LOCUS       NZ_CP084681            22220 bp    DNA     linear   CON 30-APR-2024
DEFINITION  Streptomyces inhibens strain NRRL30439 chromosome, complete genome.
ACCESSION   NZ_CP084681
VERSION     NZ_CP084681.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces inhibens
  ORGANISM  Streptomyces inhibens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Gillane,R., Talbo,G.H., Plan,M., Palfreyman,R.,
            Haber-Stuk,A.K., Power,J., Nielsen,L.K. and Marcellin,E.
  TITLE     Multi-omic characterisation of Streptomyces hygroscopicus NRRL
            30439: detailed assessment of its secondary metabolic potential
  JOURNAL   Mol Omics 18 (3), 226-236 (2022)
   PUBMED   34989730
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Palfreyman,R. and Marcellin,E.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2021) EMS, Australian Institute for Bioengineering
            and Nanotechnology, Cnr College Rd & Cooper Rd, Brisbane, Queensland
            4103, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. APRIL-2018
            Assembly Name                     :: AIBN_shyg
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 239.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022221585.1-RS_2024_04_30
            Annotation Date                   :: 04/30/2024 04:58:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,775
            CDSs (total)                      :: 8,682
            Genes (coding)                    :: 8,305
            CDSs (with protein)               :: 8,305
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 377
            CDSs (without protein)            :: 377
            Pseudo Genes (ambiguous residues) :: 0 of 377
            Pseudo Genes (frameshifted)       :: 158 of 377
            Pseudo Genes (incomplete)         :: 310 of 377
            Pseudo Genes (internal stop)      :: 38 of 377
            Pseudo Genes (multiple problems)  :: 116 of 377
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:32:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1717199
            Orig. end                         :: 1739419
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084681.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Australian Institute for
            Bioengineering and Nanotechnology, Building 75,Cnr College Rd &
            Cooper Rd, Brisbane City QLD 4072.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22220
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="14"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..22220
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22220
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12220](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12220
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    851..865
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.37"
                     /tool="antismash"
     gene            complement(1120..1293)
                     /locus_tag="KI385_RS07985"
                     /old_locus_tag="KI385_08035"
     CDS             complement(1120..1293)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576014.1"
                     /locus_tag="KI385_RS07985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08035"
                     /product="CsbD family protein"
                     /protein_id="WP_238571515.1"
                     /transl_table=11
                     /translation="MGIRKKSRNIGEMAEGKAKETTGKVLGNESLEKKGKMEKAKGKVK
                     QAVERGKDTLRH"
     gene            complement(1344..1751)
                     /locus_tag="KI385_RS07990"
                     /old_locus_tag="KI385_08040"
     CDS             complement(1344..1751)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090738.1"
                     /locus_tag="KI385_RS07990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08040"
                     /product="gas vesicle protein K"
                     /protein_id="WP_238571516.1"
                     /transl_table=11
                     /translation="MAGEVRGPANHFDDVAEAAGRAFRLLPAAPQDLQPPRGTAAGSGT
                     HRVTTDPDTVERDLIKLVLTLVELLRQLMERQALHRVDAGDLTEEQEERLGATLMILHE
                     RMVELCARYDLSMQDLNLDLGPLGTLLPPSE"
     gene            complement(1741..1986)
                     /locus_tag="KI385_RS07995"
                     /old_locus_tag="KI385_08045"
     CDS             complement(1741..1986)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607243.1"
                     /locus_tag="KI385_RS07995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08045"
                     /product="gas vesicle protein"
                     /protein_id="WP_238571517.1"
                     /transl_table=11
                     /translation="MRAAGGPPTAAQEPLPDRQIALIDLLDRLLTGGAVLTGDIVLSIA
                     DIDLVRVSLNALIVSISEQNLSPWPADPPLGDGHGR"
     gene            complement(1983..2798)
                     /locus_tag="KI385_RS08000"
                     /old_locus_tag="KI385_08050"
     CDS             complement(1983..2798)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090740.1"
                     /locus_tag="KI385_RS08000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08050"
                     /product="GvpL/GvpF family gas vesicle protein"
                     /protein_id="WP_238571518.1"
                     /transl_table=11
                     /translation="MTEVITYAYAVAQDADGSLEEELSGLPGVADAPVHLVRTGHRGDV
                     VVAVSPVPEQDFQEAALRAHLEDLDWLELVARAHHRVIEALAARTTVLPLRLATVYLDD
                     ERVRQMLDARLEAFAERLSELAAHVEWGVKIYVEASAAAESPAAASAEPDLSPGRAYLS
                     HRRAQRHAREDAYRTAEQAARHVEDAARGVAVDRVQHRTQQGELARGPGENVVNDAYLV
                     PLEHAERLRTDVLRAAEGFTGVRVEVTGPWAPYSFATPAEAEPLKGATP"
     gene            complement(2795..3304)
                     /locus_tag="KI385_RS08005"
                     /old_locus_tag="KI385_08055"
     CDS             complement(2795..3304)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607245.1"
                     /locus_tag="KI385_RS08005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08055"
                     /product="gas vesicle protein"
                     /protein_id="WP_238571519.1"
                     /transl_table=11
                     /translation="MSEPVARRLGDLPSRSAQYGQGSSANLADILERVLDKGIVIAGDI
                     QINLLDIELLTIKLRLLVASVDKAKEMGIDWWEHDPALSSRASDGYSSLAEENKRLRAE
                     IEALRERGELPRAEDEEEEEEEEEEEEEDEEESRPAAPRRAPRTSRTKRAQPSPRSKSS
                     KKRDEP"
     gene            complement(3381..3632)
                     /locus_tag="KI385_RS08010"
                     /old_locus_tag="KI385_08060"
     CDS             complement(3381..3632)
                     /NRPS_PKS="Domain: PKS_Docking_Cterm (37-81). E-value:
                     0.00053. Score: 12.8. Matches aSDomain:
                     nrpspksdomains_KI385_RS08010_PKS_Docking_Cterm.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607246.1"
                     /locus_tag="KI385_RS08010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08060"
                     /product="gas vesicle protein GvpG"
                     /protein_id="WP_238571520.1"
                     /transl_table=11
                     /translation="MGLLTQLGTFPLAPVRGVAWVMERVLEAAENEYYDPEPVERELAE
                     LERALLAGDIDEETFDRREDELLDRLDEIRAHQQGTDT"
     aSDomain        complement(3390..3521)
                     /aSDomain="PKS_Docking_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KI385_RS08010_PKS_Docking_Cterm.
                     1"
                     /evalue="5.30E-04"
                     /label="KI385_RS08010_PKS_Docking_Cterm.1"
                     /locus_tag="KI385_RS08010"
                     /protein_end="81"
                     /protein_start="37"
                     /score="12.8"
                     /tool="antismash"
                     /translation="PVERELAELERALLAGDIDEETFDRREDELLDRLDEIRAHQQGT"
     gene            complement(3642..4355)
                     /locus_tag="KI385_RS08015"
                     /old_locus_tag="KI385_08065"
     CDS             complement(3642..4355)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090743.1"
                     /locus_tag="KI385_RS08015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08065"
                     /product="GvpL/GvpF family gas vesicle protein"
                     /protein_id="WP_238571521.1"
                     /transl_table=11
                     /translation="MAVYVYSIVATDHPQRLDGLDGVGDPPTALRTVHTKKLSAVVSDA
                     PEELRPKRRDLGAHQAVQERLMADGTVLPLQFGFTTTGDDAVREVLEDRTDELTERLQA
                     LKGCAEYHLKAGQDEDAMLRQILTESDEARRLNEDIRSGNAGPDLPLALGELVAKEVEA
                     RQDRLAAAVVDALREFAREESVSKPTGNDFVSVSFLVDQKNEKRLRAAEQELAEELGED
                     FDLRLRGPLPAYSFV"
     gene            complement(4359..4823)
                     /locus_tag="KI385_RS08020"
                     /old_locus_tag="KI385_08070"
     CDS             complement(4359..4823)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607248.1"
                     /locus_tag="KI385_RS08020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08070"
                     /product="gas vesicle structural protein GvpA"
                     /protein_id="WP_238571522.1"
                     /transl_table=11
                     /translation="MTVVPQSGGTVARGGGGGSGNLYDILDLILDRGLVIDVFVRVSLV
                     GIEILKIDARIVVASVDTYLRFAEACNRLDLEEGRKAPSQLTDIVGEVTEGGSHGKAKG
                     ALSGAAEAVTEALKGGHEDDEDDEEPAERRKEHAEKRERPARRPVRHRKE"
     gene            complement(4913..5314)
                     /locus_tag="KI385_RS08025"
                     /old_locus_tag="KI385_08075"
     CDS             complement(4913..5314)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379333.1"
                     /locus_tag="KI385_RS08025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08075"
                     /product="gas vesicle protein"
                     /protein_id="WP_238571523.1"
                     /transl_table=11
                     /translation="MAAGEEDETERVRRPSGKKTAKKTARTTSSARADSRKGETEPERV
                     AGRVSAPRAMRNAAEQLQQLLGRAPESVSAVKPTEDGWQADVEVLELERVPSTTSVMAT
                     YRVVLDKEGELVAYERIRRYTRSQIDRGT"
     gene            5514..7628
                     /locus_tag="KI385_RS08030"
                     /old_locus_tag="KI385_08080"
     CDS             5514..7628
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090746.1"
                     /locus_tag="KI385_RS08030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08080"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_238571524.1"
                     /transl_table=11
                     /translation="MSDGAGSDPVDRALLRAMRETGASAGGLYVLAADEPVLRLTVMSG
                     VPAPFLEPWSRVALAAPIPVAVATRQQRLVWAAGHQQLTRDFPRTAVAVPYDFALAAAP
                     ISDGTGRRGALLLLWPAGHPPQLSADEAEAVRAGCRRLAALLATSPLPNGEPAEVPRVL
                     SPPPVRTVGRVEALAAVDYVERLPGGCCALDLDGCITLVTTGAEELLGEEDTRLIGSHP
                     WEVLPWLRDPVFEDRYRAAVLSRRPTSFTALRPPKQWLTFRLFPDARGLSVWITPSGED
                     HDPVASYPAETVPVRAGQIYHVLHLSAALTEAVGAADVVDLVADQIVPAFGAQGMLMYA
                     AEAGRLRTIGHRGYPAEAVAAFEGVALSAANSPAVHALATGEPSFFSSPEELERVYPGL
                     PHLTGKAARAVLPLIVSGRPVGCCILGYTRPRTFSVEERQVLTSLAGLIAQALDRARLY
                     DTKQQLAHDLQAGLLPHSLPPVPGFAVAARYLPSTRGMDIGGDFYDLIRLGKDSVAAVI
                     GDVQGHNAAAAALMGQARTAVHAYATAGASPAEVLARTNRLLTDLDPDLFTSCLYVHID
                     LLTRRACLASAGHPPPLLRHPDGHTTVLDVPPGLLLGIEPDARYDATEIALPPESVLVL
                     YTDGLVEAPGVDLDRAVADLAGRLDDAPPQGPDGLADALLQNRQDEADRQDDVALMLLA
                     SRPIASTAAA"
     gene            complement(7642..9273)
                     /locus_tag="KI385_RS08035"
                     /old_locus_tag="KI385_08085"
     CDS             complement(7642..9273)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014050127.1"
                     /locus_tag="KI385_RS08035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08085"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_238571525.1"
                     /sec_met_domain="DAO (E-value: 5.2e-07, bitscore: 28.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDAVVIGAGPNGLVAANLLADAGWTVEVLEEQNEPGGAVRSDRG
                     VHPDYVNDLFSSFYPLAAASPVLSALRLYEQGLVWSHAPRVLAHPLTDGRCALLERDTA
                     DTAAGLEAFGVGDGAAWQALCGVWDRVGSDLVDAMLTPFPPLRATARLAARLRGAGGLR
                     LARTMLLPVRRLGDEEFRGEAGRLLLAGNALHADLAPEAAGSGGFGWLMSMLGQTCGFP
                     VPAGGAQSLTAALVRRLQRSGGVLRCGERVVGIVVRSGRAVAVRTAIGETVPARRAVLA
                     DVSVPALYGRLVDSRYLPGPLLADLRRFQWDFATFKVDWALDGPVPWTAEGAATAGIVH
                     LADGMDELTRFAAQIAMGQVPDRPFVLFGQMTTADATRSPAGTESAWAYTHVPHGIRGD
                     AGEDGITGAWDPREQEMMANRVEAQVERFAPGFRSGIRARRILAPPTLEAMNANLHGGA
                     LNGGTTAVHQQLVLRPLPGLGRPETPVEGLYLASAGAHPGGGVHGAPGANAARAALRRR
                     APSGLLSRTQRALATPFVNARPAKAG"
     gene            complement(9328..9783)
                     /locus_tag="KI385_RS08040"
                     /old_locus_tag="KI385_08090"
     CDS             complement(9328..9783)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (3-141). E-value:
                     4.1e-10. Score: 32.2. Matches aSDomain:
                     nrpspksdomains_KI385_RS08040_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090748.1"
                     /locus_tag="KI385_RS08040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08090"
                     /product="SRPBCC family protein"
                     /protein_id="WP_238571526.1"
                     /transl_table=11
                     /translation="MAVRHQLIKRSPEALWAVLADGSRYADWVVGTAHSRPVDGNWPEV
                     GSAIEYTVRLGPWDLIGHTVVRHSSPPRELELEVDSGRLGTVRIAVEVRSWGEDSLVIV
                     DEHPLRGPAGRLHNAGLEFLLQLRHRSMLSRLAAVAENAPHGAHTGP"
     aSDomain        complement(9361..9774)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KI385_RS08040_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="4.10E-10"
                     /label="KI385_RS08040_Polyketide_cyc2.1"
                     /locus_tag="KI385_RS08040"
                     /protein_end="141"
                     /protein_start="3"
                     /score="32.2"
                     /tool="antismash"
                     /translation="RHQLIKRSPEALWAVLADGSRYADWVVGTAHSRPVDGNWPEVGSA
                     IEYTVRLGPWDLIGHTVVRHSSPPRELELEVDSGRLGTVRIAVEVRSWGEDSLVIVDEH
                     PLRGPAGRLHNAGLEFLLQLRHRSMLSRLAAVAE"
     gene            10001..12220
                     /locus_tag="KI385_RS08045"
                     /old_locus_tag="KI385_08095"
     CDS             10001..12220
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.4"
                     /locus_tag="KI385_RS08045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08095"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_238571527.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.7e-44, bitscore:
                     151.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGSGDAYVVAADLVRHRTTAADGSPGWGHGLVWSFIDVRRRSHA
                     AESWVDRGAVDAFRAAAAGAMDARVRAALLEALAAGLPVAPDRLLPDPVRVGPGPFDIG
                     FGAAGTLYEEQDGGRYGLTLRGERAHCDLVFSPVPGPASAGTTGDATYAPRYAVAGRVG
                     APGTEGTIDVSGEGWIETGSGEDRCKTGRDEERCKTGRGDGRYPAGPGGGPLSDELPAG
                     TRDIGRQRLTVLLDDGWRVTAESVDHVDVPSRAVLAHQDLLTAYAPDGRALPADDARCR
                     SAAPWTSLATLNTYPTTWTVTSEQLRLRLDVTAHFPGQEVRTMLAGHGFLCAAARVAGT
                     RAGRAVTGWALVSAVPAQRIGDLEEYLGRLHKVTRREVRRLYPDRPSSATTRSLLGGTG
                     ASLDGFTDTAVHQTLVRPVRHLTDPGGRGWRTYVCCAAIELVGVRADPYTPLLAAVEVI
                     HSANLAIDDVQDGSLHRRGVSAVHRVFGVPATVNAATAAYFALDRVIDDLVPADDGLKL
                     AVCRTYLRTLRAAHGGQALDLAGHTEEMDAAVATGDPRPLLRRLRAAHRFKTGVPARGF
                     AELGALVARADGAQRAAIGAYFEAVGTAYQISDDVLDLLGATAPQPSGSSRKHTGEDLR
                     SGTVTMPLAHCVALLPADRVRLLWKAVRDGGADADTVHGVATAIARSGAVQACQREARA
                     LVDDAWRTLAPLLPASLTKILVRALGTYAALREPEPPAAPAPRPK"
     gene            complement(12293..12913)
                     /locus_tag="KI385_RS08050"
                     /old_locus_tag="KI385_08100"
     CDS             complement(12293..12913)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607037.1"
                     /locus_tag="KI385_RS08050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08100"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_238571528.1"
                     /transl_table=11
                     /translation="MIPALLGPARSKRTAADDEQVTGLALAARDGDPDAVERFVRATHR
                     DVWRFVAHLSGDMNGADDLAQETFLRALTSLPRFAGRSCARTWLLSIARRVVIDRYRSA
                     AARPRIADINDWQTVAEHRQPSGLPGFEDGLALSELLDALDRERREAFVLTQLVGLPYA
                     DAAAVVGCPVGTVRSRVARARADLTEWLRSAETSARVPRIVAA"
     gene            complement(13217..14029)
                     /locus_tag="KI385_RS08055"
                     /old_locus_tag="KI385_08105"
     CDS             complement(13217..14029)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062969.1"
                     /locus_tag="KI385_RS08055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08105"
                     /product="PE-PGRS family protein"
                     /protein_id="WP_238571529.1"
                     /transl_table=11
                     /translation="MTTGPASRAARAAIFATVCVMTTVLGHGLMSAQPVPWWAVIAAFG
                     ATGAAAWWLTGRERGAVVVTGCTVFAQLGLHSLFGFSQQSAGGTGIAASSDGQWAERLF
                     CNGSGVDPALRASALRLLRQAGLDPLATQTPPPTPMSGMRGMRGMAEMVTMPGMGHTGA
                     MAGDMGHMGHLQMTHSGHGTLGMFLAHALAAFVCGIWLWRGEAAVFQLARSLAAALFAP
                     LLLVLRTLGRTGGKLPVRRVVSSHVLCLRGALLQYAVSRRGPPRLSVC"
     gene            14301..15731
                     /locus_tag="KI385_RS08060"
                     /old_locus_tag="KI385_08110"
     CDS             14301..15731
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091463.1"
                     /locus_tag="KI385_RS08060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08110"
                     /product="PepSY domain-containing protein"
                     /protein_id="WP_238577607.1"
                     /transl_table=11
                     /translation="MAGSTEQRPARRAGWAALRPLVLRLHFYAGVLVAPFLLVAAVTGL
                     LYACSFQAEKVVYAHELSVPVGTRTLPLSQQVADARQAHPEGKLAAVRPAPQPGDTTRV
                     LLSDVPGVPAGHQLAVFVDPYTGSVRGALETSGSTGALPLRTWLDSLHGNLHLGETGRL
                     YSELAASWLWVVTGGGLALWIGRKRTNRKLRALALPDRRATGRRRTLSWHGAVGVWAAA
                     GLFFLSATGLTWSAYAGANIDDLRKSLGQATPTVSTAVAEGHGQHSGAAGMAGMPDMPG
                     MEGMHHDGSAGSAPSDVGINQVLKAARAQGLSDPVEIVLPTEPGTTYLVKQVRRSWPEK
                     QDSVAVDPAGGKVTDVLRFADYPVLAKLTRYGIDLHTGILFGLANQIALAALALALIFL
                     IAWGYRMWWQRRPTRERALSFGRPIPRGAWRQVPLPVLIPLVPAVGAVGWAVPLLGITL
                     VAFLAVDLALGVIARRRA"
     gene            15953..16975
                     /locus_tag="KI385_RS08065"
                     /old_locus_tag="KI385_08115"
     CDS             15953..16975
                     /NRPS_PKS="Domain: PKS_ER (20-265). E-value: 8.1e-12.
                     Score: 36.8. Matches aSDomain:
                     nrpspksdomains_KI385_RS08065_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433259.1"
                     /locus_tag="KI385_RS08065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08115"
                     /product="alcohol dehydrogenase"
                     /protein_id="WP_238571530.1"
                     /sec_met_domain="ADH_N (E-value: 1.4e-29, bitscore: 101.2,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.6e-20, bitscore:
                     71.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVYRVAQVDTAGGPFEIVEREVPQPGPGHVRIAVDACGICHSDA
                     FFVNAAFPGVRFPMVPGHEIAGRIEEVGEGTYSGWQVGDRVAVGWFGGSCGHCTPCRQG
                     DFMVCENLKVPGWAYDGGYAEAVIAPVDALARIPDALAAPDAGPLACAGVTTYNGLRRS
                     SARSGDLVAVLGIGGLGHLGVQYAAAMGFETVAIARGAGKADFAKQLGAHHYVDSTADT
                     PVGDALQSLGGAKVVLATAANSEAITATVDGLTHRGELVVIGADPDPLGISPTQLLMSG
                     KIVRGHPSGTAQDVQDTMAFSALHGIRPMTEIMPLDQAPDAYQKMLSGTARFRMVLTNR
                     "
     aSDomain        16013..16747
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KI385_RS08065_PKS_ER.1"
                     /evalue="8.10E-12"
                     /label="KI385_RS08065_PKS_ER.1"
                     /locus_tag="KI385_RS08065"
                     /protein_end="265"
                     /protein_start="20"
                     /score="36.8"
                     /tool="antismash"
                     /translation="REVPQPGPGHVRIAVDACGICHSDAFFVNAAFPGVRFPMVPGHEI
                     AGRIEEVGEGTYSGWQVGDRVAVGWFGGSCGHCTPCRQGDFMVCENLKVPGWAYDGGYA
                     EAVIAPVDALARIPDALAAPDAGPLACAGVTTYNGLRRSSARSGDLVAVLGIGGLGHLG
                     VQYAAAMGFETVAIARGAGKADFAKQLGAHHYVDSTADTPVGDALQSLGGAKVVLATAA
                     NSEAITATVDGLTHRGELVVIGA"
     gene            17146..19233
                     /locus_tag="KI385_RS08070"
                     /old_locus_tag="KI385_08120"
     CDS             17146..19233
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601741.1"
                     /locus_tag="KI385_RS08070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08120"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_238571531.1"
                     /transl_table=11
                     /translation="MSAADGRPADAGEPEDRPPRPSGLMDLLGVAAVLLDAEGRIVLWS
                     PQAEDLYGYTADEALGQYAAPLLVHEEHWDLVMKKFADVMETGQSWGGSFPVRHKDGTA
                     RLVELRNMRLLDDRGDFYALGLATDSPTLREVERDVALSTRLIAQSPIGVAILDTDLRY
                     VAVNPALERMHGIPAKDHLGRHYREIMTSAKFAVPEAAMQQVLETGTPLVDHSTIVGRT
                     PADPDHKHAWSISLYRLEDPQGRVLGVADLVVDVTDRYQAAVEAAEARRRLALIADGSA
                     RIGTTLEVGQTARELAEVTVPELADVVTVDVLDSVLDEHRPARGDGPAVFRALAVRAAY
                     PTEAAQAADPPGEIAAYDTDRLATQCVRTGRPILISHADDSDLARIARDDHAASLLARA
                     GVHSYMLAPLTARGHILGCLGLSRARNPLPFDEDDLALAGELASRAAVCIENARSHQSV
                     RNAAETLQRSLLPDHPPHLPGLRIASRYRPALATYEIGGDWYDVLPLNDDKTALVVGDV
                     MGSGIDAAATMGRLRTATSAFADLDLDPAQVLQHLDKITSGLEHYIATCVYAVYDPHRA
                     ECHIATAGHLPPALVRRGKRPELLDLPTGTPLGVGGVPFETTTFGLGPGDKLVLYTDGL
                     VETRHHPIDERLETLRQLLDAPDRSLEETCDRLLRELRRPDDPDDVALLIARTQPFPPG
                     S"
     gene            19360..19515
                     /locus_tag="KI385_RS08075"
                     /old_locus_tag="KI385_08125"
     CDS             19360..19515
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146516.1"
                     /locus_tag="KI385_RS08075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08125"
                     /product="DUF6131 family protein"
                     /protein_id="WP_238571532.1"
                     /transl_table=11
                     /translation="MIVLGIILLVIGFLTGVGILWTIGIVLAVLGAILWVLGSLGHAVG
                     GRRHYW"
     misc_feature    complement(19361..19376)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            complement(19642..20235)
                     /locus_tag="KI385_RS08080"
                     /old_locus_tag="KI385_08130"
     CDS             complement(19642..20235)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638634.1"
                     /locus_tag="KI385_RS08080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08130"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_238577608.1"
                     /transl_table=11
                     /translation="MAQRKRQLVSNELAEAALQLLALKGFDAVTIDEIATTAGVSKRTF
                     FRYFASKEDVVVQFLADMGTGIHAELAARPIEERPSVALRHAVWVSIAACGDHSDRALR
                     VVQLILRTPALYARFLERQAQWRDDLTGELARRLGLDAHTDLYSQLAAGMALTAFDAVL
                     QRWSNSDGAEDPAELTDRAFAVIAPALDAVRNGR"
     misc_feature    20204..20224
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.65"
                     /tool="antismash"
     gene            20340..21263
                     /locus_tag="KI385_RS08085"
                     /old_locus_tag="KI385_08135"
     CDS             20340..21263
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (18-109). E-value: 7.5e-10.
                     Score: 30.9. Matches aSDomain:
                     nrpspksdomains_KI385_RS08085_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105641.1"
                     /locus_tag="KI385_RS08085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_08135"
                     /product="oxidoreductase"
                     /protein_id="WP_238571533.1"
                     /transl_table=11
                     /translation="MTQQRHWTAEQIPDQTERVFVVTGANSGLGLATTRALVRRGGHVI
                     LAVRDRTKGHRAVAEITAEQPDASLEVRHLDLADLDSVRAFAHQLHTDHPRLDVLINNA
                     GVMAPPRSLSAQGHEAQFACNHLGHFALTGLLLDLLAVGHNPRVVTVSSVNHRQGRIHF
                     EDLTGERGYKPMAFYNQSKFANAVFGRELHRRLTEAGSPVRSLLAHPGYTATNLQMSAP
                     VGLWRVIFGHIGNPLFAQPPARGALPQLYAATEPNVEGGAFIGPDGPAELRGGPKRVQL
                     SPAAADRETGRRLWELSEQLTDVRFV"
     aSDomain        20394..20666
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KI385_RS08085_PKS_KR.1"
                     /evalue="7.50E-10"
                     /label="KI385_RS08085_PKS_KR.1"
                     /locus_tag="KI385_RS08085"
                     /protein_end="109"
                     /protein_start="18"
                     /score="30.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VFVVTGANSGLGLATTRALVRRGGHVILAVRDRTKGHRAVAEITA
                     EQPDASLEVRHLDLADLDSVRAFAHQLHTDHPRLDVLINNAGVMAP"
     CDS_motif       20397..20480
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KI385_RS08085_0001"
                     /evalue="2.60E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="KI385_RS08085"
                     /protein_end="47"
                     /protein_start="19"
                     /score="16.9"
                     /tool="antismash"
                     /translation="FVVTGANSGLGLATTRALVRRGGHVILA"
ORIGIN
        1 ggtgatcgcg gcgaggtgcg cctccacatc gtctccgcag agcacgctct ccgcgacgcg
       61 atcgggggtg atcagttcgg cggcctgctc gaagtggcgg ggcgtgggga ggatctgcgg
      121 cagctcgccg ggcagctgtt cggtggccca gagccggtgc gcggtccgta gcgcatcctc
      181 gcggtcgctg gaccagcaca ccttcagtcc acccatggcc ggcttcgaac cgccgccact
      241 gcgccggaac cgctccacgg cctcggcgtc gggctccatg gtgaggaagc cgtccccgac
      301 gcggccggcc agctcggtcg cggccgggcc gaacccggac acgtcgatgg gcaccggctc
      361 gtcgggaagg gtgtacaggc gcgcgttctc gaccgtgtag tgcttcccgt ggtggctcac
      421 ctcgtcgccc gcgaagagct ggcgcatcac ctgaacggcc tcttccagca tctccagtcg
      481 caccgccgcc cgcggccagg gatcgcccag gacgtgttcg ttcagcgcct cgccggttcc
      541 caccccgagc cggaagcggc cctgggtctg gacggcggcg gtggcggccg cctgggcggt
      601 gacggcgggg tggagccgca tgatcgggca ggtcaccgcg gtctcgatgg gcagcgaggt
      661 ggcctcggac agtgcgccga tcaccgacca tacgaagggg ctctggccct gtgcgtcgtt
      721 ccacggatgg aagtggtcgg agatccacag cgaggtgaat ccggcctgct cggccatccg
      781 tgcctgctcg acgagcgcgg ccgggccgtg ctcctcgcag gacaggaagt agccgtactc
      841 agccattgat cctccacatg tgtgccgggg gtcggcggcg ctaccgctgc ggctctcctc
      901 gtccgggcag gcgccgggct gagctgtcgt ggtgcgcagg gcctcttcga ccgtacggat
      961 cctcgccacg ctccgcaccc ggagcacggg gccggtccgc gacgtccgcc ggcggtgccg
     1021 ggtccaggcc gatcggcggg cggcacgagc agccgcatcg cgagggcggc ggcccccgcc
     1081 gtcgcgggga gtgcgacggc gggggccggg cggtggcggt cagtgcctga gcgtgtcctt
     1141 gccccgttcc actgcctgct tcaccttgcc cttggccttc tccatctttc ccttcttctc
     1201 caggctttcg ttgccgagga ccttcccggt ggtttccttt gcctttcctt cggccatttc
     1261 gccgatgttc ctgctcttct ttctgatgcc catgtcgtgc tccttcaggg ccttcggccg
     1321 agcaagcggg gctcggtcgg ctgtcattcg gacggtggca gcaatgtccc gagaggtccg
     1381 agatcgagat tgaggtcttg catggaaagg tcgtatcggg cacagagctc caccatgcgc
     1441 tcgtgcagaa tcatgagtgt ggcgcccagc cgctcctcct gttcctcggt gagatctccg
     1501 gcgtcgaccc ggtgcagcgc ctggcgttcc atgagctgcc gcagcagttc gacgagggtg
     1561 agaacgagct tgatcaggtc ccgttccacc gtgtcggggt cggtggtgac ccggtgtgtg
     1621 ccgctccccg ccgccgtgcc gcgcggcggc tggaggtcct gcggtgccgc gggcagcagc
     1681 cggaaggcgc ggccggccgc ttcggcgacg tcgtcgaagt ggttggcggg ccctcggact
     1741 tcacctgcca tgaccatctc ccaggggtgg gtcggcaggc cacggggaga ggttctgttc
     1801 gctgatggag acgatcagcg cgttcagcga gacgcgtacg aggtcgatat cggcgatcga
     1861 cagcacgatg tcaccggtga ggaccgcacc tccggtcagc agccggtcca gcaggtcgat
     1921 cagcgcgatc tgccggtccg gcagcggctc ttgcgccgcg gtcggcggcc cgcccgccgc
     1981 cctcacggcg tggccccctt caacggttcg gcttcggcgg gggtggcgaa cgagtagggg
     2041 gcccagggcc cggtgacctc gacgcgtacc ccggtaaatc cctcggccgc ccgcagcacg
     2101 tccgtacgca accgttcggc gtgctccagc ggtacgaggt aggcgtcgtt gacgacgttc
     2161 tcccccggcc cgcgggcgag ttcgccctgc tgcgtccggt gctggacccg gtcgaccgcc
     2221 acgccgcggg ccgcgtcctc gacgtgccgg gccgcctgtt cggctgtgcg gtaggcgtcc
     2281 tcgcgggcat ggcgctgcgc cctgcggtgg ctgaggtagg cgcgtccggg gctcaggtcc
     2341 ggctccgccg acgccgccgc cgggctctcg gcggccgcgg acgcctcgac gtagatcttg
     2401 acgccccact ccacatgcgc ggccagctcg gacagccgct cggcgaacgc ctccagacgg
     2461 gcgtcgagca tctgccgcac ccgctcgtcg tcgaggtaga cggtggccag ccggagtggc
     2521 aggacggtgg tgcgcgcggc cagcgcctcg atcacccggt gatgggcgcg ggcgaccaac
     2581 tccagccagt ccaggtcttc gaggtgtgcg cgcagtgcgg cctcctggaa gtcctgctcg
     2641 ggcaccgggc tgaccgcgac gaccacgtcc ccgcggtgtc ctgtgcgcac cagatgcacc
     2701 ggcgcatccg ccacgccggg gagcccggac agctcctcct ccagcgatcc gtcggcgtcc
     2761 tgcgccacgg cgtaggcata ggtgatgacc tcggtcatgg ctcatcccgc ttcttgctgc
     2821 tcttgctgcg ggggctcggc tgggcccgtt tggtgcggga ggtgcgggga gcacgccggg
     2881 gtgcggccgg gcggctctcc tcctcgtcct cttcctcttc ctcttcctct tcctcttcct
     2941 cttcctcgtc ctcggcccgg ggcagttcac cgcgctcgcg cagggcctcg atctcggcac
     3001 gcagccgctt gttctcctcg gcgagcgagc tgtagccgtc ggacgcgcgg gacgacagag
     3061 cggggtcgtg ctcccaccag tcgatgccca tctccttcgc cttgtccacg gaggcgacca
     3121 gcaggcgcag tttgatggtg agcagttcga tgtccaggag gttgatctgg atatcgccgg
     3181 cgatgacgat gcctttgtcc aggacccgct ccaggatgtc ggcgagattg gccgatgagc
     3241 cctggccgta ctgggcggac ctggacggga ggtcgccaag tctcctggca acgggttccg
     3301 acacggccac tacctcgctt ccctggtaac ccggcgtccg gacgggagcg cggggcgccc
     3361 tccggattca gctgtcgcga tcaggtgtcg gtgccctgtt gatgggccct gatctcgtcc
     3421 agccggtcca gcagttcgtc ctcgcgccgg tcgaaggttt cctcgtcgat gtctcccgcc
     3481 aggagcgctc gctccagctc ggcgagttcc cgctcgacgg gttcggggtc gtagtactcg
     3541 ttctccgcgg cctccaacac gcgctccatg acccaggcca cgccgcgcac cggcgccagc
     3601 ggaaaggtgc cgagctgagt cagcaggccc atgacgtctc cctagacgaa gctgtaggcg
     3661 ggcagtggcc cgcgcagccg cagatcgaag tcctcgccca gctcctcggc gagctcctgt
     3721 tcggcggcgc ggaggcgctt ttcgttcttc tggtccacca ggaaggacac gctcacgaag
     3781 tcgttgccgg tcggcttcga cacgctctcc tcacgggcga actcgcgcag tgcgtcgacg
     3841 accgccgcgg cgagccggtc ctggcgcgcc tctacttcct tcgcgaccag ttcaccgagc
     3901 gcgagcggca gatccgggcc ggcgttgccg cttctgatgt cctcgttgag ccggcgcgcc
     3961 tcgtcggact ccgtaaggat ctggcgcagc atcgcgtcct cgtcctgacc ggccttcagg
     4021 tggtattcgg cgcagccctt cagcgcctgc aaccgttcgg tgagttcgtc cgtacggtcc
     4081 tccagcacct cgcgtacggc gtcgtcgccc gtagtggtga aaccgaactg cagcggcagg
     4141 accgtgccgt cggccatcag ccgctcctgg acggcctggt gggcgccgag gtcccggcgt
     4201 ttgggtcgta gctcctcggg ggcgtcgctg acgaccgcgg acagcttttt cgtgtgcacc
     4261 gtgcgaaggg cggtgggcgg gtcccctacc ccgtcgagac cgtccagccg ctggggatgg
     4321 tcggtcgcga cgatggagta gacgtatacg gccatggctc attccttccg gtgccggacc
     4381 gggcgacgag ccggccgctc ccgcttttcc gcgtgctcct tgcgccgctc cgcgggttcc
     4441 tcgtcgtcct cgtcgtcctc gtgtccgccc ttgagagctt cggtcaccgc ctcggcggcc
     4501 ccgctcagcg cacccttggc cttgccgtgc gagccaccct cggtgacctc gccgacgatg
     4561 tcggtcagct gggagggcgc cttgcgcccc tcctccaggt cgaggcggtt gcacgcctcg
     4621 gcgaagcgca ggtaagtgtc cacgctggcc acgacgatac gggcgtcgat cttgaggatc
     4681 tcgatgccga ccaacgagac ccgtacgaag acgtcgatga ccagtccgcg gtccagaatc
     4741 agatcgagga tgtcgtagag gttgccggag cctccgccgc cacctctggc gacggttcct
     4801 ccgctttgcg gcaccacagt cacggtgcct cccttccccg gctcgcccct tcctgcgcgg
     4861 agtggccgtg tagttcgctc ggcgaacggt tctgcggtgg catccggagc cttcaggtgc
     4921 cccggtcgat ctgacttcgg gtgtagcgac ggatgcgctc gtatgccacc agttcacctt
     4981 ccttgtccag caccacccgg taggtcgcca tcacgctggt ggtcgacggg acgcgctcca
     5041 gctccaggac ttccacgtcc gcctgccagc cgtcctccgt gggtttcacc gcggagacgg
     5101 actcgggggc ccgccccaga agctgctgga gctgctccgc cgcgttccgc atggcccgcg
     5161 gcgccgaaac tcggccggcc acgcgctccg gctcggtctc gcccttccgg ctgtcggccc
     5221 gagcactgct ggttgtcctg gcggtctttt tggcggtctt cttaccggac ggacgccgaa
     5281 cccgctctgt ctcgtcctct tcgcctgcgg ccatgttccc tctccggaac ggagacgaca
     5341 cgctgcccgc gccacgttca agaagcgcca ttacatgata tacatccaca gctcatcgca
     5401 actctgtaca tctcgggcac agcgcgtacc cgagtgccgc accacagtga gcggcgtaac
     5461 gtcggcactg tcccgtggga gacgtcatga cgacagctgt gtgaaggtgc gagatgagcg
     5521 acggagccgg gtccgaccct gtggaccggg cgcttcttcg ggcgatgcgg gagaccgggg
     5581 catccgcggg cgggctctac gtgctggcgg ccgacgagcc ggtgctgcgg ctgaccgtca
     5641 tgagcggggt tccggcgccg ttcctggagc cgtggagccg ggtcgcgctg gcggccccga
     5701 ttccggtcgc tgtcgccacc cgccagcagc gtctggtgtg ggcggccggc catcagcagc
     5761 tgacccgtga cttcccccgt acggcggtgg ccgtcccgta cgacttcgcg ctggccgcgg
     5821 ctccgatcag cgacgggacc gggcgccggg gcgccttgct gctgctgtgg cccgccggcc
     5881 atccgccgca gctgtcggcg gacgaggccg aggcggtgcg ggccggctgc cggcgtctgg
     5941 cggcgctgct ggcgacgagc cccctgccca acggggagcc ggccgaggtg ccgcgcgtgc
     6001 tgtcaccgcc cccggtacgg accgtcggcc gggtggaggc gctggcggcg gtcgactacg
     6061 tggagcggct gcccggcggc tgctgcgcgc tggacctcga cggctgcatc accttggtca
     6121 cgaccggcgc ggaggaactg ctcggcgaag aggacacccg gctcatcgga tcgcacccct
     6181 gggaagtcct gccgtggctg cgcgacccgg tcttcgagga ccgctaccgc gccgcggtgc
     6241 tcagccgccg gccgacgtcc ttcaccgccc tccggccccc gaaacagtgg ctcaccttcc
     6301 gtctgttccc ggacgcccgg ggcctgagtg tgtggatcac cccgtcgggc gaggatcacg
     6361 acccggtggc gtcctacccc gcggagaccg tacccgtgcg ggccgggcag atctaccacg
     6421 tcctgcatct gtccgcggcg ctcaccgagg ccgtgggcgc agcggatgtc gtcgatctgg
     6481 tcgccgacca gatcgtgccg gccttcggcg cccaaggcat gctcatgtac gcggcggagg
     6541 cgggccggct gcgcaccatc ggccaccgcg gctaccccgc cgaagccgtc gccgccttcg
     6601 aaggtgtcgc cctcagcgcc gccaacagcc cggccgtaca cgccctcgcc accggcgagc
     6661 ccagcttctt ctcctccccc gaggagttgg aacgcgtcta cccggggctg ccgcatctga
     6721 cgggcaaggc cgcccgggcc gtgctgccgc tgatcgtgtc cggccgcccg gtcggctgct
     6781 gcatcctcgg gtacacccga ccccgcacct tcagcgtgga agaacgccag gtcctcacct
     6841 cgctggcggg gctgatcgcc caggcactgg accgtgcccg gctgtacgac accaagcagc
     6901 aactcgccca tgatctgcag gccggactgc tgccgcacag ccttcccccg gtacccgggt
     6961 tcgccgtcgc cgcgcgttac ctgccgtcga cccgcggtat ggacatcggc ggcgacttct
     7021 acgatctgat ccggctcggc aaagacagcg tcgccgccgt catcggtgac gtacaggggc
     7081 acaacgcggc ggccgccgcc ctgatggggc aggcccgcac cgccgtgcac gcctacgcca
     7141 ccgccggcgc ctcaccggcc gaggtactgg cccgtacgaa ccggctgctg accgatctgg
     7201 acccggatct tttcaccagc tgcctgtacg tccatatcga tctgctcacc cggcgggcgt
     7261 gcctggccag cgccggccat cccccgcccc tcctgcgcca ccccgacggg cacaccacgg
     7321 tgctggacgt accgcccggg ctgctcctgg gcatcgagcc cgatgcccgg tacgacgcca
     7381 cggagatcgc cctgccgccg gaatccgtgc tggtcctcta caccgacggc ctggtcgaag
     7441 ccccgggcgt cgatctggac cgcgcggtcg ccgacctggc cgggcgcctt gacgacgctc
     7501 cgccacaggg gcccgacggc ctcgccgacg cccttctgca gaaccggcag gacgaggcgg
     7561 accggcagga cgatgtggcc ctgatgctcc tggcctcccg gccgatcgcg tcgacggcag
     7621 ctgcctgagc ccggcggcac ctcaacccgc ctttgccggg cgggcgttga cgaacggagt
     7681 ggccagcgcg cgctgcgtcc ggctgaggag gccgctcggc gcgcgcctgc gcagggccgc
     7741 gcgggccgcg ttggcgccgg gggcaccgtg cacaccgccg cccgggtgcg cgccggcgga
     7801 tgccagatag aggccctcga ccggggtttc cgggcggccg aggccgggca gcgggcggag
     7861 aaccagctgc tggtggacgg cggtggtgcc accgttgagg gcgccgccgt gcagattggc
     7921 gttcatcgcc tccagggtgg gaggggcgag gatccggcgc gccctgatcc ccgagcggaa
     7981 gccgggagcg aagcgctcga cctgtgcctc cacccggttc gccatcattt cttgttcccg
     8041 cgggtcccag gctccggtga tcccgtcctc ccccgcgtcc ccgcggatcc catggggtac
     8101 atgggtatag gcccaggccg actcggtgcc ggccggggag cgggtggcat ccgcggtggt
     8161 catctggccg aagaggacga acggccggtc cggcacctgc cccatggcga tctgcgcggc
     8221 gaagcgggtg agttcgtcca tcccgtcggc caggtgcacg atgcccgcgg tggcggctcc
     8281 ctccgcggtc cacggcaccg gaccgtcgag cgcccagtcc accttgaagg tggcgaagtc
     8341 ccattggaag cgccgcagat cggccaggag cgggccgggc agataccggg agtcgaccag
     8401 ccggccgtac agggccggta cggacacatc cgccagtacg gcgcggcggg ccggcacggt
     8461 ctcgccgatc gcggtgcgta ccgccaccgc gcgcccggag cgtacgacga tgccgacgac
     8521 gcgctccccg cagcgcagta cgccaccgct gcgctgcagg cgccgcacga gcgccgcggt
     8581 gagcgactgg gcgccaccgg ccggtaccgg aaagccgcag gtctggccga gcatcgacat
     8641 cagccacccg aagccgccac tgcccgccgc ctcgggggcg aggtccgcgt gcagggcgtt
     8701 gccggccagc aggagccggc cggcttcgcc gcggaactcc tcatctccca ggcgccgtac
     8761 gggcagcagc atcgtgcgcg ccagccgcag accgcccgcg ccgcgcagcc gcgcggcgag
     8821 ccgggccgtc gcgcgcagcg gcgggaacgg ggtcaacatg gcgtcgacga ggtcgctgcc
     8881 gacgcggtcc cagactccgc acagcgcctg ccaggccgca ccgtcaccca cgccgaaggc
     8941 ctccagcccg gccgccgtgt cggccgtatc gcgctccagc agcgcacagc ggccgtcggt
     9001 cagcggatgc gccagcaccc gtggggcatg gctccagacc agcccctgtt cgtacaggcg
     9061 gagggccgag aggaccggcg aggcggcggc cagcgggtag aaggagctga acaggtcgtt
     9121 gacgtagtcg gggtgcaccc cgcggtcgct gcggaccgcg ccgcccggct cgttctgctc
     9181 ttcgagcacc tccacggtcc atccggcgtc cgccaacagg ttggccgcga caagtccgtt
     9241 gggcccggca ccgatcacca ctgcgtccgg catcgctgtc tcctgttcac ccggccgtgg
     9301 ccgtcggcac agtcggcggg gcggcggtca ggggcctgtg tgcgcgccgt gcggggcgtt
     9361 ttcggccacc gccgccagcc tgctgagcat gctgcggtgg cgcagctgca gcaggaattc
     9421 caggcccgcg ttgtgcagcc gcccggcggg gccgcgcagc ggatgctcat cgacgatgac
     9481 cagcgaatcc tcgccccagc tgcgcacttc gacggcgatc cggaccgtgc ccagccggcc
     9541 gctgtcgact tcgagttcga gttcccgtgg cggggagctg tgccgtacga cggtgtggcc
     9601 gatgaggtcc cagggaccca ggcgcaccgt gtactcgatc gcggagccga cctccggcca
     9661 gttgccgtcc acgggacgcg agtgtgcggt gccgaccacc cagtccgcgt accgggagcc
     9721 gtcggcaagt accgcccaca gcgcctcggg agagcgcttg atcagctggt gccgtaccgc
     9781 cacaagcctt ccaccgcctc accgcacgtc ggccttcggc ctcctcaccc agcgtagagc
     9841 gggcccgcgg gctcggcctc ccgaggcgtt tccttctgtg ggccggatcg ttgaggcagc
     9901 cgtggcagct gtggagagtg caaacaacca ggccgggggc ggtgccacgg cgcctggaca
     9961 cgaccccggg gagacgcggt ggcgactggg gtgccggctg gtgacggggt ccggggacgc
    10021 gtacgtggtc gcggcggacc tcgtccggca ccgcaccacg gcggcggacg gatcgccggg
    10081 gtggggacac ggcctggtct ggtcgttcat cgatgtgcgg cggcgctccc atgcggccga
    10141 gtcatgggtg gaccggggcg cggtcgacgc cttccgcgcg gcggcggccg gggcgatgga
    10201 tgcccgggtg cgggcggcgc tgctggaggc cttggcggcg ggcttgccgg tggcgccgga
    10261 ccggctgctg ccggatccgg tacgggtcgg ccccggcccg ttcgacatcg gcttcggcgc
    10321 ggcgggcacg ctgtacgagg agcaggacgg cggccggtac gggctcacgc tgcgcggcga
    10381 gcgcgcgcac tgcgacctgg tcttctcccc cgtaccgggc ccggcctccg cggggacgac
    10441 cggcgacgca acgtacgcgc cgcgctacgc cgtcgccggc cgggtcggcg ctccgggcac
    10501 ggagggcacg atcgacgtct cgggcgaggg ctggatcgag accggctcgg gcgaggaccg
    10561 gtgcaagacc ggccgggacg aggaacggtg caagaccggc cggggcgacg gccggtaccc
    10621 ggccgggccg ggcggtgggc cgctgtcgga cgaactcccg gccgggacaa gggacatcgg
    10681 tcggcaacgc ctcaccgtgc tgctggacga cggctggcgg gtgacggccg agagcgtgga
    10741 tcacgtcgac gtgccctcgc gcgcggtgct cgcccatcag gacctgctga cggcatacgc
    10801 ccccgacggc cgggcactgc cggccgatga cgcgcgctgc cgctccgccg ccccctggac
    10861 gtccctcgcg accctgaaca cctaccccac cacctggacg gtcacctccg agcaactccg
    10921 gctgcgcctc gacgtcacgg cgcacttccc cggccaggaa gtgcgcacca tgctcgccgg
    10981 ccacggcttt ctgtgtgccg cggcgcgggt cgccggtacg cgggccggcc gggcggtgac
    11041 gggctgggcc ctcgtgtcgg ccgtgcccgc gcaacggatc ggtgacctgg aggagtatct
    11101 gggccggctg cacaaggtga cccggcgtga agtccgccgt ctgtaccccg accggccgtc
    11161 gtccgcgacg accaggtccc tgctcggcgg gaccggcgcc tcgctcgacg gcttcacgga
    11221 caccgccgtg caccagaccc tggtacgccc ggtccggcat ctgaccgacc ccggcggccg
    11281 cggctggcgg acgtacgtct gctgcgccgc catcgaactg gtgggcgtcc gggccgatcc
    11341 gtacacgccg ctgctggccg cggtcgaggt gatccacagc gccaatctgg ccatcgacga
    11401 cgtccaggac ggctcgctcc accgccgcgg tgtgtccgcg gtgcaccggg tcttcggggt
    11461 tccggccacc gtcaacgccg ccacggccgc ctacttcgcc ctggaccggg tcatcgacga
    11521 cctggtaccg gcggacgacg ggctgaagct cgccgtctgc cggacgtatc tgcgcacgct
    11581 ccgcgcggcg cacggcggcc aggccctgga tctggccggc cacaccgagg agatggatgc
    11641 cgcggtggcc acgggtgacc cgcggccgct gctgcggcgg ctgcgggcgg cgcaccggtt
    11701 caagaccggg gtaccggccc gtggtttcgc ggagctcggc gcccttgtcg cgcgggccga
    11761 cggcgcgcaa cgcgccgcca tcggcgccta cttcgaggcg gtcggcaccg cgtaccagat
    11821 ctccgacgac gtgctcgacc tgctgggcgc caccgccccg cagccctccg gcagcagccg
    11881 caaacacacc ggtgaggacc tgcgttccgg gacggtgacc atgccgctcg cccactgtgt
    11941 cgcgctgctc cccgccgacc gggtgcgcct gctgtggaag gccgtacgcg acggcggcgc
    12001 cgatgcggac accgtgcacg gcgtggccac cgccatcgcc cggtccggtg ccgtccaggc
    12061 ctgccaacgg gaggcgcggg cgctggtcga cgacgcctgg cgcacgctcg cgccgctgct
    12121 gccggcttcc ctgaccaaga tcctggtccg ggcgctggga acgtacgcgg ccctgcgcga
    12181 accggagccg cccgccgcgc cggcgccccg cccgaagtga ccgggcgggg cgcttcgatg
    12241 cctccggcag caccgtggtc gatgtgatcc gggagtccgg aaccggaacc tgttacgccg
    12301 cgactatccg ggggacccgc gcggaggtct cggcggacct cagccactcg gtgaggtcgg
    12361 cgcgggcccg ggccacccgg gagcgcacgg tgccgaccgg acagcccacg accgccgctg
    12421 catccgcgta aggcagtccg accaactgcg tgagcacaaa cgcctctcgg cgctcgcgat
    12481 cgagtgcgtc caggagttcg ctcagcgcca ggccgtcctc gaatcccggc agtccgctgg
    12541 gttgccggtg ctccgccacc gtctgccagt cgttgatgtc ggcgatacgc ggacgggcgg
    12601 cggcggagcg ataacggtcg atcaccaccc ggcgggcgat ggacaacagc caggtacgtg
    12661 cgcaggagcg gccggcgaat ctcggcaggc tggtgagggc acgcagaaac gtctcctggg
    12721 ccagatcgtc ggcgccgttc atatcgccgc tcaggtgggc cacgaaccgc cagacgtccc
    12781 ggtgggtggc gcggacgaag cgctcgaccg cgtcggggtc tccgtcccgg gcggcgagcg
    12841 ccaagccggt cacctgctcg tcgtccgcgg cggtccgctt gctacgggcc ggtccaagaa
    12901 gggcaggaat catcgtaaaa catccttcgg aggctccggg gcgactgcgc cagggcaggg
    12961 cagttcccca tcggtgggcg gcgctccgag cacccgcgcc aagatcggcg ggcgtacgtc
    13021 aggggtacct cgggggtacg gcgggcgtac gccttcgggc aggccggagg gccgtatgac
    13081 caagggccgg catgggaagg gcgcgcttac agaggtaggc cacgcggata cgccggcact
    13141 ccgcccgcca ccggatcaac gcgcctcggg gattcggaga atcgcaaaaa cgtcgaagga
    13201 atgtggggac gagcggtcag cagaccgaaa gcctcggtgg gcccctgcgg gagacggcat
    13261 attgcaacaa cgccccgcgc agacacaaga catgggagct caccacccgg cgtacgggca
    13321 gcttcccacc ggtccggccc agcgtgcgca ggaccagcag caggggtgcg aacagcgccg
    13381 ccgccagact gcgagccagc tggaacacgg ccgcctcgcc gcgccacagc cagattccgc
    13441 acacgaacgc ggccagcgcg tgggcgagga acatgccgag tgttccgtgt ccggagtggg
    13501 tcatctgcag gtgacccatg tgccccatgt cgccggccat ggcgcctgta tgacccatgc
    13561 cgggcatcgt gaccatctcg gccattccgc gcattccacg catgccgctc atcggtgtcg
    13621 gcggaggcgt ctgcgtcgcc agcgggtcga gaccggcttg gcgcagcagc ctgagcgccg
    13681 aggcgcggag tgccggatcg accccggacc cattgcagaa cagccgctcc gcccactgtc
    13741 cgtcggacga ggcggcgata cccgtaccgc ctgcggactg ctgcgagaag ccgaacagcg
    13801 agtgcagtcc gagctgggcg aacaccgtgc atccggtcac gacaactgcg ccccgctcgc
    13861 gcccggtcag ccaccacgcc gcggcgccgg tggccccgaa tgcggcgatc acggcccacc
    13921 acggcaccgg ctgagcggac atcagcccgt gccccaggac cgtcgtcatc acgcagacgg
    13981 tcgcgaagat cgcggctcgt gcagcgcgtg aggccggccc ggttgtcatg ccggacatgg
    14041 tgccatccgg cccgtgcacc gcggcagggc gggtcggcgc gcgtatcgac ggccgccccg
    14101 tatgccactc gggcccggcg tcggcatttt gacgatccga cgtgtgccgc acgtcacccc
    14161 ccgccttcgg aaccatccct tccggtcgcc cgactccctg aagcggcacg gctgccggcc
    14221 ctgccacctg acctcgaacc gggagacccc gcgtgcccac gcccaccgaa gagaatgtcg
    14281 cgcccggcga tgccccggac atcgcgggct ccacggagca gcggcccgcg cggcgagccg
    14341 gctgggccgc cctgcgcccg ctggtgctgc gcctgcactt ctacgccggc gttctcgtcg
    14401 ccccctttct cctcgtcgcc gcggtcaccg gcctcctgta cgcctgctcc ttccaggcgg
    14461 agaaagtggt ctacgcgcat gagctgagcg tcccggtcgg tacgcgcacc ctgccgctgt
    14521 cgcagcaggt cgccgacgcc cgtcaggccc atccggaggg caagctcgcc gccgtacgcc
    14581 cggcgccgca gccgggagac accacccgcg tcctgctctc cgacgtcccg ggcgtgcccg
    14641 ccggccacca gctcgccgtc ttcgtcgacc cctacaccgg cagtgtccga ggagcgctgg
    14701 agacatccgg ttccacgggc gcgctgccgc tgcgcacctg gctcgactcg cttcacggca
    14761 atctgcacct gggcgagacc ggccgcctct acagcgaact ggccgccagc tggctgtggg
    14821 tggtgaccgg tggcgggctc gccctgtgga tcggccgtaa gcgcacgaac cgcaagctgc
    14881 gggccctcgc gctgccggat cgccgcgcca ccggccgccg ccggacgctg tcctggcacg
    14941 gcgcggtggg cgtgtgggcg gcagccggcc tgttcttcct ctccgccacc gggctgacgt
    15001 ggtccgcgta tgccggggcg aacatcgacg atctccggaa gtccctggga caggcgaccc
    15061 cgaccgtctc gacggccgtc gccgagggcc atgggcagca ctcgggcgcg gcagggatgg
    15121 cggggatgcc tgacatgccg ggcatggagg gcatgcacca cgacgggtcg gccggatccg
    15181 cgccctcgga cgtcggcatc aaccaggtac tcaaggcggc ccgcgcccag ggcctgtccg
    15241 accccgtaga gatcgttctg ccgacggaac ccggcaccac ctacctcgtc aagcaggtcc
    15301 ggcgcagctg gcccgagaag caggactccg tcgccgtgga cccggccggc ggcaaggtca
    15361 ccgacgtcct gcgcttcgcc gactaccccg tccttgccaa gctcacccgc tatggcatcg
    15421 acctgcacac cggcatcctg ttcggcctcg ccaaccagat cgcgctggcc gcgctcgccc
    15481 tcgcactgat cttcctcatc gcctggggct accggatgtg gtggcagcgc cgccccaccc
    15541 gcgaacgcgc tctctccttc ggccgtccga taccgcgcgg agcctggcgc caggtcccgc
    15601 tgcccgtact gattccgctg gtaccggccg tcggagcagt gggctgggcg gtgccgttgc
    15661 tcggcatcac gctcgtggcg ttcctggccg tggacctcgc actcggcgtg atcgcgcgcc
    15721 gccgcgcctg agcgggatct caccgctctg tccttttgtt gcccaactcc attgaggtat
    15781 ggacgagttg acggacaccg ccgctttccg tcgaccgacg tactcggcag cgcgccggcc
    15841 aggacatccc cgcgccaggc gcctgctcct ttgctccttt cggcgcgcgc gatcgcaccg
    15901 gagctggtct gctggtagag ggctttccta cccgtacacc ggagagatcc agatgagcgt
    15961 ttatcgagtc gcgcaggtcg acacggccgg cgggccgttc gagatcgtcg agcgggaggt
    16021 gccgcagccg ggcccgggcc acgtacggat cgccgtggac gcctgcggga tctgccacag
    16081 cgacgccttc ttcgtgaacg ccgcattccc cggcgtgcgg tttccgatgg tccccgggca
    16141 tgagatcgcc gggcgcatcg aggaggtcgg cgagggaacg tacagcggct ggcaggtggg
    16201 cgaccgggtg gcggtgggct ggttcggcgg cagctgcggc cactgcacgc cctgcagaca
    16261 gggcgacttc atggtgtgcg agaacctgaa ggtacccgga tgggcgtacg acggcggtta
    16321 cgccgaggcg gtgatcgcac cggtggacgc gctggcccgg atccccgatg cgctggcggc
    16381 gcccgatgcc gggcccctgg cctgcgcggg cgtcaccacg tacaacgggc tgcggcgcag
    16441 ctccgcccgg tcgggggacc tggtcgccgt cctcggcatc ggtggcctcg gccatctggg
    16501 agtgcagtac gcggccgcga tgggcttcga gaccgtggcc atcgcccgtg gcgccggcaa
    16561 ggccgacttc gccaagcagc tcggcgcgca ccactacgtc gacagcacgg cggacacccc
    16621 cgtcggggac gcgctgcagt ccctcggcgg cgccaaggtc gtcctggcca ccgccgccaa
    16681 ctccgaggcc atcacggcga ccgtggacgg gctgacccac cgcggagagc tggtggtcat
    16741 cggcgcggac cccgacccgc tggggatcag cccgacccag ctgctcatga gcggcaagat
    16801 cgtccggggc catccgtccg gcaccgcgca ggacgtgcag gacaccatgg cgttcagcgc
    16861 cctgcacggg atccgcccga tgaccgagat catgccgctg gaccaggccc cggacgcgta
    16921 ccagaagatg ctctccggca ccgcccgctt ccggatggtg ctcaccaacc gctgacgcag
    16981 ccccctcacc tcttcaccgc ggcccggccc cccgccggga ccgggtgggc gttcggtcgt
    17041 tccgcggggg accatggatg ccgaagcact caccagacag ggggcggcca cggaccggag
    17101 cgaggggacg gcccccgtgg tccgtcgagc ggaaggagtg cccgggtgag cgcagccgac
    17161 gggcgtccgg ctgacgcggg tgagcccgag gacaggccgc cgcggccgag cgggctgatg
    17221 gatctcctcg gtgtcgccgc ggtgctgctg gacgccgagg ggcggatcgt cctgtggagc
    17281 ccgcaggccg aggacctgta cggctacacc gccgacgagg cgctcggaca gtacgcagcc
    17341 ccgctgctcg tccacgaaga gcactgggac ctggtgatga agaagtttgc cgacgtcatg
    17401 gagaccggcc agagctgggg cggctcattc cccgtccggc acaaggacgg caccgcgcgg
    17461 ctggtggagc tgcgcaacat gcggctgctg gacgaccgcg gcgacttcta cgccctcggg
    17521 ctcgccaccg actcaccgac gctgcgcgag gtggagcggg atgtcgcact gtccacccgg
    17581 ctgatcgccc agtcccccat cggggtggcg atcctcgaca ccgatctgcg gtacgtggcc
    17641 gtcaaccccg ccctggagcg gatgcacggc atccccgcga aggaccacct cggccggcac
    17701 taccgcgaga tcatgacctc cgcgaagttc gcggtgcccg aggccgcgat gcagcaggtc
    17761 ctggagaccg ggactcccct ggtcgaccac tccaccatcg tcggccgcac ccccgccgac
    17821 ccggaccaca agcatgcctg gtcgatctcg ttgtaccggc tggaggaccc acaggggcgg
    17881 gttctcgggg tggccgacct cgtcgtggat gtcaccgacc ggtatcaggc agccgtggag
    17941 gccgccgagg cccggcggcg cctggccctg atcgccgacg gctccgcccg catcggcacc
    18001 accctggagg tgggacagac cgcccgcgag ctggccgagg tgaccgttcc cgagctcgcc
    18061 gacgtggtca cggtcgatgt gctcgactcc gtactggacg agcaccgccc tgcccgcgga
    18121 gacggccccg cggtcttccg cgccctcgcg gtgcgggccg cctaccccac cgaagccgcc
    18181 caggccgccg atccacccgg cgagatcgcg gcctacgaca ccgaccgcct cgccacccag
    18241 tgcgtgcgca ccggccgccc gatcctgatc tcccacgcgg acgacagcga cctggcgcgc
    18301 atcgcccgcg acgaccacgc cgcctctttg ctggcccgcg ccggggtgca ctcctacatg
    18361 ctggccccgc tcaccgcccg cggccatatc ctcggttgcc tggggctcag ccgcgcccgc
    18421 aacccgctgc ccttcgacga ggacgatctc gccctcgccg gcgagctggc ctcccgcgcc
    18481 gccgtgtgca tcgagaacgc ccgctcgcac cagagcgtgc gcaacgccgc cgagaccctg
    18541 cagcgcagcc tgctcccgga ccacccgccc caccttcccg gtctgcggat cgcctcccgg
    18601 taccggcccg cactggccac gtacgagatc ggcggcgact ggtacgacgt cctcccgctc
    18661 aacgacgaca agaccgcgct cgtcgtgggc gacgtcatgg gcagcggcat cgacgccgcc
    18721 gccaccatgg gccgcctgcg caccgccacc agcgccttcg ccgacctcga tctggacccc
    18781 gcccaggtcc tccagcacct cgacaagatc acctcagggc tggagcacta catcgccacc
    18841 tgcgtgtacg ccgtctacga tccccaccgc gccgaatgcc atatcgccac cgccggccac
    18901 cttccgccgg ccctcgtacg ccgcggcaag cgccccgaac tcctcgacct gcccaccggc
    18961 accccgctcg gcgtcggcgg cgtccccttc gagaccacca ccttcggtct cggccccggc
    19021 gacaagctgg tcctgtacac cgacggcctg gtcgagaccc gccaccaccc catcgacgag
    19081 cgcctcgaaa ccctccgcca gctgctcgat gcgcccgacc gctccctgga agagacctgc
    19141 gaccggctcc ttcgcgaact ccggcgtccc gacgacccgg atgacgtcgc cctgctcatc
    19201 gcccgcacac agcccttccc ccctggctcg tagccaggtc cggggcgccg gaagccgagc
    19261 aggtcgatcg aggcccttgc cgcgagccgg cagcagttgc cgtcgcaaga ggccaggacc
    19321 acagtgagag ggagtgtgca cacgagatcg gagagacccg tgatcgttct cggcatcatc
    19381 ctgctggtca tcggcttcct gaccggcgtc ggcattttgt ggaccatcgg gatcgtgctc
    19441 gccgttctcg gggcgatcct gtgggtcctg ggttcactgg gacacgcggt cggcgggcga
    19501 aggcactact ggtagcgcca ccccgcttcg gccgccacgg cctccggcgc cgcccgctgc
    19561 gggcggcgcc ggaagtgtcc gcgggcgaag gaggttcact gcccgggaca cgtacgcgcc
    19621 gtaccacccg ttaaaggcga cttaccgacc gttccgaacg gcgtccagcg ccggggcgat
    19681 cacggcgaag gcccggtcgg tcagttcggc ggggtcctcg gcgccgtcgc tgttgctcca
    19741 ccgttgaagc acggcgtcga aggcggtcaa cgccatcccg gcggccagct gcgagtacag
    19801 atcggtgtgg gcgtcgagcc ccaggcggcg cgccaactcc cccgtcaggt cgtcgcgcca
    19861 ctgcgcctgg cgctccagaa agcgtgcgta cagggcgggg gtgcgcagaa tcagctgcac
    19921 cacgcgcagc gccctgtcgg agtggtcgcc gcaggcagcg atggagaccc agacggcgtg
    19981 ccgtagcgcc acggaggggc gctcctcgat ggggcgggcc gccaactccg cgtgaatgcc
    20041 ggtgcccata tcggccagga attggacgac cacgtcttcc ttggacgcga agtaccggaa
    20101 gaacgtgcgc ttggacaccc cggcggtggt cgcgatctcg tcgatggtga ccgcgtcgaa
    20161 ccccttcagc gccagcagct gcagtgccgc ttcggccagc tcgttcgaga cgagctgacg
    20221 tttgcgctgg gccatggtga cttcagggcg ggagctcacc gggcaatggt aacgccatgc
    20281 ctcgtatggc actcagtagc gtcttgacac cgagtgacac tagcgacagc atgtgccgca
    20341 tgacacagca gcggcactgg actgccgagc agatcccgga ccagaccgag cgagtgttcg
    20401 tcgtcaccgg agccaacagc ggcctcggcc tggcgaccac tcgggcgctc gtccgccggg
    20461 gcggacacgt gatccttgcg gtgcgcgaca ggacaaaggg ccaccgggca gtcgcggaga
    20521 tcaccgccga gcagccggac gcgagccttg aggtgcgcca cctcgacctg gccgatctcg
    20581 actcggtccg agccttcgcc catcagttgc acaccgacca tccgcggctg gacgtgctca
    20641 tcaacaacgc cggcgtgatg gcgccgcctc gatcgctgag cgcgcagggc cacgaggcgc
    20701 agttcgcctg caaccatctc ggccacttcg cgctcaccgg actgctgctc gacctgctgg
    20761 ccgtcgggca caacccccgc gtggtcacgg tgagttcggt caaccaccgg caggggcgca
    20821 tccacttcga agacctcacc ggcgagcgtg gctacaagcc catggccttc tacaaccagt
    20881 cgaagttcgc caatgccgtc ttcggacggg aactccaccg gcggctgacc gaggccggca
    20941 gccccgtacg cagtttgctc gcccatcccg gctataccgc caccaacttg cagatgagtg
    21001 cgccggtcgg cctgtggcgg gtgatattcg gccacatcgg caacccgctg ttcgcccagc
    21061 caccggcccg cggcgcgttg ccacagctgt acgcggcgac cgaaccgaat gtggagggcg
    21121 gtgcgttcat cgggccggac ggcccggccg agctgcgcgg cggaccgaag cgggtacagc
    21181 tgtcccccgc ggccgccgat cgcgaaaccg gccgccgtct gtgggagttg tcggaacaat
    21241 tgaccgacgt gcgattcgtg tagccaggaa gcgttggaga tgaggagcga gcgtgccgat
    21301 gtcccgcgcc gtggcggcga cccggtcttc tcgtaggtgc gaactgccgc tctcgccacg
    21361 gcccgtgcaa cggcgacggg acacgggccg aacgccctgg acggtggtgc tggacactgg
    21421 atatgacgca ccgtgtacga ctccaggacc atttgcccca gcagtccgtc cacccacagt
    21481 tggacacact gtgccctgct gagggattcg tcccaactgc cgtgtgcgca agggtgagtg
    21541 cgtcccacac gtactgaccc gaagggccat ccccacgtgc gaagcagacg aatagcccct
    21601 gtcctggctg tgagtgccgt cgcggcactg gttccggcac tcacgccggc ggccgcctct
    21661 gccgctgaga accccctacc gcagcacctc aagcagcgac cggcatggca ccgctgcagc
    21721 agcgcaaccc cggcctcctt tcagtgcgcc accatcaagg tcccgttgga ctacagccgt
    21781 ccaggcggca agaagatcga cctcgcgata tcgcggatca aggcgagcag ccccgccgaa
    21841 cgccgcggtg tcctgctgct caatcccggg ggaccggggg gccagggcct cgatatgcca
    21901 caggcgctgt cggccgagct ccccaagccc gtgaagggaa agttcgacct catcggcttc
    21961 gacccgcggg gtgtcggcca gagctctccc ctcaactgcg gtctgaccgc cgaggagcag
    22021 aactggcagc gtccctacaa ggccgcatcg ttcgccaagg acgtcaagtg ggcccggacc
    22081 gtcgccgaga agtgcgacgc caagcagggc gacaagctgc gtcacatcac cacccgcaac
    22141 accgcccgtg acatggacgt gatccgggcc gtgctgggcg agaagaagat ctcctacctc
    22201 gggtactcgt acggcaccta
//
