LOCUS       NZ_CP084681            21056 bp    DNA     linear   CON 30-APR-2024
DEFINITION  Streptomyces inhibens strain NRRL30439 chromosome, complete genome.
ACCESSION   NZ_CP084681
VERSION     NZ_CP084681.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces inhibens
  ORGANISM  Streptomyces inhibens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Gillane,R., Talbo,G.H., Plan,M., Palfreyman,R.,
            Haber-Stuk,A.K., Power,J., Nielsen,L.K. and Marcellin,E.
  TITLE     Multi-omic characterisation of Streptomyces hygroscopicus NRRL
            30439: detailed assessment of its secondary metabolic potential
  JOURNAL   Mol Omics 18 (3), 226-236 (2022)
   PUBMED   34989730
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Palfreyman,R. and Marcellin,E.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2021) EMS, Australian Institute for Bioengineering
            and Nanotechnology, Cnr College Rd & Cooper Rd, Brisbane, Queensland
            4103, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. APRIL-2018
            Assembly Name                     :: AIBN_shyg
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 239.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022221585.1-RS_2024_04_30
            Annotation Date                   :: 04/30/2024 04:58:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,775
            CDSs (total)                      :: 8,682
            Genes (coding)                    :: 8,305
            CDSs (with protein)               :: 8,305
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 377
            CDSs (without protein)            :: 377
            Pseudo Genes (ambiguous residues) :: 0 of 377
            Pseudo Genes (frameshifted)       :: 158 of 377
            Pseudo Genes (incomplete)         :: 310 of 377
            Pseudo Genes (internal stop)      :: 38 of 377
            Pseudo Genes (multiple problems)  :: 116 of 377
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:32:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1422043
            Orig. end                         :: 1443099
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084681.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Australian Institute for
            Bioengineering and Nanotechnology, Building 75,Cnr College Rd &
            Cooper Rd, Brisbane City QLD 4072.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21056
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="12"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21056
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21056
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11056](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11056
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    457..471
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
     misc_feature    620..634
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     misc_feature    complement(726..740)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            complement(1702..3981)
                     /locus_tag="KI385_RS06670"
                     /old_locus_tag="KI385_06720"
     CDS             complement(1702..3981)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS06670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_06720"
                     /product="hypothetical protein"
                     /protein_id="WP_238571284.1"
                     /transl_table=11
                     /translation="MPDAFRQNEPPRLDVTFHDYLVPRADPGVYTVHAEHLLKEADGTR
                     VDTDPLPAAEQKFEVRAARFTLHETSVHAYYPPAGTSGRYDAVLPHITLDRAILPWERS
                     LTGVRSRARAPWVALLVFREGELPDDPAAAGDTVLRTVAELIKPTEQDVIGPSNLRGIT
                     SGIAASKCATIDVPREVFRRVAPYQEEMYYLAHVRDVVRPVLGAQGEVLTEGKYAVVTA
                     NRFPREAGRYTAHLVSLEGYEAQLEPGAPGTHRALRLVSLSSWSFTTDLTHALDIPDML
                     QHLVEPSWSGDPEDLALRINPPKGEPADDAERYARARLALGYAPVPFRTLSGELTYAWY
                     RGPATPVTTPDVPGQAGESGHTTADHALIYERENGLFDVSYATAWTLGRTIALADPDYS
                     AQITRARRELGNRAATLRAMAADPVRARTDPDAGRGLAALHELAADGGRSLAAALTDRA
                     DPGPTPRVTGRRRLNRAEGRALLTEERSMSLLRATAERNTGDMPAWLDELGLLRGIPFC
                     YLVPDPRMLPPESMRMFRIDEQWLDAVLAGASDVGMHTSMDRDLDPQLRAVVGRSRRTE
                     LRPGAGLLINSELVKAWPDFPLVAKTADGTPIVELRQDRLATNLILYLFRDVPDVIEIR
                     EPGQGIHFGIDAGDRINLRSLGGAGNPPLGEDTGASFPAPDHPDTDTVFCTYLRDRPDG
                     GTKDVLRLCGDAGLVSGLAAAFELDDLTPSQFALQMVNSPVLQRLAPKPPAFPEATTAT
                     TTGSPR"
     gene            complement(3987..6755)
                     /locus_tag="KI385_RS06675"
                     /old_locus_tag="KI385_06725"
     CDS             complement(3987..6755)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020552174.1"
                     /locus_tag="KI385_RS06675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_06725"
                     /product="DUF6603 domain-containing protein"
                     /protein_id="WP_238571285.1"
                     /transl_table=11
                     /translation="MSPAAEQVTLLDMFNAIDQPMVELPDELVPYLENVVEHTGLPTGE
                     KLYTARSPGYDQPGEASPVDLLFVKTNKVGNASLSAAVLDIRIGFDASGLSLVGESIPT
                     GAFVFPTVRIVYMSRAIVVDEVNQLNRVLCGSGVTEPTFPLPNVMTEHAWPKKFSAVVS
                     WWVNGGELPALAISMDKEEKDKPSEPDKDIRVPGLPVSFGPVEIAAVRRSFDEKKGLRI
                     FLVGEFRLAGFTFQLDGLGIVVPLAGGFIPKPELMGAALDITRVKPPMQIMAAMRWAGA
                     RDPGIAGGLVGLVRVTTPAVEVLGAGGFFRATEGFNSVFLYVEALLAREARSLFGPSPF
                     TVTGLSAGFGINSTIRPPTAAQLPAFPLVSRLDEAPPTPADPTPDPPTPMDMLENLAGK
                     AGWVRPEDGSYWAAIGVRFTSFRFIETKALALVEFGNRLNLMLLGRTSVTFPKNADVGG
                     RVHARLNIDLRLAYLSDEHLISLDVAVAPGSFFFDPACELTGGIALCVWTGGGRGGDFV
                     ISIGGYHPQFALPDYYPRPARLGFRWNPCGRVVIQAQGYTALTPGAIMFGGALAARYER
                     GLLSAWFTAHLDALIQWKPFYLDIAMGVSIGVAFTIKVIVKIRVSIEVGIDLQLWTPPL
                     GGHVTVKVWFISFGFDFGSSRKGAPPVPWSEFQMQLPSPIRAKPEKGLLLDVDKSERQA
                     REAEQAPLLVSSDGFAFSTEAALPASVIRLNGQAIATAHNKIDIRPMGKTGLTSEHIVT
                     LDLDGVEYTPDPNLWTRTVIRRDLPRALWGKPVTKPSPKEPGLEPGLFTGLHFEVPGPD
                     LGPGLGPVTSAALGVEPQPEGYTPLREADSQGPEPGVDPDSVGVIVETLASPTTATRRS
                     AVYDALTRLGAAPGKDTDGALTDYARLVGRSMTDAPLTTAAPAMSTPIAAR"
     misc_feature    complement(6096..6098)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6804..8456)
                     /locus_tag="KI385_RS06680"
                     /old_locus_tag="KI385_06730"
     CDS             complement(6804..8456)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020552173.1"
                     /locus_tag="KI385_RS06680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_06730"
                     /product="hypothetical protein"
                     /protein_id="WP_238571286.1"
                     /transl_table=11
                     /translation="MPEHQVDAFFTTANAGQGAEQTGFVVQGDRAARFGWGSHRMLDGA
                     LALARRWPDLPAAFRSGFDATLTTPLDDPWTIVFRGTQCLRLHPLDETVAEVTTIAARF
                     PGLPAVFASGVDAALPGSSGNQAFLFRGNQCVLYDMRAHAVVETKTLAEMWPGLQAKAP
                     EFVNGISAATYDPSKGEFHLFRGAHYAKGVLATRTVTTDAAVVDESSWPGLVPTFARGH
                     VYAQDGYANHSTVESVDVETGKVTFSHKVRGSYLTRHAIAVSPDGRYVYIRSVSTWMCF
                     DTTSNLLLAETPVTEDTYASSNVGFSPDGLHIHGIIRTFDPSVFHLDTFRVGTAERTRR
                     IEVRGTDLFDDPAEAAETGGLALWDTPILTAPGGRYLYFGGSLDGDAVVIEVDDEASRV
                     RQAFRIPNSTKFEDLAISSDGLFVHVATQTDVVTVDVRNGSIRCRGVLPHCRNVALTPD
                     GQSLYCLPDAEKSGVLVADPVDHRVRHRIPVSAQGGLGSPRGIAFDFAGTYAFVGDPES
                     ISVSVIDTDEHVLDRTMPMTLKIGPGAVAFTIY"
     gene            complement(8531..8740)
                     /locus_tag="KI385_RS06685"
                     /old_locus_tag="KI385_06735"
     CDS             complement(8531..8740)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS06685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_06735"
                     /product="hypothetical protein"
                     /protein_id="WP_238571287.1"
                     /transl_table=11
                     /translation="MVDEVDLDENVLRRTFALPGRGRSGGVTLRGTLPTDTTIALRLDH
                     REPPCPPAISNSGVPVADPVGHRR"
     gene            complement(9214..9615)
                     /locus_tag="KI385_RS06690"
                     /old_locus_tag="KI385_06740"
     CDS             complement(9214..9615)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS06690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_06740"
                     /product="hypothetical protein"
                     /protein_id="WP_238571288.1"
                     /transl_table=11
                     /translation="MYDGLLSRPVVGRYEIDAMNLDLVTDGTRLTLAVDTKPAIREASD
                     EEMPPGYPAAAIGFLPGDGDEYIVTWSPPSVPRGRRTRRVCLPAAAAVADVACGPVGGK
                     WRAILACWSRMIALRSRTGNSWQGSMPGM"
     gene            9733..10011
                     /locus_tag="KI385_RS06695"
                     /old_locus_tag="KI385_06745"
     CDS             9733..10011
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379395.1"
                     /locus_tag="KI385_RS06695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_06745"
                     /product="polyprenyl synthetase"
                     /protein_id="WP_238571289.1"
                     /transl_table=11
                     /translation="MTRDTGAREGLDGQAMLLAAGLADLAVSTLGSAFGAVRGLLRRSD
                     AAELAAEAEQDLVARGRLVLDRYASAPPAHLEVLAQHVLARRADDGV"
     gene            10001..11056
                     /locus_tag="KI385_RS06700"
                     /old_locus_tag="KI385_06750"
     CDS             10001..11056
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956355.1"
                     /locus_tag="KI385_RS06700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_06750"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_238571290.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 7.8e-35, bitscore:
                     119.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASERWEPTAFKARVDEVLQRFVARETDQLSAIAPALNPVAGQVE
                     AAVADGKRLRAAFCYWGWRAVGQPDSDALVRAAASMELVHAAAVVHDDLIDDSPLRHGR
                     PTAHVALRGAVEHHPRAAAAARSLAMLVGDLLMSLAGQLFVTSGLPAAYLGRARPLWAA
                     LARDLIAGECLEILHTGAAPDTAASLKVIRYKTAKYTVEQPLLIGGTLAGAGERMREGY
                     SAYGLPLGEAFQLRDDLLGVFGDPELTGKSGADDVRGHRPTALLAETWRLAGDNERERL
                     RALLGQRDPDGDGLEAVREVMRRLKAPDRIENMITARVEEALCALDELTLPAPAAAALT
                     ALAHSAAVRRS"
     gene            11077..12240
                     /locus_tag="KI385_RS06705"
                     /old_locus_tag="KI385_06755"
     CDS             11077..12240
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059133.1"
                     /locus_tag="KI385_RS06705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_06755"
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_238571292.1"
                     /transl_table=11
                     /translation="MPYTEASMNALRQDGDELADATVAALFERGEVGKFNTLMRYVSTV
                     GAPLPDGLPDIAREYLEATSAPPAWVDWGEMEKARMFFIDNNVHISTALSFASMPACYV
                     VPHVAKLLSATHGLKYPSKRMAETGQFTVYLMQPGAFEAGSRFIPAAQKVRLLHASIRH
                     HLTRENRWDAGALGVPICQEDMIGGQMFFSLLVLDSLHRLGIHMSTEGADAYYYVWRVV
                     GAMLGVNQDAVPKTLDEARQFLDLYMIRHMGPSEEGAHLTRQLIDLYEEIVPGTLFDPI
                     VSALIRHLVGDTCADWLKVPRTPWDTVVKAVPHLLGALETIEDRSPLGAWALDRLGHLT
                     SVLELSSLTRGRVMHYAIPEHLKKDYGVSSTPPRTRRWTPPTATVSQ"
     gene            12275..12961
                     /locus_tag="KI385_RS06710"
                     /old_locus_tag="KI385_06760"
     CDS             12275..12961
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS06710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_06760"
                     /product="hypothetical protein"
                     /protein_id="WP_238578089.1"
                     /transl_table=11
                     /translation="MRQSTVARAQDSLARRTTALGVFAAVAVTGTTSGLLLSGIMRNGR
                     VNWRLPLLMNVPLGLVVLAGTWGLVEAGRQRGRLDVWGAITGVGGMLALALGLSRAFRD
                     GWADTAVLTSIPAAIGLLVVFLIIQARTAHPLMPLRLYSDPRRSGSYVAMALCSALFSV
                     FNYFFQRSADPADYTSVFVRLLIASVAVTAIAGARLHRRYERKAEHFLAFTSIACTLIC
                     YRRLAK"
     misc_feature    complement(13109..13123)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.37"
                     /tool="antismash"
     gene            13231..14295
                     /locus_tag="KI385_RS06715"
                     /old_locus_tag="KI385_06765"
     CDS             13231..14295
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114940.1"
                     /locus_tag="KI385_RS06715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_06765"
                     /product="ferritin-like protein"
                     /protein_id="WP_238571293.1"
                     /transl_table=11
                     /translation="MTQVLEYESNAIVELMGVLPADRDAEWLKNSLQQAVMVELATIGP
                     YASAMWSIKQPGQTVYNDIREIIFDEMTHMGLVCNMLTTIGGTPVIADPKVVPKYEGPL
                     PGGVRPELTVFLEGLNKDSVEMFSEIERPDKPVAQFETFTTIGAFYTTIEDAFEVHQHL
                     IKGTRQIEYSLAHHGEGNNILPLDTIEKVRAAIEVIKEQGEGTSASPQNPFPGKPGELA
                     HFYVFREIFHGKKLIKTSESPDVWEFKGDDVPMPAAYPMGRVPQGGWANDELNAPSAEI
                     QKTLGEFNTEFSAMLRALDRAWRTDDPAEGKSEVSKAVGHMFAMSPKAKSLVQQELPDG
                     SGKTYGPEFLYVEE"
     misc_feature    14924..14934
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(15589..15604)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.17"
                     /tool="antismash"
     misc_feature    15766..15781
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.93"
                     /tool="antismash"
     gene            16040..>16321
                     /locus_tag="KI385_RS06720"
                     /old_locus_tag="KI385_06770"
                     /pseudo=""
     CDS             16040..>16321
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329534.1"
                     /locus_tag="KI385_RS06720"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="KI385_06770"
                     /product="SMI1/KNR4 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTETTGDDRRFHPALADMARVEFDYGDEGEGIDFEPCDAFDSVQE
                     TTDWLHHWTGNPEPDGSACRVFG"
     gene            16819..17166
                     /locus_tag="KI385_RS06725"
                     /old_locus_tag="KI385_06775"
     CDS             16819..17166
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236626.1"
                     /locus_tag="KI385_RS06725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_06775"
                     /product="CU044_2847 family protein"
                     /protein_id="WP_238571294.1"
                     /transl_table=11
                     /translation="MAALARIPLGGGGCILVEAPTALEGPVKAGRVSDAIHDLPGSLQG
                     ALEPVTAAARATLDQLRKAGPDEIAVEFGIDLAVEAGAVITKSGANCHLKVTMMWKRNR
                     PGHPGTDEGLD"
     misc_feature    17098..17100
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18936..18950)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     misc_feature    complement(20199..20208)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.9"
                     /tool="antismash"
ORIGIN
        1 cccactggcc gttcacccgc agcgccgtca acagcccgga cacggtgcgg cacggcaacg
       61 ggtcgtcggg gtggcgggtc agaggttcct tggcacccgc gccggtgatc agcacgacgg
      121 ggtcgctggt gcggtggaaa ggcggctcgg cgacgcggcg cagctccagg tcggcgggca
      181 gatggtggtc ggcggcgaaa cggtcgatcg cctcctgcac ctgttcggag gtggtgccct
      241 gcgggatgtg ctggcgcagg tcggtcagct cggcgatcag cgcagcggcg cgctcggccg
      301 gggtgccctc attgtccggt tcgagttgcc acgcggcggc ctcgtcgaag ccgtcggggt
      361 gctcgccggg caggcccttg agccaccaca gggtacgcaa ccgctcctgt acgtgggcga
      421 gttcgcgtcc ggccgcgtcg tggcggcgct ggtgctcgtt gagttcggcc agccacgacg
      481 gtgtgttcgt cggcgcggcg cgggcgggtt cggggctgtc ggtgggccgg ggcacgatct
      541 gccacgagta gccggacgcg gacgcggaga accaggcacg tcgggtgacc tcgtccaggt
      601 cgtggccccc gtccgcctga tcgaggccgt cgatcgtccc gtggtacagg gccttgatca
      661 gctccccggt acgggccgag cgcgactgga gtgcggcgat gtcgccgagc gcgtcggcgg
      721 tgctgtggcc gacggcgacc gggaggtcgt tgtggccggg catggcggac ggaggcgccc
      781 agttgtagta cgtccacggg atgccgagcg cggtgccggt gtagaccgag cgtcgcggac
      841 cgtcgccgac gggtgggtcc tggtcctcgg ggaggtcggt gtacccgggc agggcccagc
      901 gcagggcccg cagcaggtcg tcggtgcggt gtaggggcgg gaacacgccg ggattgtcat
      961 cactcggcgt ttcgggcggc agcaggccgg ggatgtcggc cgcccgccgg aggaactcgg
     1021 cggtgtcgtc ggagtaccag ccgatcacga agtagctcag ggtggtgggc gcgggcacgt
     1081 tgtggccgtc gcccttgagg tcgaggagcg tgtcgtggaa cgagaagacg ttctggtggt
     1141 agggctggaa gccggcgaac gcgggcaggc cggggccgat cgcggtgagg aagggctcga
     1201 cgggggcggg ttcgctccag ccgccttcgc gcaggtcgtg tgcgcggccg atccagtcct
     1261 cgcggagttc gccgtcctcg gggttctcgg acaggaaggg ggacgcgccg cgcttgccgg
     1321 ggacgccgtt cgtgaattcc aggtagtcac tgtggatcat ccatgccgcg gcccgggtct
     1381 gtccggctcc ggggcgcggg gagggcacgg tgtgatggcg gaccacgagc cagcggttgg
     1441 gcacgagggg gaaggtggtc tcgccggtgt cggggtcgta gtgaccggag gtgagtgcct
     1501 cgggcagttg ccactgcacg tgcacgccgg tcgcgatgcc ttcggtgtcc ttgctgggcg
     1561 cgggttcggc ggccgtcttg ttcgccagca ttttggcgaa gttgggctgc caccgcatga
     1621 aggcgttgcc ttccttgacg gtctcgttga ccaccagggc gtgcaactgg acggggacga
     1681 tcaggtcggg atcggtgtcc gtcatcgcgg gctcccggtt gtcgtggcgg tcgtggcttc
     1741 cgggaaggcg ggcggcttcg gcgcgaggcg ctggaggacc ggggagttga ccatttgcag
     1801 ggcgaactgc gacggagtga ggtcgtccag ctcgaacgcg gcggccaggc cggagaccag
     1861 gccggcgtcg ccgcacaggc gcagcacgtc cttggtcccg ccgtccgggc gatcgcgcag
     1921 gtatgtgcag aacaccgtgt ctgtgtccgg gtgatcggga gcggggaagg aggcgccggt
     1981 gtcctcgccc aacggggggt tcccggcgcc gccgaggctg cgcaggttga tccggtcgcc
     2041 ggcgtcgatg ccgaagtgga tgccctggcc gggttcgcgg atctcgatca cgtcggggac
     2101 gtcccggaag aggtacagga tgaggttggt ggccagccgg tcctggcgca gttcgacgat
     2161 gggtgtgccg tcggcggtct tcgcgacgag cgggaagtcc ggccatgctt tgaccagttc
     2221 ggagttgatc aacaggccgg caccgggccg cagttcggtc cgcctgctcc ggccgacgac
     2281 ggcgcgcagt tgcgggtcca ggtcgcggtc catcgaggtg tgcatgccga cgtcgctcgc
     2341 accggcgagc acggcgtcca gccactgctc gtcgatccgg aacatccgca tcgattcggg
     2401 tggcagcatg cgggggtcgg gtacgaggta gcagaacggg atgccacgca gcaggccgag
     2461 ttcgtcgagc caggccggca tgtcgccggt gttgcgctcg gcggtcgcgc gcagcagcga
     2521 catggaacgc tcctcggtga gcagcgcgcg gccctcggcc cggttgagcc ggcggcggcc
     2581 ggtcacccgc ggggtggggc ccggatcggc gcggtcggtg agcgcggcgg ccagcgatcg
     2641 gccgccgtca gcggcgagtt cgtgcagcgc ggcgagcccg cgaccggcat cggggtcggt
     2701 gcgggcgcgg accgggtcgg ctgccattgc gcgcagtgtg gcggcccggt tgccgagttc
     2761 gcggcgggca cgggtgatct gcgccgagta gtcggggtcg gcgagggcga tcgtgcgccc
     2821 cagcgtccac gcggtcgcgt agctgacgtc gaacaggccg ttctcacgtt cgtagatcag
     2881 cgcgtggtcg gccgtggtgt ggccgctctc gccggcctgg ccggggacgt ccggggtggt
     2941 gaccggggtg gcgggtcccc ggtaccaggc gtaggtgagt tcgccggaga gggtgcggaa
     3001 aggcaccggc gcgtagccga gtgcgagccg ggcccgggcg tagcgttccg cgtcgtcggc
     3061 gggttcaccc ttcggcgggt tgatccgcag cgcgaggtct tccgggtcgc cggaccagct
     3121 cggttcgacc aggtgctgga gcatgtccgg gatgtcgagc gcgtgggtga ggtcggtggt
     3181 gaacgaccac gaggacagcg acaccagacg cagcgcgcgg tgggtccctg gcgcgcccgg
     3241 ttccagttgc gcctcgtagc cttcgagcga gaccaggtgc gcggtatagc ggccggcctc
     3301 gcgcgggaag cggttggcgg tgaccaccgc gtacttgccc tcggtcagca cctccccttg
     3361 ggcgcccagc accgggcgga ccacgtcgcg cacgtgcgcg aggtagtaca tctcctcctg
     3421 gtacggcgcg acccggcgga agacctctcg ggggacgtcg atggtggcgc acttgctcgc
     3481 ggcgatgccg gaggtgatcc cgcggaggtt gctggggccg atcacgtcct gctcggtggg
     3541 cttgatcagt tcggcgacgg tgcgcagaac cgtgtccccg gccgccgccg ggtcgtcggg
     3601 cagttcgccc tcccggaaca ccagcagcgc gacccagggc gcgcgagcgc gcgagcggac
     3661 gccggtgagc gagcgttccc acggcaggat cgcccgatcg agggtgatgt gcggcagcac
     3721 cgcgtcgtag cgaccgctcg ttccggcggg tgggtagtag gcgtgcacgg acgtctcgtg
     3781 cagggtgaac cgggccgcgc ggacctcgaa cttctgctcg gcggccggca gcggatcggt
     3841 gtcgacgcgg gtgccgtccg cctccttgag aaggtgttcg gcgtgcacgg tgtatacgcc
     3901 ggggtccgca cgggggacga ggtagtcgtg gaaggtgacg tcgagtcggg gcggttcgtt
     3961 ctgccggaag gcatcgggca cgcggctcac ctcgctgcga tcggggtgga catggcgggt
     4021 gcggccgtgg tcagcggggc gtcggtcatg ctgcggccga ccaggcgggc gtagtcggtc
     4081 agcgcaccgt cggtgtcctt gccgggggcg gcgcctaggc gggtcaacgc gtcgtacacg
     4141 gcactgcggc gagtcgccgt ggtaggggag gcgagcgttt cgacgatgac gccgacgctg
     4201 tccggatcga cgccgggctc cgggccctgg gagtcggctt cgcgcagggg cgtgtagccc
     4261 tcgggctgcg gttcgacgcc gagtgcggcc gaggtgaccg ggccgaggcc ggggcccagg
     4321 tcgggaccag gaacctcgaa gtgcagcccg gtgaacaggc ccggttcgag gccgggttcc
     4381 ttgggcgagg gcttggtcac cggtttgccc cacagcgctc ggggcaggtc gcggcggatg
     4441 acagtgcggg tccacaggtt ggggtcgggg gtgtactcca caccgtcgag gtcgagcgtg
     4501 acgatgtgtt cggaggtcag gccggtcttg cccatcggcc ggatgtcgat cttgttgtgg
     4561 gcggtcgcga tggcctggcc gttgagccgg atcacggacg ccggcagtgc tgcctcggtg
     4621 gagaacgcga acccgtcgga ggagaccagg agcggcgcct gctcggcctc gcgcgcctgc
     4681 ctttcggact tgtcgacgtc gaggagcagg cccttttccg gcttggcccg gatcggcgag
     4741 ggcagctgca tctggaactc gctccacggc acgggtggtg cgcccttgcg ggaggagccg
     4801 aagtcgaagc cgaaggagat gaaccagacc ttgacggtga cgtggccccc cagcggcggg
     4861 gtccacagtt gcaggtcgat gccgacctcg atggagaccc ggatcttgac gatcaccttg
     4921 atggtgaacg cgacgccgat cgagacgccc atcgcgatgt cgaggtagaa cggcttccat
     4981 tggatcaggg cgtccaggtg cgcggtgaac cacgcgctga gcaggcccct ctcgtagcgg
     5041 gcggcgagcg cgccgccgaa catgatcgcg ccgggggtga gcgcggtgta cccctgggcc
     5101 tggatcacca cccggccgca cgggttccac cggaacccga gccgggcggg cctggggtag
     5161 tagtcgggga gcgcgaactg cgggtggtag ccgccgatgc tgatcacgaa gtcgccgccg
     5221 cgccccccgc cggtccacac gcacagcgcg atcccaccgg tcagctcgca cgccgggtcg
     5281 aagaagaacg agccgggcgc gaccgcgacg tcgaggctga tcagatgctc gtcggagagg
     5341 tacgccaggc gcaggtcgat gttgaggcgc gcgtgcaccc ggccgccgac atcggcgttc
     5401 ttggggaaag tgacggacgt gcggccgagc aacatcaggt tgagccggtt gccgaactcg
     5461 acgagcgcga gcgccttggt ctcgatgaag cggaacgacg tgaaccgcac gccgatcgcc
     5521 gcccagtacg agccgtcctc gggccggacc caccccgcct tgccggcgag gttttcgagc
     5581 atgtccatcg gcgtcggcgg gtcgggcgtg gggtccgcgg gtgtcggtgg agcctcgtcc
     5641 agtcgggaga ccagcgggaa ggcgggcagt tgggccgcgg tgggcggccg gatggtgctg
     5701 ttgatgccga aaccggcgga caacccggtg acggtgaacg gcgacggccc gaacagcgac
     5761 cgggcctccc tcgcgagcag ggcctcgacg tacaggaaca ccgagttgaa gccttcggtg
     5821 gcgcggaaga acccgcccgc gcccaggact tcgaccgcgg gcgtggtcac ccgcacgaga
     5881 ccgaccagcc cgccggcgat gcccgggtcc ctggcgccgg cccagcgcat cgcggccatg
     5941 atctgcatgg gcggcttgac gcgggtgatg tcgagggctg cgcccatgag ttccggcttg
     6001 gggatgaagc cccccgcgag cgggacgacg atgccgagac cgtcgagctg gaacgtgaag
     6061 cccgcgaggc ggaactcgcc gaccaggaag atccgtaacc ccttcttctc gtcgaaggaa
     6121 cgccggacgg cggcgatctc gaccgggccg aagctgaccg gcagaccggg tacccggatg
     6181 tccttgtccg gctcggacgg cttgtctttc tcctccttgt ccatcgagat cgccagggcg
     6241 ggcagctctc cgccgttgac ccaccagctc actacggcgc tgaacttctt gggccacgcg
     6301 tgctcggtca tcacgttcgg gagcgggaac gtcggctcgg tgacgccgga cccgcacagc
     6361 accctgttga gttggttcac ctcgtccacg acgatcgcgc gggacatgta gacgatccgc
     6421 acggtcggga agacgaacgc gcccgtgggg atgctctcgc cgaccaggct cagaccggag
     6481 gcgtcgaaac cgatccggat gtcgagtacg gccgcgctca gcgaggcgtt cccgaccttg
     6541 ttggtcttga cgaacagcag gtccacgggg ctggcttcgc cgggctggtc gtaacccggc
     6601 gagcgcgcgg tgtacagctt ctcgccggtc ggcaggccgg tgtgctcgac cacgttctcc
     6661 aggtacggga ccagttcgtc ggggagttcg accatcggtt ggtcgatggc gttgaacatg
     6721 tcgagcaggg tgacttgttc ggcggcaggg gacacggggc ctcctcggcg ggcggggcgg
     6781 gtggggcgcc ggtcgcggcg tggtcagtag atggtgaagg cgacggcgcc cggcccgatt
     6841 ttcagggtca tcggcatcgt ccgatccagt acgtgctcat cggtgtcgat gaccgaaacc
     6901 gaaatcgact cgggatcgcc gacgaaggcg tacgttccgg caaagtcgaa cgcgatcccc
     6961 cgagggctgc cgaggccgcc ttgagcgctg accgggatcc gatggcgcac gcggtgatcg
     7021 accggatcgg ccaccaggac accggacttc tcggcgtcgg gcaggcagta caacgactgc
     7081 ccatcgggcg tcagcgcgac gttccggcag tgcggcagga cacccctgca tcggatgctc
     7141 ccgttgcgca catcgaccgt cacgacgtcg gtctgcgttg ccacgtgcac gaagagaccg
     7201 tccgaagaga tggccaggtc ctcaaacttg gtggaattgg ggatccggaa ggcttggcgg
     7261 acccggctcg cctcgtcgtc gacctcgatc accacggcgt ccccgtcgag tgagccgccg
     7321 aagtagaggt accgaccacc cggcgcggtg aggatgggtg tgtcccacag ggccaggccg
     7381 ccggtctcgg cggcctcggc cgggtcgtcg aacaagtcgg tgccacggac ctcgatgcgc
     7441 cgcgtccgct cggcggtacc gacgcgaaac gtgtccaggt ggaagaccga cgggtcgaac
     7501 gtgcggatga tgccgtggat gtgcagcccg tctggactga atcccacgtt gctggaggcg
     7561 tatgtgtcct ccgtcaccgg agtctcggcg aggaggaggt tgctggtcgt gtcgaaacac
     7621 atccaggtgg aaaccgaccg gatgtacacg tagcgaccgt ccgggctgac ggcgatcgcg
     7681 tgccgagtga ggtagctgcc cctcactttg tgactgaagg tcacctttcc ggtttccacg
     7741 tcgacgctct cgacggtgct gtggttggcg tagccgtcct gggcgtagac gtgtccgcgg
     7801 gcgaacgtcg ggaccaggcc cggccacgaa ctctcgtcga ccacggccgc atcggtcgtc
     7861 acggtgcggg tggccaggac gcccttggcg tagtgcgcgc cccggaagag gtggaactcg
     7921 cctttgctcg gatcgtacgt cgccgcgctg atcccgttca cgaactccgg ggccttggcc
     7981 tgcaggccgg gccacatctc cgcgagcgtc ttcgtctcga ccacggcgtg ggcccgcatg
     8041 tcgtagagaa cgcactgatt cccgcggaac aggaacgcct gattcccact cgatcccggc
     8101 agcgccgcgt cgaccccgga cgcgaacacc gccggcaacc ccgggaaccg cgccgcgatc
     8161 gtggtgacct ccgcgaccgt ctcgtccaac gggtgcagtc gcaggcactg cgtcccgcgg
     8221 aagacgatgg tccacgggtc gtccaacggt gtcgtcaagg tcgcgtcgaa gccagaccgg
     8281 aaggccgcgg ggaggtcggg ccaccggcgc gcgagcgcca acgccccgtc cagcatccgg
     8341 tggctccccc agccgaaccg ggccgcgcgg tccccttgga ccacgaatcc ggtctgttcg
     8401 gccccctgac cggcgttggc tgtcgtgaag aatgcgtcca cttggtgctc gggcatgagg
     8461 gtccttctgt gcgggtcggt tggagacggt tgtggtggca ccgatgcgtc atcagcgggt
     8521 gtaggcgagg tcagcggcga tggccgaccg ggtcagccac cgggacaccg gagttgctaa
     8581 tcgcgggcgg acacggtggt tcgcgatgat cgaggcgcaa cgcgatcgtg gtatctgtgg
     8641 gcaacgtgcc gcggagcgtg accccgccgg accggcctcg gcccggcagg gcgaaagttc
     8701 ggcgcagaac gttctcgtcg aggtcgactt cgtcgaccat cggcgaatcg tccgctgtct
     8761 ccgccgcgcc tgtgtgggcc tgggcatgcc gaattccggt cgacaccacc gggaacggat
     8821 cgagtcttcc cccgacttcc ggccgacatc cgtctcggat gaaataccaa ggtgttccac
     8881 ctcgaaattc gcgccgggac ccgccggatg gtgaaagcta tgcgtaccgg caccggggac
     8941 gtagaagcgg tggtggcggc cagcccggcg acccacaaca ccctcgcatc gccctccgca
     9001 ccatcaaccc gcagcgcgtc gccacgaaac accaggcccg cgtcgggcgc gtggtcaccc
     9061 ggcacagatg ccgggatctt gaccactccc cacggcgctg cctgctcaag gatttcccgg
     9121 atctcaccca cacgtacggc cacagagcct cagcttccga accacagcag aagggaaaac
     9181 agcccaaata ctcgccttta agatgcagga gcctcacatg cccggcatcg agccttgcca
     9241 actgttgccg gtgcgtgacc gcagcgcaat catgcgtgac caacacgcca agatagcccg
     9301 ccattttccg ccaacgggcc cgcaggcaac atctgccact gccgccgcag caggaagaca
     9361 cacgcgacgc gtgcgccggc ctctcggcac agaaggcggc gaccaggtga cgatgtactc
     9421 gtcgccgtcg ccgggaagga agccgatagc cgcggccggg tagcccgggg gcatctcctc
     9481 gtccgatgcc tcacggatcg ccggcttggt gtcgaccgcc agggtgaggc gggtgccgtc
     9541 ggtgacgagg tcgaggttca tggcgtcgat ctcgtaacgg ccgacgacgg gccgcgacaa
     9601 cagtccgtca tacattcgag cgatgtgatc actcgttggt gagtttttat gctctggtgc
     9661 cctgtctggc gcgacgctgg gaagagcggc gcgggacgac gccgctcgga cgcgctgtgg
     9721 gtgggggatg gcatgacgcg agatacggga gcccgcgagg gcctggacgg gcaggcgatg
     9781 ctgctggcgg cggggctggc ggatctggcg gtgagcacgc tgggttcggc tttcggggcc
     9841 gtgcgggggc tgttgaggcg ttcggacgcc gccgagcttg cagcggaggc cgagcaggat
     9901 ctggtggcgc gcgggcgcct cgtgctcgac cggtatgcgt ccgcaccccc ggcccacctg
     9961 gaggttctcg cccagcacgt gctggcccga cgggccgacg atggcgtctg agcggtggga
    10021 gccgaccgcg ttcaaggcgc gcgtcgatga ggtgctccag cgtttcgtcg cccgggagac
    10081 cgaccagctg tcggcgatcg ccccggcctt gaacccggtg gcgggacaag tggaggcagc
    10141 ggtcgcggac ggcaaacggc tgcgggcggc gttctgctac tggggctggc gcgcggtggg
    10201 gcagccggac agcgacgcgc tggtgcgggc ggcggcctcc atggagctgg tgcacgcggc
    10261 cgcggtcgtg cacgacgacc tcatcgacga cagcccgctg cggcacggac ggcccaccgc
    10321 acacgtggcc ctgcgcggcg ccgtggagca ccacccgcgg gccgctgcgg ccgcccggtc
    10381 gctggcgatg ctggtcggcg atctgctgat gtcgctcgcc gggcagttgt tcgtcaccag
    10441 cggcctgccc gccgcctacc tcggccgggc ccgcccactg tgggcggcgc tcgcccggga
    10501 cctgatcgcg ggcgagtgcc tggagatcct tcacaccggt gccgccccgg acacggcggc
    10561 atcgctgaag gtcatccgct acaagaccgc caagtacacc gtcgagcagc ccctgttgat
    10621 cggtggcacc ctggccgggg ccggcgagcg gatgcgcgag ggatactccg cgtacgggct
    10681 gccgctgggc gaggcgttcc agctgaggga cgacctgctc ggcgtgttcg gagatccgga
    10741 gctcaccggc aagtccggcg ccgacgacgt gcgtggccat cggcccaccg ccctgctcgc
    10801 ggagacctgg cggctcgccg gggacaacga gcgcgagcgg ctgcgcgccc tgctcggcca
    10861 acgcgacccg gacggggacg gtctggaggc cgtacgcgag gtgatgcgcc gactgaaggc
    10921 gcccgaccgc atcgagaaca tgatcaccgc gcgggtcgag gaggccctct gcgctctcga
    10981 cgagctgact ctgcccgcgc ccgccgccgc cgcgctcacc gccctggcgc actcggcagc
    11041 ggtccgccgt tcctgatgga gacaaggagc cctgccatgc cctacaccga ggcatcgatg
    11101 aacgccctac ggcaggacgg cgacgaactc gccgacgcca cggtcgccgc cctcttcgag
    11161 cgcggggagg tgggcaagtt caacaccctg atgcggtacg tctccaccgt cggcgctccc
    11221 cttccggacg ggctgcccga cattgcccgg gagtacctgg aggccacgag cgccccgccg
    11281 gcctgggtgg actgggggga gatggagaag gcccggatgt tcttcatcga caacaacgtg
    11341 cacatctcca ccgcgctgtc ctttgcctct atgcccgcct gttacgtcgt cccgcacgtg
    11401 gcgaagctgc tgtcggcgac gcacggtctg aaatacccgt ccaaacgtat ggcggagacc
    11461 ggccaattca ccgtctacct gatgcagccc ggcgcctttg aggccggcag ccgcttcatc
    11521 ccggccgcgc agaaggtccg cctgctgcac gcctccatcc gccaccacct cacgcgcgag
    11581 aaccgctggg acgccggagc gttgggggtg ccgatctgtc aggaggacat gatcggcggg
    11641 cagatgttct tctcgctgct cgtcctggac agcctgcacc gcctcggcat ccacatgtcc
    11701 acggaggggg cggacgccta ttactacgtg tggcgcgtgg tcggcgccat gctcggcgtc
    11761 aaccaggacg ccgtccccaa gaccctcgac gaggcccgcc agttcctcga tctgtacatg
    11821 atccggcaca tgggtccgtc cgaggaaggc gcgcacctga cccggcagtt gatcgacctc
    11881 tacgaggaga tcgtgcccgg caccctcttc gacccgatcg tctccgcact catccgccac
    11941 ctcgtcggcg acacctgcgc cgactggctg aaggtacccc gcaccccctg ggacaccgtc
    12001 gtcaaggccg tcccccacct cctcggcgcc ctggagacca tcgaggaccg ctccccgctc
    12061 ggcgcctggg ccctggaccg cctcggccac ctcaccagcg tcctcgaact gtcctccctc
    12121 acccgcggac gcgtcatgca ctacgccatc cccgaacacc tcaagaagga ctacggcgtc
    12181 tcgtccacgc cacctcgcac ccgccgatgg accccaccaa ccgccacagt ttcccagtga
    12241 tccacgtgct caggattcgg tgacacgaac tcgcatgcgt caaagcacgg tggcacgcgc
    12301 tcaagattcg ctggcacggc gcaccaccgc gctgggcgtc ttcgcggccg tggccgtaac
    12361 aggaactacg agcggcctat tgctcagcgg aatcatgcgc aacggccgtg tgaactggcg
    12421 gctgccgctc ctcatgaatg tccccctcgg tctcgttgtc ctggccggca cctggggcct
    12481 ggtcgaggcg gggcgacagc gcgggcggct ggatgtgtgg ggagcgatca ccggagtcgg
    12541 cggcatgctc gccttggcac tcgggctttc ccgcgccttt cgcgatggct gggccgatac
    12601 agccgtcctc acttcgatcc ctgcagcgat cggactgctc gtcgtctttc tgatcattca
    12661 ggcacggact gcgcatccgt tgatgccgct gcgtctgtac agtgaccctc gccgttctgg
    12721 cagttacgtg gcgatggcac tctgcagcgc tctcttttca gtcttcaatt atttctttca
    12781 gcgttccgcg gaccccgctg actacacatc ggtgttcgtc cggctactga tcgccagcgt
    12841 ggcagtgacc gcgattgccg gggccagact gcaccgtcgc tacgagcgca aagccgagca
    12901 cttcctggcc ttcaccagca tcgcctgcac cctcatctgc taccgcagac tcgccaaatg
    12961 agatggcgtt ttaagcaaga tcatcgatct tggagcggcc gtgctgcagc tgccgtgtca
    13021 gaggcaggcc gggaatcacg gtcgcgattc gatgatcgaa tgaggtgacc atcagcgcca
    13081 cgccctcaat cggatgaaca atcccctgag ttctcagaca aatgacctgc cgtaccggga
    13141 gggaccagta gatttccacc atcggccatc gagtggatgg catggcatat gtgcattcgg
    13201 tccgtatgcg taatttcaga agggcacgcc atgacccagg tcctcgaata cgagagcaac
    13261 gccatcgtcg agctgatggg agtcctcccc gcggaccgcg acgcggagtg gctgaagaac
    13321 tccctgcaac aggcagtcat ggtcgagctc gcgaccatcg gcccctacgc cagtgccatg
    13381 tggtcgatca agcagcccgg ccagacggtc tacaacgaca tccgcgagat catcttcgac
    13441 gagatgaccc acatggggct ggtgtgcaac atgctcacca ccatcggcgg gactccggtc
    13501 atcgccgacc ccaaggtcgt cccgaagtac gaaggcccgc tgcccggcgg cgtgcggccc
    13561 gagctgaccg tcttcctgga gggcctgaac aaggactccg tcgagatgtt ctcggagatc
    13621 gagcgaccgg acaaaccggt cgcgcagttc gagaccttca ccacgatcgg ggctttctac
    13681 accacgatcg aggatgcctt cgaggtgcac cagcacctga tcaagggcac ccggcagatc
    13741 gagtactccc tggcgcacca cggcgagggc aacaacatcc tcccgctcga caccatcgag
    13801 aaggtccggg ccgccatcga ggtcatcaag gagcagggcg aaggcacctc cgcctccccc
    13861 cagaacccct tccccggaaa gccgggcgag ctggcgcact tctacgtgtt ccgggagatt
    13921 ttccacggca agaagctgat caagacctcc gagtccccgg acgtctggga attcaagggc
    13981 gacgacgtcc ccatgcctgc ggcctacccg atggggaggg tcccccaggg cggttgggcc
    14041 aacgacgagc tgaacgcgcc ctcggccgag atccagaaga cgctcggtga gttcaacacc
    14101 gagttcagcg cgatgctgcg agccctggac cgggcctggc ggacggacga cccggccgag
    14161 ggcaagagcg aggtgagcaa ggcggtcggc catatgttcg ccatgagccc gaaggcgaag
    14221 tccctcgtgc agcaggagct gcccgacggc agcgggaaga cctacggacc ggaattcctg
    14281 tacgtcgagg agtgagcgga cccggctcgg cgtcgggagc agggctctcg ccttggtggc
    14341 ggacagcttg gctcccgagg tcagggtgac gtggtggctg gtgcggaccg cgaccgcgta
    14401 gccgaggctg agccggcggc aggtggtccg cagggccttg gcgccgtaga cctcgtcgcc
    14461 ggtgaagaag ctcgcgcgga ccccggcggc gtgcgccttg tgcagcatgg cctgggtctg
    14521 ggcggtcttg cctcttcacg gatggtgtcc cgccaagtgg tgttagggga tcaaggcgcg
    14581 aagccacagg tcaccccaag gctgaatgat gcgcgacggg ccgtgtccac ggcgcgccat
    14641 cccagctagg gcctacctct tcgatatttg ctggcgcgca tcgcccacaa cgcacgtgcc
    14701 gcacaagcca aaaaccgcaa gtcttaagcc ctttgcggca ggttcaagga cggaaacgca
    14761 ctccacatga cgcgtcatcg agaaaagacc gatgactcgc atccgactcg acgcatgccc
    14821 cgcctcgccg ctgcactcaa gtcgcgggag tggccgggct acgggagcgg tgcgccggag
    14881 gtgggaccga cgtcaatgac gtcggcgcgg ggaggatccg ttcggcaatg tcacctcgga
    14941 gaccgccgca gaccacctgc aagtccagcg gtatccagcc tcgtcgcccg acggttcccg
    15001 ccgtccacta atcgctaccg ccatccccat tgagagcggg accacgatcg agatgggcac
    15061 ataagcccct ccgccagcac gacgcttctg ttgcgccacc ccagcacgtc atcctcagcc
    15121 atcgtgcctc agacggtatt tccccgacac cgaacaatcc ctcagggaag gcgtttacat
    15181 cggcgtcaac tgctgaaatc gagccctctc aaccgcacgg ggcctccgag gcggcccgct
    15241 ccccgattca aggcacaggg ccatcgaagt gacacgtcat cagatttagc tgacgaagcg
    15301 ttagcaaagt cagcgttgag tcagcatgcg tcctgccaga ggtggtgaca ggtgacgaca
    15361 catgcacatg cgccgatctg ctctgcacca cctctgagct gcaaagatgc tggccaaccc
    15421 gctacaccac caacgttgcc ccaaacccgg taccaatgga agccgaagag gtacggcacg
    15481 acatcgttgc aggtcagggg catttcaagg tcagcaagtc agcacaaagt cagcatcggc
    15541 ggcgccacgc cgggaaacga gccgactccc aggggtcatg cggcacgccg tggtccagac
    15601 ctccgcagac gtccgaggtc gagacccgat gccagttgtc gcaccacaca gtacaaccgc
    15661 cctgcattta gcgttgatgg tgctcgcctt ggggccactt tgttcggctt ccgaaatcgc
    15721 tcacggcgcc gccgtcgtcc cgccgcgtga agtcggacga tgctcatgac cgactgctcc
    15781 gcccacaccg atgcaggcgc tgcaggaggc aggtggaggt gagtgatacc tcgtcagttc
    15841 cactcgcgag cagctgcgcg cgtggcgtgc tagacgctcc ttcggcctgc tgggccggat
    15901 gctcgcgggc gtctcactca cgggtgagaa gccaccacaa cttgcccaga atcagttgca
    15961 gttcctcgat gcaccagaac gcgaggcccc tgagacgtac gcggccagct tcctcgcagc
    16021 agctacgtag cctgcgaaga tgaccgagac gaccggtgac gaccgccgct ttcatcccgc
    16081 cctagccgat atggcccgag tggagttcga ctacggcgac gaaggcgagg gcatcgactt
    16141 cgagccatgc gacgccttcg actccgttca ggagaccacc gactggctgc accactggac
    16201 cggcaatccc gagcccgacg gcagcgcctg ccgagtcttc gggtaggacg gcgccggcgg
    16261 tctcggcgcc ctctggtacg cgcggccggg gcagcccctc accgagcagc ccgtggtgtt
    16321 cccgagattg tctccttgga cgatccccgg gagcgacccg ctctcacgca acggcgtaca
    16381 ccaccgtccg tctgtgccct ggggagaatc cggggagatt ccgctcggcc ccgccacccc
    16441 gccgccagcg ggtcatcgaa ggccagacgc cccggtatat ggcgcgatca tccaagctcc
    16501 gcccgggcag cgactttcgt ccggcgcggc caggacggcc caaggaaaga cgtcatgacg
    16561 tacctggcca aggaagcagg cgccctcgac cagacacacg accaagatgc cggacaagga
    16621 gccgcatctc atctccaacg aggcgcaggt cagagcatct cattcgtaca gcccatccca
    16681 aggtgcggca tatgccagat tcgttgatgc tggctgggac tccgtagggg ccatccgcgg
    16741 ccatcgatcg catccgctgg tggacggcac ccagctcgtc agcgcctgca acgagcacga
    16801 acgagcgaag gaggagtttt ggcagcgctg gctcggattc cattgggtgg cgggggctgc
    16861 attctggtcg aggctccgac tgcgttggag gggccggtga aggccggtcg cgtcagtgat
    16921 gccattcatg acctgccggg gagtctgcag ggggctctgg agccggtcac ggcggcggcg
    16981 cgcgccacac tcgaccaact gcgcaaggcc ggccctgacg agatcgcggt cgagttcggt
    17041 atcgatctgg cggtcgaggc cggggccgtg atcaccaaga gcggcgccaa ttgccactta
    17101 aaggtaacca tgatgtggaa gaggaatcgt cccggccatc cgggcacaga cgagggtttg
    17161 gactgatccg gtggagatag ctggcagagg cccggaaagt gaccatgcgt cgggatttct
    17221 ttacggcgtg agccagatcc ttgggccaaa tgatgaggtg gttggggcgg gctttctgct
    17281 ctccgaggac gttctggtca cctgtgcgca tgtcgtgcgt ggggccgggg ccgggcccgg
    17341 tgaaagcgtg cagctggctt tcccccacgt ggctggtgcg ccccaggttg agggacatgt
    17401 cctggaggag ccgtggcgtt cccccgagga cgacgacgtg gccattgtgc gcctgagcag
    17461 tactgcagcg ggaatggagg gattgccgtt gggctctgcg gcaggctgcc gggggcatca
    17521 ggtgcgctcg ttcgggttcc ccgctcaggc cccgcctggc gggcacttcg gcttcggggt
    17581 gaccggcgat ctgctgccgg ccaccgatag caggggtaca catctgcagt tgacttccgc
    17641 caacgacctg accaccgggt tcagtggcgg gccggttgtc gacgaggtga cgggcctggt
    17701 catcggcatg ctcaccgaga tcaccgcccc ggatgagcac gaaagggggc aaggcattgc
    17761 ctatgtcacg cctacgcagg tactgcggga ggtctggccc gaactggtcg agcaggaggt
    17821 gtgcccctac cggggactgg agccgttcac cgcagagcag gcccagtggt tcgaaggccg
    17881 ggaagacgca gtgcggcagg tgctggcgaa ccttgcccag cagcagcggc tgacgctgct
    17941 gctggggcct tccggttcag gcaagtcctc cctggtcgaa gcaggtgtcc tgcctgcgct
    18001 ggccgcaggt gaactgccgg gcagcgaccg gtggttgcct gtgctcgccc gaccgaggca
    18061 ggacctgctg gccgaactcg agcgcgctgg gctatccggg gccaccacgg aggggatcac
    18121 cgcagccgtc actcgcaaac ttgcggccga accctcctac cagcgtgtca tcctgatcat
    18181 tgatcagttc gaagagctcc tcacccagcc caccaccggc ccgaaacgcg agcgccgctt
    18241 ggccgccacg gaccagatca ccaccgcggt caactcccac gtcgagctca gcgtgatcct
    18301 gatcatgcgt gacgacttct acccccaact ggcggctctg gcccgaatgt tggaggcggc
    18361 gatcccagga ctcctcaacg tgccaggtgc gctgagccag cgcgatctgc acgacatcat
    18421 caccctgccc gcccaggaca tgggagctca cttcgagcac gggctgcctg agcaaatcat
    18481 cagcgatgtc ctagccatca cacccgatgg ggccgcatcc ggccaggcac ccgtcaccgt
    18541 gctgcctctg ctggagctga cactcagcca gctttggcaa aggcgccagg acggatatct
    18601 cacccatgac gcctaccggc gcattggcgg agtcaccggc agcctgacga cctggtgcga
    18661 caccgccctc aaccacctgc cccccgagca cctacccatc gcacagcgga ttctgacttc
    18721 cctggtgcgc cccgctgacc cccgccacca cattcccgcc atccgcgagc aggtctccct
    18781 gcaagacctg cgcgacctgg cagccgaccc cgacgccgtg cctaacggcg acagtgccac
    18841 cgacgaggtg ctggctgccc tcactcgcca tcgcatcatc actacccaca caccccgcac
    18901 tcctggacgc cccgacaccc ctgccgggca gccggtggcc gaactgatcc atgacgccct
    18961 catccgggac tggggcatgc tgcgcgagtg ggtcagccag gaccaccgtt tccaggaatg
    19021 gctcgaccgc acccgtgaac ggcgcgcacg ctgggctcaa gggaccgacc ctggggacct
    19081 cctcggggga acagcacttg cagagggcct cgaatggtca caacaacgcc gcctaccggg
    19141 cgacatcgca gccttcctca ccacgagcca gcagcaccaa caggccgtca tccgacgcag
    19201 caggcacctc aacatgatcc tggccagcct gctcgttgtc gcgctcctcg ccgctggagg
    19261 agctctctgg cagtggcgga cagccgtcgg ccaacgtcaa gaagccttgt cgcgtcagct
    19321 tgccgcccag tccggcacgc ttatcagtgc aagtcccgat cttgcttcgc tgctggccat
    19381 ccaggcatat cgcaccagcc ccacccccga atccgtcgaa agcctgcaaa acgccgcagc
    19441 cctcccgctg cagcggcacc tgtccggcca caccggcacg gtggagtcgg tggcgttcag
    19501 tcctgacggg cgcaccctcg ccaccggcag cgacgaccac tctgtccggc tgtgggatat
    19561 ggccaccggc aagagacgga ccgtcctgac cggccacacc aacgcagtgg actcggtagc
    19621 gttcagcccc gacgggcaca ccctcgccac cggcagcgac gacggcacgg tgcggctgca
    19681 agacatggcc accggcaagg accgcaccgc cctgaccgac cacgcggact ggcggaactc
    19741 ggtggcgttc ggccctgacg ggcgaaccct cgccaccggc agcaccgacg actcctggca
    19801 gttgttggac gtggccgacg gcaagaaaca cactcccctg accggccaca ctggaatggt
    19861 ggactcggtg gcgttcagcc ctgacgggca caccctcgcc accggaaacg acgacggcac
    19921 cacgcagctg tgggacgtag ccaccggaaa gaaacgcacc accctgacag gccacaccga
    19981 tgcggtgtac tcggtagcgt tcagccctga cgggcacacc ctcgccaccg gaaacgacga
    20041 cggcaccacg cagctgtggg acgtagccac cggaaagaaa cgcaccaccc tgacaggcca
    20101 caccgatgcg gtgtactcgg tagcgttcag ccccgacggg cacaccctcg ccaccggcag
    20161 cgccgacaac accacgcagc tgtgggacgt agccaccggc aaaaaacgca ccaccctgac
    20221 aggccacacc gatacggtgt actcggtagc gttcagccat gacgggcaca ccctcgccac
    20281 cggcagcaaa gacaagtcgg tgcggctgtg ggacgtggcc ggcaagaacc gcaccaccct
    20341 gacggaccac accaacgcgg tggacgcggt ggcgttcagt cccgacgggc gcgccctcgc
    20401 cgccggcagc gacaacggcg ccgtgcgact gtgggatgcg gccaccggca agaagcgcac
    20461 caccctgaca ggccacaccg atacggtgta ctcggtggcg ttcagtcccg acgggcgcac
    20521 cctcgccacc agcagtgccg accacaccgt gcgactgtgg gacgcggcca ccggcaagaa
    20581 acgcaccacc ctgacaggcc acaccgatac ggtgtactcg gtagcgttca gccccgacgg
    20641 gcacaccctc gccaccggca gccgcgacgc taccgtgcgg ctgtgggacg tggccaccgg
    20701 aaagaaacgc accaccctga caggccacac cgatgcggtg agctcggtgg cgttcagccc
    20761 cgacgggcac accgtcgcca ccggcagcac cgacgacgtc gtgcgattgt gggatgtggc
    20821 gagcggtaag gaacgcacca ccctgaccgg ccatgctgga ccggtgggct cggtggcgtt
    20881 cagccccgac gggcacaccc tcgccaccgg cagcaccgac cacaccgcgc ggctgtggga
    20941 catggctacc agcgggaccc gtgccaccct gaccggccac accgccgagg tgtggtgggt
    21001 ggcgttcagt cccgacggga gcaccctcgc caccggcagc gccgacaaca ccgtgc
//
