"
     CDS             complement(16368..17336)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF021616.4"
                     /locus_tag="K4G67_RS09370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_239806119.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 7.2e-28,
                     bitscore: 88.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTERSQAPVAAILTCYNEGPYIGEAVRSILDQSRADLIREIVIAD
                     DGSHDDTLATLREIERWDDRIRVLYGSGGAGLPGQRCWAISETSSPYIAILDGDDIWVK
                     RKLELQVPILDERPEVGMVYGRFFTFPDFDKDRALLANTIDISKAGDLPVTYFLNDPPI
                     IPSTTLIRRDCYDASGGFDPQVKVFEDTDFFLRIIAVARLGFVDEPLLYKRNRNTSITG
                     GRKDLMAHHAFVALRAAANEPELLPLVPRRLAERARKLGNHRFLLNDREGALLWLRFAV
                     RLHPFNRRSWMSLVAVSVAPGLALRMLGRAGRERQSALGVN"
     gene            complement(17496..18761)
                     /locus_tag="K4G67_RS09375"
     CDS             complement(17496..18761)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021589.4"
                     /locus_tag="K4G67_RS09375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="outer membrane beta-barrel protein"
                     /protein_id="WP_239806120.1"
                     /transl_table=11
                     /translation="MKTHGSLHSETKKWSSSLSRIRGFFLLLLSGAFGTLPASQQAWSQ
                     SREISLKVLTVYDDNLFQLTDDQKDAVDPSDEFSTFVGANLEYNTRISLFDITVNGDIG
                     GRFYANNSQFNSEEYRLAGRTQYLAESGSAQFDAMLSRQNLSFSDPLFRGTNIRSLERF
                     SVRGDRRILSDFHVAGSARVSSSSSPGSDLRGVNNTIYAYSAGIEYVSPIKNRIGVGYS
                     QSRSEGDGLRTVLIGGDPILYSPEASSEGVYAEIIWTAPVTYSLSGRVGYTWHDDRSPR
                     DIDYQGLTYNVAASWAPLRSLNIAARAVRSFSSNDELFSNGVVLNSYSLGVSGTAYGRL
                     GFNAGIERAEREFRFLPRNGLEDSMNRTDKFWVLQAGLNYELGSGINAALSASRVLIDD
                     STIADDITSNAITLTLLKSFQF"
     gene            complement(18912..19925)
                     /locus_tag="K4G67_RS09380"
     CDS             complement(18912..19925)
                     /NRPS_PKS="Domain: NAD_binding_4 (77-190). E-value:
                     8.2e-12. Score: 36.7. Matches aSDomain:
                     nrpspksdomains_K4G67_RS09380_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003044777.1"
                     /locus_tag="K4G67_RS09380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_239806121.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.5e-22, bitscore:
                     70.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 5.1e-19,
                     bitscore: 58.9, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVMVTGTAGFIGFHLAKLLIAEGFRVVGVDSMTDYYDTALKQR
                     RHAILRESNAFSAEEFDVLDYPRLRKFMDQAAPEVIVHLAAQAGVRYSLEEPRAYVETN
                     ITGTFNVMECARELAVDHLLMASTSSVYGANEEMPYAETHKADTPMTIYAATKKANEAM
                     AHSYAHLWNLPTTMFRFFTVYGPYGRPDMALFKFTKGIKDGTPIDIYNHGEMWRDFTYV
                     EDLVRGIRLLIDVPPKRPDSRQDIAQGDSLSAAAPFRIVNIGNGDSVRLEDFIDALEQA
                     IGKPAVRNYMDMQAGDVPATWADSSLLFELTGYRPQTDVREGVRRFVDWYEDYYSE"
     aSDomain        complement(19356..19694)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K4G67_RS09380_NAD_binding_4.1"
                     /evalue="8.20E-12"
                     /label="K4G67_RS09380_NAD_binding_4.1"
                     /locus_tag="K4G67_RS09380"
                     /protein_end="190"
                     /protein_start="77"
                     /score="36.7"
                     /tool="antismash"
                     /translation="PEVIVHLAAQAGVRYSLEEPRAYVETNITGTFNVMECARELAVDH
                     LLMASTSSVYGANEEMPYAETHKADTPMTIYAATKKANEAMAHSYAHLWNLPTTMFRFF
                     TVYGPYGRP"
     gene            20201..21550
                     /locus_tag="K4G67_RS09385"
     CDS             20201..21550
                     /GO_process="GO:0009103 - lipopolysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Wzy_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016800.4"
                     /locus_tag="K4G67_RS09385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="O-antigen ligase family protein"
                     /protein_id="WP_239806122.1"
                     /sec_met_domain="Wzy_C (E-value: 2e-09, bitscore: 28.2,
                     seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQSIFRRRAKQIPQSARNRHSMFGIRSGKESRNLFGILLAAFLF
                     LLIGLAYKIAILQTVSMLVLATGIWAGRDAIGRVNMVFVLGLLYIASATVSAFLVSTGE
                     GMYRTAQFCIVAGGLTGIYLYSWHLGEEHALRALKLIAIVSVAIFAHLIIYHLSIGKYQ
                     TWKYLSDTKTVISLTVFLCFALQDEIRRRVPFPIVMAVLVWLIAASAERKAFLLFVIAA
                     AFSTLTWRAKIFLFGGGILLILLAASTGWDNGYLANRFQAAPIDVTTVSDRYFSTFQNI
                     GDYSDLVREFVNRNAWQLFKDNPFLGVGATGYRAWAFEVFGATDFAMNVHGEVHRVPAE
                     GGIVGIVIAIAYLAATIWRAFHFAFLRPERTGTALERTPLLLCLYVMSYAYAEAIDTGM
                     LVLIGVNSVVAARLPAPSLGNLMQRRLRRSGRRTPRRNTRGAGKRDPLPN"
ORIGIN
        1 ctgttttcta gctccgccat cagcgcattt gctgccggtc cctcaaggcc ttcgtaatcg
       61 tgccgggcat aatagttccg accataattt ttccagtgat cgagagccag cgcattgacg
      121 gaaatgcgcc gctccgcaag gatattgagc catagcaaca cggcccacag cccatccttc
      181 tcacgtacgt ggtcggaccc cgtgccggcg ctttcctcgc cgcagatcgt cacgaaaccg
      241 gcatcgagca ggttgccaaa aaacttccat cccgtggggg tttcatagca cggtacgtcc
      301 agcgcattgg ccacgcgatc cgcggcggcg ctagtgggca tcgaacgggc gataccctgc
      361 aatccctttt tataggcagg agccagatgc gcattggccg ccagcatggc gagagaatcc
      421 gacggggtta cgaaccggcc gcgtccgatg ataagattgc gatcgccatc gccatcggac
      481 gccgcgccga aatcaggcgc agtcgggctc atcataagat catacaactc gtgcgcatga
      541 acgggattgg ggtcgggatg atgtccgccg aaatcctcga gcggtgtgcc attgcgaacc
      601 gtccccttgg tgaaacccag acggttttct aaaatttcgg tcgcataggg tccggtcaca
      661 gcccccatcg catcgaagct catgctgaga ccaccggcaa ctgcggcccg gatggcatcg
      721 aagtcgaata attcctccat taaatcggca taatcggcca ccgggtcgat gatctcgatg
      781 cgcatatcgc cgatctgatt cgctcccaaa gtatcgagat cgatatccgg tgcatcgacg
      841 atgtaccaac gatcgatttc aaccgtacga gcgtaaatgg cttcggtcac cgcttccggg
      901 gcggggccgc cgttcgcgat attatacttg attccgaagt ccccctgcgg accgccggga
      961 ttgtggctcg ccgagagaac gaggccgccc gaagcgccat atttacgaat gatgtggctc
     1021 gttgcggggg tggaaagaat acctccgcgc ccgaccagga cacggccata tccgttcccg
     1081 gcggccattc gcatggcttg ttgaatcacg gtccggttgt gaaagcgacc gtccccaccg
     1141 atcacgagcg tggcgtcgct gctcggcttg accacgtcga acacggactg aagaaagttc
     1201 tctgcatagg aaggctgctg gaagaccgtt acctttttcc gcagcccgga cgttcccgga
     1261 cgctgccctt cgataggggt cgtggtcatg gtgcgccgca tagtctttcc ttttctgccc
     1321 gattgttacg ggttttcgca aatcggcaca ggcaatgcca caagttcgcg aaaattgtgt
     1381 ttcaaagttg gctttgtcca aagcggtcca acgttatcgc gcaatggtct cgcgcggcta
     1441 actatcttgc acgcgccacg atcctatcgg actttgtcgc atgcgtgctt cccttcggtt
     1501 ttcaaaggcg gagctgtcac ggttcagagg gaacagacag atccgccctc atcgatgtgg
     1561 gcgtatcgga atagatgcgg agcatgtgca aggttttaca aaatgattta accgtgcact
     1621 gaacagccgt aaccccgcac taccgaggcg ctgcattccg gagcgcgaca agattgacag
     1681 gtgccttatc gaaccgttcc actcaaccga tgatctcgtc agcgtggtcg taccatctta
     1741 caatgccgct gcgacacttg atgagacgct tctgagcatt cgcgagcaaa gccacagaaa
     1801 cctcgagatt atcgtcgtcg atgatggctc gaaggacaat acccgcgacg tggcggaaag
     1861 gcaggctgct attgacccga ggatacgtgt ggtcacgcag gaaaacggcg gggtcgcggc
     1921 ggcgcgtaac cacggtatcg aactggcaaa aggagagttc atcgcaccgg tcgatgcgga
     1981 tgatttgtgg cgcccgcgta agatcgaacg tcaattgcgc gccatgcatt ccgcgggtcc
     2041 atatacgggc ctcgtttatt gctggagcgc ggtcattgac gaggaaagca gcgtcatctc
     2101 acgggccaat tcgccctccc acgccggcga tgttttgccg cagctattct atggaaattt
     2161 cgtcggcaat ggcagttctg cattgatgcg caaagatctg gtacagggcg tcggcggctt
     2221 cgatccgtca cttcgtgctc gaaaggcgca agggtgcgaa gattggaaac tttacctttt
     2281 gcttgccgaa cgcagccatt ttgccgtcat accggactac ctcgtaggtt atcggtccac
     2341 ggctgcggca atgtctggcg acgtttccca aatgttgcgt tcggatgcga tcgtgcgcgg
     2401 ggaaatggcc gtgcgccatc ccaactcgcg cctcgaactg gagtgggggc ggcgccatta
     2461 tctcgaatgg atgctttggc gtgagctcga tgccctgaac tggcagaact gcatgacctt
     2521 gatccacgaa cgccgcgccg aatcgcgccc gttacgcatg gtggcgaggc gcgccaaact
     2581 tggtgcgaag ttctttcgac agaaaatgcg caggaagtcc ggttcggtcg tgggtgcgcc
     2641 gtttctggaa aatggagtga ccgcggatgc agggctcacc ctgccgttcg gttcaccgtc
     2701 ggggaatatc ggatgactcc gcgggcggcg cgggcatttg cctgttccga atgaagaacc
     2761 atattccagc ggccgcaccc ttgatctgct cggcaaggaa gcggtttttg ttggtcaagc
     2821 cattcttcag acggttagcg agaaggccca gatagtattt aggaagcaga acaaacgcgc
     2881 gccgtaggtt accggtctcc cccgttcgtt gatattgaac cataagcgcc gctgtatgcc
     2941 cgcgcatata gtgatagatc tgactggcca atcccgacat ctccagacga tgatgatgaa
     3001 acatcaccgc caacggttcg tagcggcaga tataacctgc ggcgagtata cggtaccaaa
     3061 actcggagtc gcccgaacaa cccgcctgtc cgacatctag cctctcgtcg aaatagccga
     3121 cacggtcgaa tatgatccgg cgaaaggcca tgttcgcgcc ggcaccgacg atccacgcag
     3181 ggcaaccata tctgccattc tgagaaaaaa aatcgtagcc ataatcgata cggtcgaacc
     3241 cgcgcccgaa actccattcg gtttcgaata tccattgcgc ttcggtatcg agacgggcgg
     3301 gcagaacaag gcccgtcacg gccatgatgt cgggtgcatc gaacgcggcg atcgtgctct
     3361 cgacccaccg ttcgtgaagt tcggtatcgt catcggtata aagcacaata tcgccgtgcg
     3421 ccgcgcgcgc cccgctgttg cgcgcaaagt cgagcccggg tcggtcctca cggatatagg
     3481 ttgccccggc ggacaatacg acgtcccggg tccgttgatc gcgagaggcg ttgtcaacta
     3541 cgatcaattc gtcgggtgtc cagctttgat cggcaaagct tgccagacac cgacgcaatt
     3601 cttctgggcg gtctcgggtg cagatcacca cgcttgtcga atagccggcg gacgcgcgaa
     3661 tcggtcgctc gcgccgtgcc tcgatacgcg cggcaatctc ctcggatggg tcagcttgct
     3721 cgcctggctt cagccattgt tgaccggccg gcagaccgtc tgcttcgaaa atgaccagag
     3781 ccggtcgccc cgccacaatt ggcgacgcct tgtcgatcgg tgagcgaaag atgtcggcaa
     3841 atggttcgat ggattggcaa ctttgtattg ccgatggatc ggaatgtgcc ggagagcgtt
     3901 gcatcaaatc tgtcctgaca atgaaggcac atgcaatcca taggggggca tgctggatac
     3961 agcaagcaag gccgggcggg tccttttgcc agagcagtga acctactgag aggggtggcg
     4021 gtaagcagcc ttggagtgct ctcatgcagc gaacaaactt gatcatccgc acttttcgct
     4081 tacgtttaga aacgcagcca tttggtgtgg attgcttggc gtagaagatc tcttttaccc
     4141 tacacgaagg tcatacataa tggggggcat atctcctgac ttgaagatgc gccttaacca
     4201 ttggaaagac gttgtcttgc ttttggtcag cagggacttt cgcggtcgtt acaagcatac
     4261 gaaagtcggc atactttggt cacttgccag cccaatcatg ttcttgctga ttttctattt
     4321 tctgtttcag cgtgtcatta atctcgatat tccccgctac gcatcttatg cgtttacagg
     4381 gattatcgtg tggaactgga cgcaacaggc tcttatcgct tcggtcacca gcatatcggc
     4441 caatcaggga ctcgtcgcgc aacccggctt tcctgtcgcg gcgctaccgg tgatatcggt
     4501 attatctgca ctgctcaatc tcgcgatcgc attcccgctt cttctcgcgc tctcctggat
     4561 tgacggcgcg acgccaactt ttgtgctgat cgctctgccg gtcgtgatca tcgcgcagtt
     4621 tcttttcatc ctctcggttg cgtacatcat cgcggccctc aatgtcggcc tgcgcgatgt
     4681 ggagcagatt ctgccgatca tcttgcaact gggatattac gtcacgccga tctttttttc
     4741 cttgcaaaac gtgccgccgg attttcacgt catgtttcgg tttaatccga tgacgtgggt
     4801 catttcgtcc tatcgcgata tcgttatgta cggcatttgg ccgaattgga ccgcacttgg
     4861 catcatcacg gcggggtcct gcctgttcct cgtgttcggc gtccggatat tcagccgtgc
     4921 gcgctatcgt ttcctagagg agctttgatg agcggctcgg tcgaagttcg cgatctgggc
     4981 aagcgtttcg cgcgctatga cggtccgcgc gccagttcga tcagggaagc catgcggcgc
     5041 ggctttcgtg ctgcgaaggt ttccgatcat ttctgggcgg tccgcgacgt cagttttcag
     5101 gtgaagccgg gagagatgct cgggatcatc ggtcataacg gcagcggcaa atcgacgatg
     5161 ctgcggatcg ttggcggcgt catgcgggcc gatacaggtt cggtcgtgac cacgggaagc
     5221 ataagcggcc ttctcgagct gaatgctggc atgcatcagg aacttagtgg gcgcgacaac
     5281 gtgctaatcg gcggcgtaat tgccgggctg acccgcagac agatcgccgc gcgcatggat
     5341 gaaataattg cctttgccga actggaagat ttcatcgaca gccctgtgcg cacctacagc
     5401 gcgggcatgc gtctgcgcct cggcttttcg gttgcgatcc ataccgatcc cggcgtcttg
     5461 ctgatcgacg aggtcctgtc ggtgggcgac cttgcgtttc aggccaaatg ccttgaccgt
     5521 attcgccgcc atcgcgacga aggatcggcc atcattttga tcacgcacga tctttcccaa
     5581 gttgagaaac tttgcaccga cgccctttgg ttgcgaaagg gagaagtcgt tgcgcacggc
     5641 ccgcctgatg tcctgagcgg tgagtatcgc gcggccatgg cgcagcaaac ccgagagcgg
     5701 acatattccg aaatgcccga tgagattagc acggggggca tcgtgttacg cgcgcatgaa
     5761 aatcgatttg gttcgctcga gaagaaaatc gatgcggtaa gcctgcggga ccgttcggaa
     5821 gctatcgtcg atgcaatcga aacgggcgcg cccctttcca tcgaagtctg tttcaccgaa
     5881 ggaggcattt cggaaccgat cgtcagcgtc acgatcgcaa cggcagagga aatcaaatgc
     5941 ctcgacgtaa atacagaggc cgacgaggcc attttaaatg atacgggcaa gaagggcgtg
     6001 gtccgcctcg aactcgaccg tgtcgatctc gccgcgggcc gctatttcgt cagcgtcggg
     6061 atatttcccg ctggctggga atacgcttat gactaccatt ggcatgctta ccccttgaac
     6121 attaccggct cgaccgagga tgtgggcaaa ttatcgccac cacgacgctg gacgacaaat
     6181 gcgcttgagg aataagagcg caaacggttc ctttcggcag aacctcgcta tgcaacatat
     6241 cgataacggg gaaaggccag acaagagcag ctgcgagggg gaaaagagca atttgctatg
     6301 cgcgaaccgg gcgctcgttc cagtggttga ggctctaccc ccttgtaaat ggcagccggc
     6361 atgagcccac tgcccccctc acagcccaat gccgacgatc atcgttctga acgcctcatc
     6421 tcggtcatca ttccagctta taacagcgca gacacgttaa ccgatacgct gaacagcgtt
     6481 cttgcgcaga catacagcct tatcgaggtg atcgtggtcg acgatgggtc gacagataat
     6541 acattcaata ttgcacggga gcatgccgcg tcggacccgc gtgtgcgggt tattcaacag
     6601 gccaatggcg gcgttgccaa ggcccgcaac acggcgatca gcgtaagcac ggcggatctg
     6661 attgcgccca ttgacgccga cgatctttgg caccctgcca agctggagcg ccagttggat
     6721 gtcttgaagg cgttcccgaa catcgggctc gtttacacct ggttcgccaa gatcgatcgc
     6781 caaggtcgaa ttatcgagtt cgaatcccgt cacacggcgg agggaaacgt tctcgcggaa
     6841 ttatgcgtcc acaacatcgt agggcacgcg agttcgcccc tcgtaacacg tgccgcgatc
     6901 gagcatgctg gcggttatga cgaaaccctg cgcgcgcgta acgcccaagg ctgcgaagac
     6961 aacaagctgt atctggcaat tgccgaacat tacaacttcg cggtggtgaa ggaacatctg
     7021 gtcggctacc gcgaaatgcc cgagggaatg tccagtgatt ttcaacagat gctgcgttcg
     7081 cgggacttgt gcataaagga aacggtcgac cgtcatcccg cccttgtcgc gattgcccgc
     7141 cgggggcgat ttcaaatgct caaatggatg cttcttcgcg cgttgcgtag ccggatgtac
     7201 agattgtcga gccaattgct gttcgaaatg ctccagactg ctcccacgtc aaccgccgcg
     7261 tatatcatgc gcttcgtctt caggcggctc accggcgctc gtcgagccac gcatgatcca
     7321 atggttggca aacccttcgt acaattgtgg tcggaatgat ccgcacctcg gtcggccacc
     7381 attaacattg ttaagatatg atcgatatcg ccaacttcca ctacgcgccc gccctgcttc
     7441 gcctccaggc caaagcggta tcgacaatcg tatcgatgtc ggagcattgc ggttgccagc
     7501 ccaatacccg ctgcgccttt tcatatgatg cgaccagagc cgccggatcg cccgcacgtc
     7561 ggccgcccat ctccaccgaa gggcgacgtc ccgctatgcg ttcgaccgcg gcaagcagtt
     7621 ccagtacggt tgtgccgacg cccgtgccca aattgaaaat atggcttcct tcgttggcaa
     7681 gtgcgaacgc gcccgccgcg acatgcgccg aggccagatc cgtgacatgg atgtaatcgc
     7741 gaacagcgct cccgtcgcgc gtatcgaaat cggtgcccat gaccgtaaac gtagcatccg
     7801 gatcgatggc ggcctcgatc gtgaggggaa tggcgtgtgt ttccggctca tgccgttcgc
     7861 caatctctcc gtccgcatcg gcccccgcgg cgttgaaata gcgcaatgcc acggtgcgca
     7921 gcccatgtgc cgcgccataa tcgcggagca tcttttctgc catgagcttc gattcgccat
     7981 agggattgat gggaacctgt ggatggtttt cgtcgatcgg cagatgctgc ggaataccgt
     8041 aggacgcgca cgtgctcgaa aacagtagcg gctttacctc gtactccagc atcgcatcga
     8101 gcatgttgat cgtaccgacg caattgttcc gataatagat ttcagggcta gcaacggatt
     8161 cgccgacata ggcgaatgcg gcaaaatggg cgataagatc gggccgcgta tcccgaaccg
     8221 cggcgctaat ctcgctccgg ttcagcagat ccccctcaat caacgggccc catttcactg
     8281 cgtcgcgcca gccgcgtgaa agattatcga aacagactac gcgccagcct gcggcagcga
     8341 aagccttgca acaatgtgag ccgacgtaac cggcaccgcc gatcaccaga accgttctca
     8401 tgatacgcgc tcatcgcgtt ttgaggtcag atttgccgcg ctgtcctcac cgatcgcgcc
     8461 cttttcgcgc aagaagccat cgaaatatgc gatcgtcttg acgaggcctt cgcgaagctt
     8521 gacttttggc tcccaattaa gcgcgtcttt cgccagcgaa atgtcgggct gacgttgctt
     8581 cggatcgttc acgggtaaag ccttatgcac gatctccgat cgcgaattcg tcaattcgat
     8641 gaccagttcg gcgagttcgc caatcgtgaa ttcgttcggg tttccaatat ttaccggtcc
     8701 ggtcatatcc gcggggctgt gcatcatggc gataaaccca tcgatcagat catcgacata
     8761 acagaaagag cgagtttgcg ttccatcccc gtagatagtg atgggctgac ccattaatgc
     8821 ctgcacaata aaattcgaaa ccacgcgccc gtcgtcgggg cgcattcgcg gaccataggt
     8881 attgaagatt cgcgcgacct tgatcttcaa ctggaactgg cgccagtaat cgaaaaacag
     8941 tgtttcggca caacgcttgc cttcgtcgta acacgaacgc ggtccgatcg ggttgacgtg
     9001 cccccaataa tcttcgcgct gaggatgcac gagcgggtca ccatacactt cagatgtcga
     9061 agcctggaaa attcgcgcct tggtacgttt ggcaaggcca agcatattga tggcaccatg
     9121 gacgctcgtc tttgtcgtcg ataccggatc atattgatag tgaacagggc ttgccggaca
     9181 cgccagattg tagatttcat cgacttcgag ataaagcggg atcgtaacgt catgtctgag
     9241 cacttcgaag ttcggattgc tcatcagatg ggcaatattt tgcttccggc ccgtgaaaaa
     9301 attatcgaca cagacgacat ctcggccgtc ttcaatcaag cgttcacaca gaaacgatcc
     9361 caaaaaaccg gcgccgcctg taaccaatgc acgttgctga acttcaacag ccatagttga
     9421 tcctgtcacc catttaggag cgaatatcgc ccgatatcat ggaaataaaa agagaaatct
     9481 ttgcttttta cggcggcgga atgcggcccc cgcgcgcagg tatctcgcct gtgttttctc
     9541 cacccggggt cagacgaaca aaactaaaat tacctcgaaa atcactgccc tgacggggga
     9601 ttgggaccgc gtatggccgt cgccaaacaa ggacccccaa gcattaacca tttgttaaca
     9661 tggttaacgc aaatgctgca cttgctaagg gttgtaccga ggctagcacg atggagattg
     9721 ttatgacgga taaaagcacg tatgtttcgc ctgttttgga aatgattggc tccttcgagg
     9781 agctcacgat gggcaattcc tcgggcgcga ctctcgactt cgatttcccg gtgggcactc
     9841 ccgacggcga gctgaccttg tcgtaattct ttcggctccg ccatggtgca ttggccatgg
     9901 cggagccatt tgcccaatct cgggctaggc ggagactgct ttgtcgaatg gttttactgt
     9961 aaactcctct gtaaccacgg cggagcttga atcgtccctc gtggtccttg acctctcgtc
    10021 gaatgcctat ttcaggttaa acgagatggg catcgagatc tggcgcaaga tcgaggatgg
    10081 cgcggacgaa gaaagcatcg tcgatgatct caccaacaaa tacgacgccg aacgcagcca
    10141 gatcgcaggc gatgtccgcg ggtttatcga agggctggaa acggcggggc tgatcgtaag
    10201 cggacgtgtc gaaaacagcc aatagtcgcc ttcgccgact tttcctcaat gaagtcacgt
    10261 tgctggcctt tgccatcccg tgcggctttc tgatcgggct ggccgttcgc atgggccggt
    10321 ttgagatggt gcaccgattt ttgcccaatg gccccggcaa atcgcaggcg accgctcgag
    10381 aagtgacgat cgttcagcgt gcggttcggc gcgcaattcg cctgtccccg agcgaaacct
    10441 gtctttccca agcatcgctt ggaaaaatac tcatgaatct tctcgaccgg caatccgttc
    10501 tgcatgtcgg cgttcgtctt ggcgaagaca acacggttcg cgcccatgca tggctttcgg
    10561 ttcgaggaat taccatggtc ggtggtcccg atgccaagat cgctcctttt cgccagatcg
    10621 ccgaattcgt atgagcggac ttgccggaat catcggcgag catggagctg aagcgcttca
    10681 gcgccgtgca ggtcggatgg tgtcggcagt cgcttatcgc ggcacgcctg cggtcaggat
    10741 gctcgacgct gacaagggca tccttgcgca actcggtcac acggcggcgt tcgacggtct
    10801 tcatatcgcg gatcgcgcaa tcgtcggcct gtccgggcgg ctggacgatc cggatgtgct
    10861 ggctacaacg cttggtctcg atgcgacccc atccgatgaa gtgctggtct atcgcgccta
    10921 tctgcgctgg gggaccgatt ttgtcgaata tatccagggt gaatacgcga tcttcctgtg
    10981 ggacagggta gaggcgaacc tcgttctggt gcgggatcgt ttcggcgtgg aaccgctcta
    11041 ctacgcaaac accagttcct cgtttgtgtt cgcgtccgaa ataaaggcga tcttggccgc
    11101 cgaacccgat cttcggggtg cgctgcgcga agatctgatc gtggattaca tcgccaatat
    11161 tcatgcggcg gaaccggaac agacgatctt caaacaaatc ctgcgcgtac cggccgcatc
    11221 catcgtaatg atacgtggac gcgagatcat cgtccgccgc tattataccc tagacacaac
    11281 cgtgcgatcg tgcgggaagg acgcgcccga acggttcgcc gaacgcctct cgatcgcggt
    11341 tcgccgccgc atgcgcgcga acggggaaat aggcgctttg ctgagcgggg ggctggattc
    11401 gtcgtcaatc accagccttg cagcgcgcga agttcgcggc ggacgggaac tcccgactta
    11461 tacgtcattc tataaagacg atcccgacgg agaggacccc tacgccgatg cggtccggcg
    11521 caaatacggc ctctcgcatc cggtgcttat agacgctgat gatatcaatg tcttcgacga
    11581 tttatcgacg cggctcaggg cgctggatcg gccgccttac ggacccaaca atgcccttgc
    11641 acaacatgtg gcgcgcagtg tggcggcaac tggaaccgct caggtcattc tttgcggtca
    11701 tggcggtgac gaaatcgtgt cgtcaggctc ttccttcctg cgtgagctgg cacaggcgaa
    11761 gcaatggagc cgcctctggt ccgaaattgg tgacaccgat gtcctaggtt ttccgagagc
    11821 gagggtattt agagatctgt tccttgctag ttcgccaatg gcgcgcaggg cggcgcggtt
    11881 cgtgcggatg cttaatcccg cgccaaaagc acctgtagca tcgtcatgga tgcaatatgt
    11941 gtccccccgc gtggccgacg cggctgcgtt ctcgcagcgg tatgacgcgg cgcgtacccc
    12001 ctcatctgat gtgaggctcc ccctgtccgc gcgcagccat atcgccaatc tctttaatcc
    12061 gatgcaggtc gaggcgtttg aaggcctgga tcaaacccgt acgccgagcg ggcttctttt
    12121 ccgttatcca ttttgggata aggatcttat cgagctggca atttcgctgc cgggggagga
    12181 gaaatggtcg cgcggctggc cacgggttct cctgcgccgc gcgatgaagg gaatactccc
    12241 ggaagaggtc gcatggcggc cggataaata taattacgta ttccgtttca aagatagcct
    12301 gcgcagagcg gaatccgttg cattaatttc gcatgcgctg aacgaggacg ccgagcgagt
    12361 ttcgcactat gttaacataa gtcatgcccg cggattgctg cacgacttgc agaccggcga
    12421 gatcggcccg ctcgatctgt tctatctttg gcgcgtgaca atcctaagcc actggcttga
    12481 ggaaagagat cgatgacgga tatgcagaga ggccttacac agaggcgccc tattcaaaac
    12541 gcgtatttct accaatgctt cgggttgcgc atcagatcgg atatcgcgtt tgccgaactc
    12601 gaccccgcac ctgaaggcga tgtggatctt tacattaggc tcggccccga gctcgatcct
    12661 gaggaattgc aagccgcgat cgaaaatcgg cgttccgacg gatcggaatt tttaggtaag
    12721 cgcatggatt tcggcgccgt tggccgatac gatatcacgg atgataccat cacgatttca
    12781 cccgtgatcg gcattcgtca ccccgatctc agccttcctt tgctcggccc ggttctggcg
    12841 acgtacttgc atcggcgcgg aatgctcata ctgcatggca atgcggtatt gctgaaggac
    12901 gggctgaccg tttttgtcgg cgatagcgga gcgggcaagt cgacgaccgg cgggtggttc
    12961 gcgtcgaatg tcggaacctt gtttaccgac gacatcctcc ccgtgcgtat cgcggcagat
    13021 ggtactcctt gggtggagcc cggttatgcc ctcgtcaagc tgagcagcgc agcagtcgag
    13081 gcgttcgcgc ctgccgatgc gaaaatcctg ccggtcagtt tcgaaggtta ccccaaactt
    13141 cgcgtccggc tttcaaggcc cgccatgccg caaaccagta caataaggcg aatctgcgtc
    13201 ctgcgtcgcg gcgaagaggc ggggtatgaa aggctgaacg attttgcagg gttccgcgcg
    13261 atggtcgaac atacctacat ggccaaatat cgcgatgcct tcaccagcgc cgaacgcaaa
    13321 gcgcttcatt taaagcaatg cagcgccgtt tcgcgcaacg tggaaatcgc cattctgacc
    13381 gttcctttcg gcatcgaccg gctgcacgaa gtcctatcgg tgcttgaggc tgcggagtga
    13441 gaccaggcaa gttcgtctcg ggctggcttg gtgttctgcg gcgtatggcc gccccggaac
    13501 cgaagcggct tgtccttacg ctgggattga cgctgatcgt ggcgctgacc gagaatatca
    13561 cgatcggcct gctgatcccg ctcatcacct atgcggagcc gggggctgca ttactgaccc
    13621 tcccgctccc cggaaaggtg tccgatttcg ccggtaacag cgagttacaa atccatatcg
    13681 gcgtggtgct ggcgatattg atcgcactgg tgatcgtgcg agtgctcgta cagcgaagct
    13741 cggatctgcg cacctccgcg cttatcaccc gttttgtacg gcgaacgcgg ttttcccttt
    13801 tcacggcgat cagccagacc cggtggagcg tactcgcctc gcaaagaacg gccgatttgc
    13861 atcacaatct gacggccgag gtcgatcgcc tcagtgcgct ggcttattcc tcgctatccg
    13921 ctacgaaagc ggcgatcatt gtggcgatct atctggccgt agcatgcctg atatcaccgt
    13981 tcctgaccgt ggtggcattg tccttggccg ggttgatctt cttgatgcag gtgccgctcc
    14041 acaaaaaggt gcgcgccagc gggcagcggt cgctcgacat cagaacgggg caaacccgca
    14101 ccgtttcgga cttcctgtcc tctctgaagg tgaataaggc gttttcgctc gagccgcgct
    14161 atgcccgcac actcgacgat ctgatgatcg agcaggaaga aaccgtgcgc gcctatgtaa
    14221 gtctgcaggg ccgggtgaac ctgatcgtgc aatccgccat gattatcggg ctttcgcttt
    14281 tcgtttatac atcgctcgta gtcgcggaaa cgacacaggc cgaagtgctc atcattctct
    14341 tgctgttctt ccgattaagt gggcgcaccc aagccatcca gacggctctt cgcgaaatag
    14401 aatccaatgc gccctgtctc gaaagactgg acgggatgat cgcgcaatac tcgatggatg
    14461 aggaggagcc tgtctcggcg gtggtggatg cgccacgcct gcaccacgaa atgcgtttcg
    14521 atggcgtggt gctgacctac gccggggcga aggcgcccgc cctcgacggg gtgtcccttg
    14581 tcattcccgc tcgcaagcta accgcgctgg tcgggcgtac gggtagcggc aagaccacaa
    14641 ttgcggacct ggcgctgggc ctcctttcaa ctgatagcgg cagtcttacc atcgacgggg
    14701 tgacgctagg caatgacaat cgccgggcat ggcgtgaata tgtctcactg gtgccgcaag
    14761 atccggtgct gtttcatggt tcgatccgcg aaaacctcca tctggttcgc cccgatgcca
    14821 ccgatgccga aatggaggag gcgctggaga cagcgcatat actcgccacg atcaggcgtc
    14881 tgccgcacgg gctcgatact gcggtgggcg atcgcggcca gatgctgtct ggtggcgagc
    14941 gtcagcggct cgcgctcgca cgcgcattgc tacgcaagcc ggcattgctg gtgcttgacg
    15001 aagcaaccag cgcgctggac tcggtcaccg aagctgaggt ggtgagggcg ctagccgata
    15061 tcaggcacga aacaagcatt ctggcaatta cgcataggcc cgccctcctc gacgttgccg
    15121 accatgtcgt gctgctgcgc gatggccgca ttgtcgaaga agggacgaaa aaactgtccc
    15181 tggacgctct gtacgcgtcg gaataagcgg aataccgcgc ccccgcttca attttacgcg
    15241 tataggcttg ggaacgtccg ttccgcgcat ttgcgccagg aaaagtcctt cgcccgcctg
    15301 caggccgctt cgcccatcgt cgcttcggct tgcggctcgc gagtgatgcg cagaactgcc
    15361 gatgcgagtt cctcaatatt atccggctcg accagcaagc cggtatcggc aacgacctcc
    15421 ggaataccgc cggttttcgc ggcgatggac gggcatttct gcgctgccgc ctccagcagg
    15481 actagaccga aaccctccac ctttcccggc agtgggcgcg caaagagcag atgcgcggtc
    15541 gaacggcgat agacgcgctt cacatcgtcc atagacaatt tgccagtgag aatcgtgcgc
    15601 agcttgtatt tgcgcgcctc gcccatgatc gcgtcggcgt aggcctgatc ttccgcgcgg
    15661 ccgaccacga catagaccgg atcgtccatg ctcagacggt cccgcgcgaa tgcgagggcg
    15721 cgcaccgttt cgatctgtcc cttacgcggc tcgagccttc cgaccgaaca gaaaaccttg
    15781 gcttccggcg gtatttcggc aagcgcctca tgctcgaacg cggaagagag cggatcctcg
    15841 aaccaagcat cgtcaacacc gagataggtc acagtgtcgc ttttgggttg ccccacctgt
    15901 gcgcggaaga tcgcaccggt cgcctctgaa ttgtagagaa cctggtccgc actcagatag
    15961 gcacgacgta ccagcttaaa caaaagcgac ccgtcgcgga acttgtgcgc ctcgctacca
    16021 tgaaccatca cgcgatacgg acgccgatgc agcggttgta gcaaatgcac gagcagtagg
    16081 gttcggatat ctgccgcaat caggaccgca tcgcgcggcg cgcggcgcaa tacgcgcagc
    16141 aatgtcgccg ccgctatcgg gcgaattcca tgatgcttca gaacgcggtg atattcgatg
    16201 ccggtcggct cgtctagatc ctgcccacca tcatatcttg gacagatcac gatcgtgcga
    16261 tgcccgtccg cggccaagac agcggcaaga cggcccgagt aggtaccgat cccgccggga
    16321 aaggggggat actcgcatgt gacgaggatg acagtgctag gcatgtgcta gtttactccc
    16381 aacgccgact ggcgttcgcg tcccgcgcgt cccagcattc gcaatgccag tccgggggca
    16441 accgatacgg ccacgagcga catccagctg cgacggttga acgggtgaag ccggacggca
    16501 aagcgcagcc ataaaagcgc accttcccga tcgttcaata aaaatcgatg atttccaagc
    16561 ttgcgcgctc gctcagccag tcgccgcggc acgaggggca gaagttccgg ctcattcgcc
    16621 gcggcacgca atgcgacaaa ggcatggtgc gccatcagat ccttgcggcc gccggtgatg
    16681 ctggtgttgc gattgcgctt gtacagcagg ggttcgtcga caaagcctag acgggcaacc
    16741 gctatgatac gaaggaaaaa atccgtatcc tcgaaaacct tgacctgtgg atcgaaaccg
    16801 cccgacgcgt cgtagcagtc ccgtcgtatc agggtggtcg acggaataat cggcggatcg
    16861 ttcagaaaat aggtaaccgg caagtcgccc gctttggaaa tgtcgatcgt gttggcaagc
    16921 agcgctcgat ccttgtcgaa atcggggaag gtgaagaaac gaccgtacac cattccgacc
    16981 tccggtcgtt cgtccaagat cggcacctgc aactccagct tgcgtttgac ccatatgtcg
    17041 tcgccatcaa ggatggcgat atagggcgag ctggtttcgg aaattgccca acaccgttgt
    17101 ccgggcaacc cggcgccccc ggacccgtaa aggacgcgga tacggtcgtc ccatcgctcg
    17161 atttcacgca aggttgccag ggtgtcatca tgcgaaccat catcggcgat gacgatttcc
    17221 cggatcaggt cggcccggct ctggtcgaga atgctgcgaa ccgcctcgcc tatataaggc
    17281 ccttcgttgt agcaggtcag gatggctgcg actggtgcct gcgatcgctc ggtcatctca
    17341 ccccttaaac ataaattcac aacgcaaagc ctcggacccg gcacaagcta atctgccatt
    17401 ctgcatgcgc agcacaatgc tgcattgcaa caaagtccta cctctaaccg tttccattat
    17461 taactccaag ccctctgaac gctttgaccg tacagttaaa actgaaaact tttcagcaag
    17521 gtcagcgtaa tcgcgttcga ggtaatatca tccgcaatcg tgctgtcgtc gatcaagacc
    17581 ctgcttgcag aaagcgcagc attgatcccg gagcccaatt cgtaattcaa tccggcctga
    17641 aggacccaga acttgtcagt tcgattcatg ctgtcttcga ggccattgcg gggcagaaag
    17701 cgaaattcgc gttccgcccg ctcgatgccg gcattgaacc ccagtcgacc ataggccgtg
    17761 ccgctcactc caagcgagta gctgttgagc accacgccat tcgagaacaa ctcgtcattg
    17821 ctggaaaagg accgcaccgc acgggccgcg atgttgagcg aacgtaatgg cgcccagctg
    17881 gctgcgacat tatacgtcaa tccttgataa tcgatgtcgc gcggagaacg gtcgtcatgc
    17941 caagtatacc ccacccgccc gcttagcgaa taggtgaccg gcgccgtcca tatgatttcg
    18001 gcatagacac cttcgctgct tgcctctggc gaatagagaa tcggatcacc gccgatcagg
    18061 acggtgcgaa gaccatcgcc ttcacttcgc gattgggagt atcccacgcc gatacggttc
    18121 ttgatcgggg agacatattc gattccagct gaataagcgt aaatcgtatt attgacccca
    18181 cgtaagtccg accctggact ggagctcgac gacacccgcg cggaaccggc tacgtgaaaa
    18241 tctgaaagaa ttcgccggtc gccgcgaacg ctgaaccgtt ctaggctgcg aatgttggtt
    18301 ccacgaaaca agggatcgct aaaactcagg ttttgacggc tcaacatggc atcaaactgc
    18361 gccgacccac tttccgccag atattgggtc cgcccagcga gacgatattc ttccgaatta
    18421 aattggctgt tattggcgta aaaccgtccg ccaatatcac cattcaccgt gatatcgaat
    18481 agcgatattc gcgtgttata ttccagattt gcgccgacaa acgtactgaa ttcatccgac
    18541 ggatctaccg cgtctttttg atcgtcagtt agttggaaca gattgtcgtc gtaaacagtg
    18601 agtactttta aagaaatctc tcgggactgt gaccatgcct gctgcgatgc aggcagcgtt
    18661 ccgaacgcgc ccgacaatag cagaagaaaa aagccccgta tccgggacaa ggacgacgac
    18721 cattttttgg tttccgagtg gagagagccg tgcgttttca ttgccgagcc ttatgtttgt
    18781 ttgtttccga tcgccaaatg gcagaccgga ccattgtctg ttttcagcag agcgaccgtg
    18841 tgcggtcaaa ctgacgaata agtaatgtct ggttaaggga cattgggaag ggggatggcg
    18901 caggtgcggc actattcgga gtagtagtcc tcataccaat ccacgaagcg acgcactccc
    18961 tcgcgaacgt cggtctgcgg tcgatagccg gtcaactcga aaagcagcga ggaatcagcc
    19021 caggtcgcag gtacatctcc agcttgcata tccatatagt tacgcaccgc cggcttgccg
    19081 atcgcctgtt caagcgcatc gatgaaatcc tcgagtcgga ccgaatcgcc attgccaata
    19141 ttgacgattc ggaatggcgc agcggcggac aggctatcgc cttgcgcaat atcctgccgg
    19201 ctgtccggac gtttgggcgg aacgtcgatc aacaggcgga tgccccgcac cagatcctca
    19261 acataggtga aatcgcgcca catctcgcca tgattgtaga tgtcgatagg cgtgccgtcc
    19321 ttgatcccct tggtaaattt gaacagcgcc atgtccggcc ttccgtaagg accgtagacg
    19381 gtgaaaaacc ggaacatagt cgtcggcaga ttccacagat gagcatagct gtgggccatg
    19441 gcttcgttcg ccttcttcgt ggcggcgtag atcgtcatgg gtgtgtcggc cttgtgcgtc
    19501 tcggcgtagg gcatttcttc gttggccccg taaaccgaag aggttgaagc catcagcaag
    19561 tgatcgaccg ccagttcgcg cgcgcactcc atgacattga atgtgccggt aatgtttgtt
    19621 tcaacatagg cgcgtggttc ttcgaggctg taacgcaccc cggcctgcgc cgcgagatga
    19681 acgataacct caggcgctgc ttggtccatg aatttacgca agcgcggata atcgaggaca
    19741 tcgaattcct cggcgctgaa ggcgttgctt tcgcgcaaga tggcatggcg acgctgctta
    19801 agcgcggtgt cataataatc ggtcatggaa tcgacaccga cgacacgaaa gccttcggca
    19861 ataagcagct tggcgagatg aaagccgatg aaacccgcag ttccggtgac catgacggtt
    19921 cgcatagcgg cttttcccct gatctaattt ggcatcgtgc gcccaagaga agatttcgat
    19981 ggctacaggg cctatatgca cctgcagcat gagagcaaag gccaaagtac cctgtcggca
    20041 gttggtttct taagcatcat cggataaacc gaacattgat atggcggatg cgtgcgtgaa
    20101 tttcatatcc gactgcagca tataaaggac agtgccagat gctgaataaa gcgacacgct
    20161 ttccatatgc gccatcaatg gaaagcgaga gcgcaggtta atgaagcagt cgatttttcg
    20221 tcgtcgcgca aagcaaatcc cacagtcggc gcgcaaccgt cattctatgt ttggaataag
    20281 gtccggcaag gaaagccgaa acttgttcgg aattctgctc gctgcgtttt tgtttttgct
    20341 tattggactc gcttacaaga tcgccatcct tcagactgta tcgatgctcg ttctggccac
    20401 aggtatttgg gctggacgcg atgccattgg ccgtgtgaat atggtgttcg ttcttgggct
    20461 gctctatatt gccagcgcga ccgtcagtgc ctttttggtg tcgacaggcg aaggcatgta
    20521 tcgcaccgcg caattttgca tcgtagcggg cggattgacg ggcatttatc tctattcctg
    20581 gcatcttggt gaggaacacg cgcttcgcgc gctaaagctc attgcgatcg tcagtgtcgc
    20641 gatcttcgcg catctcatca tctatcatct gtcgatcggg aaatatcaaa cgtggaaata
    20701 tctatctgat accaagaccg tgatatcatt gactgtcttt ctatgtttcg cgcttcagga
    20761 tgaaatccgg cgaagggtcc cttttccgat agtcatggcg gttcttgtct ggctgattgc
    20821 ggcaagtgcg gaaagaaaag cttttctgct gttcgtcata gcggcggctt tttcgaccct
    20881 aacctggcgg gcgaagatat ttctgtttgg ggggggaata ctcctaattc tccttgccgc
    20941 ctcgacgggg tgggacaacg gctatctcgc aaaccgattt caagcggctc cgatcgacgt
    21001 gacgacagtt tcggaccgct atttttcgac ctttcagaac atcggcgatt acagcgatct
    21061 ggtccgcgaa ttcgtcaatc gcaatgcttg gcagctcttc aaggacaatc cgtttctcgg
    21121 tgtaggcgcc accggttatc gcgcatgggc attcgaagtc ttcggcgcca cggactttgc
    21181 catgaacgtt catggcgagg tgcaccgtgt gccagcagag ggcgggattg tagggatagt
    21241 cattgcaatc gcctatcttg cggcgacgat ctggcgcgct tttcatttcg ccttcttgcg
    21301 ccccgaacga acgggaacag cacttgagcg tactccgctg cttctgtgcc tctatgtcat
    21361 gagttacgct tatgcggaag caattgacac ggggatgctg gttctgatcg gtgtcaacag
    21421 cgtggtcgcg gcaagattgc cggcgccgtc gttaggaaat ctgatgcaaa gacgtcttcg
    21481 caggagcggg agacggactc ctcggcgcaa tacacggggc gcggggaaga gggaccccct
    21541 gccaaattag gccgtgttca caaaagacct cgtccgtagg ttggctgcgg caaggttaag
    21601 ggagctctct gaggacagga cggtttta
//
