LOCUS       NZ_CP060140            20450 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Nodularia sphaerocarpa UHCC 0038 chromosome, complete genome.
ACCESSION   NZ_CP060140
VERSION     NZ_CP060140.1
KEYWORDS    RefSeq.
SOURCE      Nodularia sphaerocarpa UHCC 0038
  ORGANISM  Nodularia sphaerocarpa UHCC 0038
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales;
            Aphanizomenonaceae; Nodularia.
REFERENCE   1  (bases 1 to 5451672)
  AUTHORS   Ahmed,M.N., Wahlsten,M., Jokela,J., Nees,M., Stenman,U.H.,
            Alvarenga,D.O., Sivonen,K., Poso,A., Permi,P., Koistinen,H. and
            Fewer,D.P.
  TITLE     Suomilide, a new member of the aeruginosin family
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5451672)
  AUTHORS   Ahmed,M.N., Wahlsten,M., Jokela,J., Nees,M., Stenman,U.H.,
            Alvarenga,D.O., Sivonen,K., Poso,A., Permi,P., Koistinen,H. and
            Fewer,D.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-AUG-2020) Department of Food and Environmental
            Sciences, University of Helsinki, Viikinkaari 9, Helsinki FIN-00014,
            Finland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3; SPAdes v. 3.11.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 77.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022376295.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 07:15:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,556
            CDSs (total)                      :: 4,496
            Genes (coding)                    :: 4,450
            CDSs (with protein)               :: 4,450
            Genes (RNA)                       :: 60
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 46
            CDSs (without protein)            :: 46
            Pseudo Genes (ambiguous residues) :: 0 of 46
            Pseudo Genes (frameshifted)       :: 11 of 46
            Pseudo Genes (incomplete)         :: 34 of 46
            Pseudo Genes (internal stop)      :: 13 of 46
            Pseudo Genes (multiple problems)  :: 10 of 46
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:16:42
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4000963
            Orig. end                         :: 4021413
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP060140.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20450
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="14"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20450
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20450
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10450](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10450
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(332..345)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.57"
                     /tool="antismash"
     gene            complement(480..1025)
                     /locus_tag="BDGGKGIB_RS16435"
                     /old_locus_tag="BDGGKGIB_03326"
     CDS             complement(480..1025)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016874929.1"
                     /locus_tag="BDGGKGIB_RS16435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03326"
                     /product="oxidoreductase"
                     /protein_id="WP_239727986.1"
                     /transl_table=11
                     /translation="MSRLKLATVWLGGCSGCHMSFLDLDEWLIDLAAQVDLVYSPFADV
                     KEYPQGVDVVLVEGAIANEDHLQMIHIVRERSHILVSFGDCAVTGNVTALRNPLGSAEP
                     VLQRCYIETADIHGQIPHEPGIVPTLLDRVVPVHRIVPVDIYMPGCPPSATRIKATLEP
                     LLKGEKPQLEGRDMIKFG"
     gene            complement(1172..1912)
                     /gene="hoxU"
                     /locus_tag="BDGGKGIB_RS16440"
                     /old_locus_tag="BDGGKGIB_03327"
     CDS             complement(1172..1912)
                     /codon_start=1
                     /gene="hoxU"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer2_4"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010994936.1"
                     /locus_tag="BDGGKGIB_RS16440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03327"
                     /product="bidirectional hydrogenase complex protein HoxU"
                     /protein_id="WP_239727987.1"
                     /sec_met_domain="Fer2_4 (E-value: 1.4e-19, bitscore: 68.0,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVKTLSINERLVSGREEETVLQAAQDAGIYIPTLCHLQGVTDVG
                     ACRLCLVEIAGSNKLQPACVTKVTEGMEVKTDSDRLHRYRRTIIEMLFAEGNHICSVCV
                     ANGNCELQDLAIEMGMDHVRLDYHFPDRKVDVSHDRFGVDHNRCILCTRCIRVCDEIEG
                     AHTWDMAGRGTNSHIITDLNQPWGTSQTCTSCGKCVNACPTGALFDKGSSVGEMKRDGL
                     RPAKGDRAKLDFLVTAREKHQWNL"
     gene            complement(1974..3575)
                     /locus_tag="BDGGKGIB_RS16445"
                     /old_locus_tag="BDGGKGIB_03328"
     CDS             complement(1974..3575)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006195769.1"
                     /locus_tag="BDGGKGIB_RS16445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03328"
                     /product="NuoF family protein"
                     /protein_id="WP_239727988.1"
                     /transl_table=11
                     /translation="MDLAELKEIARKESDSQKPVQIRCCIAAACLATNSQAVKQRLEEA
                     VTAENLAEKVEVYGVGCMRLCCQGPLVQVERNTESESVNTLYEKVTPDDAPSIITALNG
                     GETAVSQSDLTHPFFTSQMSIVLENSGKIDPERIQSYIAAEGYQALYHVLREMTPTEVV
                     DAITRSGLRGRGGAGYPTGLKWATVAKAKGERKFVICNADEGDPGAFMDRSVLESDPHR
                     VLEGMAIAAYAVGANQGYIYIRAEYPVAISRLQIAIRQAQSFGILGSQIFDSRFDFKID
                     IRIGAGAYVCGEETALMASIEGKRGTPHPRPPYPAESGLWGYPTLINNVETYANVAPII
                     RKGAEWFASIGTEKSKGTKVFALAGKITNTGLIEVPMGTSLQQIVEVMGGGVPNGGVVK
                     AVQTGGPSGGCIPASAFDSPVDYESLTELGSIMGSGGMIVMDESTNMVDVARYFMEFCM
                     DESCGKCIPCRVGTVQLFNLLTRISEGEACLADLELLEELCDMVKHTSLCGLGQSAPNP
                     VFSTLRYFRDEYLELI"
     gene            complement(3562..4101)
                     /gene="hoxE"
                     /locus_tag="BDGGKGIB_RS16450"
                     /old_locus_tag="BDGGKGIB_03329"
     CDS             complement(3562..4101)
                     /codon_start=1
                     /gene="hoxE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006195770.1"
                     /locus_tag="BDGGKGIB_RS16450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03329"
                     /product="bidirectional hydrogenase complex protein HoxE"
                     /protein_id="WP_239732155.1"
                     /transl_table=11
                     /translation="MDLASAVKNNNQAKASSATDTQGDKRLKILSATIKRYQYQQDALI
                     EILHKAQELFGYLEKDVLVYIAHQLKLPPSTVYGVATFYHFFSLAPIGVHSCMVCTGTA
                     CYVKGAEEILNSLENSIHIRPGETSTDGQISLLTARCLGPCGIAPVVVFDDTVLGDQTP
                     ESVGECIKGWLQNGSS"
     gene            4445..5524
                     /locus_tag="BDGGKGIB_RS16455"
                     /old_locus_tag="BDGGKGIB_03330"
     CDS             4445..5524
                     /EC_number="2.7.1.11"
                     /GO_process="GO:0006002 - fructose 6-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016860266.1"
                     /locus_tag="BDGGKGIB_RS16455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03330"
                     /product="ATP-dependent 6-phosphofructokinase"
                     /protein_id="WP_239732157.1"
                     /transl_table=11
                     /translation="MQKRLGILTSGGDCPGLNAVIRAVVSHATLTYNWQVVGIPYATRG
                     LLERKAIPLSIHGLDLRGIDPLLNMGGTILGSINKGDTLAHAEEIIAGYHALELDALIG
                     IGGDGSLAILTQLQSLGNWQFVAIPKTIDNDVGQTERVVGFDTAVNTIVDALNRLTFTA
                     ASHDRVMIVEVMGRKAGHLALHSGIAGGADVILIPEIPYSIQGVCEHLAELRERWGRRF
                     AIIVVAEGAQIAVDSSTYSSCERPSCGMGQYIADEIGDCTQDQIDIRVSVLGHIQRGGI
                     PSALDRLMATAFGKAAVDLLADNQSAQMVAWQNGQVVAVPLEAVLASSPCLVDPDNFLV
                     QTARSLNIYMGNMTLGTTA"
     gene            5660..7060
                     /gene="mgtE"
                     /locus_tag="BDGGKGIB_RS16460"
                     /old_locus_tag="BDGGKGIB_03331"
     CDS             5660..7060
                     /GO_function="GO:0015095 - magnesium ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015693 - magnesium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mgtE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015115761.1"
                     /locus_tag="BDGGKGIB_RS16460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03331"
                     /product="magnesium transporter"
                     /protein_id="WP_239727989.1"
                     /transl_table=11
                     /translation="MTETNNLNFTTQNATRSELRDLVRNQLQILLEAGNLQEAKFILQP
                     VQPADIAEAIEGLPEAMHALVFRLLPKTEAIEVYEYLDYTVQEHLIEELRSQDVRDIVD
                     KMSPDDRARLFDELPAKVVNRLLEQLSPTERQATAQLLGYEADTAGRIMTPELIYLKEN
                     FTVSQAIERIRSLANVSEIIYYLYVTDGVRRLTGIVSLRELVVSQPEQTIGEIMTREVV
                     FVHTDTDQEEVAKLIQRYDFLAVPVVDKEQRLVGIVTVDDVIDILQQETTEDIYALGGG
                     VQSDGDNYFQMSLLQVARKRVVWLFVLLITNTVTGTIIKSQEDILKQAVILTAFIPLLT
                     GTGGNVGAQSSTVVIRGMSTDEIRSLKIWQIIGREAIAGAFLGLMLGSIATVWAYFLQG
                     RAEVAFTVGISLVAISIIASVSGSALPFLFRAFRLDPALMSAPFITTAVDVLGVLIYFS
                     LARVILGL"
     gene            complement(7261..7518)
                     /locus_tag="BDGGKGIB_RS16465"
                     /old_locus_tag="BDGGKGIB_03332"
     CDS             complement(7261..7518)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010999307.1"
                     /locus_tag="BDGGKGIB_RS16465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03332"
                     /product="hypothetical protein"
                     /protein_id="WP_239727990.1"
                     /transl_table=11
                     /translation="MTSAKPLLGTELVDCARANAKQGIETAAYQCGYGDDINTFASELR
                     NSCEKMNLQVKELNELITDQDMILELGSGEIVAPETASEL"
     gene            complement(7935..8789)
                     /locus_tag="BDGGKGIB_RS16470"
                     /old_locus_tag="BDGGKGIB_03333"
     CDS             complement(7935..8789)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (41-203). E-value: 6.6e-12.
                     Score: 37.6. Matches aSDomain:
                     nrpspksdomains_BDGGKGIB_RS16470_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017310770.1"
                     /locus_tag="BDGGKGIB_RS16470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03333"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_239727991.1"
                     /sec_met_domain="adh_short (E-value: 7.4e-34, bitscore:
                     115.3, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.1e-33, bitscore:
                     115.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEENLQPPQEQKPPGKESEMQPKPKADDPHYQGSGKLDNKVALI
                     TGGDSGIGRAVAIAFAKEGADVAIVYLNEHDDAKETKHLVEKQGRRVVAIAGDITDETF
                     CQQAVEQTVDEFGKLDILINNAAEQHPKENIEEISKEQLERTFRTNIFSMFYLTKAAMK
                     HLKAGSAIINSTSVTAYKGNPLLLDYSSTKGAIVAFTRSLSQNLVSQGIRVNAVAPGPI
                     WTPLIPSTFPADQVATFGKQVPMGRAGQPEEVAPSYVFLASDDASYMTGQVLHPNGGSI
                     VNG"
     aSDomain        complement(8181..8666)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BDGGKGIB_RS16470_PKS_KR.1"
                     /evalue="6.60E-12"
                     /label="BDGGKGIB_RS16470_PKS_KR.1"
                     /locus_tag="BDGGKGIB_RS16470"
                     /protein_end="203"
                     /protein_start="41"
                     /score="37.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALITGGDSGIGRAVAIAFAKEGADVAIVYLNEHDDAKETKHLVE
                     KQGRRVVAIAGDITDETFCQQAVEQTVDEFGKLDILINNAAEQHPKENIEEISKEQLER
                     TFRTNIFSMFYLTKAAMKHLKAGSAIINSTSVTAYKGNPLLLDYSSTKGAIVAFTRSL"
     CDS_motif       complement(8595..8660)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDGGKGIB_RS16470_0001"
                     /evalue="4.80E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="BDGGKGIB_RS16470"
                     /protein_end="65"
                     /protein_start="43"
                     /score="12.8"
                     /tool="antismash"
                     /translation="LITGGDSGIGRAVAIAFAKEGA"
     gene            9205..9867
                     /locus_tag="BDGGKGIB_RS16475"
                     /old_locus_tag="BDGGKGIB_03334"
     CDS             9205..9867
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006198196.1"
                     /locus_tag="BDGGKGIB_RS16475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03334"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_239727992.1"
                     /sec_met_domain="Methyltransf_3 (E-value: 2.1e-79,
                     bitscore: 263.6, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANQTLGIEPKLYNYLLSVSLREPEILSQLRKETAQHPMSEMQIA
                     PEQGQFMALLVQLIGAKKTLEVGVFTGYSSLAVALALPPEGRVVACDVSEEFTAIARRY
                     WQAAGVADKIDLHIAPAMETLDQLLAAGEAETFDFAFIDADKSNYDGYYERSLKLVRPG
                     GLIVIDNVLWSGKVADSEVQDNRTTKIRALNEKLHQDERINLSLVPIADGLTLAHKK"
     misc_feature    complement(9976..9996)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 23.16"
                     /tool="antismash"
     gene            10001..10450
                     /locus_tag="BDGGKGIB_RS16480"
                     /old_locus_tag="BDGGKGIB_03335"
     CDS             10001..10450
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129602.1"
                     /locus_tag="BDGGKGIB_RS16480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03335"
                     /product="PqqD family protein"
                     /protein_id="WP_239727994.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.7e-16,
                     bitscore: 58.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.2e-14, bitscore: 52.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENSQVFRVNSPQVVCETIDGEVVVVDLERGYYYSLLKTGADLWS
                     CIEGHLQRDDIIQEIGKKYDGTIEEITEAIDEFLDKLQHEGLIVADVTITPGAMNEQES
                     VTSTEKPKFEKPMLEKFTDMEDLLLLDPIHEVDVEAGWPKVKTVS"
     misc_feature    complement(10020..10039)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 22.63"
                     /tool="antismash"
     aSDomain        10028..10270
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BDGGKGIB_RS16480_Stand_Alone_Lasso_RR
                     E.1"
                     /evalue="1.10E-18"
                     /identifier="RREFam002.1"
                     /label="BDGGKGIB_RS16480"
                     /locus_tag="BDGGKGIB_RS16480"
                     /protein_end="90"
                     /protein_start="9"
                     /score="58.0"
                     /tool="antismash"
                     /translation="NSPQVVCETIDGEVVVVDLERGYYYSLLKTGADLWSCIEGHLQRD
                     DIIQEIGKKYDGTIEEITEAIDEFLDKLQHEGLIVA"
     gene            10475..11515
                     /locus_tag="BDGGKGIB_RS16485"
                     /old_locus_tag="BDGGKGIB_03336"
     CDS             10475..11515
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129601.1"
                     /locus_tag="BDGGKGIB_RS16485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03336"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_239727996.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 6.8e-11, bitscore:
                     40.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLNWSDGVAARQGLRLAYFDSYRLKLSHKQLLKATLLKEQAMLT
                     AWQDWRDSVDIETLDHSSYSLLPQLYQNLLAHKVDNADMARLKGIYRRHWYANQLKLKS
                     LTAILSSLKDIGIEAIVLGDAAWGGIGKNQIENYRPISSFHLLLDGNYLETAIEHLRSL
                     NWHSLDGSTQQFRELRNNCDSLNLRLYLQEHLFWAIPQDYTDGQVWHYATADWSHEAGW
                     RLSATDQFLDGCARMFFRQQPKSSNPQIHRIADALVLIANLENNDWIRLITQAQRYQMI
                     LPVRNMLQLLQQLFSVELPTWVLPALWQMPIANTEWLKYRVLDGDRRSLMRSTIVQSLQ
                     LLTFSK"
     gene            11546..12643
                     /locus_tag="BDGGKGIB_RS16490"
                     /old_locus_tag="BDGGKGIB_03337"
     CDS             11546..12643
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129600.1"
                     /locus_tag="BDGGKGIB_RS16490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03337"
                     /product="serine kinase"
                     /protein_id="WP_239727997.1"
                     /transl_table=11
                     /translation="MYPNPDRSIAQSDRLAYFQLVYTGFERAAQIAGEVQYFYAIGKYN
                     LCLRFAGEGLIPQITPALSHLSIAPVPQPDLTICLWDNTSTKTQLPLLIDSLLTLIRLH
                     WTDYLGPRKEIKAYDGDRIRSNFHIGPNILSVLDREQNLACYWIDNAEDIPYWEKGSPL
                     QTILNWWTSDHRQHQYVHAGAIGNPDGGVLLAGKGGSGKSSTALTCINSSLLYASDDYC
                     LVTSDPQPYVYSLYNTAKLKGQADLERFPHLADLIDNCDRSENEKAMLFLHQHHPEKVV
                     QGFPIKAVLVPQITGKLDTHLRPISAGAALRALAPSTIFQLAGSGQTALKIMSSLVKQV
                     PCYVLELGTDMVQIPDVIQRLLSQI"
     gene            12675..13400
                     /locus_tag="BDGGKGIB_RS16495"
                     /old_locus_tag="BDGGKGIB_03338"
     CDS             12675..13400
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016908.4"
                     /locus_tag="BDGGKGIB_RS16495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03338"
                     /product="FkbM family methyltransferase"
                     /protein_id="WP_239727999.1"
                     /transl_table=11
                     /translation="MGYLRRKMIEGLTRFVPTILPPQRQYYNETNNDRWICEYVFPNKR
                     DGYFLEVGAANGKQASSCYVLEKEFGWKGICVEPSDYFFEQLVRNRPNSICEQVCLSNQ
                     VGTVTYIEGSDETVSPYLSGIKSNLETVKYQGKEVVAKGKEVKKEAVTLEVLLKKYHAP
                     QVIDYAAFDIEGSELDVLEVFPFESYVFLALSLECDSSIRLPISQLLESNGYRRAKNPF
                     NRDKPWEMYWLHQSVYKRL"
     gene            13454..14146
                     /locus_tag="BDGGKGIB_RS16500"
                     /old_locus_tag="BDGGKGIB_03339"
     CDS             13454..14146
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129598.1"
                     /locus_tag="BDGGKGIB_RS16500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03339"
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_239728001.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.5e-39,
                     bitscore: 132.9, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLPLVTVIIPVYNYANYIAATLDSVFAQTYRPIEVIVVDDGST
                     DNSAEIVRAYPEVQYFYQSNQGVSVARNVAIAAAKGEFLAFLDADDLWKPDKLSLQIAY
                     MLENPDIGITGTKSINFLESDTQLPPWLRDKPHWEEVREILPSTIVVHKSVFSQIGVFS
                     PDYRASEDTEWQWRAKDANISIFNINEILTLRRFQGSNLSWEMKVTQKSRMLRIIKESI
                     ARKSTQAR"
     gene            14393..15085
                     /locus_tag="BDGGKGIB_RS16505"
                     /old_locus_tag="BDGGKGIB_03340"
     CDS             14393..15085
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129598.1"
                     /locus_tag="BDGGKGIB_RS16505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03340"
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_239728002.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.3e-37,
                     bitscore: 127.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLPLVTVVIPVYNSAKFLAATLDSVFAQTYRPIEVIVVDDGST
                     DNSADIVRSYPEVQYFYQSNQGVSVARNVAIAAAKAELIAFLDSDDLWKPDKLSLQIAY
                     MLENTHIGITGTKAINFLESDTQLPPWLRDHPCWEQDRVIIPSTMVVHKSVFSQVGDFS
                     PDYRASQDIEWLWRAKDAKIPMLKINEILTLRRFHGSNVSWLMAGTHKSRMLRIIKDSI
                     ARQSRQPQ"
     gene            complement(15113..15868)
                     /locus_tag="BDGGKGIB_RS16510"
                     /old_locus_tag="BDGGKGIB_03341"
     CDS             complement(15113..15868)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (65-181). E-value:
                     5.7e-14. Score: 43.7. Matches aSDomain:
                     nrpspksdomains_BDGGKGIB_RS16510_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017655071.1"
                     /locus_tag="BDGGKGIB_RS16510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03341"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_239728004.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 6.4e-13, bitscore:
                     46.5, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 7.7e-07,
                     bitscore: 26.5, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 4.3e-12, bitscore:
                     43.7, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDFLRTRQSTTKKLILLTGAAGNIGTSLQHELDDDYEFRCIDRR
                     HVPQSKDFRRVDITNFKAVLKVMAGVDAVIHLAANPHVDQPWQDVYTSGINGTYNIFEA
                     ARQSGVKKIIYASTNYVSGWREVEQESHITPEMPVRPDSLYAVGKAFGEALGQYFSDRY
                     GMTVICLRIGWFKTEPKVYAPNDRILSNWCSPRDLAQIVRRSLEHENLGFQIFYAISGN
                     TRRYWDISNAQKLLGYEPEDNAENLLIDV"
     aSDomain        complement(15326..15673)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BDGGKGIB_RS16510_NAD_binding_4.1
                     "
                     /evalue="5.70E-14"
                     /label="BDGGKGIB_RS16510_NAD_binding_4.1"
                     /locus_tag="BDGGKGIB_RS16510"
                     /protein_end="181"
                     /protein_start="65"
                     /score="43.7"
                     /tool="antismash"
                     /translation="KVMAGVDAVIHLAANPHVDQPWQDVYTSGINGTYNIFEAARQSGV
                     KKIIYASTNYVSGWREVEQESHITPEMPVRPDSLYAVGKAFGEALGQYFSDRYGMTVIC
                     LRIGWFKTEPKV"
     gene            complement(15887..16588)
                     /locus_tag="BDGGKGIB_RS16515"
                     /old_locus_tag="BDGGKGIB_03342"
     CDS             complement(15887..16588)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129596.1"
                     /locus_tag="BDGGKGIB_RS16515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03342"
                     /product="glycosyltransferase family A protein"
                     /protein_id="WP_239728005.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.5e-39,
                     bitscore: 131.6, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPLVSVIIPCYNRERYLAEAIESVLDQTYPNIELIVIDDGSSD
                     RSGEIAQSYPLIYRYQSNGGISAARNAGIALSNGEFLAFLDSDDIWVKDKLAKQMAVFD
                     TNPDIEAVFGYAQNFYSPELDESFRNRIRCPEKPIAAHISSAMLIKRSAFLRVGNFDTN
                     LKTGTDISWYISALEHQLQQITIPDVVYYRRLHESNNGITERQYANERLHLIKAKLDRQ
                     RAEKRVLNQES"
     gene            complement(16588..18009)
                     /locus_tag="BDGGKGIB_RS16520"
                     /old_locus_tag="BDGGKGIB_03343"
     CDS             complement(16588..18009)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129594.1"
                     /locus_tag="BDGGKGIB_RS16520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03343"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_239728006.1"
                     /transl_table=11
                     /translation="MNLELNKNNNQDNPALTQFKLGNAWQLRGDLENALARYQETLILQ
                     PDFLPVYQQLGNLMLKQRRIAEAMDYYEQALAIDFDATELSFYYQCLGWRKPSNSRQII
                     PDKKAENLYFPNEKLQGIARGKINLGEQRVFATHRSGWNFAIQALSSLHNPQGVLFDGF
                     LENQFLFQHHHFGRRSPRILAKMRADGVFDSLADSEEKGIVPYKTPWVGFLHNPHRMPI
                     WFNYHRSPQKLFEKQIWQDSLPQCVGLFALSDYYGDWLRKETGKPVSVLIHPTEIPEKQ
                     FDFNQFIANPQKKVVQIGWWLRKLHSIYQLPLAKGNSLGYEKVRLGFLFESSETILAQL
                     MKIEGRIYKIQVDPAYVENTTVIEHIPDDAYDDLLSMNIAFVDLYDSGVNNAIIECIAR
                     ATPLLVNPIPSVIEYLGEDYPMYFHTLEEAAAKALDTALILETHEYLKSCETRDKLSAN
                     YFLDSFCNSEVYKSI"
     gene            complement(17981..19324)
                     /locus_tag="BDGGKGIB_RS16525"
                     /old_locus_tag="BDGGKGIB_03344"
     CDS             complement(17981..19324)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015129593.1"
                     /locus_tag="BDGGKGIB_RS16525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BDGGKGIB_03344"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_239728007.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.2e-62, bitscore:
                     209.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKIISETPKNSLSPEVIALLACLKCHFHTTSVNAVRDLLRDDLN
                     WSKLIEISIAQGVMPLLYQSLKEIDDVPRSVMMQLQTLNRMNGLNNLSQTKELLRILTQ
                     LEKSGIEAIAFKGAVLAASAYGNVSLRQFNDLDILVRRRDFWQAKAVLISQGYQYNFSE
                     EAEIDGFERDLQISLSYKAPEAEMFNARFEPLLLHSNPQRSIDLHWGIPPRRTWNPNHY
                     DRLWEYCQPMTLMGQSIKSFIPEIALIIQSVNIAKEYGWSRSLKQICDVAQVIQAYPDL
                     DWHLTLRLSSELRCEKLFLLGIYITQNLFNISVPDHIVSKFIQIKSLDTQISLFNSLES
                     KTDSTLHQLFYQSRILLGIRNLYLGYTSPLKTLDRSLNRWWLDEALSMTLLYMYFLMRR
                     LLVPNERDHEFLILPQQLFFLYYFVRPIRLLWKHILKNIYESGTKQKQ"
     misc_feature    complement(19693..19706)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.88"
                     /tool="antismash"
ORIGIN
        1 ttgggctaaa ttcattaacc gccgcagttt ttcggctgct ttaggaatta tcacagacag
       61 gatgcgatcg cctgctttgg cggaggctaa taaatggctt actggacaaa ttccgcaaat
      121 tctggctgta attcctggca tttcccacag gggacgacct tcacaaaatt tctcaaatcc
      181 ccgaaattct gtcacatgaa attgggcatc gctgacttgt cctgtatcat ctaaataaat
      241 gctgattttg gcgtgtcctt ctatgcgggt tactggatct ataatgattt ttttaggcat
      301 aatgttttgg ggttttaatt ataggattta ttcacgcaga gtcgcagagg cgcagagagg
      361 aggagttatg gaacctcacc ccagccctct ccttggtaag gagagggagc cggaggggaa
      421 atattatttt tgtgcttgat tgggtgggat ttaggataca ttttactgga gtgtttaagt
      481 tagccaaatt taatcatgtc tcttccttct agttgtggtt tttctccttt taatagtggt
      541 tctaatgtgg ctttgattcg agtggctgag ggtggacatc ctggcatata aatatcaact
      601 gggactattc tatgtactgg aactactctg tctagtaagg tggggacaat tccaggttca
      661 tggggaattt gtccgtgaat atctgctgtt tctatgtaac aacgctggag tacaggctcg
      721 gcactaccta aagggttacg taaggcggta acattaccag tgactgcaca atcaccaaag
      781 gaaactagaa tgtgcgatcg ctctctgact atgtgaatca tttgcagatg atcttcgtta
      841 gcaattgcac cttcaactaa cactacatct actccttggg gatattcttt aacatcagca
      901 aagggactat aaactaagtc tacttgtgca gctaaatcta ttagccattc gtctaaatcg
      961 agaaaggaca tatgacagcc agaacagccg cctaaccaaa ctgttgctag ttttaaacga
     1021 gacataataa ttcgtaattc gtaattcgta gttggggagt taacggttat ttttttagtg
     1081 tttaagcaaa attatgagga aacgaaccgc agagacgcag aggacacaga gttatgagag
     1141 tttcagaggt tttttcgtaa gttttaatta tttaaaggtt ccattggtgt ttttctctgg
     1201 cggtgacgag gaaatctagt ttggcgcgat cgcctttggc ggggcgtagc ccatcgcgtt
     1261 tcatttctcc gacgcttgaa cctttatcaa acaatgcacc tgtaggacag gcgttaacgc
     1321 atttaccgca agaagtacaa gtttgcgagg ttccccaagg ttgatttaaa tcagtgatga
     1381 tgtgggaatt tgtccccctt cccgccatat cccaagtgtg cgctccttca atttcgtcac
     1441 aaacacgtat acaacgagtg caaagaatac aacggttatg gtcaacacca aagcgatcat
     1501 gagaaacatc gactttgcga tcagggaaat gataatctaa acgcacatga tccataccca
     1561 tctcaattgc taaatcttgc aattcacaat taccattagc gacacatacc gagcaaatgt
     1621 gattaccctc agcaaacagc atctcgataa ttgtacgccg atatctgtgt aggcgatcgc
     1681 tatctgtctt cacctccatc ccctcagtca ccttagtcac acaagcaggc tgaagcttat
     1741 tactaccagc aatttccacc aaacacaacc gacaagcccc cacatcagtc accccctgca
     1801 aatgacacaa agtcggaata taaatccccg catcctgcgc cgcttgcaga acagtctcct
     1861 cctcccgacc actaaccaac cgctcattaa tacttaaagt cttaacaacc atctcacctt
     1921 cacctccaaa aaactccgcg tacctttgcg ttaacctccg cgcccctttg cgtttaaatc
     1981 aactccaaat actcatcccg aaaatatcgc aaagtgctaa aaaccggatt aggcgcagac
     2041 tgacccaaac cacacaaact cgtatgcttc accatgtcgc ataactcctc cagcaactcc
     2101 aaatcagcaa gacaagcctc accctcacta atcctcgtca acaagttaaa taactgcacc
     2161 gttcccaccc gacaaggaat acacttccca caagactcat ccatgcaaaa ttccataaaa
     2221 tagcgggcga catccaccat attcgtactt tcatccatga caatcatccc ccccgaaccc
     2281 ataatcgatc caagttcagt cagagattca taatccaccg gactatcaaa agccgatgcg
     2341 ggaatacatc ccccagaagg tccaccagtt tgcacagctt tcaccacacc cccattcggt
     2401 acaccaccgc ccatgacttc cacaatctgc tgtaaagaag ttcccattgg cacttcaatc
     2461 aaaccagtgt tagtgatttt acctgctaag gcgaaaacct ttgtaccctt gcttttttca
     2521 gtcccaatac tggcgaacca ttccgcacct ttacgaataa ttggtgcaac attggcgtag
     2581 gtttcaacgt tattaattaa cgtcggatag ccccacaaac cggactcagc cgggtaggga
     2641 ggacggggat gaggagtacc acgtttcccc tcaatcgaag ccattaaagc cgtttcttca
     2701 ccacagacat aagcaccagc accgatgcga atatcaattt taaaatcaaa gcgagagtca
     2761 aaaatttgac ttcccaaaat gccaaagctt tgcgcttgac gaatggcaat ttgcagacga
     2821 ctaatagcaa caggatattc ggctctaatg taaatatagc cttgatttgc acctacagca
     2881 taagcggcga tcgccattcc ctctaaaacc cgatggggat cactttcgag aacgctgcga
     2941 tccataaatg cacctggatc tccttcatcg gcgttacaaa ttacaaactt gcgttctccc
     3001 tttgctttcg ccacagtcgc ccatttcaaa cctgtcggat aaccagcacc accacgtccc
     3061 cgtaaaccac tgcgggtaat cgcatctacc acctcggtag gagtcatttc tcgcaagaca
     3121 tgataaaggg cttgataacc ttccgcagca atataagatt gaatgcgttc tggatcaatt
     3181 ttgccactgt tttctaacac aatggacatt tgagatgtaa aaaatggatg agttaaatca
     3241 ctctgtgaaa ctgctgtttc tcccccattc agagcagtaa taattgaggg tgcatcatct
     3301 ggtgtaactt tttcgtagag cgtatttaca ctttctgatt cagtgtttct ctcaacctga
     3361 actaatggac cttgacaaca caaacgcata cagccaacgc cataaacttc tactttttcc
     3421 gccaaatttt ctgctgtcac agcctcttct agacgctgtt taactgcttg tgaattagta
     3481 gctaaacaag cagctgcaat acaacagcga atttgcacag gtttctgtga atcagattct
     3541 ttgcgggcaa tttcctttaa ttcagctaga tccattttgc agccatcctt tgatgcattc
     3601 gccaactgat tccggagttt ggtcgcctaa aacggtatca tcaaatacta caacaggcgc
     3661 aattccacaa ggaccaagac acctggctgt gagcagtgaa atttgaccat ctgttgatgt
     3721 ttcaccaggg cggatatgta tagaattttc cagactgttg aggatttctt cagcgccttt
     3781 gacataacaa gctgtacctg tacacaccat gcaactatgc acgccaatag gtgcaagtga
     3841 aaaaaaatgg tagaacgtcg caacgccata aactgtacta ggtggtagtt ttaattggtg
     3901 cgcgatataa actaatacat ccttttctaa atagccaaaa agttcctggg ctttgtgcaa
     3961 tatctcaatc aatgcatcct gttgatactg atagcgtttg attgttgctg acagaatttt
     4021 taaacgctta tccccttgag tatctgttgc tgaggaagct tttgcttggt tgttattttt
     4081 aacagcagat gctaaatcca tcgctctcgc ctcttggttg cgatgttcca agtctaacaa
     4141 tccattaaga tgatagaaga acaatttgag aaacttgtga tgaaagttaa acttaatttt
     4201 tttcatgggt tttagttcag taatatcaag ataaaacggc aacagatata atagacatct
     4261 ccgggaaaga atgtagagac gttccatgga acgtctctac aaggattcga ggaaacgcat
     4321 atttaatttt cggatatgtc taatgattcc ctgtgaattt atgattttag ttgtcttcac
     4381 catttgggta gattttttgg tttgcaattg acagaacaaa gttttagatt gaggtgtcat
     4441 gactatgcaa aaacgactgg gtattcttac cagtggtggc gattgtccgg gattaaatgc
     4501 tgtgattagg gcagttgtga gtcatgctac tctcacctat aactggcagg tagtgggtat
     4561 tccttatgca acgagaggac ttttagaaag aaaggctatt cctctgagca tacatggttt
     4621 agacctccga ggtattgacc ctttgctgaa tatgggaggc acgattcttg gtagtattaa
     4681 taaaggggat actctggctc atgctgagga aattattgct ggctatcatg ctttagaatt
     4741 agatgcgttg attggtattg gtggcgatgg cagtttagca attcttaccc aactccaaag
     4801 tttaggaaat tggcagtttg tggcgattcc gaaaacaatt gataatgatg tcggtcagac
     4861 agaaagagta gttggctttg atactgcggt aaataccatt gttgacgctc tcaatcgttt
     4921 gacgtttaca gctgctagtc atgaccgggt aatgattgtg gaagtgatgg gacgcaaagc
     4981 cggacattta gcactacact ctggtattgc tgggggtgca gatgtgattt tgattcccga
     5041 aattccctat tcaattcaag gtgtgtgtga acatttggca gaattgcgcg agcgctgggg
     5101 acgtagattt gctattatag ttgtagcaga aggcgctcaa atcgccgtag attcatccac
     5161 ctattcatcc tgtgaacggc cgtcttgtgg tatgggtcag tatatcgccg atgaaattgg
     5221 tgattgcact caggatcaaa ttgatattcg ggtttccgtt ttaggacata ttcaacgtgg
     5281 tggtataccc tcagctttag accgtttaat ggccacagcc tttggtaaag ctgcggtaga
     5341 tttgttagct gataatcaat ctgcacagat ggtagcttgg caaaatggac aagttgtagc
     5401 agttcctcta gaagcagttt tagcttccag tccatgtctt gtagatcctg ataatttctt
     5461 agtgcaaacg gcgcgatcgc tcaatattta catgggaaat atgactttgg ggacaacagc
     5521 atgagcgcca ccaagagtga acttagaaca tactctgcgt gattaaaata gaagcaaaga
     5581 caagtttgac tttctcattc ccacattccc ctaaactaaa agcagcaaac ttgtttaaac
     5641 tggttgagga aaatagattt tgacagaaac gaataattta aactttacca cccaaaatgc
     5701 cacccgtagc gaattgcggg atttagtgcg aaatcagtta caaattctac tggaagcggg
     5761 gaacttgcag gaagcaaaat ttattctcca acctgtgcaa cctgcggata ttgctgaggc
     5821 cattgaagga ttaccagaag caatgcacgc tttggttttt cgcttgcttc ctaagactga
     5881 agctatcgag gtttatgaat atctcgacta cactgtgcaa gaacatttaa ttgaagaact
     5941 cagaagtcag gatgtccgtg atattgtaga taaaatgtcc ccggatgacc gcgctaggtt
     6001 atttgacgaa ttaccagcca aagttgtcaa tcgcttacta gaacaactga gtcccacaga
     6061 acgccaagct acagcccaac ttttgggtta tgaggcggat actgctgggc ggatcatgac
     6121 accggagtta atttatctta aagaaaattt cacggtatct caagccatag agaggattcg
     6181 cagcctcgct aatgttagtg aaataattta ctacctttac gttaccgatg gtgttaggcg
     6241 tttgacgggg attgtatctt tacgcgagtt ggtggtatct cagcctgaac aaaccattgg
     6301 cgaaattatg acccgtgaag tggtgtttgt ccacacggat acagatcaag aagaagttgc
     6361 taaattaatt caaagatatg attttttagc tgttcctgtg gtggataaag aacagcgtct
     6421 agtgggtatt gtcaccgttg atgatgtgat tgatattctg caacaggaaa ccaccgagga
     6481 tatctacgct ttgggcggtg gtgtgcagtc cgatggtgac aactattttc aaatgagttt
     6541 actgcaagtt gcccggaagc gggtggtgtg gttgtttgtt ttactgataa ctaacacagt
     6601 cactggtaca attattaagt cccaagaaga tattttaaaa caagcggtga ttctgacggc
     6661 gtttattcct ttgctcacag gtactggtgg aaatgtcggc gctcagtctt ctacagtggt
     6721 aattcgcggg atgagtaccg atgaaatcag atccctgaag atatggcaga taattggcag
     6781 agaagcgatc gccggggcgt ttttgggttt aatgttaggt agcatcgcca cagtctgggc
     6841 ttactttctg caaggacgcg ccgaggtagc tttcactgta ggtatcagtc tggtagctat
     6901 ttctattatt gcttctgttt caggttcagc actgccattt ttattccgcg ctttccgctt
     6961 agatccggcc ttgatgtcag caccatttat tactacagcc gttgatgtcc tgggtgtttt
     7021 gatttacttt agcttggcgc gagtaatttt agggttataa gttgtgagcg ccccaggagg
     7081 ggaagtcaaa agtcaaaagt caaaagtcaa aagtattaaa ttacctcgca acgaatgaaa
     7141 caaatacatt tttttctttg gctaaaatcc ctgctatata aggattataa aatgtgttag
     7201 ttatgagtta tcatgcgtcg ttaatgtaat gaaaactctg caattctgac tctaaaattt
     7261 ttacaattct gaagccgtct ctggtgcaac aatttcccca ctacctaatt ctaggatcat
     7321 atcttgatcc gtaattaatt cattgagttc cttcacttgt aaattcattt tctcacaaga
     7381 gtttctcagt tcgctggcaa aagtattaat atcatcgcca tagccacatt gataagcagc
     7441 agtttctatt ccctgcttgg catttgctct agcacaatct actaattctg tgccaagcaa
     7501 tggttttgca gatgtcataa gtcgtagttg ttatttgtta cttgtttctc gttagctaga
     7561 ctagcattta tttactatta atccatccat ccgatggcag agaaatatca attagatcag
     7621 taggacggcg taaatcatta aaggtttgta gtgaggactt tagtcctcaa atagatgctc
     7681 aagccctgac aacgaactga attacataag ttgacattgc ttaacatagt ttaatttatt
     7741 cccgcctact tacttattta tttggtgaaa aagaatgtag agacgttcta cgtcaggtct
     7801 ctacgagggt gatatcagac gcatatttaa attctgtcga tgtctattgg taattgtgaa
     7861 aatgtcagat cccgatatct tgaagatatc gggattttca tctgttgcta aatgattatt
     7921 tatctctttt ggcattagcc gttgactatt gatccaccat tgggatgtaa tacttgtcca
     7981 gtcatataag acgcatcatc ggaagctaaa aagacataac tgggtgcaac ttcttcaggt
     8041 tgtccggctc ttcccattgg tacttgtttc ccgaaagttg caacttgatc tgcgggaaag
     8101 gttgaaggaa ttaatggtgt ccaaatcggt ccaggtgcta cagcattaac tcgaatgcct
     8161 tgggagacta aattttgtga taaggaacga gtaaaggcga ctattgcacc ttttgtagat
     8221 gagtaatcga ggagtagggg attgccttta taagctgtaa ctgatgtact attgataatg
     8281 gcactacctg cttttaaatg tttcattgct gcttttgtca ggtaaaacat cgagaaaata
     8341 ttagtgcgaa aagtgcgctc tagttgctct ttactaattt cctcaatgtt ttctttcggg
     8401 tgttgttcag ccgcgttatt aatcagaata tcgagtttac caaattcatc aacagtttgt
     8461 tctacagctt gctgacaaaa ggtttcatca gtaatatcgc cggcgatcgc tactacacgt
     8521 cgcccttgtt tttctaccaa atgtttggtt tctttcgcat cgtcatgttc gtttaagtaa
     8581 acgatcgcca catctgcacc ttctttcgca aaggcgatcg ccacagcccg accaatacca
     8641 ctatctcccc ctgtaattaa tgctacttta ttatctaact taccactacc ttgataatgg
     8701 ggatcatcag ctttgggttt gggctgcatt tctgattctt taccgggtgg tttttgttcc
     8761 tgtggtggtt gtaaattttc ttctggcatc agataatttt cctgtgaatt gatcaagaaa
     8821 aaatgattaa caaaattcta aaagtaaacc ctggatcgat aattcaatcc aaggttttat
     8881 ttatgcttta actcccaact tacaatttgt aagttcaggt atttttaccc cggatgtaag
     8941 ccaaacgcac taattgaagg caattgcacg cgaccgacat ttttatcctc acacctgaca
     9001 cacgctctta atctgaccac tgaaaacaag tacacaactc tcttggaata tcaggattgc
     9061 tcctgttcat ctgcttttaa gttaactacg aaattgggta aatttatcat tctgaagatg
     9121 gaaagacaaa tttacttttc tcaaccttaa gacgtaaaat aaggtattat taatcaatga
     9181 tttaaatgtt aatttcactg aattatggcg aatcaaacat tgggaataga accaaaacta
     9241 tataactact tactctctgt atctttacgg gaaccagaaa tcctgtctca actgcggaaa
     9301 gaaacagcgc agcatcccat gagtgaaatg cagattgcac cggaacaggg acaatttatg
     9361 gctttgctgg tgcaattaat aggagcaaag aaaactttag aagtgggggt atttacgggt
     9421 tatagttccc tagctgtggc tttagcatta cctccagaag gtcgggtagt agcctgtgat
     9481 gtgagtgagg aatttactgc gatcgctcgt cgttattggc aagccgccgg ggttgcggat
     9541 aaaatagact tacacattgc cccagcaatg gagacattag atcagttact cgccgcaggt
     9601 gaagcggaaa cctttgattt cgccttcatc gatgctgaca agagcaatta tgatggttat
     9661 tatgagcgat cgctaaaatt agtccgtcct ggtggattaa ttgtgattga taatgttctt
     9721 tggtcaggaa aagttgcaga tagcgaagtc caagacaatc gcaccacaaa gattcgcgcc
     9781 ctgaatgaga aactgcatca agacgagcga attaacctga gtttagttcc tatcgccgat
     9841 ggtttaaccc tagcgcacaa gaaataattc ctgtagaggt aattcatcaa ttgcctctat
     9901 agaaaaagtt ttgaatttta tagtattaat aattaggagt catattatac cataaagcat
     9961 ggtattgtgt aaaattaata gtcaagttgt cagaatttat atggagaata gccaagtgtt
    10021 tagagtcaat agtcctcaag ttgtctgtga aactattgat ggagaagtgg tagttgttga
    10081 tcttgagcgg ggttactatt acagtctgct caaaactggc gcagatttgt ggagttgtat
    10141 cgagggtcat cttcagcgcg atgacataat ccaagaaatt ggaaaaaagt atgatgggac
    10201 tatcgaagaa attactgagg cgattgatga atttcttgac aaattgcaac atgagggatt
    10261 aattgttgct gatgtcacta ttacaccagg ggctatgaat gagcaagaat cagttaccag
    10321 taccgaaaag cccaaatttg agaaaccgat gctagagaag tttacagata tggaagattt
    10381 gctgctgctt gatccgattc atgaggtgga tgtagaagct ggatggccaa aggtgaagac
    10441 ggtttcatag tgaatacaat attttgattt tactatgagt ttaaactgga gcgatggcgt
    10501 agccgcccgc caagggcttc gcctggctta ctttgatagt tatcgattaa aattgtccca
    10561 caaacaatta ctcaaagcca cactgttaaa agagcaggca atgttaacgg cttggcaaga
    10621 ttggcgagat tcagttgata tagaaacttt agatcatagt tcctattcat tgttgccaca
    10681 actttaccaa aacttattag ctcataaagt tgataacgct gatatggcaa ggctaaaggg
    10741 gatctatcgc cgccattggt atgctaatca attgaaactc aaatcgctaa cagcaatatt
    10801 gtctagttta aaggatattg gcattgaggc gattgtgctg ggggatgcgg cttggggtgg
    10861 gataggtaaa aatcaaatcg agaattaccg cccaatttct agcttccatc tcttgcttga
    10921 tggcaattat ttagagacag caatcgagca tttgcgctcg ctaaattggc atagtcttga
    10981 tggtagtacc caacaattta gggaattacg taataattgt gattcactga atttacggct
    11041 ttatttgcaa gaacatctgt tttgggcaat tccccaagac tatacagatg ggcaggtgtg
    11101 gcattatgca actgcggatt ggagccatga agctggttgg cggctgagtg caacggatca
    11161 gttcctggat ggatgcgcgc gaatgttttt tagacagcag cccaaatcat cgaatccaca
    11221 aatacacagg attgcagatg ctttggtgtt aattgcgaat ctggaaaaca acgattggat
    11281 caggttgatc acacaagcac aacgatatca aatgatcttg cctgtgcgga atatgttgca
    11341 gcttttgcag cagttatttt cagtagaatt accaacttgg gtattaccgg ctctctggca
    11401 aatgccgatc gccaatacgg agtggttaaa gtatcgagtt ttagatggcg atcgccgttc
    11461 tctgatgcgt tcaaccattg tgcaatcgct acaactgttg actttttcaa agtaattgtt
    11521 tcttaactag attccagtga ttgtcatgta tcctaaccct gatcggagta ttgctcagag
    11581 cgatcgcctc gcttatttcc aattagtata tacaggcttt gagagagccg ctcaaattgc
    11641 cggcgaggtg cagtattttt atgccatcgg taagtataat ctctgtctaa gatttgcggg
    11701 agaggggctg attccccaga ttacgcctgc attgtctcat ctctctatag ccccagttcc
    11761 ccaacccgat ctcacgattt gcctatggga taatacctca actaaaacac aattgccatt
    11821 attaattgat agtttattaa ccctgattcg actacattgg acagattatc tcggtccacg
    11881 caaagagatc aaagcctatg atggcgatcg cattcgcagc aattttcata ttggtcccaa
    11941 cattctcagc gtgctagatc gagagcaaaa tttagcttgt tattggattg acaatgctga
    12001 agatattcct tattgggaaa aaggttcacc tttgcaaaca attttaaact ggtggacaag
    12061 cgatcatcgc caacatcaat atgttcacgc aggtgcgatc ggtaatcctg atggtggagt
    12121 tttgttagcg ggaaaaggtg gatctggcaa atcttccact gcgcttacct gtatcaatag
    12181 ttcgctgctt tatgccagtg atgattattg tttagtcacc agtgatcctc aaccctatgt
    12241 ttatagtctc tacaacaccg ccaaattaaa aggacaagcg gatctcgaac gatttcccca
    12301 tttagcggat ctcattgata attgcgatcg ctcagagaat gaaaaagcaa tgctattttt
    12361 gcatcaacac catcctgaaa aagtcgtaca aggatttccc atcaaagcgg tgctagtgcc
    12421 tcaaatcaca gggaaactag acacccatct ccgtcccatc agtgcaggag cagccttacg
    12481 cgccttagcc cctagtacca tctttcaatt agctggtagt ggacaaacag cattaaaaat
    12541 catgtcaagt ttagtcaaac aggttccttg ctatgttttg gaacttggta cagatatggt
    12601 acaaattccc gatgtaattc aacgtctgct atcgcaaata taaatctggg caacttaaaa
    12661 caggagtcta taacatggga tatctccggc gaaaaatgat tgagggatta actcgatttg
    12721 tgccgacaat tcttcctccc caaaggcaat actataacga aaccaataat gatcgatgga
    12781 tttgtgaata tgtctttccc aataaacggg atggttattt cttagaagtt ggagcagcga
    12841 atggcaaaca agcaagtagt tgttatgtcc ttgagaaaga gtttggatgg aaaggaattt
    12901 gtgttgaacc gagtgattac ttttttgagc aattggttcg caatcgtccc aatagtattt
    12961 gtgagcaagt ctgcttatcc aatcaagtag gaactgtaac ttatatcgaa ggcagcgatg
    13021 agacggttag cccttattta agcggcatca aatcgaactt agaaacagtc aaatatcagg
    13081 ggaaagaggt tgtcgccaaa ggcaaagaag ttaaaaaaga ggcagtaacc ttagaggtgc
    13141 tgctcaaaaa atatcatgct cctcaagtga ttgattatgc tgcttttgat attgaaggca
    13201 gtgagttgga tgttttagaa gtttttccct ttgagtctta tgtctttcta gctctgagtt
    13261 tggaatgtga tagttctatc cgtttaccca tttctcagtt attagaatcc aatggctatc
    13321 gacgcgctaa aaatccattt aatcgggata aaccttggga aatgtattgg ttacatcaga
    13381 gtgtttacaa acgtctgtga gcatattttt ggtataatat cgaggttttt atcctaacag
    13441 tttttgggca ttaatgaata acttaccttt agtaactgtg attatccctg tctataatta
    13501 cgctaattat atagccgcaa cacttgacag tgtatttgct caaacctatc gcccaattga
    13561 agtcattgtt gtggatgatg gttcaacaga taacagtgcg gaaattgtgc gtgcttatcc
    13621 agaagtacag tatttttatc aatcaaatca aggtgtgtca gttgctcgca atgtggcgat
    13681 cgctgctgca aagggtgaat ttcttgcatt tttggatgca gatgatctct ggaaacctga
    13741 taaactcagt cttcaaattg cctatatgct ggaaaatcct gatattggga tcacaggtac
    13801 aaaatcgata aattttttag aatcagatac tcaacttccc ccttggctaa gagataagcc
    13861 ccattgggaa gaggtgagag agatccttcc cagcacaatc gtggttcaca aatctgtttt
    13921 tagtcaaatc ggggtattct ctcctgatta tcgtgccagc gaggatacag aatggcaatg
    13981 gcgagccaaa gatgcaaata tatccatctt taatatcaat gaaatcctga cattaagacg
    14041 atttcagggt tctaatctat cgtgggagat gaaagtaact cagaaatctc ggatgttgag
    14101 aattatcaag gaatccatcg ctcgtaaatc gacccaagct cgatgagcta atctatttta
    14161 ttcattcata gaattaaaca cctttcaaca gattttcggc attatcttca ggttcgtatc
    14221 ctaatagttt ttgggtatta tagctgtatc cacttcaatg aagtacatca tagccccctc
    14281 ctcgcacccc ccgaaatccc cccgcaacgg ggggaagaaa aggataaacg tttgatatgg
    14341 gagggggttg ggggtggggt tcttgtatct cacttaactg ataaccgcta taatgaataa
    14401 tttaccttta gtgaccgttg ttatccctgt ttataactct gctaagtttt tggctgcaac
    14461 acttgacagt gtatttgctc aaacctatcg cccaattgaa gttattgttg tggatgatgg
    14521 ttcaacagat aacagtgctg acattgtacg tagttatcca gaagtacagt atttttatca
    14581 atcaaatcaa ggtgtgtccg ttgctcgcaa tgtggcgatc gcggcggcta aagctgaatt
    14641 gatcgcattt ttggattcag atgatctttg gaaacctgat aaactcagtc ttcaaattgc
    14701 ctatatgttg gaaaatactc atattgggat cacaggtaca aaggcgataa attttttaga
    14761 atcagatact caacttcccc cttggctgag agatcatcca tgttgggaac aggatagagt
    14821 gattattccc agcacaatgg tggttcacaa atctgttttt agtcaagttg gagatttttc
    14881 tcctgattat cgtgccagcc aggatataga atggctgtgg cgagccaaag atgcaaagat
    14941 acccatgctt aagatcaatg aaatcctgac cttaagacga tttcacggct ctaatgtatc
    15001 atggctgatg gcaggaactc acaaatctcg gatgttgaga attatcaagg actccatcgc
    15061 tcgtcaatcg cggcaacctc aatgagctaa tctatgttat ccattcatag aattaaacat
    15121 ctatgagcag attttcggca ttatcttcag gttcgtatcc taacagtttt tgagcattgc
    15181 tgatatccca atagcggcga gtgttacctg aaatagcata aaaaatttga aagccaaggt
    15241 tttcatgctc tagcgatcgc ctaactattt gtgctaaatc tctagggcta caccaatttg
    15301 ataatatccg atcattggga gcataaactt tcggttcggt tttaaaccag ccaattcgca
    15361 aacagatcac agtcatccca tagcgatcgc taaaatattg ccctaaagcc tcaccaaatg
    15421 ctttccccac cgcatacaga gaatcaggac gcacaggcat ttcaggcgta atatgggatt
    15481 cttgttccac ttcccgccat cctgaaacat aattggtgct ggcatagata atttttttga
    15541 ctcccgattg acgggcggct tcaaatatgt tgtaagtgcc attgataccg ctagtataaa
    15601 catcttgcca aggttggtca acatgaggat tggctgctag atgaattacc gcgtccacac
    15661 cagccataac tttaagaaca gctttaaagt tggtgatatc cacgcgacgg aaatctttgg
    15721 attgcggaac atggcggcga tcaatacagc gaaattcata atcatcatcc agttcatgct
    15781 gtagagatgt gccaatgttt ccagccgcac cggttaataa aatcaatttc tttgttgtcg
    15841 attgacgggt tctcagaaag tcaaacatac tagtgctgtc gcctcctcaa gattcttggt
    15901 ttaaaactct cttttctgca cgttgtcgat ctagcttggc tttgatcagg tgcagtcgtt
    15961 catttgcgta ttgacgttct gtaattccat tattgctttc atgtagtcgg cggtaataga
    16021 ccacatctgg aattgtaatt tgttgaagtt gatgttccag ggctgagata taccaactaa
    16081 tatcagtacc tgttttgaga ttggtgtcaa agtttcctac tctcaagaaa gccgaacgct
    16141 tgatcaacat agcactagaa atatgcgccg caattggttt ttctggacag cgaatcctgt
    16201 ttctaaagct ttcatctaat tcggggctat aaaaattttg agcatagcca aagactgctt
    16261 ctatatctgg gttagtatca aagaccgcca tttgttttgc tagtttgtcc ttaacccaaa
    16321 tatcatcaga atcgagaaag gcgagaaatt caccattgga cagagcaatt ccagcatttc
    16381 tagcagcact gattccgcca ttgctttgat aacgatatat cagggggtag ctttgggcaa
    16441 tttcgccact gcgatcgctc gatccatcat cgattacaat caactcaatg ttaggatagg
    16501 tttggtctaa aacactttcg atagcttcag ctaaatagcg ctctcgatta tagcagggaa
    16561 taatcacgct aactaaaggt aaattcatca gattgattta tatacttcac tattacaaaa
    16621 actatctaga aaataatttg ctgatagttt atcacgagtt tcgcacgatt tcagatattc
    16681 atgagtttct aaaatgagtg cagtatccaa tgcttttgct gcggcttctt ctagagtatg
    16741 gaaatacatc ggatagtctt cgcctagata ttctattaca ctaggaatag gattaactag
    16801 cagtggtgta gcacgggcaa tgcattcgat gattgcatta tttacaccag agtcatacaa
    16861 atccacaaag gcgatattca tcgacagcag atcatcatag gcatcgtcgg gaatatgttc
    16921 aataacagtt gtattctcaa cataagcagg atcaacttga attttataaa tcctcccttc
    16981 gattttcatc agttgagcta atattgtctc tgatgattca aacaaaaaac ctaatctgac
    17041 tttttcgtaa ccaagagagt tacctttagc tagaggtaat tgataaatcg agtgtaactt
    17101 ccgcaaccac cagccaatct gcaccacttt tttctgagga ttggcaataa attgattaaa
    17161 atcaaattgt ttttcaggaa tctccgtggg atggattaat accgaaactg gtttacctgt
    17221 ttctttcctc agccaatcgc cataatagtc agatagtgca aacaatccca cgcactgagg
    17281 caaactatct tgccaaattt gcttctcaaa tagtttttgg ggcgatctgt gataattgaa
    17341 ccagatgggc atcctgtggg ggttgtgcag aaatcccacc caaggagttt tataaggtac
    17401 aatacccttt tcttctgagt ccgctaaact atcgaaaact ccatcagccc gcattttggc
    17461 taatatccgg ggcgatctcc taccaaagtg atgatgttga aaaagaaatt gattttctag
    17521 gaagccatca aacaaaacac cttggggatt gtgtaaagaa cttagtgctt gaattgcaaa
    17581 attccaacca ctacgatgag tagcaaaaac tctttgttct ccgagattaa tttttcctct
    17641 ggctatacct tgtagttttt cattaggaaa ataaagattt tctgcttttt tatctggaat
    17701 aatttgtctg gaattgctgg gttttcgcca gcccaaacat tgataataaa aagaaagctc
    17761 agtggcatca aagtcaatag ctaaagcttg ttcatagtaa tccatcgctt ctgctatccg
    17821 tcgttgcttg agcatcaaat tgcccaattg ctgatagaca ggcaagaagt ctggttgcag
    17881 tattaaggtt tcctgatagc gcgccaaggc attttccaag tcaccgcgca gctgccaagc
    17941 atttcctaat ttaaattggg ttaacgctgg gttgtcttgg ttattgtttt tgtttagttc
    18001 cagattcata gatgtttttg agtatgtgtt tccataataa gcggatggga cgaacaaagt
    18061 aataaagaaa aaataattgc tgaggaagta ttaaaaattc atgatcgcgt tcattcggta
    18121 ccaataatct tctcatcaga aaatacatat ataataaagt cattgaaagt gcttcatcga
    18181 gccaccaacg atttaatgac ctatctagtg tttttaatgg tgaggtatat cctaaataca
    18241 gattgcggat acccaatagg attctacttt gatagaaaag ttggtgtaaa gtgctatctg
    18301 tcttactctc tagggaattg aacagtgaaa tttgtgtgtc cagggattta atctgaataa
    18361 attttgatac aatatgatct ggtacagaaa tattgaagag attttgggtt atatagattc
    18421 ccagtaaaaa tagtttctca caccgcaact ctgaagatag tcgcaaagtt aagtgccaat
    18481 ctaaatcagg atatgcttgt atcacttggg caacatcaca aatctgttta agcgatcgcg
    18541 accatccata ttccttggca atattaacac tttgaataat taacgctatt tctggaatga
    18601 aacttttgat agattgaccc atcagtgtca tgggctgaca atattcccaa aggcgatcgt
    18661 aatggttagg gttccaagtc cgtctaggtg ggatacccca atgtaagtca atactacgtt
    18721 gtgggttact atgcagcaat aatggctcaa atctggcatt aaacatctct gcttccgggg
    18781 ctttgtaaga cagagagatt tgcaaatctc tctcgaatcc atcaatttca gcctcttctg
    18841 agaaattata ctgatagcct tgactaatta aaactgcctt tgcttgccaa aagtcccgtc
    18901 gccgtaccaa aatatcaaga tcattaaact ggcgtaaaga cacattacca taagctgatg
    18961 ctgcaagtac tgctccctta aaagcgatcg cctcaattcc tgacttttct aattgcgtca
    19021 aaatccttaa cagttcttta gtttgagata agttattcaa tccattcatg cgattgagtg
    19081 tttgcagttg catcattacc gagcgcggga catcatcaat ttccttcaga ctttgataca
    19141 gcagaggcat tacaccctga gcgatgctaa tttctatcaa tttagaccaa ttaagatcat
    19201 ctcttagtaa gtccctaact gcgttaacac ttgtcgtgtg aaaatggcac ttgagacaag
    19261 caagtaaagc gattacttcc ggagataaac tatttttagg agtttcagat attatcttat
    19321 ccatgatttc atcacacaaa aaaaagcctg tttcagaata gcgccaattg gtatatacag
    19381 cactttgcaa gtaaataaag tacacatttt tatatgatga atcttgtggg ggaggacaag
    19441 gactgcccgc cctgcgtacc tactcaaatg aaatttacta tattatcgat aatttttagc
    19501 ttgggttgta aataaatcag catatttacc attgagagac atgagttgat cgtgagttcc
    19561 actttcgaca atctcgccct catgcaacac ataaattcga tctgctgttt tcacagtagc
    19621 cagtcgatgg gtaataagca aaactgcgcg atcgcccatg atttctcgaa acttctggaa
    19681 taccgccgcc tctgcataag catccatgct actggtcggt tcatctaata ttactaactg
    19741 agcatctcgc aaaaaagcac gagccagagc aattttctgc cactgaccac cactcaattg
    19801 ttctccgccc ttaaaccatt tacctaacaa agtttcatat tcttgcggta agttcttaat
    19861 aacagaatca gcacctgaat attgagatgc ttccataact tttggagaat caggtgataa
    19921 atcaatatta ccaacccaga tattttcctt cgctgtgagt tgatagcagg tatagtcttg
    19981 aaaaattaca ctaatctgac gctgtaaatc attgatacca aagtcttgaa tattcactcc
    20041 atcaatagta atactaccgc tagttacatc ataaagacga caaaacaatt tcactagggt
    20101 agttttgcca gaaccatttt caccaaccag tgccaccact tcttgagggg caattttcag
    20161 attgacttgt ttaattgcct tcctagacga attttgatgt tgaaaggtca cattctcaaa
    20221 aacaataccc ttttgcattt tagatggaac tggcttcggc tgcatagttt catacatccc
    20281 atttgggaga gccaagaaat caaatatatc cgacagaaat aaattatttt catgcagtcc
    20341 acctagacta gcaatcaagt ctttgagtcc attttgtccc ctctgaaatg cttgactata
    20401 tagaactaaa tcacccaatt gaaacttacc gtaaattgtt tgatgaataa
//
