LOCUS       NZ_CP084681            22046 bp    DNA     linear   CON 30-APR-2024
DEFINITION  Streptomyces inhibens strain NRRL30439 chromosome, complete genome.
ACCESSION   NZ_CP084681
VERSION     NZ_CP084681.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces inhibens
  ORGANISM  Streptomyces inhibens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Gillane,R., Talbo,G.H., Plan,M., Palfreyman,R.,
            Haber-Stuk,A.K., Power,J., Nielsen,L.K. and Marcellin,E.
  TITLE     Multi-omic characterisation of Streptomyces hygroscopicus NRRL
            30439: detailed assessment of its secondary metabolic potential
  JOURNAL   Mol Omics 18 (3), 226-236 (2022)
   PUBMED   34989730
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Palfreyman,R. and Marcellin,E.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2021) EMS, Australian Institute for Bioengineering
            and Nanotechnology, Cnr College Rd & Cooper Rd, Brisbane, Queensland
            4103, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. APRIL-2018
            Assembly Name                     :: AIBN_shyg
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 239.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022221585.1-RS_2024_04_30
            Annotation Date                   :: 04/30/2024 04:58:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,775
            CDSs (total)                      :: 8,682
            Genes (coding)                    :: 8,305
            CDSs (with protein)               :: 8,305
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 377
            CDSs (without protein)            :: 377
            Pseudo Genes (ambiguous residues) :: 0 of 377
            Pseudo Genes (frameshifted)       :: 158 of 377
            Pseudo Genes (incomplete)         :: 310 of 377
            Pseudo Genes (internal stop)      :: 38 of 377
            Pseudo Genes (multiple problems)  :: 116 of 377
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:32:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 512676
            Orig. end                         :: 534722
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084681.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Australian Institute for
            Bioengineering and Nanotechnology, Building 75,Cnr College Rd &
            Cooper Rd, Brisbane City QLD 4072.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22046
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="5"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22046
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22046
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12046](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12046
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            34..>540
                     /locus_tag="KI385_RS02450"
                     /old_locus_tag="KI385_02455"
                     /pseudo=""
     CDS             34..>540
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_123108376.1"
                     /locus_tag="KI385_RS02450"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02455"
                     /product="DUF4158 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPVEILTDEQAEAYGTFTAVPTRPELERFFFLDDGDRDLIARRRT
                     DAHRLGMAVQICTVRYIGRFLGEDPLAVPWEVVEHLAGQLGIEDSSCVKRYPERRSTVY
                     EHADEIQERFKYRDFTDRKWGREFRSFLYGRAWTHAEGPVALFNHAVTWLRKNRGLLPG
                     VSALAR"
     gene            complement(1102..1395)
                     /locus_tag="KI385_RS02455"
                     /old_locus_tag="KI385_02460"
     CDS             complement(1102..1395)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987675.1"
                     /locus_tag="KI385_RS02455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02460"
                     /product="DUF1330 domain-containing protein"
                     /protein_id="WP_012891307.1"
                     /transl_table=11
                     /translation="MAKGYWVSVYPAISDPEGLTDYNELAGLAVRAGGGRVLSNFGRVV
                     AHEAGITERVVLIEFDGFEQAVAAYESEAYQKALVALPDGFERDFRIVEGID"
     gene            1653..2687
                     /locus_tag="KI385_RS02460"
                     /old_locus_tag="KI385_02465"
     CDS             1653..2687
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1015: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059152.1"
                     /locus_tag="KI385_RS02460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02465"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_238577542.1"
                     /transl_table=11
                     /translation="MRPEPRPAAHKVVVLVVDGIYPFELGIPQHVLGSAGGRYEVVTAG
                     VDGKPVRTVSDLTVTPGHGPEVLAEADTVIIPGYAITQAPAAATDSKALDALSRVRPGT
                     RLVSICSGAFLLAGTGLLDGRRATTHWALSDRFRELFPRVELDAGVLFVDHGDVLTSAG
                     AASGFDVCLHLLRQDHGTEVANQVARFCVMPPYRDGGQAQYIERPLPPTGATGTGPTRD
                     WALQRLELPLSLDELAAHAAMSTRTFARRFKEETGLSPGRWLTSQRLRRARHLLESSDL
                     PVERVAHEVGFATATSLRRHLAAEAGVAPSAYRRTFRAPDPAAGDAGSIPHLVVASVSV
                     ADHR"
     gene            complement(2661..3530)
                     /locus_tag="KI385_RS02465"
                     /old_locus_tag="KI385_02470"
     CDS             complement(2661..3530)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020548578.1"
                     /locus_tag="KI385_RS02465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02470"
                     /product="PhzF family phenazine biosynthesis isomerase"
                     /protein_id="WP_238570587.1"
                     /transl_table=11
                     /translation="MSWPVVTVVDACVRRDGRGGSPTAVTDDDPAATDADRRAVAAAAS
                     TSHAAFLGPGRTPDGGWPVRFFTATAELSGCGHGTVAAQAVRLTRTALGELNDRQHTGG
                     RTFDTVAIRRPAGIEVWFDQGLVALRHPAPDERAAIVAALGLTADDPHPTDAPRIAAPG
                     APRMLVPVHDRSALLRVRPHLGRLTAACQRYGLLGCFVYVPPVGDRPGAARMFAPAIGV
                     DEDVANANSTGCLAAHLLDTTGAQTVAIEVEQGDTLGRPASVLASARRGPAGITTRVGG
                     LAVVRDGH"
     misc_feature    complement(2685..2687)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(<4139..>4237)
                     /locus_tag="KI385_RS02470"
                     /old_locus_tag="KI385_02475"
                     /pseudo=""
     CDS             complement(<4139..4237)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014137846.1"
                     /locus_tag="KI385_RS02470"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="KI385_02475"
                     /product="undecaprenyl diphosphate synthase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEHHLATAGLPNLDLLIRTSGEPRLSGFLLWQA"
     gene            complement(4270..5409)
                     /locus_tag="KI385_RS02475"
                     /old_locus_tag="KI385_02480"
     CDS             complement(4270..5409)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02480"
                     /product="hypothetical protein"
                     /protein_id="WP_238570588.1"
                     /transl_table=11
                     /translation="MPSQLAPLAEALTPNPYTVLDWLSTSRSAALLAELAELAEHRSDL
                     THDVLDALPQTRVTRHVRAVLVTTGVLPPRQERLAQMNLWLDKALGHAPPPHRQVVRPF
                     AEWGLLRHARRSAAHDRYSGSAARRDRSQVQAALDFLSWLDDEGLDLSSLAQEHLDRWL
                     ATRPARYDTLHAFIRWATARHLTGPLTLPSRPRSSASHFLTETAYEQQLRRCLNDETLQ
                     RELRIAGALICLYALPVSRIIELTTSRFHREGQGTAYLTFERHPVLLPPKLARLIEDQI
                     IHRSTTNSLNHELGASDRYLLPGTVPGSPIDGGTLAKLLGEKGLPVRAARNTAMIEAVT
                     SLPPIVVADLLGLHPATVGRWSDQANDSWASYLAARPKA"
     gene            5416..5739
                     /locus_tag="KI385_RS02480"
                     /old_locus_tag="KI385_02485"
     CDS             5416..5739
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02485"
                     /product="hypothetical protein"
                     /protein_id="WP_238570589.1"
                     /transl_table=11
                     /translation="MPSAETVFDALREGAARAQATRQEISGGIAAGTSCVRVVAAAAGS
                     AQALAFWCPADHDADLPGSMAEALTEGTSLPSDQPGPGHLVLTDDEIATYRARIAHLTA
                     VSR"
     gene            complement(5819..6853)
                     /locus_tag="KI385_RS02485"
                     /old_locus_tag="KI385_02490"
     CDS             complement(5819..6853)
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007824995.1"
                     /locus_tag="KI385_RS02485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02490"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_238570590.1"
                     /transl_table=11
                     /translation="MIDRIEALLAEGVRDKVYPGAVWAVGDSAGVQASGTTGVLDPDEP
                     ETPMRPDTVFDAASLTKILAVWSSIGALWEDSVLDLDQPLGSFWPEVENRPLGQVTARQ
                     LLTHTAGVPLRAQLKSLYGTREDDIRRGVLHEGLHRPPGEAVEYTDRAALILGFLAEYL
                     AGQPLDQVADARTWRPLGMDSTRFGPLPAPIAARCAPTELDPETDTHLKGTAHDFSARL
                     LGGVCGIAGAFTVLDDLTGFLRYMLDASTAPTEAGFGPEWTSYSLTVQTNGLEPARGLF
                     WHPAPGTSDEQDVWVHYGFTGTGMWISPATDRWAVLLTNKLYYTRDRQPLTDVRNTFRE
                     LAFA"
     misc_feature    6814..6828
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            complement(6932..>7192)
                     /locus_tag="KI385_RS02490"
                     /old_locus_tag="KI385_02495"
                     /pseudo=""
     CDS             complement(6932..>7192)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009300349.1"
                     /locus_tag="KI385_RS02490"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02495"
                     /product="glycosyltransferase"
                     /pseudo=""
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.1e-05,
                     bitscore: 24.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LVALEAQACGLPVLYQPVPGLRDALGATAVATDFTQPAAVARHLE
                     RLRTTTALLPALREASYANAARYPLSATARALHTLGRRLTH"
     misc_feature    complement(7311..7325)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
     gene            7383..7721
                     /locus_tag="KI385_RS02495"
                     /old_locus_tag="KI385_02500"
     CDS             7383..7721
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02500"
                     /product="hypothetical protein"
                     /protein_id="WP_238570591.1"
                     /transl_table=11
                     /translation="MASIWVLTQPADTSKQEAILADVITGVRGSKTSVYAIRSDTRDLV
                     PLVEWSTSFDKRDPLPAGFYISFLQTLDEAQRKNADLNRLIMAKWVIDQQEWQWLVQDI
                     EDLAPREF"
     gene            complement(7822..8826)
                     /locus_tag="KI385_RS02500"
                     /old_locus_tag="KI385_02505"
     CDS             complement(7822..8826)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135511.1"
                     /locus_tag="KI385_RS02500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02505"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_238577543.1"
                     /transl_table=11
                     /translation="MDRRQFLTASAAVGLAALDLPDAEAVTRHSNRPGPVAVGRGEVAA
                     VRTMTTTLGDAASELGGGHARHLAVRYLTVDVKRWLDGRYTDTVGRELFAATSELVHLI
                     GWMARDEGNQGLSQKYNLHSFRLAAEAGENELAATALRGLADQAIDLGHIPTAVRLAEA
                     CEQRGRKLNNPKALAYYRNTYARAAAADGDRTTAAKLLTFAQTAIENAPAMPGQSWASH
                     YSHGRWAHESGMIHATMGDLAAAEEHLHLALDIHGLDRKRTRAIVLADLGHVQLKRGNT
                     AQALATWNDFLDCADGVQSVRINDGLSNIAARLPNIPHSAATQELSQRLASRS"
     gene            9242..9367
                     /locus_tag="KI385_RS02505"
                     /old_locus_tag="KI385_02510"
     CDS             9242..9367
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="KI385_RS02505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02510"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_238570592.1"
                     /transl_table=11
                     /translation="MEHTITPVYQAPVVLDAGDVVAVTLGTNNFDTADDTQYKNA"
     misc_feature    9254..9268
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            9522..9995
                     /locus_tag="KI385_RS02510"
                     /old_locus_tag="KI385_02515"
     CDS             9522..9995
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02515"
                     /product="hypothetical protein"
                     /protein_id="WP_238570593.1"
                     /transl_table=11
                     /translation="MRWSAGWYGGTGHDRLPAGGRAMPGLDRTWTVGWPGARVRAVGEG
                     HVALAVVGECGADNAQLERALPVVRAKGWRTLTRWPGSYLTIARSGEVLAVIGDLAGQH
                     PVYWRLTALEPGGRPPPPLWRRWTGLLPIRPRWPLTSPWPSRTSWGSGACSAR"
     gene            10001..11347
                     /locus_tag="KI385_RS02515"
                     /old_locus_tag="KI385_02520"
     CDS             10001..11347
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="KI385_RS02515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02520"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_238570594.1"
                     /sec_met_domain="Asn_synthase (E-value: 4e-26, bitscore:
                     91.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTGHLLLIGPEGAGALRYEPAEYGPVDLRDAAPTVRAALSEAVG
                     FRCDGRPVSADLAGLDSTTLACLAAQRGAVAAVTFADARLRDDDLAYAVRTAAAVPNLA
                     HHTVPGSPETVYYAGLEDLSALPVTDAPNAYVVTASIKRAVLDPVAGRHTAGVHLTGAA
                     GDAVLSAPSSYLADLLRERQHHRAWQHAQAHARLRHTSALSLLRRARPAARTDLAGALR
                     TTAAELRRPPRPWVPQAERPVSWAPLLATADWMSLDLRDRLASALDVAAELADGPARLA
                     AWASRQDLARVGADTTGWREIALTGYGIEVAAPFLDNEVIRACLAVPADQRGTPGRYKP
                     LLGEAFAPAGVLPPFALARSTKGGFNALAYAGLREHASVLRDLLGPSSRLAAAGLITEA
                     PVDTMLQRAAAGQPTAQGALHLAVAAEVWLRQLETAPAWWEVDSRVATA"
     misc_feature    10118..10120
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11331..11627
                     /locus_tag="KI385_RS02520"
                     /old_locus_tag="KI385_02525"
     CDS             11331..11627
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="KI385_RS02520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02525"
                     /product="PqqD family peptide modification chaperone"
                     /protein_id="WP_238570595.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 4.8e-13,
                     bitscore: 47.9, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-06, bitscore: 27.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWRLRESTHPVLTDEGGALLDERTGRWTHLTPTASAAVMLLLAGA
                     TEEEAAGQYATRYGISFEQAAADVRTVAAALTAQGLAATEPARRGRSWCRWWR"
     aSDomain        11337..11579
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KI385_RS02520_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.50E-15"
                     /identifier="RREFam002.1"
                     /label="KI385_RS02520"
                     /locus_tag="KI385_RS02520"
                     /protein_end="83"
                     /protein_start="2"
                     /score="47.9"
                     /tool="antismash"
                     /translation="RLRESTHPVLTDEGGALLDERTGRWTHLTPTASAAVMLLLAGATE
                     EEAAGQYATRYGISFEQAAADVRTVAAALTAQGLAA"
     gene            11624..12046
                     /locus_tag="KI385_RS02525"
                     /old_locus_tag="KI385_02530"
     CDS             11624..12046
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="KI385_RS02525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02530"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_238570596.1"
                     /sec_met_domain="PF13471 (E-value: 4.3e-13, bitscore: 48.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSMEAYATVRTGTFLERCAAAAGLALALVLLRLPFRHTTRAVRF
                     AWRAGCRPLTVARAEALVEAVRHTARLWPGRAACMETSLGAVLAAALLGGRLHWCLGVR
                     FSPPPTEYHAWAELPEDGPVGEYTEAGWHHHTALTI"
     gene            12133..13158
                     /locus_tag="KI385_RS02530"
                     /old_locus_tag="KI385_02535"
     CDS             12133..13158
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013315.4"
                     /locus_tag="KI385_RS02530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02535"
                     /product="protein-L-isoaspartate(D-aspartate)
                     O-methyltransferase"
                     /protein_id="WP_238570597.1"
                     /sec_met_domain="PCMT (E-value: 6.4e-22, bitscore: 77.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAVALAAEQVPERYYTHHEGRGPTPHRSNPVVIHRELATLDLRQ
                     HMRVAEYGTGSGYSTELIARLVGPTGEVTSLDIDAYLTRWASLIHHERGLDNVRCYTAD
                     GTAGFLERAPYDRVVAWCTPPLLPKAWTDQVADDGLIVAPLPIADVPNMTVVAKVRVRV
                     GEPVVKAVFTGGYIEATASPKGDLDLPGRWVDWENRVPDPSWISLAWRAQDDRLHTGAR
                     TALDRLLNAEHTEPYEGGDVDWPSWRTFAAALGNPQLAMAGLRPDLWAIGHSTTKTAAV
                     IQQDGTILADSPNSPSLSALREWLTSWENAGRPAPETYTPTLVPADDGQGPAGWHLQLS
                     R"
     gene            13427..13783
                     /locus_tag="KI385_RS02535"
                     /old_locus_tag="KI385_02540"
     CDS             13427..13783
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003960716.1"
                     /locus_tag="KI385_RS02535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02540"
                     /product="ASCH domain-containing protein"
                     /protein_id="WP_238570598.1"
                     /transl_table=11
                     /translation="MTTPPPPAEHTLNIRKPYFDLIATGSKTIEIRVGYAKIRKMAAGD
                     SLRFSSGDHSLLTRITDLSEYTSFEEMLTAEDNTAIGEPGMTRDQLLATCRDIYPPEKE
                     ALGVFAIHLRLPRT"
     gene            complement(13981..14925)
                     /locus_tag="KI385_RS02540"
                     /old_locus_tag="KI385_02545"
     CDS             complement(13981..14925)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569224.1"
                     /locus_tag="KI385_RS02540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02545"
                     /product="phosphotransferase"
                     /protein_id="WP_238570599.1"
                     /sec_met_domain="APH (E-value: 2.2e-10, bitscore: 39.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTAHWHFVKKRTADPAGGAVYVSDDGTLYRRTGGEALAAEAAYQ
                     RQLAELGYPVPRVLDDGTTADGRVFVVEESLGERSLHDMALEGLDGTRMLSDTVVDLAA
                     EVGSRLLWAQAAHAVTADLQALQSWVREAGWTDNVFAENPDLDTLRVRAALGRAVAQLA
                     GVPMVRGHLDYGLPNVLPVGVIDWQHHGLVPVGYDVALALEIVPFMGGTKGYLATSEQR
                     RRYLEELSEVARATTGQALSQHLGPYLLVKALFFLALMKPTDPARTDKHLKWHYRRHQF
                     VEVLEQYECTGAVDTARLPTRDVFAARHGAGHP"
     gene            complement(15493..15729)
                     /locus_tag="KI385_RS02545"
                     /old_locus_tag="KI385_02550"
     CDS             complement(15493..15729)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02550"
                     /product="hypothetical protein"
                     /protein_id="WP_238570600.1"
                     /transl_table=11
                     /translation="MSGAHASPRQDSIGVAVWRPIMLLATLGVGAPAAVVSGAVDAHSA
                     PSRATVPDTAAQAAAVGHTAPTRPCRCGTSTCR"
     gene            complement(15726..15926)
                     /locus_tag="KI385_RS02550"
                     /old_locus_tag="KI385_02555"
     CDS             complement(15726..15926)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089788.1"
                     /locus_tag="KI385_RS02550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02555"
                     /product="hypothetical protein"
                     /protein_id="WP_238570601.1"
                     /transl_table=11
                     /translation="MSADVGDEVEYAADRRAVVTDIRAGIYYLRCPGRAEWPVEDPDTL
                     TVTRTRAERIKADGPCHGLFW"
     gene            complement(15923..16204)
                     /locus_tag="KI385_RS02555"
                     /old_locus_tag="KI385_02560"
     CDS             complement(15923..16204)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02560"
                     /product="hypothetical protein"
                     /protein_id="WP_238570602.1"
                     /transl_table=11
                     /translation="MTMATDHQRADHAAATPFRIGERVTGMTYVPRENRPFEQPRPFEG
                     DVVQVGSGYAGVDADDAYVWARLDDGTECQALIVDTKPSTTETPEAGR"
     misc_feature    complement(16201..16221)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.66"
                     /tool="antismash"
     gene            16390..17646
                     /locus_tag="KI385_RS02560"
                     /old_locus_tag="KI385_02565"
     CDS             16390..17646
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014386351.1"
                     /locus_tag="KI385_RS02560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02565"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_238570603.1"
                     /transl_table=11
                     /translation="MNWQTGPIRDASRAGDYGRVIALAREEQRMTQSQLGQACGLSQSA
                     VSHLEKRGAGAYSTDILAAASAHLGFPPALVGLVDGRGRRRGPVNGSDSSDVDRRQFLG
                     GAAAVAATPVLDALPDPADTTTGQAAALRLSTTAYRRLDGTTPSRDLSDTVESHLRLIQ
                     SITRNATDDAERRRLAAVGSEAASLAGWLAWDRGDDGSARSWYGSAIKAAGSAGDPLLA
                     AYQLGTLAQFEADNGNATEALNLTRRARRSLGAQRPSVADAWLSSVEALAHAAGGDRRS
                     ADRALTASRTAAETLPAEVPPWPWVFRFDPVKAAACRVTCGARLGLPEWVLGDGTEALA
                     TGHAKQRALLVLDIAAGHLAGGQIEAAFALAGRALETGLQYRSGRIVERVRAVRRSLTS
                     GAPPRVVRDLDERLHGVCL"
     misc_feature    16492..16494
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17664..18137
                     /locus_tag="KI385_RS02565"
                     /old_locus_tag="KI385_02570"
     CDS             17664..18137
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014386350.1"
                     /locus_tag="KI385_RS02565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02570"
                     /product="hypothetical protein"
                     /protein_id="WP_238570604.1"
                     /transl_table=11
                     /translation="MRVGITGHRGLDQDVERQVRGLLDDAVREWEPAELVVSCIADGPD
                     SWFAEAVLKHGGRLEVVVPAREYRSGLPSWHHPTYDALLRQAVDVHETGLTTSDSAAHM
                     AGSEILVGLVDQLLAVWDGKPARSHGGTADVVAYAERTGTPVQVVWPQGATRG"
     gene            complement(<18282..18407)
                     /locus_tag="KI385_RS44140"
                     /pseudo=""
     CDS             complement(<18282..18407)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020554296.1"
                     /locus_tag="KI385_RS44140"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="pyridoxamine 5-phosphate oxidase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIEVLNRPIGQELLARDVTRLAYVAKDGTPRNVPIAFTWNGS"
     gene            complement(18426..18866)
                     /locus_tag="KI385_RS02570"
                     /old_locus_tag="KI385_02575"
     CDS             complement(18426..18866)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182441.1"
                     /locus_tag="KI385_RS02570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02575"
                     /product="VOC family protein"
                     /protein_id="WP_238570605.1"
                     /transl_table=11
                     /translation="MAIQRMDNVGIVVEDMDAAVAFFVELGMELEGRAEVEGLVADQCT
                     GLDGVRCDIAMVRTPDGHSRLELAKYRSPAVISAGPRNRPYNILGTHRVMFAVDDIEDT
                     VARLRPHGAELVGEFARFEDSYLLCYIRGPEGIIVGLAEQLR"
     gene            complement(18995..19438)
                     /locus_tag="KI385_RS02575"
                     /old_locus_tag="KI385_02580"
     CDS             complement(18995..19438)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02580"
                     /product="hypothetical protein"
                     /protein_id="WP_238570606.1"
                     /transl_table=11
                     /translation="MAPESGGDGDFTGIDLKGMLVAEGVSLDRVGPDSCPLRRATHDSY
                     CGVRSTRAVRGLITSYLPVPRARGAAGGTRKAGAQSAEAGGKGAGTENNTPRGRRNAQA
                     RTLRIVEEALKSGDGTLRLIAFMGAATCAALTLGGGAWLAGLL"
     misc_feature    complement(19253..19255)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19479..19940
                     /locus_tag="KI385_RS02580"
                     /old_locus_tag="KI385_02585"
     CDS             19479..19940
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02585"
                     /product="hypothetical protein"
                     /protein_id="WP_238570607.1"
                     /transl_table=11
                     /translation="MSNTPSDSDKSDKKALASHLSTTLDPGDDEEFLVTIGAAAALLCA
                     FVYMGSMTYTFAHYRSWADPVAFVVSVVFALVALLSAVPLVMARGLGRSPVLPRAVMWG
                     TGLVLAGLQLTAAVLGNATFSMSAVIGITTALAVPCFGEIAGRGAHSAA"
     gene            19974..20186
                     /locus_tag="KI385_RS02585"
                     /old_locus_tag="KI385_02590"
     CDS             19974..20186
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018522429.1"
                     /locus_tag="KI385_RS02585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02590"
                     /product="hypothetical protein"
                     /protein_id="WP_238570608.1"
                     /transl_table=11
                     /translation="MRFFWLAALGVLAVVMAVFTPYVLRHESVWQSIGWLVMLVGTIGV
                     IAVLIRAELLLRSLDRRARSDLSSR"
     misc_feature    20316..20333
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            20340..21461
                     /locus_tag="KI385_RS02590"
                     /old_locus_tag="KI385_02595"
     CDS             20340..21461
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02595"
                     /product="hypothetical protein"
                     /protein_id="WP_238570609.1"
                     /transl_table=11
                     /translation="MTTPTAPAPPTTAPRPGYRDRLRARYATAAEERIDKARTAALELG
                     HTGPVPWEDLRAAYTRPSRTPWKSCRMLLGGALGAALMMTLVVGSAAMTLLSLDAEQKR
                     ETTAAAKKTQVAPLSVEQKKKADRALAKGAGKAAAVGFVVTLAFSSYRRMSDKRDGLLK
                     GYVKDGDQVVTEALDALPSLAALASAPAGRTRTEALTDVHEKVSELMTAVTNSADAAGG
                     LQAKYAADQRRLREHGQKVRTAFADKLSELVEDRERAARELGAMVLTVAARQAQAAYGA
                     LLDADALPAEPGPEVVEVKGLGGVFAIAGVAAAASLVIAPAAGAEGAGLLFIPLTVFTL
                     AAFLSAAFTRKLHQLGRVVALFGRSGPGAGGVL"
     misc_feature    20403..20405
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(21537..21917)
                     /locus_tag="KI385_RS02595"
                     /old_locus_tag="KI385_02600"
     CDS             complement(21537..21917)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538861.1"
                     /locus_tag="KI385_RS02595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02600"
                     /product="hypothetical protein"
                     /protein_id="WP_238570610.1"
                     /transl_table=11
                     /translation="MSDAMHIVLDDTAMTAAGQGNVLASRLIHRAHAEPGWYLYAPTCA
                     LVEADRARPGTAEHLAALPGITVLDLDLPAALAVAQQETWAAAHSQYAAQPTPDRPDGA
                     IVATTAPKRWDGEPVRVLDLNA"
     misc_feature    21986..22000
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 20.54"
                     /tool="antismash"
ORIGIN
        1 ggttgctcgt cgccgctggc tacggtccgg ctcgtgccgg tggagattct gactgacgag
       61 caggccgagg cgtacgggac gttcaccgcg gtgcccacgc gtccggagct ggagcggttc
      121 ttcttcctcg acgatggcga ccgcgatctg atcgcgcggc gtcgtacgga tgcgcaccgt
      181 ctgggtatgg cggtgcagat ctgcacggtc cgatacatcg gccggttcct gggcgaggat
      241 ccgctcgcgg tgccgtggga ggtcgtggag cacctcgccg ggcagctcgg catcgaggac
      301 tcctcgtgcg tgaagcggta ccccgagcgc aggtcgacgg tgtacgagca cgcggatgag
      361 atccaggagc ggttcaagta ccgggacttt accgaccgga agtggggccg ggagttccgg
      421 agcttcctgt acgggcgggc gtggacgcac gccgaggggc cggtggcgct gttcaaccac
      481 gcggtgacgt ggctgcgcaa gaaccggggg ctgctgcccg gggtctcggc gctggcccgc
      541 tacgggcagt tgagcaaggc gcagacgatc gagcgggcgc cgcaaccgcg gcgcaccgcg
      601 ctgctgacgg cggtggtgcg ccagctggag gcccaggcgg tcgacaaggc cagcagcccc
      661 tgccgggacc tgcgcccgct gcgcgacccg gatgcgcccg agctggacga ggacgacggg
      721 gccctggact gacctgggct ttcccaggct gcgcctgtgt catccgcggt cgctgacccg
      781 ctgcgcctcg ccttgatctt caacctgtgc cacacggtcg cgagccggtc gggtcagccc
      841 gctctgcggt gatggcccgg acgccttcgg gcggttacag cccagatgga tgcaggatgc
      901 gcccctggtc atcgaagccg tgtgttcgct ggaccgttct gtcgtgtgag aagcggttcg
      961 cggttcgctt cgggcgagcg tgagtttcgt cgacaaggtc agcgagacag tccagccggc
     1021 ccggacctcg tctcgtgagt cgtcgttgag caccgtgggc gtatcaggtg acggatgccc
     1081 agcgatggct gggcccgccg gtcagtcgat gccttcgacg atgcggaagt cgcgctcgaa
     1141 gccgtcgggg agggccacca gcgccttctg gtatgcctcg ctctcgtatg ccgcgaccgc
     1201 ctgttcaaag ccgtcgaact cgatcagaac gacgcgttcg gtgattccgg cctcgtgggc
     1261 gacgactcga ccgaaattgg acaggacgcg cccgccccca gcccggacag ccagacccgc
     1321 cagctcgttg tagtcagtca gcccctcagg gtcggaaatg gcggggtaga cactgaccca
     1381 gtagcccttg gccatggaaa cctcctgtgc tcggccggac acgtccgact tcgaattgac
     1441 actcagattg ctcgatcccg acgacggccc ggggcgaggt tctcaaatgc ctccgtcgag
     1501 gtcatgcctc gatccttgcc gttcgagccg gcctcggcca tggcagaaag gtcagcctcc
     1561 gatacattct cgccatgccc gtccaccatg ccgcccccgg tactcccggc gcccgcgacc
     1621 tagccggtcg caccgccgaa ccggatcgcg cgatgcgccc agaaccgcgg cccgccgccc
     1681 acaaggtggt cgtcctcgta gtcgacggga tctacccctt cgaactcggc atacctcaac
     1741 acgtcctggg ctccgccggt ggccgctacg aggtggtgac cgcgggcgtg gacgggaagc
     1801 ccgtgcgcac cgtctcggac ctgaccgtca cccccgggca cggccctgag gtgctggccg
     1861 aggcggacac cgtgatcatc cctgggtacg ccatcaccca ggccccggcc gccgccacgg
     1921 actcgaaggc cctggacgcg ctttccaggg tccggcccgg cacccgtctg gtgtcgatct
     1981 gcagcggtgc cttcctgctg gccggcaccg gtctcctcga tgggcgtcgg gccaccaccc
     2041 actgggcgct cagcgaccgc ttccgggaac tgttcccccg ggtcgagctc gacgccggcg
     2101 ttcttttcgt cgaccacggt gacgtgttga cctcagcggg ggcggccagc ggcttcgacg
     2161 tctgcctgca cctgctgcgc caggaccacg gcaccgaggt cgccaaccag gtcgcccgct
     2221 tctgcgtcat gccgccgtac cgggacggcg ggcaggcaca gtacatcgag cggccactgc
     2281 cgccgacggg cgcaaccggc accgggccga cccgcgactg ggcattgcag cggcttgaac
     2341 tgccgctgtc gctggacgaa ttggccgcgc acgcggcgat gagcacccgt accttcgccc
     2401 ggcgcttcaa ggaggagacc ggtctgagcc ccggccgctg gctgacctcg cagcggctgc
     2461 ggcgggcacg gcacctgctg gagtccagcg atctgccggt ggaacgcgtc gcccacgagg
     2521 tcggattcgc caccgccacc tcgctgcggc ggcacctcgc ggcggaggcc ggagtcgccc
     2581 cgtcggcgta ccgtcgcacc ttccgtgccc cggatccggc cgccggcgat gcgggctcca
     2641 ttccccacct agtcgtcgcc tcagtgtccg tcgcggacca ccgctaaccc gccgacccgg
     2701 gtcgtgatgc ccgccggccc gcgtcgggcc gaagcgagca cgctggccgg tcgaccgagg
     2761 gtgtcgccct gctccacctc gatcgcgacc gtctgcgccc ctgtcgtgtc gagcaggtgg
     2821 gcggccaggc agccggtgct gttggcgttg gcgacgtcct cgtcgacacc gatcgccggc
     2881 gcgaacatcc gcgccgcacc cggtcggtcg cccaccggcg gtacgtacac gaagcagccg
     2941 aggagcccgt accgctggca cgccgctgtc agcctgccga ggtgtgggcg gactcggagc
     3001 agcgccgacc ggtcgtggac cggtaccagc atgcgtggtg cgccgggcgc ggcgatccgt
     3061 ggcgcgtcgg tcggatgcgg atcgtccgcg gtgagcccga gcgcggcgac gatcgcggcg
     3121 cgctcgtccg gtgccgggtg acgcagcgcg acgaggccct ggtcgaacca cacctcgatg
     3181 ccggcgggac ggcggatcgc gacggtgtcg aacgtgcgcc cgccggtgtg ttggcggtcg
     3241 ttcagctcgc ccagcgcggt gcgggtcaac cgaacggcct gcgcggcaac ggtgccgtgg
     3301 ccgcagccgg acagttcggc ggtggcggtg aagaaccgga ccggccagcc accgtccggc
     3361 gtccgccctg ggcctaggaa cgccgcgtgc gaggtgctgg ccgcagcagc gaccgcacgc
     3421 cggtccgcgt ccgtcgccgc cgggtcgtcg tcggtgacgg ccgtggggct accgccccgg
     3481 ccgtcgcgcc gcacgcacgc atcaaccact gtgacaaccg gccaggacat cggcccacct
     3541 ttgacgctca acgaaccggc aaccgcgaac ggcgtccgcc gatagccatg cctggccgca
     3601 acggccgacc gaacgcgtcc cggagcgtac cagcctgccc caccgcggcc acggccagcg
     3661 tgccaagtca gggccggacg agcccatgac cggctcgccg gaagggcggc ggccccgtcg
     3721 ccctggtcgg cgccgaggag acatatcgac gatcgccagc gtcaatggcc tgctgagacg
     3781 agagcaacag gtggaccacg actcggccgg cagcatgcgc ggccttgcct cgaccatgcc
     3841 ggaacgaacc acagaaagat tcccgacaga gtctcccatt gtcggccccg gtgctgccct
     3901 cccccgtggg acagcaccgg gccgatctgg cttccgggct gtcctactcg tccccgccgt
     3961 cgtcgtcatc gtcgagctcg ggggcggccg ggtcgcgtag cgggcgcagg ccctggccgg
     4021 ggccgctggc cttgatgttg agcaggtagc ggcccaggaa gttgatgtgc cggtccttga
     4081 gcggggaggg ccgggcgacg tcttcgccct tgatgtcgtg tccttcggcg cggagctcag
     4141 cctgccagag caggaagccg gacaggcggg gctcgccgga cgtgcggatg agcaagtcca
     4201 agttggggag ccctgcggtg gccagatggt gctcgatggc cggcgccggc ggcccgtgcg
     4261 ggcaactcgc tacgccttgg ggcgggctgc gagataggag gcccagctgt cgttggcctg
     4321 gtcggaccat ctgccgacgg tggcggggtg gaggccgagc aggtcggcca cgacgatcgg
     4381 gggaaggctg gtcaccgctt cgatcatggc ggtgttgcgt gcggcacgga ccggcagtcc
     4441 cttttctcca aggagcttcg cgagtgtccc gccatcgatg gggcttccgg gaaccgttcc
     4501 gggcagcaga tagcggtctg aggcgccgag ttcgtggttg aggctgttgg tggtgctgcg
     4561 gtggatgatc tggtcttcga tgaggcgcgc gagcttgggt ggcagcagga cggggtggcg
     4621 ttcgaaggtc aggtaggcgg tgccctgtcc ctcgcggtgg aatcggctgg tggtcagttc
     4681 gatgatgcgg ctgacgggaa gtgcgtagag gcagatcagg gctcccgcga tgcgcagctc
     4741 ccgttgcagt gtttcgtcgt tgaggcagcg gcgaagctgc tgctcatatg cggtctctgt
     4801 caggaagtgt gaagcgctgc tgcgtggccg ggacgggagg gtgagcgggc cggtcaggtg
     4861 ccgtgctgtg gcccagcgga tgaacgcatg cagggtgtcg tacctggcgg gacgggttgc
     4921 gagccagcgg tcgaggtgtt cttgggccaa ggacgacagg tcgaggccct cgtcatcgag
     4981 ccagctgagg aaatcgaggg cggcctggac ttggctgcgg tcacgtcgtg ccgcgctgcc
     5041 ggagtaccgg tcgtgggcgg cactgcggcg tgcgtggcgg agcaatcccc actccgcgaa
     5101 gggccgaacg acctgtcgat ggggtggcgg cgcgtggccc agtgccttgt ccagccagag
     5161 gttcatctgg gccagccgct cctggcgcgg gggcagcact ccggtggtga ccaggaccgc
     5221 gcggacgtgg cgcgtgaccc tggtctgagg tagggcgtcg agtacgtcgt gggtgaggtc
     5281 ggaacgatgc tctgccagct ctgccagctc ggccagcagg gcggcggatc ggcttgtact
     5341 gagccagtca agcacggtgt aggggttggg cgtcagcgct tcggccaggg gggcgagttg
     5401 ggagggcacg gacccatgcc cagtgctgag acagtcttcg acgcgctccg tgagggtgca
     5461 gcgagggcac aggccacccg tcaggagatc tccgggggta tcgcagccgg aacatcctgt
     5521 gtgcgggtcg tcgcggccgc agcaggaagc gcacaggccc tcgccttctg gtgcccggcc
     5581 gatcatgatg cggacctgcc cggctcgatg gccgaggcgc tgaccgaggg cacctcgctg
     5641 ccgtccgacc agcccggccc cggacacctg gtgctcaccg acgacgagat cgccacctac
     5701 cgcgcccgca tcgcccacct gaccgccgtc agccgctgac caagcctgcg aagcgtctcg
     5761 tgcaggacag cgacgagggc gccccggcga aggccggggc gccaccgatc acatcggttc
     5821 aggcgaaggc cagttcgcgg aaggtgttgc ggacgtccgt caggggctgg cggtcgcggg
     5881 tgtagtagag cttgttggtc agcagtaccg cccagcggtc ggtggcgggt gagatccaca
     5941 tgccggtgcc ggtgaagccg tagtgcaccc atacgtcctg ttcatcgctc gtcccgggtg
     6001 cggggtgcca gaacaggccg cgtgcgggct ccaggccgtt ggtctgcacg gtcagggagt
     6061 aggaggtcca ctcgggcccg aaaccggctt cggtcggggc tgtggaggca tccagcatgt
     6121 accgcaggaa gccagtcagg tcgtcgagga cggtgaaggc gccggcgata ccgcacacgc
     6181 cgcccaggag gcgggcggag aagtcgtggg ctgtgccctt gagatgggtg tcggtctccg
     6241 ggtcgagttc ggtgggggca cagcgcgcgg cgatcggggc gggcagcggg ccgaagcggg
     6301 tggagtccat gcccagtggc cgccaggtcc gggcatcggc cacctggtca aggggctggc
     6361 cggcgaggta ttcggcgagg aagccgagga tgagggcggc ccggtcggtg tactcgacgg
     6421 cctcgccggg tggccggtgc agtccttcgt gcaggacgcc gcggcggatg tcgtcctcgc
     6481 gggtgccgta gaggctcttc agctgagccc gcagtgggac gccagcggtg tgggtcagca
     6541 actgccgtgc ggtgacctgc ccgagcgggc ggttttccac ttcgggccag aagctgccca
     6601 gcggctggtc gaggtcgagg acgctgtcct cccagagggc tccgatggag gaccagacag
     6661 cgaggatctt ggtgaggctt gcggcgtcga agacggtgtc tggccgcatc ggtgtctcgg
     6721 gctcgtccgg gtccaagacg ccggtggtgc cgcttgcttg gacaccggcg ctgtcgccca
     6781 cggcccagac ggcgccggga tagaccttgt cgcggacgcc ttcggccagg agcgcttcga
     6841 tgcggtcgat catggtctcc ctgttcgctg tggctgtccc gccgattcag cgtagtgacg
     6901 cgggcgggtt ggttgttggt gcggcgcggg ctcagtgcgt gagccggcgg ccgagggtgt
     6961 gcagggctcg ggcggtggct gagagcgggt agcgggcggc attggcatag ctggcctccc
     7021 gcagggcggg cagcagggcg gtggtggttc gcagccgctc aaggtgccgg gccaccgcgg
     7081 cgggctgggt gaagtcggtg gccactgcgg tggcgccgag agcatcacgc aggccgggga
     7141 cgggctggta gagcacgggc agtccgcatg cctgggcttc gagggcgacc aggggctacc
     7201 agccccgcat cccagccagg gccttcatgc tcgcccccgc cggccgccgc ccgatcctcc
     7261 ccgaccagtt cctccaaggg tgcgcaccac tgtctcgtcc cggacagttg aggccgatcc
     7321 catccgagtg tccgcgcggt ccgcaatcat gaacgaggac agccgatctc caggagggga
     7381 ctatggcgag catctgggtt ctcacccagc ccgctgacac gagcaagcag gaggcgatcc
     7441 tggccgatgt gatcaccggc gtcagaggca gcaagaccag tgtgtacgcc atcaggtccg
     7501 acacccggga cctggttccc ctcgttgaat ggtcgacatc gttcgataag cgcgacccgc
     7561 tgccggccgg gttctacatc tccttcctgc agaccctgga cgaggctcag cggaagaacg
     7621 ccgacctgaa ccggctgatc atggccaaat gggtcatcga ccagcaggaa tggcagtggt
     7681 tggtccagga catcgaagat cttgcccccc gcgagttcta gcgtctcgtg caggcagcga
     7741 cgggggcgcc ccggcgaagg ccggggcgct ggccgcatcc gggcctcgct cggccgggtc
     7801 caggaccccc gccccagtgc ttcacgagcg ggaggcgagg cgctggctga gttcttgggt
     7861 tgcggcgctg tgggggatgt tgggcaggcg ggcggcgata ttgctcaggc cgtcgttgat
     7921 gcggacggac tgtacgccgt ccgcgcagtc gaggaagtcg ttccaggtgg ccagggcctg
     7981 ggcggtgttg ccgcgcttga gctggacgtg gccgaggtcg gcgagcacga tcgcccgggt
     8041 tctcttgcgg tcgaggccgt ggatgtcgag ggccaggtgc aggtgttcct ccgccgcggc
     8101 gaggtcgccc atcgtggcgt ggatcatgcc ggactcgtgc gcccaccggc cgtggctgta
     8161 gtggctggcc cacgactggc cgggcatggc cggggcgttc tcgatcgcgg tctgtgcgaa
     8221 ggtcaacagc ttggcggcgg tggtgcggtc gccgtcggcg gcggccgcgc gggcgtaggt
     8281 gttgcggtag taggccagtg ctttggggtt gttcagtttg cggccgcgct gctcgcaggc
     8341 ctcggcgagc cggacggcgg tggggatgtg gccgaggtcg atggcctggt cggcgaggcc
     8401 acgcagggcg gtggcagcga gttcgttctc gccggcctcg gcggcgaggc ggaagctgtg
     8461 caggttgtac ttctggctca gcccctggtt gccctcatcc cgggccatcc agccgatcag
     8521 gtggaccagc tcgctggtgg cggcgaacag ctcgcgcccg accgtgtcgg tgtagcggcc
     8581 gtccagccag cgtttgacgt cgacggtcag gtagcgcacc gccaggtggc gggcgtggcc
     8641 gccgccgagc tcggaggcgg cgtctccgag ggtggtggtc atggtgcgga ccgccgccac
     8701 ctcgcccctt ccgaccgcga cggggcctgg ccggttcgag tggcgggtca cggcctcggc
     8761 gtcaggtagg tcgagtgcgg ccaggccgac ggcggcggat gcggtgagga actgccgtcg
     8821 gtccacgtcg ctgcctccca agcgcatgac tgacgtcacg gtatcggcga actgggcttc
     8881 atggtccccg gacagatcaa ggtgcagaac ctgttcgatg aagggcagcc actccttggg
     8941 ccctcgccgt ccggtctccc accggtagac ctgctgccgg tcgagaaatc ctggctttcc
     9001 ccagcgcgcc accgaaagct cgtcagcgag cttctcctgg ctgcatctgg gacgccgtgc
     9061 ttcacgtgcc gcgcggatgc gctccccgag ggtcatgtcc ggccgatcgt cggtcctggt
     9121 tcacaactgg cctacagctg gcagacattg tggcagctgt ccacgctacg cgtccgggcg
     9181 ttgactcatc gtcatagccc gtccggacag aggccgggca gcgagtgaag ggacgcatcc
     9241 catggagcac accatcaccc ccgtctatca ggcgcccgtg gtgctggacg ccggcgacgt
     9301 cgtcgcggtg acgctgggca ccaacaactt cgacaccgcc gacgacaccc agtacaagaa
     9361 cgcctgagtc cgcggactgc cggggccggc aggagatgag cgccacggtc ggccccggcg
     9421 ccagaaggcg ccgggcctgt tcgttctcgt gctggggcac gggaaggggc ggcccggcgc
     9481 cttcgccttt cgacgcacaa cggagaaggg aagaggcacc gatgaggtgg agcgcgggat
     9541 ggtacggcgg caccgggcac gaccggctgc ctgccggggg ccgggcgatg cccggcctgg
     9601 acagaacatg gacggtcggg tggccggggg cccgggtccg cgccgtgggc gagggccacg
     9661 ttgcgcttgc ggtggtcggc gaatgcggcg ccgacaacgc ccagttggag cgggcgctgc
     9721 cggtggtgcg ggcgaaagga tggcggacgc tgacccgctg gcccggctcc tacctgacga
     9781 tcgcccgcag cggcgaggtg ctggcagtga tcggtgacct ggccggtcag cacccggtgt
     9841 actggcggct gacggcgctg gaacctggtg gtcgacctcc gccgccgctc tggcggcgct
     9901 ggacggggct cctgccgatc cgaccgcgct ggccgctcac ctcgccctgg cccagccgga
     9961 cgtcctgggg cagtggagcc tgttccgctc ggtgagccgg gtgccgactg ggcacctgct
    10021 gctgatcggc ccggagggcg cgggcgccct ccggtacgag ccggccgagt acgggccggt
    10081 ggacctgcgc gatgccgcgc cgacggtgcg cgccgcatta tccgaagccg tcggctttcg
    10141 atgtgacggc cggcctgtca gcgcggatct ggcggggctg gactccacca cgctggcttg
    10201 cctggccgca cagcgtggcg cggttgccgc ggtgacgttc gccgacgcac gcctacggga
    10261 tgacgacctg gcgtatgcgg tccgcaccgc ggccgcggtg cccaacctcg ctcaccacac
    10321 agtgcccggg agcccggaga ccgtctacta cgccggcctt gaggacctct cggcgctgcc
    10381 ggtcaccgac gccccgaacg cctacgtggt gaccgcctcc atcaagcggg ccgtcctgga
    10441 tcccgtcgcc ggacgccaca ccgcaggcgt gcacctgaca ggggcggccg gggacgcggt
    10501 actgtccgcg ccctcgtcct acctggccga tcttctgcgc gagcgacagc accaccgtgc
    10561 ctggcagcac gcacaggccc acgcccggct ccggcacacc tccgccctgt ccctgctgcg
    10621 gcgggcccga ccggcagccc gcacggatct ggccggagcc ttgcgcacga cagctgccga
    10681 actgcggcgc cctccgcgcc cgtgggtgcc ccaggcagaa cggccggtgt cctgggcgcc
    10741 gctgctggcc accgccgact ggatgagcct cgacctacgt gaccggctcg ccagcgctct
    10801 cgacgtcgcc gccgaactgg ccgatggccc cgcccggctg gcggcatggg ccagccgcca
    10861 agacctcgca cgggtcgggg cggacaccac cgggtggcgt gagatcgcgc tcaccgggta
    10921 cggcatcgag gtcgccgccc cgttcctgga caacgaggtc atccgcgcct gcctggccgt
    10981 gcccgccgac cagcgcggca ccccgggccg ctacaagccc ctgctgggcg aggccttcgc
    11041 ccctgccggc gtactgccgc ccttcgccct ggcccggtcg acgaagggcg gcttcaacgc
    11101 tctcgcgtat gcgggcctgc gcgaacacgc ctccgtactg cgggatttgc tcggcccgtc
    11161 ctctcggctg gcggccgccg gcctgatcac cgaggcaccg gtggacacga tgctccagcg
    11221 ggccgctgcc ggacagccca ccgcccaggg cgccctgcac ctcgcggtcg ccgccgaagt
    11281 ctggctgcgg cagctggaaa cggccccggc ctggtgggag gtggactccc gtgtggcgac
    11341 tgcgtgagag cacccatccg gtcctcaccg acgagggcgg cgccctcctg gacgagcgca
    11401 ccggacgctg gacgcatctg accccgaccg cgtccgccgc tgtgatgctc ctgctggcgg
    11461 gcgccaccga agaagaggcc gccgggcagt acgccacccg ctacggcatc agcttcgagc
    11521 aggccgccgc cgacgtccgt accgtcgccg ccgcgctcac cgcgcagggc ctcgcggcca
    11581 cggaacctgc gcgtcgcggt cgcagttggt gcaggtggtg gcgatgacaa gcatggaggc
    11641 gtacgccacc gtccgcaccg gcaccttcct cgaacgctgc gcggcggcag ccggcctcgc
    11701 cctggccctc gtgctgctgc ggctgccctt ccgccacacc acccgcgcgg tccgtttcgc
    11761 ctggcgggcc ggatgccgcc cgctgaccgt cgcgcgggcg gaggcgttgg tcgaggcggt
    11821 acggcacacc gcccggctgt ggccgggacg tgccgcctgc atggaaacct cgctcggcgc
    11881 ggtcctggcg gccgccctgc tgggcggccg tctgcactgg tgcctgggcg tgcggttctc
    11941 cccgccgccg actgagtacc acgcctgggc cgaactgccc gaagacggcc cggtgggcga
    12001 gtacaccgag gccggatggc accaccacac tgccctgacg atctgacctg tccgaaggtc
    12061 ccgggcgccg tgtccttcac ccgcccggag cagttgtcgc atacgcgtac ccaaccctcg
    12121 aaggagtgag ccgtgaacgc cgttgccctg gccgccgagc aggtccccga gcgctactac
    12181 acccaccacg aaggccgcgg cccgacgccg caccgctcga acccggtcgt catccaccgc
    12241 gaactggcca ccctggacct gcggcagcac atgcgggtcg ccgagtacgg cacgggctcc
    12301 ggctactcca ccgagctgat cgcccggctg gtgggcccca ccggcgaggt gaccagcctc
    12361 gacatcgacg cctacctgac gcgctgggcc agcctcatcc atcacgagcg gggcctggac
    12421 aacgtccgct gctacaccgc cgacggcacg gccggcttcc tcgagcgggc cccgtacgac
    12481 cgggtggtgg cctggtgcac cccgccgctg ctgccgaagg cctggacgga tcaggtcgcc
    12541 gacgacgggc tgatcgtcgc gccgctaccg atcgcggacg tgcccaacat gacggtggtc
    12601 gccaaggtcc gcgtccgcgt cggcgagccc gtggtaaagg cggtgttcac cggcggctac
    12661 atcgaggcaa ccgcctcccc caagggcgac ctcgatcttc ccggccgctg ggtggactgg
    12721 gagaaccgcg tccccgaccc ctcctggatc tccctcgcct ggcgggcaca ggacgaccgg
    12781 ctgcacaccg gcgcccgcac cgccctggac aggctcctga acgccgaaca caccgagccg
    12841 tacgagggtg gagacgtcga ctggcccagc tggcgcacct tcgccgccgc cctcggcaac
    12901 ccccagctcg cgatggccgg gctccgaccg gacctgtggg ccatcggcca ctccacaacc
    12961 aagacggccg ccgtcatcca gcaggacggc acgatcctcg ccgacagccc caactcccca
    13021 tcgctttccg ccctgcgaga gtggctcacg tcctgggaga acgccggccg cccggccccc
    13081 gagacctaca ccccaaccct cgtccccgca gacgacggcc agggcccggc cggctggcac
    13141 ctgcagctgt cccgctgaaa cccgagggcg gcgaaggacc agggcgatgg acgccgccgc
    13201 ctccatcaac ctgtacgaac aacgaccggc aaaggcccgc aacgcggccc gcaagggcct
    13261 ggactccgcg cgtcgtcggc tccgtcctgg gccgagccgg cgacctcacc tcgttcctca
    13321 cccgctgcta tccccgccag gccgccgtgg cgcgaacggc tcaccacggc gagcgccgcc
    13381 cgcccggccc tgcacgcacc cccgccccgg aggtgaggag agcgcgatga ccaccccgcc
    13441 accaccggcc gagcacacac tcaacatccg caagccctac ttcgacctga tcgccaccgg
    13501 gtccaagacc atcgagatcc gcgtcggcta cgccaagatc cgcaaaatgg ccgcaggcga
    13561 cagcctgcgg ttcagctccg gcgatcactc cctcctcacc cgcatcaccg acctcagcga
    13621 gtacacgtcc ttcgaggaga tgctcaccgc ggaggacaac accgccatcg gcgaacccgg
    13681 catgacccgc gaccagttgc tagccacctg ccgcgacatc tacccgcccg agaaggaagc
    13741 cctcggcgtc ttcgccatcc atctccgcct cccacgcaca tgagaccgca acgacgggct
    13801 cctggtaggc caggcatctt cgcggagccg aggtgacgcg atcgggggcc ctggcgcctc
    13861 cagtggtgag ccgtaggtaa gactggatga gctcggcggc cggttctgcg tccggccgat
    13921 gctgccgccg ccgggcacct ccttcttcga cccgccaacg cggtcgagca ggaacggcga
    13981 tcacggatgg ccagcgccgt gccgagcggc gaagacgtca cgggttggga ggcgggcggt
    14041 atcgactgct ccggtgcact catactgctc cagcacctcc acgaattggt gccggcgata
    14101 gtgccatttg aggtgcttgt cggtgcgcgc ggggtcggtg ggcttcatca gcgcgaggaa
    14161 gaacagcgcc ttgaccagaa ggtaagggcc cagatgctga ctgagggctt gcccggtggt
    14221 ggcgcgggcc acctcgctga gctcctccag gtaccggcgc cgctgctcgg aggtggccag
    14281 gtagcccttg gtgccgccca tgaacgggac gatctccagg gccagggcga cgtcgtagcc
    14341 gaccggcacc aggccgtggt gctgccagtc gatcacgccg accggcagga cgttgggcag
    14401 accgtagtcg agatgcccgc gcaccatcgg cacgccggcg agctgggcca ccgcccggcc
    14461 cagggccgcc cggacccgga gggtgtcgag gtcggggttc tcggcgaaga cgttgtccgt
    14521 ccacccggcc tcccgcaccc acgattgcag cgcctgcagg tcagcagtca ccgcgtgcgc
    14581 ggcctgggcc cacagcagtc ggctaccgac ctcggcggcc agatcgacca ccgtgtcgga
    14641 cagcatccgc gtaccgtcca agccctccag agccatgtcg tgcagcgacc gctcacccag
    14701 cgactcttcg acaacgaaga cgcggccgtc ggcggtggtg ccgtcgtcca ggacacgcgg
    14761 gaccgggtat ccgagctcgg cgagctgccg ctgataggcg gcctccgcgg cgagggcctc
    14821 cccgccggta cgccggtaga gggtgccgtc atcgctgacg tacaccgccc cgccggccgg
    14881 atcggcggtg cgcttcttca cgaagtgcca gtgagcggta tccatcaggt ttctccctcc
    14941 ggggctccgt tgcggaaccg ccgtccgtac ggtgagcgag ggcgtgggcc agcacgcggg
    15001 cgtccatgac ccaacgccgg cgcagctcgg cgagcacctc gtccgcggac caagcaccat
    15061 gttgtcgtcc agaccgagcg gaccgcggct gatgccgtgg gcgtgaggcg tgacaacagc
    15121 agccgtcgtg ggcgttctgc gcgatgttca ccaggtgcgc caatgctggc ctggaccgcg
    15181 tagaggtccg cccactccag gacgcgccgg ctgttggacg aggagctgcc gggtggctgg
    15241 gcgggtgcgg cgccgctgcg gccgtcgcgc tgcggggtcg gctcctgaag gtactgagcc
    15301 ggccgcccat gcacggtgtt cgccctcttc ctcggccgcc tgcgctcgac gcgatcgtga
    15361 ggccctgaaa gagcgtcggc ccgggacgtc cacgacgggg gcgtatacgt cccgggccgg
    15421 tagccctcca cccggccagt cttgcctggc ctgtaccggg cggtgggcct ggcccgccac
    15481 ggggcgggcg gtctagcggc aggtgcttgt cccacatcgg caggggcggg ttggggctgt
    15541 gtgcccgact gcggcggcct gcgccgcggt gtccggcacg gtggcgcggg acggggcgct
    15601 gtgggcgtcc accgcgccgc tgacgaccgc ggccggggca cccactccga gggtggcgag
    15661 cagcatgatg ggccgccaca ccgctacgcc gatggagtcc tgccgcgggc tggcgtgcgc
    15721 gccgctcacc agaacagtcc gtggcacggc ccgtcggcct tgatgcgttc ggcgcgcgtc
    15781 cgcgtcacgg tcagcgtgtc cgggtcctcc accggccact cggcccggcc cgggcaccgc
    15841 aggtagtaga tgccggcgcg gatgtcggtc accaccgccc gccggtcagc tgcgtattcc
    15901 acctcatcgc cgacgtccgc gctcaccggc cggcctccgg cgtctcggtg gtgctcggct
    15961 tggtgtcgac gatgagggcc tggcactcgg ttccgtcgtc cagccgggcc cagacatagg
    16021 catcgtcggc gtccacgccg gcgtagccgc tgccaacctg gacgacgtcg ccctcgaacg
    16081 ggcgcggctg ctcgaaaggc cggttttccc gggggacgta ggtcatgccg gttacgcgtt
    16141 cgccgatgcg gaagggcgtg gccgcggcgt ggtcggctcg ctggtggtct gtcgccatcg
    16201 tcatcgtcat cgcctcgata cggggatggg ccggcgcccg aggggcgtcg gtgcactgac
    16261 agacagtcaa cgaccagcta caggcgtggg accatcggtt acccggtatc cgcatacgga
    16321 tatgcgcacg gcgcatatgg atgccgggtg ctggtggtgg ggctcgtagc gtgggggtgt
    16381 gccgtggtca tgaactggca gacaggaccg atccgggacg cgtcccgggc cggggactac
    16441 ggcagggtga tcgcgctcgc acgcgaggaa cagcgcatga cccagagtca gttaggccag
    16501 gcgtgcggcc tgtcccagtc cgccgtctcc catctggaga agcgcggcgc cggggcctac
    16561 agcacggaca tcctggcagc ggcgtctgca catctgggat tcccgccggc cctggtggga
    16621 ctcgtagacg gacgcggacg acgccggggg ccggtgaacg gatcggactc ctccgacgtg
    16681 gaccgacgac aatttctggg tggggcggcc gcggtggccg cgacccccgt actcgacgca
    16741 ctccccgacc ccgcggacac caccaccggc caggccgccg ccctgcgcct gagcaccacc
    16801 gcctaccgcc ggctcgacgg cacgacaccg tcacgggacc tgtccgacac cgtggagtcc
    16861 cacctgcggc tgatccagtc catcacccgc aacgcgacgg acgacgccga gcggcggcgg
    16921 ctggcggccg tcggcagtga ggcggcgagt ctggccggat ggctggcctg ggacaggggc
    16981 gacgacggtt ccgcccgctc ctggtacggc tccgccatca aggccgccgg ctcggcgggt
    17041 gacccgctgc tggccgccta tcagctcggc accctcgccc agttcgaggc ggacaacggg
    17101 aacgccaccg aggccctcaa tctcacccgg cgggcccggc gctccctcgg cgcacagcgg
    17161 ccctcggtcg ccgatgcgtg gctgtcctcg gtcgaggccc tcgcgcacgc ggcgggcggc
    17221 gaccggcgca gcgccgaccg ggcactgacc gcgtcccgga cggcggccga gacgctgccg
    17281 gcggaagtac cgccgtggcc ctgggtcttc cggttcgatc cggtgaaggc ggcggcctgc
    17341 cgggtgacct gcggcgcgcg cctgggcctg ccggagtggg tgctggggga cggcaccgag
    17401 gcgctggcca ccggccacgc caagcagcgc gcccttctgg ttctcgacat cgcggccggt
    17461 cacctcgccg gtgggcagat cgaggcggcg ttcgcgctgg ccggacgggc gctggagacc
    17521 ggtctgcagt accgctccgg gcggatcgtc gagcgggtac gcgcagtacg gcggtcgctg
    17581 acctccggcg ccccgccccg ggtcgtgcgg gacctggacg agcgcctcca cggcgtctgc
    17641 ctgtgaacag aaagggcgat tcgatgcgtg tgggaatcac cggccaccgt gggctggacc
    17701 aggacgtaga gcggcaggtc cgcggcctcc tcgacgatgc ggtgcgcgag tgggagccgg
    17761 ccgagctggt cgtctcgtgc atcgcggacg gcccggacag ctggttcgcc gaggcggtgc
    17821 tgaagcacgg cggccgcctg gaggtcgtcg tccccgcgcg ggagtaccgc tcgggcctgc
    17881 cctcctggca ccacccgacc tacgacgcgc tgctccggca ggcggtcgac gtccacgaga
    17941 ctgggctgac gacgtcggac tccgccgcgc acatggcagg cagcgaaatc ctggtcggcc
    18001 tggtcgacca gctgctggcc gtgtgggacg ggaagcccgc gcggagccac gggggcaccg
    18061 ccgacgtcgt cgcctacgcc gagcgcaccg gcacccccgt gcaggtggtc tggccgcagg
    18121 gcgccacccg aggttgaccg ctcccgagcc ggaagcgtct cgcagtggcc tgtgctgcgc
    18181 accctggtca gccgacacat ccgcgaggtg tggaagcggc attccccgcg ctggccagcg
    18241 ggacgcccgc aggtgcgtga agttcggcgc actccatcgc cggacccgtt ccaggtgaag
    18301 gcgatcggta cgttgcgcgg ggttccgtcc ttggcgacgt atgccaggcg ggtcacgtca
    18361 cgggccagca gctcctggcc gatcgggcgg ttcagaacct cgatgatctc gttcggctgc
    18421 ccttctcagc gcagttgctc ggccagtccg acgatgatgc cctccgggcc gcggatgtag
    18481 cagagcagat agctgtcctc gaaccgggcg aactcgccga cgagttcggc gccgtgaggg
    18541 cgcaggcggg caacggtgtc ctcgatgtcg tcgacggcga acatgacgcg atgcgtgccc
    18601 agaatgttgt acggccggtt gcgcggcccg gcgctgatca ccgcggggct acggtacttc
    18661 gccagctcga gccggctgtg accgtccggg gtccggacca tcgcgatgtc acagcggacg
    18721 ccgtcgagtc cggtgcactg gtcggcgacg aggccctcga cctccgccct gccctccagc
    18781 tccatgccga gctccacgaa gaacgcgacg gcggcatcca tgtcctccac gacgatgccg
    18841 acgttgtcca tccgctgaat cgccatgctg gtttctcctt cttcctcgtg cggccggtgg
    18901 tggccgctga tgtccctggg acggagccgg tggcacgttc tcgacatccg cagaccgccg
    18961 aactccgaaa aatctggatc gcgccacagc accgctacag cagacccgcg agccaggcgc
    19021 caccaccgag ggtgagtgcg gcacaggtgg ccgctcccat gaaggcgatc agccgcagcg
    19081 tgccgtcccc gcttttcaac gcttcctcga cgattcgcag cgtgcgcgct tgagcattgc
    19141 gcctccccct tggagtgttg ttttcggtgc cggctccttt gccacccgcc tcggcggatt
    19201 gggcgccggc ttttctcgta ccgccggccg ctccgcgagc gcggggcacc ggtaagtagc
    19261 tggtgatcag cccacgtact gcccgtgtgc tccggacacc gcagtagctg tcgtgggtgg
    19321 ctcgtcgcag tgggcagcta tcaggcccta cacgatcgag cgatacgcct tcggccacca
    19381 gcatcccctt caggtcgata ccggtgaagt cgccatcgcc gccggattct ggggccatga
    19441 tgcggacgtg ccggagcggc ccagggagag gaatcgcatt gagtaacaca ccttccgaca
    19501 gcgacaagag cgacaagaag gccctggcgt cccacctcag cacaacgctg gatcctgggg
    19561 atgacgagga gttcctggtg acgatcggcg ctgccgccgc cctcctgtgt gccttcgtct
    19621 acatgggatc gatgacctac acctttgccc actaccggtc gtgggccgat cccgtggcct
    19681 tcgtcgtctc cgtcgtcttc gcgctggtgg cgttgctgtc cgctgtgccg ctggtcatgg
    19741 cccggggcct gggccggtct cctgttctgc ctcgggcggt catgtggggt acgggcctgg
    19801 tcctcgctgg cctgcagctg actgcagcag tcctgggcaa cgccaccttc tccatgtccg
    19861 ccgtcatcgg gatcaccacg gccctcgccg tgccgtgctt cggagagatc gcaggtcgcg
    19921 gagcacactc cgctgcctga gccccgccag tgcccgcccc tttggaggat gtgatgaggt
    19981 tcttctggct ggccgcactt ggtgtgctcg ccgtcgtcat ggcggtgttc acgccgtacg
    20041 tgctgcgcca cgaatccgtc tggcagtcga tcggctggtt ggtcatgctc gtcggcacga
    20101 tcggcgtgat cgccgtgctg atccgggctg agctacttct tcgctcgctt gaccggcgtg
    20161 ctcgcagcga tctctccagc cgctgaccga ttccccacac cacgcgccgc cgtgtgcgtt
    20221 cggacgtccg gttggtgtcc agcatcacgc accggccgtg ccgtgtactc ctggccggtg
    20281 caaccagccg ctctcatcct gatgtgttcc tcgagtaacc aggagagagg acaacggcct
    20341 tgaccacgcc caccgccccg gccccaccga ccaccgctcc gcggcccggc taccgagacc
    20401 ggttacgggc ccgctatgcc accgccgcag aggagcgcat cgataaggcg aggactgccg
    20461 ccctcgagct cgggcacacc ggtccggtgc cctgggaaga cctccgcgcc gcctacaccc
    20521 ggccgtctcg caccccgtgg aagtcatgcc ggatgctcct gggcggagcc ctcggcgcgg
    20581 ccctgatgat gacgctcgtg gtgggctctg ccgccatgac cttgctgtcc ctggacgccg
    20641 agcagaagag ggagaccacc gcggcagcca agaagacaca ggtagcaccg ctgtcggtcg
    20701 agcagaagaa gaaggccgac cgggccctgg caaagggggc gggaaaggcg gcggcggtgg
    20761 ggttcgtcgt gaccctcgcc ttttcctcct accgccgaat gtccgacaag cgggacgggc
    20821 tgctcaaggg atacgtcaag gacggcgacc aggtggtgac cgaagccctg gatgcgctcc
    20881 cttctctcgc cgctctcgcc tccgccccgg cgggccgtac gcggaccgaa gcgttgaccg
    20941 acgtgcacga gaaggtctcg gaactgatga ctgcggtgac gaacagcgcg gacgccgctg
    21001 gggggctgca ggccaagtac gcggctgacc aaaggcgtct gcgtgagcac ggacagaagg
    21061 tccgcaccgc gttcgccgac aagctcagcg aacttgtcga ggaccgggaa cgggctgccc
    21121 gtgagctcgg cgccatggtg ctcaccgtgg cggcccgtca ggctcaggcg gcgtacgggg
    21181 cgctcctcga tgcggatgct ctgcccgccg agccgggccc ggaggtagtg gaggtgaagg
    21241 ggcttggcgg ggtgttcgcg attgccggtg tcgcagctgc ggcctccctc gtcatcgccc
    21301 ccgcggccgg ggcggagggg gcaggactgc tgttcattcc cctcacagtg ttcactctgg
    21361 ccgccttcct ctcggcggcg ttcacgcgga agctccacca gctggggcgg gtggtcgccc
    21421 tgttcggccg cagcggcccc ggcgcaggag gggtccttta gtcgcgcggg gcagcagtcc
    21481 tgtagcgctg tgggcctcgc cggatccggc gaggcccaca gcgtcgggac aaagggtcag
    21541 gcgttgaggt ccaggacccg gaccggctcg ccgtcccagc gcttcggggc ggtggtggcg
    21601 acgatcgccc cgtcggggcg gtccggcgtg ggctgggccg cgtactggct gtgggctgcc
    21661 gcccatgtct cctgctgcgc cacggccagg gcggcgggca ggtccagatc caggacggtg
    21721 atgccgggca gggctgcgag gtgctcggcg gtaccgggcc gggcgcggtc ggcttcaacg
    21781 agcgcacacg tcggtgcgta caggtaccag ccgggttcgg cgtgggcgcg atggatgagg
    21841 cgggaggcga ggacgttgcc ctggccggcc gcggtcatcg cggtatcgtc caggacgatg
    21901 tgcatggcgt cgctcaccgg ccggtcacct gagccagacg ccggtcgagc tcactgtcca
    21961 ggtcctgctg ctgggccgcg gtgggggcat agccgttcca cttcttcaac gcggcgaggg
    22021 ccttctccgc gcgctcggcg cgctcg
//
