LOCUS       NZ_CP084681            22682 bp    DNA     linear   CON 30-APR-2024
DEFINITION  Streptomyces inhibens strain NRRL30439 chromosome, complete genome.
ACCESSION   NZ_CP084681
VERSION     NZ_CP084681.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces inhibens
  ORGANISM  Streptomyces inhibens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Gillane,R., Talbo,G.H., Plan,M., Palfreyman,R.,
            Haber-Stuk,A.K., Power,J., Nielsen,L.K. and Marcellin,E.
  TITLE     Multi-omic characterisation of Streptomyces hygroscopicus NRRL
            30439: detailed assessment of its secondary metabolic potential
  JOURNAL   Mol Omics 18 (3), 226-236 (2022)
   PUBMED   34989730
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Palfreyman,R. and Marcellin,E.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2021) EMS, Australian Institute for Bioengineering
            and Nanotechnology, Cnr College Rd & Cooper Rd, Brisbane, Queensland
            4103, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. APRIL-2018
            Assembly Name                     :: AIBN_shyg
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 239.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022221585.1-RS_2024_04_30
            Annotation Date                   :: 04/30/2024 04:58:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,775
            CDSs (total)                      :: 8,682
            Genes (coding)                    :: 8,305
            CDSs (with protein)               :: 8,305
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 377
            CDSs (without protein)            :: 377
            Pseudo Genes (ambiguous residues) :: 0 of 377
            Pseudo Genes (frameshifted)       :: 158 of 377
            Pseudo Genes (incomplete)         :: 310 of 377
            Pseudo Genes (internal stop)      :: 38 of 377
            Pseudo Genes (multiple problems)  :: 116 of 377
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:32:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4897506
            Orig. end                         :: 4920188
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084681.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Australian Institute for
            Bioengineering and Nanotechnology, Building 75,Cnr College Rd &
            Cooper Rd, Brisbane City QLD 4072.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22682
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="17"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22682
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22682
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12682](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12682)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    626..646
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.82"
                     /tool="antismash"
     gene            complement(655..1407)
                     /locus_tag="KI385_RS22395"
                     /old_locus_tag="KI385_22455"
     CDS             complement(655..1407)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013500.4"
                     /locus_tag="KI385_RS22395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22455"
                     /product="barstar family protein"
                     /protein_id="WP_238573953.1"
                     /transl_table=11
                     /translation="MLAEMAPRLPLYRLIEDELRREIFTAIDMQGFFVPASREESSEIC
                     LVGVSPAPGITPSLFDDVELQVLSRCSEVIGSYYVGRIEVTDIRRTGASDDARACDLTA
                     SFFGYASPFPFAGDFWRKWAAERRPALGEWKKYPIEAHDSWLHVVQTAWFGAGRSAIRY
                     SEKSQYEIDGGDVASMASFYCALGEAVNGPGGYFGSNLDALADCLSRSEPFLLAWRDSG
                     AARESLGSAEFSSIIDTLREFKITVVFR"
     gene            complement(1516..6255)
                     /locus_tag="KI385_RS43950"
                     /old_locus_tag="KI385_22460"
     CDS             complement(1516..6255)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536580.1"
                     /locus_tag="KI385_RS43950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22460"
                     /product="putative T7SS-secreted protein"
                     /protein_id="WP_281066886.1"
                     /transl_table=11
                     /translation="MNWLGDGLNAIGDGASKFTDAVERGAGELVEHGSDLAGDALETVG
                     LDDAGHAVRTAGADLAGALGAHVDERQLGETEDPKELIHGDVEKINETASHLKDFSAAF
                     DRVANGMRKLGSGHHWSGKAADAFREAFDMHPKQWMHAADACDDASKALKSYAETVTWA
                     QGKAVDAIEKYRKAQQAAERAQSEYESQYDSYRERHSAYEYLASRGTDAGAEPQAPSDP
                     GDVGKEGREAAEDILKDARSQRNEAADRARNAIKGALAHAPDKPAFTELAGAALKDGGE
                     AFVLAHVHMVGGALKAGADTLKLARTINPLDPYNITHPWKYAGNTATLLMGLAQAGLHP
                     IDTAKGMLGSGWGSDPFDSFSAAIVNAVGGKGAGALAKGVAKAGAKNAAKAAARTAAKE
                     GGKRTVRDRLRTAWCKTFGSDPIDMATGRMHLPQTDITLPGSLPLAFTRTFESSYRTGR
                     WFGPTWMSTVDQRLEIDSEGVILIGEEGNFLLYPHPAVGVPTLPIEGDGAPLELTPDGD
                     YLLTDPVTGTRRYFTTYAENLAVLDEISDRRGNHHTFDYTADGTPTAITHSAGYRLLLT
                     TDEGRITALHLAGAAADGSDQLLVTYGYDELGNLTTVTNSSGLPLRFTYDDAGRITSWT
                     DTNNSSYHYVYDDQDRCTSQGGIEGHLRANFTWGEPDPTTGLRTNLHHNSLGQVITYKV
                     NDHHQIVATTDATGATTRTVRDTKHRIVSTTDPLGRTTHLTYDDEGRPVSVTLPDGSTS
                     TTTYNPDGYPVSATGPDGTTWTHTYDTAGNRTSTTDPTGATTSYTQDQRGHISTITDAL
                     GNTTRLYCNEAGLPISVTDPLGATTHYRRDAFGRTTSLTNPLGETTHMVWTVEGKLTAR
                     IDPTGATEQWTYDGEGNRTTHTDAIGQTTHFEYGHFDLLVARTDPDGVRHTFTHDTELR
                     LTQVTNPQDLTWNYTYDAAGRLISETDFDDRVLAYTHDAAGQLATRTNILGEVTTYTRD
                     TLGRITHKDTAGLVTTYVHDTSGNLQQAANRDATVTYTRDILGRVTAESVNGRTMTLTY
                     DALGRRSSRTTPTGHTTTYTYDAAGNRTALDIAGHILTFDHDAAGQELTRTIDENLNLA
                     HVWDPTGRLTTQSLTTAATGTLQSPTGAIRAENPAAAEAQRVLHRGYTYRPDGNLAAID
                     DSHTGRRTFDLDRAGRVTAVHATDWTETYAYDEAGNQTHATWPDRHANPSARGERSYTG
                     TRITRAGAIRFEHDPLGRVVLRQKTRLSRKPDTWHYTWNVEDRLTTVTTPDGTTWRYLY
                     DPHGRRIAKQRLTADSSKVVEQTDFTWDGSTLTEQTAHTPGTQKTISLTWDHRGLTPLT
                     QTERKTTALPLLSASQQVIDQRFFTIVTDLVGTPTELVSDSGGVAWRTRSTLWGTTTWN
                     SDATAYTPLRFPGQYFDPEAQLHYNFQRYYDPETARYVTDDPLGLDPSSNSVTYVDNPH
                     AWVDPLGLMSCEPKLSDPLPQGLPKAHVHAYEEIRAGRGDPQIDPRTGEQAIFQGRGAH
                     ERPWRGAREWRVPLWTKNNEARILEKTLPDGRKVMGWTTDHYRKIHPFAAPHFPDSGWN
                     "
     gene            complement(6252..6863)
                     /locus_tag="KI385_RS22415"
                     /old_locus_tag="KI385_22465"
     CDS             complement(6252..6863)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572451.1"
                     /locus_tag="KI385_RS22415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22465"
                     /product="hypothetical protein"
                     /protein_id="WP_238573954.1"
                     /transl_table=11
                     /translation="MGLIGGDGYQVEPEAFEQLTKGIKAATAELKELGFDMEAQLGRGF
                     DKLSLDNMECGDDGLAAVLDSFCDRWGWGVRTLMQDANAFSKKLGITAGMYYEQEQYVS
                     DTLKQTANAAIGDPSKTAEQLHKTSWGDIAADNPLNVDFDPMSQESMESHQRMLDTADK
                     VAEDFHSIPDRMTHPLDDPAEVTTKFHEPKGSQGQGGEGK"
     misc_feature    complement(6720..6722)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6866..7288)
                     /locus_tag="KI385_RS22420"
                     /old_locus_tag="KI385_22470"
     CDS             complement(6866..7288)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536582.1"
                     /locus_tag="KI385_RS22420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22470"
                     /product="SseB family protein"
                     /protein_id="WP_238573955.1"
                     /transl_table=11
                     /translation="MSLADEVAAVHAGQPDPAALVGEFRRTHVLIPTVNDTLLSTELDG
                     IRWLYAFTDEDALSRFALSRGSEPGTEWQYVTASGARVLDVLIPAIEGPTGVALDAGSE
                     QGALFPPVAGIVPDSAAIDVSAAGISDNAAPHRGEA"
     misc_feature    7394..7407
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.66"
                     /tool="antismash"
     misc_feature    complement(7395..7408)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.76"
                     /tool="antismash"
     misc_feature    complement(7396..7409)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.53"
                     /tool="antismash"
     misc_feature    complement(7397..7410)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.31"
                     /tool="antismash"
     gene            complement(7579..9414)
                     /locus_tag="KI385_RS22425"
                     /old_locus_tag="KI385_22475"
     CDS             complement(7579..9414)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024846.4"
                     /locus_tag="KI385_RS22425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22475"
                     /product="FAD/NAD(P)-binding protein"
                     /protein_id="WP_238573956.1"
                     /transl_table=11
                     /translation="MNHHMGPARSLCVIGCGPRGASIVERILANVPALYGDRPLDLHIV
                     DPYPPGAGRTWRTDQPGLLWMNSAAEHVTMYPDESVDCAGPPRPGPTTAGWLDAPLHDG
                     AYAARRDQGRYLRHFFDTVTRQRPASIRLFVHRARVIDLVRTAPDEALPDAPPAGRQQV
                     ILDSGEPPFLADRVVFAQGHTETLAAPTPPGLLRIGPGPADPDALDRIPPGAPVVVRGL
                     GLVFIDCLALLTEGRGGRFVRTPDGALRYLPSGREPRLYAGSRRGVPLPPKPARPLSSA
                     LPAPPAGLRFATVDACRAWLSRPGASFARDAWPLVLAELGWCHYRALFAGQPARTRMTW
                     QDFDAQYALLITDADRLAKLAREAVPDPADRFDLDRLAAPLAGLRCADTDDLQRQLHGH
                     LAEVLRRRTGPARGVETALVDALQRVGAVIEELWRAGDLDPTQVTEALGHFAIGTHLSS
                     GPPPLRAEQLLALAEAGIVTFVGPDMRVEITAGTEGAPAPAVFRATGPALPGTVHEARV
                     LLDARLAPPDPDRAADPLLRALTSRGELVPERGADGTPSGLLQLSGASLHPVDAHGTEH
                     QDRIIAGPAQFPRPGTNAVYFRQNDTIARSLLGGD"
     gene            complement(10001..12682)
                     /gene="lanKC"
                     /locus_tag="KI385_RS22430"
                     /old_locus_tag="KI385_22495"
     CDS             complement(10001..12682)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="KI385_RS22430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22495"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_238573957.1"
                     /sec_met_domain="micKC (E-value: 9.5e-231, bitscore: 767.2,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 1.8e-05, bitscore: 23.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2e-07, bitscore: 29.1,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDGAESFALADRTFFDWPGNWNTEATRFPAPPLPDGWTLDENEA
                     WTFCRPPEDQLPDQGWKIHVSAAPDDARRTIADVAAYCTRHGLAFKYLKSANVLRALSR
                     KYAQRSSAGKLLTVYPVDEADLARTLEGLDAIVGGRPGPYVLTDLRFRQGPLYVRYGGF
                     RTRYMEDADGELVTAFRRPDGTPEPDRRTPVFHTPDWVAIPDILKDSLAARQAVDDFPY
                     RITGALQFSNGGGVYRAAPLGADALGAGETGVVLKEGRPYSGTDGVGRDAVSRLAHEHR
                     MLERLAGLPGIPRTFGTLQVRDHLFLVLEDIAGQDLQTWLAAHHPLTVPDPDEQAVADY
                     RDRALALLGRIEALVAAVHERGIRIGDLHPGNLIIKPGDEPVLLDFEVADEIDRATPSS
                     LGAPGFHRADAIGADGDHYALAAIGLWFFLPLAALGGLAPDKAPALLATAAERYGLPNS
                     LVSRLAPQLAPNDDTTSPLTSLPGAFPPSGVLESLGRGLRDSATPHRKDRLYPGDFEQF
                     VEGGAGFGHGAAGVLWTLHTALGQRDEEGVAWLRAAVDRVPAERIGFYDGLHGMAYVLS
                     ELGDDEAARRALDRADGQLSVRHCPSLYRGLSGVGLNLLHFADALDSDALRQQALGLAD
                     RVTQRLAAARTEPVERKRRRGSKDAAGLMYGWSGAALFLLRAHQATGDPGLLDEAVHAV
                     HRDLARCSPGPQDTLQVDEGFRLLPYLDNGSAGIALVAAELLELRDDDRIREALPALLR
                     ACAADFVIESGLLGGRAGLLATLATLRDRVSLPPEATERHLRRHLTNLGQHAMTRNGAV
                     VFPCDGRARISMDLAGGSAGVLLALSATERGTPLLPFLTDSRSAAAVHSAAPGRGGGAT
                     SAATLAAPSGAAGTAHRGREVS"
     gene            complement(12679..13407)
                     /locus_tag="KI385_RS22435"
                     /old_locus_tag="KI385_22500"
     CDS             complement(12679..13407)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="KI385_RS22435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22500"
                     /product="GNAT family protein"
                     /protein_id="WP_238573958.1"
                     /transl_table=11
                     /translation="MQGRLVTLEWPGDDDWAAIASWLRPGSPAAVLSGDWELLGAAEIE
                     QANRSGRVHNLVIRTKDGERIGAVSYQRSGRIGGYTVGGAIGSPDLWRRGYGAEAVVLL
                     VDYLFHQLDAHRVQVTTAGYNKGIIRLMTKTPFVVEGILRDHCYLDGQYHDAIVWGLLR
                     DEHYASLKPSDDNRVLAVGLDDFIPEADKSQARAVLAEHLATAGRRTALTAYLDHEATP
                     LHEAGPHDEDEPAGAERGAA"
     gene            complement(13423..14682)
                     /locus_tag="KI385_RS22440"
                     /old_locus_tag="KI385_22505"
     CDS             complement(13423..14682)
                     /EC_number="2.3.1.179"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (9-417). E-value:
                     4.2e-58. Score: 189.1. Matches aSDomain:
                     nrpspksdomains_KI385_RS22440_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016578549.1"
                     /locus_tag="KI385_RS22440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22505"
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="WP_238573959.1"
                     /sec_met_domain="t2fas (E-value: 2.2e-143, bitscore: 476.9,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 9.8e-49, bitscore:
                     165.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVRAERRRVVVTGTGVVSPVGNTTADFWAALLAGRSGVKTLTRF
                     DTSGLPVRIGGEVTGFDTTGYLTPQEARRSDSFTQYAVVAATQALRAAGLDEPAGIDPY
                     RFAAVIGSGYGAANSIQQQYDVLQRQGSRRVSPYHSVLTAIDHPASLLSIKYGIGGPSC
                     AVSAACATGAVAIGEAAELIRHGRADIALAGGADDALTAVDLAGTANAQALSRRNDDPE
                     GASRPFDRDRDGFVMAVGATVLTLEEAGHAERRGAPILAEVAGYAATTDAHHATAPDPT
                     GAGAVRAMRYALADAGRTPEDVGQISAHGTGTVLNDRIEAAALREVLGPDHLRRTPITA
                     VKSMTGHMLGASGAAEAAAAVLSLRDRKIPPIRNCDHPEEPDLDLVVKGARDWDGDVVL
                     SNSFGFGGHNAVLVLTRYTG"
     aSDomain        complement(13432..14655)
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KI385_RS22440_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="4.20E-58"
                     /label="KI385_RS22440_PKS_KS.1"
                     /locus_tag="KI385_RS22440"
                     /protein_end="417"
                     /protein_start="9"
                     /score="189.1"
                     /tool="antismash"
                     /translation="VVVTGTGVVSPVGNTTADFWAALLAGRSGVKTLTRFDTSGLPVRI
                     GGEVTGFDTTGYLTPQEARRSDSFTQYAVVAATQALRAAGLDEPAGIDPYRFAAVIGSG
                     YGAANSIQQQYDVLQRQGSRRVSPYHSVLTAIDHPASLLSIKYGIGGPSCAVSAACATG
                     AVAIGEAAELIRHGRADIALAGGADDALTAVDLAGTANAQALSRRNDDPEGASRPFDRD
                     RDGFVMAVGATVLTLEEAGHAERRGAPILAEVAGYAATTDAHHATAPDPTGAGAVRAMR
                     YALADAGRTPEDVGQISAHGTGTVLNDRIEAAALREVLGPDHLRRTPITAVKSMTGHML
                     GASGAAEAAAAVLSLRDRKIPPIRNCDHPEEPDLDLVVKGARDWDGDVVLSNSFGFGGH
                     NAVLVLTRY"
     CDS_motif       complement(14158..14205)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KI385_RS22440_0001"
                     /evalue="3.70E-02"
                     /label="PKSI-KS_m3"
                     /locus_tag="KI385_RS22440"
                     /protein_end="175"
                     /protein_start="159"
                     /score="7.1"
                     /tool="antismash"
                     /translation="GPSCAVSAACATGAVA"
     gene            15147..15326
                     /locus_tag="KI385_RS22445"
                     /old_locus_tag="KI385_22510"
     CDS             15147..15326
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538451.1"
                     /locus_tag="KI385_RS22445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22510"
                     /product="DUF5708 family protein"
                     /protein_id="WP_128503912.1"
                     /transl_table=11
                     /translation="MKGIAVGIVLAIVGLILWLTTKEVDTGVVSLHKAGLVLAIVGGAE
                     ALFALLGLGKKAKK"
     gene            complement(15385..16632)
                     /locus_tag="KI385_RS22450"
                     /old_locus_tag="KI385_22515"
     CDS             complement(15385..16632)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.4"
                     /locus_tag="KI385_RS22450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22515"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_281066887.1"
                     /transl_table=11
                     /translation="MPELADTGRRIKELRVSAGMTQHDLAGSEMSSSYISLVERGKRIP
                     SGRALKILAQRLGVGVDEISRTAEHVETTSRVRRLDLVGRLVAARRQWEGGDAEGALRE
                     FRALAEIDPAGRQDDVFTEAQLAIAEILGTLGRADEGAEVLLRMLDALTPAPYAEARLR
                     ALIALADLLESAGRVQDGLRYALTGSLECADRRPGTGFHSLLVLDVLTRCAYWSGCPEW
                     APDTDHCRHSAEGVLPGPRAAIDLHRALDLRDRGEMERAAALLGECARRVTPTAGFPLW
                     EKINGHYALLLLHRGETAAARSIVERGLVVASVTQEPEFPLWLTTADAVCAEAAGDPGR
                     VFALGVELAALPDTGRGHEKAAALLEIAAACERLGDRERAAGHFRYSAELFRRAQAYRH
                     AERARERLTDLIEKRD"
     misc_feature    complement(16621..16636)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.44"
                     /tool="antismash"
     misc_feature    16678..16694
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.52"
                     /tool="antismash"
     misc_feature    16717..16732
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.31"
                     /tool="antismash"
     misc_feature    complement(16728..16743)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.82"
                     /tool="antismash"
     gene            17004..17660
                     /locus_tag="KI385_RS22455"
                     /old_locus_tag="KI385_22520"
     CDS             17004..17660
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021443.4"
                     /locus_tag="KI385_RS22455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22520"
                     /product="DUF1707 domain-containing protein"
                     /protein_id="WP_238573961.1"
                     /transl_table=11
                     /translation="MTQPQRPDLHKDVAPSPATSRSVLASDAEREDMVERLREATAEGR
                     LTLEELAERSEAAYLARTREELRSVGEDLPHVTPPESSASATGQRSFRAVFGDVTHHSP
                     SLEHGIEATAVFGDLTLDLCASPAPSTGELTIEARAFVGDVHLLLPEGVRVEMNCSKVL
                     GDLRNVTREHSGPEAVTPLIRITGSAVLGDIVVAHPNSDRRTYWQKWLDERRGRA"
     misc_feature    17139..17141
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17753..18511
                     /locus_tag="KI385_RS22460"
                     /old_locus_tag="KI385_22525"
     CDS             17753..18511
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358668.1"
                     /locus_tag="KI385_RS22460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22525"
                     /product="ABC transporter permease"
                     /protein_id="WP_238577799.1"
                     /transl_table=11
                     /translation="MARHTGALVRRNLLQIRQNPESMADALLMPIVLTVLFVFVFGGSI
                     GAGGDRAQYTAFLVPGLMVILGMTIAMAVGTGVNDDFRTGLMDRFRTMPIARSSVLVAK
                     VVVETGRMLVAIAVLLIVAAVLGFDFSGRWPGLLAAIGLTAVFGTSLIWIFMLLGLTLR
                     TAQAIQALSVVVLTPLQFGSSIFVPPSTMPDWLQAFTRINPLTHMADAARGLALGEGPV
                     AGPVLWTLVWSLGLTAVTAPLAIAKFRAKT"
     misc_feature    17786..17800
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.48"
                     /tool="antismash"
     gene            complement(19027..20742)
                     /locus_tag="KI385_RS22465"
                     /old_locus_tag="KI385_22530"
     CDS             complement(19027..20742)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981568.1"
                     /locus_tag="KI385_RS22465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22530"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_238573962.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 5.6e-44, bitscore:
                     148.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.1e-18, bitscore:
                     65.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTYTHPTAWAAIADHLHHLGSEVVFGLPGDDMALLGELERSDTT
                     VVLCRDQRNAVFMATGYALAAGRPGVCVIGKGPALTNALTGVLEARSAAAPLILIADGT
                     RLDRLGTGAFQELDQLTAIRPYVKWAARVDHADRLPGALEKAAALAVNGTPGPVYLELA
                     EQIAAEPVTRTGPWRPAAPQRPAPDQDALAATAERIAAAERPLLLVGGGARHRNDGRRI
                     EHFAEQLGAGIFSTASGRGTVAEDHPLYCGVSGLYTVAPMDALWREADLVIALGSRLEE
                     TATFGWPEDAAQLPVVQAVLGEESLVMERPGAYVLGDAGRIVDGWAGLLADRRPPRDWP
                     ERVRTVRAALAGRAADRAEEAVKHAPEGAVPVARVLAALDRVVPADRVLVQENGLQDMW
                     SYFFPHWSLGSEGGSVVPSEQTPLGFGAAAAVGVRLAEPAGRPVVAVVGDGAFNLFRGE
                     LPTVADAGAAVLYVVLDNGGYGWLQSNLDRVSGTGSRFAFTTSRPTGTEGLTSAYGLGY
                     GRVTDADQLEPALTAAWRQVAAGTCAVVEVAVALADTPPGMSGSAGDFPEREDA"
     gene            complement(20739..21980)
                     /locus_tag="KI385_RS22470"
                     /old_locus_tag="KI385_22535"
     CDS             complement(20739..21980)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003981569.1"
                     /locus_tag="KI385_RS22470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_22535"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_238573963.1"
                     /sec_met_domain="Aldedh (E-value: 1.5e-22, bitscore: 78.7,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSAPAWPTVAAEPEDSIDSRRAAALHRVRDFLVNDAGTVHELLC
                     EISTHRAARYEIESTVATLDGALDEVAAHRPGRVPRLAAFMPSNVLLYSYALYLLVPAL
                     YTDRLVFRPSSRVKDQMRRLHTLLAEQHGLPITLSGASQREFLQEQVLPADVVVFTGAY
                     ANAEQIRPQLSPGQLFLFLGSGVNPFVVAPGADVEQAARDAIAIRVLNTGQDCLGPDLF
                     SVHESLLAPFVDALVSEVKGMRYGPYTDPDADYGPIFYESALEDGAQFLARNRGGIVHG
                     GHVDFRTRRLDPTVVVGEDVTPRTHVPEFFAPIFNVAGYRDQDALAATLTTGMFTERAL
                     GSSVYGHAPGLVEALRRRTTVTLDTTLLSIDDGNAPFGGYGRMANYISDGREVRAEPVL
                     ISKAVAAHRPGAGR"
     misc_feature    22026..22041
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.59"
                     /tool="antismash"
     misc_feature    22027..22043
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.61"
                     /tool="antismash"
     misc_feature    complement(22032..22045)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.73"
                     /tool="antismash"
     misc_feature    22357..22371
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.7"
                     /tool="antismash"
     misc_feature    22599..22613
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 tcgcggatga gcccggggag caaagccccc acctcggtac ggttgcgatc agacgtgtgc
       61 cacaggcgcc atgtctgatc gacacggcct tgcagcacgg ccggctccag gggccccgtg
      121 gcagccacgg tcagggagcg gttcatgacc gcagtccaga tctcgggcat ggccggatgg
      181 ttcatcctgc ctagcggtac caactgcgcc gggccgccct cgccgtctcc ggtgagaacg
      241 gacagatcgg agacctgaag cgcggcacct aggcgcaaca gaagcgtatg agaacggagt
      301 tcgcgttccc ccgtctcgat cttcttcaac caatcggggc ctcgcccaca gaggtgagcg
      361 agggtggcac gggtcatgcc acgcgactcc cgaagaaccc tgatccgctc gccggtactg
      421 agctcgtctg acagatccat gcgtgcccct taggtggcgt ggccgtccca gccagcgtac
      481 ggctgggacg gggtccgtgg gcagatgcac ggtgcttggc tctgctctcg cccgccggcg
      541 ccgtcgacac gttggcggct cacctggcgc aacgagccga tgcggattgc tgggaatatg
      601 aatatcgagg aactcgcatg gaggcattca tgccaatggc aatgttaccg acattcatcg
      661 aaagacgaca gtgattttaa actctcgcag cgtgtcgatg atcgacgaaa attcggccga
      721 gccgaggctt tcccttgccg cgccggaatc tctccacgcg aggagaaaag gctcactacg
      781 ggaaagacaa tcggctagcg cgtcaaggtt cgacccaaag taaccccctg ggccgttaac
      841 ggcctcccca agggcacagt agaagctcgc catgctggcc acatcgccgc catcaatttc
      901 atattgcgac ttctcactgt accgaatcgc cgagcgccct gcaccaaacc aagccgtctg
      961 cacaacatgg agccagctat cgtgggcttc gattggatat ttcttccatt cccccaaggc
     1021 tggccgcctt tctgcggccc atttacgcca aaaatccccc gcaaacggaa atgggctggc
     1081 gtagccgaaa aaggatgcag tgaggtcgca tgcccttgca tcgtcggacg cacccgtcct
     1141 tcgaatatcc gtcacttcaa tgcggcccac atagtaggag ccaataactt cactgcagcg
     1201 actcagcacc tgcaactcta cgtcgtcaaa caggctgggt gtgatgccag gcgcagggga
     1261 gacgccaacc aggcagattt ccgaagactc ttccctcgat gcagggacga aaaatccctg
     1321 catgtcgatt gccgtgaaga tctcgcgccg caactcgtct tcgatcaagc gatacaaggg
     1381 gagccgagga gccatttcag caagcatccg attgatactc ctttcttgca agagtatccc
     1441 ctattggcct cgagatacaa gtgcaggact gctggatggg acacatttgg cggtcctttc
     1501 gattccccaa aggagttaat tccatccact atcagggaag tgaggtgcag cgaaggggtg
     1561 aattttgcgg taatgatccg ttgtccaccc cataactttt cgaccgtccg gaagggtctt
     1621 ctcaagaatt cttgcctcat tattcttggt ccagagagga accctccatt ccctagcccc
     1681 tcgccagggt cgctcatgcg cccctctccc ttggaagatt gcttgctctc ctgtcctggg
     1741 gtcaatttga ggatctccgc gccctgccct gatttcctca taggcatgaa catgcgcctt
     1801 tgggagccct tgcggcaacg gatctgaaag tttgggctcg caagacatga gcccgagtgg
     1861 gtcgacccag gcgtgagggt tatctacata ggtcacggaa ttggacgatg gatcgagacc
     1921 gagagggtca tcggtgacgt atcgcgcggt ttctgggtcg tagtaccgct gaaagttgta
     1981 gtggagctgg gcttccgggt cgaaatattg gccgggaaac cgcaatggcg tgtaggccgt
     2041 ggcgtcagag ttccaagtgg tcgtccccca gagagtcgac cgcgtgcgcc aggcgacgcc
     2101 accggagtcg gatacaagtt cggtgggagt gccaacgagg tcggtgacaa tggtgaagaa
     2161 gcgttggtcg atcacctgct gggaagcaga gagtaggggt agcgccgtgg tcttgcgttc
     2221 ggtttgagtg aggggtgtca ggcctcggtg gtcccaggtg agtgagatgg tcttttgggt
     2281 gcccggggtg tgggcggttt gttcggtgag cgtcgagccg tcccaggtga agtcggtttg
     2341 ctctacgacc tttgaggaat cagcggtcag gcgttgtttg gctattcggc ggccgtgggg
     2401 gtcgtagagg tagcgccagg tggtgccgtc gggggtggtg acggtggtga ggcggtcttc
     2461 cacattccag gtgtagtgcc aggtgtcggg tttgcgggag agacgggttt tttggcggag
     2521 tacgacgcgg ccgagggggt cgtgttcgaa gcggatggcg ccggcgcggg tgatacgggt
     2581 gcctgtgtat gacctttcgc ctcgggctga ggggttggcg tggcggtcgg gccaggtggc
     2641 gtgggtttgg ttgccggctt cgtcgtaggc gtaggtctcg gtccagtcgg tggcgtggac
     2701 ggcggtgacg cggccggcgc ggtcgaggtc gaaggtgcgg cggccggtgt gggagtcgtc
     2761 gatcgcggcg aggttgccgt cggggcggta ggtgtagccg cggtggagga cccgttgggc
     2821 ttcggcggcc gcagggttct ctgcccggat cgcgccggtg ggggactgga gagtgccggt
     2881 ggctgctgtg gtgagggact gggtggtgag gcgaccggtt gggtcccaga cgtgggcgag
     2941 gttgaggttt tcgtcgatgg tgcgggtgag ttcttggccg gcggcgtcgt ggtcgaaggt
     3001 gaggatgtgg ccggcgatgt ccagggcggt gcggttgccg gcggcgtcgt aggtgtaggt
     3061 ggtggtgtgg ccggtagggg tggtgcggga gctgcggcgg cccagagcgt cgtaggtgag
     3121 cgtcatggtg cggccgttga ccgattcggc ggtgacgcgg cccaggatgt cgcgggtgta
     3181 ggtgacggtg gcgtcccggt tggctgcttg ttgcaggttg ccgctggtgt cgtgaacgta
     3241 ggtggtgacg agaccggcgg tgtccttgtg ggtgatgcgg ccgagggtgt cgcgggtgta
     3301 cgtggttact tcgccgagga tgttggtgcg ggtggcgagt tggcctgcgg cgtcgtgggt
     3361 gtatgccagg acgcggtcgt cgaagtcggt ctcggatatg aggcggccgg ctgcgtcgta
     3421 ggtgtagttc caggtcaggt cttgggggtt ggtgacctgg gtgaggcgga gttcggtgtc
     3481 gtgggtgaag gtgtggcgga cgccgtcggg gtcggtgcgg gccaccagga ggtcgaagtg
     3541 gccgtattcg aagtgggtgg tctggccgat ggcgtcggtg tgggtggtgc ggttgccctc
     3601 gccgtcgtag gtccactgct cggtggcgcc ggtggggtct atgcgggcgg tgagtttgcc
     3661 ttcgaccgtc cacaccatgt gggttgtttc gccgaggggg ttggtgaggg aggtggtgcg
     3721 gccgaaggcg tcgcggcggt agtgggtggt ggcgcccagc gggtcggtga ctgatatcgg
     3781 taggccagcc tcgttgcagt agaggcgggt ggtgttgccg agggcatcgg tgatggtgga
     3841 tatgtgcccg cgctggtcct gcgtgtagct ggtggtggcg ccggtggggt cggtggtgga
     3901 ggtgcggttg ccggcggtgt cgtaggtgtg ggtccaggtg gtgccgtccg gacctgtggc
     3961 gctgacgggg tagccgtcgg ggttgtaggt ggtggtggag gtcgacccgt cggggagggt
     4021 gacgctcacc gggcggccct cgtcgtcgta ggtgaggtgg gtggtgcggc ccaaggggtc
     4081 ggtggtggac acgatgcggt gtttggtgtc gcggacggtg cgggtggtgg cgccggtggc
     4141 atcggtggtc gcgacgatct ggtggtggtc gttgaccttg taggtgatga cctggccgag
     4201 ggagttgtgg tggaggttgg tgcgtaggcc ggttgtcggg tcgggctcgc cccaggtgaa
     4261 gttggcgcgg aggtggcctt cgatgccgcc ttgtgaggtg cagcggtcct ggtcgtcgta
     4321 gacgtagtgg tagctgctgt tgttggtgtc ggtccaggac gtgatgcggc cggcgtcgtc
     4381 gtaggtgaag cggaggggga ggccggagga gttggtgacg gtggtgaggt tgcccagctc
     4441 gtcgtagccg taggtgacca ggagttggtc gctgccgtcg gcggcggcgc cggccaggtg
     4501 gagggcggtg atgcggccct cgtcggtggt gaggaggagg cggtagccgg cgctgtgggt
     4561 gatggcggtg ggggtgccgt ctgcggtgta gtcgaaggtg tggtgattgc cgcggcggtc
     4621 ggatatctcg tcgaggacgg cgaggttttc ggcgtaggtg gtgaagtagc ggcgggtgcc
     4681 ggtgaccggg tcggtgagga ggtagtcgcc gtccggggtg agttcgaggg gtgcgccgtc
     4741 gccctctatg gggagggtgg ggacgccgac cgcggggtgg gggtagagga ggaagttgcc
     4801 ctcttcgccg atgaggatga cgccctcgga gtcgatttcc aggcgctggt cgacggtgga
     4861 catccaggtc gggccgaacc agcggccggt gcggtaggac gactcgaagg ttcgggtgaa
     4921 ggcgaggggg aggctgccgg ggagggtgat gtcggtctgc ggcaggtgca tgcggccggt
     4981 ggccatgtcg atggggtcgc tgccgaaggt cttgcaccag gcagtacgca gccggtcccg
     5041 gacggtgcgc ttgccgccct ccttagcagc cgtccgcgcg gcggccttgg cggcgttctt
     5101 cgcgcctgcc tttgccaccc ccttggccag tgcgcccgcg cccttgccgc cgaccgcgtt
     5161 gacgatcgca gcgctgaacg agtcgaacgg gtcgctgccc cagcccgagc cgagcatgcc
     5221 cttggcggta tcgatggggt ggagcccggc ctgggccagg cccatgagca gggtggcggt
     5281 gttgcccgcg tacttccagg ggtgggtgat gttgtagggg tccagtgggt tgatcgtccg
     5341 ggccagcttg agggtgtcgg ccccggcctt gagagcgccg ccgaccatat gcacgtgcgc
     5401 gaggacgaac gcctcaccgc cgtccttgag ggccgcgccc gccagctccg tgaacgcggg
     5461 cttgtccggg gcgtgggcca aggcgccctt gatggcgtta cgagcccggt cggccgcttc
     5521 gttgcgctgg ctgcgggcgt ccttgaggat gtcttcggcg gcctcgcggc cctccttgcc
     5581 cacgtcgccg gggtcggagg gagcctgcgg ttcggcgccc gcgtcggtgc ctcgtgaggc
     5641 gaggtactcg tacgcggaat gacgctcccg gtagctgtcg tactgggact cgtactcgct
     5701 ctgggcacgt tcggcggcct gctgcgcctt gcggtacttc tcgatcgcgt cgacggcctt
     5761 tccctgcgcc caggtcaccg tctccgcata cgacttcagg gccttggagg cgtcgtcgca
     5821 ggcgtcggcg gcgtgcatcc actgcttggg gtgcatgtcg aacgcctcgc ggaaggcgtc
     5881 ggcggccttg ccgctccagt ggtggcccga gccgagcttg cgcatgccgt tggcgacgcg
     5941 gtcgaaggcg gccgagaagt ccttcaggtg ggaggccgtc tcgttgatct tctcgacgtc
     6001 gccgtggatg agttccttgg ggtcttcggt ctcaccgagc tgccgttcat cgacgtgggc
     6061 gcccagggcg ccggccaggt cggcgccggc ggtgcggacg gcgtgtccgg cgtcgtcgag
     6121 accgacggtc tccagcgcgt cgccggccag gtcggagccg tgctcgacca gctcgcccgc
     6181 gccgcgctcg acggcgtccg tgaacttgct cgcgccgtcg cctatcgcgt tcaaaccatc
     6241 gccgagccag ttcacttgcc ctcacccccc tgtccctgcg aacccttcgg ctcgtggaac
     6301 ttggttgtga cctcggcggg atcgtcgagc gggtgggtca tccggtcggg gatggaatgg
     6361 aagtcttcgg caaccttgtc ggccgtgtcc agcatccgct gatgcgactc catcgactcc
     6421 tgggacatcg ggtcgaagtc gacgttgagg gggttgtccg cggcgatgtc gccccaggac
     6481 gtcttgtgca gctgctcggc tgtcttggac gggtcgccga tcgccgcgtt cgcggtctgc
     6541 ttcagcgtgt ccgagacgta ctgctcctgc tcgtagtaca tgccggcggt gatacccagc
     6601 ttcttggaga atgcgttggc gtcctgcatc aacgtgcgca cgccccagcc ccagcggtcg
     6661 cagaaggaat cgagtacggc ggccaggccg tcgtcgccgc attccatgtt gtccagcgat
     6721 aatttgtcga aaccgcggcc aagttgggcc tccatgtcaa agcccagctc tttgagttcg
     6781 gccgtcgcgg ccttgatgcc tttggtgagc tgctcgaaag cctcaggctc gacctggtac
     6841 ccgtctccgc cgatcagacc cattcctacg cttcccccct gtgcggtgcg gcgttgtccg
     6901 atattccagc cgccgatacg tcgatggccg cgctgtcggg gacaattccg gccaccggcg
     6961 ggaagagcgc accctgttca ctgcccgcgt ctagggccac ccccgtaggg ccctcgatgg
     7021 cgggaatcag cacgtcaagg actcgggcac cggacgccgt cacgtactgc cactccgtgc
     7081 cgggctcact gccacgggag agagcgaagc gggaaagggc gtcctcatcg gtgaaggcat
     7141 atagccagcg gatgccgtcc aactccgtcg agaggagcgt gtcattgacc gtcggaatca
     7201 agacatgcgt gcgccggaat tcgcctacca gcgcggctgg atccggttgt cctgcatgaa
     7261 ctgccgctac ctcgtcggcc aatgacacgg cgggcccctc ccccgatttt cacctcaact
     7321 gctcggacca ctctcgcata tggcactgac aacgccgccg gagacactcg gaggggaaac
     7381 cggtcgccgg ttctttttat tttcaaatag gggtgtgggt gagtgggtga taaatggggc
     7441 gagttgggaa gggctggtga ttttgggcgg gaatggcacc ggctgcggcg gcccgatggg
     7501 tggtgcccga tgggtggtgg gggtgcagcc gcttgctcaa cgcttccgtc agaacgacac
     7561 cctcgccctc cgccccgctc agtcgccgcc gagcaagctg cgcgcgatgg tgtcgttctg
     7621 gcggaagtag acggcgttgg tgcccgggcg ggggaactgg gccgggcccg cgatgatgcg
     7681 gtcctggtgc tcggtaccgt gcgcgtcgac cgggtgcagg ctcgctcccg acagctggag
     7741 caggccgctc ggggtcccgt ccgcgccacg ttccggcacc agttcacccc gggacgtcag
     7801 ggcgcgcagc agggggtcgg cggcccggtc ggggtcgggc ggtgccagcc gggcgtcgag
     7861 gaggaccctc gcctcgtgga cggtgccggg gagggcgggg ccggtggcgc ggaagacggc
     7921 gggggccggg gccccctcgg tgccggctgt gatctccacc cgcatatcgg gccccacgaa
     7981 cgtcacgatg cccgcctccg ccagcgccag cagctgctcg gcgcgcagtg gcggcgggcc
     8041 cgagctgagg tgcgtaccga tcgcgaagtg gcccagcgcc tcggtgactt gggtgggatc
     8101 gaggtcgccg gcgcgccaca gctcctcgat gaccgcgccg acccgttgca gggcgtcgac
     8161 caacgcggtc tcgacgccgc gcgcgggtcc ggtacggcgg cgcaggacct cggcgaggtg
     8221 accgtgcagc tgtcgctgga ggtcgtcggt gtcggcgcac cgcagaccgg ccagcggcgc
     8281 ggccagccgg tccaggtcga aacggtccgc ggggtcgggc accgcctcgc gggcgagttt
     8341 ggccagccgg tcggcgtcgg tgatcagcag ggcgtactgg gcgtcgaagt cctgccaggt
     8401 catacgggta cgggcgggct gcccggcgaa gagggcgcgg tagtggcacc agcccagttc
     8461 ggccagcacc agcggccagg cgtcgcgggc gaaggaggcg ccgggcctgg acagccaggc
     8521 gcggcaggcg tcgacggtgg cgaagcgcag accagcgggc ggggcgggca gggccgatga
     8581 caaggggcgc gccggtttcg ggggcagcgg tacgccgcgg cgggagcccg cgtacagccg
     8641 gggctcgcgg ccggagggca gatagcgcag cgcgccgtcg ggggtgcgga cgaagcggcc
     8701 gccgcggccc tcggtcagca gcgccaggca gtcgatgaag accaggccga ggccgcggac
     8761 gacgacgggc gcgccgggcg ggatgcggtc cagcgcgtcg gggtcggcgg ggccggggcc
     8821 tatgcgcagc aggccgggtg gcgtgggggc ggcgagggtt tcggtgtgtc cttgggcgaa
     8881 gaccacccgg tcggcgagga aggggggttc gccggagtcc aggatcacct gctgacggcc
     8941 ggccggcggt gcgtccggga gcgcctcgtc gggggccgtc cgtaccaggt cgatcactcg
     9001 cgcgcggtgg acgaacagcc ttatcgaagc gggccgttgg cgggtcacgg tgtcgaagaa
     9061 gtgccgcaga tagcggccct ggtcgcggcg ggcggcgtag gcgccgtcgt gcagcggggc
     9121 gtcgagccag ccggcggtgg tggggccggg gcgcggcggt cccgcgcagt ccacgctctc
     9181 gtcggggtac atggtgacgt gctcggcggc ggagttcatc cacagcaggc cgggctggtc
     9241 ggtgcgccag gtgcggccgg cgccgggtgg gtacgggtcg acgatgtgca ggtccagggg
     9301 gcggtcgccg tacagggcgg ggacgttggc gaggatccgc tcgacgatcg aggcgccgcg
     9361 gggtccgcag ccgatgacgc agagggagcg ggccgggccc atgtggtggt tcaactggcc
     9421 tccgtccgtg ggcctccgtc cgtgaaactc cgtaaaacac aggggcccgg tggcccgtgc
     9481 cgaagcacgg gaccaccggg cgccgtgtca gcaaccgccg ctgatcgtgg agccgagcgc
     9541 ctgggcgtca cgctcgcccg gcacctccag gccctgaagg tccatgatgg tcatctacga
     9601 cacctccctt ccgcggatcg aaagacgtgt gtaccgtggg cacacggtgc gtggtggaga
     9661 ccgaacaccg tgtgttgagg cactgtgtgg tcagctgcgt cagcagccgc cgctgacggt
     9721 ggagccgagc gcctgagcgt cacgctcgcc cggcacctcc aggccctgaa ggtccatgat
     9781 ggtcatctac gacacctccc ttccgatgct tcgttgtggc ggatggtcac ggtggtgacg
     9841 taccaggtgc cgttgcggga cacctggagc cggtggaccg tgcatgacgg tgcacggtcc
     9901 gcccggcatc acgtcagcag ccgccgctga cggtggagcc gagcgcctga gcgtcacgct
     9961 cgcccggcac ctccaggccc tgaaggtcca tgatggtcat ttacgacacc tcccttccgc
    10021 ggtgcgcagt gcccgctgcc ccggacgggg cggcgagggt ggcggcgctc gtggcgccgc
    10081 cgccgcgtcc cggggcggcc gagtgaacgg ctgccgcgga gcgcgagtcg gtgaggaacg
    10141 ggagcagcgg ggtgccccgt tcggtggcgg acagcgcgag cagaactccg gcgctgccgc
    10201 cggccaggtc catggagatc cgggcgcggc cgtcgcaggg gaagaccacc gctccgttcc
    10261 gcgtcatggc gtgctggccc agattggtca gatggcggcg cagatggcgc tcggtcgcct
    10321 ccgggggcaa ggacacccgg tcgcgtagcg tcgccagggt ggcgagcagt cccgcgcggc
    10381 cgcccagcag cccggactcg atgacgaagt cggcggcgca ggcgcgcagc agggcgggca
    10441 gcgcctcgcg gatccggtcg tcgtcgcgca gctccagcag ctcggccgcc accagcgcga
    10501 tccccgcgct gccgttgtcg aggtagggca gcagccggaa tccctcgtct acctggaggg
    10561 tgtcctgtgg gccgggcgag cagcgcgcga ggtcgcggtg gacggcgtgt accgcctcgt
    10621 ccagcaaccc ggggtccccg gtggcctggt gggcgcgcag gaggaagagg gcggcgcccg
    10681 accagccgta catcaggccg gcggcgtcct tcgagccgcg tcggcgcttg cgctcgaccg
    10741 gttcggtgcg ggccgcggcg agccgctggg tgacgcggtc ggcgaggccg agtgcctgct
    10801 gccgtagtgc gtcgctgtcc agcgcgtcgg cgaagtgcag caggttcagg ccgacgcccg
    10861 acaggccgcg gtagaggctg gggcagtggc gtacggagag ttgaccgtcg gcccggtcga
    10921 gggcgcgccg ggcggcctcg tcatcgccca actcgctcaa gacgtacgcc attccgtgca
    10981 gaccgtcgta gaagccgatc cgctcggcgg ggacccggtc gacggcggcg cgcagccagg
    11041 cgacgccctc ctcgtcacgc tgtccgagcg cggtgtgcag cgtccacagg acgccggccg
    11101 caccgtgtcc gaagcccgcg ccgccctcga cgaactgctc gaagtcgccg gggtagagcc
    11161 ggtccttgcg gtgcggggtg gcgctgtcgc gcagcccgcg gccgagggat tccagcacac
    11221 cggagggtgg gaacgcgcct ggcaaggagg tgagggggga ggtcgtgtcg tcgttggggg
    11281 ccagttgcgg ggccagccgc gacaccaggg agttgggcag tccgtaccgc tcggccgcgg
    11341 tggccagcag cgcgggggcc ttgtccgggg cgaggccgcc gagcgcggcc agcggcagga
    11401 agaaccacag tccgatggcg gcgagcgcgt agtggtcgcc gtccgcgccg atcgcatcgg
    11461 cacggtggaa gccgggggcg ccgaggctgc tcggggtggc ccggtcgatc tcgtcggcca
    11521 cctcgaagtc caggagtacg ggctcgtcgc cgggcttgat gatgaggttg cccgggtgca
    11581 gatcgccgat ccggatgccg cgttcgtgga cggcggcgac cagcgcctcg atccggccga
    11641 gcagggccag cgcgcggtcc cggtagtccg cgacggcctg ttcgtcgggg tcggggacgg
    11701 tcagcgggtg gtgggcggcg agccaggtct ggaggtcctg gcccgcgatg tcctccagga
    11761 ccaggaagag atggtcgcgt acctggaggg tgccgaaggt gcgcgggatc ccggggagtc
    11821 cggccagccg ctccagcatc cggtgctcgt gggcgagccg gctgaccgcg tcgcggccga
    11881 caccgtcggt cccggagtag ggccggccct ccttgaggac gacgccggtc tcacccgcgc
    11941 cgagggcgtc ggcgccgagc ggtgcggcgc ggtagacgcc gccgccgttg gagaactgca
    12001 gcgccccggt gatccggtag gggaagtcgt ccacggcctg ccgggcggcc agcgagtcct
    12061 tgaggatgtc ggggatcgcg acccagtcgg gggtgtggaa gaccggcgta cggcggtccg
    12121 gttcgggtgt gccgtcgggg cgccggaagg ccgtcaccag ctcgccgtcg gcgtcctcca
    12181 tgtagcgggt gcggaagccg ccgtagcgta cgtagagcgg gccctggcgg aagcgcagat
    12241 cggtgaggac gtacgggccg gggcggccgc cgacgatcgc gtccagtcct tcgagggtgc
    12301 gggccaggtc ggcctcgtcc acggggtaga cggtcagcag tttgccggcg gaggagcgct
    12361 gggcgtattt gcggctcagg gcgcgcagga cgttggcgct cttgaggtat ttgaaggcca
    12421 ggccgtgccg ggtgcagtag gcggcgacgt cggcgatggt gcggcgggcg tcgtcggggg
    12481 ccgcgctgac gtggatcttc cagccctggt cggggagttg gtcctcgggc gggcggcaga
    12541 aggtccaggc ctcgttctcg tcgagggtcc agccgtcggg gaggggcggg gcggggaagc
    12601 gggtggcttc cgtgttccag ttgccgggcc agtcgaagaa ggtgcggtcg gccagggcga
    12661 agctctcggc gccgtctctc atgcggcacc tcgctcggcg ccggcgggct cgtcctcgtc
    12721 gtggggcccg gcctcgtgga ggggcgtggc ctcgtggtcc aggtacgccg tcagcgcggt
    12781 gcggcggccg gccgtcgcga gatgctcggc gaggacggcg cgggcctggg acttgtcggc
    12841 ctcggggatg aagtcgtcga gtccgacggc cagtacgcgg ttgtcgtcgc tgggcttgag
    12901 cgaggcgtag tgctcgtcgc gcagcaggcc ccacacgatc gcgtcgtggt actgaccgtc
    12961 gaggtaacag tggtcccgca ggatgccctc gaccacgaac ggggtcttgg tcatcagccg
    13021 gatgatgccc ttgttgtagc cggcggtggt gacctgtacg cggtgcgcgt cgagctggtg
    13081 gaagaggtag tcgacgagca ggacgacggc ctccgcgccg tagccgcggc gccacaggtc
    13141 ggggctgccg atcgcgccac cgacggtgta gccgccgatc cggccgctgc gctggtagct
    13201 gacggcgccg atgcgctcgc cgtccttcgt acggatcacc aggttgtgga cccgccccga
    13261 gcggttggcc tgctcgatct cggccgcgcc caggagttcc cagtcgccgc tgagtacggc
    13321 cgccggcgag ccgggccgca gccaggaggc gatcgcggcc cagtcgtcgt cgccgggcca
    13381 ttccaaggtc accagtcgtc cctgcacggt gcgtctccct cctcagcctg tgtagcgggt
    13441 gagtacgagt acggcgttgt ggccgccgaa tccgaacgaa ttgctcagca ccacgtcgcc
    13501 gtcccagtcg cgggcgccct tgacgaccag atcgaggtcg ggttcctcgg ggtggtcgca
    13561 gttacggatc ggtgggatct tgcggtcccg cagcgagagc accgcggcgg cggcctcggc
    13621 agctccggag gcgccgagca tgtgcccggt catgctcttg acggcggtga tcggcgtacg
    13681 gcgcagatgg tcggggccga gtacctcgcg cagcgccgcg gcctcgatgc ggtcgttgag
    13741 cacggtgccg gtgccgtggg cgctgatctg cccgacgtcc tcgggggtgc ggcccgcgtc
    13801 ggcgagtgcg tagcgcatgg cgcggacggc tccggcgccg gtcgggtcgg gggcggtggc
    13861 gtggtgggcg tcggtggtcg cggcgtagcc ggccacctcg gcgaggatgg gtgcgccccg
    13921 gcgttcggcg tgcccggcct cctccagcgt caggacggtg gcgccgacag ccatcacgaa
    13981 gccgtcgcgg tcccggtcga agggccggct ggcgccttcg gggtcgtcgt tgcggcggga
    14041 gagggcctgg gcgttggcgg taccggccag gtcgacggcg gtgagcgcgt cgtcggcgcc
    14101 gccggccagg gcgatatcgg cccggccgtg gcggatcagt tcggccgcct cgccgatggc
    14161 caccgcgccg gtggcgcagg ccgccgacac cgcgcaactg gggccgccga tgccgtactt
    14221 gatggacagc aggctggccg ggtggtcgat ggcggtgagg accgagtggt acggggagac
    14281 ccgccgcgat ccctgccgct gcaggacgtc gtactgctgc tggatcgagt tggcggcgcc
    14341 gtagccggag ccgatcaccg cggcgaagcg gtacgggtcg atgccggccg gctcgtcgag
    14401 accggcggcg cgcagggcct gggtggcggc gaccaccgcg tactgcgtga agctgtcgct
    14461 gcgcctggct tcctgcggtg tgaggtagcc ggtcgtgtcg aagccggtga cctcgccgcc
    14521 gatgcggacc gggaggccgg aggtgtcgaa gcgggtgagg gtcttcacgc cgctgcggcc
    14581 ggcgagcaga gcggcccaga agtccgcggt ggtgtttccc acgggggaca ccacgccggt
    14641 gccggtgacg acaacgcgcc gccgttccgc acgtacctcc atgaaagcca cctcctagtt
    14701 ttctgccccg ttgtcacgct cggggcgtcc tcatgaccag aaacatgaca gccgagtcat
    14761 tggcttgtca acaggttgcg ccggagggag tcagtcagcg aaacctgtca tatgcgggat
    14821 gcaggcctcg taccagcgga aacgctctca gaggcgtgac tgactgagtc atgaaaattg
    14881 actatgaggc cggaggtcac agcggaaaca ggggccgggg cgacctgggc ggggcagccc
    14941 gggcggggcg gcggcgggcg gcggcgtagg cctcccggcc gccggccgac cccctggtag
    15001 ggccccggag tacatagaaa gtgacaggcg gcggggcggg aagtgcctac ctgcggatga
    15061 tccgaatgcc gcggccggac gggacgctgg tccgtacacg cagctccgac acatcacaag
    15121 acacatcaca aggacgaggg gaactcatga agggtattgc ggtaggtatt gttctggcga
    15181 tcgtcggcct gatcctgtgg ctgaccacaa aggaagtcga tacgggggtc gtctcgcttc
    15241 acaaggccgg gctggtcctg gcgatcgtcg gtggcgcgga agccttgttc gcgcttctgg
    15301 ggctcggaaa gaaggcgaaa aaataagcgc gcattgcgcg caataacggc atttgcggcg
    15361 ccatggtttt tggcaccccg gccttcagtc ccgcttttcg atgaggtccg tcagccgttc
    15421 ccgggcccgc tcggcgtgtc ggtacgcctg ggcccgccgg aacagctccg cggaataccg
    15481 gaagtgtccg gccgcccttt cccggtcccc cagccgctcg cacgccgccg cgatctccag
    15541 gagcgcggcg gctttctcat gaccgcggcc ggtgtcgggg agtgcggcca gctccacgcc
    15601 cagcgcgaaa acccggccgg ggtcgccggc cgcctccgca cagaccgcat ccgcggtcgt
    15661 cagccagagc gggaattccg gttcctgcgt caccgaggcg acgaccaggc cgcgctcgac
    15721 gatgctgcgg gccgccgccg tctcgccgcg gtgcagcaac agcagggcgt aatgcccgtt
    15781 gatcttctcc cagagcggga agccggcggt gggggtgacc cggcgcgcgc actcgcccag
    15841 cagcgcggcg gcgcgctcca tctcgccacg gtcgcgcaga tcgagcgccc ggtgcagatc
    15901 gatggcggcg cgcggcccgg ggagcacgcc ctccgccgag tgccggcagt ggtcggtatc
    15961 gggggcccac tccgggcagc cgctccaata ggcgcagcgg gtgagcacat cgaggacgag
    16021 cagtgagtgg aagcccgtgc cggggcgccg gtcggcgcat tcgagggagc cggtgagcgc
    16081 atagcgcagc ccgtcctgga cccggccggc cgactccagc agatcggcga gcgcgatcag
    16141 ggcgcgcagc cgggcctcgg cgtacggggc gggggtgagc gcgtccagca tccgcagcag
    16201 gacctcggcg ccctcgtcgg cgcggccgag agtgcccagt atttcggcaa tggcgagctg
    16261 cgcctcggta aatacgtcgt cctggcggcc ggccggatca atctcggcca gtgcgcggaa
    16321 ttcccgcagt gcgccctcgg cgtcgccgcc ctcccattgc cggcgggccg ccaccaatcg
    16381 tccgaccagg tcgagccggc ggacccggct ggtggtttcg acatgctcgg cggttctgga
    16441 tatttcgtcc acaccgaccc cgaggcgttg cgccaggatc ttcagtgccc gaccgctggg
    16501 aatgcgcttc ccgcgttcga cgagtgagat gtagctcgac gacatttcgg acccggcaag
    16561 gtcgtgctgt gtcattcccg cgctgacccg aagctctttg attctccgcc cggtgtccgc
    16621 cagctcaggc attcgacaaa ccctccggat ttcgaacagt ggatgactcc ggccgactgc
    16681 accaaatcgg cgcgagtcac aatgagtgct cggcacttta ccaagtagtc aagaagaagt
    16741 cgaccgatat tcggattcct tcaccggtct tcaccgggcc tgccaagatc atttcgaggg
    16801 gcgcgcacaa tgcggacaac gcctccggac ggagccgctg cccgcacccg aaaaccggct
    16861 gaccggtaca ccgaactatg tgctccggca ccgcgggtca acctttcgat gtagtaccgc
    16921 acggcgatgc ccgcgcccgg cgtgacgtgg tcggatgagg catcgacgct ccaccaccgc
    16981 cggactcagc ggaggcacca cccatgaccc agccccaacg acccgatctg cacaaggatg
    17041 tggcgccctc gcccgcgaca tcccgttcgg tgctggcctc ggacgccgaa cgcgaggaca
    17101 tggtcgaacg gctcagggaa gccaccgcgg aaggccggtt aaccctcgaa gagctggccg
    17161 agcgttccga ggcggcatat ctcgcgcgta cccgcgagga gttgcggtcc gtcggcgagg
    17221 atctgccgca tgtgactccc ccggagtcct cggcctccgc gaccggacag cgcagcttcc
    17281 gcgccgtatt cggcgatgtc acccaccaca gcccctccct ggagcacggc atcgaggcga
    17341 ccgcggtctt cggggatctg accctcgatc tgtgcgcctc cccggcaccg tcgaccggcg
    17401 aactgaccat cgaggcccgt gcgttcgtcg gcgatgtcca tctgctgctc ccggaaggcg
    17461 tccgggtcga gatgaactgc agcaaggtct tgggtgatct gcgcaatgtg acccgggaac
    17521 actccggccc ggaagccgtc accccgctca tccgcatcac cggctccgcc gtcttgggcg
    17581 acatcgtcgt cgcgcacccc aacagcgacc ggcgcacgta ctggcagaag tggctcgacg
    17641 agcgccgcgg ccgggcctga ccggaggaga agccgtgacg tcgattcagg ccctgccccg
    17701 ccccgagccg cccgcgcccg tcgccgacga gggccggata ggcccgcggg ccatggcgcg
    17761 gcacacgggc gcactggtcc gccgcaatct tctgcagatc cggcagaacc cggagtcgat
    17821 ggccgacgcg ctgctgatgc cgatcgtgct gacggtgctg ttcgtcttcg tcttcggcgg
    17881 ctcgatcggc gcgggcggtg accgcgcgca gtacaccgcc tttctggtgc cggggctgat
    17941 ggtgatcctc gggatgacca tcgcgatggc cgtcggcacc ggcgtcaacg acgacttccg
    18001 taccggcctg atggaccgct tccgcaccat gcccatcgcc cgttcctcgg tgctggtggc
    18061 caaggtcgtg gtggagaccg gccggatgct ggtcgcgatc gcggtgctgc tgatcgtcgc
    18121 cgcggtgctc ggcttcgact tcagcggacg ctggccgggc ctgctggccg cgatcggtct
    18181 gaccgccgtc ttcggcacct cgctgatctg gatattcatg ctgctggggc tgaccctgcg
    18241 caccgcacag gccatccagg cgctctccgt cgtcgtgctg accccgctgc aattcggctc
    18301 ctcgatcttc gtaccgccct cgaccatgcc ggactggctg caggccttca cccgtatcaa
    18361 cccgctgacg cacatggccg acgcggcccg cggactcgcc ctgggcgagg ggccggtggc
    18421 cggcccggtg ctctggacgc tcgtgtggtc gctgggcctc acggcggtca ccgccccgct
    18481 ggccatcgcc aagttccgcg ccaagacctg acaccgatcc gtacgggcgg agcgcatccc
    18541 ccgtcacgcc ctcggcgtgg ttccctccgt acgaagaaga cgtggcccgg ccccaccccg
    18601 gctccccccg ggccggtggg ggccgggcca cgcgaagcat cccccgtgga acacaatgcc
    18661 gcgccgtcgt ggcgggaact ccctcccgcc acgacggcgc ggcacgcacg gcgtacggct
    18721 agggcgcgtc ttttggagca gtccggatca gcccgcggcg tctggtgcac tgcactctcc
    18781 cccacgcctt aagggcgcgg gaggggcccc caccgctcgc tccgtctcgg ctctttgatt
    18841 catccttcgg atgccgagct gcatcgcaag gcggagcatc gccctcggac tgggtgtccg
    18901 tgggtgatgc gacaacgcgg cgagggggta cccccagcgt tagctggggg agtgccgtgc
    18961 ctgggggcac ctcccagcgc tagctggggg agcgtcgcgg gcccggggtg atccgaaaga
    19021 cgcgccctat gcgtcttccc gctccgggaa gtcccccgcc gagccgctca tccccggcgg
    19081 ggtgtcggcg agcgcgaccg ccacctccac cacggcgcag gtcccggcgg cgacctgccg
    19141 ccaggcggcc gtcagcgccg gctccagctg gtcggcgtcc gtcacccggc cgtagcccag
    19201 gccataagcg ctggtcaggc cctcggtgcc ggtcgggcgg gaggtggtga aggcgaaccg
    19261 cgagccggtt ccggagaccc ggtcgaggtt ggactgcagc cagccgtagc cgccgttgtc
    19321 caggacgacg tagaggacgg cggcgcccgc gtcggcgacg gtgggcagtt cgccgcggaa
    19381 gaggttgaag gctccgtcgc cgaccaccgc gaccaccggc cgcccggccg gctcggccag
    19441 tcgtacgccc accgcggcgg ccgcgccgaa gcccagcggc gtctgctcgc tgggcaccac
    19501 ggagccgcct tcggacccca gcgaccagtg cgggaagaag tacgaccaca tgtcctgcag
    19561 gccgttctcc tggacgagga cccggtccgc ggggacgaca cggtcgagtg cggccagcac
    19621 ccgggcgacc ggcacggctc cctcgggcgc gtgcttcacg gcctcctcgg cacggtccgc
    19681 ggcgcgcccg gccagcgcgg cccgcaccgt gcggacccgc tccggccagt cacgaggcgg
    19741 ccggcggtcg gccagcagtc ccgcccagcc gtccacgatc cgtccggcgt cacccaggac
    19801 atacgccccg ggtcgctcca tgaccagact ctcctcgccc aacacagcct gtacgaccgg
    19861 gagttgagcc gcatcctccg gccagccgaa ggtggcggtc tcctccagcc ggctgcccag
    19921 cgcgatgacc aggtcggcct cgcgccacag ggcgtccatc ggcgcgaccg tgtagaggcc
    19981 gctgacgccg cagtacaggg ggtggtcctc ggcgacggtg ccgcggccgg aggcggtgct
    20041 gaagatgccg gcgccgagct gctcggcgaa gtgctcgata cggcggccgt cgttgcggtg
    20101 ccgggcgccg ccgcccacca gcagcagcgg ccgctcggcg gcggcgatgc gctccgcggt
    20161 ggccgcgagc gcgtcctggt cgggggccgg ccgctggggg gcggccggcc gccagggccc
    20221 ggtgcgggtg accggctcgg ccgcgatctg ctcggcgagc tccaggtaga ccggccccgg
    20281 ggtgccgttg acggcgagcg cggcggcctt ctccagagca ccgggcagcc ggtcggcatg
    20341 gtcgacgcgg gccgcccact tcacgtacgg gcggatcgcg gtgagctggt ccagctcctg
    20401 gaaggcgccg gtgccgagcc ggtcgagccg ggtgccgtcg gcgatcagga tcagcggtgc
    20461 ggcggcggac cgcgcctcca ggacgccggt gagcgcattg gtcagcgccg ggcccttgcc
    20521 gatcacgcac accccgggcc ggccggcggc cagtgcgtaa ccggtggcca tgaacacggc
    20581 gttgcgctgg tcccggcaga gcaccacggt ggtgtcggac cgctccagct cgccgagcag
    20641 cgccatatcg tcgccgggca gcccgaacac cacctcgctg ccgaggtggt ggaggtggtc
    20701 ggcgatcgcg gcccaggcgg tggggtgggt gtaggtggtc atcggccggc tcccgggcgg
    20761 tgggcggcga cggccttgga gatcagtacg ggctcggcgc gcacctcccg gccgtcggag
    20821 atgtagttgg ccatccggcc gtacccgccg aacggggcgt tgccgtcgtc gatggacaac
    20881 agggtggtgt cgagggtgac ggtggtccgc cggcgcagcg cctcgacgag gccgggggcg
    20941 tggccgtaga cgctggagcc cagggcgcgt tcggtgaaca tgccggtggt gagggtcgcg
    21001 gcgagggcgt cctggtcgcg gtagccggcg acattgaaga tcggggcgaa gaattccggt
    21061 acgtgggtgc gcggggtgac gtcctcgccg acgacgacgg tggggtcgag ccggcgggtg
    21121 cggaagtcga catgcccgcc gtgcacgatg ccgccgcggt tgcgggcgag gaactgtgcg
    21181 ccgtcctcca gcgcgctctc gtagaagatc ggcccgtagt cggcgtccgg gtcggtgtac
    21241 gggccgtagc gcatcccctt cacctcgctg accagggcat cgacgaacgg ggcgagcagc
    21301 gactcatgga cgctgaacag gtccgggccc aggcagtcct ggccggtgtt caggacccgg
    21361 atggcgatcg cgtcgcgggc cgcctgctcg acatcggcgc cgggggcgac gacgaacggg
    21421 ttgacgccgg agccgaggaa gaggaacagc tgcccggggg agagctgggg gcggatctgt
    21481 tcggcgttgg cgtaggcgcc ggtgaagacc acgacgtcgg cggggaggac ctgctcctgc
    21541 aggaattccc gctggctggc gccggagagg gtgatgggca gaccgtgctg ctcggcgagc
    21601 agggtgtgca gccggcgcat ctggtccttg acgcggctgg aagggcggaa caccagccgg
    21661 tcggtgtaga gggcgggcac caggaggtag agggcgtagg agtagaggag gacgttcgac
    21721 ggcatgaagg cggccagccg ggggacccgg ccgggccggt gggcggccac ctcgtccagg
    21781 gccccgtcga gggtggcgac ggtcgactcg atctcgtagc gcgcggcgcg atgggtggag
    21841 atctcgcaca gcagctcgtg cacggtaccg gcgtcgttca ccagaaagtc ccggaccctg
    21901 tgcaaggccg ccgcacgtcg gctgtcgatg ctgtcctccg gctcggcggc cacggtcggc
    21961 catgcgggag cggagctcat atgtccctcc tcggggcgta gtccatggag ggtcagcgtc
    22021 agccaattgt catttattgt caagtaaagt cattgcactc gactggctca tatgacaagc
    22081 aacactgcac agggccgctc cacgccaccc gccgggtacc ctctcttccc tgtacacagc
    22141 catcgaggca ccctctcagc tgtcgcaacg cccgtgcgcc ggcaagggga atatctacct
    22201 ccgcaagtga caaaaaatga ctctgcggcc ggagggaagt cgtccacagg cacccccgca
    22261 cggacgtccg atgagtagac tcgccgccat cacgttccat ccgtccgcag ccgtcccacc
    22321 ccgtcaccgt ccgtccgccc aactcacctg cgagcgattt tcttgacgat tgagcagcct
    22381 gctttcggga agcgagtgcg ggaggtccgg cgcgctcagg gtctgtccca gggggatctc
    22441 gccggggacg atctctcccc cagctatgtc tcgctggtcg agaacggccg cagaatcccg
    22501 agcgccaaga tcgcccggtc catcgcggaa cggctcggca cgacggtcga ggcgctgtgc
    22561 gccaccgacc ggcccggcga ccgactgacc cagcgcctcg acctggtcgg ccagttggtg
    22621 gcggcccgcg ccagccagct ggccggtgac tggccggcgg cgctgcgcca gctggagtcc
    22681 gt
//
