LOCUS       NZ_CP084681            22526 bp    DNA     linear   CON 30-APR-2024
DEFINITION  Streptomyces inhibens strain NRRL30439 chromosome, complete genome.
ACCESSION   NZ_CP084681
VERSION     NZ_CP084681.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces inhibens
  ORGANISM  Streptomyces inhibens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Gillane,R., Talbo,G.H., Plan,M., Palfreyman,R.,
            Haber-Stuk,A.K., Power,J., Nielsen,L.K. and Marcellin,E.
  TITLE     Multi-omic characterisation of Streptomyces hygroscopicus NRRL
            30439: detailed assessment of its secondary metabolic potential
  JOURNAL   Mol Omics 18 (3), 226-236 (2022)
   PUBMED   34989730
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Palfreyman,R. and Marcellin,E.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2021) EMS, Australian Institute for Bioengineering
            and Nanotechnology, Cnr College Rd & Cooper Rd, Brisbane, Queensland
            4103, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. APRIL-2018
            Assembly Name                     :: AIBN_shyg
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 239.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022221585.1-RS_2024_04_30
            Annotation Date                   :: 04/30/2024 04:58:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,775
            CDSs (total)                      :: 8,682
            Genes (coding)                    :: 8,305
            CDSs (with protein)               :: 8,305
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 377
            CDSs (without protein)            :: 377
            Pseudo Genes (ambiguous residues) :: 0 of 377
            Pseudo Genes (frameshifted)       :: 158 of 377
            Pseudo Genes (incomplete)         :: 310 of 377
            Pseudo Genes (internal stop)      :: 38 of 377
            Pseudo Genes (multiple problems)  :: 116 of 377
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:32:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 984754
            Orig. end                         :: 1007280
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084681.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Australian Institute for
            Bioengineering and Nanotechnology, Building 75,Cnr College Rd &
            Cooper Rd, Brisbane City QLD 4072.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22526
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="deazapurine"
                     /region_number="8"
                     /rules="(GTP_cyclohydroI and PTPS and QueE and QueC and not
                     (dpdA1 or bTGT))"
                     /tool="antismash"
     cand_cluster    1..22526
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /kind="single"
                     /product="deazapurine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22526
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:12526](+)"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12526
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
     misc_feature    210..230
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.53"
                     /tool="antismash"
     gene            227..>628
                     /locus_tag="KI385_RS04700"
                     /old_locus_tag="KI385_04735"
                     /pseudo=""
     CDS             227..>628
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025217.4"
                     /locus_tag="KI385_RS04700"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04735"
                     /product="class I SAM-dependent methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNPEFHSQVADKFGGYSSGAQRTEVFPDGDPEDALDGLAIGLVHT
                     GARLVDVGCADGRNVLRVAPAFTSVLGIDLSMPMLESAGRHRETSGLDHVEFELRDASG
                     TGLPDGDVDVITSRRGPLFPDEFRRILKPG"
     misc_feature    329..331
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            875..>1273
                     /locus_tag="KI385_RS04705"
                     /old_locus_tag="KI385_04740"
                     /pseudo=""
     CDS             875..>1273
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156968.1"
                     /locus_tag="KI385_RS04705"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04740"
                     /product="aminotransferase class III-fold pyridoxal
                     phosphate-dependent enzyme"
                     /pseudo=""
                     /transl_table=11
                     /translation="MADRGPFDRYVASASEVRSYSRPWPVALDRAEGSRLHSEEGHPYL
                     DFFAGAGALNYGHSNPFPKKVLLDHIARGGVPHALDMFTVAKRDFLETFEELVLIPRGL
                     DCKVVFPGPGGANAIEAALQPARKVTGRQ"
     misc_feature    956..958
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2061..2070
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    2198..2212
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.72"
                     /tool="antismash"
     gene            2372..2881
                     /locus_tag="KI385_RS04710"
                     /old_locus_tag="KI385_04750"
     CDS             2372..2881
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="KI385_RS04710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04750"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_238570961.1"
                     /transl_table=11
                     /translation="MAWPFPSGFRCRSSRPSHGAFESWAEAELALGRHTRVVEGIYELA
                     RRHPFHERLLSTQMPALYRSGRPAEALAQYEAMRQLLARELGLEPSPVLAGLYASLLSS
                     DGETEPLHRCPAHVWTQMRATAVHAPAPAEPARLQLSCGLMDFTGRRSATAELLDVLGD
                     AANGYG"
     gene            2967..5882
                     /locus_tag="KI385_RS04715"
                     /old_locus_tag="KI385_04755"
     CDS             2967..5882
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="KI385_RS04715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04755"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_238570962.1"
                     /transl_table=11
                     /translation="MADSSGYNGSGVAAAPFRVLGPLEVSGELGAVSVAPGRQEIVLGA
                     LVLELNRVVETTYLVDVIWAHRPPKTARAQVQICISRLRKALSDGKVDATIETRARGYI
                     LRAPEDATDVGNFRRLVTEAHALARDGLKMPAVETLRSAIGLWRGRCLAGVPSEVLAGT
                     AAQLDESRLEAVETCMRLLLELGRHEHLVGELMQLVAGHPLRERLRGHLMLALYRSGRQ
                     AEALDTYHQGRALLTEELGLDPGRELRDLAQAILTDAPGLALAEQPEPRAVVATQVSPS
                     AQELGADPDPVVTPRQLPADIGDFVADDTIVSAICDAVTEGQGKGPLSVALVLGRPGVG
                     KSTLATHVAHRLATEYFPDGQLYCDLRGLGGQPVDPAQALRRFLRALGIPGEAIPDSLD
                     ECAEMYRSLLADRRILVLLDDAVSESQVMPLLPGTGSSGVLVTSRSLLTALPGTRRFDL
                     EPLSPEQALQLLGRIIGEHRVEGEAEAARVLIRLVGGLPLALRIIGARLAARPHWSLTS
                     MWNRLENEHRRLDELAHGELSIRASLSLSYDGLAAADRRLLCLLSLAEGTVIPSWLGAA
                     LVDDRTLRPTDLLEPLIDMRLLDITAMDQGGEIRYGLSLIVRTFTQERLAAEIPEAERV
                     GAVRRMVGGWMALAERAHKEIYGGTYTLVSGQAERWHPPEDLVRRCLRDPLGWLESEQT
                     NLLSAVELAARSGLDELCWELATTLVTLFEARGYPDLWERTHRIALTAVQEAGNERGQA
                     AVLGSLGTLHLHRSEHEAAGPYLSAALGMFERIGEVRGQALCLRDLARIERHHGDDDRA
                     LALYESAERKFVQAEDVIGRAYVLGEMAHITMRRADFTRTRSYLDEALGICRSTGFDRG
                     QALVLRRLGQMLMYQQQYEAAERTLLEVLAMVRANGDPVGEGYVLHDLGRVNVDLRRVE
                     QAVEYYSQSARIRERILDHSGAAAVRADIVAILGRPVTSVS"
     misc_feature    4215..4217
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6356..6772
                     /locus_tag="KI385_RS04720"
                     /old_locus_tag="KI385_04760"
     CDS             6356..6772
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="KI385_RS04720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04760"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_238570963.1"
                     /transl_table=11
                     /translation="MRALLGLSRTVAQGAVHGLLGPNGAGKTTLVKIPSTILPPTTGYA
                     TVCGHDVVRNGRNVHPLIGVVMGCDRGLYTRLTGRQNLEFRGAVQKVPRRVLQSRTEHL
                     LDRLGLAAKADARVETYSRGMKQRLHLAPAAGRT"
     gene            6976..7734
                     /locus_tag="KI385_RS04725"
                     /old_locus_tag="KI385_04765"
     CDS             6976..7734
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013382.4"
                     /locus_tag="KI385_RS04725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04765"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_238577561.1"
                     /transl_table=11
                     /translation="MMNPDFYSRVADEFGEYTSGGLRTDVFPDGDPEAAFDELARGLGG
                     PDGRLVDVGCADGRSLLRIAPAFGSVLGIDMSASMLESAERKREVMGLGDVRFERRDAS
                     RTGLPDGEADVLTSRRGPLFPEEFRRVLKPGGHLIYMGIGETDVRELKEAFGRGQLYGR
                     WDGRPVMDEVVEELTGAGFTVVLEKAFRTEEFYHSPVELDKFLRQVPIFEDYDTAADRV
                     PFERYVASAGSDRGVRLDRHWFVVQARRAT"
     gene            7731..8990
                     /gene="ectB"
                     /locus_tag="KI385_RS04730"
                     /old_locus_tag="KI385_04770"
     CDS             7731..8990
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (21-357). E-value: 1.1e-65.
                     Score: 213.8. Matches aSDomain:
                     nrpspksdomains_KI385_RS04730_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009084079.1"
                     /locus_tag="KI385_RS04730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04770"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_238570964.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.6e-67, bitscore:
                     225.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIFDDLESEVRSYSRLWPVVFDRAEGSRLFSEDGRPYLDFFAGA
                     GALNYGHNNAFLKQALLDYIVRDGVSHALDMSTVAKRDFLETFQDLLLTPRGLQYKVAF
                     PGPGGANAVEAALKLARRVTGRQSVVSFTNSYHGMTLGALAVSGNAAKRAAAGVALTLT
                     TAMPYDGYPGIGETGPRYLDRLLSDGGSGLDRPAAVIVETVQGEGGLRAADADWLRDLA
                     GVCKRHEVLLIVDDVQMGCGRTGSFFSFEDAGITPDMVCLSKSIGGFGLPLALTLIRPE
                     LDVWKPGDHNGTFRGVSGSFVTGAQALRSYWSDGTLEKSTRERGERIAAALGAIAVEHP
                     EAGLEVRGRGFAAGLRFATPGAARAVCVAAFENGLLMETSGAAGDVAKLLPPLTISDDD
                     LDEGLDIIRTCVGPVLARSK"
     aSDomain        7794..8801
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KI385_RS04730_Aminotran_3.1"
                     /evalue="1.10E-65"
                     /label="KI385_RS04730_Aminotran_3.1"
                     /locus_tag="KI385_RS04730"
                     /protein_end="357"
                     /protein_start="21"
                     /score="213.8"
                     /tool="antismash"
                     /translation="FDRAEGSRLFSEDGRPYLDFFAGAGALNYGHNNAFLKQALLDYIV
                     RDGVSHALDMSTVAKRDFLETFQDLLLTPRGLQYKVAFPGPGGANAVEAALKLARRVTG
                     RQSVVSFTNSYHGMTLGALAVSGNAAKRAAAGVALTLTTAMPYDGYPGIGETGPRYLDR
                     LLSDGGSGLDRPAAVIVETVQGEGGLRAADADWLRDLAGVCKRHEVLLIVDDVQMGCGR
                     TGSFFSFEDAGITPDMVCLSKSIGGFGLPLALTLIRPELDVWKPGDHNGTFRGVSGSFV
                     TGAQALRSYWSDGTLEKSTRERGERIAAALGAIAVEHPEAGLEVRGRGFAAGLRF"
     gene            9003..10004
                     /locus_tag="KI385_RS04735"
                     /old_locus_tag="KI385_04775"
     CDS             9003..10004
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2OG-FeII_Oxy"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034427.1"
                     /locus_tag="KI385_RS04735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04775"
                     /product="2-oxoglutarate and iron-dependent oxygenase
                     domain-containing protein"
                     /protein_id="WP_238570965.1"
                     /sec_met_domain="2OG-FeII_Oxy (E-value: 5.1e-11, bitscore:
                     41.9, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGKIPEVDLEAWRKASDADRAPIAAELDAALRSTGLFLVSGHGV
                     PQAVIDDFRATAKRFFALRKEVKAQYAIEAPYDGGWLEMHPPGGVGVPVSEGEEAPSAP
                     DLHESFYVGPGHRTGDEQRDRFNYPANRWPVELPELRAAADAYTTHMLRVVQAVNEVLA
                     VTLGLPEDFFTSRAQLATWTQNASWYPSYSSIGEVARGQFRNGPHTDLGTVTLLSRQRG
                     VGGLQAWNEEDDWFSPPYSPDSLIVNLGDLMEQWTDGRWRALKHRVLPPSPAAPDEELL
                     SLVFFFETDPDTLIEPLAAPVGGGRGLSPAYARRTVLEKLGVSLDSVTGAEA"
     gene            10001..10681
                     /locus_tag="KI385_RS04740"
                     /old_locus_tag="KI385_04780"
     CDS             10001..10681
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070068.1"
                     /locus_tag="KI385_RS04740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04780"
                     /product="7-cyano-7-deazaguanine synthase"
                     /protein_id="WP_238570966.1"
                     /sec_met_domain="QueC (E-value: 1.1e-48, bitscore: 164.5,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 3.9e-06, bitscore:
                     25.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRIVTVVSGGIDSVTMAHHLAAEGHDLQVLAVDYGQRHRKELEF
                     AAAAAERLGAPYEEVDLRSLRSVMRGSSLTDPSVAVPRPDRPVGGNPNIVPNRNAVLLS
                     VAFALAVTVQADAVAFGVMAEDVGPSDTSPEFLRLFVEMERVATKGSLAPEVELLAPLI
                     ELPKTGVVALGEKLGVPWDKTWTCFRGEEIHCGACAACVERRGAFADLGITDPTVYREA
                     VIPQ"
     gene            10734..11447
                     /locus_tag="KI385_RS04745"
                     /old_locus_tag="KI385_04785"
     CDS             10734..11447
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980446.1"
                     /locus_tag="KI385_RS04745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04785"
                     /product="7-carboxy-7-deazaguanine synthase QueE"
                     /protein_id="WP_281066794.1"
                     /sec_met_domain="QueE (E-value: 8e-84, bitscore: 279.8,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6.1e-11, bitscore: 41.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 6.3e-13, bitscore: 48.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPELVVNEIFGPTVQGEGRSMGRRCAFLRLGGCNLSCTWCDTPY
                     TWDWTGAGDSGVKYDPRKELHRRPVREVAEELLAFGVELIVISGGEPLGQQNRLVPLVE
                     LLTARGLEIEIETNGTHAADPALVAAGVRFNVSPKLAHSGDAVNRRIVPDALKSLAVTE
                     GTTFKFVCRNAGDLDEVAGLVEEFGLDSVWIMPKGQTGAEVSRHMAELADAVITRGWNL
                     TTRLHTLLWGDTRGV"
     gene            11487..11849
                     /locus_tag="KI385_RS04750"
                     /old_locus_tag="KI385_04790"
     CDS             11487..11849
                     /EC_number="4.1.2.50"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070497 -
                     6-carboxy-5,6,7,8-tetrahydropterin synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: PTPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010356709.1"
                     /locus_tag="KI385_RS04750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04790"
                     /product="6-carboxytetrahydropterin synthase"
                     /protein_id="WP_238570967.1"
                     /sec_met_domain="PTPS (E-value: 4.5e-33, bitscore: 112.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRITKKFEFSASHRLSGLAEGHQCARLHGHNYVVELELSADLT
                     ELTPTGFVRDYGELAPFKSWLDQTLDHRHLNDLVDNNPTAENLAVWLYERWSKEFPELT
                     SVRISETPKTWAEYRP"
     misc_feature    complement(11896..11909)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     gene            11933..12526
                     /gene="folE"
                     /locus_tag="KI385_RS04755"
                     /old_locus_tag="KI385_04795"
     CDS             11933..12526
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0042559 - pteridine-containing compound
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: GTP_cyclohydroI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010356712.1"
                     /locus_tag="KI385_RS04755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04795"
                     /product="GTP cyclohydrolase I"
                     /protein_id="WP_238570968.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 2.6e-52,
                     bitscore: 175.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVTTWMQEDDVDSEKPREEDPLVGLARQLLKEIGEDPDRDGLRD
                     TPARFARWWREFINYEPGSVGTLFESIGPKQLVVVSDIQVWSLCEHHLLPFNCSVTIAY
                     RPTDRLLGLSKFARIAHRHAHKLQVQERLVSEIAEDIAVLSGAEDVAVIAKGEHLCMTM
                     RGIKAAAQMTSTAYRGAFGEDAGLRAEMFNLLRP"
     gene            12710..14095
                     /locus_tag="KI385_RS04760"
                     /old_locus_tag="KI385_04800"
     CDS             12710..14095
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="KI385_RS04760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04800"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_238570969.1"
                     /transl_table=11
                     /translation="MTLRREPTIAAGESIKQNIPLGFRQGCANGGGTGATPFGRRLRNL
                     RLQIGLSQKQLARSSTLSVRAIRDLENGRVRQPRADSLRLLADALGISAPQMNRLANEH
                     SLGFLAGAAEPAMSGPFIGREQELAALTTMLGAEHHRLVTITGIEGVGKTRLALEVAHA
                     LEAAEHSTVLWPPLDDGQLRSGRAPVGAPEQPTWLREVVHSGPDSRRRLVETIGESNSL
                     LVLDGARPEDELADITAHLLAACPRLRILVTTRNPVDMPLDTLFPLAPLPVPPSDTESA
                     DLEKVASVALLLAQAKRLQPAFRPDAHILADVARICRALDGLPAALESAAHWSLIYSLR
                     QLAHQLTIEPLTVARRPHGGHQQPDAYASVHHTIATLSSRQRDLLSTMSHKTSREIDGY
                     WSVPEVADKMGLTAAECADDIYHLLILGILRRVDHHDVAMFRVLNIVSIAGQNAIAGQN
                     AAA"
     gene            14123..15004
                     /locus_tag="KI385_RS04765"
                     /old_locus_tag="KI385_04805"
     CDS             14123..15004
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013706.4"
                     /locus_tag="KI385_RS04765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04805"
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="WP_238570970.1"
                     /transl_table=11
                     /translation="MRLCTLRTETGEDVGVSVTGGIATLSLINATAGTLYGPTMLDIIQ
                     KGEAVALASTVASLPDLGVPAAQGGPEFGPLYRCPPKLWGVGLNYVRHADDLGVRQPTD
                     APGSYMRPPSTVIGYGDDILLPSQSQRVTAEAELGVVIGTTCRDVSPEDAPSVIFGYTT
                     VLDMTAEDAIRVNPRHIPWAKAFDTFCSLGPWVVTPDEIPDLSAVRISTVVNGKTIASN
                     QVAAMMYDPYWQVGYFSGGMVLEAGTVIATGTPGAGVINDGDTVEARVDGVGDLRNTVR
                     LKPAKKHGDERV"
     gene            15059..15202
                     /locus_tag="KI385_RS04770"
                     /old_locus_tag="KI385_04810"
     CDS             15059..15202
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS04770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_04810"
                     /product="hypothetical protein"
                     /protein_id="WP_238570971.1"
                     /transl_table=11
                     /translation="MRHADIRRAATRLDEMDVDILFNWDHFFAHYGSPDSEHSECRTMP
                     GA"
     gene            <15215..15484
                     /locus_tag="KI385_RS04775"
                     /old_locus_tag="KI385_04815"
                     /pseudo=""
     CDS             <15215..15484
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012517.4"
                     /locus_tag="KI385_RS04775"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04815"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="SHVEFWPLVSCNSYRNPDLPADMARTVDHISGGRLVPGMGAGWSE
                     REFAEYGYEFGTAGSRLDDLGEALPRIEKRWDALTPGRPGRYGC"
     gene            15519..16007
                     /locus_tag="KI385_RS04780"
                     /old_locus_tag="KI385_04820"
     CDS             15519..16007
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012428.4"
                     /locus_tag="KI385_RS04780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04820"
                     /product="aminotransferase class III-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_238570973.1"
                     /sec_met_domain="Aminotran_3 (E-value: 5.1e-09, bitscore:
                     34.3, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLTAIRADVWHGFGGPEQMAEKHRVLDHWCASVGRDPGATQGII
                     EHARTIGDDVIAPGRASLAAKHPSVGDVRGLGVFCAIELVRDRDTREPLVPFNATGRAA
                     APINEVVAACTQHGLWPFSHFNRIHVVPPCTVTADEIREGLAVLDEALTLADRHCTGR"
     gene            complement(16066..16395)
                     /locus_tag="KI385_RS04785"
                     /old_locus_tag="KI385_04825"
     CDS             complement(16066..16395)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS04785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_04825"
                     /product="hypothetical protein"
                     /protein_id="WP_238570974.1"
                     /transl_table=11
                     /translation="MTYEATGDVTSLHQAARHSRDAVDTAGPEHPKYAIYASNLSSALR
                     FEYEQSGTPEALDEAIGHGYYAQAREVLSDINAVMYGRHDPPSRVGLAQAVDTASRKPY
                     WRFRP"
     gene            complement(16638..17936)
                     /locus_tag="KI385_RS04790"
                     /old_locus_tag="KI385_04830"
     CDS             complement(16638..17936)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024925.4"
                     /locus_tag="KI385_RS04790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04830"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_238570975.1"
                     /sec_met_domain="ATP-grasp (E-value: 7.4e-07, bitscore:
                     27.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPKDPVILLIDPANSRNGRNYKTAIRDLGFDALSLSTGLSTVAN
                     QQADLDHEMSLQASDVDDAVRQVRATEFDVRAVVPASGTSLHVADEIAARLGLPGNDPA
                     LGWARRNKAEMRVRAAQTGVRVPEFRLVHSLGEVAEAARDIGFPVIVKQTMGTGSFGVS
                     VISDAAALDEADNEWTVDRLGRPVTEWLVERYIRGREYAVNFCSADGEHRLIDIWEYRR
                     PDDRDYDFPLWDIIQIGGAHPDYVRVERFCRQVLDAFGIRQGPGHIEVKCSGDGDDVYL
                     IELAARFSGGPAVPMWTRHSDLRPFHDAVECYLGRRPNMIDGDHGFRAVLGSVVIRNDD
                     APGTLVAMHGLDELRALPGVADVLVEFRPGDHVPITNHNMCIPVSASVHGPDRATVLRT
                     IAIARETVRLEIAPDPADPADLTTVAPGAVAGG"
     gene            complement(18032..19066)
                     /locus_tag="KI385_RS04795"
                     /old_locus_tag="KI385_04835"
     CDS             complement(18032..19066)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF006049.0"
                     /locus_tag="KI385_RS04795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04835"
                     /product="hypothetical protein"
                     /protein_id="WP_238570976.1"
                     /sec_met_domain="HMGL-like (E-value: 1.6e-37, bitscore:
                     128.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSETSPMVAEDRRSSRVEILDCTLRDGSYAVDFNFTEGTIKSVLT
                     GLEESGVRFVELGHGLGLNAAERTPHPTRVSDALCFSIASETLTSASWGMFCIPGIAEL
                     DHLRQAVAAGMQFVRIGVDITAVAPAEAFIALAKDLGITTFANLMKTNVLGTDGVTDAV
                     RKCAEYGADTVYLVDSVGGYLPSDVAELFEKVGRSVTIPLGFHGHDNLSLANANSLAAA
                     MSGAQFVDTTLDGIGRGAGNTVTETFAATLHAQGNRNTYDFRALAELSESVIRPLERLH
                     DDRTYQLVGGITRTHSSFFPLISRCAKTANVDVFELMAAVADIDRVHPAEDMVLETANA
                     MAAR"
     gene            <19245..>19415
                     /locus_tag="KI385_RS04800"
                     /old_locus_tag="KI385_04840"
                     /pseudo=""
     CDS             19245..>19415
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018553410.1"
                     /locus_tag="KI385_RS04800"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="KI385_04840"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLLRLNNLNVHKAAGLRLLAEGRDRLTVYYLPPYAPDLNPVEGIR
                     SLLRRGRLSNGA"
     gene            complement(19430..20404)
                     /locus_tag="KI385_RS04805"
                     /old_locus_tag="KI385_04845"
     CDS             complement(19430..20404)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF020032.4"
                     /locus_tag="KI385_RS04805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04845"
                     /product="hypothetical protein"
                     /protein_id="WP_238570977.1"
                     /sec_met_domain="RimK (E-value: 1.4e-07, bitscore: 30.2,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADLVTMFWIRSERESKSPNPFDAEINSRYDDAARAAGVLLSRI
                     SVDDVVVGTTEVGASVRVRGALVAADTAFFHTKLVTWPVDRFDYWRHLTTYAALSAAGF
                     YTTFPVGYSLINNEKLITALRPFGSVVPRLPTVRLSTRGYGPDHLDWCTAAMRASDIGF
                     PVVVKPSSWGGGNSVFVASNAGELDTVLTWAAAAELTVVVQPWLGRDVVDYRVFYVDGE
                     PYRVLTRKPRGDALAGNVGQGGVAGWTAMPDALVAPARAVARDIELPYLCIDFLCADGQ
                     WWFSEIEIDGGTTQGDHHMTEVRFGSYRSRFDTFVRDLRSGVR"
     gene            complement(20394..20552)
                     /locus_tag="KI385_RS04810"
                     /old_locus_tag="KI385_04850"
     CDS             complement(20394..20552)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS04810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_04850"
                     /product="hypothetical protein"
                     /protein_id="WP_238570978.1"
                     /transl_table=11
                     /translation="MTAMRDSDSVLYWISVDGVVVGRNAGGPAVHVRGERLDPTASARG
                     GEVNRDR"
     gene            complement(20549..21475)
                     /locus_tag="KI385_RS04815"
                     /old_locus_tag="KI385_04855"
     CDS             complement(20549..21475)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS04815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_04855"
                     /product="hypothetical protein"
                     /protein_id="WP_238570979.1"
                     /transl_table=11
                     /translation="MPTASPPILFWLRSERDYTAVAAADHAHVAGLTAAAADLGLDLRT
                     ATVDDVVVTQVGEDAIVRVRGDRVDPRDTFFHTDSLGRPAQAPDTWRVLSTIGILEAAE
                     FMVTVPAVHSITWTDTIVSLLRFDLGEVRTLPSVRLCTREIEVHRDRLRVADWGLEFPV
                     AVRPAVRRPGDRVFIAESERRLTTLLQLVGASELTVLVQPWLGEHVVEHVVVCIDGEPT
                     GLEGALAERLSGPASSVATALGLAYVRVGFVQDADRFWLSHVDCTGFAPDLDADAVRVQ
                     LAAYREAFHRFRAAGDAVSASAHGGEA"
     gene            complement(21487..21711)
                     /locus_tag="KI385_RS44160"
     CDS             complement(21487..21711)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS44160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_238570980.1"
                     /transl_table=11
                     /translation="MTVVAQGEHLRVTMRGIETSAHLTSTAYLGVFGSDAQPDAELFAL
                     TLWLVLTTWRRHERLRTPAYEPLRQAPPN"
     misc_feature    complement(21686..21701)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.2"
                     /tool="antismash"
     gene            complement(21765..22418)
                     /locus_tag="KI385_RS04825"
                     /old_locus_tag="KI385_04865"
     CDS             complement(21765..22418)
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016812 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in cyclic amides
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016115.4"
                     /locus_tag="KI385_RS04825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_04865"
                     /product="cyclase family protein"
                     /protein_id="WP_238570981.1"
                     /transl_table=11
                     /translation="MPRTVDLSHPLEPGMPHARTVPAPKFTPTSTWAEHRMRVMRLDIP
                     THIGTHVDAPSHFVEDGATLDQLPPSALVGRAYCLEVLRDGPDPITAADLESAVDLEPG
                     DALLIRTGWDDRYGEPAYVDRHPYLAVDAAEWAVAKGLRFIGMDTISPDLPMSMRPPNF
                     PYDVHRTLLAAGTLIVENLVLREISNRWSTLFIGVLNVLGGDGAPARALAVLDD"
ORIGIN
        1 gaccggctac tggacgcccg agctgcgcaa cggcgccgac gaattctgag ccgtcggcgc
       61 cctgaagcca cagcaggttc gaccgtggcc ccggccgctt ctgccttgcc gctggccttg
      121 attgcccacg tggcacctct accggggcca ccgctgccat gtccacatca gtggggccct
      181 gcggcaatgc cgctgaatcg accgtatcca tagaggcagg gtcacgatga acccggaatt
      241 ccattcacag gtggccgaca agttcggcgg gtattccagc ggggcacaac gcacggaggt
      301 cttcccggac ggcgatccgg aggatgcgtt agacggcctg gcgatcgggc tggttcatac
      361 cggcgctcgc ctggtggacg tgggctgtgc cgacggccgc aacgtgctgc gcgtcgcgcc
      421 cgcgttcacc tcggttctcg gcatcgacct gtcgatgccg atgttggaat ccgccgggcg
      481 ccaccgggag accagcgggc tggaccacgt cgagttcgaa ctgcgtgacg cctccggcac
      541 cggtctgccc gatggcgacg tcgatgtgat cacctcgcgg cgcggaccgc tgttcccgga
      601 cgagttccgg aggatcctca aacccggcgg atcactgatc tacctcggca tcggggaaca
      661 gggcgtgcgc gagctgaagg aggccttcgg ccgcggccag ctctacggcc ggtgggacgg
      721 tcggccggtg gcactggaga cggccgagga gctgaccgga gcgggcttca ccgtcgtggc
      781 ggagaaggcc ttcttctacg aggagttctt ccactcaccg accgacctcg gcaccttcct
      841 ccagcaggtg ccgatcttcg aagactacga cccggtggcg gatcgcggtc cgttcgaccg
      901 ttacgtggca tcggcttccg aggtgcgaag ctacagccga ccgtggccgg tcgcgttaga
      961 ccgggcggaa ggcagccggc tccactccga agaaggccac ccctacctcg acttcttcgc
     1021 cggcgcgggt gccctcaact acgggcacag caaccctttt ccgaagaagg tcctgctgga
     1081 ccacatcgcc cggggcgggg tcccgcacgc gctggacatg ttcacggtgg cgaagcggga
     1141 cttcctcgag acgttcgaag agctcgtgct catcccgcgg ggactggact gcaaggtggt
     1201 gttccccgga cccgggggcg ccaacgcgat cgaggcggcg ctccagccgg cacgcaaggt
     1261 gaccgggcgg cagtggacgt ccgccggaat cacggcgggg agggacctgg cgttcgccat
     1321 ggtcgaggag gaccacgggc ccgaggtctc ccgggccgtc gcgcggatgc tggtgatgtc
     1381 cgtccaacgc ccgggcggcc aagcacagtt cagcacccag ctcgccgcgc agcggcccac
     1441 gcgtaagccg ctgcgggacg gataccacca tcgacgcgat cgtccgagtc tgcggcttcg
     1501 gcttcgccga gaccctgcac cgccgcttca aacgcaccct gggcgtcaca ccgggccagt
     1561 atcgccacca cttttcccgc gcacgatgaa ggagcgcctg ggctcggtcg tcgcggtgag
     1621 aagcccgagt gccaccggca cgtctccttg ggcgccttcg ggcactcggc ggacgccgag
     1681 caccccaggg cgggcacagc gggcacagcg ggcactgagc ggcccaccta tacactgtgc
     1741 gcatacacct catatagcgt gcgaggcatc gggttgtgca gcaccgtcag cccttcgctg
     1801 acccggacgc cgatctggtc gtgggactac acttcaacgg ccggacctgg cacgaacagc
     1861 gcatggagcg cacgttccgg gtcaacgacg cgctacacca cggcctcagt ctcatccagc
     1921 cgcacacacc gcacccttct ccccctcccc cgtcccggta cagcgctgat cggagcagtc
     1981 tcgatgaacg acaccacgcc ggcggagttc tccccgcccc ggaacgcaac ggcgggtggg
     2041 catccgtggg actgcaagtc gaaggcggcc gaacacgcgc cgggcaggcg ttcggtgaac
     2101 gttcccgagg cggggacggt cggccgcgga cccacggtgt ggttcggcat tctgggcccg
     2161 ctacaggccc gggtggcagc gggcgatgct gagacgttga agatcacctt caagcaacgt
     2221 gtccgccact cgcggttacc tgatccaggt ggccgcagca actcgacgcg ctgcagtttc
     2281 gggaactcgt gcacgccggg caagcggcgg agcgtaccgg tgatgtcgag gggggcggcg
     2341 cgggcgctcg gcgaggcggt ggccctatgg cgtggcctgg cccttcccga gcgggttccg
     2401 gtgccgctcg tcgcggccga gccacggtgc cttcgagagc tgggcggagg cagagctcgc
     2461 cctcggtcgt catacgcgag tggtcgaagg catttatgag ctggcgcggc ggcacccgtt
     2521 ccacgagcgc ctgctcagca ctcagatgcc ggcgctctac cgctcgggcc ggccggccga
     2581 ggccctagcc cagtacgagg ccatgcggca gctcctggcc cgtgagctcg ggctcgagcc
     2641 gagccccgtg ctggccgggc tttatgcctc actgctgtcg agcgacgggg agaccgagcc
     2701 gctgcaccgc tgcccggccc atgtatggac ccagatgcgc gcgaccgcgg tccacgcgcc
     2761 ggccccggcc gagccggccc ggctccagct gtcgtgcggg ctcatggact tcaccgggcg
     2821 acgatcggcg acagccgagc tcttggatgt gcttggcgac gcagccaacg gttacggctg
     2881 agtagccaac caggtcggca tgagttccgt ccaactttgc aagccggacc acatcgcctg
     2941 gctgatacca cagaagcagg gtatacatgg cagactcgtc aggttacaac ggcagcggcg
     3001 tagcggcagc tcctttccgg gtgctcgggc cgcttgaggt gagcggcgag ctgggggccg
     3061 tatccgtggc accggggcgt caagagatcg tcctcggggc tctggtgctc gaactgaacc
     3121 gggtggtgga gacgacctat ctggtggatg tcatctgggc tcaccgtcca ccgaagaccg
     3181 cacgcgccca ggtgcagatc tgcatctccc ggctccgcaa ggcactttcg gacggaaaag
     3241 ttgacgccac catcgagacc cgcgctcgtg gctacatcct gagggcgccg gaggatgcga
     3301 ccgacgtcgg caacttccgt cgcctggtaa cagaggcaca tgctctggcc cgtgatggtc
     3361 tgaagatgcc tgcggtggaa acgcttcgct cggcgatagg cctgtggcgg gggcggtgcc
     3421 tggccggtgt acccagcgag gtcctggccg gcacggcagc gcagttggac gagagccgcc
     3481 tggaagcggt ggagacctgc atgcggctgt tgctggagct gggccgtcac gagcacctgg
     3541 tcggcgagct gatgcagctt gtcgccggcc atccgctgcg tgagcggctg cgggggcacc
     3601 tcatgctggc gttgtatcgt tcgggccggc aggcggaggc gctggatacc taccaccagg
     3661 gccgcgcgtt gctcaccgag gaactgggcc tggacccggg cagggaactg cgcgacctgg
     3721 cgcaagcgat cctgaccgac gcccctggcc tggcactggc tgaacaaccc gaaccgcgtg
     3781 ccgtcgtggc aacgcaagtc tctccgtcgg cgcaagagct tggtgccgat cccgaccccg
     3841 tcgtcacacc tcggcaactg cccgccgaca tcggcgattt cgtagccgac gacacgatcg
     3901 tttcagcgat ctgcgacgcc gttaccgagg gccagggaaa agggccgctg agcgtggcct
     3961 tggtgcttgg caggcccggt gtcggcaaga gcacgttggc cacgcacgtg gcgcaccgac
     4021 tggcaaccga gtacttcccg gacggacagc tctactgcga tcttcgaggg ctgggcggac
     4081 aaccggtaga cccggctcag gcgttgaggc gattcctccg agcactgggc atacccggcg
     4141 aggccatccc cgattcgctt gacgagtgcg cggagatgta tcgcagtctg ctggccgatc
     4201 gccggatcct ggtgttactg gacgacgcgg tgagcgagtc gcaggtgatg ccgctgcttc
     4261 ccggaaccgg cagcagcggc gtgctggtca ccagccgcag cctgctgacg gcgttgccgg
     4321 gtacacgccg gttcgacctg gagccgctga gcccggagca ggccctccag ctgcttggac
     4381 ggatcattgg ggagcaccgg gtcgagggtg aggcggaggc agcgcgggtc ctcatacgct
     4441 tggtgggcgg gctgccgctc gcgctgcgta tcatcggcgc gcgtctggcc gcgcgcccgc
     4501 actggtcact gacctccatg tggaaccggc ttgagaacga gcaccgcagg ctggacgagc
     4561 tggcacacgg cgagctgtcg atccgggcaa gtctttcgct cagctacgac ggcctggcgg
     4621 cggccgaccg tcgcctgttg tgcctgctca gcctggccga aggaacggtg attccgagct
     4681 ggctgggtgc cgcccttgtc gacgaccgca cgctgcgccc cactgacctc ttggaaccgc
     4741 tcatcgacat gcggctgctc gacattacgg ccatggacca gggcggggag atccggtacg
     4801 gactgtcgct gatcgtgcgg acgttcacgc aggaacggct ggctgcggag attcccgaag
     4861 cagaacgtgt cggagcggtg cggcgaatgg tcggtggctg gatggcgctc gccgagcggg
     4921 cgcacaagga gatctacggc ggtacataca cgctcgtgtc cggccaggcc gaacgatggc
     4981 atccgccgga ggacctcgtc cggcggtgcc tccgcgaccc gctcgggtgg ctggagagcg
     5041 agcagaccaa ccttttgagc gcagtagagt tggcggcccg gtccgggctg gacgagttgt
     5101 gttgggagtt ggccaccact ctggtaacgc tcttcgaggc ccgtggctat cccgacctct
     5161 gggagcgcac gcatcggata gcgctgactg cggtacaaga ggccggcaac gaacggggcc
     5221 aggcggcggt tctcggctcc ttggggaccc tgcacctgca tcggagcgag catgaggcag
     5281 caggccctta cctcagcgcc gctctgggga tgttcgagcg gattggtgaa gtgcgtgggc
     5341 aggcactgtg cctgcgtgac ctggcgcgca tcgagcggca ccatggtgac gacgatcggg
     5401 cactggccct ttacgagagc gccgagcgta aattcgtgca ggcggaggac gtcatcggtc
     5461 gtgcgtacgt gcttggcgag atggcgcaca tcacgatgcg gcgagcagac ttcacgcgaa
     5521 cccgttcata tctcgacgaa gccctcggca tctgccggtc gaccggcttc gaccggggcc
     5581 aagccctcgt gctgcggcgg ttgggccaga tgctgatgta ccagcagcag tacgaggcgg
     5641 cggagcggac cctgcttgaa gttctcgcca tggtcagggc gaacggcgat ccggtcgggg
     5701 aagggtatgt gctgcacgac ctcggccggg tcaatgtcga tctgcgtcgc gtggaacaag
     5761 ccgtcgagta ctactcgcaa tcggccagga ttcgggagcg gatcctggac cacagcgggg
     5821 ccgctgccgt acgggctgac atcgttgcca tcctaggaag gcccgtgacg tcggtcagct
     5881 gacacgatct ggcggccggc cggtcacgtc cagggcgtgt tgtcggtggt tgggccgtcg
     5941 gcaagcgtca tggcggccgg caacttcttg acggacatct cagctctcct tcgatgtggc
     6001 cattcgtctc gcaacccgct tcgcgatccg tgcggcgttg ctggaaccag cgtgggccag
     6061 gtgcccatcg cggccgcatg cccgcgctat caccgtctta tcccggccct gtctgccgtg
     6121 gatgctccag gatgccgggc cgatagggcg acaccggaga ttggggtcct gccgacctcg
     6181 gcgccccttc aggggacggt cctcaaggag tagtccaatg accgtagtga cccgggaagc
     6241 ggtgacgcct gctctgttcg gcgccccgca acccgaaccg cagcacagca cggatccccc
     6301 cgcgatagca gcggtagacc ttgtcaggga gttcccccgg aagaggaagg acccggtgcg
     6361 tgcgctcctg ggcctctccc ggaccgtggc ccagggggca gtgcacggac tcctcggccc
     6421 gaacggggca ggcaagacga ccctcgtcaa gattccgagc accattctcc cgccgaccac
     6481 cggatacgcc acggtctgcg gccacgacgt cgtacgcaac ggccgtaacg tgcacccgct
     6541 gatcggtgtt gtgatgggct gcgaccgcgg cctgtacacg cggttgaccg gtcgccagaa
     6601 ccttgagttc cggggggccg tgcaaaaggt cccccgaagg gtattgcagt cgcgcaccga
     6661 gcacttgctg gaccgactcg gcctggcggc gaaggcggac gcgagggtcg agacgtactc
     6721 gcgcggcatg aagcagcggc tacacctggc ccctgcggcg gggcgtacct agcgctgagc
     6781 cttgcccgag aagtccgtac ggacggacat cgttgacgat gccggtccga gcaggaatcg
     6841 ctgaagcgcg atcacagcgc gtggctggta acgctttaac gcggtttttc cgtcggcggt
     6901 cggacgcaat acgacccaca tgccgaatgg attccgcgca gtggttctgc cggatcgatt
     6961 aaaccgaggt aggtgatgat gaacccggat ttctactcgc gggttgccga cgagttcggc
     7021 gaatatacca gcggggggct gcgtaccgac gtcttcccgg acggtgatcc ggaggccgcg
     7081 ttcgacgagc tggcgagggg cctgggcggt ccggatggcc ggctggtcga tgtcggctgc
     7141 gccgatgggc gcagcctgct gaggatcgcc ccggcgttcg gcagcgtgct cggcatcgac
     7201 atgtcggcgt cgatgctgga gtccgccgag cggaagcgtg aggtgatggg gctgggtgac
     7261 gtcaggttcg agcggcgtga tgcttcccgt accggccttc ctgacgggga ggctgacgtg
     7321 ctcacgtccc ggcgagggcc gttgttcccg gaagagttcc gcagggtgct caagcccggc
     7381 ggtcatctga tctacatggg catcggcgag acggacgtcc gcgagctgaa ggaggccttc
     7441 ggccggggcc agctctacgg ccgctgggac ggcagaccgg tgatggatga ggtggtggag
     7501 gagctcaccg gggccggttt cacggtggtg ctggagaagg ccttccggac cgaggagttt
     7561 taccactcgc cggtcgagct cgacaagttc ctgcgccagg tgccgatttt cgaggactac
     7621 gacacggcgg cggaccgggt tccgttcgag cgctatgtgg catcggccgg cagtgaccgt
     7681 ggtgtccggc ttgaccggca ctggttcgtg gtccaggcga ggagggcgac atgacgatct
     7741 tcgacgatct cgagtccgag gtccgcagct acagccggct gtggccggtc gtgttcgacc
     7801 gggcggaagg tagtcggctg ttctccgagg acggtcggcc ctacctggat ttcttcgccg
     7861 gtgcgggtgc gctcaactac ggtcacaaca acgccttcct caagcaggct ctgttggact
     7921 acatcgtccg ggacggggtc tcgcatgcgc tggacatgtc caccgtggcg aagcgggact
     7981 ttctcgagac cttccaggac cttctcctga cgccgcgagg gctgcagtac aaggtggcgt
     8041 tccccggtcc gggcggtgcg aatgcggtcg aggcggctct gaagctcgcc cggcgggtca
     8101 ccggacggca gtcggtggtg agcttcacca actcctacca cgggatgact ttgggggccc
     8161 ttgcggtcag cggcaatgcg gcgaagcgtg cggccgccgg cgtggctctg accttgacga
     8221 ccgcgatgcc ctacgacggc tatccgggca tcggggaaac cggcccgcgc tatctcgacc
     8281 ggctgttgtc ggacgggggc agcgggctgg accggcccgc tgccgtcatc gtggagaccg
     8341 ttcagggcga gggcgggttg agggccgccg acgcggattg gctgcgcgac ctcgcaggcg
     8401 tgtgcaaacg gcacgaggtg ctgctcatcg tggacgacgt ccagatgggc tgcggccgca
     8461 caggatcgtt cttcagcttc gaggacgccg ggatcactcc cgacatggtg tgtctgtcca
     8521 agtccatcgg agggttcggc cttcctctgg ctctcactct catccggccg gaactggacg
     8581 tctggaaacc gggcgatcac aacgggacgt tccgcggtgt cagcgggtct ttcgtgaccg
     8641 gagcacaggc gctgcgctcc tactggagtg acgggacgct ggagaagtcc acccgcgagc
     8701 gaggggagcg gatcgcggcg gccctgggtg ccattgccgt cgagcacccc gaggcgggcc
     8761 tggaggtccg gggccggggg ttcgcggccg ggctgcggtt cgccacgccc ggcgcggccc
     8821 gcgcggtgtg cgtcgcggcc ttcgagaacg gcctgctcat ggagacgtcc ggtgcggccg
     8881 gcgacgtggc gaagctgctg cccccgctga ccatcagcga cgacgacctg gacgaaggtc
     8941 tcgacatcat ccgtacctgc gtgggccccg tactcgcgcg gagcaagtga gaggtcacgg
     9001 ctgtgccagg caaaattccc gaagtcgacc tcgaggcgtg gcgtaaggca tccgacgccg
     9061 atcgcgcccc gatcgccgcg gagctggacg ccgcgctgcg cagcaccggt ctgttcctgg
     9121 tgtccgggca cggtgtgccg caagccgtga tcgacgactt ccgggccact gccaagcggt
     9181 tcttcgctct gcggaaggag gtcaaggctc agtacgccat cgaggccccg tacgacggcg
     9241 gatggctcga gatgcatccc cccggtgggg tcggggtacc ggtgagcgag ggcgaggagg
     9301 ccccgagcgc gccggacctt cacgagtcgt tctacgtggg gcctggtcac cgtaccggcg
     9361 acgagcagcg ggaccggttc aactatccgg cgaaccgctg gccggtcgag ctgccggagt
     9421 tgcgggcggc cgcggatgcg tacacgacgc atatgttgcg ggtggtgcag gcggtcaacg
     9481 aggtgcttgc cgtcacgctg gggctgccgg aggacttctt cacctcgcgg gcgcagctgg
     9541 cgacgtggac gcagaatgcc agttggtacc cgtcgtattc gagcatcgga gaggtcgctc
     9601 gcggtcagtt ccgcaacggg ccacataccg acctgggtac cgtcacgttg ctgagccgtc
     9661 agcgaggtgt gggtgggttg caggcgtgga acgaggagga cgactggttc tcgccgccgt
     9721 acagcccgga ctcgctcatc gtcaatctcg gtgacttgat ggagcagtgg accgatgggc
     9781 gttggcgggc gctgaagcac cgtgtgctgc cgcccagccc ggcggctccg gatgaggaac
     9841 tgctgtcgct ggtcttcttc ttcgagaccg accccgacac gctgatcgag ccgttggccg
     9901 ctccggtcgg tggtggccgg gggctgtcgc cggcgtatgc gcggcggacg gtcctcgaga
     9961 agctcggcgt ctcgctcgac tccgtcacgg gggctgaggc atgagcagaa tcgtaaccgt
    10021 ggtgtccggc gggatcgact cggtcaccat ggcgcatcac ctcgccgccg agggtcacga
    10081 ccttcaggtg ctggccgttg actacggtca gcgccaccgc aaggagctcg agttcgccgc
    10141 cgctgccgcg gaacggctcg gagcgccgta cgaggaggtc gatctgcgct cgctgcggag
    10201 cgtcatgcgc ggatcgtcgc tgacggatcc gtccgtggcc gtgccccgcc cggaccggcc
    10261 ggtcggcggg aacccgaaca tcgtgccgaa ccgtaacgcc gtgctgctgt cggtggcctt
    10321 cgcgctggcg gtcaccgtgc aggcggatgc cgtggctttc ggcgtcatgg ccgaggacgt
    10381 cggcccgtcc gacacctctc cggagttcct gcggctgttc gtcgagatgg agcgggtggc
    10441 gaccaagggt tcgcttgcgc ccgaggtcga actgctcgct ccgctgatcg aactgccgaa
    10501 gaccggagtc gtcgctctcg gcgagaagct cggagtgccc tgggacaaga cctggacgtg
    10561 ctttcgcggt gaagaaatcc actgtggtgc gtgtgcggcg tgtgtggaga gacgcggagc
    10621 gttcgcggat ctgggcatca cggacccgac ggtctatcgc gaagcagtga taccgcagtg
    10681 accggtgccg gccgcctcac cggtggcctc gacacggaag gaggcggtgc cgcgtggaac
    10741 cggaactcgt agtcaacgag atcttcggcc cgaccgtcca gggtgaaggc cggtccatgg
    10801 gccgcaggtg tgcgttcctg cggctcggtg gctgcaactt gtcgtgtacg tggtgcgata
    10861 cgccctacac gtgggactgg accggggcgg gcgactccgg ggtcaagtac gacccccgca
    10921 aggagttgca ccgccgaccc gtccgcgagg tggccgagga gctcctcgcg ttcggcgtcg
    10981 agctgatcgt catctccggc ggcgagccgc tcggccagca gaaccgactg gtcccgctgg
    11041 tcgagctgct cacggcgcga ggcctggaaa tcgagatcga gaccaacggc acgcacgccg
    11101 ccgacccggc cctggtggcc gccggagtcc gcttcaacgt ctcgccgaag ctggcccact
    11161 cgggcgatgc ggtcaatcgg cggatcgtgc cggacgcgct gaaaagcctc gcggtgacgg
    11221 aaggcaccac gttcaagttc gtctgccgca acgccggcga cctggacgaa gtagccggac
    11281 tggtcgagga gttcggcctc gactcggtct ggatcatgcc gaaggggcag acgggcgccg
    11341 aggtgagccg gcacatggcc gagctggccg acgcggtgat cacacgaggt tggaatctca
    11401 caacacgcct gcacaccttg ttgtggggcg acacgcgagg tgtctgaacg cgtggctgaa
    11461 tcaagcgaga aaggtgaatc ggagacatga cgctgcgcat cacgaagaag ttcgagttct
    11521 ctgccagcca tcggctctcc ggcctggccg agggacacca atgtgctcgg ctgcacggcc
    11581 acaactatgt cgtcgagctg gagctgagcg ccgatctgac ggaactgacg ccgacggggt
    11641 tcgttcgtga ctacggcgag ttggccccct tcaagtcgtg gctcgaccag acgctcgacc
    11701 accgtcacct caacgacctg gtggacaaca accccaccgc cgaaaacctg gcggtgtggc
    11761 tctacgagcg ttggtcgaag gagttcccgg aactgacatc cgtgcgaatc tccgaaaccc
    11821 ccaagacatg ggccgagtac cggccctgaa aagccggccg gctgacgaga gcagccgccc
    11881 gttcatcgga atctagcaac ggccgtgccg gtcggactgg agaggtgcct gaatgtctgt
    11941 gacgacgtgg atgcaggagg atgacgtcga ctcggagaag ccgcgagagg aagacccact
    12001 ggtcggactc gcccggcagc tcctgaagga gatcggggag gaccccgacc gcgacggact
    12061 gcgcgatacg ccggcgcggt tcgcccgctg gtggcgcgaa ttcatcaact acgagccggg
    12121 ctcggtcggt accctgttcg agtcgatcgg ccccaagcag ttggtggtcg tctcggacat
    12181 tcaggtctgg tccctctgcg agcaccacct gttgccgttc aactgctcgg tgacgatcgc
    12241 ctaccggccg accgaccggc tgctgggcct gtcgaagttc gcccggatcg cccatcggca
    12301 cgcgcacaag ctccaggttc aggagcggct ggtctccgag atcgccgagg acatcgccgt
    12361 gctcagcggg gcggaggacg tggccgtcat cgccaagggc gagcacctgt gcatgacgat
    12421 gcgcggcatc aaggcggccg cccagatgac ctcgacggcc taccgcgggg ccttcggtga
    12481 ggacgccggg ctccgggccg agatgttcaa cctgctgcgc ccctgaaacc gatccgcacc
    12541 ctgagaccca tccggggccg ctgccacggc cctgtacacc gatccggggc cgctgccacg
    12601 gccctgtacc gggtcgcggc agcggccccg aggagcatgt gccatggaaa caccatcggt
    12661 ggcaggaatc ggtcggatct ccactcggcc ttcggggcgg gagacgccga tgaccctgcg
    12721 ccgcgaaccg accatcgccg ccggtgagtc gatcaagcag aatattccgc tcggattccg
    12781 tcagggctgc gccaacggcg gcgggacggg ggctacgccc ttcggccgac gacttcgcaa
    12841 cctgcgacta cagatcggac tgtctcagaa gcagctggcg cgctccagca ctctcagcgt
    12901 tcgagcgata cgcgatctgg agaacgggag ggtacggcaa cccagggcag actccctgcg
    12961 ccttctcgcc gacgcccttg gtatcagcgc cccccagatg aaccggctgg cgaacgagca
    13021 ttcgctcggc ttcctggcgg gggcagccga gccggccatg agcggcccgt tcatcggccg
    13081 ggagcaggag ctggcggcgc tgacgacgat gctcggcgcc gagcaccacc gcctggtcac
    13141 gatcaccggg atcgagggcg tcggcaagac acggctcgca ctggaggtgg cgcacgcact
    13201 cgaggcagcc gagcactcga cggtcctctg gccgcccctc gacgacggcc agctccggag
    13261 cggaagggcg ccggtggggg ctccggagca acccacgtgg ttgcgcgagg tcgtgcactc
    13321 cgggcccgac agtcgtcggc gcctcgtcga gaccatcggg gagtcgaaca gcctcctcgt
    13381 cctcgacggt gcccggccgg aggacgagct ggcggacatc acagcccatc tcctggccgc
    13441 atgcccccgg ctgcggattc tcgtcacgac gagaaaccct gtcgatatgc ccctcgacac
    13501 cctcttcccc ctcgcaccgc ttccggtgcc cccatccgac accgagtcgg cggacctgga
    13561 gaaagtggcg tcggtggcgc tgttgctcgc tcaggcgaag cgacttcagc cggccttccg
    13621 tcccgacgct catattctcg cggacgtcgc ccggatctgc cgcgcactcg acggccttcc
    13681 cgctgctctc gaatccgccg cccactggag cttgatctac tccctgcggc agctcgccca
    13741 ccaactcacc atcgagccgc tcaccgttgc gcgacgaccc cacggcggcc atcagcagcc
    13801 ggacgcctac gcgtcggtcc accacaccat tgccacactg agcagccgcc aacgtgacct
    13861 gctatcgacc atgtcccaca aaacgtcccg cgaaatagac ggttactggt cggtgccgga
    13921 ggtggcggac aagatgggcc tgacggctgc ggaatgcgcc gacgacatct accacctcct
    13981 catcctcggc atccttcgcc gcgtcgacca ccacgacgta gcgatgttca gggttctcaa
    14041 catcgtcagc atcgccggac agaacgcaat cgccggacag aacgccgccg cgtgatctgg
    14101 gcaccacagg aaggatgaaa cagtgcgact ctgcactctt cgcaccgaga ccggtgagga
    14161 cgtcggcgtg tcggtgaccg gcggaatcgc cacactgagc ctcatcaacg cgaccgcagg
    14221 aaccctctac ggccccacca tgctggacat catccagaag ggcgaggccg tcgcgctcgc
    14281 gtccacggtc gcctccctgc ccgacctcgg cgtgccggcc gcgcagggcg ggccggaatt
    14341 cgggccgctg taccggtgtc cgccgaagct gtggggtgtg ggcctgaact acgtgcgcca
    14401 cgccgacgac ctgggggtac gacagccgac cgacgccccc ggctcctaca tgcggccgcc
    14461 ctccacggtg atcgggtacg gcgacgacat cctgctcccc agccagtcgc agcgcgtcac
    14521 cgccgaagcc gagctcggcg tggtcatcgg aaccacctgc cgcgacgtgt cacctgagga
    14581 cgccccgtcc gtcatcttcg gctataccac tgtcctggac atgaccgccg aggacgcgat
    14641 ccgggtcaac ccccgccaca ttccctgggc gaaggccttc gacaccttct gcagcctcgg
    14701 cccctgggtc gtcacccccg acgagatccc cgacctctcc gccgtgcgga tatccaccgt
    14761 cgtcaacggg aagacgatcg cgtccaacca ggtagctgcg atgatgtacg acccctattg
    14821 gcaggtcggc tacttctccg gcggcatggt cctcgaagcc ggaaccgtga tcgcgacggg
    14881 aacccccggc gccggcgtca tcaacgacgg ggacactgtg gaagcccgtg tcgacggcgt
    14941 cggcgacctc cgcaacaccg tcaggctcaa gcctgccaag aaacatggag atgagcgcgt
    15001 ctgaactgcc ctgcggccgc tacccggtcc gcatcggggt acagatccag ccgcaacggt
    15061 gcggcacgcc gacatccggc gggccgcgac ccggctggac gagatggatg tcgacatcct
    15121 gttcaactgg gatcacttct tcgcccacta cggcagcccg gacagcgagc actccgagtg
    15181 ccggacgatg ccgggcgcct gagcggaggc gacctcccac gtggagtttt ggccgctggt
    15241 cagctgcaac tcgtaccgga acccggacct gccggccgac atggcacgga cggtggacca
    15301 catcagtggc ggccggctgg tgccgggcat gggcgcgggc tggtcggagc gggaattcgc
    15361 cgagtacggc tacgagttcg gcacggccgg cagccggctc gacgacctgg gtgaggcgct
    15421 gccccggatc gagaagcgct gggacgccct gacccccggc cgacccggaa gatacggctg
    15481 ctgatcggcg gcaacgggtc aacggggtca acaagacatt gcggctgacc gcgatccgcg
    15541 ccgatgtctg gcacgggttc ggcgggcccg agcagatggc cgagaagcac cgggtgctcg
    15601 accactggtg cgcgtcggtc ggccgggacc cgggggcgac ccaaggcatc atcgagcacg
    15661 cccggacaat cggcgacgac gtcatcgccc cgggccgggc gtcgctggcc gccaagcacc
    15721 ccagcgtcgg cgacgtacgc gggcttggcg tcttctgcgc gatcgaactc gtccgtgacc
    15781 gcgacacccg cgaaccgctc gtgccgttca acgccaccgg gcgggccgcc gcgccgatca
    15841 acgaggtcgt cgccgcctgc acacagcacg ggctgtggcc gttcagccac ttcaaccgga
    15901 tccacgtcgt accgccctgc acggtgacgg ccgacgaaat ccgtgagggc ctggccgtcc
    15961 tggacgaagc gttgacgctg gccgaccggc actgcaccgg caggtgagat ccaaaggggc
    16021 gggccgcact ggtccgtccc ttcgcgatgt tggccgggcc ggcggtcagg gccggaatct
    16081 ccagtacggc ttccggctgg ccgtatcgac agcctgcgcc agacccaccc gtgaaggggg
    16141 atcgtggcgg ccgtacatca cggcgttgat gtcgctgagc acctcgcggg cctgcgcgta
    16201 gtagccgtgg ccgatggcct cgtcgagcgc ttccggtgtg ccggattgct cgtactcgaa
    16261 ccgcagcgcc gacgacaggt tggaagcgta gatggcgtac ttggggtgct cgggtcctgc
    16321 ggtgtcgacg gcgtcgcggc tgtgccgtgc cgcctggtgc aggctggtca cgtcgccggt
    16381 ggcttcgtag gtcatgcgca gggcaggtcc gaggtgggtg agccggccgg gcagggccgg
    16441 gtggtcgcgc gccgtacccg agacagcagc ctgaggggga cagccgactc cgaggcagcg
    16501 atcacggccc agccgcggaa ccgacggcgc agcccaccgt cgttgccgag ttggcccagc
    16561 cttgtgccgt gtgctcggcg ccgccggggt tacggcaccg agcacgctgg tccacaaacc
    16621 gtcgagcccg gcccccctca gcctccggcg acggcgcccg gtgccaccgt agtcaggtcg
    16681 gcagggtcgg cagggtcggg tgcgatctcc agcctgaccg tctcccgcgc gatggctatg
    16741 gtgcggagca cggtcgctcg gtccgggccg tgcaccgagg cgctgaccgg aatgcacatg
    16801 ttgtggttgg taatcggcac gtggtccccg ggccggaact ccacgagcac atcagcgacg
    16861 ccgggcaggg cgcggagctc gtccagccca tgcatggcca ccagcgtgcc gggtgcgtcg
    16921 tcgttgcgaa tgacaacgga gccgagcaca gccctgaacc cgtgatcccc gtcgatcatg
    16981 ttcggacggc ggccgaggta gcattccacg gcgtcgtgga acggacgcag gtcagagtgc
    17041 ctcgtccaca tcgggaccgc aggcccgccc gagaaccggg ccgcgagctc gatcaggtag
    17101 acatcgtctc cgtcgccact gcatttgacc tcgatgtggc ctggtccctg acggatgccg
    17161 aacgcgtcga gcacctgcct gcaaaaccgc tccacccgga cgtagtcggg atgggcgccg
    17221 ccgatctgga tgatgtccca caggggaaag tcgtagtcgc ggtcgtcggg ccgtcggtac
    17281 tcccagatgt cgatcagtcg gtgctcaccg tcagcgctac agaaattcac cgcgtactcg
    17341 cgcccgcgta tgtagcgctc caccaaccat tcggtgaccg gccgaccgag ccggtccacc
    17401 gtccactcgt tgtccgcctc gtccagagcc gccgcgtcac tgattaccga aacgccgaag
    17461 gagcccgttc ccatcgtttg cttcacgatg acgggaaagc cgatatcccg tgcggcctcc
    17521 gccacctcac cgagggagtg gaccagccgg aactccggaa cgcggacccc cgtttgcgcg
    17581 gccctgaccc gcatttccgc cttgtttcgc cgcgcccagc ccagagcggg gtcgtttccg
    17641 ggcaggccga gccgcgccgc gatctcgtca gccacgtgga ggctcgtccc actggcgggg
    17701 acgacggctc gcacgtcgaa ctcagtcgca cgaacctgcc ggacggcgtc gtccacgtcg
    17761 ctggcttgga gcgacatctc gtggtcgagg tcggcctgct ggttcgcgac tgtggagaga
    17821 cccgtggaca gcgagagcgc gtcgaaacca aggtcgcgta tggcggtctt gtagttgcgt
    17881 ccgttcctgc tgttggcggg gtcgatcaac aggatcactg ggtctttcgg ttccacagaa
    17941 actcttctcg ggccaggcgt gcgaatggtc aggggcgggt gagggcgagc agctctgcgt
    18001 acagcgtcac caacgtccgt agcgacgacg actagcgcgc agccatggcg ttggcggtct
    18061 ccagcaccat gtcctccgca gggtggaccc ggtcgatgtc ggcgactgcg gccatcagct
    18121 cgaagacgtc gacgttcgcg gtcttcgcgc acctgctgat cagcgggaag aagctggagt
    18181 gcgttcgggt gataccgccg acgagctggt acgtgcggtc gtcgtgcagt cgctccaacg
    18241 ggcggatgac ggactcgctc agctccgcga gagcccggaa gtcgtacgtg ttgcgattgc
    18301 cctgggcgtg gagggtcgct gcgaacgtct cagtgacggt gttgccggcg ccgcggccga
    18361 tgccgtcgag cgtcgtgtcg acgaactgtg ctccgctcat cgctgccgcg agcgagttgg
    18421 cgttggccag gctcaggttg tcgtgcccgt ggaagccgag cggaatcgtt accgaccgac
    18481 cgaccttctc gaacagctcg gcgacatccg acggcaggta accacccacc gagtcgacga
    18541 ggtagacggt gtcggcgccg tactccgcgc acttccggac cgcatccgtg acaccgtcgg
    18601 tgccgagcac gttcgtcttc atgaggttgg cgaacgtcgt gatgccgagg tccttggcga
    18661 gggcgatgaa agcctcggcc ggtgcgacgg cagtgatatc cactccgatc cggacgaact
    18721 gcatgccggc ggccacggcc tgtctgaggt gatccagctc ggcgattcct gggatgcaga
    18781 acatccccca actcgcgctc gtcagcgtct cggacgcgat gctgaagcac aatgcgtcgg
    18841 aaacacgggt gggatgaggt gtgcgctcgg cggcgttgag gcccaacccg tgacccagct
    18901 cgacgaaccg gacaccggat tcttcaagac cggtcaggac gctcttgatc gtaccttcgg
    18961 tgaaattgaa gtccacggcg taactaccgt cgcggagcgt gcagtccagg atttcgactc
    19021 tagatgatcg cctgtcctcg gcgaccatcg gcgatgtctc tgacattgaa cacctcaagc
    19081 agagaagtat gggaaggcgg tgtgtcgaca ctagtcgaga aatgcacatc cgccagcggc
    19141 agaagcccgg caggaaagcg cacattgacg ggcgcaaatg cctcccgaga cagcgaggaa
    19201 cggcaaagaa agagggcaga gttgcaccga gtcgtcgaga ccatctccta ctgagattga
    19261 acaacctcaa cgtccacaaa gccgccggcc tacggctgtt ggccgaaggc cgggaccggc
    19321 tgaccgtcta ctacctgccg ccctacgcgc ccgacctcaa ccccgtcgaa gggatccggt
    19381 ccctcctacg acgcggccgg ctctccaacg gcgcccgggg cagcgccagt cagcgcacac
    19441 ccgatcggag atcacggaca aacgtgtcga agcgggagcg gtaggagccg aagcgcacct
    19501 cggtcatgtg gtggtcaccc tgggtggtgc cgccgtcgat ctcgatctcg gagaaccacc
    19561 attgcccgtc ggcacagagg aagtcgatgc agaggtacgg cagctcgatg tcgcgggcca
    19621 ccgcccgggc cggggcgacc agcgcatcgg gcatggcagt ccaccccgct acgccgcctt
    19681 ggcccacatt gcccgcgagt gcgtcgccgc gcggtttgcg ggtcagcacg cggtacggct
    19741 caccgtcgac gtaaaacacg cggtagtcga ccacgtcccg tcccaaccac ggctgtacca
    19801 caaccgtcag ctcagccgcg gccgcccagg tgagcacggt atccagttcc ccggcgttgg
    19861 aggcgacgaa gacgctgttc ccgcctcccc aactggaggg tttgacgacc accgggaaac
    19921 cgatgtcgct cgcacgcatc gcggcggtac accagtcgag atggtccggg ccatagccgc
    19981 gggtactcag gcgcaccgtc ggcagccgcg gcaccacact gccgaagggc cgcagcgccg
    20041 tgatcagctt ttcgttgttg atcaggctgt atccgacggg gaatgtggtg tagaacccgg
    20101 ccgccgacag ggcggcgtag gtcgtcaggt gccgccagta gtcgaaccgg tcgaccggcc
    20161 acgtgaccag cttcgtgtgg aagaaggccg tgtccgctgc aacgagcgcg ccgcgcacgc
    20221 ggactgaggc acccacctcc gtggtgccca cgacgacgtc gtcgacgctg atccggctca
    20281 gcagcacgcc ggccgcgcgc gcggcgtcgt cgtaccgtga gttgatctcg gcgtcaaagg
    20341 gattcggaga cttgctctcg cgctccgagc ggatccagaa catcgtgacg aggtcagcgg
    20401 tcacggttca cctccccacc ccgggcagac gcggtgggat ccaggcgttc accgcggacg
    20461 tgcaccgcgg ggccgcccgc gttccggccg acgaccacgc cgtcgacgct gatccagtac
    20521 aggaccgaat cgctgtcgcg cattgctgtc acgcttctcc tccgtgtgcc gaggccgaaa
    20581 ccgcgtcgcc cgcggcacgg aaccgatgga atgcttcgcg gtaggcggca agctggactc
    20641 ggacggcatc ggcgtcgagg tcaggcgcaa agcccgtgca gtccacgtgt gacagccaga
    20701 accgatcggc atcttggacg aacccgaccc ggacgtaggc gagtccgagc gcggtcgcga
    20761 ccgaactcgc ggggccggac agccgctcgg cgagcgcccc ttccagaccg gtcggctctc
    20821 catcgataca caccacgacg tgctcgacga cgtgctcgcc gagccatggc tgcacgagga
    20881 cggtcagttc ggatgcaccc accaactgga ggagggtggt cagcctgcgt tcgctctcag
    20941 cgatgaagac ccggtcgccg ggccggcgga ccgccgggcg caccgctacc gggaactcca
    21001 gcccccagtc ggcgacgcgc agccggtcgc gatggacctc gatttcgcgg gtgcacagcc
    21061 gcaccgacgg cagagtgcgc acctcgccca ggtcgaaccg aaggagcgac acgatcgtgt
    21121 cggtccaggt gatcgagtga acggcaggca cggtgaccat gaactcggcg gcttcgagaa
    21181 tcccgatggt gctcagcact cgccaggtgt cgggtgcctg tgcgggcctg ccgagcgagt
    21241 cggtgtggaa gaaggtgtcg cgcgggtcca cgcggtcgcc ccgcacacgc acgatggcgt
    21301 cctctcccac ctgggtcacg accacgtcgt cgaccgtggc cgtgcgcaga tcgagaccga
    21361 ggtccgccgc tgctgcggtc aggcctgcta cgtgcgcatg gtcggccgcc gcgactgcgg
    21421 tgtagtcgcg ttccgagcgc agccagaaga gtatgggggg agaggcggtg ggcatggatc
    21481 tcgctcctag ttcgggggcg cctggcgaag gggctcgtaa gccggcgtcc gaagtcgttc
    21541 gtgccggcgc caggtggtca ggaccagcca aagggtgagc gcgaagagtt ctgcgtcggg
    21601 ttgggcgtcg ctgccgaaga cgccgaggta ggcggtcgag gtcaggtggg cactggtctc
    21661 gattccgcgc atcgtgacgc ggaggtgttc gccctgggcg acgacggtca cgtccgggct
    21721 gccggtgatg gcgcggacgt caccggcagc ggcgttgaaa gggctcagtc gtccagcacg
    21781 gccagtgccc gcgcgggcgc gccgtcgccg ccgaggacgt tgagcacgcc gatgaacagc
    21841 gtgctccacc ggttcgagat ctcccgcagc acgaggttct ccacgatcag tgtgccggcg
    21901 gccagcagcg tgcggtgcac gtcgtagggg aagttcggcg gacgcatgct catcggcaga
    21961 tcagggctga tcgtgtccat gccgatgaac cgaagtcctt tggccacagc ccattcggcc
    22021 gcgtcgaccg cgaggtacgg gtgcctgtcc acataggccg gttcgccgta gcggtcgtcc
    22081 cagccggtgc ggatcagcag tgcgtcaccg ggttcgaggt caacggcgga ctccaggtcg
    22141 gccgccgtga tcggatcggg accatcccgc agcacctcga ggcagtacgc ccgaccgaca
    22201 agcgccgacg gcggcaactg gtcgagcgtg gcgccgtcct cgacgaaatg tgacggggcg
    22261 tccacgtggg taccgatatg agtcggtatg tccagtcgca tgacccgcat ccggtgttcc
    22321 gcccatgtgc tggtgggcgt gaacttggga gccgggaccg tgcgcgcgtg cggcatgccc
    22381 ggttccagcg ggtgtgagag atcaaccgta cgtggcatgc ggtgctttct ccttaaactt
    22441 ggcgatctta ctacgcgatt cggactcgtg cagcgctaag cttgcctcga tttaattggc
    22501 tcgcccatcg tcctgtaccc cataaa
//
